Academic literature on the topic 'Protein and peptide'

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Journal articles on the topic "Protein and peptide"

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Zhang, Yuqi, and Michel F. Sanner. "AutoDock CrankPep: combining folding and docking to predict protein–peptide complexes." Bioinformatics 35, no. 24 (2019): 5121–27. http://dx.doi.org/10.1093/bioinformatics/btz459.

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Abstract Motivation Protein–peptide interactions mediate a wide variety of cellular and biological functions. Methods for predicting these interactions have garnered a lot of interest over the past few years, as witnessed by the rapidly growing number of peptide-based therapeutic molecules currently in clinical trials. The size and flexibility of peptides has shown to be challenging for existing automated docking software programs. Results Here we present AutoDock CrankPep or ADCP in short, a novel approach to dock flexible peptides into rigid receptors. ADCP folds a peptide in the potential f
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Blaszczyk, Maciej, Maciej Pawel Ciemny, Andrzej Kolinski, Mateusz Kurcinski, and Sebastian Kmiecik. "Protein–peptide docking using CABS-dock and contact information." Briefings in Bioinformatics 20, no. 6 (2018): 2299–305. http://dx.doi.org/10.1093/bib/bby080.

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Abstract CABS-dock is a computational method for protein–peptide molecular docking that does not require predefinition of the binding site. The peptide is treated as fully flexible, while the protein backbone undergoes small fluctuations and, optionally, large-scale rearrangements. Here, we present a specific CABS-dock protocol that enhances the docking procedure using fragmentary information about protein–peptide contacts. The contact information is used to narrow down the search for the binding peptide pose to the proximity of the binding site. We used information on a single-chosen and rand
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Hamasaki, Naotaka, Hiroyuki Kuma, Kazuhisa Ota, Masao Sakaguchi, and Katsuyoshi Mihara. "A new concept in polytopic membrane proteins following from the study of band 3 protein." Biochemistry and Cell Biology 76, no. 5 (1998): 729–33. http://dx.doi.org/10.1139/o98-085.

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In the present communication, we introduce a novel concept in multispanning polytopic membrane proteins revealed by the study of the band 3 protein. The transmembrane domain of such proteins can be divided into three categories, that is, hydrophilic loops connecting transmembrane peptides (category 1), portions embedded by peptide-peptide interactions (category 2), and portions embedded by peptide-lipid interactions (category 3). Category 2 peptides of polytopic membrane proteins were found to stably reside in the lipid bilayer without peptide-lipid interactions that had been thought to be ess
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Kosugi, Takatsugu, and Masahito Ohue. "Design of Cyclic Peptides Targeting Protein–Protein Interactions Using AlphaFold." International Journal of Molecular Sciences 24, no. 17 (2023): 13257. http://dx.doi.org/10.3390/ijms241713257.

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More than 930,000 protein–protein interactions (PPIs) have been identified in recent years, but their physicochemical properties differ from conventional drug targets, complicating the use of conventional small molecules as modalities. Cyclic peptides are a promising modality for targeting PPIs, but it is difficult to predict the structure of a target protein–cyclic peptide complex or to design a cyclic peptide sequence that binds to the target protein using computational methods. Recently, AlphaFold with a cyclic offset has enabled predicting the structure of cyclic peptides, thereby enabling
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Lin, Wen-Wei, Yu-Jen Wang, Cheng-Wen Ko, Tain-Lu Cheng, and Yeng-Tseng Wang. "Cyclic Peptide Inhibitors of the Tsg101 UEV Protein Interactions Refined through Global Docking and Gaussian Accelerated Molecular Dynamics Simulations." Polymers 12, no. 10 (2020): 2235. http://dx.doi.org/10.3390/polym12102235.

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Tsg101 UEV domain proteins are potential targets for virus infection therapy, especially for HIV and Ebola viruses. Peptides are key in curbing virus transmission, and cyclic peptides have a greater survival time than their linear peptides. To date, the accurate prediction of cyclic peptide-protein receptors binding conformations still is challenging because of high peptide flexibility. Here, a useful approach combined the global peptide docking, Gaussian accelerated molecular dynamics (GaMD), two-dimensional (2D) potential of mean force (PMF), normal molecular dynamics (cMD), and solvated int
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Meyer, Katrina, and Matthias Selbach. "Peptide-based Interaction Proteomics." Molecular & Cellular Proteomics 19, no. 7 (2020): 1070–75. http://dx.doi.org/10.1074/mcp.r120.002034.

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Protein-protein interactions are often mediated by short linear motifs (SLiMs) that are located in intrinsically disordered regions (IDRs) of proteins. Interactions mediated by SLiMs are notoriously difficult to study, and many functionally relevant interactions likely remain to be uncovered. Recently, pull-downs with synthetic peptides in combination with quantitative mass spectrometry emerged as a powerful screening approach to study protein-protein interactions mediated by SLiMs. Specifically, arrays of synthetic peptides immobilized on cellulose membranes provide a scalable means to identi
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Li, Chun-Mei, Minna Haapalainen, Justin Lee, Thorsten Nürnberger, Martin Romantschuk, and Suvi Taira. "Harpin of Pseudomonas syringae pv. phaseolicola Harbors a Protein Binding Site." Molecular Plant-Microbe Interactions® 18, no. 1 (2005): 60–66. http://dx.doi.org/10.1094/mpmi-18-0060.

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Harpin HrpZ of plant-pathogenic bacterium Pseudomonas syringae elicits a hypersensitive response (HR) in some nonhost plants, but its function in the pathogenesis process is still obscure. HrpZ-interacting proteins were identified by screening a phage-display library of random peptides. HrpZ of the bean pathogen P. syringae pv. Phaseolicola (HrpZPph) shows affinity to peptides with a consensus amino acid motif W(L)ARWLL(G/L). To localize the peptide-binding site, the hrpZPph gene was mutagenized with randomly placed 15-bp insertions, and the mutant proteins were screened for the peptide-bindin
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TOOMIK, Reet, and Pia EK. "A potent and highly selective peptide substrate for protein kinase C assay." Biochemical Journal 322, no. 2 (1997): 455–60. http://dx.doi.org/10.1042/bj3220455.

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Protein kinases exhibit substrate specificities that are often primarily determined by the amino acids around the phosphorylation sites. Peptides corresponding to protein kinase C phosphorylation sites in several different proteins were synthesized on SPOTs membrane which has recently been found to be applicable for studies of protein kinase specificity. After phosphorylation with protein kinase C, we chose the best phosphorylated peptides for the investigation of the importance of amino acids immediately adjacent to the phosphorylation site. The selectivity of the best protein kinase C substr
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Schork, Karin, Michael Turewicz, Julian Uszkoreit, Jörg Rahnenführer, and Martin Eisenacher. "Characterization of peptide-protein relationships in protein ambiguity groups via bipartite graphs." PLOS ONE 17, no. 10 (2022): e0276401. http://dx.doi.org/10.1371/journal.pone.0276401.

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In bottom-up proteomics, proteins are enzymatically digested into peptides before measurement with mass spectrometry. The relationship between proteins and their corresponding peptides can be represented by bipartite graphs. We conduct a comprehensive analysis of bipartite graphs using quantified peptides from measured data sets as well as theoretical peptides from an in silico digestion of the corresponding complete taxonomic protein sequence databases. The aim of this study is to characterize and structure the different types of graphs that occur and to compare them between data sets. We obs
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Levin, E. R. "Natriuretic peptide C-receptor: more than a clearance receptor." American Journal of Physiology-Endocrinology and Metabolism 264, no. 4 (1993): E483—E489. http://dx.doi.org/10.1152/ajpendo.1993.264.4.e483.

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The natriuretic peptide family of proteins acts through two distinct classes of receptors that signal through entirely different mechanisms. The elucidation of the structure of the guanylate cyclase-containing receptor proteins has provided a better understanding of the mechanisms by which the natriuretic peptides regulate diverse functions of salt and water balance, in conjunction with other vasoactive peptides. A second receptor class was named for the originally described function of this protein to clear the natriuretic peptides from plasma. The mechanism of signaling for the natriuretic p
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Dissertations / Theses on the topic "Protein and peptide"

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Zhang, Zhiwen. "Towards peptide-binding peptides." Access restricted to users with UT Austin EID, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037037.

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Chen, Sharon S. "Peptide sequence assignments by probabilistic peptide profile matching to an annotated peptide database /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8084.

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Stevenson, Calum. "Database mining studies on protein-peptide and protein-protein interactions." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7644.

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A major area of interest is the identification of proteins that play a role in hormone dependent cancers and in collaboration with the MRC Centre for Reproductive Health we studied the gonadotropin releasing hormone receptor (GnRH-R). Other targets described in the thesis are the SH3 domain of PSD-95 and the protein BLyS. In order to identify potential inhibitory small molecules we have used a variety of computational data base mining approaches as well as using and developing experimental binding assays. It has become increasingly challenging to evaluate the most representative drug like smal
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Noble, J. E. "Fluorescent peptide substrates for protein phosphates and protein kinases." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406155.

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Bose, Christopher Cyril. "Peptide synthesis, protein folding and stability." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29644.

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The aim was to evaluate the effects of backbone substituents on the stability of protein domains. The substituents used were a variety of peptidomimetics and uncommon amino acids. The highly constrained substituents were introduced by total chemical synthesis using solid phase peptide synthesis techniques. Protein G B2 domain analogues containing 6-amino hexanoic acid, bisthiazolidine dipeptide (BTD), aminoisobutyric acid, D-proline and N-methyl alanine were made using (O- (7-Azahydroxybenzotriaz-1-yl)-1,1,3,3,- tetramethyl uronium hexafluorophosphate (HATU) as a coupling agent for hindered re
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Griffiths-Jones, Samuel R. "Peptide models for protein beta-sheets." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364650.

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Clare, Dominic Francis. "Computational studies of protein-peptide interactions." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445369/.

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The interactions between proteins and peptides in aqueous solution have been investigated using a classical molecular dynamics procedure with a molecular mechanical representation of the potential energy surface. During post-processing of the trajectory an implicit solvation method has been applied in order to calculate the free energy of each of the complex, protein and peptide structures in solution, allowing the binding free energy of the protein-peptide complex to be evaluated. Entropic contributions have been estimated using classical ideal gas thermodynamics. A program has also been deve
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Ja, William Wei-Hua Rees Douglas C. "Peptide modulators of G protein signaling /." Diss., Pasadena, Calif. : California Institute of Technology, 2005. http://resolver.caltech.edu/CaltechETD:etd-01032005-161114.

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Dean, Ryan. "Towards visible light switching of peptide-DNA and peptide-protein interactions." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/111805/.

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Peptides derived from DNA-binding zinc finger proteins were synthesised with pairs of cysteine residues with i,i+7 and i,i+11 relative spacings introduced into their sequence. The sidechains of these cysteine residues were then alkylated with the well-known water soluble photochrome 3,3’-bis(sulfo)-4,4’-bis(chloroacetamino) azobenzene (BSBCA). The change of shape of the azobenzene dye in these peptide-dye conjugates allowed photocontrol of peptide structure and thus peptide-DNA interactions. For a single zinc finger helix, UV irradiation yielded a peptide conjugate with a dissociation constant
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Beena, T. K. "Antigenic Determinants Of Chicken Riboflavin Carrier Protein: Structural And Functional Aspects." Thesis, Indian Institute of Science, 1994. https://etd.iisc.ac.in/handle/2005/141.

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Investigations detailed in this thesis constitute a part of the continuing programme of research undertaken in our laboratory on the riboflavin carrier protein (RCP) with partic­ular reference to identification and synthesis of neutralizing antigenic determinants, design of relevant epitope mimetics with improved immunogenic characteristics and relationship between their secondary structures and immunological properties. The riboflavin carrier protein is elaborated as a reproductive stratagem to ensure ade­quate vitamin deposition in the developing oocyte in the chickens. The protein is scrup
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Books on the topic "Protein and peptide"

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Schueler-Furman, Ora, and Nir London, eds. Modeling Peptide-Protein Interactions. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6798-8.

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Iranzo, Olga, and Ana Cecília Roque, eds. Peptide and Protein Engineering. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0720-6.

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Wolfgang, König. Peptide and protein hormones: Structure, regulation, activity :a reference manual. VCH, 1993.

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Ülo, Langel, ed. Introduction to peptides and proteins. Taylor & Francis, 2010.

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Ülo, Langel, ed. Introduction to peptides and proteins. Taylor & Francis, 2010.

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Walker, John M. Basic Protein and Peptide Protocols. Humana Press, 1994. http://dx.doi.org/10.1385/089603268x.

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1947-, Reid Ronald E., ed. Peptide and protein drug analysis. M. Dekker, 2000.

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Lee, Vincent H. L., 1951-, ed. Peptide and protein drug delivery. M. Dekker, 1991.

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1948-, Walker John M., ed. Basic protein and peptide protocols. Humana Press, 1994.

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Lee, Vincent. Peptide and Protein Drug Delivery. CRC Press, 2024. http://dx.doi.org/10.1201/9781003573715.

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Book chapters on the topic "Protein and peptide"

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Fothergill-Gilmore, Linda A. "Peptide Sequence Determination." In Protein Biotechnology. Humana Press, 1993. http://dx.doi.org/10.1007/978-1-59259-438-2_8.

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Kangueane, Pandjassarame, and Christina Nilofer. "HLA-Peptide Interaction to Short Peptide Vaccine Design." In Protein-Protein and Domain-Domain Interactions. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7347-2_15.

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Groves, Matthew R., and Irmgard Sinning. "Protein-Protein Interactions." In Peptide Arrays on Membrane Supports. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-09229-3_6.

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Jelonek, Marie T., Kannan Natarajan, and David H. Margulies. "Peptide-Protein Interactions." In Real-Time Analysis of Biomolecular Interactions. Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-66970-8_11.

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Soliman, Mohamed A. N., Abdulwahhab Khedr, and Mohamed A. Elsawy. "Peptide and Protein Emulsifiers." In Peptide Bionanomaterials. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-29360-3_13.

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Helmer, Dorothea, and Katja Schmitz. "Peptides and Peptide Analogs to Inhibit Protein-Protein Interactions." In Protein Targeting Compounds. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22473-2_8.

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Helmer, Dorothea, and Katja Schmitz. "Peptides and Peptide Analogs to Inhibit Protein-Protein Interactions." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32805-8_8.

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Rigter, Alan, Jan Priem, Drophatie Timmers-Parohi, Jan Pm Langeveld, and Alex Bossers. "Mapping Functional Prion–Prion Protein Interaction Sites Using Prion Protein Based Peptide-Arrays." In Peptide Microarrays. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-394-7_12.

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Kokoszka, Malgorzata E., and Brian K. Kay. "Mapping Protein–Protein Interactions with Phage-Displayed Combinatorial Peptide Libraries and Alanine Scanning." In Peptide Libraries. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2020-4_12.

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Rosenberg, Ian M. "Peptide Mapping and Microsequencing." In Protein Analysis and Purification. Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4757-1108-0_8.

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Conference papers on the topic "Protein and peptide"

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Newton, Ashley, and Kaustav Majumder. "Evaluating the Efficacy of Germination in Producing Biologically Active Peptides from Garbanzo Beans." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/czkw6895.

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Interest in plant-based protein, specifically pulse protein, has grown exponentially. Garbanzo beans (Cicer arietinum) have gained interest, as they are commonly consumed in many parts of the world. Bioactive peptides identified in pulse proteins have been shown to increase in concentration when exposed to various processing methods. Germination has been shown to decrease antinutritional factor concentration and increase production of enzymes, resulting in the production of peptides with potential bioactivity. This experiment aims to evaluate the efficacy of germination in producing and increa
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"Protein-Peptide Docking of Ebola Matrix Protein with Antimicrobial Peptides." In INTERNATIONAL CONFERENCE ON BIOLOGICAL RESEARCH AND APPLIED SCIENCE. Jinnah University for Women, 2025. https://doi.org/10.37962/ibras/2025/308-309.

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Qvit, Nir. "Engineered protein-protein interaction regulators for therapeutic applications." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.047.

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Foster, D., B. Schach, M. Rudinsky, et al. "The Effect of Changes in the Leader Sequence of Human Protein C on Biosynthetic Processing and Gamma-Carboxylation." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643648.

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Protein C is the precursor to a serine protease in plasma which contains gamma-carboxy glutamic acid and functions as a potent anticoagulant. Protein C shows considerable structural homology with the other vitamin K-dependent coagulation factors including prothrombin, factor VII, factor IX and factor X. This homology includes the putative pro-peptide region of the prepro leader sequences for these proteins, as well as the leader sequences for gamma-carboxylated proteins from bone. Deletion mutants have been constructed in the cDNA for human protein C in order to test the possibility that the p
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Kahler, Jan Pascal, Brecht D. Ellenbroek, and Sebastian Pomplun. "ReCHEMbinant protein engineering – synthetically enhanced protein therapeutics for Myc targeting." In 37th European Peptide Symposium. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p2107.

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Van holsbeeck, Kevin, Baptiste Fischer, Simon Gonzalez, et al. "Downsizing Nanobodies: Towards CDR Loop Mimetics Modulating Intracellular Protein-Protein Interactions." In 36th European Peptide Symposium. The European Peptide Society, 2022. http://dx.doi.org/10.17952/36eps.2022.141.

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Van holsbeeck, Kevin, Baptiste Fischer Fischer, Simon Gonzalez, et al. "Downsizing Nanobodies: Towards CDR Loop Mimetics Modulating Intracellular Protein-Protein Interactions." In 36th European Peptide Symposium. The European Peptide Society, 2022. http://dx.doi.org/10.17952/36eps/36eps.2022.141.

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Grob, Nathalie M., Clint Remarcik, Simon L. Rössler, et al. "Identification of reactivity hotspots at the interfaces of protein–protein interactions." In 37th European Peptide Symposium. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p1004.

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Foster, D., B. Schach, M. Rudisky, et al. "The Effect of Changes in the Leader Sequence of Human Protein C on Biosynthetic Processing and Gamma-Carboxylation." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643993.

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Protein C is the precursor to a serine protease in plasma which contains gamma-carboxy glutamic acid and functions as a potent anticoagulant. Protein C shows considerable structural homology with the other vitamin K-dependent coagulation factors including prothrombin, factor VII, factor IX and factor X. Sequence analysis ofthe cDNAs for these proteins has revealedthe presence of a prepro leader sequence that contains a pre sequence or hydrophobic signal sequence and a propeptide containing a number of highly conserved amino acids. The pre region is removed from thegrowing polypeptide chain by
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Mannes, Morgane, Charlotte Martin, Steven Ballet, Sarah Triest, Toon Laeremans, and Christel J. Menet. "Development of G Protein Peptidomimetics to Stabilize Active State G Protein-Coupled Receptors." In 36th European Peptide Symposium. The European Peptide Society, 2022. http://dx.doi.org/10.17952/36eps.2022.025.

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Reports on the topic "Protein and peptide"

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Daggett, Valerie. Simulation of Protein and Peptide-Based Biomaterials. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada399142.

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Lee, Jae-Hyung. Analysis of Protein-RNA and Protein-Peptide Interactions in Equine Infectious Anemia. Office of Scientific and Technical Information (OSTI), 2007. http://dx.doi.org/10.2172/933138.

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CONNECTICUT UNIV HEALTH CENTER FARMINGTON. Heat Shock Protein-Peptide Complexes as Anti-Viral Agents. Defense Technical Information Center, 1997. http://dx.doi.org/10.21236/ada325919.

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Wong, Eric A., and Zehava Uni. Nutrition of the Developing Chick Embryo: Nutrient Uptake Systems of the Yolk Sac Membrane and Embryonic Intestine. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697119.bard.

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We have examined the developmental changes in composition, amount, and uptake of yolk nutrients (fat, protein, water and carbohydrates) and the expression ofnutrient transporters in the yolk sac membrane (YSM) from embryonic day 11 (Ell) to 21 (E21) and small intestine from embryonic day 15 (E15) to E21 in embryos from young (22-25 wk) and old (45-50 wk) Cobb and Leghorn breeder flocks. The developmental expression profiles for the peptide transporter 1 (PepTl), the amino acid transporters, EAAT3, CAT-1 and BOAT, the sodium glucose transporter (SGLTl), the fructose transporter (GLUT5), the dig
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Yu, Dihua. Novel Peptide/Protein Delivery System Targeting erbB2-Overexpressing Breast Cancer Cells. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada396880.

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Yu, Dihua. Novel Peptide/Protein Delivery System Targeting erbB2-Overexpressing Breast Cancer Cells. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada409871.

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Yu, Dihau. Novel Peptide/Protein Delivery System Targeting erbB2-Overexpressing Breast Cancer Cells. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada390463.

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Rohrbough, James G., Linda Breci, Nirav Merchant, Susan Miller, and Paul A. Haynes. Verification of Single-Peptide Protein Identifications by the Application of Complementary Database Search Algorithms. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada439637.

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Penn, Linda Z. Exploiting the Novel Repressed Transactivator Assay to Identify Protein Peptide Inhibitors of the Myc Oncoprotein. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada436402.

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Subjeck, John. Use of the HSP 110 Peptide Binding Protein for the Development of New Breast Cancer Vaccines. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada393271.

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