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Dissertations / Theses on the topic 'Protein-DNA Complexes'

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Published: 4 June 2021

Last updated: 7 September 2023

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1

DiCapua, Elisabeth. "Complexes of recA protein with DNA /." [S.l.] : [s.n.], 1986. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8212.

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2

Hammond, Maria. "DNA-Mediated Detection and Profiling of Protein Complexes." Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204861.

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Proteins are the effector molecules of life. They are encoded in DNA that is inherited from generation to generation, but most cellular functions are executed by proteins. Proteins rarely act on their own – most actions are carried out through an interplay of tens of proteins and other biomolecules. Here I describe how synthetic DNA can be used to study proteins and protein complexes. Variants of proximity ligation assays (PLA) are used to generate DNA reporter molecules upon proximal binding by pairs of DNA oligonucleotide-modified affinity reagents. In Paper I, a robust protocol was set up f

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3

Berge, Torunn. "Structural analysis of DNA and DNA-protein complexes using atomic force microscopy." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621339.

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4

Preston, Nicola Susan. "Structure and DNA binding of HMG boxes." Thesis, University of Portsmouth, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310386.

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5

Luo, Dan. "Novel crosslinking technologies to assess protein-DNA binding and DNA-DNA complexes for gene delivery and expression." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1114436532.

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6

Luo, Dan. "Novel crosslinking technologies to assess protein-DNA binding and DNA-DNA complexes for gene delivery and expression /." Connect to resource, 1998. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1114436532.

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7

Bielskienė, Kristina. "Analysis of the barley (Hordeum vulgare) tightly bound DNA-protein complexes." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20091202_111955-77123.

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Despite a great deal of research, the functional significance of tightly bound DNA-protein complexes is not yet clear, therefore these complexes are perfect object for pioneering research. Very little is known about plant TBP-DNA complexes. In this work we investigated barley TBP-DNA complexes from different organs (first leaves, roots and coleoptiles) at different developmental stages. We characterized individual components of tightly bound DNA-proteins complexes: polypeptides (TBP) and DNA. We isolated and characterized TBP proteins from barley first leaves, roots and coleoptiles of differen

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8

Luo, Dan. "Novel cross-linking technologies to assess protein-DNA binding and DNA-DNA complexes for gene delivery and expression /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487946776022443.

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9

Fischhaber, Paula L. "Investigations at the molecular interfaces of complexes formed by the proteins ADR1 and xUBF1 with DNA /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8648.

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10

Yan, Junhong. "DNA-Assisted Immunoassays for High-Performance Protein Analyses." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236591.

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Proteins play important roles in most cellular functions, such as, replication, transcription regulation, signal transduction, for catalyzing chemical reaction, etc. Technologies developed to identify proteins rely either on observing their own properties such as charge, size, mass to charge ratio or sequence composition; or on using affinity reagents that recognize specific protein targets. Immunoassays utilizing functionalized affinity reagents are powerful for targeted proteomics. Among them, DNA-assisted immunoassays in which affinity reagents are labeled with DNA molecules, offer some uni

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11

Toma, Adriana Cristina. "DNA condensation by a basic protein, the salmon protamine." Paris 11, 2008. http://www.theses.fr/2008PA114828.

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In vivo les protamines condensent l'ADN dans la tête des spermatozoïdes, mais le mécanisme impliqué n'est pas complètement compris. Nous avons étudié la condensation de l'ADN par des protamines de saumon in vitro en utilisant différentes approches expérimentales. Les transitions d'états, la solubilité de ces complexes et la densité des précipités sont trouvés dépendants des concentrations ioniques<br>In vivo protamine condense DNA in the sperm head but the mechanism of this process is not completely understood. We examine the efficiency of salmon protamine to condense DNA in vitro using differ

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12

Gilljam, Karin Margaretha. "DNA repair protein complexes, functionality and significance for repair efficiency and cell survival." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kreftforskning og molekylær medisin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-12246.

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DNA‐reparasjons‐protein‐komplekser, funksjonalitet og signifikans for reparasjonseffektivitet og skadetoleranse All informasjon om en organisme er lagret i vår arvestoff, DNA. DNA er et relativt ustabilt makromolekyl som konstant blir utsatt for farer som truer dets integritet, både fra omgivelsene og fra kjemiske prosesser inne i selve cellen. I tillegg kan baser spontant bli mistet uten noe form for påvirkning. Selve kopieringen av DNA, den såkalte DNA-replikasjonen er svært rask og er en kritisk prosess i cellen hvor mye kan gå galt. I tillegg kan ureparerte DNA-skader ved replikasjonen for

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13

Tomãs, de Oliveira Isabel. "Packing and distribution of empty space in liquids, proteins and protein-DNA complexes." Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211651.

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14

Saurabh, Suman. "Nature of Inter-biomolecular interaction and its consequences : protein, DNA and their Complexes." Thesis, Tours, 2017. http://www.theses.fr/2017TOUR4052/document.

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Le monde biologique est rempli de mystères. La compréhension de nombreux processus biologiques extrêmement complexes est grandement améliorée par la combinaison d’approches empruntées à différentes disciplines telles que la chimie et plus récemment la physique. La physique utilise des outils expérimentaux tels que les pinces optiques et les microscopies optique et électronique pour explorer les mécanismes à l’échelle microscopique se déroulant dans la cellule. La connaissance de la nature des interactions entre biomolécules et la possibilité de traduire ces interactions en équations ont permis

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15

Kim, Soojeong. "A 4-string tangle analysis of DNA-protein complexes based on difference topology." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/528.

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An n-string tangle is a three dimensional ball with n-strings properly embedded in it. In late the 80's, C. Ernst and D. Sumners introduced a tangle model of protein-DNA complexes. This model assumes that the protein is a 3-dimensional ball and the protein-bound DNA are strings embedded inside the ball. Originally the tangle model was applied to proteins such as Cre recombinate which binds two DNA segments. The protein breaks and rejoins the DNA segments and then creatss knotted DNA. When this kind of protein complex bounds circular DNA, there will be two DNA loops outside of the DNA-protein c

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16

RINALDI, CARLO. "Functions and regulation of the MRX and Ku protein complexes at DNA ends." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/402372.

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L'instabilità del genoma è una delle caratteristiche delle cellule tumorali e può essere causata da difetti nella riparazione del DNA. In particolare, le rotture del doppio filamento del DNA (DSBs) sono lesioni altamente citotossiche che possono formarsi accidentalmente durante la replicazione del DNA o in seguito all'esposizione ad agenti genotossici, e devono essere correttamente riparate al fine di garantire la stabilità genomica. Per far fronte a queste lesioni del DNA, le cellule eucariotiche attivano la risposta al danno del DNA (DDR) e utilizzano due meccanismi principali per la riparaz

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17

Watkins, Jason Derrick. "X-ray structures of P22 c2 repressor-DNA complexes the mechansism of direct and indirect readout /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26709.

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Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Loren D. Williams; Committee Member: Donald Doyle; Committee Member: Nicholas V. Hud; Committee Member: Roger Wartell; Committee Member: Stephen Harvey. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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18

Fischer, Nina M. [Verfasser], and Oliver [Akademischer Betreuer] Kohlbacher. "Modeling Flexibility of Protein-DNA and Protein-Ligand Complexes using Molecular Dynamics / Nina M. Fischer ; Betreuer: Oliver Kohlbacher." Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1162896728/34.

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19

Kolli, Ramya. "Effect of Leaving Ligands of Platinum(II) Diamine Complexes on DNA and Protein Residues." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1268.

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Platinum compounds are widely used drugs in cancer treatments. Although DNA is the biological target, reaction of platinum compounds with proteins is also potentially significant. Our objective is to study the effects of leaving ligands on the relative reactivity between 5'-GMP (guanosine 5' phosphate), a key DNA target, and N-Acetyl - L-Methionine (N-AcMet), a key protein target. We have used NMR spectroscopy to monitor reactions with N-AcMet and 5'-GMP added to a platinum complex to see which products are formed preferentially. Previous research showed that both a non-bulky complex such as [

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20

Davies, Emma. "High-resolution atomic force microscopy and current-voltage characterisation of DNA and protein complexes." Thesis, Swansea University, 2006. https://cronfa.swan.ac.uk/Record/cronfa42320.

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Using the technique of non-contact atomic force microscopy (NC-AFM), the structural properties of DNA and protein complexes were studied at the singlemolecule level and at high-resolution. The electrical properties of these biomolecules were then investigated using an electrode setup. This work focussed on the visualisation of DNA strands, nucleosomes, PUT3 protein and DNA-PUT3 complexes and the effect of protein on the conductivity of DNA. NC-AFM experiments were performed in vacuum and results were compared to tappingmode AFM (TM-AFM) experiments performed in air. The detailed structure of D

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21

Anderson, Robert James. "Development of an affinity partitioning method for DNA/protein complexes and its application to interactions of topoisomerase II with DNA." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386626.

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22

Ma, Xin. "MASS SPECTROMETRY DISSOCIATION STUDIES OF PROTEIN-PROTEIN AND PROTEIN-NUCLEIC ACID COMPLEXES AND 13C FLUX OF AMINO ACIDS." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397773864.

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23

Grippon, Ayse Seden. "Protein complexes in base excision repair : biochemical and kinetic analysis of mismatch uracil DNA glycosylase." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5666.

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Mismatch uracil DNA glycosylase (MUG) is an E. coli enzyme involved in the repair of ethenocytosine and uracil through the base excision repair pathway. MUG is known to bind the abasic site tightly. This may act to protect the abasic lesion, but the question then is how is the site handed over to the AP Endonuclease? Much has been made of the increase in turnover of some DNA glycosylases by AP endonucleases, but it is not clear whether this occurs via an active displacement mechanism or by passive diffusion. We are addressing these questions by studying the kinetics of MUG interactions with it

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24

Sachsenberg, Timo [Verfasser], and Oliver [Akademischer Betreuer] Kohlbacher. "Computational Methods for Mass Spectrometry-based Study of Protein-RNA or Protein-DNA Complexes and Quantitative Metaproteomics / Timo Sachsenberg ; Betreuer: Oliver Kohlbacher." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/116863430X/34.

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25

Beamish, Eric. "Precise Size Control and Noise Reduction of Solid-state Nanopores for the Detection of DNA-protein Complexes." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23569.

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Over the past decade, solid-state nanopores have emerged as a versatile tool for the detection and characterization of single molecules, showing great promise in the field of personalized medicine as diagnostic and genotyping platforms. While solid-state nanopores offer increased durability and functionality over a wider range of experimental conditions compared to their biological counterparts, reliable fabrication of low-noise solid-state nanopores remains a challenge. In this thesis, a methodology for treating nanopores using high electric fields in an automated fashion by applying short

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26

Chichetu, Karen. "Characterization, DNA Binding and Cleavage Activities of New Prodigiosin and Tambjamine Analogues and Their Cu²⁺ and Zn²⁺ Complexes." PDXScholar, 2015. http://pdxscholar.library.pdx.edu/open_access_etds/2467.

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Prodigiosins and tambjamines are natural compounds from bacterial and marine sources belonging to a family containing a common 4-methoxy-2,2'-bipyrrole core. These compounds have received a lot of interest due to their promising biological activities. Studies have suggested DNA as a potential therapeutic target for the natural prodigiosin and tambjamine due to their ability to facilitate oxidative DNA cleavage in the presence of Cu2+. Based on this we sought to study the metal binding activity of new prodigiosin and tambjamine analogues. A new prodigiosin analogue was synthesized and complexed

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27

Shajani, Zahra. "Characterizing internal dynamics in nucleic acids by nuclear magnetic resonance spectroscopy : a study of RNA, DNA, and RNA-protein complexes /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8587.

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28

Nguyen, Huynh Nha Thi. "Développements en spectrométrie de masse pour l’étude des complexes biologiques." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF045/document.

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L’élucidation des interactions non-covalentes des complexes biologiques revêt d’une importance majeure dans la compréhension du fonctionnement cellulaire. L’objectif de ce travail de thèse est d’approfondir les développements de la spectrométrie de masse (MS) pour l’étude de ces complexes, que ce soit par MALDI-MS (la désorption-ionisation laser assistée par matrice) ou par ESI-MS (l’ionisation électrospray). Ce travail s’est articulé autour de trois axes : i) étude de la stœchiométrie et de la topologie du complexe SAGA HAT (Spt-Ada-Gcn5 Acétyltransferase, module Histone Acétyl Transferase) p

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29

Quebre, Valentin. "Etude des complexes ADN-protéines impliqués dans la ségrégation de l'ADN bactérien." Thesis, Toulouse 3, 2022. http://www.theses.fr/2022TOU30072.

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La ségrégation des chromosomes et des plasmides à bas nombre de copies chez les bactéries est basée sur un mécanisme actif de positionnement. Il repose sur des systèmes de partition qui assurent la répartition intracellulaire des réplicons afin qu'ils soient transmis de façon fidèle à la descendance. Ils font intervenir trois partenaires encodés par la molécule à ségréger. Une protéine de liaison à l'ADN (ParB) s'assemble en un complexe de partition autour d'une séquence centromérique (parS). Une protéine NTPase, interagissant avec le complexe de partition, est responsable de l'activité de ség

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30

Padilla, Roberto. "Discovering the Potential of Photoluminescent Ruthenium(II) Complexes as Photodynamic Therapy Agents." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/78190.

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Anthracene was attached to light activated, ruthenium-based DNA disruptors to probe their distribution in cancer cells. The objective of this research is to understand the photophysical properties (Chapter 2), photoreactivity toward DNA and proteins (Chapter 3), and localization within cancer cells (Chapter 4) of ruthenium complexes that demonstrate promise as photodynamic therapy (PDT) agents. [(AnthbpyMe)(bpy)Ru(dpp)]2+ (1) and [(AnthbpyMe)2Ru(dpp)]2+ (2) absorb visible light with metal-to-ligand charge transfer (MLCT) transitions at 459 nm (16,000 M-1 cm-1 ) and 461 nm (21,000 M-1 cm-1 ),

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31

Stadler, Jens Michael [Verfasser]. "XPF-ERCC1 protein complexes regulate 5´ DNA incision and XPC deubiquitylation in the Global Genome branch of Nucleotide Excision Repair / Jens Michael Stadler." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1188428802/34.

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32

Taylor, James Edward Nathan. "Biochemical and biophysical characterisation of the genetically engineered Type I restriction-modification system, EcoR124I NT." Thesis, University of Portsmouth, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424193.

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The EcoR124INT restriction-modification (R-M) system contains the genes HsdS3, HsdM and HsdR. S3 encodes the N-terminal domain of the wild-type S subunit and has been shown to dimerise in solution (Smith et al., 1998). Following purification of the subunits of the EcoR124INT R-M system, complexes of the methyltransferase S3/M and restriction endonuclease S3/M/R were formed and shown to have activity in vitro, methylating and hydrolysing a symmetrical DNA recognition sequence, respectively. The DNA mimic OCR (overcome classical restriction) protein inhibited the methyltransferase activity in vi

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33

Ricci, Antonio. "Synthesis and characterization of natural compounds derivatives for biological systems analysis: Topoisomerase I-DNA-camptothecin and protein kinase A-cyclic AMP complexes as case studies." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3427352.

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The aim of the present work lies in the analylis of two biological important enzymes: Human TopoisomeraseI and Protein Kinase A. Human Topoisomerase I (Topo I) is one of the enzyme involved into the control of the replication of the cell through the management of the topology of DNA, in particular the DNA supercoiling. Top1 relaxs supercoiled DNA operating a break in only one strand of the DNA duplex; it plays a fundamental step in the replicative process of the cell. Due to its crucial role, great efforts were made to obtain inhibitors of this enzime in order to obtain potential anticancer

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34

Heessen, Stijn. "Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-600-6/.

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35

Xu, Guozhou. "Crystal structures of the Fanconi anemia proteins : structure of the interstrand cross-linking repair protein Fanconi anemia protein I (FANCI); structure of the human FANCF C-terminal domain; reconstitution and crystallilzation of the sub-complexes in the Fanconi anemia core complex /." Access full-text from WCMC, 2009. http://proquest.umi.com/pqdweb?did=1692100351&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Bielskienė, Kristina. "Miežių (Hordeum vulgare) tvirtų DNR-baltymų kompleksų tyrimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20091202_112036-51456.

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Žinoma, kad pastovi nehistoninių polipetidų frakcija yra išgryninama kartu su eukariotine DNR ir sudaro labai tvirtus (galbūt kovalentinius) kompleksus tarp branduolio baltymų ir DNR. Nustatyta, kad Erlicho ascito tvirtuose DNR-baltymų kompleksuose yra baltymas C1D, baltymai, pasižymintys fosfataziniu ir kinaziniu aktyvumais, kai kurie proteazių slopikliai ir kiti, dar neištirti baltymai. Nepaisant intensyvių tyrinėjimų, eukariotinių ląstelių tvirti DNR-baltymų kompleksai vis dar lieka menkai aprašyti ir yra objektas tolimesniems tyrimams. Augalų TBP-DNR kompleksai kol kas buvo tyrinėti labai

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Oikonomopoulos, Spyridon. "Inferring structural properties of protein-DNA binding using high-throughput sequencing : the paradigm of GATA1, KLF1 and their complexes GATA1/FOG1 and GATA1/KLF1 : insights into the transcriptional regulation of the erythroid cell lineage." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:72b92906-4ef6-4c1d-9155-484521027e2e.

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GATA1 and KLF1 are transcription factors that regulate genes which are important for the development of erythroid cells. The GATA1 transcriptional co-factor FOG1 has been shown to be essential in a wide range of GATA1 dependent cellular functions. Here we tried to understand the diverse mechanisms by which GATA1 and KLF1 recognize their binding sites, how the GATA1 recognition mechanisms are affected by complexation with either FOG1 or KLF1 and how the GATA1 recognition mechanisms affect the transcriptional regulation of the erythroid differentiation. We profiled the DNA binding specificities/

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Wang, Yanfei. "Fuzzy methods for analysis of microarrays and networks." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/48175/1/Yanfei_Wang_Thesis.pdf.

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Bioinformatics involves analyses of biological data such as DNA sequences, microarrays and protein-protein interaction (PPI) networks. Its two main objectives are the identification of genes or proteins and the prediction of their functions. Biological data often contain uncertain and imprecise information. Fuzzy theory provides useful tools to deal with this type of information, hence has played an important role in analyses of biological data. In this thesis, we aim to develop some new fuzzy techniques and apply them on DNA microarrays and PPI networks. We will focus on three problems: (1) c

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De, Moura Miguez Araujo Sofia Jorge. "Interactions and function of nucleotide excision repair protein complexes." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322320.

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Éthève, Loic. "Étude de l’assemblage, de la mécanique et de la dynamique des complexes ADN-protéine impliquant le développement d’un modèle « gros grains »." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1242/document.

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Les interactions ADN-protéine sont fondamentales dans de nombreux processus biologiques tels que la régulation des gènes et la réparation de l'ADN. Cette thèse est centrée sur l'analyse des propriétés physiques et dynamiques des interfaces ADN-protéine. À partir de l'étude de quatre complexes ADN-protéine, nous avons montré que l'interface ADN-protéine est dynamique et que les ponts salins et liaisons hydrogène se forment et se rompent dans une échelle de temps de l'ordre de la centaine de picosecondes. L'oscillation des chaînes latérales des résidus est dans certains cas capable de moduler la

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41

Siu, Kit-man Phyllis. "Luminescent cyclometalated platinum(II) complexes : protein binding studies and biological applications /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B30575357.

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Siu, Kit-man Phyllis, and 蕭潔敏. "Luminescent cyclometalated platinum(II) complexes: protein binding studies and biological applications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B4501498X.

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Nassar, Joelle. "Caractérisation de la fonction de OBI1, une E3 ubiquitine ligase, dans la réplication de l'ADN." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT039.

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La division cellulaire est l’un des processus cellulaires les plus complexes. Pour que cette division se déroule correctement, la cellule doit répliquer de manière fiable l’intégralité de son génome. Durant ce processus, la réplication de l’ADN est initiée a des sites prédéfinis du génome, appelés « origines de réplication ». Vu qu’un dysfonctionnement de l'activité des origines est lié à plusieurs pathologies humaines, leur activation doit être hautement régulée. Plusieurs protéines ont été trouvées aux origines de la réplication, mais aucune n’explique comment ces origines sont reconnues et

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Foos, Nicolas. "Etudes structurales d'un complexe HOX-PBC de drosophile. : Un exemple de régulateur transcriptionnel." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4075.

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Les protéines Hox sont des protéines à homéodomaine. Elles sont très conservées et impliquées dans l'identité cellulaire selon les axes antéropostérieur, dorsoventral et proximodistal. Elles reconnaissent l'ADN pour réguler l’expression des gènes. La coopérativité avec des partenaires de la famille PBC est un modèle pour l'amélioration de la spécificité. Cette étude utilise Ubx (Hox) et Exd (PBC) de D. melanogaster comme modèles. Deux modes d'interaction entre Ubx et Exd : un par le motif « hexapeptide » d'Ubx et un autre par le motif UbdA objet de ce travail. UbdA se situe en C-terminal de l'

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Marchetti, Laura. "Dynamics and interactions of an oncogenic homeotic protein within human replicative complexes." Doctoral thesis, Scuola Normale Superiore, 2010. http://hdl.handle.net/11384/85944.

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The regulation of human DNA replication operates via the time-programmed activation and deactivation of approximately 30,000 replication origins distributed along the genome. A multi-protein replicative complex recognizes and assembles onto each origin; this determines the local unwinding of the origin DNA and the start of two oppositely moving replicative forks. The mechanism that governs the selection of a specific DNA sequence as human (and, more generally, metazoan) origin, in the course of G1 phase of the cell-cycle, is still poorly understood. The lack of DNA-sequence consensus amon

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ROBISON, JACOB. "INTERACTION OF THE Mre11/Rad50/Nbs1 (MRN) COMPLEX AND REPLICATION PROTEIN A (RPA) IN RESPONSE TO DNA DAMAGE." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1112971385.

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Ashton, Nicholas W. "Characterisation of human single-stranded DNA-binding protein 1 (hSSB1) regulation by post-translational modifications." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/98660/1/Nicholas_Ashton_Thesis.pdf.

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Human single-stranded DNA-binding protein 1 (hSSB1) is required for the timely repair of double-strand DNA breaks, as well as the stabilisation and restart of stalled replication forks. In this work, evidence is provided that cellular survival in response to replication stress is promoted by dynamic phosphorylation of hSSB1 by the DNA-dependent protein kinase (DNA-PK) and PPP-family protein phosphatases. These data provide insight into the functional regulation of hSSB1 following replication fork disruption.

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Hogrel, Gaëlle. "Interactions entre composants de la maintenance génomique chez Archaea hyperthermophiles : étude des associations entre PCNA et le complexe Mre11-Rad50 et entre les hélicases MCM et XPD." Thesis, Brest, 2015. http://www.theses.fr/2015BRES0082/document.

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Vivant à des températures supérieures à 80°C, les archées hyperthermophiles ont démontré une capacité étonnante à se remettre de dommages dans leur ADN, suggérant la présence de gardiens du génome particulièrement efficaces. Ces gardiens, des protéines relativement similaires entre archées et eucaryotes, agissent et interagissent dans un ballet savamment orchestré par la cellule. Chez les archées, plusieurs protéines impliquées dans des voies essentielles à la réparation de I'ADN manquent à I'appel. Précédemment au laboratoire un réseau impliquant les protéines de la maintenance génomique de P

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Zabolotnaya, Ekaterina. "DNA double-strand break repair studied by atomic force microscopy." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275890.

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DNA double-strand breaks (DSBs), where both strands of the DNA duplex are simultaneously fractured, are considered the most lethal type of DNA damage. The conserved Mre11-Rad50 DNA repair complex enables the catalytic activities of the Mre11 nuclease and the Rad50 ATPase to function together to coordinate the recognition and processing of DSBs prior to the recruitment of long-range end-resection machinery required to trigger the DSB repair by the homologous recombination (HR) pathway. Fast-scan atomic force microscopy (AFM) in fluid conditions was primarily used to explore the architectural ar

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Camacho, Inês Sofia Cortes Eusébio. "Effects of UV radiation exposure on DNA and DNA repair enzymes." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8263.

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Dissertação para obtenção do Grau de Mestre em Biotecnologia<br>DNA integrity in the cell is under constant threat from damaging agents of endogenous or exogenous origin, such as UV light, ionizing radiation and oxidative stress. Although the effects of these carcinogens on DNA have been extensively studied, very little is known about their effect on DNA repair enzymes. The aim of the present work was the study of the effect of UV radiation on E. coli Endonuclease III, a DNA glycosylase belonging to base excision repair system. This enzyme was homologously overexpressed and then purified wi

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