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1

Jones, Susan. "Protein-protein interactions." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338952.

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2

Cooper, Simon T. "PAX6 protein-protein interactions." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/29070.

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The gene <i>PAX6</i> is located on chromosome 11 (11p13) and encodes a transcription factor (PAX6) that is expressed early in development. The PAX6 protein is expressed in the developing eye, regions of the brain, central nervous system (CNS), nasal epithelium and pancreas. PAX6 is best known for its role eye development with heterozygous mutations causing congenital ocular malformations. However, it must be remembered that PAX6 has multiple functions in the brain including specification of neuronal subtypes and axon guidance. There is growing understanding of the role of PAX6 as a transcripti
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3

Braute, Petter, and Jorg Eliassen Rødsjø. "Protein function prediction using annotated protein-protein interaction networks." Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2005. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-9177.

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4

Govers-Riemslag, Josepha Wilhelmina Philomena. "Protein-protein and protein-membrane interactions in prothrombin activation." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=6949.

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5

Lendel, Christofer. "Molecular principles of protein stability and protein-protein interactions." Doctoral thesis, Stockholm, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-480.

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6

Kneissl, Sabine. "Photocontrol of protein-protein and protein-nucleic acid interactions." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/54835/.

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Proteins often depend on a-helices for binding to other biomacromolecules. Reversible control of a-helix stability was accomplished in previous studies by incorporating a photoisomerisable azobenzene cross-linker into peptides, subsequently enabling the optical control of DNA-protein interactions. This approach was extended in this study to include protein-protein and protein-RNA interactions. One of the primary regulatory components in apoptosis signalling is the antiapoptotic protein Bcl-xL which interacts with the a-helical BH3 domain of the Bak protein. The Rev/RRE interaction is crucially
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7

Moont, Gidon. "Computational modelling of protein/protein and protein/DNA docking." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445703/.

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The docking problem is to start with unbound conformations for the components of a complex, and computationally model a near-native structure for the complex. This thesis describes work in developing computer programs to tackle both protein/protein and protein/DNA docking. Empirical pair potential functions are generated from datasets of residue/residue interactions. A scoring function was parameterised and then used to screen possible complexes, generated by the global search computer algorithm FTDOCK using shape complementarity and electrostatics, for 9 systems. A correct docking (RMSD < 2.5
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8

Chen, Dan. "Regulation of protein kinase C by protein-protein interactions /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112821.

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9

Ginn, C. L. "Protein PEGylation on protein folding." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1403227/.

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E.coli is one of the most widely utilised hosts for protein expression due to its rapid growth, low production costs and high product yields. Often proteins are deposited as insoluble inclusion bodies that later require refolding to achieve biological activity. As a result of misfolding and aggregation for many proteins refolding is the yield limiting step in their production. Relevant therapeutic proteins obtained from E.coli include the α-helical barrel proteins (e.g. interferon-α2). Many proteins derived from E.coli are further modified after refolding by the covalent conjugation of poly(et
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10

McDowall, Mark. "Human protein-protein interaction prediction." Thesis, University of Dundee, 2011. https://discovery.dundee.ac.uk/en/studentTheses/697e465a-edbd-41d2-acda-5910a49e4157.

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Protein-protein interactions are essential for the survival of all living cells, allowing for processes such as cell signalling, metabolism and cell division to occur. Yet in humans there are only &gt;38k annotated interactions of an interactome estimated to range between 150k to 600k interactions and out of a potential 300M protein pairs.Experimental methods to define the human interactome generate high quality results, but are expensive and slow. Computational methods play an important role to fill the gap.To further this goal, the prediction of human protein-protein interactions was investi
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11

Ospina, Forero Luis Eduardo. "Modelling protein-protein interaction networks." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:c5150074-e160-4c59-8c23-f8804ae3dd2e.

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Proteins, the main motors of the cell, are in charge of performing a diverse array of biological functions. They rarely perform those functions alone, but generally work as groups of proteins that through a complex array of interactions perform a single biological function. These complex interactions between different proteins are often analysed via network theory, where a protein-protein interaction (PPI) network is created considering each protein as a node and each of their interactions as edges. Different approaches from the perspective of network analysis have been proposed to describe, a
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12

Herrington-Symes, A. P. "Protein-protein conjugation using interferon." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464509/.

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Therapeutic proteins are often potent and have rapid onsets of action. Unfortunately protein-based medicines can be immunogenic and have short half-lives. The circulation half-life of many proteins has been improved by the covalent conjugation of poly(ethylene)glycol (PEG) to the protein. For example, PEGylated interferon-2 (PEGASYS® and PEG-INTRON®) has become a first line treatment for hepatitis C. The aim of this thesis was to examine the possibility of using a homobifunctional PEG reagent to make protein dimers. Our group has developed PEGylation reagents that undergo conjugation by bis-a
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13

Schnee, Margit. "Protein fragment complementation assay for studying viral protein-protein interactions." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-65582.

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14

Ruan, Peiying. "Computational Methods for Analyzing Protein Complexes and Protein-Protein Interactions." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199433.

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15

Stevenson, Calum. "Database mining studies on protein-peptide and protein-protein interactions." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7644.

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A major area of interest is the identification of proteins that play a role in hormone dependent cancers and in collaboration with the MRC Centre for Reproductive Health we studied the gonadotropin releasing hormone receptor (GnRH-R). Other targets described in the thesis are the SH3 domain of PSD-95 and the protein BLyS. In order to identify potential inhibitory small molecules we have used a variety of computational data base mining approaches as well as using and developing experimental binding assays. It has become increasingly challenging to evaluate the most representative drug like smal
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16

Chiang, Angela Hsieh Fu-hung. "Protein-protein interaction of soy protein isolate from extrusion processing." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5099.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on May 11, 2009) Thesis advisor: Fu-Hung Hsieh. Includes bibliographical references.
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17

Cao, Zehui. "Designer oligonucleotides for probing dna-protein and protein-protein interactions." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008333.

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18

Chen, Kai. "Use of green fluorescent protein for the analysis of protein-protein and protein-DNA interactions." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4886.

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Restriction modification (RM) systems play a crucial role in preventing the entry of foreign DNA into the bacterial cell. The best studied Type I RM system is EcoKI from Escherichia coli K12. Both bacteriophage and conjugative plasmids have developed a variety of strategies to circumvent the host RM system. One such strategy involves the production of antirestriction proteins that mimic a short segment of DNA and efficiently inhibit the RM system. The main aim of this project was to analyse the interaction of EcoKI and its cognate methylase (MTase) with the T7 antirestriction protein, known as
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19

Chen, Huiling Zhou Huan Xiang Ferrone Frank A. "Prediction of protein structures and protein-protein interactions : a bioinformatics approach /." Philadelphia, Pa. : Drexel University, 2005. http://dspace.library.drexel.edu/handle/1860/481.

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20

Kulis, Michael D. "Islet neogenesis associated protein-related protein from gene to folded protein /." Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-01112006-195113/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2006.<br>Shuker, Suzanne, Committee Chair ; Doyle, Donald, Committee Member ; Orville, Allen, Committee Member ; Barry, Bridgette, Committee Member ; McCarty, Nael, Committee Member.
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21

Kulis, Michael D. Jr. "Islet Neogenesis Associated Protein-Related Protein: From Gene to Folded Protein." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/10436.

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Type 1 diabetes is the direct result of an autoimmune attack on the pancreatic islet cells. The islets contain b cells, which are the only type of cell capable of supplying insulin in the human body. The destruction of these cells leaves the diabetic to rely on exogenous insulin to maintain a normal blood sugar level. Insulin therapy allows the diabetic to deal with the symptoms of the disease, but does nothing for the underlying condition. In order to truly cure the disease, the strategy is to replenish the b cells in the diabetic. Islet neogenesis associated protein (INGAP) has been sho
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22

Worthington, Andrew Schuyler. "Chemoenzymatic investigations of protein-protein interactions in carrier protein-mediated biosynthesis." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3338769.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed January 9, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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23

Mohr, Andrea. "Protein-Protein-Interaktionen des G-CSFR." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960605398.

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24

Xia, Zebin. "Peptidomimetics to mimic protein-protein interactions." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/2239.

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Quenched Molecular Dynamics (QMD) used to explore molecular conformations was developed to operate in Insight II platform for two simulation engines: CHARMm and Discover. Two scripts and procedures were written for molecular minimization, dynamics, minimization of each of several hundred conformers, and cut off. Experience with Insight II/Discover versus Quanta/CHARMm, and between Insight II/CHARMm versus Quanta/CHARMm has taught that the forcefield is the key factor in QMD studies. Protein A has been used for the purification of commercial antibodies, but it is expensive. Seven peptidomimeti
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25

Bateman, Katherine Sophie. "Structural studies of protein, protein interactions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/NQ46804.pdf.

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26

Laidlaw, Stephen Mark. "Protein-protein interactions of fowlpox virus." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424671.

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27

Bougouffa, Salim. "Empirical modelling of protein-protein interactions." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529241.

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28

Robinson, Ross Alexander. "Structural biology of protein - protein interactions." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504517.

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29

Taylor, M. J. "Protein engineering of staphylococcal protein A." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373965.

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30

Gill, Katrina Louise. "Protein-protein interactions in membrane proteins." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400016.

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31

Hubbard, Simon Jeremy. "Analysis of protein-protein molecular recognition." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360151.

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32

Richter, Carsten Detlev. "Protein-protein interactions in modular megasynthases." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612738.

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33

Moal, I. H. "Predicting and characterising protein-protein complexes." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1333249/.

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Macromolecular interactions play a key role in all life processes. The construction and annotation of protein interaction networks is pivotal for the understanding of these processes, and how their perturbation leads to disease. However the extent of the human interactome and the limitations of the experimental techniques which can be brought to bear upon it necessitate theoretical approaches. Presented here are computational investigations into the interactions between biological macromolecules, focusing on the structural prediction of interactions, docking, and their kinetic and thermodynami
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34

Agius, R. "Understanding stability of protein-protein complexes." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1462393/.

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For all living organisms, macromolecular interactions facilitate most of their natural functions. Alterations to macromolecular structures through mutations, can affect the stability of their interactions, which may lead to unfavourable phenotypes and disease. Presented here, are a number of computational methods aimed at uncovering the principles behind complex stability - as described by binding affinity and dissociation rate constants. Several factors are known to govern the stability of protein-protein interactions, however, no one factor dominates, and it is the synergistic effect of a nu
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35

Sammond, Deanne Wallander Kuhlman Brian A. "Computational redesign of protein-protein interactions." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1822.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics Program in Molecular and Cellular Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine.
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36

Marín, López Manuel Alejandro 1987. "On the development of computational tools for the study of protein-protein interactions and protein-protein binding." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/565599.

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Proteins are involved in almost all cell processes, with physical interaction between them being key to their function and dictated by its 3D structure. Hence, the study of protein-protein interactions and protein-protein binding is crucial to fully understand biological systems. In this thesis, we present V-D2OCK, a fast and accurate data-driven docking tool for high throughput prediction of the structure of protein complexes. We have also studied the conformational space of potential encounter complexes by means of non-specific decoys obtained by docking in order to develop BADock, an accura
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37

Rupp, Bernd. "Molecular-Modelling-Untersuchungen zu Wechselwirkungen in Protein-Protein- und Protein-Ligand-Komplexen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971538522.

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38

Chin-Sang, Ian D. "Protein-protein interactions and protein phosphatase activity in Caenorhabditis elegans sex determination." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35125.pdf.

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39

Albertoni, Barbara [Verfasser]. "Biophysical analysis of protein-protein and protein-small molecule interactions / Barbara Albertoni." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1044846909/34.

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40

Cai, Bingjing. "Machine learning approaches for extracting protein complexes from protein-protein interaction networks." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603536.

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Recent advances in molecular biology have led to the accumulation of large amounts of data on Protein-Protein Interaction (PPI) networks in different species, such as yeast and humans. Due to the inherent complexity, analysing such volumes of data to extract knowledge, such as protein complexes or regulatory pathways, represents not only an enormous challenge but also a great opportunity. This Thesis explores the application of machine learning approaches to detecting protein complexes from PPI networks obtained by Tandem Affinity Purification/Mass Spectrometry (TAP-MS) experiments. TAP-MS PPI
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41

Bennett, Matthew Stuart. "Crystallography of biomolecular complexes, revealing protein-nucleoside, protein-protein acid-drug interactions." Thesis, King's College London (University of London), 2002. https://kclpure.kcl.ac.uk/portal/en/theses/crystallography-of-biomolecular-complexes-revealing-proteinnucleoside-proteinprotein-aciddrug-interactions(4a85b5cd-8a9a-4969-bee3-95fbe46e4257).html.

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42

Fernández, Suárez Marta. "New reporters of protein trafficking and protein-protein interactions in live cells." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44678.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.<br>Vita.<br>Includes bibliographical references.<br>Here, we describe our attempts to harness the exquisite specificity of natural protein and RNA enzymes to develop improved methods to study protein localization and protein-protein interactions in live cells. We first attempted to detect endogenous protein-protein interactions (PPIs) in live cells by means of a ribozyme complementation assay, but we found that the strategy was limited by the interaction affinity constraints and by low ribozyme activity in cells.
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43

Gwynne, Peter John. "Protein-protein interactions of the cold shock protein CspE of Salmonella typhimurium." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/10048.

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Despite their name, a number of the cold shock proteins are expressed during normal growth, and not just during cold shock, in several species. The function of these constitutively expressed CspA paralogues is unclear. In Salmonella Typhimurium (a major worldwide cause of gastrointestinal disease) they have been linked to various stress responses and the establishment of virulence. Study of the cold shock proteins as gene regulators is therefore of great interest, and they also have potential as targets for antimicrobial development. CspE in Salmonella Typhimurium is constitutively expressed d
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44

Yang, Hui. "Theoretical Studies of Molecular Recognition in Protein-Ligand and Protein-Protein Complexes." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1282339026.

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45

Park, Changmoon Goddard William A. "Protein design and simulation Part I. Protein design. Part II. Protein simulation /." Diss., Pasadena, Calif. : California Institute of Technology, 1993. http://resolver.caltech.edu/CaltechTHESIS:11112009-114142428.

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Thesis (Ph. D.)--California Institute of Technology, 1993. UM #93-25,374.<br>Advisor names found in the Acknowledgements pages of the thesis. Title from home page. Viewed 01/15/2010. Includes bibliographical references.
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46

Stains, Cliff. "Methods for the Detection of Protein-Nucleic Acid and Protein-Protein Interactions." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194834.

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We describe the first general approach for the DNA templated reassembly of proteins, which we term SEquence-Enabled Reassembly or SEER. SEER makes use of dissected signaling domains which are each attached to separate, sequence specific DNA-binding proteins. Described herein is an embodiment of SEER in which DNA catalyzes the reassembly of the green fluorescent protein which leads to a direct fluorescence readout of the corresponding DNA sequence. This strategy has also been extended to the first direct method for the site specific detection of DNA methylation. This mCpG-SEER system is cap
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47

Boscolo, Cappon Jona <1988&gt. "DETECTIVE OVERLAPPING PROTEIN COMPLEXES IN PROTEIN-PROTEIN INTERACTION NETWORK USING DOMINANT SETS." Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/2871.

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48

García-García, Javier 1982. "Protein-protein interaction network : management of databases and its applications on the computational study of protein-protein interactions." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/286512.

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The use of protein-protein interaction networks has become crucial due to the emergence of systems biology. The completeness and quality of networks, crucial to understand the biochemical mechanisms underlying a system such as a cell, are still challenging the scientific community. This thesis focuses on the data completeness challenge by the development of flexible tools for biological data management. It presents a database framework, BIANA, in which the integrated access to several information sources tackles this problem by unraveling hidden biological associations. BIANA is used to develo
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49

Wu, Feihong. "Protein-protein interface database, analysis and prediction /." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3379186.

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50

Yu, Chao. "Matrix bound peptides modeling protein-protein interactions." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969927932.

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