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Dissertations / Theses on the topic 'PROTEIN N'

Author: Grafiati

Published: 11 September 2023

Last updated: 31 July 2025

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1

Lundell, Sandra J. "Quantum Mechanical Studies of N-H···N Hydrogen Bonding in Acetamide Derivatives and Amino Acids." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7309.

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Proteins are made of vast chains of amino acids that twist and fold into intricate designs. These structures are held in place by networks of noncovalent interactions. One of these, the hydrogen bond, forms bridges between adjacent pieces of the protein chain and is one of the most important contributors to the shape and stability of proteins. Hydrogen bonds come in all shapes and sizes and a full understanding of these not only aids in our understanding of proteins in general but can bridge the gap to finding cures to many protein-related diseases, such as sickle-cell anemia. The primary aim

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2

Agah, Sayeh. "Parvalbumin stability and calcium affinity : the impact of the n-terminal domain /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?3164486.

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3

Huffman, Jennifer Elizabeth. "Genetic analysis of protein N-glycosylation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10038.

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The majority of human proteins are post-translationally modified by covalent addition of one or more complex oligosaccharides (glycans). Alterations in glycosylation processing are associated with numerous diseases and glycans are attracting increasing attention both as disease biomarkers and as targets for novel therapeutic approaches. Using a recently developed high performance liquid chromatography (HPLC) method for high-throughput glycan analysis, genome-wide association studies (GWAS) of 33 directly measured and 13 derived N-glycan features were performed in 3533 individuals from four Eur

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4

Lucas, Olivier. "Molecular and systemic functions of the vertebrate-specific TATA-binding protein N terminus." Diss., Montana State University, 2009. http://etd.lib.montana.edu/etd/2009/lucas/LucasO0509.pdf.

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5

Woollard, Geoffrey Robert Paget. "Redesign of the N-end rule protein ClpS for use in high-throughput N-end protein sequencing." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46377.

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Current protein sequencing methods include mass spectrometry and Edman degradation. We envision a novel high-throughput protein sequencing method using affinity adapters to recognize the N-terminal residue of a denatured peptide in an iterative process. This thesis takes a first step toward designing robust and selective affinity reagents. We outline our pipeline for designing selective protein adapters that recognize the N-terminal amino acid of a peptide independent of the following sequence. We based our design on a substrate recognition protein in the N-end rule pathway, ClpS. The bacteria

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6

Wood, Alison. "N-linked protein glycosylation in Helicobacter species." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nlinked-protein-glycosylation-in-helicobacter-species(ef97ffdd-aca4-40ff-b52b-7b8ca030bc82).html.

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N-linked protein glycosylation involves the transfer of a glycan onto an Asparagine residue (N) of a polypeptide chain. It is common in Eukaryotes and has recently been observed in Prokaryotes, most notably in Campylobacter jejuni. The C. jejuni N-linked glycosylation system is encoded on a single pgl gene locus that also functions when expressed in Escherichia coli. The key enzyme involved in N-linked protein glycosylation is encoded by the pglB gene and transfers lipid-linked glycan onto N residues of glycoproteins in the periplasm. It is clear from accumulating genome sequence data that pgl

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7

Karlsson, Gunilla Birgitta. "Effects of the imino sugar N-butyldeoxynojirimycin on protein N-linked glycosylation." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333246.

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8

Raggett, Elaine. "The structure and function of translocation domain of Colicin N." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285400.

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9

Murray, Anne Riché. "The functional significance of rhodopsin's N-linked glycosylation." Oklahoma City : [s.n.], 2009.

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10

Su, Wei. "Characterization of N-GAIP, a novel RGS protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0010/MQ40774.pdf.

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11

Zamiri, Maryam. "Synthesis of protein arginine N-methyltransferase 6 inhibitors." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43808.

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Protein arginine N-methyltransferases (PRMTs) are pertinent targets for drug discovery as their dysfunction is associated with a number of diseases such as cancers, cardiovascular diseases and viral pathogenesis. The precise role of PRMTs in the initiation, development, or progression of diseases is not known yet. Due to association of PRMT1 and 4 with transcriptional activation, the main focus of inhibitor discovery has been on these two enzymes. On the other hand, the goal of this study is to find a PRMT6 specific inhibitor. PRMT6 methylates DNA polymerase β, histones H3 and H4 and HIV pr

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12

Mackie, Brianna D. "Chemical Probes for Protein α-N-Terminal Methylation". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4880.

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While protein α-N-terminal methylation has been known for nearly four decades since it was first uncovered on bacteria ribosomal proteins L33, the function of this modification is still not entirely understood. Recent discoveries have demonstrated α-N-terminal methylation is essential to stabilize the interactions between regulator of chromosome condensation 1 (RCC1) and chromatin during mitosis, to localize and enhance the interaction of centromere proteins (CENPs) with chromatin, and to facilitate the recruitment of DNA damage-binding protein 2 (DDB2) to DNA damage foci. Identification of N-

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13

Eifan, Saleh A. "Functional analysis of the orthobunyavirus nucleocapsid (N) protein." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/542.

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14

Glover, William Broc. "N-beta-methylamino-L-alanine : a non-protein amino acid incorporated into protein." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50730.

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N-β-methylamino-L-alanine (BMAA) is a naturally-occurring toxin produced in cyanobacteria that has been linked to neurological degeneration. Efforts to study and quantify BMAA in the environment are hampered by two biologically-occurring isomers, N-(2- aminoethyl)glycine (AEG) and 2,4-diaminobutyric acid (DAB), that exist in very low concentrations in many sample matrices, indicating a need for improved analytical methods. The first objective of this thesis is to develop an accurate, precise and sensitive method for the analysis of BMAA and the isomers AEG and DAB that is applicable to a wide

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15

Sealey, Amy Lynn. "Loss of the murine TATA-binding protein N terminus leads to placental labyrinth defects but not maternal adaptive immune responses." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/sealey/SealeyA0507.pdf.

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16

Koch, Kerstin. "Statistical analysis of amino acid side chain flexibility for 1:n protein protein docking." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968919413.

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17

Jiménez, Flores Lizbeth Minerva. "The Role of Protein Kinase N in Gastric Cancer." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664078.

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Gastric cancer (GC) is one of the most common types of cancer in the Western World and accounts for over 700,000 deaths every year worldwide. The prognosis is dismal, with an average 5-year survival rate of less than 20%, mainly because of late diagnosis, due to the early stages are clinically silent. The cause of GC is multifactorial, as infectious agents, enviromental or/and genetic factors. Based on Lauren’s histologic classification, there are 2 types of GC: intestinal (IGC) and diffuse (DGC). Diffuse carcinoma cells lacks cohesion and invade tissues independently or in small clusters, is

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18

Lexis, Meike [Verfasser], and N. [Akademischer Betreuer] Willenbacher. "Rheology of Protein Foams / Meike Lexis. Betreuer: N. Willenbacher." Karlsruhe : KIT-Bibliothek, 2015. http://d-nb.info/1073939871/34.

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19

Pak, Laam. "Insights into a heteromeric protein arginine N-methyltransferase complex." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42123.

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Protein arginine N-methyltransferases (PRMTs) act in signaling pathways and gene expression by methylating arginine residues within target proteins. PRMT1 is responsible for most cellular arginine methylation activity and can work independently or in collaboration with other PRMTs. In this Ph.D. thesis I demonstrated an interaction between PRMT1 and -2 using co-immunoprecipitation and bimolecular fluorescence complementation (BiFC). As a result of this interaction, PRMT2 stimulated PRMT1 methyltransferase activity, affecting its apparent Vmax and Km values in vitro, and increasing the producti

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20

Ntwasa, Monde McMillan. "The studies of Drosophila Myristoyl-CoA : protein N-myristoyltransferase." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627451.

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21

Ikenaka, Yasuhiro. "Protein Engineering of N-Carbamyl-D-Amino Acid Amidohydrolase." Kyoto University, 1999. http://hdl.handle.net/2433/181917.

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22

Frost, Helen. "N-linked protein glycosylation in Campylobacter and Helicobacter species." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/nlinked-protein-glycosylation-in-campylobacter-and-helicobacter-species(ca49728c-1406-463f-bead-99d7cf336cb9).html.

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N-linked protein glycosylation is the enzymatic transfer of a carbohydrate glycan to an asparagine residue of a polypeptide, catalysed by an N-oligosaccharyl transferase(OTase). Bacterial N-glycosylation is best understood in the foodborne pathogen Campylobacter jejuni, in which a heptasaccharide glycan is built at cytoplasmic face of the inner membrane, flipped to the periplasm and transferred to a polypeptide enbloc. C. jejuni encodes each of the proteins required for the N-glycosylation pathway in a single genetic region, termed the pgl locus. Homologues of the gene encoding the C. jejuni O

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23

Liu, Yuxin. "Pctaire1 phosphorylates N-ethylmaleimide sensitive fusion protein and regulates exocytosis /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BICH%202006%20LIU.

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24

Fatkins, David G. "N(EPSILON)-THIOACETYL-LYSINE AS A MULTIFACETED TOOL FOR ENZYMATIC PROTEIN LYSINE N(EPSILON)-DEACETYLATION." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1185377018.

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25

Kam, Yuet Fong. "Regulation of c-jun n-terminal kinases by opioid receptors /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?BICH%202002%20KAM.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2002.<br>Includes bibliographical references (leaves 83-103). Also available in electronic version. Access restricted to campus users.

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26

Wright, Megan Holly. "Chemical tools for probing protein N-myristoylation in protozoan parasites." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/39376.

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Protein N -myristoylation is the attachment of a 14-carbon fatty acid, myristate, onto the N-terminal residue of specific proteins. This co - and post-translational modification is catalysed by myristoyl CoA:protein N -myristoyltransferase (NMT), an essential enzyme in eukaryotes. N -Myristoylated proteins have diverse roles, but typically localise to cellular membranes where many are thought to be involved in signalling or trafficking processes. NMT is a potential therapeutic target in diseases caused by parasitic protozoa, such as malaria, leishmaniasis and African sleeping sickness. N -Myri

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27

Brooke, Edward W. "Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis." Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:f13c3191-b098-4a85-84c3-90590b365d30.

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Tuberculosis is the world's largest cause of death from an infectious agent. Treatment is by an extended period of combination chemotherapy. Drug resistance is an increasing problem in tuberculosis therapy, particularly to the frontline anti-tubercular drug isoniazid (INH). Recombinant arylamine N-acetyltransferase (NAT) of Mycobacterium tuberculosis N-acetylates INH using the cofactor Acetyl Coenzyme A. NAT from M. tuberculosis is a polymorphic enzyme and also acetylates INH in vivo. Acetylated INH is inactive therapeutically against M. tuberculosis both in vivo and in vitro. The acetylation

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28

Anthony, Shelagh. "Analysis of mammalian protein arginine N-methyltransferases in the vasculature." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424909.

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29

Stroukova, Daria. "Recombinant expression and characterisation of the colicin N immunity protein." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3250.

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Some Escherichia coli express plasmid encoded toxins called colicins to eliminate ecological competitors. Colicins are a diverse group of toxins, usually divided into three groups: nucleases, pore-formers and peptidoglycan synthesis inhibitors. In addition, each colicinogenic plasmid codes for an immunity protein - a self-protection mechanism against its own toxin. Immunity proteins are highly specific to their cognate toxins but it is not clearly known how immunity proteins to pore-forming colicins achieve protection. This work focuses on the immunity protein for the smallest pore-forming col

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30

Caufield, J. Harry. "N-TERMINAL PROCESSING OF RIBOSOMAL PROTEIN L27 IN STAPHYLOCOCCUS AUREUS." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/361.

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The bacterial ribosome is essential to cell growth yet little is known about how its proteins attain their mature structures. Recent studies indicate that certain Staphlyococcus aureus bacteriophage protein sequences contain specific sites that may be cleaved by a non-bacteriophage enzyme (Poliakov et al. 2008). The phage cleavage site was found to bear sequence similarity to the N-terminus of S. aureus ribosomal protein L27. Previous studies in E. coli (Wower et al.1998; Maguire et al. 2005) found that L27 is situated adjacent to the ribosomal peptidyl transferase site, where it likely a

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31

Ottman, Michael J., Michael D. Sheedy, and Richard W. Ward. "Late Season N Application Method Effect on Grain Protein, 2016." College of Agriculture, University of Arizona (Tucson, AZ), 2016. http://hdl.handle.net/10150/625425.

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4 pp.<br>Nitrogen fertilizer is normally applied later in the season around flowering time to boost grain protein content. The purpose of this study is to determine if the grain protein boost provided by late N application is affected by method of application. A trial testing late season N application methods was conducted at the Maricopa Ag Center in the 2016 growing season. The crop was grown 211 lb N/acre in split applications until flowering when 35 lb N/acre was applied as UAN32 in the irrigation water (fertigation), as low biuret urea in a foliar application, or as urea granules compared

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32

VANTARAKI, CHRISTINA. "Counteraction of urea-induced protein denaturation by Trimethylamine N-oxide." Thesis, Uppsala universitet, Molekyl- och kondenserade materiens fysik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390487.

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A common consequence of protein denaturation is the loss of biological activity. Natural osmolytes such as Trimethylamine N-oxide (TMAO) contribute to protein folding, whereas other osmolytes such as urea act as an agent in the denaturation of proteins. Many studies have shown that denaturation of proteins could occur for certain concentrations of urea, however, this effect could be prevented with the presence of Trimethylamine N-oxide (TMAO) molecules. The aim of the present study is to find out the mechanism of TMAO as a protein stabilizer against urea. Firstly, Molecular Dynamics simulation

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33

Ventura, Marcello. "Prion protein: does N-terminal domain allow vesicular micronutrients uptake?" Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426867.

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Prion protein (PrPC) is a cell surface glycoprotein, anchored by the GPI to the cell membrane. It seems to be involved in some neurodegenerative diseases, but its physiological function is still undefined. Many cellular functions were proposed as PrPC roles, such as the modulation of several signal transduction pathways known to promote cellular survival and the protection against oxidative stress. Nevertheless, the main hypothesis on PrPC role is in copper homeostasis. Copper is an essential micronutrient (EMN) and all EMNs (vitamins and metals) are present in bodies and foods in micro

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34

Sanchez, Perez Maria Concepcion. "Study of the N-terminal domains of MDM2 and MDM4, and their potential for targeting by small-molecule drugs." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/8763.

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The MDM2 and MDM4 oncoproteins are both involved in regulating the tumour suppressor, p53. While the MDM2–p53 interface is structurally and biophysically well characterised, the MDM4-p53 interaction has only recently attracted researchers’ attentions. The goal of this project was to establish structural and chemical ground rules for the disruption of the interactions between the N-terminal domains of MDM2/4 and p53, which is an attractive anticancer strategy. In the current work, successful recombinant production and purification protocols for both the N-terminal domains of MDM2 (i.e. MDM2-N,

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35

McNeil, Gerard P. "Characterization of DNA-Protein Interactions at the NT/N Promoter: Proles for AP-1 and ATF Proteins." eScholarship@UMMS, 1996. http://escholarship.umassmed.edu/gsbs_diss/269.

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The focus of experiments presented in this dissertation is to determine how signals created by exposure to environmental stimuli are integrated at the level of transcription, resulting in the generation of specific patterns of gene expression. The model system used was expression of the neurotensinl neuromedin N (NT/N) neuropeptide gene in the neuroendocrine PC12 cell line. This gene is synergistically activated in PC12 cells in response to nerve growth factor, lithium, glucocorticoids, and activators of adenylate cyclase. Several cis-regulatory elements were identified within a 200 bp regulat

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36

Popham, Jennifer Mei-An. "A solid state NMR dipolar recoupling study of surface interactions of a N-terminal statherin fragment bound to hydroxyapatite /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8517.

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37

Salek, Reza M. "NMR studies of the heat shock protein 90 N-terminal domain." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446807/.

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The Hsp90 based chaperone is a ubiquitous protein-folding system in the cytoplasm of eukaryotes. Several signal transduction systems and cell cycling pathways utilise an interaction with Hsp90 as an essential component. The Hsp90 chaperone is an ATP dependent chaperone, which is active as a dimer. The N- terminal domain of Hsp90 itself has very weak ATPase activity and plays an essential role in the mechanism of dimerisation. This study attempts to elucidate the nucleotide binding effects on the Hsp90 N-terminal domain by NMR. Accomplishing backbone assignments of the apo- and AMP-PNP bound fo

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38

Patel, Avnish. "Studies of the intrinsically disordered N-terminus of murine prion protein." Thesis, University of Reading, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577771.

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Mammalian prion protein is able to cause a multitude of neurological maladies, most notably the transmissible spongiform echephalopathies. All are characterised by the misfolding of a non-pathogenic form the cellular protein Prpc to a misfolded aggregated isoform Prpscwhich leads to neurotoxicity and apoptosis characterised by brain spongiosis and amyloid plaque deposits. The exact molecular mechanisms of pathogenicity remain unknown for both the transmissible and inherited forms of disease. An artificially generated deletion of residues 105-125 of Prpc, encoding largely hydrophobic amino acid

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39

Wong, Shian Yea. "Identifying protein interaction partners of the Pitx2c N-terminus during embryogenesis." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123305.

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The vertebrate body is patterned asymmetrically along the left-right axis. Left-right patterning is required to establish correct asymmetric organ formation and positioning, and ultimately it is essential for normal physiological functioning. Misregulation in this process can lead to severe physiological defects in multiple organs, including the heart and gut. Pitx2c is a paired-like homeodomain transcription factor and is crucial for translating left-right signals into asymmetric morphogenesis. It is asymmetrically expressed in the left lateral plate mesoderm and continues to be expressed on

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40

Edwards, M. C. "Studies on (ADP-ribose)sub(n)-protein conjugates synthesised in vitro." Thesis, University of Reading, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371438.

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41

Mao, Yunfei. "Substrate Recognition and Mechanistic Studies of Protein N-Terminal Methyltransferase 1." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4414.

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The methylation at the α-N-terminal amines of proteins that start with a canonical motif X-P-K (X=A/P/S) has been a known modification for nearly four decades. In 2010, protein α-N-terminal methyltransferase 1 (NTMT1/NRMT1) was identified as the first enzyme responsible for this modification. NTMT2 was discovered as a second member belonging to this family, but it was reported as a mono-methylase. The identification of RCC1, retinoblastoma (Rb) protein, centromere protein-A/B (CENP-A/B), and DNA damaged-binding protein 2 (DDB2) as new NTMT1 substrates revealed NTMT1’s biological significance i

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42

Copin, Nane. "Catecholamine synthesising enzymes in the programming of hypertension by mild protein restriction during gestation." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268370.

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43

Orton, Christopher R. "Analysis of Protein Adduction Kinetics and the Effects of Protein Adduction on C-Jun N-Terminal Kinase Signaling." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194247.

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Defining the mechanics and consequences of protein adduction is crucial to understanding the toxicity of reactive electrophiles. Application of tandem mass spectrometry and data analysis algorithms enables detection and mapping of chemical adducts at the level of amino acid sequence. Nevertheless, detection of adducts does not indicate relative reactivity of different sites. In this dissertation I describe a method to measure the kinetics of competing adduction reactions at different sites on the same protein using quantitative mass spectrometry. Adducts are formed by electrophiles at Cys-

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44

Watson, Joanna. "Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/268520.

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Cdc42 is a member of the Rho family of small GTPases, which, together with its homologues RhoA and Rac1, controls a multitude of cellular functions via the actin cytoskeleton. Cdc42 exerts its effects on the cytoskeleton via effector proteins of the Wiskott-Aldrich Syndrome (WASP) family and the Transducer of Cdc42-dependent Actin assembly (TOCA) family. The WASP family and their activation by Cdc42 have been thoroughly studied in vitro and are well understood. Conversely, understanding of the TOCA family remains limited by a lack of biochemical, biophysical and structural insight. An investig

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45

Cain, Joel Aaron. "Evaluating the Relationship Between N-Glycosylation and Protein Stability in Campylobacter jejuni." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25679.

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The major enteric pathogen Campylobacter jejuni was the first prokaryote demonstrated to perform N-linked protein glycosylation. Although protein post-translational modifications involving glycan attachment to proteins are strongly associated with virulence, the mechanisms and functions of N-glycosylation remains to be determined. This thesis aimed to address some of the outstanding questions regarding the role of N-glycosylation in C. jejuni. Through application of quantitative proteomics we assessed the global effect of N-glycosylation to establish a causal relationship between the proteo

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46

Schulz, Benjamin Luke. "Analysis and mechanisms of site-specific N-linked protein glycosylation by oligosaccharyltransferase /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17559.

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47

Kotecha, Suhas Ashok. "G-protein coupled receptor modulation of N-methyl-D-aspartate channel activity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63766.pdf.

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48

Yadao, Franeli M. (Franeli Marie). "Physical interaction between human b-N-acetylhexosaminidase A and its activator protein." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24049.

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GM$ sb2$ ganglioside hydrolysis requires the formation of a ternary complex consisting of substrate, enzyme ($ beta$-N-acetylhexosaminidase A = Hex A), and the GM$ sb2$ activator protein. In order to study the interaction between Hex A and GM$ sb2$ activator, the human GM$ sb2$ activator cDNA was cloned into the p-FLAG vector. The fusion protein (FLAG-AP) was expressed in E. coli, and purified to homogeneity using immunoaffinity chromatography.<br>A retardation assay was designed using the immunoaffinity column to detect transient interactions between FLAG-AP and Hex A. Hex A and Hex S are ret

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49

Wang, Jian, and 王健. "Identification and characterization of N-terminal kinase like protein in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47036370.

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50

Bratzel, Graham Hayden. "Sequence-structure correlations in the MaSp1 protein of N. clavipes dragline silk." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67610.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 77-86).<br>Silk is a hierarchically structured protein fiber with exceptional tensile strength and extensibility, making it one of the toughest and most versatile biocompatible materials. While experimental studies have shown that the molecular structure of silk has a direct influence on the stiffness, toughness, and failure strength of silk, few molecular-level analyses of the nanostructure of silk assemblies, in parti

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