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Dissertations / Theses on the topic 'Protein Kinase, c-Src'

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Published: 14 March 2023

Last updated: 31 July 2025

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1

Gatesman, Ammer Amanda. "PKCalpha direct cSrc activation and podosome formation through the adaptor protein AFAP-110." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3762.

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Thesis (Ph. D.)--West Virginia University, 2004<br>Title from document title page. Document formatted into pages; contains vii, 350 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 322-346).

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2

Molinari, Alessio. "Design, synthesis and biological evaluation of novel small molecules inhibitors of c-Src, Hck and TAK1 Protein Kinases for treatment of cancer disease." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1048703.

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The interest in protein kinase had been improved in recent years since the entry into the market of the first protein Kinase inhibitor. In this thesis have been designed, and synthesized new small molecules able to inhibit separately three different kinases, c-Src, Hck and TAK1, widely implicated in cancer disease. Protein kinases catalyse the transfer of phosphate groups from nucleoside triphosphates, usually adenosine triphosphate (ATP), to specific serine, threonine, or tyrosine residues in substrate proteins as a way of regulating their activities1,2. Deregulation of their activities can l

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3

Summy, Justin Matthew. "Functional domain contributions to signaling specificity between the non-receptor tyrosine kinases c-src and c-yes." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2239.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains vi, 195 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 182-190).

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4

Lin, Xiaofeng. "Probing the regulatory mechanisms of protein tyrosine kinases, using C-terminal SRC kinase (CSK) as a model system /." View online ; access limited to URI, 2005. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3188064.

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5

Baisden, Joseph M. "AFAP-110 is a cSrc activator." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2766.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains v, 149 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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6

Lou, Qiang 1962. "Identification of peptide substrates and development of pseudosubstrate-based peptide inhibitors for p60(C-SRC) protein tyrosine kinase." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/282230.

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Protein tyrosine kinases (PTKs) mediate important signaling events associated with cellular growth, differentiation, and mitogenesis. The p60c-src protein is the first described cellular protein tyrosine kinase. Human p60c-src PTK has been implicated in the development of colon and breast cancer, and leukemia. However, the exact physiological role of p60c-src PTK or its physiological target proteins are not well known, and the mechanism by which the p60c-src PTK activity is regulated is not completely understood. Peptide substrates can be used to determine the substrate specificity and kinetic

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7

Song, Jaekyung Cecilia. "Protein Kinase C-δ and Protein Kinase C-ε Cooperatively Enhance Epithelial Cell Spreading via Transactivation of Epidermal Growth Factor Receptor and Actin-Dependent Phosphorylation of Focal Adhesion-Associated Proteins". Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1132198567.

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Thesis (Ph. D.)--University of Cincinnati, 2005.<br>Title from electronic thesis title page (viewed Sept. 13, 2007). Includes abstract. Keywords: Protein Kinase C; Cell spreading; Cell migration; Epithelial Cells; Epidermal Growth Factor Receptor; Transactivation; Focal Adhesion; Actin; Focal Adhesion Kinase; Src; Paxillin Includes bibliographical references.

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8

Koh, Wonshill. "Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6045.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2008" Includes bibliographical references.

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9

Lennartsson, Johan. "Stem Cell Factor Induced Signal Transduction." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5291-4/.

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10

Wortmann, Andreas. "In vitro and in vivo examination of the cell surface glycoprotein CDCP1." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/40975/1/Andreas_Wortmann_Thesis.pdf.

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A number of reports have demonstrated the importance of the CUB domaincontaining protein 1 (CDCP1) in facilitating cancer progression in animal models and the potential of this protein as a prognostic marker in several malignancies. CDCP1 facilitates metastasis formation in animal models by negatively regulating anoikis, a type of apoptosis triggered by the loss of attachment signalling from cell-cell contacts or cell-extra cellular matrix (ECM) contacts. Due to the important role CDCP1 plays in cancer progression in model systems, it is considered a potential drug target to prevent the metast

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11

Mongaret, Céline. "Etude du rôle de la protéine ADAM9 et de son isoforme sécrétée dans les processus de migration et d’angiogenèse tumoraux." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T054/document.

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L’invasion métastatique des tumeurs humaines est un mécanisme complexe qui repose sur l’acquisition de nouvelles fonctionnalités par les cellules tumorales. Les protéines ADAM et plus particulièrement la protéine ADAM9, grâce à leur domaine extracellulaire se composant d’une activité métalloprotéasique et disintégrine, possèdent des fonctions importantes et nécessaires au processus d’invasion. Cependant, les mécanismes de régulation de la protéine restent globalement méconnus dans la pathologie cancéreuse. L’objectif de ce travail a consisté à évaluer le rôle de l’expression d’ADAM9 dans les m

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12

Morel, Marion. "Les récepteurs venus kinase (VKRs) de schistosoma mansoni : étude des voies de signalisation de SmVKR1 et rôle de la protéine adaptatrice SmShb." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S003/document.

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La schistosomiase est une parasitose causée par un ver plat trématode du genre Schistosoma. Cette pathologie, responsable de près de 300 000 décès par an, est essentiellement due à la forte fécondité des vers et à l’accumulation des œufs dans les tissus de l’hôte. Pour lutter contre la pathologie, un seul traitement efficace, le Praziquantel, est utilisé en masse dans les régions endémiques. Afin de parer à l’apparition de résistances au Praziquantel, le développement de molécules régulant la ponte du parasite fait partie des solutions alternatives envisagées.Les récepteurs Venus Kinase (VKRs)

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13

Lo, Kin Ho. "Activation of signal transducer and activator of transcription 3 (STAT3) by G[alpha]16 and G[alpha]14 via a c-Src/JAK-and ERK-dependent mechanism /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20LO.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2004.<br>Includes bibliographical references (leaves 92-111). Also available in electronic version. Access restricted to campus users.

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14

Le, Roux Anabel-Lise. "N-Myristoylation-Dependent c-Src Interactions." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/346927.

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c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the intrinsically disordered N-terminal SH4 and Unique domains, of the folded SH3, SH2, kinase domains and of a C-terminal tail. c-Src is myristoylated at its N-terminal region and anchored to membranes via cooperative electrostatic and hydrophobic interactions. Weak interactions with lipids in the Unique and SH3 domains and intramolecular interactions between them were recently f

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15

Banin, Sharon. "Identification and characterisation of the interaction between Wiskott-Aldrich Syndrome Protein (WASP) and c-src kinases." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264343.

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16

Mohammad, Jabeen Irrem Laareb. "Insights into the myristoylated c-Src N-terminal Regulatory Element." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672570.

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c-Src is a non-receptor tyrosine kinase that controls numerous cellular signaling pathways. c-Src implication in human cancers was brought into the attention in the 1980s. Since its discovery, unveiling of c-Src structural architecture and subsequent regulatory function focused on the folded domains cassette SH3-SH2-SH1(kinase), while the remaining N-terminal intrinsically disordered myristoylated SH4 and Unique domains were assumed to have a membrane-connecting function. c-Src membrane binding has been well-characterized as a two-prong association requiring the burial of its myrist

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17

Arbesú, Andrés Miguel. "A novel regulatory unit in the N-terminal region of c-Src." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/543572.

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c-Src is a central player in several cellular signaling pathways. It controls impor- tant cellular processes like cellular proliferation, survival or motility. Therefore, a number of tumoral diseases have been related to abnormal c-Src activity. Among them, colorectal cancer stands out, as c-Src deregulation correlates with tumor progression and clinical outcome. This tyrosine kinase is part of a larger group of functionally and structurally related proteins termed Src Family Kinases. These proteins share the same domain architecture: a cassette formed by a catalytic domain (SH1), two reg- u

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18

Saade, Khalil. "Identification of a potent anti-invasive molecule through mixed targeting design." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116059.

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The altered protein expression and activity of receptor tyrosine kinases (TK) are implicated in the progression of various types of cancers. One such dysfunction is the overexpression of the epidermal growth factor receptor (EGFR) that correlates with aggressive tumor progression and poor prognosis. On the other hand, c-Src non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been strongly linked to progression to distant metastases. c-Src-induced phosphorylation of EGFR is required for EGF-mediated mitogenesis, tumorigenesis and tumour in

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19

Jallal, Houda. "A Src-Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth and metastasis in vitro and in vivo /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112641.

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The central role of Src in the development of several malignancies including breast cancer and the accumulating evidence of its interaction with receptor tyrosine kinases (RTK), integrins and steroid receptors have identified it as an attractive therapeutic target. In the current study we have evaluated the effect of a Src/Abl kinase inhibitor SKI-606, on breast cancer growth, migration, invasion and metastasis. Treatment of human breast cancer cells MDA-MB-231 with SKI-606 caused a marked inhibition of cell proliferation, invasion and migration by inhibiting MAPK and Akt phosphorylation. For

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20

Ma, Qiuping. "Role of FoxO Factors as the Nuclear Mediator for PTEN-AR Antagonism in Prostate Cancer Cells." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002559.

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21

Yang, Xiaoqing. "Dissection of α6β4 Integrin-Dependent Signaling and Breast Carcinoma Invasion: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/563.

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Breast cancer is one of the most prevalent cancers in the world. Each year, over 400,000 women die from breast cancer world wide and metastasis is the main cause of their mortality. Tumor cell invasion into the adjacent tissue is the first step in the multistep process of cancer metastasis and it involves multiple protein changes. The α6β4 integrin, a transmembrane heterodimeric laminin receptor is associated with poor prognosis in many tumor types, including breast cancer. Src family kinase (SFK) activity is elevated in many cancers and this activity also correlates with invasive tumor behavi

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22

Vendrell, Arasa Alexandre. "SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7153.

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L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2

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23

Tice, David Alan. "The role of C-SRC in tumorigenesis /." 1999. http://wwwlib.umi.com/dissertations/fullcit/9930109.

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24

Wen-Tsuo, Lin, and 林玟佐. "Roles of protein kinase C and Src family tyrosine kinase in RhoA activity in thoracic aortae from endotoxemic rats." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/49987676452794619383.

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碩士<br>國防醫學院<br>藥理學研究所<br>98<br>Sepsis is the systemic inflammatory response with infection. Usually, septic shock is occurred at the late phase of sepsis. Septic shock is characterized by severe hypotension and reduced response to vasopressor agents, called vascular hyporeactivity. The hypotension and vascular hyporeactvity are associated with the development of multiple organs dysfunction which causes death eventually. Thus, it is important to investigate the mechanism of vascular hyporeactivity in septic shock. Among the cell signaling pathways that are crucial to control vascular tone, Ca2+

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25

Roof, Richard W. "C-SRC phosphorylation of P190 RHOGAP : regulation of P190/P120 RASGAP interaction /." 1999. http://wwwlib.umi.com/dissertations/fullcit/9916398.

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26

Batuello, Christopher N. "Phospho-regulation and metastatic potential of Murine Double Minute 2." Thesis, 2012. http://hdl.handle.net/1805/3195.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Murine double minute (Mdm2) is a highly modified and multi-faceted protein that is overexpressed in numerous human malignancies. It engages in many cellular activities and is essential for development since deletion of mdm2 is lethal in early stages of embryonic development. The most studied function of Mdm2 is as a negative regulator of the tumor suppressor protein p53. Mdm2 achieves this regulation by binding to p53 and inhibiting p53 transcriptional activity. Mdm2 also functions as an E3 ubiquitin ligase that signals p53 for dest

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27

Potůčková, Lucie. "Regulační úlohy proteinů PAG a CSK v FcɛRI signalizaci žírných buněk". Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-357604.

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8 1 ABSTRACT (EN) This thesis is focused mainly on understanding mechanisms of regulatory roles of C-terminal Src kinase (CSK) and phosphoprotein associated with glycosphingolipid- enriched microdomains (PAG) in the high-affinity IgE receptor (FcɛRI)-mediated signaling of murine mast cells. FcɛRI activation is initiated by aggregation of the receptor by complexes of multivalent antigen with IgE, followed by activation and enhanced activities of protein tyrosine kinases, phosphatases, adaptor proteins and number of other signal transduction molecules. The signaling events result in mast cell de

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28

Vielreicher, Martin Christian. "Fluoreszenz-mikroskopische Untersuchung der Inaktivierung der Tyrosinkinase SRC im Integrin alphaIIb-beta3 -Signalweg." Doctoral thesis, 2008. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-26743.

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Essentiell für die Blutstillung (Haemostase) ist die Thrombozyten- oder Blutplaettchen-Adhaesion und die Thrombus-Bildung. Beide Vorgaenge werden hauptsaechlich durch den Thrombozyten-Rezeptor Integrin alphaIIb-beta3 vermittelt. Nach Bindung des Liganden Fibrinogen aendert sich die Rezeptor-Konformation, Integrine assoziieren und ein intrazellulaeres Signalnetzwerk wird aktiviert, welches die Organisation des Aktin-Zytoskeletts steuert. Diese Zytoskelett-Reorganisationen sind Grundlage für zellulaere Adhaesions- und Aggregations-Prozesse. Die Signalvermittlung vom Integrin zum Zytoskelett wird

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29

Vardatsikos, George. "Role of receptor and non-receptor protein tyrosine kinases in vasoactive peptide-induced signaling." Thèse, 2012. http://hdl.handle.net/1866/12777.

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L'endothéline-1 (ET-1) et l'angiotensine II (Ang II) jouent un rôle important dans le maintien de la pression artérielle et l'homéostasie vasculaire. Une activité accrue de ces peptides vasoactifs est présumée contribuer au développement de pathologies vasculaires, telles que l'hypertension, l'athérosclérose, l'hypertrophie et la resténose. Ceci est causé par une activation excessive de plusieurs voies de signalisation hypertrophiques et prolifératives, qui incluent des membres de la famille des Mitogen Activated Protein Kinases (MAPK), ainsi que la famille phosphatidylinositol 3-kinase (PI3-K

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30

Busch, F., A. Mobasheri, P. Shayan, C. Lueders, R. Stahlmann, and M. Shakibaei. "Resveratrol modulates interleukin-1beta-induced phosphatidylinositol 3-kinase and nuclear factor kappaB signaling pathways in human tenocytes." 2012. http://hdl.handle.net/10454/5903.

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Resveratrol, an activator of histone deacetylase Sirt-1, has been proposed to have beneficial health effects due to its antioxidant and anti-inflammatory properties. However, the mechanisms underlying the anti-inflammatory effects of resveratrol and the intracellular signaling pathways involved are poorly understood. An in vitro model of human tenocytes was used to examine the mechanism of resveratrol action on IL-1beta-mediated inflammatory signaling. Resveratrol suppressed IL-1beta-induced activation of NF-kappaB and PI3K in a dose- and time-dependent manner. Treatment with resveratrol enhan

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