Academic literature on the topic 'Protein LMs'
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Journal articles on the topic "Protein LMs"
Garcia, Natalia, Ayman Al-Hendy, Edmund C. Baracat, Katia Candido Carvalho, and Qiwei Yang. "Targeting Hedgehog Pathway and DNA Methyltransferases in Uterine Leiomyosarcoma Cells." Cells 10, no. 1 (December 31, 2020): 53. http://dx.doi.org/10.3390/cells10010053.
Full textPlaat, Boudewijn E. C., Harry Hollema, Willemina M. Molenaar, Gerben H. Torn Broers, Justin Pijpe, Mirjam F. Mastik, Harald J. Hoekstra, Eva van den Berg, Rik J. Scheper, and Winette T. A. van der Graaf. "Soft Tissue Leiomyosarcomas and Malignant Gastrointestinal Stromal Tumors: Differences in Clinical Outcome and Expression of Multidrug Resistance Proteins." Journal of Clinical Oncology 18, no. 18 (September 18, 2000): 3211–20. http://dx.doi.org/10.1200/jco.2000.18.18.3211.
Full textSparić, Radmila, Mladen Andjić, Ivana Babović, Lazar Nejković, Milena Mitrović, Jelena Štulić, Miljan Pupovac, and Andrea Tinelli. "Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review." International Journal of Molecular Sciences 23, no. 17 (August 27, 2022): 9728. http://dx.doi.org/10.3390/ijms23179728.
Full textCeausu, Amalia Raluca, Alexandru Ciolofan, Alexandru Blidisel, Andrei Alexandru Cosma, Pusa Nela Gaje, and Octavian Cretu. "Chloride Intracellular Channel Protein 1 Expression and Angiogenic Profile of Liver Metastasis of Digestive Origin." Current Issues in Molecular Biology 45, no. 2 (February 6, 2023): 1396–406. http://dx.doi.org/10.3390/cimb45020091.
Full textSafonova, L. A., M. M. Bobrova, O. I. Agapova, A. Yu Arkhipova, A. V. Goncharenko, and I. I. Agapov. "FIBROIN SILK BASED FILMS FOR RAT’S FULL-THICKNESS SKIN WOUND REGENERATION." Russian Journal of Transplantology and Artificial Organs 18, no. 3 (November 17, 2016): 74–84. http://dx.doi.org/10.15825/1995-1191-2016-3-74-84.
Full textAzzimato, Valerio, Jennifer Jager, Ping Chen, Cecilia Morgantini, Laura Levi, Emelie Barreby, André Sulen, et al. "Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance." Science Translational Medicine 12, no. 532 (February 26, 2020): eaaw9709. http://dx.doi.org/10.1126/scitranslmed.aaw9709.
Full textBöhm, Michael J., Ralf Marienfeld, Daniela Jäger, Kevin Mellert, Adrian von Witzleben, Silke Brüderlein, Mathias Wittau, et al. "Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib." Sarcoma 2019 (January 21, 2019): 1–10. http://dx.doi.org/10.1155/2019/3914232.
Full textDe Gregorio, Amelie, Inga Bekes, Nikolaus de Gregorio, Sophia Andres, Diego Hoffmeister, Tatjana Swerev, Thomas W. P. Friedl, Wolfgang Janni, and Florian Ebner. "Comparison of preoperative serum VEGF in leiomyosarcoma and uterus myomatosus patients: A proof of concept study." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e17117-e17117. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17117.
Full textTerés, Raul, Paula Cerdà, Ana Sebio, Pablo Gallardo, Aida Bujosa, Maria Borrell, Berta Martin, et al. "Evaluation of dystrophin expression by immunohistochemistry as a prognostic factor in leiomyosarcomas (LMS)." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e23525-e23525. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e23525.
Full textGonzalez-Molina, Jordi, Paula Hahn, Raul Maia Falcão, Georgia Kokaraki, Jorge Estefano de Souza, Tirzah Braz Petta Lajus, Kaisa Lehti, and Joseph W. Carlson. "Abstract 6096: The microarchitecture and fibrillar collagen expression of leiomyosarcoma are associated with malignancy." Cancer Research 82, no. 12_Supplement (June 15, 2022): 6096. http://dx.doi.org/10.1158/1538-7445.am2022-6096.
Full textDissertations / Theses on the topic "Protein LMs"
Batzenschlager, Morgane. "Diversité fonctionnelle des protéines GIPs/MZT1 (Gamma-tubulin complex protein 3- Interacting Proteins/Mitotic spindle organiZing proTein1) à l'interface nucléo-cytoplasmique chez Arabidopsis thaliana." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ030.
Full textIn Arabidopsis, the nuclear envelope is a nucleation center where gamma-tubulin complexes initiate the polymerization of microtubules. Conserved from plants to humans, GIPs/MZT1 proteins were initially discovered as AtGCP3 interacting partners. Our investigations were devoted to the molecular and functional characterization of AtGIPs and their associated proteins at the nucleocytoplasmic interface. We confirmed that AtGIPs are integral components of gamma-tubulin complexes, and showed that they interact with each other, TSA1 (TonSoKu [TSK]-Associating protein 1) and centromeric histone H3 (CenH3). Genetic interactions between GIPs, TSA1 and TSK reveal severe defects at the organism, cellular and nuclear scales. gip1gip2 mutants exhibit a decrease of centromeric and pericentromeric cohesion. Altogether, this is the first evidence for the role of a gamma–tubulin complex component in the structural maintenance of centromeric regions, and in defining nuclear morphology and architecture
Ghanim, Mustafa. "Les aspects génétiques des démences frontotemporales." Paris 6, 2010. http://www.theses.fr/2010PA066039.
Full textGuillaud, Laurent. "Étude de la localisation et du rôle fonctionnel des protéines STOP dans les cellules neuronales." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10160.
Full textDurand, Jean-Pierre. "Contribution a l'etude du groupe des proteines nucleaires de faible mobilite electrophoretique (lmg)." Nantes, 1988. http://www.theses.fr/1988NANT2010.
Full textObiol, Pardo Cristian. "Disrupting the protein-protein recognition in cancer pathways by molecular modeling." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/2759.
Full textOverexpression of antiapoptotic genes has been correlated with tumor growth and resistance to
chemotherapy, thus many efforts have been done to block the activity of XIAP and Survivin, central proteins acting in apoptosis and studied in the present work. Moreover, the two most active proteins detected in both the oxidative and nonoxidative branches of the pentose phosphate pathway, Glucose-6-Phosphate Dehydrogenase (G6PDH) and Transketolase (TKT), have been also selected in this thesis.
Molecular Modeling methods, covering topics in protein and peptide recognition, molecular dynamics, pharmacophore generation, database searching, docking and scoring in virtual screening and binding free energy prediction, have been applied with success to discover new active molecules inhibitors of XIAP, Survivin, G6PDH and TKT proteins.
TÍTULO: "Ruptura del reconocimiento proteína-proteína en rutas tumorales mediante modelización
molecular".
TEXTO:
El cáncer es el segunda causa de muerte por enfermedad en los paises industrializados. A pesar de la existencia de métodos eficaces de detección precoz y tratamientos cada vez más efectivos responsables de la reducción de mortalidad, algunos tipos de tumores presentan todavía tratamientos difíciles y bajos índices de supervivencia. Los fármacos convencionales sólo exhiben un índice terapéutico moderado, entre células sanas y tumorales, por ello los avances recientes se centran en encontrar tratamientos menos tóxicos para esta enfermedad. Así pues, los fármacos del futuro deberán incidir en rutas biológicas específicas, involucrando el crecimiento celular y la
proliferación descontrolada. Siguiendo este planteamiento, en este trabajo se han seleccionado dos mecanismos biológicos involucrados en el cáncer, llamados apoptosis (o muerte celular programada) y ruta de las pentosas fosfato, con el objetivo de encontrar nuevos inhibidores de las proteínas más sensibles de ambas rutas.
La sobreexpresión de genes antiapoptóticos se ha correlacionado con el crecimiento tumoral y la
resistencia a los tratamientos habituales. Así, se está trabajando en entender el funcionamiento de dos proteínas importantes de esta ruta, el XIAP y el Survivin, las cuales se han seleccionado en este trabajo, debido a que todavía no existen fármacos en el mercado que actúen sobre estas dos proteínas y debido a que su interés terapéutico se ha demostrado claramente.
Por otro lado, en este trabajo también se han estudiado las dos proteínas más activas detectadas en la rama oxidativa y no oxidativa de la ruta de las pentosas fosfato, la Glucosa-6-Fosfato Deshidrogenasa y la Transketolasa.
El objetivo principal ha consistido en aplicar métodos de la Modelización Molecular, que cubren
tópicos recientes, como el reconocimiento de péptidos y proteínas, la búsqueda en bases de datos, el anclaje y evaluación del cribado virtual de compuestos y la predicción de energías libres de unión, para encontrar nuevos inhibidores de las proteínas XIAP, Survivin, Glucosa-6-Fosfato Deshidrogenasa y Transketolasa.
Masoud, Kinda. "Caractérisation moléculaire et fonctionnelle des protéines GIPs (Gamma-tubulin complex protein 3-Interacting Proteins) d'Arabidopsis thaliana." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ011/document.
Full textMicrotubules (MTs) constitute one of the cytoskeletal networks in eukaryotic cells. They are involved in various processes such as cell division, intracellular transport and cell morphogenesis. In higher plants, MTs can be organized into dynamic structures, which undergo continual assembly and disassembly during the cell cycle. This specificity requires the recruitment of the nucleation complexes of the MTs to the nuclear envelope, to the cortex and to pre-existing MTs. The work of A. C. Schmit’s team (IBMP, CNRS, Strasbourg), in which I did my thesis, focuses on the characterization of MT nucleation complexes (γ-TuRCs) and the regulation of mitotic spindle assembly in plants. We have identified small proteins interacting with Gamma-tubulin Complex Protein 3 (GCP) and named GIP1 and GIP2 (GCP3-Interacting Proteins). The aim of these studies was to characterize this new class of proteins in order to understand their role. It shows that GIPs are conserved among eukaryotes and suggests that their association with the γ-TuRC participates in the regulation of their activity and the formation of a robust mitotic spindle. The localization of GIPs during the cell cycle and the phenotypes observed in T-DNA insertional gip1gip2 double mutants indicatethat GIPs are required for the recruitment of γ-TuRCs, MT nucleation, spindle assembly, cell cycle regulation and stem cell maintenance. Likewise, in vitro assays showed that GIP1 is a novel substrate for Aurora kinase1, which is a well known cell cycle regulator. The results of complementation experiments with GIP1 phosphomutants indicate that the phosphorylation of GIPs may be required for their function(s). Altogether, our results have contributed to the characterization of a new class of proteins involved in MT nucleation/organization and functions. The study of the interaction network (interactome) of GIPs and oftheir homologues could open new ways of research in the control of cell division and in the fight against cancer
Kwan, Ann Hau Yu. "Protein Design Based on a PHD Scaffold." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/564.
Full textKwan, Ann Hau Yu. "Protein Design Based on a PHD Scaffold." University of Sydney. Molecular and Microbial Biosciences, 2004. http://hdl.handle.net/2123/564.
Full textMoser, von Filseck Joachim. "Mécanismes du transport lipidique par les protéines ORP/Osh." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4138/document.
Full textAn uneven lipid distribution is essential for the function of eukaryotic organelles. However, exchange of material by vesicular trafficking has a tendency to perturb this distribution; mechanisms must though exist to ensure lipid homeostasis. Osh proteins (S. cerevisiae) and OSBP-Related Proteins (ORPs, H. sapiens), are lipid transfer proteins (LTPs). Osh4 is capable of exchanging ergosterol for phosphatidylinositol 4-phosphate (PI4P), found on the Golgi. Using novel fluorescent tools to measure with unprecedented precision the transport of sterol and PI4P, we find that Osh4 can transport sterol against its concentration gradient using the energy of a PI4P gradient. Coupled to phosphoinositide metabolism, this allows Osh4 to transport sterol to the trans-Golgi and create the sterol gradients observed between these organelles. OSBP participates in the creation of membrane contact sites (MCSs) via its capacity to connect ER membranes to those of the trans-Golgi. We have shown that it uses PI4P for transporting cholesterol from the ER to the trans-Golgi by sterol/PI4P counterexchange, hence also autoregulating its tethering activity. Finally, the identification of phosphatidylserine as a ligand for Osh6 allowed us to analyze the possible extrapolation of the PI4P counterexchange mechanism. We have solved the crystal structure of Osh6 in complex with PI4P and have been able to follow counterexchange of PI(4)P and PS in vitro. Concluding, our studies allow us to suggest a general mechanism for ORP/Osh-mediated counterexchange of PI4P for other lipids to maintain lipid gradients between the ER and late membranes of the secretory pathway
Cook, Neil James. "Le gmp cyclique et la phototransduction chez les vertebres." Strasbourg 1, 1986. http://www.theses.fr/1986STR13147.
Full textBooks on the topic "Protein LMs"
Thomas, Pierre. Recherches biochimiques sur les protéiques de la levure. [Laval, Québec?: s.n.], 1997.
Find full textLaborde, Christian. Danse avec les ours: OPA sur les Pyrénées. Paris: Editions R. Deforges, 1992.
Find full textDomanick, Joe. To protect and to serve: The LAPD's century of war in the city of dreams. Los Angeles: Figueroa Press, 2003.
Find full textTo protect and to serve: The LAPD's century of war in the city of dreams. New York: Pocket Books, 1994.
Find full textDickmann, Nancy. La carne y las proteínas. Chicago, Ill: Heinemann Library, 2011.
Find full textNelson, Lim, ed. To protect and to serve: Enhancing the efficiency of LAPD recruiting. Santa Monica, CA: RAND, 2009.
Find full textSébastien, Lernould, ed. Les nouveaux militants. Paris: Petits matins, 2008.
Find full textTellería, Gabriel Loza. Adiós a las ideologías. La Paz: Plural Editores, 2008.
Find full textAdiós a las ideologías. La Paz: Plural Editores, 2008.
Find full textLes recettes Dukan: Mon régime en 350 recettes. [Paris]: Flammarion, 2011.
Find full textBook chapters on the topic "Protein LMs"
Zhao, Hongyu, Baolin Wu, and Ning Sun. "DNA-protein binding and gene expression patterns." In Institute of Mathematical Statistics Lecture Notes - Monograph Series, 259–74. Beachwood, OH: Institute of Mathematical Statistics, 2003. http://dx.doi.org/10.1214/lnms/1215091147.
Full textLapedes, Alan S., Bertrand Giraud, LonChang Liu, and Gary D. Stormo. "Correlated mutations in models of protein sequences: phylogenetic and structural effects." In Institute of Mathematical Statistics Lecture Notes - Monograph Series, 236–56. Hayward, CA: Institute of Mathematical Statistics, 1999. http://dx.doi.org/10.1214/lnms/1215455556.
Full textEdler, Lutz, and Janet Grassmann. "Protein fold class prediction is a new field for statistical classification and regression." In Institute of Mathematical Statistics Lecture Notes - Monograph Series, 288–313. Hayward, CA: Institute of Mathematical Statistics, 1999. http://dx.doi.org/10.1214/lnms/1215455559.
Full textLefèvre, G. "Le h-FABP (Heart Fatty Acid Binding Protein)." In Les biomarqueurs en médecine d’urgence, 121–26. Paris: Springer Paris, 2012. http://dx.doi.org/10.1007/978-2-8178-0297-8_16.
Full textArnold, Janine, Alexey Shapiguzov, Geoffrey Fucile, Jean-David Rochaix, Michel Goldschmidt-Clermont, and Lutz Andreas Eichacker. "Separation of Membrane Protein Complexes by Native LDS-PAGE." In Methods in Molecular Biology, 667–76. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-631-3_46.
Full text"Protein-based lms and coatings." In Edible Coatings and Films to Improve Food Quality, 26–91. CRC Press, 2011. http://dx.doi.org/10.1201/b11082-6.
Full textMohammed Ali Jassim, Marwa, Majid Mohammed Mahmood, and Murtada Hafedh Hussein. "Human Herpetic Viruses and Immune Profiles." In Innate Immunity in Health and Disease. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96340.
Full textIzuegbuna, Ogochukwu. "Inflammation-Based Markers of Nutrition in Cancer Patients." In Malnutrition [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104428.
Full textSwiderek, Kristine M., Michael L. Klein, Stanley A. Hefta, and John E. Shively. "Strategies for the removal of ionic and non-ionic detergents from protein and peptide mixtures for on- and off-line liquid chromatography mass spectrometry (LCMS)." In Techniques in Protein Chemistry, 267–75. Elsevier, 1995. http://dx.doi.org/10.1016/s1080-8914(06)80034-7.
Full textO'Cinneide, Colm. "Derechos sociales en Europa." In Mecanismos de garantía de los derechos sociales, 44–61. The Global Initiative for Economic, Social and Cultural Rights, 2021. http://dx.doi.org/10.53110/ckwl8281.
Full textConference papers on the topic "Protein LMs"
Jundt, Emily, Kaustav Majumder, and Bijesh Maharjan. "Does Soil Nutrient Management with Nitrogen Fertilizer Increase Protein Content in Leguminous Plants." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/qgrx4847.
Full textKelleher, Stephen, Wayne Saunders, and William Fielding. "Solubilized Proteins as a Fat Block in Production." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/xfuv8295.
Full textCaffrey, Martin. "Lipid Phase Behavior: Databases, Rational Design and Membrane Protein Crystallization." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192724.
Full textRivera Ocampo, Gloria, Diana Marcela Santos Cabrera, Gloria Emilse Buriticá Giraldo, and Tatiana Castañeda López. "¿En el estado colombiano a las personas intersexuales se les protege su libertad sexual?" In 6° Encuentro Nacional de Semilleros de Investigación Uniremington. Fondo Editorial Remington, 2017. http://dx.doi.org/10.22209/mensi.n6a25.
Full textParola, Abraham H., Nurith Porat, Valeria R. Caiolfa, David Gill, Lutz A. Kiesow, Mathew Weisman, S. Nemschitz, Dahlia Yaron, Karen Singer, and Ethel Solomon. "Membrane lipid-protein interactions modify the regulatory role of adenosine-deaminase complexing protein: a phase fluorometry study of a malignancy marker." In OE/LASE '90, 14-19 Jan., Los Angeles, CA, edited by Joseph R. Lakowicz. SPIE, 1990. http://dx.doi.org/10.1117/12.17776.
Full textSmall, Jeanne R., and Shane L. Larson. "Photoacoustic determination of fluorescent quantum yields of protein probes." In OE/LASE '90, 14-19 Jan., Los Angeles, CA, edited by Joseph R. Lakowicz. SPIE, 1990. http://dx.doi.org/10.1117/12.17694.
Full textNordlund, Thomas M. "Streak Camera Methods In Nucleic Acid And Protein Fluorescence Spectroscopy." In 1988 Los Angeles Symposium--O-E/LASE '88, edited by Joseph R. Lakowicz. SPIE, 1988. http://dx.doi.org/10.1117/12.945367.
Full textHudson, Bruce S., and Dan Harris. "T4 phage lysozyme: a protein designed for understanding tryptophan photophysics." In OE/LASE '90, 14-19 Jan., Los Angeles, CA, edited by Joseph R. Lakowicz. SPIE, 1990. http://dx.doi.org/10.1117/12.17690.
Full textLee, John W., Gary R. Holtom, and Dennis J. O'Kane. "Picosecond resolution study of intramolecular energy transfer in lumazine protein." In OE/LASE '90, 14-19 Jan., Los Angeles, CA, edited by Joseph R. Lakowicz. SPIE, 1990. http://dx.doi.org/10.1117/12.17750.
Full textRousslang, Kenneth W., Steve K. Buratto, D. Haynes, P. Heath, D. Holloway, John C. Hulteen, Lisa Dick, K. Stevenson, C. O. Harding, and J. B. Alexander Ross. "Time-resolved phosphorescence of proteins and polypeptides." In OE/LASE '90, 14-19 Jan., Los Angeles, CA, edited by Joseph R. Lakowicz. SPIE, 1990. http://dx.doi.org/10.1117/12.17735.
Full textReports on the topic "Protein LMs"
Shomer, Ilan, Louise Wicker, Uzi Merin, and William L. Kerr. Interactions of Cloud Proteins, Pectins and Pectinesterases in Flocculation of Citrus Cloud. United States Department of Agriculture, February 2002. http://dx.doi.org/10.32747/2002.7580669.bard.
Full textSaunders, Alexander. Proton Radiography at Los Alamos. Office of Scientific and Technical Information (OSTI), February 2017. http://dx.doi.org/10.2172/1345179.
Full textBarash, Itamar, and Robert Rhoads. Translational Mechanisms Governing Milk Protein Levels and Composition. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696526.bard.
Full textCarrillo Cruz, Yudy Andrea. La protección del agua y los derechos humanos de las futuras generaciones. Ediciones Universidad Cooperativa de Colombia, December 2022. http://dx.doi.org/10.16925/wpai.12.
Full textDel Pozo, Claudia May, Ana Victoria Martín del Campo Alcocer, and Mariana Róo Rubí. Aprendizaje en línea seguro: políticas y gobernanza para la protección de datos de los estudiantes en América Latina. Inter-American Development Bank, September 2021. http://dx.doi.org/10.18235/0003675.
Full textMeijer, William. Dark Field Proton Radiography Los Alamos LDRD Report. Office of Scientific and Technical Information (OSTI), March 2023. http://dx.doi.org/10.2172/1961360.
Full textKolski, Jeffrey S., Robert J. Macek, and Rodney C. McCrady. Orbit Response Matrix (ORM) Analysis in the Los Alamos Proton Storage Ring. Office of Scientific and Technical Information (OSTI), January 2011. http://dx.doi.org/10.2172/1009114.
Full textThiessen, H. A., F. Neri, K. Rust, and D. B. Redd. Multi-pulse extraction from Los Alamos Proton Storage Ring for radiographic applications. Office of Scientific and Technical Information (OSTI), August 1997. http://dx.doi.org/10.2172/521645.
Full textBarefoot, Susan F., Bonita A. Glatz, Nathan Gollop, and Thomas A. Hughes. Bacteriocin Markers for Propionibacteria Gene Transfer Systems. United States Department of Agriculture, June 2000. http://dx.doi.org/10.32747/2000.7573993.bard.
Full textAguerrevere, Gabriela, and Maria Victoria Fazio. 'E-lancing' en América Latina y el Caribe: ¿cómo conectar el talento digital con oportunidades globales? Inter-American Development Bank, August 2021. http://dx.doi.org/10.18235/0003590.
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