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Dissertations / Theses on the topic 'Protease'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wartchow, Charles Aaron. "Carbohydrate protease conjugates (CPC) : stabilized proteases for peptide synthesis /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487847309050511.

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2

De, Veer Simon J. "Development of novel protease inhibitors for epidermal kallikrein proteases." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/114508/1/Simon_de%20Veer_Thesis.pdf.

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Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks the escape of water and electrolytes from within. This structure exists in a perpetual state of repair and regeneration where the production of new cellular subunits (keratinocytes) at the base of the epidermis is offset by the gradual release of terminally differentiated corneocytes from the surface. It is increasingly clear that proteinases (h

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3

Josh, R. S. "Tailoring potent plant protease inhibitor against helicoverpa armigera proteases." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2014. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1969.

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4

Hamill, J. A. "Involvement of proteases and protease inhibitors in potato late blight." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426731.

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5

James, Karen Amanda Ellis. "Design, synthesis, and evaluation of novel cysteine protease inhibitors." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/30283.

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6

Lourbakos, Afrodite 1972. "Activation of human protease-activated receptors by proteases from a periodontal pathogen." Monash University, Dept. of Biochemistry and Molecular Biology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8876.

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7

Deo, Shivdeep. "DETECTION OF SECRETED PROTEASES AND A MEMBRANE PROTEASE IN PATHOGENIC ACANTHAMOEBA CULBERTSONI." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/256.

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Acanthamoeba culbertsoni (A. culbertsoni) is an amphizoic amoeba that is the causative agent of Granulomatous Amoebic Encephalitis (GAE), an often fatal central nervous system infection that is seen most frequently in severely immunocompromised patients and is characterized by hemorrhagic and necrotic lesions of the brain as well as varying degrees of granuloma formation. A.culbertsoni isolates have also been identified in a few cases of Amoebic Keratitis, a painful, sight-threatening corneal infection that disproportionately affects contact lens users irrespective of immune status. Common fea

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8

Groll, Michael. "Strukturelle und funktionelle Zusammenhänge und Unterschiede archaebakterieller und eukaryontischer 20S-Proteasome." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/13957.

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In eukaryotes protein degradation is performed by the ubiquitin-proteasome system. The 26S proteasome, a 2.5MDa large multimeric molecular machine, consists of more than 30 subunits and represents the core component of this proteolytic pathway. The complex is assembled from a proteolytically active 20S proteasome and two 19S regulator cap complexes. So far crystal structure, topology and enzymatic mechanism have only been elucidated for the 20S proteasome core particle (CP). CPs are assembled from four stacked rings of seven subunits each, following an alpha7beta7beta7alpha7-stochiometry. The

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9

Fishovitz, Jennifer. "A Chemical Approach to Distinguish ATP-dependent Proteases." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1291142553.

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10

Tiew, Kok-Chuan. "Dengue virus protease inhibitors." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/6117.

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Dengue virus (DENV) is a major health threat that affects 2.5 billion people, or 40% of the world’s population. However, there are no approved antiviral drugs or vaccines to treat Dengue infection. This thesis describes the design, synthesis and discovery of a new class of inhibitors of DENV NS3 protease. Structure-activity relationship studies have been carried out in order to delineate the structural elements responsible for the activity of this series of compounds. A lead compound suitable for further development has been identified.<br>Thesis (M.S.)--Wichita State University, College of Li

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11

Mariani, Victoria L. "Understanding HTLV-I protease." Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/30374.

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12

Donnelly, P. K. "Protease and human immunity." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371254.

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13

Ozdemir, Fatma Inci. "Purification And Characterization Of Cytoplasmic And Proteasome Associated Chymotrypsin-like Proteases From Thermoplasma Volcanium." Phd thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/3/1137629/index.pdf.

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ABSTRACT PURIFICATION AND CHARACTERIZATION OF CYTOPLASMIC AND PROTEASOME ASSOCIATED CHYMOTRYPSIN-LIKE PROTEASES FROM THERMOPLASMA VOLCANIUM &Ouml<br>zdemir, F.inci Ph.D., Department of Biology Supervisor: Prof. Dr. Semra Kocabiyik September, 147 pages In this study, two novel cytoplasmic serine proteases were isolated and characterized from thermophilic archaea Thermoplasma volcanium. The first protease was purified by ion exchange and affinity chromatographies and identified as a chymotrypsin-like serine protease mainly based on its substrate profile and inhibition pattern. The p

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14

Johansson, Per-Ola. "Design and synthesis of inhibitors that target the serine protease thrombin, the malarial aspartyl proteases plasmepsin I and II, and the hepatitis C virus NS3 serine protease /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/tek981s.pdf.

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15

Cameron, Angus. "Proteolytic enzymes from the hepatopancreas of the Kamchatkan King crab." Thesis, London South Bank University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264822.

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16

Dyllick-Brenzinger, Melanie. "The relationship between alpha-synuclein and the proteasome and its role in Parkinson's pathology." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16707.

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Morbus Parkinson (PD) ist eine Bewegungsstörung die durch intrazelluläre Einschlüsse, sogenannte Lewy Bodies, charakterisiert ist. Das synaptische Protein alpha-Synuclein (alpha-Syn) und Polyubiquitin sind Hauptkomponenten von Lewy Bodies. Das Ziel dieser Arbeit war es erstens herauszufinden ob alpha-Syn die proteolytische Aktivität des Proteasoms beeinflusst und zweitens die Auswirkungen der Proteasominhibition auf die Löslichkeit und Lokalisation von alpha-Syn zu prüfen. alpha-Syn inhibierte in vitro reversibel die 20S Proteasomenaktivität während in vivo alpha-Syn Überexpression weder in

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17

Mahajan, N. "Efficacy of diverse Capsicum annuum protease inhibitors against the adaptive plasticity of Helicoverpa armigera proteases." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2014. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1966.

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18

Fagundes, José Américo Gonçalves. "Avaliação da expressão do receptor tipo 2 ativado por protease (PAR2) e da atividade proteolítica presente no fluido crevicular de pacientes com periodontite crônica." Universidade de Taubaté, 2010. http://www.bdtd.unitau.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=429.

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O receptor tipo 2 ativado por protease (PAR2) é um receptor pro-inflamatório que pode ser ativado por tripsina, triptase, protease 3 produzida pelo neutrófilo e pela gingipaína (produzida por Porphyromonas gingivalis). Objetivo: o objetivo do presente estudo foi investigar a expressão do PAR2 na periodontite crônica em humanos, e avaliar se esta expressão está relacionada com a presença de atividade proteolítica no fluido crevicular. Metodologia: foram coletadas amostras de fluido crevicular gengival de indivíduos do grupo controle (sítios saudáveis com profundidade de sondagem ≤ 3mm, au

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19

Omnus, Deike J. "Regulation of a Transcription Factor Activating Protease." Licentiate thesis, Stockholms universitet, Avdelningen för cellbiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-57814.

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20

Mendieta, Martínez Laura. "Protease inhibitors as therapeutic agents." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/279388.

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Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study in four proteases: dipeptidyl peptidase IV (diabetes mellitus type 2), prolyl oligopeptidase (cognitive disorders) and cathepsins L and B (cancer).For the discovery of inhibitors, three strategies were selected: medicinal plant screening, high throughput screening and the characterization of a combinatorial chemistry library. Once accomplished the DPP IV recombinant expression optimization, t

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21

Dou, Dengfeng. "Mammalian and viral protease inhibitors." Diss., Wichita State University, 2010. http://hdl.handle.net/10057/3281.

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Chronic Obstructive Pulmonary Disease (COPD) is currently the fourth leading cause of death in the US. COPD is a multi-factorial disorder characterized by an oxidant/antioxidant imbalance, inflammation, a protease/antiprotease imbalance and apoptosis. This dissertation describes a general strategy for the design, synthesis and biochemical evaluation of dual function inhibitors which could potentially interrupt the above disorder, thereby enhancing the treatment of COPD. An example of this type inhibitor based on the 1,2,5-thiadiazolidin-3-one scaffold has been proven effective against both hum

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22

Allendorf, Sarah. "Site-1 protease in chrondrogenesis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66959.

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During mammalian skeletal development, endochondral ossification is preceded by the establishment of a cartilage template through a process termed chondrogenesis. Disruptions in chondrogenesis result in chondrodysplasia, a disorder of the appendicular skeleton which is characterized by disproportionately shortened limbs. A severe chondrodysplasia phenotype is observed when site-1 protease (S1P) is disrupted in both the zebrafish and the mouse, indicating that S1P is essential for normal skeletal development. To investigate the role of S1P during chondrogenesis, ATDC5 cells we

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23

Lee, Victor. "Synthesis of HIV protease inhibitors." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291434.

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24

Fox, M. T. "Characterisation of protease activated receptors." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599152.

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In order to characterise the thrombin receptor three mouse monoclonal antibodies were isolated by using a recombinant fusion protein incorporating the extracellular domain of the human thrombin receptor as an antigen. An affinity matrix prepared from one monoclonal antibody was used in the successful purification of the native receptor from human platelet membranes. Two of the monoclonal antibodies were capable of blocking thrombin-induced platelet aggregation, and this may lead to their use as possible platelet thrombin receptor antagonists. To characterise further the monoclonals, their epit

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25

Peng, Kah Whye. "Protease-activatable targeted retroviral vectors." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624668.

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26

Gordon, Nathaniel Charles. "Protease engineering for therapeutic applications." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648185.

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27

Barattini, Valeria. ""Protease-catalysed dynamic peptide libraries"." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517733.

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28

Udukala, Dinusha Nishani. "Protease assays for cancer diagnostics." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/17387.

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Doctor of Philosophy<br>Department of Chemistry<br>Stefan H. Bossmann<br>Numerous proteases are known to be necessary for cancer development and progression including Matrix Metalloproteinases (MMPs), Tissue Serine Proteases, and Cathepsins. The goal of this research is to develop a Fe/Fe₃O₄ nanoparticle-based system for clinical diagnostics, which has the potential to measure the activity of cancer-associated proteases in biospecimens. Our nanoparticle-based “light switches” for measuring protease activity, consist of fluorescent cyanine dyes which are directly attached to Fe/Fe₃O₄ nanopart

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29

Faria, Raquel Cristina Laranjeira. "Lichenicidin biosynthesis: LicP protease specificity." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7460.

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Mestrado em Microbiologia<br>The lantibiotics are ribosomally synthesized peptides produced by Gram-positive cells that have antibiotic or morphogenic activity. After translation, the lantibiotics undergo chemical changes that result in the formation of unusual amino acids (lanthionine and methylanthionine), as well as the establishment of chemical bonds that confer a polycyclic structure to the peptide chain. After modifications occur, the leader sequence of the prelantibiotic is removed to yield the active lantibiotic, a process that may involve a single proteolitical reaction or two

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30

Webster, Ailsa. "Characterisation of the adenovirus protease." Thesis, University of St Andrews, 1992. http://hdl.handle.net/10023/14300.

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The substrate specificity, classification, expression and control of the adenovirus encoded protease, the activity of which is required for the production of virions, is described. The use of synthetic peptides has shown that the protease cleaves sites of the form (M,L,I)XGG-X or (M,L,I)XGX-G and these consensus sequences have been used to identify potential cleavage sites in all the known substrates of the protease. Putative cleavage sites have also been found in a number of other adenovirus proteins including the major coat proteins, the hexon and the penton, that had not previously been con

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31

Song, Jing. "Functional characterization of extracellular protease inhibitors of phytophthora SPP and their targets tomato proteases." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1194563833.

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32

Ismail, Ihab. "Function and Regulation of Xylem Cysteine Protease 1 and Xylem Cysteine Protease 2 in Arabidopsis." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/11243.

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A functional water-conducting system, the tracheary elements of the xylem, is required to sustain plant growth and development. Tracheary element formation is dependent on many biological processes terminated by programmed cell death and cellular autolysis. The final two processes are probably dependent on the activity of hydrolytic enzymes such as XCP1 and XCP2 known to be expressed in tracheary elements during these final two processes. Thus, the transcriptional regulation of XCP1 and the function of XCP2 were investigated. Qualitative and quantitative assessments of GUS activity as directed

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33

Larocque, Angela M. "Interaction between protease inhibitors and proteases of European corn borer larvae Ostrinia nubilalis Hubner (Lepidoptera: Pyralidae)." Thesis, University of Ottawa (Canada), 1989. http://hdl.handle.net/10393/5698.

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34

Pol, Ewa. "Mechanism of interaction of the mammalian cysteine protease inhibitors, cystatin A and B, with target proteases /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2001. http://epsilon.slu.se/avh/2001/91-576-5927-3.pdf.

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35

Oetari, A. "Purification and characterisation of an extra cellular protease inhibitor and extracellular proteases of Stroptomyces lividans '66'." Thesis, Swansea University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638358.

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A proteinaceous protease inhibitor was identified and characterised from <I>Streptomyces livdans </I>'66' culture supernatants. The protein has a molecular weight of 11-kD. Comparison of the amino acid residues in a conserved region (two β-strands near the N-terminus involved in dimerization) indicated that this protein is related to other previously characterized <I>Streptomyces </I>proteinaceous protease inhibitors. The inhibitor obtained in this study has specificity for chymotrypsin-like serine proteases. A biological function of the inhibitor could be to control the activity of a native

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36

Conseil, Valérie. "Etude des proteolyses en culture et in vitro de la proteine p126 de plasmodium falciparum." Lille 2, 1996. http://www.theses.fr/1996LIL2T007.

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37

Lewinska, Marzena. "Verlängerung des N-Terminus von Proteinen mithilfe von IgA-Protease eine neue Methode zur posttranslationalen In-vitro-Modifikation von Proteinen /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967122260.

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38

Dunlevy, Fiona Kathleen Carol. "Protease-antiprotease imbalance in cystic fibrosis." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491992.

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Affects over 8000 patients In the UK. Persistent neutrophilic inflammation is associated with high levels of airway NE. DX-890 is a smallprotein inhibitor ofNE developed by Dyax, USA for use in CF. This project investigated the ex-vivo effects ofDX-890 on human sputum, neutrophils and epithelial cells, to help determine the potential ofDX-890 as a drug for CF. The Ki ofDX-890 was measured to be 11.12 pM. ICso values measured in pure NE and CF sol were similar, demonstrating that DX-890 retained activity in CF sol. Thickened dehydrated CF mucus may prevent access ofDX-890 to NE and reduce effic

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39

Pratt, Stephanie Ann. "Immunoglobulin A1 protease of Streptococcus pneumoniae." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/35410.

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The aim of this project was to examine the Streptococcal IgA1 proteases, with particular interest on the Streptococcus pneumoniae enzyme. IgA1 protease of S. pneumoniae was identified and characterised. A non-reducing polyacrylamide gel system was employed to screen clinical isolates for IgA1 protease activity. Of 187 isolates tested 18% were found to be IgA1 protease negative, there was no correlation with the site of isolation of the organism and its ability to produce the enzyme. Attempts were made to clone the pneumococcal IgA1 protease gene using the cosmid pEMBLcos4, the plasmid vector p

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40

Gariani, Talal. "Design of serine protease inhibitor peptides." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267244.

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41

Chong, Sannie Siaw Foong. "Anisotropic potential HIV-1 protease inhibitors." Thesis, University of Hull, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327289.

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42

Hattersley, Neil. "Characterisation of the SUMO protease SenP6." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521677.

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43

Eagling, Victoria Anne. "HIV protease inhibitors and drug disposition." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484290.

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44

Orr, D. C. "Studies on the rhinovirus 3C protease." Thesis, University of Hertfordshire, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382223.

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45

Nager, Andrew R. (Andrew Ross). "Mechanistic studies of a AAA+ protease." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/79189.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2013.<br>Cataloged from PDF version of thesis. "December 2012."<br>Includes bibliographical references.<br>AAA+ proteases are present in all branches of life and responsible for the energy-dependent degradation of most cytosolic proteins. Substrates for AAA+ proteases are unfolded and translocated into a compartmental peptidase. The requirement for protein unfolding raises several questions. How easily are proteins unfolded within the native environment of a cell? Are some proteins more difficult to unfold than

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46

Farbman, Mary E. "Mechanistic studies of the ClpAP protease/." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46048.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.<br>Vita.<br>Includes bibliographical references.<br>CIpA, a member of the Hspl00/Clp subset of the AAA+ superfamily, is an energy-dependent chaperone, disassembling and remodeling its protein substrates. CIpA also serves as the ATPase component of the ClpAP protease, where it is resonsible for binding specific substrates and unfolding and translocating them into its partner ClpP, the proteolytic component of the complex. We have used single molecule and traditional biochemical experiments to probe the mechanism o

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47

Thorne, Christopher Mark Cornelius. "Characterisation of ubiquitin specific protease 33." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548811.

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48

FALLER, BERNARD. "Interactions protease-inhibiteur. Influence de l'heparine." Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR13125.

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Nous avons evalue la capacite de l'eglin c a inhiber l'elastase pancreatique humaine, une enzyme soupconnee d'exacerber une affection grave du pancreas: la pancreatite aigue hemorragique. Nous avons mesure les constantes cinetiques d'association et de dissociation, parametres necessaires pour predire l'efficacite in vivo de cette molecule en vue d'une utilisation a des fins therapeutiques. La presence d'intermediaires reactionnels dans le processus d'inhibition est soupconnee lorsque la constante cinetique d'association est inferieure a la limite imposee par la diffusion. L'etude de l'interact

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49

Swedberg, Joakim Erik. "Rational design of serine protease inhibitors." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/48131/1/Joakim_Swedberg_Thesis.pdf.

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Proteases regulate a spectrum of diverse physiological processes, and dysregulation of proteolytic activity drives a plethora of pathological conditions. Understanding protease function is essential to appreciating many aspects of normal physiology and progression of disease. Consequently, development of potent and specific inhibitors of proteolytic enzymes is vital to provide tools for the dissection of protease function in biological systems and for the treatment of diseases linked to aberrant proteolytic activity. The studies in this thesis describe the rational design of potent inhibitors

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50

Patrnogic, Jelena. "Serine proteases and serine protease homologs : genetic analysis of their involvement in immune response activation in Drosophila." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ091/document.

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Lors de la réponse immunitaire de la drosophile, la voie Toll est activée lors d'un challenge immunitaire par des bactéries à Gram positif ou des champignons. Ce mécanisme est initié soit par la reconnaissance de motifs moléculaires associés aux pathogènes (PAMPs) qui activent la voie de reconnaissance, soit par des facteurs de virulence et des protéases produits par les agents pathogènes qui activent la voie des signaux de danger. Le travail que j'ai effectué a pour but de caractériser les différentes molécules impliquées dans ces cascades protéolytiques en amont de Toll. Cela permettra de re

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