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Dissertations / Theses on the topic 'Protein biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Scior, Annika [Verfasser]. "Protein Quality Control during Protein Biosynthesis / Annika Scior." Konstanz : Bibliothek der Universität Konstanz, 2013. http://d-nb.info/1096331527/34.

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2

Worthington, Andrew Schuyler. "Chemoenzymatic investigations of protein-protein interactions in carrier protein-mediated biosynthesis." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3338769.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed January 9, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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3

Hollingshead, Sarah Louise. "Investigating protein-protein interactions in the chlorophyll biosynthesis pathway." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6488/.

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The production of chemical energy from light energy is arguably the most important reaction known, which makes photosynthesis one of the most important processes on Earth. Nearly all life depends on the energy derived from light, and it is this process that supports Earths oxygenated atmosphere. Photosynthesis is initiated by the absorption of light, which is performed by specialised pigment molecules known as the chlorophylls. These are highly specialised pigment molecules that belong to the tetrapyrrole family, which also includes vitamin B12, sirohaem and haem. Chlorophyll is synthesised vi

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4

Deiorio-Haggar, Kaila. "RNA structures regulating ribosomal protein biosynthesis." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104628.

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Thesis advisor: Michelle M. Meyer<br>Most commonly known for being the blueprint for proteins, RNA also plays vital roles in gene regulation. Non-coding RNAs, functional RNA molecules that are not translated into proteins, are potential regulatory agents in bacteria. Ribosomal autogenous regulatory elements are short transcribed sequences between the promoter and a protein coding region that regulate expression of their associated gene(s), though they are not themselves translated. These sequences form RNA secondary structures that can regulate at either the transcriptional or translational le

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5

Rone, Malena Beth. "Role of protein-protein interactions in protein import, cholesterol transport and steroid biosynthesis." Connect to Electronic Thesis (CONTENTdm), 2010. http://worldcat.org/oclc/642829125/viewonline.

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6

Guna, Alina-Ioana. "Membrane protein biosynthesis at the endoplasmic reticulum." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276678.

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The biosynthesis of integral membrane proteins (IMPs) is an essential cellular process. IMPs comprise roughly 20-30% of the protein coding genes of all organisms, nearly all of which are inserted and assembled at the endoplasmic reticulum (ER). The defining structural feature of IMPs is one or more transmembrane domains (TMDs). TMDs are typically stretches of predominately hydrophobic amino acids that span the lipid bilayer of biological membranes as an alpha helix. TMDs are remarkably diverse in terms of their topological and biophysical properties. In order to accommodate this diversity, the

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7

Busse, Marta. "EXT Proteins in Heparan Sulfate Biosynthesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6303.

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8

Gurcha, Sudagar Singh. "Mannan biosynthesis in mycobacterium tuberculosis." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324798.

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9

Walker, Douglas Gordon. "Characterization of immediate-early and early proteins of murine cytomegalovirus synthesized in permissive and nonpermissive cells." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25985.

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The gene products produced by murine cytomegalovirus (MCMV) in infected cells prior to viral DNA synthesis are believed to control the interaction of the virus with the cells, determining whether a permissive infection results, with virus replication, or whether further virus gene expression is inhibited, resulting in a latent or abortive infection. The aim of this study was to characterize the early viral gene products that are produced in permissive and nonpermissive cells. The proteins produced in 3T3-L1 cells, permissively infected with MCMV, during the first six hours of infection (the p

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10

Davies, Holly Gibs. "MSY4, a sequence-specific RNA binding protein expressed during mouse spermatogenesis /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/10307.

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11

Gillespie, Charles Stewart. "Myelin membrane protein biosynthesis : an in vitro study." Thesis, University of Stirling, 1988. http://hdl.handle.net/1893/22868.

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The sites of biosynthesis and incorporation of the abundant CNS myelin proteins 2' , 3' -cyclic nucleotide-3'-phosphodiesterase (CNPase) and P2 protein into the growing myelin membrane were investigated. Cell-free translation systems programmed with mRNA from rat brain, rabbit spinal cord, free and bound polysomes and purified myelin demonstrated conclusively that both CNPase and P2 are synthesized on free polysomes like the myelin basic proteins (MBPs) but unlike the proteolipid protein (PLP), the major intrinsic membrane protein of CNS myelin, which is known to be synthesized at the oligoden

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12

Wallock-Richards, Daynea Juaneckah. "Natural products : biosynthesis, antimicrobial properties and protein targets." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/14188.

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The diversity of biosynthetic pathways in prokaryotes and eukaryotes has led to numerous bioactive natural products (NPs) which occupy a vast chemical space. Despite the current challenges in NP research, these molecules are still relevant today as they are a major source of human medicine as well as being useful biological tools. The elucidation of their biosynthetic pathways has also provided information about the biochemical and biophysical properties of fascinating enzyme families such as the α- oxoamine synthases (AOSs). The AOSs are an expanding group of pyridoxal 5’- phosphate (PLP)-dep

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13

Tang, Norina Mei Ngon. "Regulation of protein synthesis and induction of oncogenesis by a cellular protein kinase inhibitor /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/11501.

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14

Jack, Colin C. "MOLECULAR CLONING AND PROTEIN BIOSYNTHESIS OF MATRIX METALLOPROTEINASE-7." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1430758756.

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15

Hansen, Maureen Elizabeth Kieber Joseph J. "Regulation of ethylene biosynthesis via ACC synthase protein stability." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1865.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.

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16

Addy, Christine. "The biochemical and structural basis of transcription regulation by CysB protein." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301687.

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17

Gustafsson, Magnus. "Palmitoylation and amyloid fibril formation of lung surfactant protein C /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4386-9/.

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18

Wu, Cheng. "Study of translational control using cell-free translation systems and primer extension inhibition assays / Cheng Wu." Full text open access at:, 2008. http://content.ohsu.edu/u?/etd,624.

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19

Yan, Weisi. "Functional proteomic study of Akt reveals novel substrates in translation /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1619246521&sid=9&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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20

behera, Jyoti R., and aruna Ranjan kilaru. "NOVEL STRUCTURAL CHARACTERISTICS OF OIL BIOSYNTHESIS REGULATOR PROTEIN IN AVOCADO." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/21.

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Plants synthesize and store oil, mostly triacylglycerol (TAG), in various storage tissues that serves as a source of carbon and energy. The process is transcriptionally controlled by WRINKLED1 (WRI1), a member of the APETALA2 (AP2) class of transcription factors, that regulates most of the fatty acid biosynthesis genes. Among the four Arabidopsis WRI1 paralogs, only WRI2 is nonfunctional and failed to complement wri1-1 mutant seeds. The oleaginous Avocado (Persea americana) fruit mesocarp (60-70% DW oil) showed high expression levels for orthologs of WRI2, along with WRI1 and WRI3. While the r

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21

Giorgini, Flaviano. "Functional analysis of the murine sequence-specific RNA binding protein MSY4 /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/10293.

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22

Tesfa-Selase, Fisehaye. "Regulation of the gua operon of Escherichia coli by the DnaA protein." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385344.

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23

Liu, Jia. "Increased hexosamine biosynthesis and protein O-GLCNAC protect isolated rat heart from ischemia/reperfusion injury." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2006. http://www.mhsl.uab.edu/dt/2006p/liu.pdf.

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24

Dunn, Angela D. "Probing the cellular role of protein disulphide isomerase in Saccharomyces cerevisiae." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242861.

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25

Zhong, Jun. "A double-stranded RNA binding protein that is important for murine spermatogenesis and growth /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/10301.

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26

Bouakaz, Lamine. "Versatile Implementations of an Improved Cell-Free System for Protein Biosynthesis : Functional and structural studies of ribosomal protein L11 and class II release factor RF3. Novel biotechnological approach for continuous protein biosynthesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6325.

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27

Singh, A. K. "Studies on the diterpenes of Helianthus annuus : identification of a new gibberellin and preparation of protein conjugates of kaurenoids." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376496.

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28

Evans, Simon E. "NMR Investigation into the Role of Acyl Carrier Protein in Polyketide Biosynthesis." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486136.

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Acyl carrier proteins (ACPs) are essential to both the fatty acid (FAS) and polyketide (PKS) biosynthetic pathways, yet relatively little is known about how they function at a molecular level. Starting from the published solution NMR structure of actinorhodin (act) PKS ACP from Streptomyces coeHc%r, a program of work to extend the understanding of ACP's role in polyketide biosynthesis has been undertaken. To this end, nine different ACP derivatives have been synthesised and structurally characterised by NMR. Established methods for the growth, expression, and purification of ACP have been exte

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29

Della, Marina. "Heat shock protein 47(HSP47) : a multifunctional molecular chaperone for collagen biosynthesis." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251954.

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30

Ladds, Simon John. "The upregulation of neutrophil protein biosynthesis in response to GM-CSF stimulation." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366718.

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31

Han, Ling Zhang Shuqun. "Regulation of ethylene biosynthesis by mitogen-activated protein kinase cascades in Arabidopsis." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/6293.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb. 12, 2008). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dr. Shuqun Zhang, Thesis Supervisor. Vita. Includes bibliographical references.

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32

Young, Clare Elisabeth. "Examination of the Brassica napus β-Keto-acyl carrier protein reductase promoter for regulatory cis-acting elements". Thesis, Durham University, 2002. http://etheses.dur.ac.uk/4024/.

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Major interest has focused on the identification of regulatory factors involved in lipid biosynthesis. This study examined the B.napus β-Keto-ACP reductase 5' sequence for potential regulatory cis-acting elements. The 5' sequence of the most highly expressed Brassica napus β-Keto-ACP reductase isoform was fused to the reporter gene β-glucuronidase (GUS) and its expression pattern examined within transgenic Arabidopsis. The construct was shown to act as a functional promoter and direct transcription within embryos, cotyledons and roots. There was no apparent staining within the true leaves, but

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33

Schmitzberger, Florian Johannes. "Structural studies of two enzymes of pantothenate biosynthesis in Escherichia Coli." Thesis, University of Cambridge, 2004. https://www.repository.cam.ac.uk/handle/1810/264125.

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Pantothenate (vitamin B5), which is the invariable metabolic precursor to coenzyme A, is synthesized from L-aspartate and alpha-ketoisovalerate in a converging four-step process in bacteria. Here, structural studies of two enzymes of pantothenate biosynthesis in Escherichia coli, L-aspartate-alpha-decarboxylase and ketopantoate hydroxymethyltransferase, are described. Ketopantoate hydroxymethyltransferase catalyzes the transfer of a hydroxymethyl group on to alpha-ketoisovalerate, assisted by the cofactor 5,10-methylene-5,6,7,8-tetrahydrofolate. In order to determine the mode of cofactor bindi

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34

Dilling, Bradley Paul. "Mapping and phenotypic characterization of temperature sensitive vaccinia virus mutants cts6 and cts9." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004844.

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Thesis (M.S.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 51 pages. Includes Vita. Includes bibliographical references.

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35

Mellor, Sarah Louise. "Development of novel solid-phase chemistry and building blocks for the synthesis of antimicrobial peptides." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243473.

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36

Jiang, Ming. "Elucidation of menaquinone biosynthesis in escherichia coli and explorative investigation of protein organization in the pathway /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202008%20JIANG.

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37

Rajangam, Alex Selvanayagam. "Discovery and Characterization of a Novel Microtubule Associated Protein Involved in Cellulose Biosynthesis." Doctoral thesis, Stockholm : School of Biotechnology, Royal Institute of Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4812.

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38

Revill, W. Peter. "The role of acyl carrier protein in fatty acid biosynthesis in Saccharopolyspora erythraea." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239656.

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39

Corbett, Mary Campbell. "Investigation of the structure and biosynthesis of the nitrogenase molybdenum-iron protein metalloclusters /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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40

Ishikawa, Yoshihiro. "A molecular chaperone complex as a protein folding machine involved in collagen biosynthesis." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120704.

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41

Burgess, Treena. "Changes in protein biosynthesis associated with the development of Pisolithus-Eucalyptus grandis ectomycorrhizas." Thesis, Burgess, Treena ORCID: 0000-0002-7962-219X (1995) Changes in protein biosynthesis associated with the development of Pisolithus-Eucalyptus grandis ectomycorrhizas. PhD thesis, Murdoch University, 1995. https://researchrepository.murdoch.edu.au/id/eprint/25142/.

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Ectomycorrhizas are formed as the outcome of a symbiotic association between the fine roots of the majority of temperate forest tree species and numerous species of higher order fungi. The development of an ectomycorrhizal structure involves the attraction of the fungal symbiont to the root surface, its recognition and attachment, the subsequent proliferation of the hyphre on the root surface and the formation of the Hartig net between root cells. Ectomycorrhizal formation is a complex and dynamic process during which the morphology, physiology and biochemistry of the individual symbionts alte

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42

Jiang, Ying. "Transfer of the Ribosome-Nascent Chain Complex to the Translocon in Cotranslational Translocation: A Thesis." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/332.

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Cotranslational translocation is initiated by targeting of a ribosome-bound nascent polypeptide chain (RNC) to the endoplasmic reticulum (ER) membrane. The targeting reaction is coordinated by the signal recognition particle (SRP) through its interaction with the RNC and the membrane-bound SRP receptor (SR). A vacant translocon is a prerequisite for the subsequent nascent chain release from SRP-SR-RNC complex. It has been proposed that the protease-accessible cytosolic domains of the Sec61p complex play an important role in posttargeting steps by providing the binding site for the ribosome or

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43

Jia, Mo, Hao Wu, Kasi Clay, Rudolf Jung, Brian Larkins, and Bryan Gibbon. "Identification and characterization of lysine-rich proteins and starch biosynthesis genes in the opaque2 mutant by transcriptional and proteomic analysis." BioMed Central, 2013. http://hdl.handle.net/10150/610085.

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BACKGROUND:The opaque2 mutant is valuable for producing maize varieties with enhanced nutritional value. However, the exact mechanisms by which it improves protein quality and creates a soft endosperm texture are unclear. Given the importance of improving nutritional quality in grain crops, a better understanding of the physiological basis for these traits is necessary.RESULTS:In this study, we combined transcript profiling and proteomic analysis to better understand which genes and proteins are altered by opaque2 in the W64A inbred line. These analyses showed that the accumulation of some lys

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44

Deutsch, Christopher Wayne. "Discovery and Characterization of the Proteins Involved in the Synthesis of N⁶-Threonylcarbamoyl Adenosine, a Nucleoside Modification of tRNA." PDXScholar, 2016. http://pdxscholar.library.pdx.edu/open_access_etds/3080.

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N6-threonylcarbamoyl adenosine (t6A) is a universally conserved tRNA modification found at position 37 of tRNAs which decode ANN codons. Structural studies have implicated its presence as a requirement for the disruption of a U-turn motif in certain tRNAs, leading to the formation of properly structured anticodon stem loop. This structure is proposed to enhance the base pairing between U36 of tRNA and A1 of the codon which aids in translational frame maintenance. Despite significant effort since its discovery in the 1970s the enzymes involved in its biosynthesis remained undiscovered. Bioinfor

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45

Fajardo, Mark A. "Defining cis- and trans-acting components for Prm-1 temporal translational control during murine spermatogenesis /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/10251.

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46

Pierzchalski, Keely A. "Impact of Cellular Retinol Binding Protein, Type I on Retinoic Acid Biosynthesis and Homeostasis." Thesis, University of Maryland, Baltimore, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3704610.

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<p> <b>Statement:</b> A global <i>Rbp1</i> knock out (<i> Rbp1-/-</i>) mouse model was used to correlate direct retinoid measurements with vitamin A metabolizing and atRA biosynthesizing enzyme activities, Crbp function and tissue microenvironment for the first time. </p><p> <b>Methods:</b> atRA was quantified by LC-MRM<sup>3</sup> and ROL/RE/RAL was quantified by HPLC-UV. Enzyme activities were measured from enzymes present in subcellular fractions isolated from WT and <i>Rbp1-/- </i> tissues. Mouse CrbpI and CrbpIII were purified from transformed <i> Escherichia coli</i> for functional co

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47

Weise, A. "Structural investigations of intrinsically disordered polypeptides : biosynthesis on the ribosome and protein misfolding disease." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1472901/.

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Intrinsically disordered proteins constitute a significant proportion of our proteome and are emerging targets of modern structural and molecular biology through their involvement in a range of functions crucial for the survival of the cell. Their malfunction and aggregation is known in many cases to lead to devastating pathologies including Parkinson’s disease (α-synuclein, αSyn) and amyloid lateral sclerosis (TAR DNA- binding protein, TDP-43). NMR spectroscopy, is a high resolution structural technique that is especially well suited to provide residue-specific information on flexible and uns

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48

Webb, Thomas Robert. "A mutation in a mouse J-protein that functions in the diphthamide biosynthesis pathway." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/29417.

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Chromosomal deletions can be used in mutagenesis strategies that screen for recessive phenotypes. Several mouse chromosomal deletions are available which remove the Pax6 gene and result in the small-eye phenotype. Deletion of the syntenic region in humans results in the phenotypically variable WAGR syndrome. The Pax6Sey~1H deletion spans 3 Mb and includes 15 genes. This deletion has been used in an ENU mutagenesis screen for phenotypes revealed when hemizygous with the deletion. One such mutation, which is lethal against the Pax6Sey~1H deletion, has been found from 233 pedigrees. Mice heterozy

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49

Cross, Benedict C. S. "The biosynthesis and membrane integration of P2X₂ at the endoplasmic reticulum." Thesis, University of Manchester, 2008. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:77482.

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A crucial step in the biosynthesis of membrane proteins is their incorporation into the hydrophobic environment of the lipid bilayer. In eukaryotic cells this event occurs largely in concert with translation on ribosomes bound to the membrane of the endoplasmic reticulum (ER) at a site termed the ER translocon. This dynamic proteinaceous complex forms an aqueous conduit across the ER membrane and is laterally gated to allow transmembrane (TM) segments to partition into the lipid phase. In the case of polytopic membrane proteins, the coordinated release of multiple TM segments by the ER translo

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50

Rofougaran, Reza. "DNA precursor biosynthesis-allosteric regulation and medical applications." Doctoral thesis, Umeå : Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1678.

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