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Dissertations / Theses on the topic 'Protein assemblies'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Wicky, Basile Isidore Martin. "Biophysical studies of protein assemblies." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288004.

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Proteins are synthesised as linear polymeric chains. The subtle energetic interplay of interatomic interactions results in chain folding, through which proteins may acquire defined structures. This spatial organisation is encoded by the protein sequence itself; the so-called thermodynamic hypothesis formulated by Anfinsen in 1961. A defined structure is often considered a pre-requisite to protein function, but widespread existence of intrinsically disordered proteins (IDPs) has prompted a re- evaluation of the ways biological function may be encoded into polypeptide chains. Furthermore, protei

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2

Turzo, SM Bargeen Alam. "Computational Investigation of Protein Assemblies." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1532714714406789.

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3

Bayro, Marvin J. "Protein MAS NMR methodology and structural analysis of protein assemblies." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57800.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Methodological developments and applications of solid-state magic-angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy, with particular emphasis on the analysis of protein structure, are described in this thesis. MAS NMR studies of biomolecules ranging from model peptides and proteins in crystalline form to amyloid fibrils and whole bacterial organelles are reported. The methods presented include novel pulse sequ

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4

Norville, Julie Erin 1980. "Synthetic scaffolds and protein assemblies for engineering applications." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28737.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.<br>Includes bibliographical references (p. 57-63).<br>S-layer proteins, which naturally self-assemble on the exterior of cells, provide an interesting basis for the creation of synthetic scaffolds. In this thesis, I created a plasmid which produces a recombinant form of a well characterized S layer protein, sbpA, which has a number of properties ideal for nanotechnology applications. I also explored purification of both the native and recombinant forms of sbpA. Together these preli

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5

Bagheri, Mehran. "Intrinsically Disordered Proteins: Mechanics, Assemblies, and Structural Transitions." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36576.

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Proteins are essential parts of living organisms that initiate and control almost all cellular processes. Despite the widely accepted belief that all functional proteins fold into stable and well-defined three-dimensional (3D) structures mandatory for protein activity, the existence of biologically functional disordered proteins has been increasingly recognized during past two decades. Proteins with inherent structural disorder, commonly known as intrinsically disordered proteins (IDPs), play many roles in a biological context. However, in contrast to their folded counterparts, they are dynami

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6

Mancl, Jordan Michael. "Molecular Investigations of Protein Assemblies Involved in Prokaryotic Virulence." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/102298.

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Protein complexes mediate a diverse range of behavior in prokaryotic cells, yet the exact molecular mechanisms explaining how many of these complexes assemble and function remain unknown. This work focuses on understanding the molecular mechanisms of two different protein assemblies responsible for regulating virulence in the opportunistic pathogen Pseudomonas aeruginosa. P. aeruginosa utilizes type IV pili (T4P) to adhere to, and move along, surfaces. Assembly of T4P is powered by a dedicated cytoplasmic ATPase, PilB. The structural study of PilB from a related system (chapter 2) resulted in

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7

Choi, Ucheor B. "Single molecule fluorescence reveals dynamic structures of SNARE protein assemblies." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-07092009-120330/.

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Conformational information about proteins can often reveal the mechanisms of their biological functions. This thesis examines conformational aspects of the synaptic SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein complex that is essential for membrane fusion leading to Ca2+ triggered neurotransmitter release. Biochemical and high-resolution structural studies of SNARE proteins and several different assemblies of these proteins have provided a foundation for our understanding of neurotransmitter release, but the exact mechanisms these protein machines use

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8

Ruiz, Arlandis Gemma. "Binding and internalization of exogenous protein assemblies by mammalian cells." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114814.

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Le mépliement et l'agrégation des protéines sont à l'origine de nombreuses maladies neurodégénératives, dont la maladie de Huntington (HD) et la maladie de Parkinson (PD). Même si l’agrégation de différentes protéines liées à des maladies est bien documentée, on en sait peu sur l'interaction entre les protéines mal repliées et les cellules neuronales, qui leur permettent de se propager et affecter différentes régions du cerveau. L'objectif de ma thèse était de générer des modèles cellulaires rapporteurs de la huntingtine et l’α-synucléine, protéines dont le mauvais repliement et l'agrégation s

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9

Ellis, Vicky-June. "Design and Synthesis of Multivalent Dendritic Assemblies for the Treatment of Cancer." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/366378.

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The importance of protein-protein interactions in regulating key biological processes, particularly in relation to apoptotic regulation and cancer, has provided many challenges for traditional small molecule approaches to drug development. Historically, the majority of small molecules targeted at protein-protein interfaces have been unable to provide the tight binding affinities and steric bulk required to disrupt such interactions, as they often occur along flat and extended protein surfaces. In this work we have investigated the combination of peptide-based therapeutics, with modularly const

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10

Vigers, G. P. A. "Clathrin assemblies in vitreous ice : A structural analysis by image reconstruction." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377261.

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11

Persson, Karina. "Structural studies of protein assemblies : MHC class I and lumazine synthase /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5499-9.pdf.

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12

Qi, Zhe. "Peptide and Protein Supramolecular Assemblies Studied by Solid-State NMR Spectroscopy." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492532128985232.

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13

Radford, Sheena Elizabeth. "Domains and conformational flexibility in the catalytic mechanism of the 2-oxo acid dehydrogenase complexes." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236036.

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The structure of the dihydrolipoamide acetyltransferase (E2p) component of the pyruvate dehydrogenase complex from <i>Escherichia coli</i> and its role in catalysis were studied by the combined approaches of protein engineering, limited proteolysis and <SUP>1</SUP>H-n.m.r. spectroscopy. Genetic reconstruction of the E2p component (performed elsewhere) produced a series of mutant complexes assembled around E2p chains which contain only a single lipoyl domain and an associated (alanine+proline)-rich linker region of gradually diminishing lengths (32, 20, 13, 7 and 1 residue(s), respectively, in

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14

McCammon, Margaret Gallacher. "Non-covalent interactions in multi-subunit protein assemblies : a mass spectrometry investigation." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393604.

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15

Bohl, Jan. "Characterisation of non-covalent PrP assemblies." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS284.

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L’étude de l’interaction entre des protéines et leurs ligands est essentielle pour la compréhension de leur rôle physiologique ainsi que de leur rôle dans la mise en place de pathologies. En particulier, dans le cas de maladies neurodégénératives, comme les maladies d’Alzheimer ou de Creutzfeld-Jacob, ou d’autres pathologies liées au mépliement de protéines, la compréhension des interactions entre protéines, qui peuvent modifier de façon considérable le paysage conformationnel des partenaires, est une des clés pour décrypter les étapes moléculaires élémentaires induisant une cascade d’événemen

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16

Giraudon--Colas, Gaël. "Caractérisation multiéchelle d'assemblages d'hémoglobine : de l'adsorption sur les nanoparticules aux gels nanocomposites Protein−Nanoparticle Interactions: What Are the Protein−Corona Thickness and Organization? In Situ Analysis of Weakly Bound Proteins Reveals Molecular Basis of Soft Corona Formation." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASF011.

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Les gels de protéine nanocomposites sont un sujet encore peu développé dans la littérature malgré de nombreuses applications allant de l’immobilisation d’enzyme aux prothèses en passant par les gels alimentaires. La protéine permet d’assurer la biocompatibilité des gels tandis que l’ajout des nanoparticules a pour but de moduler les propriétés mécaniques des gels. Nous avons donc décidé de nous intéresser aux gels d’hémoglobine réticulée chimiquement et dopés aux nanoparticules. L’hémoglobine (Hb) a été choisie pour sa grande abondance et ses propriétés de fixation du dioxygène. Les gels seron

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17

Mauk, Andrew W. "A new modeling protocol for G-protein coupled receptors : molecular simulation of phospholipid assemblies." Thesis, Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/11033.

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18

Serrão, Vitor Hugo Balasco. "Complexos macromoleculares da via específica de incorporação de selênio de Escherichia coli." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-20032013-091148/.

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A existência de uma maior variedade de aminoácidos codificados pelo código genético tem estimado estudos sobre os mecanismos de síntese, reconhecimento e incorporação desses resíduos nas cadeias polipeptídicas nascentes. Um exemplo é a via de incorporação de selenocisteína evento cotraducional dirigido pelo códon UGA. Em bactérias, essa via conta com uma complexa maquinaria molecular composta por: Selenocisteína Sintase (SelA), Fator de Elongação Específico de Reconhecimento (SelB), Selenofosfato Sintetase (SelD), tRNA específico (SelC ou tRNAsec), sequência específica no mRNA (Sequência de In

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19

Morou, Besong David Tabot. "On the hydrodynamic properties of IgG1 glycoforms in comparison with pure protein and pure carbohydrate assemblies." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594775.

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Biological macromolecules are routinely exposed to various stresses during production, processing, transport and storage. Inadvertently, this may ultimately result in protein inactivation, denaturation and aggregation. The objective of the present study was to investigate the stability or instability which can occur fo llowing routine bio-processing of phannaceutical and other protein preparations with different levels of glycosylation, in addition to two polysaccharide samples of significant importance to the food industry. Using hydrodynamic techniques, the effects of physico-chemical factor

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20

Jones, Christopher Michael. "Characterization of Macromolecular Protein Assemblies by Collision-Induced and Surface-Induced Dissociation: Expanding the Role of Mass Spectrometry in Structural Biology." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193581.

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This dissertation presents an investigation into the structure of macromolecular protein assemblies by mass spectrometry. The experiments described within are designed to systematically assess the analytical utility of surface-induced dissociation (SID) tandem mass spectrometry in the characterization of multi-subunit protein complexes. This is accomplished by studying the effects of ion-surface collision on the fragmentation products of protein assemblies that vary by mass, number of subunits, and protein structural features. The dissociation energetics and mechanisms of protein complexes are

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21

Yang, Liu [Verfasser], and Angelika [Akademischer Betreuer] Noegel. "Functional characterization of LINC complex protein assemblies and their role in laminopathies / Liu Yang. Gutachter: Angelika Noegel." Köln : Universitäts- und Stadtbibliothek Köln, 2013. http://d-nb.info/1038555302/34.

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22

Schmidt, Carla [Verfasser], Henning [Akademischer Betreuer] Urlaub, and Ralf [Akademischer Betreuer] Ficner. "Absolute and relative quantification of proteins in large protein-RNA assemblies by mass spectrometry / Carla Schmidt. Gutachter: Henning Urlaub ; Ralf Ficner. Betreuer: Henning Urlaub." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2010. http://d-nb.info/1043612351/34.

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23

Mas, Guillaume. "Etude structurale et fonctionnelle par RMN d'une chaperonine de 1 MDa en action." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV036/document.

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Les chaperonines sont des chaperonnes moléculaires indispensables pour le repliement de certaines protéines dans les cellules. La taille et la complexité de ces machineries biologiques rendent complexes l'étude de leurs propriétés structurales et fonctionnelles. La spectroscopie RMN permet de suivre des changements structuraux et dynamiques en temps réel avec une résolution atomique. Cependant, l'étude par RMN de protéines ou de complexes de haut poids moléculaires a été un challenge pendant de nombreuses années. Dans la première partie de cette thèse, il a été montré que la combinaison de mar

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24

Levchenko, Mariia [Verfasser], Peter [Akademischer Betreuer] [Gutachter] Rehling, and Blanche [Gutachter] Schwappach. "Mitochondrial protein assemblies: Biogenesis of the cytochrome c oxidase and mitophagic signaling complexes / Mariia Levchenko. Betreuer: Peter Rehling. Gutachter: Peter Rehling ; Blanche Schwappach." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1113288779/34.

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25

Aberkane, Leïla. "Etude des mécanismes de structuration d’assemblages β-lactoglobuline-gomme d’Acacia en présence d’un flavonoïde, la quercétine". Thesis, Vandoeuvre-les-Nancy, INPL, 2010. http://www.theses.fr/2010INPL045N/document.

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Les flavonoïdes sont des ingrédients prometteurs pour différentes applications alimentaires et non alimentaires, grâce à leurs propriétés antioxydantes et biologiques. Cependant, la formulation de ces molécules est difficile à réaliser en raison de leur faible solubilité dans la plupart des solvants. Afin de remédier à cette difficulté, l’approche suivie dans cette étude est l’incorporation des flavonoïdes dans des particules à base de biopolymères (protéine-polysaccharide), stables et fonctionnelles. Le principal objectif de cette thèse était d’acquérir des connaissances à différentes échelle

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26

Patel, Ankit Rajnikant. "Probing tethered vesicle assemblies using quartz crystal microbalance with dissipation monitoring : antibody binding and other applications towards ex vivo, label-free membrane protein analysis /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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27

Baas, Tracey Lynn. "The design, synthesis, and characterization of template assembled synthetic proteins /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/11561.

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28

Keegan, Neil. "From engineered membrane proteins to self-assembling protein monolayers." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419991.

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29

Grafe, Marianne [Verfasser], Ralph [Akademischer Betreuer] Gräf, Carsten [Akademischer Betreuer] Beta, Ralph [Gutachter] Gräf, Salvatore [Gutachter] Chiantia, and Georg [Gutachter] Krohne. "Analysis of supramolecular assemblies of NE81, the first lamin protein in a non-metazoan organism / Marianne Erika Grafe ; Gutachter: Ralph Gräf, Salvatore Chiantia, Georg Krohne ; Ralph Gräf, Carsten Beta." Potsdam : Universität Potsdam, 2019. http://d-nb.info/1218405430/34.

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Grafe, Marianne [Verfasser], Ralph [Akademischer Betreuer] Gräf, Carsten Akademischer Betreuer] Beta, Ralph [Gutachter] Gräf, Salvatore [Gutachter] Chiantia, and Georg [Gutachter] [Krohne. "Analysis of supramolecular assemblies of NE81, the first lamin protein in a non-metazoan organism / Marianne Erika Grafe ; Gutachter: Ralph Gräf, Salvatore Chiantia, Georg Krohne ; Ralph Gräf, Carsten Beta." Potsdam : Universität Potsdam, 2019. http://d-nb.info/1218405430/34.

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31

Grafe, Marianne Erika [Verfasser], Ralph [Akademischer Betreuer] Gräf, Carsten [Akademischer Betreuer] Beta, Ralph [Gutachter] Gräf, Salvatore [Gutachter] Chiantia, and Georg [Gutachter] Krohne. "Analysis of supramolecular assemblies of NE81, the first lamin protein in a non-metazoan organism / Marianne Erika Grafe ; Gutachter: Ralph Gräf, Salvatore Chiantia, Georg Krohne ; Ralph Gräf, Carsten Beta." Potsdam : Universität Potsdam, 2019. http://d-nb.info/1218405430/34.

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32

Agarwal, Deepesh. "Sur quelques problèmes algorithmiques relatifs à la détermination de structure à partir de données de spectrométrie de masse." Thesis, Nice, 2015. http://www.theses.fr/2015NICE4048/document.

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La spectrométrie de masse, initialement développée pour de petites molécules, a permis au cours de la dernière écoulée d’étudier en phase gazeuse des assemblages macro-moléculaires intacts, posant nombre de questions algorithmiques difficiles, dont trois sont étudiées dans cette thèse. La première contribution concerne la détermination de stoichiométrie (SD), et vise à trouver le nombre de copies de chaque constituant dans un assemblage. On étudie le cas où la masse cible se trouve dans un intervalle dont les bornes rendent compte des incertitudes des mesures des masses. Nous présentons un alg

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33

Stojko, Johann. "Nouvelles méthodologies en spectrométrie de masse native et mobilité ionique pour la caractérisation structurale de macrobiomolécules et de leurs complexes associés." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF003/document.

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Ce travail de thèse porte sur le développement de méthodes en spectrométrie de masse (MS) et mobilité ionique (IM-MS) supramoléculaires pour la caractérisation fine de complexes protéine-ligand et d’assemblages protéiques hétérogènes de hauts poids moléculaires. L’optimisation instrumentale apportée à l’étude de ces systèmes, permet d’étendre le potentiel de ces deux approches en biologie structurale. Le criblage de complexes protéine-ligand permet ici une détermination de leurs propriétés d’interaction et la mise en évidence de subtils changements de conformation induits, pouvant être suivis

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Díaz, Ocaña Raquel. "Recombinant self-assembling nanoparticles for cancer therapy based on toxin and venom compounds." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670483.

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La plataforma desenvolupada d’enginyeria de proteïnes auto-acoblables permet dissenyar nanopartícules únicament proteiques (NPs) capaces d’atacar i actuar selectivament sobre les cèl.lules canceroses mitjançant la interacció amb receptors que es sobreexpressen. Les estructures esfèriques estables de les NPs desenvolupades i la seva mida adequada, en combinació amb els pèptids d’orientació , milloren la seva especificitat. A més, la incorporació de segments de toxina i verí ha millorat els efectes terapèutics d’aquestes estructures que són totalment biocompatibles i que no tenen cap portador ex

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Albers, Willem M. "Immobilisation of biomolecules onto organised molecular assemblies /." Espoo [Finland] : Technical Research Centre of Finland, 1999. http://www.vtt.fi/inf/pdf/publications/1999/P391.pdf.

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Littlejohn, Jacob James. "Peroxiredoxins : a model for a self-assembling nanoscale system." Thesis, University of Canterbury. School of Biological Sciences, 2012. http://hdl.handle.net/10092/10731.

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The formation of large, complex structures from small building blocks through self-assembly is widely seen in proteins and provides a tool for the creation of functional nanoscale devices. However, the factors controlling protein self-assembly are complex and often poorly understood. Peroxiredoxins are a large family of proteins, many of which are able to form a variety of large structures from a small, basic unit. This assembly has been shown to be strongly influenced by the redox state of the enzyme, which functions as a switch, controlling self-assembly. This thesis uses a protein from this

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Walters, Chris. "Hydrodynamic studies on chaperonins and related molecular assemblies." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368342.

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Soon, Allyson Shook Ching. "Exploiting fibrin knob:hole interactions for the control of fibrin polymerization." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45917.

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The minimization of blood loss represents a significant clinical need in the arena of surgery, trauma, and emergency response medicine. Fibrinogen is our body's native polymer system activated in response to tissue and vasculature injury, and forms the foundation of the most widely employed surgical sealant and hemostatic agent. Non-covalent knob:hole interactions are central to the assembly of fibrin that leads to network and clot formation. This project exploits these affinity interactions as a strategy to direct fibrin polymerization dynamics and network structure so as to develop a tempera

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Zhang, Le. "Bioinspired matrices assembled by polysaccharide-protein interactions." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 213 p, 2008. http://proquest.umi.com/pqdweb?did=1456296201&sid=3&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Valkov, Eugene. "Design and analysis of self-assembling protein systems." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670100.

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Nilsson, Josefina. "Protein adaptability involved in self-assembled icosahedral capsids /." Stockholm : Department of biosciences and nutrition, Center for biotechnology, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-717-0/.

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Carter, Nathan Andrew. "Design Strategies for Dynamic Self-assembled Protein Materials." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/93207.

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Structures in nature exhibit unique and complex architectures whose order propagates from nano- (10-9 m) to macro-scales (mm to m). These structures give rise to a rich diversity of adaptive function that allows for life in all environments on Earth. This complex functionality has driven research into bio-inspired materials where scientists investigate the complex relationship between sequence, structure and function of these materials. A good illustrative example of the effect that hierarchical structure can have is a brick wall. Bricks are laid so that the layer on top is shifted in either d

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Cisneros, Armas David Alejandro. "Molecular assemblies observed by atomic force microscopy." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1182777560689-53566.

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We use time-lapse AFM to visualize collagen fibrils self-assembly. A solution of acid-solubilized collagen was injected into the AFM fluid cell and fibril formation was observed in vitro. Single fibrils continuously grew and fused with each other until the supporting surface was completely covered by a nanoscopically well-defined collagen matrix. Laterally, the fibrils grew in steps of ~4 nm suggesting a two-step mechanism. In a first step, collagen molecules associated together. In the second step, these molecules rearranged into a structure called a microfibril. High-resolution AFM topograph

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Stevens, Marryat. "Exploiting the assembly of designed self-assembling protein structures." Thesis, University of Sussex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426313.

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Skoda, Maximilian W. A. "Interaction of proteins with oligo(ethylene glycol) self-assembled monolayers." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:e36c47f8-1afc-4655-a84a-05bd06d0e45f.

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The aim of this thesis is the study of protein resistant oligo(ethylene glycol) (OEG) self-assembled monolayers (SAMs) using in situ techniques, such as neutron reflectivity (NR), polarisation modulation infrared spectroscopy (PMIR) and small-angle x-ray scattering (SAXS). In order to elucidate the mechanisms that lead to the nonfouling properties of these SAMs, the SAM-water, protein-protein and protein-SAM interactions have been studied separately. NR measurements, focused on the solid-liquid interface between OEG SAMs and water, show clear evidence of an extended layer with reduced density

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Niu, Lijiang. "Investigating self-assembled protein nanotubes using atomic force microscopy." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10777/.

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Self-assembled protein nanotubular materials are attractive as putative building blocks for a variety of applications. Knowledge of the three-dimensional structures and the physical properties of these protein nanotubes then becomes a prerequisite for their use in rational materials design. The main purpose of the work presented in this thesis is to investigate both the structural and mechanical properties of protein nanotubes utilizing atomic force microscopy (AFM). Several different protein nanotubes will be used as exemplars to develop AFM methods. AFM is capable of both visualizing and mon

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Serna, Romero Naroa. "Development of self-assembling protein only nanoparticles for targeted therapies." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/662777.

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Las medicinas innovadoras demandan con urgencia nuevos vehículos funcionales para la entrega dirigida de fármacos convencionales y novedosos, preferentemente en forma de nanopartículas. Los materiales nanoestructurados mejoran la biodistribución y la penetración celular, lo que les convierten en transportadores eficaces de fármacos, que con un rango de tamaño entre 6 y 100 nm escapan al filtrado renal. La arquitectura de estos nanoconjugados vehículo-fármaco debe ser lo suficientemente estable para permitir la circulación sistémica y la entrega específica en los tejidos diana, reduciendo as

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Lei, Stephen. "Economic Feasibility of Assembling Grade-A Milk by Protein Content." DigitalCommons@USU, 1988. https://digitalcommons.usu.edu/etd/4082.

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This thesis consisted of two computerized simulations of assembling milk from dairy farms and distributing it to milk plants, using TRUCKSTOPS, a commercial truck routing computer program. In the first simulation milk was assembled and delivered to the nearest available plant without regard to protein content, with the high-protein milk delivered to manufacturing plants. Doing so increased the fat and protein in milk delivered to manufacturing plants, and increased cheese production 2.6 percent. It also increased assembly costs and lowered fat and protein in milk delivered to fluid milk plants

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Pincemaille, Justine. "Interactions et assemblages de prolamines du blé." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTG056/document.

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Ce travail de thèse vise à apporter des connaissances structurales et fonctionnelles sur les protéines du gluten. Pour cela, nous utilisons les concepts et méthodes de la physique des polymères et de la matière molle. Plus précisément, nous optimisons un protocole d’extraction basé sur la séparation de phases liquide-liquide. Ce dernier permet d’obtenir des isolats de protéines à différents rapports massiques gluténines/gliadines que nous étudions ensuite dans un solvant eau/éthanol 50/50 (v/v). Les résultats, montrent que les protéines se comportent comme des chaînes de polymères en solvant θ

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GRENGA, LUCIA. "Study of the biological role of the protein-protein interaction in the divisome assembling and functionality." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/202281.

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L’incremento delle infezioni causate da batteri resistenti alle attuali terapie e la scarsità di farmaci efficaci per il loro trattamento spingono la comunità scientifica a cercare strategie innovative, per identificare nuove classi di farmaci antibatterici. Un modo per raggiungere questo obiettivo è quello di sviluppare farmaci che hanno nuovi meccanismi d’azione. Diverse caratteristiche delle proteine dell’apparato di divisione (o divisoma) batterico suggeriscono che esse potrebbero essere dei bersagli ideali per nuovi antimicrobici. Poiché la divisione cellulare richiede molteplici interaz

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