Academic literature on the topic 'Protein stabilizer'

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Journal articles on the topic "Protein stabilizer"

1

Elmowafy, Mohammed, Nabil K. Alruwaili, Khaled Shalaby, et al. "Long-Acting Paliperidone Parenteral Formulations Based on Polycaprolactone Nanoparticles; the Influence of Stabilizer and Chitosan on In Vitro Release, Protein Adsorption, and Cytotoxicity." Pharmaceutics 12, no. 2 (2020): 160. http://dx.doi.org/10.3390/pharmaceutics12020160.

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Long-acting preparations containing the antipsychotic paliperidone for intramuscular injection has drawn considerable attention to achieve harmless long-term treatment. This study aimed to develop paliperidone loaded polycaprolactone (PCL) nanoparticles and investigate the influence of PCL/drug ratio, stabilizer type, and chitosan coating on physicochemical properties, protein adsorption, and cellular toxicity. Results showed that chitosan coating produced enlarged particle sizes, shifted the surface charges from negative into positive and did not influence encapsulation efficiencies. Chitosan
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McLaren, R. S., N. Caruccio, and J. Ross. "Human La protein: a stabilizer of histone mRNA." Molecular and Cellular Biology 17, no. 6 (1997): 3028–36. http://dx.doi.org/10.1128/mcb.17.6.3028.

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Histone mRNA is destabilized at the end of S phase and in cell-free mRNA decay reaction mixtures supplemented with histone proteins, indicating that histones might autoregulate the histone mRNA half-life. Histone mRNA destabilization in vitro requires three components: polysomes, histones, and postpolysomal supernatant (S130). Polysomes are the source of the mRNA and mRNA-degrading enzymes. To investigate the role of the S130 in autoregulation, crude S130 was fractionated by histone-agarose affinity chromatography. Two separate activities affecting the histone mRNA half-life were detected. The
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Balasubramaniyam, Thananjeyan, Takumi Ishizuka, Chao-Da Xiao, Hong-Liang Bao, and Yan Xu. "2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA." Molecules 23, no. 10 (2018): 2572. http://dx.doi.org/10.3390/molecules23102572.

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In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study of Z-RNA remains a challenge. In this study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of m8Gm into RNA can markedly stabilize the Z-RNA at low salt conditions. Using the m8Gm-contained Z-RNA, we determined the structure of Z-RNA and investigated the interaction of protein and Z-RNA.
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David, Shlomit, Maya Magram Klaiman, Avi Shpigelman, and Uri Lesmes. "Addition of Anionic Polysaccharide Stabilizers Modulates In Vitro Digestive Proteolysis of a Chocolate Milk Drink in Adults and Children." Foods 9, no. 9 (2020): 1253. http://dx.doi.org/10.3390/foods9091253.

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There is a need to better understand the possible anti-nutritional effect of food stabilizers on the digestibility of important macronutrients, like proteins. This study hypothesized that the anionic nature of κ-, ι-, λ-, Carrageenan (CGN) and xanthan gum directs their interactions with food proteins leading to their subsequent attenuated digestive proteolysis. Model chocolate milk drinks were tested for their colloidal properties, viscosity and proteolytic breakdown in adults and children using in vitro digestion models coupled with proteomic analyses. SDS-PAGE analyses of gastro-intestinal e
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Milroy, Lech-Gustav, Maria Bartel, Morkos A. Henen, et al. "Stabilizer-Guided Inhibition of Protein-Protein Interactions." Angewandte Chemie 127, no. 52 (2015): 15946–50. http://dx.doi.org/10.1002/ange.201507976.

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Milroy, Lech-Gustav, Maria Bartel, Morkos A. Henen, et al. "Stabilizer-Guided Inhibition of Protein-Protein Interactions." Angewandte Chemie International Edition 54, no. 52 (2015): 15720–24. http://dx.doi.org/10.1002/anie.201507976.

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Serdar Akin, M., Busra Goncu, and Mutlu B. Akin. "Designing an industrial protocol to develop a new fat-reduced- ice cream formulation by replacing stabilizers with microbial transglutaminase enzyme." Mljekarstvo 69, no. 3 (2019): 162–71. http://dx.doi.org/10.15567/mljekarstvo.2019.0302.

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In this study, the possibility of replacing stabilizers with microbial transglutaminase (MTG) enzyme in fat-reduced ice cream production was studied. In addition, the stage of adding (before or after the heat treatment) the MTG enzyme to ice cream was also investigated. Five different ice creams (A and C containing 1 unit MTG/g protein without stabilizer, B and D containing 0.5 unit MTG/g protein and 0.35 % stabilizer, which also consist of the mixture of Carrageenan (E 407), Guar gum (E 412), Xanthan gum (E 415) and Sodium alginate (E 401), and E (control) containing 0.7 % stabilizer) were ma
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Kaushik, Jai K., and Rajiv Bhat. "Why Is Trehalose an Exceptional Protein Stabilizer?" Journal of Biological Chemistry 278, no. 29 (2003): 26458–65. http://dx.doi.org/10.1074/jbc.m300815200.

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Majumder, Manna. "Depolymerized Chitosan: A Novel Milk Protein Stabilizer." Advances in Bioscience and Bioengineering 3, no. 6 (2015): 56. http://dx.doi.org/10.11648/j.abb.20150306.11.

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Diana, Jebun Nessa, Ying Tao, Qiran Du, et al. "PLGA Microspheres of hGH of Preserved Native State Prepared Using a Self-Regulated Process." Pharmaceutics 12, no. 7 (2020): 683. http://dx.doi.org/10.3390/pharmaceutics12070683.

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The challenges of formulating recombinant human growth hormone (rhGH) into sustained-release polymeric microspheres include two mutual causal factors, protein denaturing by the formulation process and severe initial burst release related with relative high dose. The stabilizers to protect the proteins must not evoke osmotic pressure inside the microspheres, and the contact of the protein with the interface between water and organic solution of the polymer must be minimized. To meet these criteria, rhGH was pre-formulated into polysaccharide particles via an aqueous–aqueous emulsion in the pres
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