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Dissertations / Theses on the topic 'Protein Receptor'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Magno, Aaron. "Proteins associated with the intracellular signalling tail of the calcium-sensing receptor and their impact on receptor function." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0028.

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[Truncated abstract] The calcium-sensing receptor (CaR) is a G protein-coupled receptor that can respond to changes in extracellular calcium and plays an integral role in calcium homeostasis. Later studies revealed that the CaR was stimulated by not just calcium, but a diverse range of stimuli and that activation of the receptor regulated a host of different biological processes. The CaR is linked to these cellular responses via the various signalling pathways initiated by the receptor. Recent yeast two-hybrid studies have identified a number of accessory proteins that, through their interacti

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2

Nguyen, Giang Huong. "A functional analysis of the human LPA₁G protein coupled receptor." Thesis, Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131304/unrestricted/nguyen%5Fgiang%5Fh%5F200405%5Fms.pdf.

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3

Davidson, L. "Protein-protein interactions in GnRH receptor signalling." Thesis, University of Edinburgh, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649167.

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Human embryonic kidney (HEK) 293 cells, stably expressing the rat GnRH receptor were used to investigate the mechanism of ERK activation by GnRH. ERK activation was found to be dependent on cell adhesion to the extracellular matrix, and required an intact actin cytoskeleton. Through the use of specific pharmacological inhibitors and expression of dominant negative cDNA constructs, ERK activation was found to be mediated by the Rho family GTPase Rac1, and the non-receptor tyrosine kinases Src and focal adhesion kinase (FAK). FAK was found to function as a tyrosine phosphorylated scaffold upon

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4

Plouffe, Bianca. "Comprehensive Model of G Protein-coupled Receptor Regulation by Protein Kinase C: Insight from Dopamine D1 and D5 Receptor Studies." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20577.

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Dopamine receptors belong to the G protein-coupled receptor (GPCR) superfamily and are classified into two families: D1-like (D1R and D5R) and D2-like (D2R, D3R and D4R), based on their ability to stimulate or inhibit adenylyl cyclase (AC). Classically, GPCRs (including D2R and D3R) are desensitized by the activation of the serine/threonine protein kinase C (PKC) upon phorbol-12-myristate-13-acetate (PMA) treatment. Previous studies demonstrate that while human D5R (hD5R) is also strongly desensitized upon PMA treatment, the human D1R (hD1R) undergo a robust PMA-induced sensitization. The aim

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5

Tchetchelnitski, V. "Regulation of neurotrophin receptors by receptor-type protein tyrosine phosphatases." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1310477/.

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Reversible protein phosphorylation plays a key role in cell signalling during neural development and thus controls cell proliferation, survival, differentiation and function. Kinases and their counter-partners the phosphatases tightly regulate protein phosphorylation. In the developing nervous system the neurotrophin receptor family of protein tyrosine kinases (TrkA, B and C) are major players in this signalling network during normal neuron development and also in several diseases such as neuropathies, degenerative disorders and cancers. Recently, receptor-type protein tyrosine phosphatases (R

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6

Borroto, Escuela Dasiel Oscar. "Human M3 muscarinic acetylcholine receptor protein-protein interactions: roles in receptor signaling and regualation." Doctoral thesis, Universitat Politècnica de Catalunya, 2008. http://hdl.handle.net/10803/22678.

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Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate various functions in the central and peripheral nervous systems. These include modulation of exocrine glandular secretion, vasodilatation and smooth muscle contraction, cell proliferation or survival, neural development and synaptic plasticity. mAChRs are activated by both endogenously produced acetylcholine and exogenously administered muscarinic compounds. Pharmacological, anatomical and molecular studies have demonstrated the existence of five muscarinic receptor subtypes, denoted as muscarinic M1, M2, M3, M4 and M5, whi

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7

Dhananjayan, Sarath Chandran. "Receptor Selective Coactivators: Characterization of a Novel Protein-Protein Interaction Module in Steroid Hormone Receptor Signaling." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/67.

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WW-domain binding protein-2 (WBP-2) was cloned as an E6-associated protein (E6-AP) interacting protein and its role in steroid hormone receptor (SHR) function was investigated. We show that WBP-2 differs from other SHR coactivators, as it specifically enhanced the transactivation functions of progesterone receptor (PR) and estrogen receptor (ER alpha), whereas it had no significant effect on the androgen receptor, glucocorticoid receptor or the activation functions of p53 or VP-16. We also demonstrated that, like other well characterized coactivators, WBP-2 contains an intrinsic activation dom

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8

McAinsh, Kristina. "Investigations of GABAA receptor phosphorylation and receptor-protein interactions." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445690/.

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GABAA receptors mediate the majority of fast synaptic inhibition in the adult mammalian brain, and play a critical role in controlling neuronal excitability during development. The functional properties and stability of cell-surface GABAA receptors are key determinants of the efficacy of GABAergic neurotransmission. I therefore employed a broad spectrum of biochemical, and cell and molecular biological techniques to identify molecular interactions that may be involved in regulating the activity and number of GABAA receptors at the neuronal surface. In this thesis, I identified a novel interact

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9

King, Martin John. "Insulin receptor phosphotyrosyl protein phosphates." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241611.

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10

Sallander, Eva Jessica. "The mechanism of G protein coupled receptor activation: the serotonin receptors." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/77901.

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Una de las principales cuestiones en farmacología molecular de los GPCR es entender los mecanismos estructurales de las siete hélices transmembrana (TM) que se producen para estabilizar ya sea Rg o los diferentes estados R*. Para entender el mecanismo que cambia el equilibrio del conjunto a un estado activo R* se construyeron tres de los receptores de la serotonina (5-HT4, 5-HT6, y 5 HT7) sobre la base de su información más reciente de cristalografía de rayos X. Dando lugar a dos modelos de cada receptor: una inactiva y otra activa. Los modelos, mejorados y evaluados con la ayuda de datos fa

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11

Gros, Robert. "Regulation of G-protein-coupled receptor function, a role for increased G-protein-coupled receptor kinase-2 protein content." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0019/NQ58133.pdf.

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12

Vestergaard, Henrik Tang. "Diversity in competitive ligand-receptor interactions : electrophysiological studies of ligand-receptor interactions at native and recombinant GABAA receptors /." Cph. : Department of Pharmacology, The Danish University of Pharmaceutical Sciences, 2003. http://www.dfh.dk/phd/defences/henriktangvestergaard.htm.

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13

Hower, Amy Elizabeth. "Receptor Functions of the Receptor-Type Protein Tyrosine Phosphatase PTPRO." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/303.

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Protein tyrosine phosphorylation regulates many aspects of cell growth and differentiation. Since cellular tyrosine phosphorylation levels are controlled by the antagonizing actions of the protein tyrosine kinases (PTKs) and the protein tyrosine phosphatases (PTPs), these enzymes play a direct role in regulating processes as diverse as oncogenesis and neuronal development. In particular, the transmembrane group of PTPs, known as the receptor-type protein tyrosine phosphatases (RPTPs), has been linked to regulation of axon growth and guidance during development and regeneration. The regulati

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14

Legate, Kyle R. Andrews D. W. "Characterization of the beta-subunit of the mammalian SRP receptor and its role in assembly of the SRP receptor /." *McMaster only, 2003.

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15

Kidley, N. J. "Modelling G protein-coupled receptor activation." Thesis, University of Essex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402792.

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16

Terasmaa, Anton. "Dopamine D2 receptor G protein coupling and its regulation /." Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-788-6/.

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17

Lew, Gregory John. "Studies on protein phosphorylation in response to insulin in isolated cellular fractions reconstituted with insulin receptors." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27979.

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The mechanism by which insulin and other polypeptide growth factors alter cellular metabolism is not fully understood. In the case of insulin, it is thought that phosphorylation/dephosphorylation mechanisms may play a central role in the signalling pathway. This is based on evidence which includes demonstration that the receptor for insulin is a tyrosine-specific protein kinase which is activated in response to insulin binding. Ultimately, insulin binding to its receptor on the surface of intact fat cells leads to altered levels of serine phosphorylation of several soluble proteins, including

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18

Smith, Lucy. "Investigating inhibitors of the IgE:high affinity receptor protein-protein interaction." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44210.

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The protein-protein interaction (PPI) between immunoglobulin E (IgE) and its high affinity receptor (FcεRI) is an important part of the allergic response. Inhibition of the IgE:FcεRI interaction is a key strategy for the development of allergy treatments. This PPI has been validated as a therapeutic target by the humanised monoclonal antibody omalizumab, which binds to IgE and prevents the formation of the IgE:FcεRI complex and has proved successful at treating allergic asthma. However, small molecule inhibitors of the IgE:FcεRI PPI that are orally available would be a more desirable form of t

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19

Cox, Alan. "The receptor for sodium cromoglycate in plasma membranes : post receptor phosphorylation events." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254666.

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20

Kvachnina, Elena. "Characterization of the 5-HT7(a) receptor specific receptor G protein interactions /." Doctoral thesis, [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972602003.

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21

Widén, Christina. "Studies of glucocorticoid receptor interacting proteins /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-322-1/.

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22

Kvachnina, Elena. "Characterization of the 5-HT₇(a) receptor specific receptor-G-protein interactions /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972602003.

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23

Castro, Diogo Sampaio e. "Functional studies on the orphan receptor Nurr1 and related retinoid receptors /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4608-6/.

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24

Kazlauskas, Arunas. "Regulation of dioxin receptor function by the Hsp90 chaperone complex /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-176-4.

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25

Gatehouse, Michelle. "Desensitisation of the pituitary vasopressin receptor : development of a model system to assess involvement of G protein-coupled receptor kinase 5." Thesis, University of Canterbury. School of Biological Sciences, 2008. http://hdl.handle.net/10092/2627.

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The hypothalamic peptide arginine vasopressin (AVP) is an important regulator of adrenocorticotropin (ACTH) release from the anterior pituitary. AVP stimulates ACTH secretion from corticotroph cells by activating the pituitary vasopressin receptor (V1b-R), a member of the G protein-coupled receptor (GPCR) family. In vitro, repeated stimulus of anterior pituitary cells with AVP results in rapid desensitisation. The aim of this research was to develop methods needed to use RNA interference (RNAi) to investigate the role of G protein-coupled receptor kinase 5 (GRK5) in this desensitisation proces

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26

Harding, Peter J. "A biophysical study of the G protein coupled receptor neurotensin receptor 1." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:0e84f351-696f-42c9-b2fd-8afcde6d586e.

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Neurotensin (NT) is a tridecapeptide neurotransmitter found in the central nervous system and gastrointestinal tract. Neurotensin receptor 1 (NTS1), a high affinity receptor for NT, is a member of the GPCR superfamily and is a putative target for the treatment of conditions such as Schizophrenia, Parkinson’s Disease and drug addiction. Overexpression and purification are typically limiting steps in the high resolution structure determination of GPCRs. In this study, through the optimisation of the E.coli strain used for overexpression of rat NTS1 (NTS1) and the inclusion of phospholipids in th

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27

Smith, Tricia. "Effects of Cannabinoid Receptor Interacting Protein (CRIP1a) on Cannabinoid Receptor (CB1) Function." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1977.

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EFFECTS OF CANNABINOID RECEPTOR INTERACTING PROTEIN (CRIP1a) ON CANNABINOID (CB1) RECEPTOR FUNCTION. By Tricia Hardt Smith, B.S., M.S. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2009. Major Director: Dana E. Selley, Ph.D., Department of Pharmacology and Toxicology This dissertation examines modulation of cannabinoid CB1 receptor function by Cannabinoid Receptor Interacting Protein (CRIP1a), a novel protein that binds the C-terminus of CB1 receptors. In Human

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28

Dasso, Leonardo. "Receptor-G protein interactions in rat hepatocytes." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282114.

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29

White, Colin D. "Dissection of GnRH receptor-G protein coupling." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3885.

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Hypothalamic gonadotropin-releasing hormone (GnRH) (GnRH I) is the central regulator of the mammalian reproductive system. Most vertebrates studied also possess a second form of GnRH, GnRH II. GnRH I acts on its cognate G proteincoupled receptor (GPCR) on pituitary gonadotropes and activates Gq/11-mediated signalling pathways to stimulate the biosynthesis and the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH). Both GnRHs have also been suggested to inhibit cellular proliferation, an action which has largely been proposed to be mediated by the coupling of the recepto

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30

Slessareva, Janna Eugenievna. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2907.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vi, 200 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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31

Ma, Hongzheng. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2978.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains viii, 264 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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32

Zazzu, Valeria. "The human G protein-coupled receptor GPR30." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16325.

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Im 1997 wurden der Orphan GPR30 aus HUVECs kloniert, die FSS ausgesetzt waren. In dieser Studie konnte gezeigt werden dass die Expression von GPR30 durch die FSS-Behandlung im Vergleich zu unbehandelten HUVEC-Zellen deutlich induziert wurde. Daraufhin wurde in einer Studie von Isensse et al. die zelluläre und gewebsspezifische Expression von GPR30 in GPR30-LacZ Reportergen-Mäusen untersucht. Es konnte eine Expression von GPR30 vorwiegend in den Endothelzellen der kleinen Arterien verschiedenster Gewebetypen nachgewiesen werden. GPR30 war postuliert dass E2 direkt binden kann und dadurch rasche

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33

Hatcher-Solis, Candice N. "PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A RECEPTOR- DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4458.

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G protein-coupled receptors (GPCRs) are heptahelical, transmembrane proteins that mediate a plethora of physiological functions by binding ligands and releasing G proteins that interact with downstream effectors. GPCRs signal as monomers, complexes of the same receptor subtype (homomers), or complexes of different receptor subtypes (heteromers). Recently, heteromeric GPCR complexes have become attractive targets for drug development since they exhibit distinct signaling and cell-specific localization from their homomeric counterparts. Yet, the effect of heteromerization on the pharmacology of

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34

Xue, Chunyi, and 薛春宜. "Molecular characterization of infectious bursal disease virus (IBDV) receptor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246187.

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35

Bahena, Silvia. "Computational Methods for the structural and dynamical understanding of GPCR-RAMP interactions." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-416790.

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Protein-protein interaction dominates all major biology processes in living cells. Recent studies suggestthat the surface expression and activity of G protein-coupled receptors (GPCRs), which are the largestfamily of receptors in human cells, can be modulated by receptor activity–modifying proteins (RAMPs). Computational tools are essential to complement experimental approaches for the understanding ofmolecular activity of living cells and molecular dynamics simulations are well suited to providemolecular details of proteins function and structure. The classical atom-level molecular modeling o

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36

Thomas, Jennifer Ann. "Engineering the angiotensin II type 1 receptor for structural studies." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/247919.

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G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that perform transmembrane signal transduction. Due to their pivotal role in a wide range of essential physiological functions GPCRs represent a high proportion of all drug targets. High resolution X-ray structures of GPCRs are however underrepresented in the Protein Data Bank. This is due to their instability in detergent, low expression levels and the presence of misfolded receptors in many heterologous expression systems. The objective of this project was to engineer the angiotensin II type 1 receptor (AT1R), a hu

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37

Bane, Steven Edward. "Expression and characterization of the human neurokinin 1 receptor from Escherichia coli." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 99 p, 2007. http://proquest.umi.com/pqdweb?did=1342742951&sid=1&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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38

Kumas, Gozde. "Detecting G-protein Coupled Receptor Interactions Using Enhanced Green Fluorescent Protein Reassembly." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614136/index.pdf.

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The largest class of cell surface receptors in mammalian genomes is the superfamily of G protein-coupled receptors (GPCRs) which are activated by a wide range of extracellular responses such as hormones, pheromones, odorants, and neurotransmitters. Drugs which have therapeutic effects on a wide range of diseases are act on GPCRs. In contrast to traditional idea, it is recently getting accepted that G-protein coupled receptors can form homo- and hetero-dimers and this interaction could have important role on maturation, internalization, function or/and pharmacology. Bimolecular fluorescence com

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39

Villegas-MeÌndez, Ana. "Endothelial cell protein C receptor interactions with protein C and proteinase 3." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417119.

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40

Higgs, C. "A computational study of the G-protein-G-protein coupled receptor interaction." Thesis, University of Essex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324216.

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Haudenschild, Dominik Rudolf. "Bone morphogenetic protein and interleukin-17 receptor-like protein in prostate cancer /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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42

Sawzdargo, Marek. "Discovery of novel G protein-coupled receptor genes including human GALR3 receptor gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0003/MQ46146.pdf.

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43

Panetta, Rosemarie. "Human somatostatin receptor 5(hSSTR5) : a novel pituitary selective G protein-coupled receptor." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40419.

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Using a combination of polymerase chain reaction (PCR) and genomic library screening, a human (h) gene for a subtype of the somatostatin (SST) receptor (SSTR), termed hSSTR5, was cloned. Human SSTR5 consists of a 363-residue polypeptide exhibiting a putative seven-transmembrane domain topology typical of G protein-coupled receptors. The receptor displays 45% to 52% sequence identity to the other four cloned hSSTR subtype genes (SSTRl-SSTR4). Pharmacological analysis of hSSTR5 revealed that this receptor bound SST-28 with a 12.6-fold greater affinity compared with SST-14, indicating that hSSTR5

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44

Vaillancourt, François 1978. "TRAF4 is a cytosolic p75 neurotrophin receptor interacting protein that alters receptor trafficking." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79149.

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The signaling properties of the p75 neurotrophin receptor (p75NTR) have been difficult to ascertain but new insights are emerging from a detailed characterization of cytosolic p75NTR interacting proteins. TRAF (Tumor Necrosis Factor Receptor-associated Factors) proteins are a family of cytosolic adaptors that link members of the TNF superfamily to the JNK, NF-kB and Src signaling cascades. We show, using a GST pull down assay, that TRAF4 binds the p75NTR intracellular domain with high affinity in the juxtamembrane region. Of the remaining TRAFs, only TRAF6 bound p75NTR and much less avi

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Mikaliunaite, Lina. "Engineering yeast for G protein-coupled receptor functional studies : pharmacological characterisation of adrenergic receptors." Thesis, Aston University, 2018. http://publications.aston.ac.uk/33611/.

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G protein-coupled receptors (GPCRs) are membrane proteins responsible for myriad physiological functions. Around a third of drugs on the market already target GPCRs. However, the emphasis on developing GPCR assays to screen compound libraries for potential GPCR-interacting drugs is still very strong. One such cell-based assay was developed at GlaxoSmithKline (GSK) by Dowell and Brown [1, 2]. This assay uses a cheap, rapidly growing unicellular organism – baker’s yeast. In this organism the pheromone signalling pathway is one of only two GPCR-activated pathways. Yeast engineering done at GSK in

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Wiencko, Heather L. Dervan Peter B. Goddard William A. "Adrenergic receptors : model systems for investigation of G-protein coupled receptor structure and function /." Diss., Pasadena, Calif. : California Institute of Technology, 2009. http://resolver.caltech.edu/CaltechETD:etd-05292009-094239.

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Munton, Richard Paul. "Investigation of protein kinase-A dependant GABAb receptor desensitisation and characterisation of a novel family 3 G-protein coupled receptor." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398537.

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Schwimmer, Lauren J. "Engineering ligand-receptor pairs for small molecule control of transcription." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-06282005-172608/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2006.<br>Doyle, Donald, Committee Chair ; Radhakrishna, Harish, Committee Member ; Bommarius, Andreas, Committee Member ; Orville, Allen, Committee Member ; Seley, Katherine, Committee Member.

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Rankin, Saffron Emily. "Lipid-protein interactions and nicotinic acetylcholine receptor function." Thesis, University of Oxford, 1996. https://ora.ox.ac.uk/objects/uuid:3deca85b-9f09-4f72-9db3-e34851e10542.

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The effect of bilayer composition, specifically the presence of cholesterol, upon the function of the reconstituted nicotinic acetylcholine receptor (nAcChoR) was investigated using stopped-flow fluorescence. The nAcChoR was purified and reconstituted from the electroplaques of Torpedo nobiliana, using affinity column chromatography, into bilayers of defined composition and the function of each sample assessed and compared with those of the native receptor. Investigation of the effect of bilayer composition upon the kinetics of agonist binding to the nAcChoR, using the fluorescent acetylcholin

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Nichol, Donna. "Analysis of receptor interacting protein (RIP140) gene expression." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434341.

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