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Dissertations / Theses on the topic 'Protein-surface interactions'

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Published: 4 June 2021
Last updated: 26 July 2025

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1

Garutti, Claudio. "Prediction of Protein-Ligand and Protein-Protein Interactions based on Local Surface Similarity." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426155.

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The three-dimensional structure of a protein determines its function. This thesis describes a suite of methods for the problem of protein binding site recognition, based on a spin-images representation of the molecular surface. A procedure for cavity detection is coupled with a procedure for the recog- nition of similar regions in two proteins, and applied to the comparison of two protein's cavities, the all-to-all pairwise comparison of a set of cavities, and the recognition of multiple binding sites in one cavity. All the presented methods can be used to screen large collections of proteins.
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2

Roach, Paul. "Measurement of surface-protein interactions on novel surfaces." Thesis, Nottingham Trent University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431900.

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This thesis is concerned with the fundamental principles affecting protein adsorption. The effects of surface chemistry and topography on protein adsorption characteristics have been identified and quantified. Particular attention has been made to understand how the conformation of surface-bound proteins was affected by the surface onto which they adsorbed. Quartz crystal microbalance (QCM), UV-Vis spectroscopy and fluorometry were used to assess protein-surface affinity and amounts of protein adsorbed at surface saturation levels. Infrared spectroscopy was used to quantify protein conformatio
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3

Green, Rebecca J. "Protein/polymer interactions investigated by surface plasmon resonance." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336926.

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4

Wei, Shuai. "Protein-Surface Interactions with Coarse-Grain Simulation Methods." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3943.

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The interaction of proteins with surfaces is a major process involved in protein microarrays. Understanding protein-surface interactions is key to improving the performance of protein microarrays, but current understanding of the behavior of proteins on surfaces is lacking. Prevailing theories on the subject, which suggest that proteins should be stabilized when tethered to surfaces, do not explain the experimentally observed fact that proteins are often denatured on surfaces. This document outlines several studies done to develop a model which is capable of predicting the stabilization and de
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5

Evans, Edward James. "Protein structures and interactions at the leukocyte cell surface." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270011.

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6

Wang, Hua. "Control of protein-surface, protein-protein, and cell-matrix interactions for biomaterials as tissue engineering scaffolds /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9894.

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7

Jungar, Christina. "Affinity biosensors for carbohydrate-protein interactions using surface plasmon resonance /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/tek701s.pdf.

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8

Katira, Parag. "Characterizing and modeling protein-surface interactions in lab-on-chip devices." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0024702.

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9

Fischer, Tiffany Brink. "A structural and energetic description of protein-protein interactions in atomic detail." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4775.

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Here, we present the program QContacts, which implements Voronoi polyhedra to determine atomic and residue contacts across the interface of a protein-protein interaction. While QContacts also describes hydrogen bonds, ionic pair and salt bridge interactions, we focus on QContacts’ identification of atomic contacts in a protein interface compared against the current methods. Initially, we investigated in detail the differences between QContacts, radial cutoff and Change in Solvent Accessible Surface Area (delta-SASA) methods in identifying pair-wise contacts across the binding interface. T
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10

Nicholson, Martin William Michael. "Molecular analysis of the leukocyte cell-surface adhesion protein L-selectin." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260752.

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11

Li, Jing. "Processing, stability and interactions of lung surfactant protein C /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-582-8/.

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12

Van, Dolleweerd Craig John. "Molecular interactions between a monoclonal antibody and a streptoccocal cell-surface protein." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270154.

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13

Tidwell, Caren Diana. "Endothelial cell interactions with model surfaces : effect of surface chemistry, surface mobility, and the adsorbed protein layer /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8004.

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14

Hugoni, Ludivine. "Development of fibronectin coatings on polymeric materials : a study of protein-surface interactions." Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27319.

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L’adsorption de protéines adhésives telles que la fibronectine (Fn) à la surface d’un dispositif médical suivant son introduction dans le corps joue un rôle critique dans la réponse biologique. Afin de moduler cette réponse, la création de revêtements bioactifs à la surface des matériaux représente une stratégie à adopter. Dans ce contexte, ce projet de recherche vise à développer des revêtements capables de promouvoir des interactions cellulaires spécifiques. Ainsi, des revêtements de fibronectine ont été développés à la surface de polymères présentant un potentiel pour être utilisés comme bi
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15

Trent, Alexis Raven. "Fabrication, Characterization and Cellular Interactions of Keratin Nanomaterial Coatings for Implantable Percutaneous Prosthetics." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/94417.

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Implantable medical devices face numerous complications when interfacing with soft tissue, and are plagued by negative responses from host tissue. One such class devices are percutaneous osseointegrated prosthetics (POP). POP consist of a bone anchored titanium post that extrudes through the skin and attaches to an external prosthetic. Compared to the traditional socket interface, POPs offer better stability, limb functionality, and osseoperception for both upper and lower prosthetic limbs. Although the POP surgery technique is well established, the main disadvantage to this technology remains
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16

Wan, Fan. "Biomimetic Surface Coatings from Modular Amphiphilic Proteins." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31639.

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Engineering of biofunctional scaffolds to precisely regulate cell behavior and tissue growth is of significance in regenerative medicine. Protein-based biomaterials are attractive candidates for functionalization of scaffold surfaces since the ability to precisely control protein sequence and structure allows for fine-tuning of cell-substrate interactions that regulate cell behavior. In this thesis, a series of de novo proteins for bio-functionalization of interfaces was designed, synthesized, and studied. These proteins are based on a diblock motif consisting of a surface-active, amphiphil
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17

Tsourapas, George. "Surface engineering of poly(_D_L-lactic acid) to create polymeric supports that inhibit serum protein interactions and promote peptide interactions." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428948.

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18

Shumaker-Parry, Jennifer Sue. "Quantitative aspects of SPR spectroscopy and SPR microscopy, applications in protein binding to immobilized vesicles and dsDNA arrays /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/11600.

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19

Goldflam, Michael. "Combined use of NMR and computational tools for fragment based drug discovery targeting protein-protein interactions VEGF protein surface recognition as a case study." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/123711.

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The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or biochemical tools.The use of biologics to target protein-protein interfaces is relatively advanced; suffer although from some intrinsic drawbacks as the danger of immunogenicity, the inability to cross biological barriers efficiently and high production costs. Small molecule inhibitors do not necessarily share these drawbacks. Unfortunately the druggability of protein-protein int
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20

Rathnayake, Sewwandi S. "A BIOPHYSICAL CHARACTERIZATION OF PROTEIN-LIPID INTERACTIONS OF THE LIPID DROPLET BINDING PROTEIN, PERILIPIN 3." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1469552680.

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21

Oki, Aminat. "Characterization of the Effects of Iron on Neisseria Gonorrhoeae Surface Protein Modulation and Host Cell Interactions." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3534.

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Iron is an essential nutrient that is sequestered by iron-binding proteins in the human host resulting in a hostile environment for microbes. Neisseria gonorrhoeae, however, can utilize numerous iron-binding proteins such as transferrin and lactoferrin to acquire this nutrient. During initial infection, gonococci have access to transferrin and lactoferrin present in semen and vaginal fluids, as well as to hemoglobin present in blood during menses or disseminated infections. Consequently, the gonococcus likely encounters conditions of high iron at some stages in the course of natural infection.
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22

Sit, Kei Chun. "Investigation of the binding interactions between insulin and its receptor." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/87276/1/Kei_Sit_Thesis.pdf.

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This project investigated the interactions between insulin and its receptor. A combination of computational and experimental investigations resulted in the identification of four residues in non-canonical sites that, when mutated, had detrimental effects on insulin binding. An increased understanding of the binding mechanism will aid future research into diseases involving the insulin receptor and its relatives and could potentially lead to new therapeutic avenues to combat these health related issues.
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23

Seeger, Christian. "Revealing Secrets of Synaptic Protein Interactions : A Biosensor based Strategy." Doctoral thesis, Uppsala universitet, Biokemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220879.

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Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. Fragment library screening against the reverse transcriptase of HIV was included, as it served as an outlook for future drug discovery against ligand-gated ion channels. The protein-protein interaction studies of postsyna
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24

Jones, Christopher Michael. "Characterization of Macromolecular Protein Assemblies by Collision-Induced and Surface-Induced Dissociation: Expanding the Role of Mass Spectrometry in Structural Biology." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193581.

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This dissertation presents an investigation into the structure of macromolecular protein assemblies by mass spectrometry. The experiments described within are designed to systematically assess the analytical utility of surface-induced dissociation (SID) tandem mass spectrometry in the characterization of multi-subunit protein complexes. This is accomplished by studying the effects of ion-surface collision on the fragmentation products of protein assemblies that vary by mass, number of subunits, and protein structural features. The dissociation energetics and mechanisms of protein complexes are
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25

Pless, Elin. "Investigation of interactions with extracellular matrix proteins mediated by the CCP modules of the metabotropic GABAB receptor." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/5714.

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GABAB receptors are G-protein coupled receptors for the major inhibitory neurotransmitter in the mammalian central nervous system, γ-aminobutyric acid (GABA). The receptor is linked to a variety of disorders including epilepsy, pain, spasticity, drug addiction and cognitive impairment and is, therefore of major importance for drug discovery. The most abundant receptor isoforms GABABR1a and R1b differ by the presence in R1a of a pair of Nterminal extracellular complement control protein modules (CCP1 and CCP2) which - in other proteins - are generally involved in mediating specific protein-prot
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26

Damodaran, Vinod Babu. "Solid-phase protein PEGylation: Achieving mono-PEGylation through molecular tethering." Thesis, University of Canterbury. Chemical and Process Engineering, 2009. http://hdl.handle.net/10092/3757.

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Protein PEGylation (covalent attachment of poly(ethylene glycol) or PEG to proteins) is an excellent example of a drug delivery system that improves pharmacokinetics and pharmacodynamic properties of therapeutics. However, although PEGylation is clinically proven and attracts both scientific and commercial interest, the technique is associated with many process constraints, in particular related to controlling the number of conjugated PEG chains. A novel, solid-phase PEGylation methodology was attempted to overcome the drawbacks of the commonly used solution-phase methods for preparing PEGylat
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27

Sharma, Kamal Kant. "Molecular mechanism of the hepatitis C virus core protein chaperone properties : Physicochemical investigation by fluorescence and surface plasmon resonance." Strasbourg, 2011. https://publication-theses.unistra.fr/public/theses_doctorat/2011/SHARMA_Kamal_Kant_2011.pdf.

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La protéine core de virus de l’hépatite C (HCV) est l’une des dix protéines codées par l’ARN génomique de 9. 6kb du virus. C’est une protéine chaperonne multifonctionnelle impliquée dans plusieurs processus viraux comme la prolifération cellulaire, la différentiation, l’encapsidation de l’ARN, la formation de la nucléocapside, et la variabilité génétique. Grâce à ses propriétés de chaperonne, le domaine D1 dimérise la région 3’ non traduite (3’UTR) de l’ARN génomique. Cependant le mécanisme de cette activité chaperonne ainsi que l’interaction entre la protéine Core et différents oligonucléotid
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28

Rodriguez, Rius Maria Angeles. "Novel interfacial adsorption properties of collagenous polypeptides and their interactions with model surfactants." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/novel-interfacial-adsorption-properties-of-collagenous-polypeptides-and-their-interactions-with-model-surfactants(dd2be69e-4138-4306-9d51-3def8b9081d1).html.

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The interfacial adsorption and bulk properties of a collagenous polypeptide derived from chicken eggshell membranes, the 40 KDa polypeptide, and its mixtures with common low molecular weight (LMW) surfactants, SDS, DTAB and C10E8, have been studied for the first time using surface tension, ζ-potential, foam observations and neutron scattering techniques. The biopolymer has been shown to act as an effective biosurfactant by lowering the surface tension of water below the values commonly achieved with conventional LMW surfactants, i.e. γ = 32 ± 1 mN/m. This capability is maximized at its isoelec
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29

Cai, Yixiao. "Bio-Nano Interactions : Synthesis, Functionalization and Characterization of Biomaterial Interfaces." Doctoral thesis, Uppsala universitet, Tillämpad materialvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-277121.

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Current strategies for designing biomaterials involve creating materials and interfaces that interact with biomolecules, cells and tissues.  This thesis aims to investigate several bioactive surfaces, such as nanocrystalline diamond (NCD), hydroxyapatite (HA) and single crystalline titanium dioxide, in terms of material synthesis, surface functionalization and characterization. Although cochlear implants (CIs) have been proven to be clinically successful, the efficiency of these implants still needs to be improved. A CI typically only has 12-20 electrodes while the ear has approximately 3400 i
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30

Capomaccio, Robin. "Interactions nanoparticules-protéines : caractérisation de la couronne protéique." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10323.

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De nos jours, les nanomatériaux sont utilisés dans de très nombreux domaines allant de l’agroalimentaire à la santé en passant par l’industrie automobile et le textile. Dans ce contexte, de nombreuses disciplines comme la métrologie et la nanotoxicologie se sont fortement développées. Dans les milieux biologiques, les protéines interagissent avec les nanoparticules pour former une couronne de protéines. Cette couronne de protéines joue un rôle important dans les interactions des nanoparticules avec leur environnement. Comprendre et caractériser les interactions des nanoparticules avec les prot
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31

Christmann, Sarah [Verfasser]. "Synthesis of functional amphiphilic block copolymers as stabilizer for various nanocarriers and further surface functionalization to change protein interactions / Sarah Christmann." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1131115260/34.

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32

Safazadeh, Haghighi Leila. "DESIGN OF HIGHLY STABLE LOW-DENSITY SELF-ASSEMBLED MONOLAYERS USING THIOL-YNE CLICK REACTION FOR THE STUDY OF PROTEIN-SURFACE INTERACTIONS." UKnowledge, 2016. http://uknowledge.uky.edu/cme_etds/61.

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Protein adsorption on solid surfaces is a common yet complicated phenomenon that is not fully understood. Self-assembled monolayers have been utilized in many studies, as well-defined model systems for studying protein-surface interactions in the atomic level. Various strategies, including the use of single component SAMs[1, 2], combinations of long and short alkanethiolates with methyl- and hydroxyl- terminal groups[3, 4], and using mixtures of alkanethiolates with similar chain length and varying terminal functional group [5] have been used to effectively control the surface wettability and
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33

Talley, Edwards Allison. "Structure and Dynamics of Supramolecular Aggregate Studied Using Molecular Dynamics Simulations: Protein Adsorption at Solid Surfaces and NMR Cross Relaxation in Nonionic Micelles." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553613189008144.

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34

Border, Ellen Clare. "Structural and functional studies of cell surface receptors." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:907793da-3ba1-4a57-8bdb-c185aa84c28c.

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Receptor proteins on the surfaces of cells equip them to communicate with each other and to sense and interact with their environment. One receptor family, the αβ T-cell receptors (TCRs), allow T lymphocytes to detect and respond to pathogens via interactions with antigen-presenting major histocompatibility complex (MHC) molecules on target cells. A degree of TCR cross-reactivity (e.g. through structural similarity between peptide-MHC (pMHC) complexes) is essential to account for all possible pathogens, but can also lead to the misinterpretation of self antigens as foreign, and thereby elicit
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35

Thakar, Dhruv. "Surfaces biomimétiques pour caractériser les interactions induites par les glycosaminoglycanes aux niveaux moléculaire, supramoléculaire et cellulaire." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV005/document.

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L'adhésion contrôlée et la migration orientée des cellules est fondamentale pour plusieurs processus physiologiques et pathologiques. Une famille de polysaccharides linéaires, connus sous le nom de glycosaminoglycanes (GAG) est impliquée dans l'organisation et la présentation des protéines de signalisation, les chimiokines, à la surface des cellules et dans la matrice extracellulaire (ECM). Les travaux concernent le développement de surfaces biomimétiques bien définies aux niveaux moléculaires et supramoléculaires pour l‘étude des mécanismes d'intéractions protéines-GAG et l'analyse de la répo
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Rouhana, Jad. "Etude et modulation des interactions protéine-protéine : l’activation de la petite protéine G Arf1 par son facteur d’échange Arno." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON13507/document.

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Arf1 est une petite protéine G (pG), essentiellement impliquée dans le trafic vésiculaire. Arf1 oscille entre deux conformations, l'une active liée au GTP et l'autre inactive associée au GDP. Arno est un des facteurs d'échange (GEF) capable d'activer Arf1 en stimulant l'échange GDP/GTP. Suractivée dans les cellules invasives du cancer du sein, Arf1 joue un rôle important dans la migration et la prolifération des cellules cancéreuses.Le but de ma thèse s'inscrit dans l'étude et la modulation de l'interaction pG-GEF, et plus spécifiquement, le couple Arf1-Arno. Mon travail a été planifié autour
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Rimbault, Charlotte. "Modulation des interactions impliquant les domaines PDZ par une approche d’évolution dirigée." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0438/document.

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Les interactions protéine-protéine (IPPs), complexes et dynamiques, sont le cœur des réseaux protéiques cellulaires. Au niveau des synapses excitatrices, la densité post-synaptique (PSD) est un exemple typique de réseau protéique dont la structure et la composition à l’échelle nanoscopique détermine la fonction cellulaire. Ainsi, la régulation dynamique de la composition de la PSD et des mouvements des récepteurs au glutamate dans ou hors de la PSD constitue la base des théories moléculaires actuelles sur l’apprentissage et la mémoire. Dans ce contexte, durant ma thèse, j’ai étudié une classe
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38

Dogra, Navneet. "INVESTIGATING PROTEIN - BILAYER COMPLEXES: A STUDY OF LIGAND - RECEPTOR INTERACTIONS AT MODEL MEMBRANE SURFACE BY USING ELECTRONIC ABSORPTION SPECTROSCOPY AND FLUORESCENCE RESONANCE ENERGY TRANSFER." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/812.

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The main aim of work presented here is to design, develop and characterize a colorimetric model membrane (liposome) systems, which can bind with proteins, enzymes, bacteria, virus and other biomolecules. PDA molecules are utilized as a scaffold for the bilayer membrane, and a colorimetric assay is carried out. The holy grail of present work contributes towards the better understanding of protein interactions with the cell bilayer surface. Chapter 1 introduces a brief history on the advent of bilayer systems for cellular research exploration. We presented a literature survey about how liposom
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39

Righetto, Irene. "Towards "Systems Biotechnology": identification, characterization and design/engineering of protein interaction motifs/domains mediating regulatory signals." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426306.

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In silico investigation on protein domains structure and linear/structural motifs can strongly boost functional analyses and technological design. Protein surface features study is crucial to understanding Protein-Protein Interactions (PPI); in particular, surface and pockets conservation and variation, in terms of hydrophobicity, steric hindrance and electrostatics can act as driving forces in protein evolution and functional specialization. Therefore, molecular modeling and structure comparison techniques play an important role in shedding light on “protein behavior” and this PhD work too
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40

Teerapanich, Pattamon. "Fluorescence-based nanofluidic biosensor platform for real-time measurement of protein binding kinetics." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30239/document.

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L'analyse cinétique d'interactions de protéines offre une multitude d'informations sur les fonctions physiologiques de ces molécules au sein de l'activité cellulaire, et peut donc contribuer à l'amélioration des diagnostics médicaux ainsi qu'à la découverte de nouveaux traitements thérapeutiques. La résonance plasmonique de surface (SPR) est la technique de biodétection optique de référence pour les études cinétiques d'interaction de molécules biologiques. Si la SPR offre une détection en temps réel et sans marquage, elle nécessite en revanche des équipements coûteux et sophistiqués ainsi que
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41

González, García Cristina. "BIOLOGICAL ACTIVITY OF FIBRONECTIN AT THE CELL-MATERIAL INTERFACE." Doctoral thesis, Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/17701.

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Esta tesis aborda la actividad biológica de la fibronectina (FN) como proteína de interfase en la interacción célula-material. La tesis investiga la respuesta de la proteína, en términos de cantidad adsorbida y conformación, ante diferentes propiedades físico-químicas del material. Además, se correlaciona la respuesta celular temprana y la funcionalidad celular con el estado de la proteína adsorbida sobre el material. Para ello se prepararon diferentes series de materiales con propiedades físico-químicas controladas. La distribución de FN sobre las diferentes superficies se caracterizó median
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42

Cruz, Jimenez Juan Carlos. "Hydrolases on fumed silica : conformational stability studies to enable biocatalysis in organic solvents." Diss., Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3648.

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43

Shi, Xiaoli. "Etude de la spécificité des interactions protéine-protéine : application au complexe Alix-domaine SH3 des Src Kinases." Thesis, Aix-Marseille 1, 2011. http://www.theses.fr/2011AIX10024/document.

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Les domaines SH3 (Src Homology domain) représentent l'un des modules protéiques le plus largement répandu dans la nature. Ils participent à des interactions intra- et intermoléculaires avec d’autre partenaires au travers de la formation et de la dissociation de complexes multi-protéiques. Le gène nef du Virus d'Immunodéficience Humain (VIH-1) code pour la protéine nef, importante pour la réplication du virus et le développement optimal du SIDA (Syndrome d’Immunodéficience Acquise) chez les personnes infectées. De précédentes études ont mis en évidence que la protéine nef utilise un mode « tert
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44

Gerlach, Lisa [Verfasser]. "BamB facilitates folding of outer membrane protein A (OmpA) via interactions of its β-propeller with the membrane surface and via a conformation change induced by phosphatidylglycerol / Lisa Gerlach". Kassel : Universitätsbibliothek Kassel, 2020. http://d-nb.info/1204016488/34.

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45

Nilsson, Jonas. "Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors." Doctoral thesis, Linköpings universitet, Organisk Kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-3943.

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This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. The affinities for HCAII of the flexible, synthetic helix-loop-helix motif conjugated with a series of spacered inhibitors were measured by fluorescence spectroscopy and found in the best cases to be in the low nM range. Dissociation constants show considerable dependence on linker length and vary from 3000 nM for the shortest spacer to 40 nM for the longest with a mi
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Sereda, Alexandra. "Imagerie multi-spectrale par résonance des plasmons de surface : développement et applications." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112321/document.

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Dépistage du VIH, test de grossesse, mais également surveillance des eaux, détection de contaminants agro-alimentaires : la biodétection est au coeur des problématiques de santé actuelles. Dans ce contexte, les biocapteurs plasmoniques connaissent depuis quelques années un essor particulièrement important : de plus en plus de sociétés, telles que HORIBA Scientific, proposent des prototypes commerciaux, destinés tant à des utilisateurs du domaine de la recherche que de l'industrie. Basée sur le phénomène de résonance des plasmons de surface (communément appelé SPR) la biodétection plasmonique r
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47

Buratto, Jeremie. "Reconnaissance de surfaces protéiques par des foldamères d'oligoamides aromatiques." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0003/document.

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Les interactions protéine - protéine sont au centre de nombreux processus biologiques, et représentent des cibles thérapeutiques pertinentes pour le traitement de certaines maladies. La conception de molécules antagonistes visant à inhiber ces interactions requiert la reconnaissance spécifique d’une des surfaces protéiques impliquées. Les foldamères de type oligoamides de quinoline constituent de bons candidats. Leur production et leur fonctionnalisation sont relativement aisées. Ils adoptent des structures hélicoïdales semblables à celles rencontrées dans les protéines. Grâce à différentes te
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48

Roussille, Ludovic. "Suivi quantitatif in situ d'interactions biomoléculaire par microscopie optique SEEC." Thesis, Le Mans, 2012. http://www.theses.fr/2012LEMA1030/document.

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La microscopie SEEC (Surface Enhanced Ellipsometric Contrast) est une technique inventée au mans, il y a une dizaine d’années. Elle permet de visualiser des objets de taille nanoscopique entre polariseur et analyseur croisés en utilisant les propriétés non dépolarisantes de surfaces multicouches. Jusqu’au début de la thèse, seules des observations à l’air étaient possibles. Le but de cette thèse a consisté à adapter cette technique à l’observation in-situ d’objets en immersion dans l’eau.Pour cela, il a fallu inventer de nouvelles surfaces propres à ce nouveau milieu. Les calculs ont montrés q
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Deng, Lingquan. "Photochemical Surface Functionalization : Synthesis, Nanochemistry and Glycobiological Studies." Doctoral thesis, KTH, Organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-41973.

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This thesis mainly deals with the development of photochemical approaches to immobilize carbohydrates on surfaces for glycobiological studies. These approaches have been incorporated into a number of state-of-the-art nanobio-platforms, including carbohydrate microarrays, surface plasmon resonance (SPR), quartz crystal microbalance (QCM), atomic force microscopy (AFM), and glyconanomaterials. All the surfaces have displayed good binding capabilities and selectivities after functionalization with carbohydrates, and a range of important data have been obtained concerning surface characteristics a
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Llopis, Hernández Virginia. "Material-driven fibronectin fibrillogenesis to engineer cell function." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/90412.

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This thesis ventures with the extracellular matrix protein (ECM) fibronectin (FN) as an interface protein in the interaction between cells and materials to design microenvironment for future use in tissue engineering. It is studied the FN adsorption and conformations, cell behaviour to different FN conformation, cell adhesion, reorganisation and remodelling of FN at the material interface, the role of growth factors (GF) and their interactions with components of the extracellular matrix (ECM), the immunology cell response, and the stem cell fate influenced by the extrinsic signals coming from
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