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Dissertations / Theses on the topic 'Protein analogue'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Jimenez, Rosales Angelica. "Methyltransferases as bioorthogonal labelling tools for proteins." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/methyltransferases-as-bioorthogonal-labelling-tools-for-proteins(27231f93-7cdd-4c2d-9f31-0adc3f38b147).html.

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Development of enzymatic labelling methods has been driven by the importance of studying molecular structures and interactions to comprehend cellular processes. Methyltransferases (MTases), which regulate genetic expression by transferring a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to DNA, histones and various proteins, have been shown to accept SAM analogues with an alternative alkyl group on the sulfonium centre. These alkyl groups can be transferred to the substrate, and with a further reaction can be selectively functionalized. Thus, MTases together with SAM analogues h

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2

Allsebrook, Andrew M. "QPRTase : quinolinic acid analogue synthesis and non-enzymic decarboxylation of N-alkylquinolinic acids." Thesis, University of St Andrews, 1998. http://hdl.handle.net/10023/14376.

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Quinolinate phosphoribosyltransferase (QPRTase, E.C. 2.4.2.19) is considered to be a unique enzyme in that it is thought to catalyse two distinct chemical reactions. Both the transfer of a phosphoribosyl group from 5-phosphoribosyl-1- pyrophosphate onto the nitrogen of quinolinic acid and the subsequent decarboxylation of the intermediate to form nicotinic acid mononucleotide are thought to be catalysed by the QPRTase system. Analogues of quinolinic acid were designed as potential inhibitors of QPRTase. These contain acidic groups at the 2- and 3- positions but are unable to decarboxylate. How

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3

Anderson, Gordon James. "Molecular characterisation of the PRP8 protein on Saccharomyces cerevisiae and identification of an analogue in HeLa cells." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/11287.

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4

Schmiele, Marcio 1979. "Interações físicas e químicas entre isolado protéico de soja e glúten vital durante a extrusão termoplástica a alta e baixa umidade para a obtenção de análogo de carne = Physical and chemical interactions between isolated soy protein and vital gluten during thermoplastic extrusion at high and low moisture content to obtain meat analogue." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/255892.

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Orientador: Yoon Kil Chang<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-24T06:53:45Z (GMT). No. of bitstreams: 1 Schmiele_Marcio_D.pdf: 9722936 bytes, checksum: 95d9146270f349c5f3e7ad761ac0d266 (MD5) Previous issue date: 2014<br>Resumo: Os análogos de carne obtidos por extrusão termoplástica de proteínas vegetais são caracterizados pelo seu elevado teor proteico e estrutura semelhante às fibras da carne, envolvendo diversos tipos de ligações e/ou interações químicas entre as proteínas. O objetivo deste tr

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5

Frippiat, Steven. "Synthèses et fonctionnalisations de noyaux imidazolones : utilisations innovantes d'isonitriles et d'oxazolines." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMIR17.

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A ce jour, les dérivés d’imidazolones-4-arylidènes et dialkyles-(4,4’)-imidazolones font l’objet de nombreuses convoitises pour les scientifiques tant sur le domaine des matériaux via ses propriétés de fluorescence, que sur celui du médical, en particulier pour le traitement de maladies comme les cancers, l’hypertension ou la maladie d’Alzheimer. Les chimistes n’ont eu de cesses de présenter des procédés de synthèses plus originaux les uns que les autres pour l’obtention de ces imidazolones. Cependant, ces méthodes parfois anciennes, peuvent sembler être en décalage avec les demandes d’accéder

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6

Nemeth, Joseph. "Design and synthesis of chemical probes for the protein kinase B PH domain." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/572.

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7

GANDINI, ENRICO. "MOLECULAR DYNAMICS AND CHEMINFORMATICS METHODS TO EXPLORE THE CHEMICAL REALITY." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/888609.

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Part I: Antifreeze Peptides Organisms living in icy environments produce antifreeze proteins to control ice growth and recrystallization. It has been proposed that these molecules pin the surface of ice crystals, thus inducing the formation of a curved surface that arrests crystal growth. Such proteins are very appealing for many potential applications in food industry, material science and cryoconservation of organs and tissues. Unfortunately, their structural complexity has seriously hampered their practical use, while efficient and accessible synthetic analogues are highly desirable. In

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8

Milner, Steven John. "The oxidative folding of insulin-like growth factor-I analogues /." Title page, table of contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phm65945.pdf.

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9

DI, LUCENTE CRISTINA. "The phytotoxin fusicoccin: a regulator of multiple 14-3-3 targets." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/202271.

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L’identificazione della fusicoccina come metabolita responsabile degli effetti tossici di Phomopsis amygdali, dovuti alla sua capacità di attivare irreversibilmente l’H+-ATPasi di plasmalemma, ha dato impulso al chiarimento del meccanismo molecolare di azione della tossina. L’H+-ATPasi di plasmalemma è, ad oggi, l’unico bersaglio dell’azione della FC individuato. La mancata identificazione di siti di legame per la FC in batteri, lieviti, funghi e animali ha fatto ritenere che l’azione della tossina fosse quindi ristretta al regno vegetale. In questo lavoro è dimostrata la capacità della fitoto

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10

Carmona, Sylvie. "Un analogue de synthèse de la squalamine, NV669, comme nouvel inhibiteur de la protéine Tyrosine Phosphatase 1B (PTP1B) : étude de ses effets in vitro et in vivo sur la croissance des tumeurs pancréatiques et hépatiques." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0616.

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NV669 est un aminosterol dérivé de la squalamine qui a montré posséder des propriétés anti-cancéreuses. L'objectif de cette étude a été de rechercher les effets bénéfiques de NV669 sur des modèles de cancers humains pancréatiques et hépatiques et de comprendre les mécanismes cellulaires et moléculaires impliqués dans la diminution de la croissance tumorale par le traitement avec NV669. Les lignées cellulaires humaines pancréatiques (BxPC3 et MiaPaca-2) et hépatiques (HepG2 et Huh7) ont été traitées avec NV669 à différentes concentrations et à différents temps. Les résultats ont montré que NV66

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11

Mahajan, Shikha. "Protein Profiling of Adenine Nucleoside and Nucleotide Analogs Binding Proteins Using N6-Biotinylated-8-azidoadenosine Analogs as Affinity Based Protein Profiling Probes." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4139.

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Identification of differential expressions of proteins in proteomic profiles of biological samples shows great potential as a valuable technique for the early diagnosis of various diseases. An important challenge in modern protein profiling approaches is to reduce the complexity of the samples by limiting the number of proteins that need to be evaluated for distinction in the expression between normal and deceased cells. In this research, an affinity based approach for the enrichment of nucleotide and nucleoside binding proteins from a complex cell proteome has been developed. To achieve this

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12

Baldridge, Anthony Owen. "Synthesis, photophysics, and application of fluorescent protein chromophore analogs." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44744.

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The green fluorescent protein chromophore exhibits remarkably different properties upon removal from the protective beta-barrel. This work focuses on the synthesis of these chromophores as wells studying the photophysics as to why they readily deactivate. Following these initial discoveries, these chromophores can be applied to many different environments providing a fluorescence "turn-on" and thus proving to be applicable in a number of different environments and fields.

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13

Punyamoonwongsa, Patchara. "Synthetic analogues of protein-lipid complexes." Thesis, Aston University, 2007. http://publications.aston.ac.uk/9803/.

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Hypercoiling poly(styrene-alt-maleic anhydride) (PSMA) is known to undergo conformational transition in response to environmental stimuli. The association of PSMA with lipid 2-dilauryl-sn-glycero-3-phosphocholine (DLPC) produces polymer-lipid complex analogues to lipoprotein assemblies found in lung surfactant. These complexes represent a new bio-mimetic delivery vehicle with applications in the cosmetic and pharmaceutical industries. The primary aim of this study was to develop a better understanding of PSMA-DLPC association by using physical and spectroscopic techniques. Ternary phase diagra

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14

Rivière, Gwladys. "Étude par RMN de la créatine kinase musculaire et d’un nouveau domaine de liaison à l’ubiquitine dans la protéine STAM2." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10285/document.

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Au cours de cette thèse, nous avons étudié deux protéines par RMN : la créatine kinase musculaire (CK-MM) et le domaine UIM-SH3 de la protéine STAM2, seuls ou en interaction avec leurs partenaires. La CK-MM est une enzyme active sous forme dimérique. Elle appartient à la famille des guanidino-kinases et intervient dans le processus énergétique de la cellule. Le but de l’étude était d’élucider le mode de fonctionnement de la CK-MM. Pour cela, nous avons enregistré des expériences de relaxation R1, R2 et des expériences de perturbation de déplacement chimique sur la CK-MM libre et complexée avec

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15

Bae, Jae Hyun. "Studies on tryptophan analogues in proteins." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966131681.

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16

Kelly, Matthew. "Protein-related ripening studies in soy-cheese analogues." Thesis, Manchester Metropolitan University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267385.

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17

Jamieson, Craig. "Total synthesis, structure and function of protein analogues." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/12283.

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A previously unknown protein produced by an mRNA mutation has recently been identified in Alzheimer's patients. The protein, designated UbN, is composed of the first 75 residues of ubiquitin followed by an unrelated sequence of 20 residues. The synthesis of this 10.7kDa entity was carried out, as well as its purification which was based on a novel affinity support in conjunction with the tetrabenzofluoroene moiety. <i>In vitro</i> testing established how the protein could compromise the ubiquitin-dependent proteolytic system, hence exerting a toxic effect in Alzheimer's patients. The synthesis

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18

Reyes, Samuel Onofre J. "Expanding beta-turn analogs for mimicking protein-protein hot spots." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1748.

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19

Fischetti, Francesca. "Meat analogues: le nuove alternative ai prodotti carnei." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2022.

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Il presente elaborato affronta la tematica dei prodotti analoghi della carne, che già a partire da qualche anno si stanno affacciando sul mercato internazionale, con una domanda e offerta continuamente in espansione. Lo scopo dello studio è stato quello di delineare un quadro generale di tali prodotti da un punto di vista delle sue caratteristiche intrinseche e analizzandone le prospettive future di mercato, effettuando un’indagine sul consumatore, riguardante la percezione, la propensione all’acquisto e i motivi di tale scelta. La tesi si distingue in una prima sezione di tipo compilativo,

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20

Webster, Kerri Lesley. "Synthesis of nodularin analogues as potential protein phosphatases inhibitors." Thesis, University of St Andrews, 1998. http://hdl.handle.net/10023/14322.

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Reversible phosphorylation of proteins on serine, threonine and tyrosine residues, is now widely accepted to be the principal mechanism for the control of intracellular events in eukaryotic and prokaryotic cells. The nodularins are known to be potent inhibitors of serine/threonine protein phosphatases, PPlc and PP2Ac, with sub-nanomolar inhibition constants. They have been shown to form covalent adducts with the enzymes and are known to be potent hepatotoxins and liver promoters. Nodularin has the general structure: cyclo [(R)-eryphro-beta-methyl-iso-Asp-(S)-X-Adda-(R)-iso- Glu-N-methyldehydro

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21

Hardie, Sharon Shillinglaw. "Nucleotide analogues as reagents for site-specific protein-DNA crosslinking." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394811.

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22

Ravi, Swathi. "Recombinant elastin analogues as cell-adhesive matrices for vascular tissue engineering." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42728.

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Biomimetic materials that recapitulate the complex mechanical and biochemical cues in load-bearing tissues are of significant interest in regenerative medicine and tissue engineering applications. Several investigators have endeavored to not only emulate the mechanical properties of the vasculature, but to also mimic the biologic responsiveness of the blood vessel in creating vascular substitutes. Previous studies in our lab generated the elastin-like protein polymer LysB10, which was designed with the capability of physical and chemical crosslinks, and was shown to display a range of elastome

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23

Glidden, Michael D. II. "Single-chain insulin analogs as ultra-stable therapeutics and as models of protein (mis)folding: stability, structure, dynamics, and function of novel analogs." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522270994798884.

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24

Vasudevamurthy, Madhusudan. "Betaine analogues and related compounds for biomedical applications." Thesis, University of Canterbury. Chemical and Process Engineering, 2006. http://hdl.handle.net/10092/1096.

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Living cells accumulate compensatory solutes for protection against the harmful effects of extreme environmental conditions such as high salinity, temperature and desiccation. Even at high concentrations these solutes do not disrupt the normal cellular functions and at times counteract by stabilizing the cellular components. These properties of compensatory solutes have been exploited for stabilizing proteins and cells in vitro. Betaines are widespread natural compensatory solutes that have also been used in other applications such as therapeutic agents and polymerase chain reaction (PCR) enha

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25

Beeg, Marten. "Tetracycline and its Analogues as Drugs against Protein Aggregation and Amyloid Formation." Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522305.

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26

Perera, Aruna B. Kane Robert R. "Modification of fresh tissue surfaces ; synthesis of labeled L-dopa analogs; and synthesis of metoclopramide analogs /." Waco, Tex. : Baylor University, 2005. http://hdl.handle.net/2104/2998.

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27

Dunand, Christophe. "Perception d'un signal xyloglucane par des protéines membranaires et mise en évidence d'activité xyloglucane endotransglycosylane induite." Université Joseph Fourier (Grenoble ; 1971-2015), 1997. http://www.theses.fr/1997GRE10111.

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Afin de relier l'activite biologique du motif actif des xyloglucanes a la reconnaissance par des proteines membranaires, nous avons adopte une approche biochimique de detection basee sur l'utilisation de tests immunoenzymatiques. Nous avons utilise le dimere -l-fuc (12), d-gal marque avec de la digoxigenine ou de la biotine et des proteines solubilisees provenant de fractions enrichies en plasmalemme isolees de protoplastes de rubus, pour modeliser les interactions ligand-recepteur. Les resultats obtenus ont montre qu'une proteine membranaire de 62 kda est capable de fixer le dimere fuc-gal et

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28

Carrico, Isaac Sheridan Dougherty Dennis A. "Protein engineering through in vivo incorporation of phenylalanine analogs /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-09082003-110526.

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29

Farnaes, Lauge Luster Lindgren. "Novel analogs and a protein target for the napyradiomycins." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3372521.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed October 13, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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30

Tang, Yi Tirrell David A. "Protein engineering using unnatural amino acids : incorporation of leucine analogs into recombinant protein in vivo /." Diss., Pasadena, Calif. : California Institute of Technology, 2002. http://resolver.caltech.edu/CaltechETD:etd-08152006-084149.

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31

Leroux, Florence. "Etude in vitro d'inhibiteurs de tyrosine kinases et de phosphodiesterases et d'un analogue du vasoactive intestinal peptide potentiellement actifs dans l'asthme." Lille 2, 1996. http://www.theses.fr/1996LIL2P253.

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32

Gorni, Anita. "Meat analogues e carne artificiale: le nuove alternative alle proteine animali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.

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Il crescente interesse verso temi di sostenibilità e la crescita esponenziale della popolazione mondiale hanno portato a rivalutare l'importanza di fonti proteiche vegetali che potessero sostituire validamente quelle animali. La materia prima più comune da cui vengono estratte le proteine vegetali è rappresentata dalla soia, a cui si aggiungono cereali (glutine), semi oleosi e funghi; esse possono esistere sottoforma di farine, concentrati ed isolati, disponibili anche in forma testurizzata. Nel tempo, le proteine vegetali sono diventate il principale ingrediente utilizzato nella formulazione

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33

Likhodi, Olga. "Differential hydration of protein analogs in D¦2 and H¦2O." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0017/MQ54177.pdf.

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34

Adavalli, Sharat Chandra. "Extrusion and physicochemical properties of soy-whey protein meat analog." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6272.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on January 16, 2008) Includes bibliographical references.

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35

Jaquillard, Lucie. "Spectrométrie de masse supramoléculaire : caractérisation de l'intéraction non-covalente entre PEBP1/RKIP humaine et des analogues de nucléotides." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00923153.

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L'étude des interactions non-covalentes et des relations structure-fonction est à la base de la compréhension des systèmes biologiques. La MS supramoléculaire est une technique de choix pour l'étude des interactions protéine/protéine ou protéine/ligand. Dans le cadre d'études qualitatives ou quantitatives, pour chaque système étudié, les conditions expérimentales et les paramètres instrumentaux ont été optimisés pour conserver le complexe en phase gazeuse (1). L'objectif principal de ce travail est de caractériser le site nucléotidique de hPEBP1 et de contribuer à la découverte de molécules an

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36

Pichelin-Poitevin, Dominique. "Marquage differentiel de proteines membranaires par des inhibiteurs de thiols en presence de saccharose et de divers analogues." Poitiers, 1987. http://www.theses.fr/1987POIT2260.

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37

Beatty, Kimberly Elizabeth Grubbs Robert H. Tirrell David A. "Imaging the proteome : metabolic tagging of newly synthesized proteins with reactive methionine analogues /." Diss., Pasadena, Calif. : California Institute of Technology, 2008. http://resolver.caltech.edu/CaltechETD:etd-03052008-105142.

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38

Ji, Sifan. "Analogues polypeptides intelligents de la protéine fluorescente verte." Electronic Thesis or Diss., Bordeaux, 2025. http://www.theses.fr/2025BORD0010.

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La protéine fluorescente verte (GFP) s'est imposée comme une sonde fluorescente unique qui trouve des applications dans le domaine des sciences de la vie. La découverte et le développement de la GFP ont été dûment récompensés par le prix Nobel de chimie en 2008. La protéine se compose d'un chromophore central, intégré dans une chaîne polypeptidique hélicoïdale et encapsulé dans une cage protéique. Ces dernières années, des fluorophores synthétiques analogues au chromophore de la GFP ont été développés dans le but d'imiter les propriétés de fluorescence de la protéine et de ses dérivés. Ces flu

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Xu, Suxuan. "Fibrous soy protein meat analog from low moisture twin-screw extrusion." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6035.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 16, 2008) Includes bibliographical references.

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Davidson, Patricia Marie L. "Langmuir films and nanoparticle applications of a spider silk protein analog." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100794.

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A synthetic analog of a spider silk protein (M4) was studied. Langmuir films were made and an inflexion in the isotherm indicated conformational changes upon compression. Deposition onto solid substrates was most successful using a hydrophobic substrate and the Langmuir-Schaeffer method. AFM was used to image the surface, which was mesh like and did not show any indication of order.<br>Gold nanoparticles were produced in the presence of the protein and protein solutions were added to read made nanoparticles for the purpose of displacing the weak ligands present. CD measurements were performed

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Pandit, Bulbul. "Study of structure activity relationship of analogs derived from SU-5416 and thalidomide and mechanism of antiproliferative activity." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187127289.

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42

Qiu, Runan [Verfasser]. "Effects of nucleoside analogues on protein expression in cells of the SerW3 cell line / Runan Qiu." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1062536800/34.

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Frigerio, Mark. "Synthetic studies on novel bryostatin analogues and their interaction with the CRD2 of protein kinase C." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446848/.

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A fully stereocontrolled asymmetric synthesis of the Southern Hemisphere intermediate 426 for the bryostatin family of antitumour agents is described in this thesis. It details how the strategy evolved from (E)-1,4-hexadiene 450 including a Roush-Masamune coupling between 462 and 507, cyclisation to glycal 505, selective epoxidation and in-situ Fischer glycosidation to 503 and an aldol / dehydration sequence to establish the (E)-exocyclic olefin. We also document a rare example of slow bond rotation in the C(18)- C(19)-bond of 426 and provide an explanation of this phenomenon. In addition, the

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44

Lord, Andrew P. D. "IGF transfer from blood to tissue: comparison of IGF-I with analogs that bind poorly to binding proteins, using a vascular perfusion model : a thesis submitted to the University of Adelaide, South Australia, for the degree of Doctor of Philosophy /." Title page, abstract and table of contents, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phl866.pdf.

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45

MacDonell, Karen Loraine. "Relationship between cyclic AMP-dependent protein kinase activation and smooth muscle relaxation by cyclic AMP and analogs." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30098.

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It is generally held that adenosine 3',5'-cyclic monophosphate (cAMP) mediates smooth muscle relaxation by the activation of cAMP-dependent protein kinase (PKA). This hypothesis was tested in two intact smooth muscle preparations, the rat vas deferens and the bovine coronary artery, using exogenously applied cAMP and cAMP analogs. After 30 minutes of incubation, N⁶,2'-0-dibutyryl-cAMP (dBu-cAMP) (1 - 100 μM) inhibited phenylephrine (PE)-induced tension generation in the rat vas deferens in a dose-dependent manner. This analog (10 μM) also activated the soluble fraction of PKA but did not acti

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Alahuhta, M. (Markus). "Protein crystallography of triosephosphate isomerases: functional and protein engineering studies." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514287909.

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Abstract The aim of this PhD-study was to better understand the structure-function relationship of triosephosphate isomerase (TIM) and to use this expertise to change its substrate specificity. TIM is an important enzyme of the glycolytic pathway which catalyzes the interconversion of D-glyceraldehyde phosphate (D-GAP) and dihydroxyacetone phosphate (DHAP). Two main subjects are discussed: the engineering of monomeric TIM to create new substrate specificity and the structure-function relationship studies of the catalytically important mobile loop6. The starting point for the protein engineerin

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Guyony, Valerie. "Caractérisation et optimisation du procédé de cuisson extrusion humide de matières protéiques végétales pour ’obtention d’une texture fibreuse." Thesis, Nantes, Ecole nationale vétérinaire, 2020. http://www.theses.fr/2020ONIR149F.

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Dans un contexte d’essor de la consommation des protéines végétales, de nouveaux produits végétariens élaborés qui cherchent à imiter l’aspect, la texture et le goût des produits carnés ou analogues de viande ont vu le jour depuis les années 2000. Le procédé de transformation et de texturation utilisé pour ces protéines végétales est la cuisson extrusion. Cette thèse porte sur la texturation des protéines végétales par cuisson extrusion humide, et plus précisément sur l’optimisation de la fibration en vue d’imiter au plus près la texture fibreuse caractéristique de la viande. Les objectifs de

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Lugo-Mas, Priscilla. "Synthetic analogues of cysteinate-ligated non-heme iron enzymes : understanding the structure-function relationship of nitrile hydratase (NHase) and superoxide reductase (SOR) /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8635.

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Laricheva, Elena N. "Turning on Fluorescence in Silico: From Radical Cations to 11-cis Locked Rhodopsin Analogues." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1339787341.

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Koumanov, Françoise. "Evaluation biologique d'analogues iodés du glucose : étude de leurs interactions avec le transporteur." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10115.

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De nombreux etats pathologiques, tels le diabete, les maladies cerebrales, l'ischemie myocardique et le cancer, sont associes a des troubles dans le transport ou le metabolisme intracellulaire du glucose. L'appreciation in vivo chez l'homme des variations pathologiques de la captation du glucose revet donc une grande importance en medecine. Pour ces raisons nous avons oriente notre travail vers la recherche de nouveaux analogues du glucose marques a l'iode 123, un radioelement emetteur et utilisables dans tous les services de medecine nucleaire. Pour proceder a l'evaluation biologique de ces a

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