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Dissertations / Theses on the topic 'Protein dynamic'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Munz, Marton. "Computational studies of protein dynamics and dynamic similarity." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:2fb76765-3e43-409b-aad3-b5202f4668b3.

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At the time of writing this thesis, the complete genomes of more than 180 organisms have been sequenced and more than 80000 biological macromolecular structures are available in the Protein Data Bank (PDB). While the number of sequenced genomes and solved three-dimensional structures are rapidly increasing, the functional annotation of protein sequences and structures is a much slower process, mostly because the experimental de-termination of protein function is expensive and time-consuming. A major class of in silico methods used for protein function prediction aim to transfer annotations bet

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2

Wallach, Thomas. "A dynamic circadian protein-protein interaction network." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16604.

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Die dynamische Regulation von Protein-Protein Interaktionen (PPIs) ist wichtig für den Ablauf von biologischen Prozessen. Die circadiane Uhr, die einen ~24 Stunden Rhythmus generiert und eine Vielzahl von physiologischen Parametern steuert kann auch die Dynamik von PPIs regulieren. Um neue Erkenntnisse über regulatorische Mechanismen innerhalb des molekularen Oszillators zu gewinnen, habe ich zunächst alle möglichen PPIs zwischen 46 circadianen Komponenten mittels eines systematischen yeast-two-hybid (Y2H) Screens bestimmt. Dabei habe ich 109 bis dahin noch unbekannte PPIs identifiziert und

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3

Bhat, Venugopal T. "Protein-directed dynamic combinatorial chemistry." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/8758.

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Dynamic combinatorial chemistry (DCC) is a novel approach to medicinal chemistry which integrates the synthesis and screening of small molecule libraries into a single step. The concept uses reversible chemical reactions to present a dynamic library of candidate structures to a template which selects and removes the best binder from equilibrium. Using this evolutionary process with a biopolymer template, such as a protein, leads to the protein directing the synthesis of its own best ligand. Biological DCC applications are extremely challenging since the thermodynamic criterion of reversibility

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4

Gallia, Jason. "Protein identification by dynamic programming." Diss., Online access via UMI:, 2009.

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5

Jochi, Yasumasa. "Crystallographic Refinement of Protein Dynamic Structure." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150011.

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6

Rose, Alexander. "The dynamic coupling interface of G-protein coupled receptors." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17215.

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Um mit ihrer Umgebung zu kommunizieren verfügen lebende Zellen über Rezeptoren, welche die umschließende Membran überbrücken. Die vorherrschende G-Protein-gekoppelte Rezeptoren (GPCR) erhalten Informationen von Außerhalb durch Bindung eines Liganden, wodurch der Rezeptor aktiviert wird. Während der Aktivierung bildet sich innerzellulär ein offener Spalt, in den ein G-Protein (Gαβγ, G) mit seinem C-terminalen Ende koppeln kann. Die Bindung an einen GPCR führt in der Gα-Untereinheit vom Gαβγ zu einen GDP/GTP-Austausch, welcher für die weitere Signalübertragung ins Zellinnere notwendig ist. Die K

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7

Beveridge, Rebecca. "Mass spectrometry methods for characterising the dynamic behaviour of proteins and protein complexes." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/mass-spectrometry-methods-for-characterising-the-dynamic-behaviour-of-proteins-and-protein-complexes(81961313-2d3e-4ad3-9c6f-6299549e9738).html.

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Research into the relationship between the structure and function of proteins has been ongoing now for several decades. More recently, there has been an explosion in the investigation of the dynamic properties of proteins, and how their dynamic propensity relates to their function. This new direction in protein research requires new techniques to analyse protein dynamics, since most traditional techniques are biased towards a fixed tertiary structure. Mass spectrometry (MS) is emerging as a powerful tool to probe protein dynamics since it can provide information on interconverting conformation

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8

Lock, John George. "Dynamic imaging of post-Golgi protein transport /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19397.pdf.

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9

Reeh, Philipp. "Dynamic Multivalency For The Recognition Of Protein Surfaces." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/283236.

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En esta tesis doctoral el concepto de multivalencia en el reconocimiento de proteínas (lectinas) con azúcares se combinó con la idea de la química dinámica combinatoria. Esto se aplicó, no sólo para sacar ventaja del efecto de la mejor afinidad de tales sistemas multivalentes, sino también para dotar al sistema con una mayor variedad de constituciones y geometrías. La determinación de las afinidades relativas de los miembros de la biblioteca dinámica dio una visión de los requisitos necesarios para la unión entre azúcares – lectina. El primer enfoque para acceder a los sistemas multivalent

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10

Carter, Nathan Andrew. "Design Strategies for Dynamic Self-assembled Protein Materials." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/93207.

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Structures in nature exhibit unique and complex architectures whose order propagates from nano- (10-9 m) to macro-scales (mm to m). These structures give rise to a rich diversity of adaptive function that allows for life in all environments on Earth. This complex functionality has driven research into bio-inspired materials where scientists investigate the complex relationship between sequence, structure and function of these materials. A good illustrative example of the effect that hierarchical structure can have is a brick wall. Bricks are laid so that the layer on top is shifted in either d

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11

Khodadadi, Sheila. "Influence of Solvent on Protein Dynamics and Activity." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1247697577.

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12

Riedmann, Caitlyn M. "THE DYNAMIC NATURE OF CHROMATIN." UKnowledge, 2017. http://uknowledge.uky.edu/biochem_etds/31.

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Eukaryotic organisms contain their entire genome in the nucleus of their cells. In order to fit within the nucleus, genomic DNA wraps into nucleosomes, the basic, repeating unit of chromatin. Nucleosomes wrap around each other to form higher order chromatin structures. Here we study many factors that affect, or are effected by, chromatin structure including: (1) how low-dose inorganic arsenic (iAs) changes chromatin structures and their relation to global transcription and splicing patterns, and (2) how chromatin architectural proteins (CAPs) bind to and change nucleosome dynamics and DNA targ

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13

Joseph, Chitra. "Secreted protein, acidic, cysteine-rich protein : a dynamic role in regulating bovine ovarian function." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546228.

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14

Taylor, Daniel. "Classification of protein domain movements using dynamic contact graphs." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/53442/.

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Protein domain movements are of critical importance for understanding macromolecular function, but little is understood about how they are controlled, their energetics, and how to characterize them into meaningful descriptions for the purpose of understanding their relation to function. Here we have developed new methods for this purpose based on changes in residue contacts between domains. The main tool used is the “Dynamic Contact Graph” which in one static graph depicts changes in contacts between residues from the domains. The power of this method is twofold: first the graphs allow one to

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15

Lee, Soojin. "Structure and dynamics in proteins Part I. Structural origins of specific DNA recognition by GFI-1 ; Part II. Structural and dynamic studies of [gamma]S-crystallin and OPJ, implications for cataract formation /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189025356.

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16

Berry, Richard M. "Possible dynamic roles for the electrostatic force in biological membrane systems." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316866.

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17

Choi, Ucheor B. "Single molecule fluorescence reveals dynamic structures of SNARE protein assemblies." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-07092009-120330/.

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Conformational information about proteins can often reveal the mechanisms of their biological functions. This thesis examines conformational aspects of the synaptic SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein complex that is essential for membrane fusion leading to Ca2+ triggered neurotransmitter release. Biochemical and high-resolution structural studies of SNARE proteins and several different assemblies of these proteins have provided a foundation for our understanding of neurotransmitter release, but the exact mechanisms these protein machines use

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18

Wong, Samuel Wing Kwong. "Statistical Computation for Problems in Dynamic Systems and Protein Folding." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11036.

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Inference for dynamic systems and conformational sampling for protein folding are two problems motivated by applied data, which pose computational challenges from a statistical perspective. Dynamic systems are often described by a set of coupled differential equations, and methods of parametric estimation for these models from noisy data can require repeatedly solving the equations numerically. Many of these models also lead to rough likelihood surfaces, which makes sampling difficult. We introduce a method for Bayesian inference on these models, using a multiple chain framework that exploi

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19

Haywood, Kieran. "The dynamic surface properties and foam stability of protein solutions." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252241.

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20

Steiert, Elena [Verfasser]. "Dynamic Protein-based Nanoparticles for Drug Delivery Applications / Elena Steiert." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1205821899/34.

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21

Wallach, Thomas [Verfasser], Hanspeter [Akademischer Betreuer] Herzel, Achim [Akademischer Betreuer] Kramer, and Martha [Akademischer Betreuer] Merrow. "A dynamic circadian protein-protein interaction network / Thomas Wallach. Gutachter: Hanspeter Herzel ; Achim Kramer ; Martha Merrow." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://d-nb.info/1027529364/34.

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22

Rubin, Jonathan. "Ion-specific and water-mediated effects on protein physical stability." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47587.

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Protein aggregation and physical stability are perpetual concerns in medicine and industry. Misfolded protein can form ordered protein aggregates, amyloids, which are associated with a host of neurodegenerative diseases in mammals and control heritable traits in fungi and yeast. Industrially, amorphous aggregates reduce the efficacy of protein-based therapeutics and activity of enzymes during production and storage. This work studies ion-specific and solvent-based effects on protein physical stability. We show that ion-specificity significantly affects amyloid formation kinetics, aggregate mor

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23

Larsson, Rikard. "Dynamic Systems for Screening, Control and Identification of Protein-Ligand Interactions." Doctoral thesis, Stockholm : Kemi, Chemistry, Kungliga Tekniska högskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4709.

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24

Poggemann, Hanna-Friederike. "Investigation on liquid liquid phase separation of lysozyme by dynamic light scattering." Thesis, Stockholms universitet, Fysikum, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193168.

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The liquid-liquid phase separation (LLPS) of biomolecules is a phenomenon which received a lot of attention in the last years because it is not only related to theformation of membraneless organelles but also to neurodegenerative diseases. Lysozyme is a globular protein that undergoes LLPS in a buffer salt system andfor that it is well investigated with several techniques like microscopy, dynamic lightscattering (DLS) or small-angle X-ray scattering. In this work we investigate the effect of temperature, solvent and sample con-centration on the diffusion coefficient, the hydrodynamic radius an

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25

Pandya, Maya Jay. "Structural and dynamic properties of a methionine-rich protein from sunflower seed." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246242.

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26

Douglas, Peter Mahan Cyr Douglas M. "The dynamic role of Hsp40 chaperones in protein aggregation and proteotoxicity." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2862.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Cell and Developmental Biology." Discipline: Cell and Developmental Biology; Department/School: Medicine.

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27

Truvé, Katarina. "Using combined methods to reveal the dynamic organization of protein networks." Thesis, University of Skövde, School of Humanities and Informatics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-962.

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<p>Proteins combine in various ways to execute different essential functions. Cellular processes are enormously complex and it is a great challenge to explain the underlying organization. Various methods have been applied in attempt to reveal the organization of the cell. Gene expression analysis uses the mRNA levels in the cell to predict which proteins are present in the cell simultaneously. This method is useful but also known to sometimes fail. Proteins that are known to be functionally related do not always show a significant correlation in gene expression. This fact might be explained by

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28

Lin, David Tse Shen. "Characterization of novel regulatory components in the dynamic protein palmitoylation cycle." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52600.

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Protein palmitoylation represents the only reversible lipid modification in the cell. As a post-translational modification, it is highly dynamic and plays an important role in protein trafficking and localization. Two families of enzymes mediate dynamic palmitoylation: palmitoyl-acyl transferases (PATs) catalyze palmitate addition, and acyl-protein thioesterases (APTs) catalyze palmitate removal. In mammalian cells, twenty-three PATs have been identified; however, the mechanisms that regulate their enzymatic activity are largely unexplored. Only two APTs, APT1 and APT2, have been identified, b

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29

Ogbuoji, Ebuka. "Protein Crystallization Methods and Apparatus." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1556924307276754.

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30

SALA, BENEDETTA MARIA. "DISSECTING STRUCTURAL ASPECTS OF PROTEIN STABILITY." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/570253.

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The contribution of a single residue in the structural stability of a whole protein can seem small if its position in the structure is not considered. Indeed, the stability of a protein is determined by the contribution of many forces among amino acids: hydrophobicity, hydrogen-bonding network and van der Waals interactions, salt bridges. Three independent projects were carried out during my PhD studies addressing mutations that affect protein fold stability. I β2-Microglobulin (β2m), the light chain of the Major Histocompatibility Class I complex (MHC-I), can assemble into amyloid fibri

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31

Heath, Emma. "Functional analysis of def-3, a novel dynamic nuclear RNA-binding protein." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408166.

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32

Mahen, Robert William John. "The role of dynamic intracellular protein mobility in mitosis and DNA repair." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610147.

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33

MELIS, RICCARDO. "Structural aspects of dynamic and DNA recognition of HPV-16 E2C protein." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/863.

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L’infezione da Papillomavirus Umano (HPV) è una delle maggiori cause eziologiche del tumore al collo dell'utero e rappresenta un grave problema di salute per le donne in tutto il mondo. La pur sperimentazione di vaccini non ha alcun effetto nel corso di infezione e il sia pur grande sforzo nella profilassi è controbilanciato dalla mancanza di accessibilità per la maggior parte della popolazione. Alla luce di queste considerazioni, non vi è la necessità di sviluppare farmaci antivirali specifici per prevenire le infezioni da HPV. Il mio lavoro di dottorato è stato incentrato sulla aspett

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34

Bertazzo, Martina <1990&gt. "Dynamic Docking, Path Analysis and Free Energy Computation in Protein-Ligand Binding." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amsdottorato.unibo.it/9290/1/TESI.pdf.

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Comprehending how drugs interact with biological macromolecules to form a complex with consequent biological response is particularly relevant in drug design to guide a rational design of new active compounds. The establishment and the duration of the protein-ligand binding complex is principally determined by thermodynamics and kinetics of the dynamical process of molecular recognition. Thus, an accurate characterization of the free-energy governing the formation of the protein-ligand complex is of fundamental importance to deeply understand each contribution to the establishment of the molec

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35

Mahon, Eugene. "Dynamic Constitutional Protein-Carbohydrate and Polyoxometalate Systems toward biomimetic sensors and membranes." Montpellier 2, 2009. http://www.theses.fr/2009MON20057.

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Le but de ce travail était d'explorer l'interaction entre les ensembles supramoléculaires constitutionnels et chimie dynamiques biomimétique et les motifs biologiques simples. La recherche a été effectuée dans les domaines d'intérêt suivants : l'interaction protéine-saccharides, les vésicules, les bicouches phospholipidiques, les canaux ioniques et le transport à travers une membrane et ont constituer trois axes de projet. Des nanoparticules ont été employée pour l'amplification de signal de fréquence d'une microbalance à cristal de quartz pour la recherche sur l'interaction de lectin-sacchari

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36

Mendes, Luis Felipe Santos. "Structural and dynamic characterization of the Golgi Reassembly and Stacking Protein (GRASP) in solution." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-18042018-094959/.

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The Golgi complex is an organelle responsible for receiving synthesized cargo from the endoplasmic reticulum for subsequent post-translations modifications, sorting and secretion. A family of proteins named Golgi Reassembly and Stacking Proteins (GRASP) is essential for the correct assembly and laterally tethering of the Golgi cisternae, a necessary structuration to keep this organelle working correctly. The GRASP structure is mainly composed of two regions: an N-terminal formed by two PDZ domains connected by a short loop (GRASP domain) and a non-conserved C-terminal region, rich in serine an

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37

Brown, Peter N. "Biophysical and structural characterisation of protein-peptide interactions." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/3982.

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Proliferating cell nuclear antigen (PCNA) is an essential protein in the cell. It is involved in transcription and many types of DNA repair and replication. Homologues of this protein are found in all orders of life. The high level of conservation and essential nature of PCNA infers that it may be a potential drug target for anti-caner drugs in humans and also a potential anti-parasitic target. X-ray structures of PCNA from Homo sapiens (Hs), Schizosaccharomyces pombe (Sp) and Leishmania major (Lm) are now available and can be used as a template for structure based drug design. In this work PC

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38

Botlani-Esfahani, Mohsen. "Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6804.

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Regulation of protein activity is essential for normal cell functionality. Many proteins are regulated allosterically, that is, with spatial gaps between stimulation and active sites. Biological stimuli that regulate proteins allosterically include, for example, ions and small molecules, post-translational modifications, and intensive state-variables like temperature and pH. These effectors can not only switch activities on-and-off, but also fine-tune activities. Understanding the underpinnings of allostery, that is, how signals are propagated between distant sites, and

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39

Dooley, Colette. "Green fluorescent protein based indicators of dynamic redox changes and reactive oxygen species." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3211820.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed June 16, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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40

Hoch-Kraft, Peter [Verfasser]. "Dynamic composition of myelin basic protein mRNA-containing ribonucleoprotein complexes / Peter Hoch-Kraft." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/1154460940/34.

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41

Abramsson, Mia. "Biophysical Characterization of Hit Compounds against a Structurally Dynamic Protein for Drug Discovery." Thesis, Uppsala universitet, Biokemi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-415678.

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42

Zhang, Wenxiang. "Optimization of protein concentration from alfalfa juice by high shear rate dynamic filtration." Thesis, Compiègne, 2016. http://www.theses.fr/2016COMP2281/document.

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Les protéines extraites des feuilles de luzerne sont une source importante de protéines. La filtration membranaire, technologie de séparation respectueuse de l’environnement avec une productivité élevée et de faible coût a été utilisée pour séparer et concentrer les protéines des feuilles de luzerne à partir de leur jus. Cependant le phénomène du colmatage de la membrane qui réduit sérieusement le flux et la séparation des protéines est un facteur limitant important dans l'application de la filtration membranaire. Pour améliorer la récupération des protéines et amenuiser le phénomène du colmat

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43

Friedrich, Kenneth Lane. "Dynamic behavior of small heat shock protein subunits and their interactions with substrates." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280410.

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Small heat shock proteins (sHsps) are oligomeric proteins expressed by cells in response to high temperatures. It is believed that sHsps are produced as a defensive mechanism against temperature stress and act as molecular chaperones by binding and protecting heat-labile proteins from irreversible aggregation. Binding results in the formation of sHsp/substrate complexes from which substrate can later be refolded by ATP-dependent chaperones. Despite past investigations, many aspects of this model remain poorly defined. Results presented here provide new insight into the mechanism of sHsp action

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44

Higgins, Colin Anthony. "Structural and dynamic determinants of inhibitor specificity among regulators of G protein signaling." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3099.

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Regulator of G Protein Signaling 4 (RGS4) mediates motor defects in Parkinson's disease. Small molecule RGS4 inhibitors (e.g. CCG-50014) modify buried cysteine residues, but the structural and dynamic mechanisms underpinning specificity of inhibitors for RGS4 within the RGS family are poorly understood. We used NMR and other biophysical methods to examine ligand-induced structural changes and the dynamics of unliganded RGS4 and RGS8 that allow ligand binding. NMR and fluorescence spectroscopy data reveal details of the hidden, excited conformational state of RGS4 that exposes Cys148, one of th

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45

CALLEA, LARA. "MODELING OF LIGAND-PROTEIN BINDING WITH ADVANCED MOLECULAR DYNAMICS METHODS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/374733.

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Questa tesi è incentrata sulla modellazione del binding ligando-proteina con metodi computazionali basati sulla dinamica molecolare. La comprensione di questo processo è fondamentale per la progettazione e la scoperta di nuovi farmaci e l'uso di metodi computazionali per supportare la ricerca sperimentale in questo campo è in costante crescita. Oggi, grazie alla crescente potenza dei computer, è possibile studiare l'intero processo di binding/unbinding del ligando e ottenere stime sulle proprietà termodinamiche e cinetiche. Alla luce di ciò, durante il mio dottorato, diversi metodi avanzati d

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Giberson, Andrea N. "Adenovirus Chromatin: The Dynamic Nucleoprotein Complex Throughout Infection." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24931.

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Adenovirus (Ad) is a widely studied DNA virus, but the nucleoprotein structure of the viral genome in the cell is poorly characterized. Our objective is to study Ad DNA-protein associations and how these affect the viral life cycle. Most of the viral DNA condensing protein, protein VII, is lost within a few hours of infection and this loss is independent of transcription. Cellular histones associate with the viral DNA after removal of protein VII, with a preferential deposition of H3.3. Micrococcal nuclease accessibility assays at 6 hpi showed laddering of the viral DNA, suggesting the genome

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47

Vilaprinyó, Pascual Sílvia. "The dynamic nature of amyloid-beta protein aggregation and its association to Alzheimer’s disease." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/305364.

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Amyloid-beta protein (Aß) is strongly linked to the aetiology of Alzheimer’s disease (AD). Even though Aß has a central role in AD, this protein is normally produced in healthy humans. It is the aberrant processing of Aß that determines its accumulation and aggregation into large oligomer species that evolve into the fibrillar structures deposited in amyloid plaques in the brain of AD patients. The neurotoxicity observed in AD has been attributed to the oligomeric intermediates, although their stoichiometry and structure still remain unknown. This is the reason why no AD therapeutic approaches

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48

Siekmann, Arndt. "Dynamic visualization and genetic determinants of Sonic hedgehog protein distribution during zebrafish embryonic development." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1101915621750-69414.

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The correct patterning of embryos requires the exchange of information between cells. This is in part achieved by the proper distribution of signaling molecules, many of which exert their function by establishing gradients of concentration. Because of this property they were named &quot;morphogens&quot;, or &quot;form giving&quot; substances. Among these, proteins belonging to the Hedgehog (Hh) family have received much attention, owing to their unusual double lipid modification and their involvement in human disease, causing congenital birth defects and cancer. Great efforts h

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Nagarajan, Aparna. "Insights into the maintenance and repair of photosystem ii, a dynamic membrane protein complex." Thesis, Oklahoma State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3614386.

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<p> Photosystem II (PSII) is recognized as the main site for high light induced damage. One of the core subunits of PSII, D1 protein encoded by the <i> psbA</i> gene, is identified as a high turnover protein that undergoes degradation and replacement as a part of the repair process in PSII. Studies on D1 repair have shown the synchronous nature of D1 degradation and synthesis. FtsH a AAA protease, is known to cause D1 degradation. Therefore, it is widely speculated that damaged D1 is replaced by newly synthesized D1. Although, there is no direct evidence suggesting the removal of damaged subun

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Barata, David Miguel Baião. "Production of recombinant protein hLIF in static and dynamic systems of animal cell culture." Master's thesis, FCT - UNL, 2009. http://hdl.handle.net/10362/3324.

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Thesis for the Degree of Master of Science in Biotechnology Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia<br>The present work focuses the optimization of the production of human Leukemia Inhibitory Factor (hLIF) by human embryonic kidney 293 (HEK293) - EBNA1 cell line cultured as suspension aggregates in spinner flask. The effects of initial cell density and feeding-regime in cellular growth and productivity were evaluated. A first phase occurs until the end of exponential growth in medium containing serum, being followed by puromycin selection of cells containing hLIF p

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