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Dissertations / Theses on the topic 'Protein surfaces'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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1

Roach, Paul. "Measurement of surface-protein interactions on novel surfaces." Thesis, Nottingham Trent University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431900.

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This thesis is concerned with the fundamental principles affecting protein adsorption. The effects of surface chemistry and topography on protein adsorption characteristics have been identified and quantified. Particular attention has been made to understand how the conformation of surface-bound proteins was affected by the surface onto which they adsorbed. Quartz crystal microbalance (QCM), UV-Vis spectroscopy and fluorometry were used to assess protein-surface affinity and amounts of protein adsorbed at surface saturation levels. Infrared spectroscopy was used to quantify protein conformatio
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2

Mathes, Johannes. "Protein Adsorption to Vial Surfaces." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-121255.

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3

Shi, Huaiqiu Galen. "Protein recognition of template imprinted polymer surfaces /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8075.

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4

Rosengren, Åsa. "Cell-protein-material interactions on bioceramics and model surfaces /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4688.

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5

Gerstein, Mark. "Protein recognition : surfaces and conformational change." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282099.

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6

Archambault, Jacques Gérard. "Protein adsorption to polyethylene oxide-grafted surfaces /." *McMaster only, 2002.

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7

McKavanagh, Fiona. "Measrement of protein interactions on tailored surfaces." Thesis, University of Ulster, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526958.

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8

Davidson, Katrina Ann. "Protein refolding via immobilisation on crystal surfaces." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/345/.

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Is it possible to find an easy, generic method for protein refolding? The preparation of functionally active protein molecules from the unfolded state can be a difficult task. Although there are many well-established techniques for protein refolding, such as dilution, dialysis, chromatography and others, in many instances these methods can be time consuming and inefficient. A rapid, inexpensive and simple method for protein folding is a much sought after technique. Proteins in the unfolded state (either inclusion bodies or unfolded by chemical or physical means) are generally solubilised in so
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9

Bergman, Kathryn N. "Biomineralization of inorganic nanostructures using protein surfaces." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22674.

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Thesis (M. S.)--Materials Science and Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Tsukruk, Vladimir; Committee Member: Kalaitzidou, Kyriaki; Committee Member: Valeria Milam.
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10

Frazier, Richard Andrew. "Macromolecular interactions at polysaccharide surfaces." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336946.

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11

Essö, Carola. "Modifying Polydimethylsiloxane (PDMS) surfaces." Thesis, Mälardalen University, Department of Biology and Chemical Engineering, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-491.

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<p>The aim of the project was to modify polydimethylsiloxane (PDMS) surfaces in order to minimize adsorption of proteins. PDMS is used in micro-fluidic devices that control the delivery of samples to a sensor chip in Biacore instrumentation. These instruments are used to characterize interactions between biomolecules with a detection principle based on surface plasmon resonance (SPR). To minimize adsorption of proteins poly-ethylene-oxide (PEO) based surfactants, were added to the buffer. The added PEO surfactants were P20, Pluronic F-127 and Brij 35. Interaction of these surfactants with the
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12

Rosengren, Åsa. "Cell-protein-material Interactions on Bioceramics and Model Surfaces." Doctoral thesis, Uppsala University, Surface Biotechnology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4688.

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<p>The objective of this thesis was to investigate and characterize the interaction between blood proteins and different surfaces with emphasis on protein adsorption to bioceramics and model surfaces. Special effort was made to monitor the spontaneous and selective adsorption of proteins from human plasma and to examine the orientation, conformation and functional behavior of single proteins after adsorption. </p><p>Five different ceramic biomaterials: alumina (Al<sub>2</sub>O<sub>3</sub>), zirconia (ZrO<sub>2</sub>), hydroxyapatite (Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub>)
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13

Hussain, Maruf Ali. "Non-specific protein interactions at model chromatographic surfaces." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243403.

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14

Reeh, Philipp. "Dynamic Multivalency For The Recognition Of Protein Surfaces." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/283236.

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En esta tesis doctoral el concepto de multivalencia en el reconocimiento de proteínas (lectinas) con azúcares se combinó con la idea de la química dinámica combinatoria. Esto se aplicó, no sólo para sacar ventaja del efecto de la mejor afinidad de tales sistemas multivalentes, sino también para dotar al sistema con una mayor variedad de constituciones y geometrías. La determinación de las afinidades relativas de los miembros de la biblioteca dinámica dio una visión de los requisitos necesarios para la unión entre azúcares – lectina. El primer enfoque para acceder a los sistemas multivalent
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15

Lyon, Charles E. "Photo-CIDNP and protein folding." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:b16bb540-9bb1-4345-ac3a-e06910e120dc.

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The work described in this thesis is concerned with the development of new applications of the photo-CIDNP (photochemically induced dynamic nuclear polarization) technique to aspects of protein structure and folding. Chapters 1 and 2 are introductory chapters; Chapter 1 describes the theoretical basis of the CIDNP phenomenon in terms of the underlying spin chemistry of the radical pair mechanism, while Chapter 2 presents the apparatus, photosensitizer and pulse sequences used, along with some important experimental considerations. Chapter 3 describes how <sup>15</sup>N CIDNP can be used to pro
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16

Cardote, Teresa Amorim de Faria. "Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/5ac376a8-a419-4074-924d-8a4d98e4da5d.

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Cullin RING E3 ubiquitin ligases (CRLs) function in the ubiquitin proteasome system by catalysing the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins. CRLs are large dynamic multi-subunit complexes that control the fate of many proteins in cells and, therefore, constitute attractive drug targets for the development of small-molecule tools and potential drug leads, such as inhibitors and chemical inducers of protein degradation. This work presents the first crystal structure of the pentameric human CRL2VHL complex, composed of Cul2, Rbx1, Elongin B (EloB), Elong
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17

Tidwell, Caren Diana. "Endothelial cell interactions with model surfaces : effect of surface chemistry, surface mobility, and the adsorbed protein layer /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8004.

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18

Ekeroth, Sebastian. "Study of protein adsorption on structured surfaces using ellipsometry." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72165.

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In order to measure the thickness of a protein layer on a structured surface of silicon rubber, we have used ellipsometry and Fourier transform infrared (FTIR)-spectroscopy. The aim was to determine whether this type of measurement method can be used on protein layers or not. By hot-embossing a specific pattern of micrometre-sized pillars was created on the surface of the silicon rubber, which then was exposed to a phosphate buffer solution (PBS) containing human serum albumin (HSA) protein. FTIR measurements confirmed that proteins had attached to the surface. Ellipsometric studies were made
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19

Watkins, Adam. "Protein interactions with model chromatography surfaces using FTIR ATR." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272744.

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20

Liu, Li. "Complement and neutrophil activation on protein coated solid surfaces." Göteborg : Dept. of General and Marine Microbiology and Dept of medical Microbiology and Immunology, University of Göteborg, 1997. http://catalog.hathitrust.org/api/volumes/oclc/38986844.html.

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21

Bolser, Daniel Murray. "The surfaces involved in the formation of protein complexes." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612938.

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22

Wernérus, Henrik. "Engineering of staphylococcal surfaces for biotechnological applications." Doctoral thesis, KTH, Biotechnology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3450.

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<p>The engineering of bacterial surfaces has in recent yearsattracted a lot of attention with applications in manydifferent areas of bioscience. Here we describe the use of twodifferent surface display systems for the gram-positivebacteria Staphylococcus carnosus and Staphylococcus xylosus invarious biotechnological applications.</p><p>Environmental microbiology currently attracts a lot ofattention since genetically engineered plants and bacteriamight be used as bioadsorbents for sequestration of toxicmetals. Bacterial surface display of metal-binding peptidesmight enable recycling of the biom
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23

Garcia, Pindado Júlia. "Synthesis of biaryl bicyclic peptides for recognition of protein surfaces." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/403399.

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The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy was compatible with the introduction of amino acids with functional groups in their side-chains (lysine, arginine and serine). The bicyclic pentapeptides were considered privileged structures regarding the evaluated properties. The introduction of the biaryl stapled enhanced passive diffusion permeability across the blood-brain barrier (BBB). Furthermore, protease res
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24

Zicari, Agnese. "Novel application of MEMS-type surfaces to control protein crystallization." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25288.

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Addressing the problem of protein crystallization bottlenecks is a broadly regarded, but complex, research topic. High-throughput screening techniques have been developed in the recent decades to proceed with the investigations in this field. Some of these techniques are regularly used to detect the best crystallizing formulations and form crystals that are suitable for characterization. However, although slow crystallization processes can produce regular (or large) crystals, a faster growth rate is aimed for. Videlicet, gaining a certain control over the nucleation (or crystal growth) rate of
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25

Eriksson, Kristofer. "Development and Applications of Surface-Confined Transition Metal Complexes : Heterogeneous Catalysis and Anisotropic Particle Surfaces." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-88215.

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The main focus of this thesis has been directed towards developing novel surface-confined transition metal complexes for applications in heterogeneous catalysis and for the preparation of anisotropic particle surfaces. The first part describes the heterogenization of a homogeneous transition metal-based catalyst tetraphenyl cobalt porphyrin (CoTPP) on silicon wafers and on silica particles. The activity in hydroquinone oxidation for the silica particle-immobilized CoTPPs was found to be increased 100-fold compared to its homogeneous congener whereas the silicon wafer-immobilized CoTPPs achieve
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26

Danziger, David Joshua. "The computation of hydrogen-bonding and hydrophobic regions around protein surfaces." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252621.

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27

Prodan, Bjorg Noah Radu. "Modifying Membrane Surfaces via Self-Assembled Monolayers to Reduce Protein Fouling." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1091133289.

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28

Vrlinič, Tjaša. "Development of new anti-bioadhesive surfaces for specific neurodegenerative agents." Phd thesis, Université du Maine, 2011. http://tel.archives-ouvertes.fr/tel-00603911.

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Ces travaux de recherche s'inscrivent dans le cadre du développement de nouvelles surfaces biocompatibles capables de contrôler l'adhésion d'agents pathogènes responsables de maladies neurodégénératives telles que les maladies de Creutzfeld Jacob, Alzheimer, Parkinson et Lewis. Deux axes de recherche ont été privilégiés. Notre approche se focalise en amont des dosages sur l'amélioration des procédures de stockage des prélèvements biologiques réalisés dans des tubes de type Eppendorf. Ces tubes en polypropylène induisent une perte du matériel génétique de plus de 70% accentuant la faible concen
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29

Winder, Steve. "Photo-CIDNP studies of proteins." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244628.

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30

Mathes, Johannes Maximilian [Verfasser]. "Protein adsorption to vial surfaces : quantification, structural and mechanistic studies / Johannes Maximilian Mathes." Göttingen : Cuvillier, 2010. http://d-nb.info/1007905646/34.

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31

Petrou, Georgia. "Investigating mucin interactions with diverse surfaces for biomedical applications." Licentiate thesis, KTH, Glykovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-249469.

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Mucous membranes are covered with mucus, a viscoelastic hydrogel that plays an essential role in their protection from shear and pathogens. The viscoelasticity of mucus is owing to mucins, a group of densely glycosylated proteins. Mucins can interact with a wide range of surfaces; thus, there is big interest in exploring and manipulating such interactions for biomedical applications. This thesis presents investigations of mucin interactions with hydrophobic surfaces in order to identify the key features of mucin lubricity, as well as describes the development of materials that are optimized to
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32

Lebec, Victor. "Interaction of proteins with chemically controlled surfaces for biosensor development." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-01066132.

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In this work we studied protein adsorption on chemically well-controlled surfaces. The focus is put on linking physico-chemical properties of surfaces (hydrophobicity/charge) to the structural properties of the adsorbed proteins. To this end, alkyl thiols differing by their end group were used to build self-assembled monolayers on gold substrates (SAM) that serve as templates for protein adsorption or covalent grafting. SAM surfaces before and after protein adsorption were characterized with a combination of techniques. Ex situ analysis were carried out, in air with polarization-modulated infr
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33

Stupfel, Marine. "Reconnaissance de surfaces de protéines par des foldamères aromatiques." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR14189/document.

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Les interactions protéine-protéine jouent un rôle primordial dans de nombreux processus biologiques. L’importance de ces interactions a suscité le développement de nouvelles approches thérapeutiques qui ciblent ces complexes protéiques. Nous nous proposons d’inhiber ces interactions en élaborant une stratégie de reconnaissance de surfaces de protéines par des molécules synthétiques de taille intermédiaire, les foldamères d’oligoquinoline. Ces composés se replient en des structures hélicoïdales stables dont chaque élément constitutif peut être fonctionnalisé pour permettre des propriétés de rec
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34

Du, Ying Jun. "PEO and PEO-heparin modified surfaces for blood contacting applications /." *McMaster only, 2001.

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35

Frasca, Stefano. "Biocatalysis on nanostructured surfaces : investigation and application of redox proteins using spectro-electrochemical methods." Phd thesis, Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2012/5813/.

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In this thesis, different aspects within the research field of protein spectro- and electro-chemistry on nanostructured materials are addressed. On the one hand, this work is related to the investigation of nanostructured transparent and conductive metal oxides as platform for the immobilization of electroactive enzymes. On the other hand the second part of this work is related to the immobilization of sulfite oxidase on gold nanoparticles modified electrode. Finally direct and mediated spectroelectrochemistry protein with high structure complexity such as the xanthine dehydrogenase from Rhodo
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36

Mughal, Muhammad Zeeshan. "Nano-patterning of hydrogenated amorphous carbon (a-C:H) surfaces for control of protein absorption." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603545.

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The thesis presents an investigation of the nano-patterning of hydrogenated amorphous carbon (a-C:H) surfaces to control protein adsorption. The relevant literature is first reviewed, noting the link between protein adsorption and mis-folding and its relevance to bio-compatibility and nano-toxicity. It then identifies how nano-topography influences protein adsorption, the debates and conflicts in the literature regarding this effect and the issues associated with controlling nanotopography independently of local surface composition. The first experimental chapter deals with the preparation and
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37

Allgor, Susan J. Sofia (Susan Jane Sofia). "Linear and star-shaped poly(ethylene oxide) grafted surfaces : grafting density and protein adsorption." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/38814.

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38

Ahl, Ing-Marie. "Protein Engineering of Extracellular Superoxide Dismutase : Characterization of Binding to Heparin and Cellular Surfaces." Doctoral thesis, Linköpings universitet, Cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-52452.

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Accumulating evidence indicates that oxygen free radicals are involved in many diseases and pathological conditions, such as aging, inflammation, reperfusion damage of ischemic tissue and various cardiovascular diseases. Extracellular superoxide dismutase (ECSOD) thus plays a major role in the maintenance of cells by providing protection against these toxic substances in the extracellular space. Various animal studies have shown that ECSOD has the ability to protect against many of these disorders, and interest has therefore evolved in the potential therapeutic use of the enzyme. However, desp
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39

Keselowsky, Benjamin George. "Engineering surfaces to direct integrin binding and signaling to promote osteoblast differentiation." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/8092.

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Cell adhesion to proteins adsorbed onto implanted surfaces is particularly important to host responses in biomedical and tissue engineering applications. Biomaterial surface properties influence the type, quantity and functional presentation (activity) of proteins adsorbed upon contact with physiological fluids, and modulate subsequent cell response. Cell adhesion to extracellular matrix proteins (e.g. fibronectin) is primarily mediated by the integrin family of cell-surface receptors. Integrins not only anchor cells, supporting cell spreading and migration, but also trigger signals that regul
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40

Wei, Shuai. "The Structure and Stability of Alpha-Helical, Orthogonal-Bundle Proteins on Surfaces." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2323.

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The interaction of proteins with surfaces is a major problem involved in protein microarrays. Understanding protein/surface interactions is key to improving the performance of protein microarrays, but current understanding of the behavior of proteins on surfaces is lacking. Prevailing theories on the subject, which suggest that proteins should be stabilized when tethered to surfaces, do not explain the experimentally observed fact that proteins are often denatured on surfaces. In an attempt to develop some predictive capabilities with respect to protein/surface interactions, it was asked in pr
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41

Samak, Mihir. "Role of Serum Albumin Aggregation in Lubrication and Wear Protection of Shearing Surfaces." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39403.

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Healthy articular joints exhibit remarkable lubrication due in large part to the complex rheological and tribological behavior of the synovial fluid (SF) that lubricates the joints. Current approaches that seek to elucidate such remarkable lubrication usually focus on the roles of high molecular weight SF components such as lubricin and hyaluronic acid but frequently overlook the role of serum albumin (SA), although it represents 90% of the protein content of SF. In this thesis, we used the Surface Forces Apparatus to investigate in detail the structural and tribological response of SA thin fi
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42

Joseph, Jerelle Aurelia. "Energy landscapes for protein folding." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284923.

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Proteins are involved in numerous functions in the human body, including chemical transport, molecular recognition, and catalysis. To perform their function most proteins must adopt a specific structure (often referred to as the folded structure). A microscopic description of folding is an important prerequisite for elucidating the underlying basis of protein misfolding and rational drug design. However, protein folding occurs on heterogeneous length and time scales, presenting a grand challenge to both experiments and simulations. In computer simulations, challenges are generally mitigated by
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43

Schweke, Hugo. "Développement d’une méthode in silico pour caractériser le potentiel d’interaction des surfaces protéiques dans un environnement encombré." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS554.

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Dans la cellule, les protéines évoluent dans un environnement très dense et interagissent ainsi avec un grand nombre de partenaires spécifiques et non-spécifiques qui entrent en compétition. L’objectif de ma thèse est de caractériser les propriétés physiques et évolutives des surfaces protéiques pour comprendre comment la pression de sélection s’exerce sur les protéines, façonnant leurs interactions et régulant ainsi cette sévère compétition.Pour cela, j’ai développé une méthodologie permettant de caractériser la propension des protéines à interagir avec les protéines de leur environnement, pa
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44

Doh, Junsang. "Immunological synapse arrays : patterned protein surfaces that modulate immunological synapse structure formation in T cells." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/35133.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2006.<br>Vita.<br>Includes bibliographical references (leaves 128-137).<br>T cells are activated by recognition of foreign peptides displayed on the surface of antigen presenting cells (APCs), an event that triggers assembly of a complex microscale structure at the T cell-APC interface known as the immunological synapse (IS). It remains unresolved whether the unique physical structure of the synapse itself impacts the functional response of T cells, independent of the quantity and quality of ligands encounte
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45

Buratto, Jeremie. "Reconnaissance de surfaces protéiques par des foldamères d'oligoamides aromatiques." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0003/document.

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Les interactions protéine - protéine sont au centre de nombreux processus biologiques, et représentent des cibles thérapeutiques pertinentes pour le traitement de certaines maladies. La conception de molécules antagonistes visant à inhiber ces interactions requiert la reconnaissance spécifique d’une des surfaces protéiques impliquées. Les foldamères de type oligoamides de quinoline constituent de bons candidats. Leur production et leur fonctionnalisation sont relativement aisées. Ils adoptent des structures hélicoïdales semblables à celles rencontrées dans les protéines. Grâce à différentes te
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46

Reuther, Cordula. "Patterning planar surfaces with motor proteins: Towards spatial control over motile microtubules." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-20916.

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A major challenge in nanotechnology is the spatially controlled transport of cargo on the nanometer scale. The use of a nanoscale transport system based on molecular motors and filaments of the cytoskeleton proved as a promising approach to this problem. Therefore, the objective of this work was to pattern planar surfaces with motor proteins in a way that allows controlled and guided movement of microtubule-shuttles. The first part of the work was in particular focused on generating nanometer–sized tracks of motor proteins on unstructured surfaces. Specifically, microtubules themselves were us
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47

White, Andrew John. "The biophysical chemistry of tooth surfaces : protein and peptide-based technologies for inhibiting erosive tooth wear." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550331.

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Dental erosion is an increasing problem in many countries around the world, and research in this field has increased dramatically in recent years. Dental erosion is the dissolution of tooth tissues by acids that are not of bacterial origin; most commonly these originate from the diet. Methods to reduce erosion are of great import; the application of milk-derived proteins such as casein and casein-derived proteins are of current interest as anti-erosion agents and are the subject of the work presented here in this thesis. The efficacy of casein and casein-derived proteins as agents to inhibit d
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48

Yang, Zhugen. "3D-Microstructured Protein Chip for Cancer Diagnosis." Phd thesis, Ecole Centrale de Lyon, 2012. http://tel.archives-ouvertes.fr/tel-00780192.

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Protein microarrays are becoming powerful tools to screen and identify tumor markers for cancer diagnosis, because of the multiplex detection and minute volume of sample requirement. Due to the diversity and variation in different cancers, no single tumor marker is sensitive and specific enough to meet strict diagnostic criteria. Therefore, a combination of tumor markers is required to increase sensitivity and to establish distinct patterns to increase specificity. To obtain reliable tests, the development of reproducible surface chemistry and immobilization procedure are crucial steps in the
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49

Zhang, Xiaoyuan [Verfasser], Klaus D. [Gutachter] Jandt, Jürgen [Gutachter] Geis-Gerstorfer, and Ben [Gutachter] Fabry. "Protein adsorption on nanostructured polymer surfaces / Xiaoyuan Zhang ; Gutachter: Klaus D. Jandt, Jürgen Geis-Gerstorfer, Ben Fabry." Jena : Friedrich-Schiller-Universität Jena, 2019. http://d-nb.info/1207271500/34.

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Chouchane, Karim. "Contrôler l'agrégation de l'insuline à la surface des matériaux via des interactions avec des peptides et la lumière." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAY072/document.

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Abstract:
Le repliement et la stabilité des protéines dépendent des conditions physico-chimiques de leur environnement. En particulier, le pH, la température, l’agitation et les interactions avec d’autres macromolécules ou avec les interfaces (liquide–surfaces des matériaux ; air-liquide ; etc.) sont connues pour induire des phénomènes de dénaturation et d’agrégation des protéines.Le contrôle de la stabilité des protéines thérapeutiques représente un enjeu médical et économique pour l’industrie pharmaceutique. L’insuline, qui est la protéine thérapeutique la plus produite, est connue in vitro pour forme
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