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Dissertations / Theses on the topic 'Protein functional analysis'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Nguyen, Giang Huong. "A functional analysis of the human LPA₁G protein coupled receptor." Thesis, Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131304/unrestricted/nguyen%5Fgiang%5Fh%5F200405%5Fms.pdf.

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2

Akkoyun, Emrah. "Parallelization Of Functional Flow To Predict Protein Functions." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612932/index.pdf.

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Protein-protein interaction networks provide important information about what the biological function of proteins whose roles are unknown might be in a cell. These interaction networks were analyzed by a variety of approaches by running them on a single computer and the roles of the proteins identified were used to predict the function of the proteins unidentified. The functional flow is an approach that takes the network connectivity, distance effect, topology of the network with local and global views into account. With these advantages, that the functional flow produces more accurate result

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3

Tuason, Maria Clarita. "Functional analysis of Proteolipid Protein regulatory sequence." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101805.

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Myelin is an evolutionarily late acquisition of the vertebrate nervous system which speeds electrochemical signaling in mature nerve fibers by providing insulation in the form of a lipid-rich multilammelar sheath. Proteolipid Protein (PLP) is the most abundant protein in mature mammalian central nervous system myelin where it serves as a structural component in addition to other yet undefined roles. It is coordinately regulated at the transcriptional level with other myelin genes such as Myelin Basic Protein (MBP). The major components of MBP transcriptional regulation have been defined using

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4

Chodagam, Sasidhar. "Functional analysis of the centrosomal protein CP190." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619859.

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5

Mizuno, Nobuhiro. "Structure-based functional analysis of DsrD protein." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147845.

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6

Adams, Vicki 1976. "Functional analysis of the clostridial large resolvase TnpX." Monash University, Dept. of Microbiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/5729.

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7

Giorgini, Flaviano. "Functional analysis of the murine sequence-specific RNA binding protein MSY4 /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/10293.

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8

Caufield, J. Harry. "Interactomics-Based Functional Analysis: Using Interaction Conservation To Probe Bacterial Protein Functions." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4580.

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The emergence of genomics as a discrete field of biology has changed humanity’s understanding of our relationship with bacteria. Sequencing the genome of each newly-discovered bacterial species can reveal novel gene sequences, though the genome may contain genes coding for hundreds or thousands of proteins of unknown function (PUFs). In some cases, these coding sequences appear to be conserved across nearly all bacteria. Exploring the functional roles of these cases ideally requires an integrative, cross-species approach involving not only gene sequences but knowledge of interactions among the

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9

Yang, Long 1976. "Functional analysis of the loki serinethreonine protein kinase." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33859.

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In cell cycle checkpoint control, the Chk2 family protein kinases play a central role in mediating the cellular responses to DNA damage or DNA replication block. However, at the beginning of this project, there was no evidence for a Drosophila homologue of Chk2. loki was identified in a screen for serine/threonine protein kinases that are expressed in the ovary. Using a phylogenetic analysis, I showed that loki is a Drosophila chk2 orthologue. To characterize the checkpoint function of loki in Drosophila development, we created a loki null mutant and generated anti-Loki antibodies. Under norma

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10

Finnie, Nicholas James. "Functional analysis of the DNA-dependent protein kinase." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243027.

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11

Colgan, Kevin James. "Functional analysis of the herpesvirus Saimiri ORF57 protein." Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493560.

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Herpesvirus saimiri (HVS) is the prototype gamma-2-herpesvirus which has significant homology to the medically important Kaposi's sarcoma-associated herpesvirus (KSHV). HVS encodes an essential multifunctional protein, ORF57, which is conserved in all herpesviruses. ORF57 plays a pivotal role in transactivating viral gene expression by specifically mediating the nuclear export of intronless viral transcripts. To perform this function, ORF57 has the ability to shuttle between the nucleus and the cytoplasm, bind viral RNA and interact with various cellular proteins involved in nuclear import and

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12

Bishop, Anne Louise. "Functional analysis of the Rac binding protein POSH." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248466.

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13

MacIsaac, Fiona. "Functional analysis of INCENP, a chromosomal passenger protein." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/12510.

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The chromosomal passenger proteins display a distinctive pattern of localisation through mitosis. In human cells this group currently comprises six proteins; Survivin, Aurora-B, Aurora-C, INCENP, TD-60 and Borealin. To try and understand the functions of INCENP, various truncations have been expressed. The N-terminus of INCENP has previously been shown to be essential for targeting to the centromere when expressed ectopically. I have carried out a yeast two-hybrid screen in order to identify proteins that interact with this region of INCENP. This screen identified a number of potential INCENP

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14

MacDougall, Eilidh Fiona. "Functional analysis of the DNA repair protein MBD4." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12502.

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The methylation of cytosine plays a fundamental role in mediating transcriptional repression. However, 5-methylcytosine can undergo spontaneous hydrolytic delamination to form thymine. It the resulting T:G mismatch is replicated prior to being repaired, a C:G to T:A transition mutation will be present in one of the two daughter DNA molecules. Methyl-CpG-binding domain protein 4 (MBD4) is a DNA glycosylase that can excise thymine from mismatches with guanine, and that acts preferentially on T:G mismatches within CpG dinucleotides <i>in vitro</i>. In order to test the hypothesis that MBD4 repair

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15

Eifan, Saleh A. "Functional analysis of the orthobunyavirus nucleocapsid (N) protein." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/542.

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16

Wright, Jane F. "Structural and functional analysis of the IκBα protein". Thesis, University of St Andrews, 1997. http://hdl.handle.net/10023/14514.

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NF-KB/Rel transcription factors and IKB proteins play a central role in the rapid induction of genes transcribed in response to a variety of extracellular stimuli. Signal induction results in the phosphorylation and ubiquitination of IKBalpha a prior to proteasomal degradation and release of NF-KB. The objective of this work was to identify residues within the N- and C-termini of IKBalpha which were important for the function of the protein, specifically the residues contacting the p65 subunit of NF- KB and those involved in the turnover of IKBalpha. In addition, the structure of the C-termina

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17

Che, Azmi Norhaida. "Functional proteomic analysis of leukaemogenic protein tyrosine kinase targets." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/functional-proteomic-analysis-of-leukaemogenic-protein-tyrosine-kinase-targets(a6dc9816-886b-495f-a6e1-f00aec05382f).html.

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Myeloproliferative neoplasms (MPNs) are clonal proliferative disorders associated with JAK2 mutation (e.g JAK2 K539L, JAK2 V617F), MPL mutation (e.g MPL W515L) or product from reciprocal chromosomal translocations in many cases (e.g BCR/ABL). The mutated thrombopoietin receptor MPL W515L found in thrombocytosis and myelofibrosis is constitutively activated leading to a downstream signal transduction cascade activation including the JAK-STAT signalling pathway. MPL W515L induced JAK2 mutation is associated with polycythaemia vera. Using quantitative proteomics I have investigated the effects of

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18

Roemer, Sarah Clark. "Structural and functional analysis of progesterone receptor-DNA interaction /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 165-185). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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19

Nie, Yingchao. "Functional comparison and analysis of protein-protein interactions of Autographa californica multiple nucleopolyhedrovirus transregulatory proteins IE0 and IE1." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/20752.

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Autographa californica multiple nucleopolyhedrovirus expresses two major transregulatory proteins IE0 and IE1 immediately upon infection. IE0 differs from IE1 only by 54 additional N-terminal amino acids (aa). Either IE0 or IE1 can support viral replication; however both are required for a wild-type infection. It is unknown what the different functions of IE0 and IE1. Both IE0 and IE1 can transactivate viral early genes and support viral DNA replication. It is therefore hypothesized that by the addition of Nterminal 54 aa, IE0 acquires different transactivation activity on viral genes and inte

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20

Wong, Yee-man Kimmi. "Expression and functional analysis of a mutant sPDZD2 protein /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31540867.

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21

Dib, Kandis Badine Samar. "Functional analysis of the Myelin Basic Protein gene regulation." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32543.

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Through this investigation I hoped to illuminate and characterize any combinatorial relationships that might exist amongst the regulatory sequences that drive expression of the myelin basic protein gene. With such insight, I expected to learn more of the mechanism/s regulating myelin sheath formation, maintenance and repair. In the search for regulatory regions within the mbp gene, four highly conserved non-protein-coding modules were found in its 5' flanking sequence. In the context of reporter construct

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22

Elderkin, Sarah Louise. "Functional analysis of the E.coli phage shock protein PspA." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407101.

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23

Tolley, Nicholas Joseph. "Functional analysis of a reticulon protein from Arabidopsis thaliana." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/3802/.

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While our knowledge of the functional properties of eukaryotic cellular organelles is quite comprehensive, the mechanisms by which organelles achieve their varied shapes remain poorly understood. By categorising the components which contribute to the architecture of the cell, relationships between structure and function can be established. Many mechanisms have been proposed which try to account for the shape and structure of complex organelles such as mitochondria and, more recently, the endoplasmic reticulum (ER); an organelle which comprises multiple domains, both structurally and functional

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24

Wong, Yee-man Kimmi, and 黃綺雯. "Expression and functional analysis of a mutant sPDZD2 protein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010468.

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25

Fleck, Barbara. "Functional analysis of GAI, an Arabidopsis gibberellin signalling protein." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247096.

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26

Mirotsou, Maria. "Functional analysis of the ID4 protein by conditional overexpression." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368698.

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27

Myant, Kevin Brian. "Functional analysis of the SWI/SNF family protein LSH." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/11214.

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The aims of this study were to characterise the molecular function of LSH and attempt to relate this to its role in DNA methylation <i>in vivo</i>. To address these aims the work described in this thesis uses a variety of approaches to address two key questions. (1) Is LSH an active SNF2 ATPase? (2) How does LSH interaction with, and modulate, the DNA methylation machinery? To determine if LSH is an active SNF2 ATPase, recombinant LSH was purified from insect cells and biochemically characterised. These experiments revealed that LSH can hydrolyse ATP and its activity is stimulated by DNA. Howe

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28

Alsaif, Omar M. "The PM19 protein : a functional analysis in Arabidopsis thaliana." Thesis, Heriot-Watt University, 2014. http://hdl.handle.net/10399/2772.

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The amino acid sequence of the trans-membrane protein, PM19, unique to the plant kingdom has been highly conserved over 450 million years of evolution in all plant genera including ferns and mosses, but is not found in aqueous plants such as algae. Thus, the function of this protein is possibly linked to the plant ability to grow on land. We have investigated the PM19 protein using a number of molecular biological tools in Arabidopsis thaliana. Gene expression studies using bioinformatics, northern blotting and promoter-GUS fusions show that the AtPM19 gene is highly expressed in seeds and see

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29

Miki, Takayuki. "Protein functional analysis and proteomics by novel chemical labeling." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215576.

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30

Allen, Carl E. "Functional analysis of the large zinc finger protein, KRC /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu14881967817341.

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31

Ruiz, Arroyo Víctor Manuel. "Structural and functional analysis of Zika Virus NS5 protein." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671922.

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Zika virus (ZIKV) belongs to the Flaviviridae family and constitute an important public health concern since ZIKV infection produced devastating effects in new born infants. Flaviviruses present a positive sense single stranded RNA genome flanked by highly structured untranslated regions (UTR) carrying one open reading frame that codifies for three structural proteins (C, prM, E) and five nonstructural proteins (NS1-5). At the most C-terminal end, NS5 protein carries a RNA dependent RNA polymerase (RdRP) and a methyl transferase domain (MTase) for genome copying and 5’ capping activities of th

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32

Schwamb, Bettina. "Functional analysis of the APAF-1 binding protein FAM96A." Phd thesis, Bettina Schwamb, 2013. http://tuprints.ulb.tu-darmstadt.de/3436/7/BS_Dissertation%20.pdf.

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Apoptosis, as a special form of programmed cell death (PCD) is an essential developmental process that is involved in tissue homeostasis and, whose deregulation has severe pathological implications for an organism. Thus, the evasion of the apoptotic program is one hallmark capability of cancer cells. Tumor suppressor genes (TSG) under normal conditions fulfill functions like sensing DNA-damage or regulating gene expression and they may contribute to the induction of apoptosis. In most cancer cells, TSG are mutated, inactivated or their expression level is reduced to enable neoplastic outgrowth

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33

Bolt, Mark W. "Structural and functional analysis of the Drosophila fat protein /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9842509.

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34

Deaton, John Franklin. "Solubilization and functional analysis of the lambda holin." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1211.

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The 105aa lambda S protein is the prototype holin, S accumulates in the cytoplasmic membrane during late gene expression until, at a time programmed into its primary structure, it disrupts the membrane and allows the lambda lysozyme, R, to attack the cell wall. In this study, a zwitterionic detergent Empigen BB, was used to extract and purify the lambda holin S. In Empigen BB, CD analysis on S gave 54% alpha helical content, consistent with 3 TM domains, which has been reported by other in vivo studies. Empigen BB-purified S can be exchanged into a chaotropic solution by dialysis and reconsti

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35

Li, Hongye, and 李宏業. "Functional analysis of ACBP2, an arabidopsis acyl-CoA binding protein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B29866200.

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36

El, Jai Yasmine. "Functional analysis of the cytoskeletal protein talin2 using gene disruption." Thesis, University of Leicester, 2006. http://hdl.handle.net/2381/29711.

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Talinl is a large, ubquitously expressed cytoskeletal protein that couples integrins to the actin cytoskeleton. Analysis of genomic and EST databases shows the presence of a second Tin gene encoding a closely related protein (75% identity in human), Tln2. Disruption of both Tlnl alleles in mouse results in early embryonic lethality. Although both talinl and talin2 are very similar in sequence and most probably bind the same ligands, talin2 cannot compensate for the loss of talinl in early mouse development. To further understand the role of talin2, analysis of talin2 expression at the mRNA and

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37

Li, Chunyang. "Functional analysis of Arabidopsis Flowering locus T RNA and protein." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/36849/.

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The transition to flowering is one of the major and important phase changes during the plant’s life cycle. It has been shown that multiple signalling pathways are involved in this process. Many of these pathways converge on the floral integrator gene FT. FT is activated in the leaves by an inducing signal (e.g. photoperiod) and then it moves to the shoot apex. At the apex, the FT protein interacts with FD to initiate floral development through transcriptional activation of APETALA1 and SOC1. Several papers have reported that the FT protein moves from leaf to the shoot apex and acts as the flow

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38

Perbal, Marie-Christine. "A functional analysis of the cauliflower mosaic virus movement protein." Thesis, University of East Anglia, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359335.

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39

Crofts, Andrew James. "Functional analysis of protein complexes in the plant endoplasmic reticulum." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323532.

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40

Wright, Casey Wyatt. "Functional analysis of the baculovirus anti-Apoptotic Protein OP-IAP /." Search for this dissertation online, 2003. http://wwwlib.umi.com/cr/ksu/main.

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41

Hopp, Christine S. "Functional analysis of the plasmodium falciparum cGMP-dependent protein kinase." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549762.

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42

Gone, Swapna. "Functional analysis of Ribonuclease III regulation by a viral protein kinase." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/159409.

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Chemistry<br>Ph.D.<br>The bacteriophage T7 protein kinase enhances T7 growth under suboptimal growth conditions, including elevated temperature or limiting carbon source. T7PK phosphorylates numerous E. coli proteins, and it has been proposed that phosphorylation of these proteins is responsible for supporting T7 replication under stressful growth conditions. How the phosphorylation of host proteins supports T7 growth is not understood. Escherichia coli (Ec) RNase III is phosphorylated on serine in bacteriophage T7-infected cells. Phosphorylation of Ec-RNase III induces a ~4-fold increas

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43

Reddy, Joseph. "Identification and Analysis of Important Proteins in Protein Interaction Networks Using Functional and Topological Information." Thesis, University of Skövde, School of Life Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-2395.

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<p>Studying protein interaction networks using functional and topological information is important for understanding cellular organization and functionality. This study deals with identifying important proteins in protein interaction networks using SWEMODE (Lubovac, et al, 2006) and analyzing topological and functional properties of these proteins with the help of information derived from modular organization in protein interaction networks as well as information available in public resources, in this case, annotation sources describing the functionality of proteins. Multi-modular proteins are

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44

Liu, Ziqiang. "Molecular analysis and functional characterization of Nucleosome Assembly Protein 1 (NAP1) family proteins in plants." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13132.

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Eukaryotic genomes are packaged into chromatin, a regularly repeated structure whose fundamental building block is the nucleosome. Each nucleosome core particle is composed of a histone octamer consisting of two molecules each of the core histones H2A, H2B, H3, and H4, around which approximately 146–147 bp of DNA is wrapped. The assembly of nucleosome is the first step of chromatin assembly which is important for the chromatin structure affecting a broad ranges of biological events including DNA replication, repair, recombination, transcription, cell differentiation, proliferation, and organis

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45

Geng, Ruishuang. "Characterization and functional analysis of ZEITLUPE protein in the regulation of the circadian clock and plant development." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149013919.

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46

Dahal, Liza. "Functional relevance of protein disorder : why is disorder favourable?" Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283008.

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For half a century, the central tenet of protein science has been grounded on the idea that the three-dimensional structure of a protein underlies its function. However, increasing evidence of natively unstructured but functional proteins is accumulating. Termed as intrinsically disordered proteins (IDPs), they populate a number of different conformations in isolation. Interestingly, as part of their function, some IDPs become fully or partly structured upon interaction with their binding partners. This process, known as coupled folding and binding raises the question what comes first - foldin

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47

Mason, Aaron Charles. "Functional analysis of an alternative Replication Protein A complex containing RPA4." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/1020.

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Replication Protein A (RPA), the eukaryotic single-stranded DNA-binding complex, is essential for multiple processes in cellular DNA metabolism including, but not limited to, DNA replication, DNA repair and recombination. The `canonical' RPA is composed of three subunits (RPA1, RPA2, and RPA3). In addition to the three canonical subunits, there is a human homolog to the RPA2 subunit, termed RPA4, which can substitute for RPA2 in complex formation. The resulting RPA complex has been termed `alternative' RPA (aRPA). The normal function of aRPA is not known; however, previous studies have shown t

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48

Macintosh, Robin. "Functional analysis of the accumulation associated protein (Aap) of Staphylococcus epidermidis." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/functional-analysis-of-the-accumulation-associated-protein-aap-of-staphylococcus-epidermidis(7263efcb-5e62-4998-9ebf-24f2520e67d1).html.

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S. epidermidis is one of the primary opportunistic pathogens associated within dwelling medical devices such as intravenous catheters and artificial heart valves and joints. S. epidermidis is also a permanent commensal resident on human skin and mucus membranes providing a large potential reservoir for the contamination of medical implants. Persistent colonisation of implants occurs via biofilm formation and infected implants must usually be replaced. The surface bound protein, accumulation associated protein (Aap), is one of the main biofilm promoting surface molecules on S. epidermidis. Aap

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49

Nambudiry, Rekha *. "Analysis Of Structural And Functional Types Of Protein-Protein Interactions." Thesis, 2005. https://etd.iisc.ac.in/handle/2005/1497.

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Nambudiry, Rekha *. "Analysis Of Structural And Functional Types Of Protein-Protein Interactions." Thesis, 2005. http://etd.iisc.ernet.in/handle/2005/1497.

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