Relevant bibliographies by topics / Protein Receptor

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Protein Receptor'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Protein Receptor"

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Tibrewal, Richa, Reynoldly Kharsyntiew, Farida Dawood, and Archana Sharma. "A REVIEW ON G-PROTEIN COUPLED RECEPTOR." International Journal of Current Pharmaceutical Review and Research 13, no. 04 (2021): 01–09. https://doi.org/10.5281/zenodo.12664417.

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AbstractG protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domainreceptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linkedreceptors (GPLR), constitute a large protein family of receptors that detect molecules outsidethe cell and activate internal signal transduction pathways and, ultimately, cellular responses.Coupling with G proteins, they are called seven-transmembrane receptors because they passthrough the cell membrane seven times. G protein–coupled receptors are found only ineukaryotes, including yeast, choanof
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Prado, M. A., B. Evans-Bain, and I. M. Dickerson. "Receptor component protein (RCP): a member of a multi-protein complex required for G-protein-coupled signal transduction." Biochemical Society Transactions 30, no. 4 (2002): 460–64. http://dx.doi.org/10.1042/bst0300460.

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The calcitonin-gene-related peptide (CGRP) receptor component protein (RCP) is a 148-amino-acid intracellular protein that is required for G-protein-coupled signal transduction at receptors for the neuropeptide CGRP. RCP works in conjunction with two other proteins to constitute a functional CGRP receptor: calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1).CRLR has the stereotypical seven-transmembrane topology of a G-protein-coupled receptor; it requires RAMP1 for trafficking to the cell surface and for ligand specificity, and requires RCP for coupling
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Zeng, Fu-Yue. "Signaling by G Protein-Coupled Receptors." Electronic Journal of Pathology and Histology 6, no. 1 (2000): 13. https://doi.org/10.3233/eph-2000-6_1_13.

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G protein-coupled receptors represent one of the largest families of cell surface receptors in nature. These receptors play fundamental roles in diverse physiological processes such as neurotransmission, cellular metabolism, cell differentiation and growth as well as immune response. In response to extracellular ligands, G protein-coupled receptors specifically interact with heterotrimeric G proteins that can then activate or inhibit effector enzymes, ultimately leading to the physiological response. Biochemical and mutational studies have revealed the molecular mechanisms of ligand-receptor i
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Santiago, Luis, and Ravinder Abrol. "Understanding G Protein Selectivity of Muscarinic Acetylcholine Receptors Using Computational Methods." International Journal of Molecular Sciences 20, no. 21 (2019): 5290. http://dx.doi.org/10.3390/ijms20215290.

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The neurotransmitter molecule acetylcholine is capable of activating five muscarinic acetylcholine receptors, M1 through M5, which belong to the superfamily of G-protein-coupled receptors (GPCRs). These five receptors share high sequence and structure homology; however, the M1, M3, and M5 receptor subtypes signal preferentially through the Gαq/11 subset of G proteins, whereas the M2 and M4 receptor subtypes signal through the Gαi/o subset of G proteins, resulting in very different intracellular signaling cascades and physiological effects. The structural basis for this innate ability of the M1
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Dosil, Mercedes, Kimberly A. Schandel, Ekta Gupta, Duane D. Jenness та James B. Konopka. "The C Terminus of the Saccharomyces cerevisiaeα-Factor Receptor Contributes to the Formation of Preactivation Complexes with Its Cognate G Protein". Molecular and Cellular Biology 20, № 14 (2000): 5321–29. http://dx.doi.org/10.1128/mcb.20.14.5321-5329.2000.

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ABSTRACT Binding of the α-factor pheromone to its G-protein-coupled receptor (encoded by STE2) activates the mating pathway inMATa yeast cells. To investigate whether specific interactions between the receptor and the G protein occur prior to ligand binding, we analyzed dominant-negative mutant receptors that compete with wild-type receptors for G proteins, and we analyzed the ability of receptors to suppress the constitutive signaling activity of mutant Gα subunits in an α-factor-independent manner. Although the amino acid substitution L236H in the third intracellular loop of the receptor imp
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Ferguson, SSG, J. Zhang, LS Barak, and MG Caron. "Pleiotropic Role for GRKs and b-Arrestins in Receptor Regulation." Physiology 12, no. 4 (1997): 145–52. http://dx.doi.org/10.1152/physiologyonline.1997.12.4.145.

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G protein-coupled receptor kinases and arrestin proteins are well-characterized mediators of agonist-dependent G protein-coupled receptor desensitization. These proteins are now shown to play a dual role in receptor regulation by mediating both receptor uncoupling and sequestration, a process important for receptor resensitization. b-Arrestins bound to phosporylated b2-adrenergic and angiotensin II type 1A receptors act as intracellular trafficking molecules specifically targeting these receptors for dynamin-dependent clathrin-coated vesicle-mediated sequestration.
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Brydon, Lena, Florian Roka, Laurence Petit, et al. "Dual Signaling of Human Mel1a Melatonin Receptors via Gi2, Gi3, and Gq/11 Proteins." Molecular Endocrinology 13, no. 12 (1999): 2025–38. http://dx.doi.org/10.1210/mend.13.12.0390.

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Abstract Mel 1a melatonin receptors belong to the superfamily of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. So far, interest in Mel 1a receptor signaling has focused mainly on the modulation of the adenylyl cyclase pathway via pertussis toxin (PTX)-sensitive G proteins. To further investigate signaling of the human Mel 1a receptor, we have developed an antibody directed against the C terminus of this receptor. This antibody detected the Mel 1a receptor as a protein with an apparent molecular mass of approximately 60 kDa in immunoblots after separation by SDS-P
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Oldham, William M., and Heidi E. Hamm. "Structural basis of function in heterotrimeric G proteins." Quarterly Reviews of Biophysics 39, no. 2 (2006): 117–66. http://dx.doi.org/10.1017/s0033583506004306.

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1. Introduction 22. Heterotrimeric G-protein structure 32.1. G-protein α subunit 32.2. G-protein βγ dimer 82.3. Unique role of Gβ5 in complexes with RGS proteins 92.4. Heterotrimer structure 102.5. Lipid modifications direct membrane association 113. Receptor–G protein complex 113.1. Low affinity interactions between inactive receptors (R) and G proteins 113.2. Receptor activation exposes the high-affinity G-protein binding site 123.3. Receptor–G protein interface 143.4. Structural determinants of receptor–G protein specificity 153.5. Models of the receptor–G protein complex 173.6. Sequential
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Milligan, G., H. Murdoch, E. Kellett, J. H. White, and G. J. Feng. "Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation." Biochemical Society Transactions 32, no. 5 (2004): 878–80. http://dx.doi.org/10.1042/bst0320878.

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A substantial number of G-protein-coupled receptor-interacting proteins have been identified initially by the use of yeast two-hybrid screens. Using the C-terminal tail of both opioid receptors and the melanin concentrating hormone receptor-1 as bait, the actin and intermediate filament-binding protein periplakin was isolated. In each case, the site of interaction is within helix VIII of the receptor and periplakin limits agonist-mediated G-protein activation potentially by competing with G-protein for this region of the receptor.
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Okashah, Najeah, Shane C. Wright, Kouki Kawakami, et al. "Agonist-induced formation of unproductive receptor-G12complexes." Proceedings of the National Academy of Sciences 117, no. 35 (2020): 21723–30. http://dx.doi.org/10.1073/pnas.2003787117.

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G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes G protein activation and, conversely, that activated GPCRs do not interact with G proteins that they do not activate. Here we show that GPCRs can form agonist-dependent complexes with G proteins that they do not activate. Using cell-based bioluminescence resonance energy transfer (BRET) and luminescence assays we find that vasopressin V2receptors (V2R) as
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Dissertations / Theses on the topic "Protein Receptor"

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Magno, Aaron. "Proteins associated with the intracellular signalling tail of the calcium-sensing receptor and their impact on receptor function." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0028.

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[Truncated abstract] The calcium-sensing receptor (CaR) is a G protein-coupled receptor that can respond to changes in extracellular calcium and plays an integral role in calcium homeostasis. Later studies revealed that the CaR was stimulated by not just calcium, but a diverse range of stimuli and that activation of the receptor regulated a host of different biological processes. The CaR is linked to these cellular responses via the various signalling pathways initiated by the receptor. Recent yeast two-hybrid studies have identified a number of accessory proteins that, through their interacti
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Nguyen, Giang Huong. "A functional analysis of the human LPA₁G protein coupled receptor." Thesis, Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131304/unrestricted/nguyen%5Fgiang%5Fh%5F200405%5Fms.pdf.

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Davidson, L. "Protein-protein interactions in GnRH receptor signalling." Thesis, University of Edinburgh, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649167.

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Human embryonic kidney (HEK) 293 cells, stably expressing the rat GnRH receptor were used to investigate the mechanism of ERK activation by GnRH.  ERK activation was found to be dependent on cell adhesion to the extracellular matrix, and required an intact actin cytoskeleton. Through the use of specific pharmacological inhibitors and expression of dominant negative cDNA constructs, ERK activation was found to be mediated by the Rho family GTPase Rac1, and the non-receptor tyrosine kinases Src and focal adhesion kinase (FAK). FAK was found to function as a tyrosine phosphorylated scaffold upon
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Plouffe, Bianca. "Comprehensive Model of G Protein-coupled Receptor Regulation by Protein Kinase C: Insight from Dopamine D1 and D5 Receptor Studies." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20577.

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Dopamine receptors belong to the G protein-coupled receptor (GPCR) superfamily and are classified into two families: D1-like (D1R and D5R) and D2-like (D2R, D3R and D4R), based on their ability to stimulate or inhibit adenylyl cyclase (AC). Classically, GPCRs (including D2R and D3R) are desensitized by the activation of the serine/threonine protein kinase C (PKC) upon phorbol-12-myristate-13-acetate (PMA) treatment. Previous studies demonstrate that while human D5R (hD5R) is also strongly desensitized upon PMA treatment, the human D1R (hD1R) undergo a robust PMA-induced sensitization. The aim
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Tchetchelnitski, V. "Regulation of neurotrophin receptors by receptor-type protein tyrosine phosphatases." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1310477/.

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Reversible protein phosphorylation plays a key role in cell signalling during neural development and thus controls cell proliferation, survival, differentiation and function. Kinases and their counter-partners the phosphatases tightly regulate protein phosphorylation. In the developing nervous system the neurotrophin receptor family of protein tyrosine kinases (TrkA, B and C) are major players in this signalling network during normal neuron development and also in several diseases such as neuropathies, degenerative disorders and cancers. Recently, receptor-type protein tyrosine phosphatases (R
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Borroto, Escuela Dasiel Oscar. "Human M3 muscarinic acetylcholine receptor protein-protein interactions: roles in receptor signaling and regualation." Doctoral thesis, Universitat Politècnica de Catalunya, 2008. http://hdl.handle.net/10803/22678.

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Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate various functions in the central and peripheral nervous systems. These include modulation of exocrine glandular secretion, vasodilatation and smooth muscle contraction, cell proliferation or survival, neural development and synaptic plasticity. mAChRs are activated by both endogenously produced acetylcholine and exogenously administered muscarinic compounds. Pharmacological, anatomical and molecular studies have demonstrated the existence of five muscarinic receptor subtypes, denoted as muscarinic M1, M2, M3, M4 and M5, whi
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Dhananjayan, Sarath Chandran. "Receptor Selective Coactivators: Characterization of a Novel Protein-Protein Interaction Module in Steroid Hormone Receptor Signaling." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/67.

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WW-domain binding protein-2 (WBP-2) was cloned as an E6-associated protein (E6-AP) interacting protein and its role in steroid hormone receptor (SHR) function was investigated. We show that WBP-2 differs from other SHR coactivators, as it specifically enhanced the transactivation functions of progesterone receptor (PR) and estrogen receptor (ER alpha), whereas it had no significant effect on the androgen receptor, glucocorticoid receptor or the activation functions of p53 or VP-16. We also demonstrated that, like other well characterized coactivators, WBP-2 contains an intrinsic activation dom
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McAinsh, Kristina. "Investigations of GABAA receptor phosphorylation and receptor-protein interactions." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445690/.

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GABAA receptors mediate the majority of fast synaptic inhibition in the adult mammalian brain, and play a critical role in controlling neuronal excitability during development. The functional properties and stability of cell-surface GABAA receptors are key determinants of the efficacy of GABAergic neurotransmission. I therefore employed a broad spectrum of biochemical, and cell and molecular biological techniques to identify molecular interactions that may be involved in regulating the activity and number of GABAA receptors at the neuronal surface. In this thesis, I identified a novel interact
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King, Martin John. "Insulin receptor phosphotyrosyl protein phosphates." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241611.

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Sallander, Eva Jessica. "The mechanism of G protein coupled receptor activation: the serotonin receptors." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/77901.

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Una de las principales cuestiones en farmacología molecular de los GPCR es entender los mecanismos estructurales de las siete hélices transmembrana (TM) que se producen para estabilizar ya sea Rg o los diferentes estados R*. Para entender el mecanismo que cambia el equilibrio del conjunto a un estado activo R* se construyeron tres de los receptores de la serotonina (5-HT4, 5-HT6, y 5 HT7) sobre la base de su información más reciente de cristalografía de rayos X. Dando lugar a dos modelos de cada receptor: una inactiva y otra activa. Los modelos, mejorados y evaluados con la ayuda de datos fa
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Books on the topic "Protein Receptor"

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R, George Susan, and O'Dowd Brian Francis 1950-, eds. G protein-coupled receptor-protein interactions. Wiley-Liss, 2005.

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Herrick-Davis, Katharine, Graeme Milligan, and Giuseppe Di Giovanni, eds. G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8.

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Stevens, Craig W., ed. G Protein-Coupled Receptor Genetics. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-779-2.

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Gurevich, Vsevolod V., Eugenia V. Gurevich, and John J. G. Tesmer, eds. G Protein-Coupled Receptor Kinases. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3798-1.

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Tiberi, Mario, ed. G Protein-Coupled Receptor Signaling. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9121-1.

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Martins, Sofia Aires M., and Duarte Miguel F. Prazeres, eds. G Protein-Coupled Receptor Screening Assays. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1221-7.

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Prazeres, Duarte Miguel F., and Sofia Aires M. Martins, eds. G Protein-Coupled Receptor Screening Assays. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2336-6.

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Germano, Serena. Receptor tyrosine kinases: Methods and protocols. Humana Press, 2015.

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Running, Mark P., ed. G Protein-Coupled Receptor Signaling in Plants. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-532-3.

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Prazeres, Duarte Miguel F., and Sofia Aires M. Martins. G protein-coupled receptor screening assays: Methods and protocols. Humana Press, 2015.

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Book chapters on the topic "Protein Receptor"

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Greengard, Paul. "Receptor-Receptor Interactions Mediated by Protein Phosphorylation." In Receptor-Receptor Interactions. Palgrave Macmillan UK, 1987. http://dx.doi.org/10.1007/978-1-349-08949-9_36.

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Greengard, Paul. "Receptor-Receptor Interactions Mediated by Protein Phosphorylation." In Receptor-Receptor Interactions. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5415-4_36.

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Kato, Michimasa, Masataka Okuno, and Yasutoshi Muto. "Retinoic Acid-Binding Protein." In Receptor Purification. Humana Press, 1990. http://dx.doi.org/10.1007/978-1-4612-0477-0_16.

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den Hertog, Jeroen. "Receptor protein tyrosine phosphatases." In Protein Phosphatases. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-540-40035-6_13.

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Thiriet, Marc. "Receptor Protein Kinases." In Signaling at the Cell Surface in the Circulatory and Ventilatory Systems. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1991-4_8.

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Jakobs, Karl H., Peter Gierschik, Rüdiger Grandt, and Rainer Marquetant. "The Gi-protein as a Target for Receptor-Receptor Interactions." In Receptor-Receptor Interactions. Palgrave Macmillan UK, 1987. http://dx.doi.org/10.1007/978-1-349-08949-9_17.

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Jakobs, Karl H., Peter Gierschik, Rüdiger Grandt, and Rainer Marquetant. "The Gi-protein as a Target for Receptor-Receptor Interactions." In Receptor-Receptor Interactions. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5415-4_17.

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Lazaridis, Themis. "Ligand and Receptor Conformational Energies." In Protein-Ligand Interactions. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527645947.ch10.

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Anwar, Muhammad Ayaz, and Sangdun Choi. "Receptor-Interacting Protein Kinase." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101494.

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Colao, Annamaria, and Claudia Pivonello. "G-Protein-Coupled Receptor." In Encyclopedia of Pathology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-28845-1_5112-1.

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Conference papers on the topic "Protein Receptor"

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Jakobs, K. H., P. Gierschik, and R. Grandt. "THE ROLE OF GTP-BINDING PROTEINS EXHIBITING GTPase ACTIVITY IN PLATELET ACTIVATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644773.

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Activation of platelets by agonists acting via cell surface-located receptors apparently involves as an early event in transmembrane signalling an interaction of the agonist-occupied receptor with a guanine nucleotide-binding regulatory protein (G-protein). The activated G-protein, then, transduces the information to the effector molecule, being responsible for the changes in intracellular second messengers. At least two changes in intracellular signal molecules are often found to be associated with platelet activation by agonists, i.e., increases in inositol trisphosphate and diacylglycerol l
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Proskura, A. L., S. O. Vechkapova, and E. D. Sorokoumov. "MECHANISMS OF AMPA RECEPTOR ENDOCYTOSIS IN THE PROCESSES OF SYNAPTIC PLASTICITY OF THE HIPPOCAMPUS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-267.

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Endocytosis of AMPA type glutamate receptors is a key event in the regulation of synaptic plasticity in the hippocampus. The work presents a reconstruction of the connection of synaptic signaling pathways with the molecular mechanisms of AMPA receptor endocytosis. GeneNet technology (ROSPATENT No. 990006 dated 15/02/1999) was used to reconstruct protein-protein interactions based on open sources of the PubMed database.
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Safronova, N. A., T. S. Kurkin, M. B. Shevtsov, et al. "SAMPLE PREPARATION OF A RECEPTOR ASSOCIATED WITH MULTIPLE SCLEROSIS PATHOGENESIS FOR STRUCTURAL STUDIES USING CRYOELECTRON MICROSCOPY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-370.

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In this work, we study the GPCR class A receptor (rhodopsin-like) which is phylogenetically close to cysteinyl leukotriene and purine receptors. It is expressed in oligodendrocyte progenitor cells and regulates formation of the myelin sheath of neurons. To determine the structure of this receptor by cryoelectron microscopy, we created a stable and monomeric protein sample.
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Phillips, David R., Laurence A. Fitzgerald, Leslie V. Parise, and Israel F. Charo. "The Platelet Membrane Glycoprotein IIb-III a Complex: Member of a Superfamily of Adhesive Protein Receptors." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643727.

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The glycoprotein (GP) IIb-IIIa complex isthe receptor for fibrinogen,fibronectin and von Willebrand factor on the surface of activated platelets that mediates platelet aggregation.The GP IIb-IIIa complex contains two subunits; an a subunit, GP IIb, and a smaller 8 subunit, GP IIIa. To identify the subunits of GP IIb-IIIa responsible for fibrinogen binding, we examined the ability of purified subunitsto bind to immobilized fibrinogen. Both the GP IIb and the GP III a subunits have fibrinogen binding activity, suggesting that fibrinogen binds to multiple sites onthe GP I Ib-IIIa complex.A GP Ilb
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Maciaszek, J. L., B. Andemariam, and G. Lykotrafitis. "Red Blood Cell Surface Receptor Expression of BCAM/Lu is Regulated by Protein Kinase A Activity." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14311.

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Irregular sickle red blood cells (RBCs) can contribute to the pathogenesis of vasoocclusion and other complications of sickle cell disease (SCD) via abnormal adherence to the vascular endothelium. It has previously been demonstrated that epinephrine enhances SCD RBC adhesion by activating the BCAM/Lu and ICAM-4 surface receptors [1–2]. Epinephrine acts on the RBC β2-adrenergic receptor, thereby activating Gas proteins that stimulate adenylyl cyclase (AC). This enzyme catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), leading to protein kinase A (
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Fang, Ye, Anthony G. Frutos, and Joydeep Lahiri. "G protein-coupled receptor (GPCR) microarrays." In International Symposium on Biomedical Optics, edited by Darryl J. Bornhop, David A. Dunn, Raymond P. Mariella, Jr., et al. SPIE, 2002. http://dx.doi.org/10.1117/12.472073.

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Timkin, Pavel, E. Timofeev, A. Chupalov, and Evgeniy Borodin. "ANALYSIS AND SELECTION OF LIGANDS FOR TRPM8 USING HARD DOCKING AND MACHINE LEARNING." In XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9b233509.17835494.

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In this work, using the in-silico experiment modeling method, the receptor and its ligands were docked in order to obtain the data necessary to study the possibility of using machine learning and hard intermolecular docking methods to predict potential ligands for various receptors. The protein TRPM8 was chosen, which is a member of the TRP superfamily of proteins and its classic agonist menthol as a ligand. It is known that menthol is able to bind to tyrosine 745 of the B chain. To carry out all the manipulations, we used the Autodock software and a special set of graphic tools designed to wo
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Giancotti, F. G., L. R. Languino, A. Zanetti, G. Grignani, G. Tarone, and E. Dejana. "PLATELETS EXPRESS A MEMBRANE PROTEIN COMPLEX IMMUNOLOGICALLY RELATED TO THE FIBROBLAST FIBRONECTIN RECEPTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643909.

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The heterodimer complex GpIIb-IIIa on human platelets can specifically bind fibronectin (FN) only when platelets are activated by thrombin. However unstimulated platelets can adhere and spread on a FN substratum. This suggests the existence of a second binding site for FN on the platelet surface that does not require activation for its expression. We have previously identified and characterized a membrane glycoprotein complex (Gp 150/135) that functions as fibronectin receptor (FN-R) in mouse fibroblast adhesion. To investigate whether this molecule was also present in platelets we have produc
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Hawiger, J. "PLATELET RECEPTOR RECOGNITION DOMAINS AND THEIR SYNTHETIC PEPTIDE ANALOGS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643726.

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Adhesive molecules and their receptorsplay an essential role in hemostasis and thrombosis. Platelet thrombi are formed through the interaction of cell adhesion molecules (CAMs) with intercellular adhesion molecules (IAMs)and substrate adhesion molecules (SAMs). Platelet CAMs encompass membrane glycoproteins lb, lib, Ilia,and possibly la and IV, which constitutemembrane receptors for IAMs(e.g., fibrinogen) and for SAMs encompassingvon Willebrand Factor (vWF), fibronectin, vitronectin, collagen, and thrcmbospondin. Receptorfunction of platelet CAMs can be specific,i.e., only one adhesive protein
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Bowry, S. K., and M. Tepel. "NON-REVERSIBLE BINDING OF 5'-p-FLUOROSULFONYLBENZOYL ADENOSINE TO WASHED INTACT PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643506.

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ADP is an important in vivo mediator of platelet aggregation. The identification and estimation of a finite number of receptor sites has been made difficult by the reversible nature of the action of ADP on platelets and because ADP can be degraded by enzymes on the platelet surface. Analogues of ADP have therefore been commonly used to study the ADP receptor. We investigated the validity of using 5'-p-fluorosulfonylbenzoyl adenosine (FSBA), an affinity analogue of ADP that inhibits ADP-induced aggregation, for studying the ADP receptor on intact washed platelets. Binding of labelled FSBA, like
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Reports on the topic "Protein Receptor"

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Avni, Adi, and Gitta L. Coaker. Proteomic investigation of a tomato receptor like protein recognizing fungal pathogens. United States Department of Agriculture, 2015. http://dx.doi.org/10.32747/2015.7600030.bard.

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Maximizing food production with minimal negative effects on the environment remains a long-term challenge for sustainable food production. Microbial pathogens cause devastating diseases, minimizing crop losses by controlling plant diseases can contribute significantly to this goal. All plants possess an innate immune system that is activated after recognition of microbial-derived molecules. The fungal protein Eix induces defense responses in tomato and tobacco. Plants recognize Eix through a leucine-rich-repeat receptor- like-protein (LRR-RLP) termed LeEix. Despite the knowledge obtained from
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Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut
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Thongtan, Thananya, Poonlarp Cheepsunthorn, and Kiat Ruxrungtham. An analysis and studies expression of receptor molecule on microglia cells to inhibits infection of the cells from Japanese encephalitis virus : Research report (Year 2009). Chulalongkorn University, 2009. https://doi.org/10.58837/chula.res.2009.14.

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Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is a major cause of viral encephalitis in Asia. Even though the principle target cells for JEV in the central nervous system are neurons, the microglia is activated in response to JEV infection. This research aimed to investigate the relationship between JEV and microglial cells. The percentage of JEV infectivity in mouse microglial (BV-2) cell line at 8, 15 and 24 hr post infection was determined by flow cytometry. It was found that the percentage of infected cells were approximately 53.5, 71.3 and 83.6 respectively. The JEV bind
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Gumerlock, Paul H. Protein Interaction with the N-Terminus of the Androgen Receptor. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada421196.

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Gumerlock, Paul H. Protein Interaction with the N-Terminus of the Androgen Receptor. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada384350.

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Rafaeli, Ada, Russell Jurenka, and Daniel Segal. Isolation, Purification and Sequence Determination of Pheromonotropic-Receptors. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7695850.bard.

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Moths constitute a major group of pest insects in agriculture. Pheromone blends are utilised by a variety of moth species to attract conspecific mates, which is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). Our working hypothesis was that, since the emission of sex-pheromone is necessary to attract a mate, then failure to produce and emit pheromone is a potential strategy for manipulating adult moth behavior. The project aimed at identifying, characterising and determining the sequence of specific receptors responsible for the interaction w
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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are
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Srinivasan, Sathish. Involvement of Novel Multifunction Steroid Hormone Receptor Coactivator, E6-Associated Protein, in Prostate Gland Tumorigenesis. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada500946.

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Liu, Mingyao. Role of a Novel Prostate-Specific G-Protein Coupled Receptor (PSGR) in Prostate Tumor Development. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada415521.

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Srinivasan, Sathish. Involvement of Novel Multifunction Steroid Hormone Receptor Coactivator, E6-Associated Protein, in Prostate Gland Tumorigenesis. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada524513.

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