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Dissertations / Theses on the topic 'Proteína 14-3-3'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Assato, Patricia Akemi. "Estudo das interações moleculares da proteína 14-3-3 de Paraoccidioides brasiliensis /." Araraquara, 2018. http://hdl.handle.net/11449/154960.

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Orientador: Ana Marisa Fusco-Almeida<br>Coorientador: Andrei Munhoz<br>Banca: Juliana Barbosa Coitinho Gonçalves<br>Banca: Julhiany de Fátima da Silva<br>Banca: Juliana Campos Junqueira<br>Banca: Maria Célia Bertolini<br>Resumo: Paracoccidioides brasiliensis é um dos agentes etiológicos da paracoccidioidomicose, micose sistêmica de grande importância na América Latina devido a incidência. Durante a interação com o hospedeiro, P. brasiliensis sintetiza diversas moléculas que auxiliam no processo infeccioso, entre elas, a proteína Pb14-3-3 desempenha um importante papel no estabelecimento da inf

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2

Silva, Julhiany de Fátima da [UNESP]. "Clonagem e caracterização da proteína 14-3-3 de Paracoccidioides brasiliensis durante sua interação com células epiteliais." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/103860.

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Made available in DSpace on 2014-06-11T19:32:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-11-18Bitstream added on 2014-06-13T19:03:35Z : No. of bitstreams: 1 silva_jf_dr_arafcf.pdf: 9310413 bytes, checksum: fb67253daf71a3dc5fdaa805159dff93 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Universidade Estadual Paulista (UNESP)<br>A paracoccidioidomicose (PCM) é micose sistêmica causada pelos fungos dimórficos Paracoccidioides brasiliensis (espécies cripticas S1, PS2, PS3) e Paracoccidioides lutzii (Pb01-like espécies), endêmica na América Latina,

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3

Silva, Julhiany de Fátima da. "Clonagem e caracterização da proteína 14-3-3 de Paracoccidioides brasiliensis durante sua interação com células epiteliais /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/103860.

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Resumo: A paracoccidioidomicose (PCM) é micose sistêmica causada pelos fungos dimórficos Paracoccidioides brasiliensis (espécies cripticas S1, PS2, PS3) e Paracoccidioides lutzii (Pb01-like espécies), endêmica na América Latina, principalmente no Brasil. A capacidade de causar micose com grande variedade de manifestações clínicas, desde formas localizadas até doença disseminada evoluindo para letalidade, depende da virulência do fungo e de sua habilidade em interagir com as estruturas superficiais do hospedeiro e invadi-las, e a resposta imunológica deste último. P. brasiliensis tem a capacida

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4

Spoladore, Larissa. "Componentes genéticos que afetam a via de direcionamento de proteínas organelares em Arabidopsis thaliana." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/11/11151/tde-27062016-094405/.

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Nos eucariotos, a evolução dos sistemas de transporte molecular foi essencial pois seu alto grau de compartimentalização requer mecanismos com maior especificidade para a localização de proteínas. Com o estabelecimento das mitocôndrias e plastídeos como organelas da célula eucariota, grande parte dos genes específicos para sua atividade e manutenção foram transferidos ao núcleo. Após a transferência gênica, a maioria das proteínas passaram a ser codificadas pelo núcleo, sintetizadas no citosol e direcionadas às organelas por uma maquinaria complexa que envolve receptores nas membranas das orga

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5

Teichmann, Aline. "Clonagem e expressão da proteína 14-3-3ε1 de Echinococcus granulosus em Escherichia coli". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/30207.

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O Echinococcus granulosus é um platelminto parasita da classe Cestoda, que tem, como hospedeiros definitivos, os canídeos, e, como hospedeiros intermediários mais comuns, ungulados domésticos e o homem. Este parasito é o agente etiológico da hidatidose cística, zoonose hiperendêmica no Cone Sul da América do Sul, incluindo o sul do Brasil. Para o estabelecimento e manutenção do cisto hidático por longos períodos de tempo (infecção crônica), o parasito secreta e expõe ao seu hospedeiro numerosas proteínas, que podem apresentar tanto atividade imunomoduladora, como estar relacionadas a atividade

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6

Assato, Patricia Akemi. "Análise funcional da proteína 14-3-3 de Paracoccidioides brasiliensis e prospecção de alvos terapêuticos inibidores da interação de P. brasiliensis à pneumócitos /." Araraquara, 2014. http://hdl.handle.net/11449/123660.

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Orientador: Ana Marisa Fusco Almeida<br>Coorientador: Cleslei Fernando Zanelli<br>Banca: Carlos Peleschi Taborda<br>Banca: Cristiano Gallina Moreira<br>Resumo: Paracoccidiodomicose (PCM) é uma micose sistêmica endêmica na América Latina, de alta prevalência no Brasil, que tem como agente etiológico os fungos dimórficos do gênero Paracoccidioides, P. brasiliensis e P. lutzii. No processo de infecção as adesinas, substâncias sintetizadas por estes fungos que se ligam a matriz extracelular, são importantes fatores de virulência para o estabelecimento da infecção. A proteína de 30kDa, pertencente

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7

Assato, Patricia Akemi [UNESP]. "Análise funcional da proteína 14-3-3 de Paracoccidioides brasiliensis e prospecção de alvos terapêuticos inibidores da interação de P. brasiliensis à pneumócitos." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123660.

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Made available in DSpace on 2015-06-17T19:33:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-07-11. Added 1 bitstream(s) on 2015-06-18T12:48:23Z : No. of bitstreams: 1 000832029.pdf: 1345027 bytes, checksum: 6207079d0ab94cde1a6d3a7db40846f6 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Paracoccidiodomicose (PCM) é uma micose sistêmica endêmica na América Latina, de alta prevalência no Brasil, que tem como agente etiológico os fungos dimórficos do gênero Paracoccidioides, P. brasiliens

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8

Castelló, Llopis María José. "Identificación y caracterización de la familia de factores DBP, nuevos reguladores de la expresión génica en plantas." Doctoral thesis, Universitat Politècnica de València, 2009. http://hdl.handle.net/10251/6363.

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El factor de transcripción DBP1 de Nicotiana tabacum, es el primer miembro de una nueva familia de reguladores transcripcionales que poseen, además de capacidad de unión al ADN, actividad proteín-fosfatasa de tipo 2C. En este trabajo hemos abordado la caracterización funcional del factor regulador DBP1, determinando que su capacidad de unión al ADN reside en el motivo DNC, el cual se localiza en la región N-terminal de la proteína y está conservado entre las proteínas DBP de diferentes plantas mono y dicotiledóneas. Así mismo hemos llevado a cabo una búsqueda de factores proteicos que interacc

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9

Brown, Andrew Peter. "Functional specificity of 14-3-3 proteins from tomato." Thesis, Lancaster University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436736.

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10

Brechin, C. "14-3-3 proteins and cholesterol-dependent membrane domains." Thesis, University of Edinburgh, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.641914.

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In this thesis I set out to characterise the interaction of 14-3-3 with lipid raft-like membrane domains. 14-3-3 associated with DRMs isolated from rate brain extract in a 14-3-3 isoform specific manner. Inhibition of 14-3-3 target protein interactions suggested that this association was reliant on binding of 14-3-3 to a membrane protein. The interaction of 14-3-3 with DRMs was further investigated in N2a and PC12 cells and also be detergent-free method. There are, however, some concerns over whether DRMs represent physiological membrane domains. Therefore I also investigated quantitatively th

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11

Milton, Alasdair Hugh. "The regulation of E2F by 14-3-3 proteins." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439225.

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12

Kent, Christopher. "14-3-3 proteins regulate axonal growth cone turning repsonses." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114302.

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The extension of axons to their appropriate targets during development or regeneration relies on the growth cone, a specialized structure that integrates extracellular signals to guide axon growth. Achieving the many complex connections formed by the nervous system while relying on a limited number of cues, requires the growth cone to modulate its response to signals in both space and time. The mechanisms by which the growth cone is able to spatially and temporally regulate its underlying cytoskeletal response to guidance cues are only beginning to become understood. Proteomic analysis of isol

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13

Stevenson, Ross. "Specific detection of 14-3-3 proteins by ssDNA aptamers." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/11427.

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A library of ssDNA aptamers has been screened and a number of molecules which show high binding affinity to 14-3-3 proteins have been isolated. The gene encoding mammalian 14-3-3 γ modified by (his)<sub>6</sub> tagging, was overexpressed in <i>E. coli </i>and purified to homogeneity. The recombinant 14-3-3 γ was characterised using a series of techniques ensuring that the expressed protein had similar physical and immunological characteristics to that of wild type 14-3-3 γ. An ssDNA aptamer library was synthesised and aptamers selected following an adapted SELEX (systematic evolution of ligand

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14

DeLille, Justin Marcus. "Diverse localization of 14-3-3 proteins in Arabidopsis thaliana." [Gainesville, Fla.] : University of Florida, 2001. http://etd.fcla.edu/etd/uf/2001/anp1597/master.PDF.

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Thesis (M.S.)--University of Florida, 2001.<br>Title from first page of PDF file. Document formatted into pages; contains viii, 131 p.; also contains graphics. Vita. Includes bibliographical references (p. 126-130).

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15

Brechin, Carolyn. "SNAREs, 14-3-3 proteins and cholesterol dependent membrane domains." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29276.

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Lipid rafts are suggested to be sphingolipid and cholesterol rich domains that segregate out from the bulk plasma membrane by forming a more ordered lipid phase. Lipid raft-like domains have been described as cell signalling platforms and have been implicated in the regulation of an array of signal transduction events. This study investigates the association of two classes of protein, 14-3-3 proteins and plasma membrane SNAREs, with lipid raft-like domains. The 14-3-3 family of proteins are important regulators of numerous cell signalling pathways and are essential for cell survival; recently

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16

Yeung, Shu-wai. "Analysis of 14-3-3 [sigma] protein in nasopharyngeal tissues." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971398.

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17

Yasmin, Lubna. "Exoenzyme S of Pseudomonas aeruginosa : cellular targets and interaction with 14-3-3." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1411.

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18

楊舒瑋 and Shu-wai Yeung. "Analysis of 14-3-3 [sigma] protein in nasopharyngeal tissues." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31971398.

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19

Fuller, Brian Frederick. "Proteomic study of the 14-3-3 proteins in Arabidopsis thaliana." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011836.

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20

Vasara, Tuija. "Functional analysis of the RHOIII and 14-3-3 proteins of Trichoderma reesei /." Espoo [Finland] : Technical Research Centre of Finland, 2002. http://www.vtt.fi/inf/pdf/publications/2002/P466.pdf.

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21

LeBron, Cynthia. "Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0001992.

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22

Yilmaz, Elvan [Verfasser], and Markus [Akademischer Betreuer] Kaiser. "Supramolekulare Liganden für 14-3-3-Proteine / Elvan Yilmaz ; Betreuer: Markus Kaiser." Duisburg, 2018. http://d-nb.info/1161341471/34.

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23

Alexander, Ross. "An analysis of 14-3-3 binding proteins from developing barley grains." Thesis, Heriot-Watt University, 2006. http://hdl.handle.net/10399/159.

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24

Bertolino, Lígia Tereza. "Estudo das Proteínas 14-3-3A e 14-3-3D de Nicotiana tabacum L. e seu Papel no Desenvolvimento Floral." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-21052014-113419/.

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A modulação da forma e tamanho em órgãos vegetais depende do controle temporal e espacial de divisão e expansão celular. Entretanto, pouco se sabe a respeito dos mecanismos moleculares que regulam este processo durante o desenvolvimento floral. O estudo da via de sinalização de SCI1 (Stigma/style Cell Cycle Inhibitor 1) pode contribuir para o entendimento do processo de crescimento das flores. Este gene produz uma proteína, localizada no nucléolo, que está relacionada à inibição da proliferação celular no estigma e no estilete de Nicotiana tabacum, modulando o tamanho destes órgãos florais. Ex

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Marcos, Caroline Maria [UNESP]. "Funcionalidade das proteínas EF-Tu e 14-3-3 na virulência de Paracoccidioides brasiliensis." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/132196.

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Made available in DSpace on 2015-12-10T14:24:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-04-30. Added 1 bitstream(s) on 2015-12-10T14:30:44Z : No. of bitstreams: 1 000851710_20160722.pdf: 735546 bytes, checksum: 011c591d928a97fba211a8ca067ba722 (MD5) Bitstreams deleted on 2016-07-25T13:17:40Z: 000851710_20160722.pdf,. Added 1 bitstream(s) on 2016-07-25T13:18:47Z : No. of bitstreams: 1 000851710.pdf: 5518013 bytes, checksum: 8a378cf5a8a0a17841f43b423f397e01 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Coordenação de Aperfeiçoamento de Pessoal de N

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Marcos, Caroline Maria. "Funcionalidade das proteínas EF-Tu e 14-3-3 na virulência de Paracoccidioides brasiliensis /." Araraquara, 2015. http://hdl.handle.net/11449/132196.

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Orientador : Ana Marisa Fusco Almeida<br>Coorientador: Maria José Soares Mendes Giannini<br>Banca: Eduardo Bagagli<br>Banca: Alexandra Ivo de Medeiros<br>Banca: Márcia Regina von Zeska Kress<br>Banca: Angela Maria Victoriano de Cmpos Soares<br>Resumo: Paracoccidioides brasiliensis é o agente causador da paracoccidioidomicose (PCM), micose sistêmica com ampla distribuição na América Latina. A adesão e invasão de células do hospedeiro são eventos cruciais envolvidos na infecção e disseminação do patógeno. Além disso, estes utilizam suas moléculas de superfície para se ligar aos componentes da ma

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Teichmann, Aline. "Caracterização das proteínas 14-3-3 expressas na fase larval patogênica de Echinococcus spp." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/117914.

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A família de proteínas 14-3-3 as quais desempenham funções reguladoras conservadas foi estudada em parasitos do gênero Echinococcus, agentes causadores de diferentes formas de hidatidose. Nos genomas de Echinococcus granulosus e de Echinococcus multilocularis seis isoformas foram encontradas (Eg14-3-3.1-6 e Em14-3-3.1-6, respectivamente) com sequências e estruturas conservadas entre ortólogos. As estruturas gene/proteína de 14-3-3 de E. granulosus e de E. multilocularis foram analisadas e as relações filogenéticas com proteínas ortólogas foram estabelecidas para uma ampla gama de espécies. As

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Throm, Christian [Verfasser]. "Identifizierung und Charakterisierung von „NON-PHOTOTROPIC HYPOCOTYL 3“ als neuartiger Interaktionspartner pflanzlicher 14-3-3 Proteine / Christian Throm." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1227596235/34.

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Liu, Natalie, Charles W. Putnam, and Jesse D. Martinez. "Modeling Cell Cycle Effects of Human 14-3-3 Tumor Promoting Proteins in Saccharomyces Cerevisiae." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/244407.

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In this study, we used budding yeast as a model organism to examine the effects of overexpression of Bmh1, a yeast homolog of 14-3-3γ. We found that in the presence of modest DNA damage, Bmh1 overexpression had its most prominent effect during G2/M-phase of the cell cycle. We also observed that overexpression of Bmh1 concurrent with the induction of DNA damage partially rescued the G2/M arrest defect caused by the absence of Rad9, a key component of the G2/M DNA damage checkpoint pathway. When RAD53, a gene in the "Rad53 pathway" of the G2/M checkpoint, was deleted, overexpression of Bmh1 had

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Collins, Daniel M. "Functional interactions of 14-3-3 proteins with phospholipase D and the M₃ muscarinic receptor." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/24471.

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14-3-3 proteins are a family of small, acidic, scaffolding and adaptor proteins, which have been implicated in cell cycle regulation, apoptosis and signal transduction mechanisms. There are seven isoforms of 14-3-3 (β, η, γ, ε, τ/θ, σ, and ζ) that form hetero-and homodimers <i>in vivo</i>. Recently, 14-3-3 has been shown to associate with members of the heptahelical, plasma membrane spanning G-protein coupled receptor (GPCR) superfamily. GPCRs mediate neurotransmitter and other extracellular agonist-evoked activation of intracellular effectors and signalling cascades. Some of these effector me

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Santoro, Massimo M. "The binding of 14-3-3 proteins to the Ron receptor is required for its biological activity." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342901.

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Vargas, Daiani Machado de. "Caracterização das proteínas 14-3-3ζ expressas na fase larval de Echinococcus granulosus". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/84963.

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As proteínas 14-3-3 formam uma família altamente conservada, expressas em todos os organismos eucariotos já estudados. Através da interação com seus alvos, as proteínas 14-3-3 participam de importantes processos celulares, como controle do ciclo celular, apoptose, transdução de sinal e diferenciação celular. Neste trabalho, essa família gênica foi estudada em Echinococcus granulosus e em Echinococcus multilocularis, as espécies de maior importância do gênero Echinococcus. E. granulosus e E. multilocularis, na fase larval, são agentes etiológicos da hidatidose cística e da hidatidose alveolar,

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Schröder, Markus [Verfasser]. "Interactions of the adaptor proteins AP2 and 14-3-3 with the presynaptic scaffolding protein Bassoon / Markus Schröder." Magdeburg : Universitätsbibliothek, 2015. http://d-nb.info/1075547520/34.

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Reetoo, Namrata. "Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway." Thesis, University of Dundee, 2012. https://discovery.dundee.ac.uk/en/studentTheses/b725a974-2bcf-4af1-998e-69cb4dfe7d61.

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McLean, Julie B. "Tumor-derived proteins and mitochondrial dysfunction in lung cancer-induced cachexia." UKnowledge, 2015. http://uknowledge.uky.edu/physiology_etds/21.

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Lung tumors secrete multiple factors that contribute to cachexia, a severe wasting syndrome that includes loss of muscle mass, weakness, and fatigue. 80% of advanced lung cancer patients experience cachexia, which cannot be reversed by nutritional interventions, diminishes response to and tolerance of cancer treatments, and increases morbidity and mortality. Despite a multitude of clinical trials, there are currently no approved treatments. This deficiency suggests that not all of the factors that contribute to cachexia have been identified. Cancer is frequently accompanied by an increase in c

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Houston, Nicola Patricia. "Protein complexes in neurodegenerative diseases." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7738.

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The 14-3-3 family of proteins are important signalling proteins involved in a number of cellular processes. These include cell cycle regulation, apoptosis, signal transduction and cell signalling. There is also considerable evidence in the literature that 14-3-3 proteins play a vital role in the pathology of neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s and Prion disease. The neurodegenerative disease of focus in this research is Spinocerebellar Ataxia Type 1 (SCA1). SCA1 is a polyglutamine-repeat disease and the interaction of the disease protein ataxin-1 with 1

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Snow, Alan J. "Phosphorylation-dependent interaction of tyrosine 3 monooxygenase/tryptophan 5-monooxygenase activation protein (14-3-3) with PADI6 following oocyte maturation in mice." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1208796428.

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Thesis (Ph.D.)--Kent State University, 2008.<br>Title from PDF t.p. (viewed May 26, 2009). Advisor: Douglas W. Kline. Keywords: oocyte, egg, ovum, PADI6, PAD6, 14-3-3, peptidylarginine deiminase, phosphorylation, mouse, oocyte maturation, gamete biology. Includes bibliographical references (p. 91-97).

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Kilisch, Markus. "Quantitative analysis of protein-protein interactions governing TASK-1/TASK-3 intracellular transport." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-87D8-0.

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Papon, Marie-Amélie. "Régulation des sous-types d’hétérodimères du récepteur GABAB dans la moelle épinière en conditions de douleurs neuropathiques : rôle des protéines partenaires." Thesis, Bordeaux 2, 2009. http://www.theses.fr/2009BOR21671/document.

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Dans le système nerveux central, le récepteur inhibiteur GABAB est un archétype des RCPGs hétérodimériques. Il est composé en effet de deux sous-unités, la sous-unité GABAB1 (B1a ou B1b) qui lie l’agoniste et la sous-unité GABAB2 couplée aux protéines G. L’activation de ce récepteur a un effet antinociceptif bien établi concernant les douleurs aiguës mais son effet reste cependant très limité en cas de douleurs neuropathiques. Notre hypothèse est que son activation et sa signalisation peuvent être altérées par des protéines partenaires, aboutissant à des processus de désinhibition dans la moel

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Morgan, Lindsay Dawn. "A characterisation and functional analysis of the role of the 14-3-3-like proteins in neuronal ageing in the pond snail, Lymnaea stagnalis." Thesis, University of Brighton, 2012. https://research.brighton.ac.uk/en/studentTheses/e356047e-62f2-4905-bcef-c995044ceb44.

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14-3-3 proteins are a ubiquitous family known for their ability to regulate myriad cellular processes including lifespan, neuronal signalling and transduction, protein trafficking and transmitter production and release. Previous work has shown that 14-3-3 proteins are linked to a variety of pathological neurodegenerative diseases although their role in healthy brain ageing is currently unclear. This study utilised the pond snail, Lymnaea stagnalis to examine the contribution made by 14-3-3 to the decrease in feeding rate that is seen in this model system with age. Interrogation of a Lymnaea CN

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Aristizábal, Corrales David. "Cell cycle checkpoints in Caenorhabditis elegans: the 14-3-3 gene par-5 is required for germline development and DNA damage response / Checkpoints del ciclo celular en Caenorhabditis elegans: el gen 14-3-3, par-5, es necesario para el desarrollo y respuesta al daño genómico de la línea germinal." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83321.

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14-3-3 proteins have been extensively studied from yeast to mammals, and are associated with multiple roles ranging from fundamental processes such as cell cycle, apoptosis and stress response to diseases such as neurodegeneration and cancer. Indeed, 14-3-3 proteins have been suggested as possible therapeutic targets in cancer treatment. There are seven 14-3-3 genes in mammals, whereas there are only two in Caenorhabditis elegans, ftt-2 and par-5. The ftt-2 gene is expressed only in somatic lineages, whereas par-5 expression is detected in both soma and germline. Although it is known that par-

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Lo, Kin Ho. "Activation of signal transducer and activator of transcription 3 (STAT3) by G[alpha]16 and G[alpha]14 via a c-Src/JAK-and ERK-dependent mechanism /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20LO.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2004.<br>Includes bibliographical references (leaves 92-111). Also available in electronic version. Access restricted to campus users.

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Nickel, Philipp [Verfasser], Markus [Akademischer Betreuer] Kaiser, Christian [Akademischer Betreuer] Ottmann, and Peter [Akademischer Betreuer] Bayer. "Design und Synthese von naturstoffbasierten chemischen Sonden und rational-entworfenen Wirkstoffen für 14-3-3 Adapter-Proteine / Philipp Nickel. Gutachter: Christian Ottmann ; Peter Bayer. Betreuer: Markus Kaiser." Duisburg, 2013. http://d-nb.info/1033504432/34.

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Westin, Maria Cristina do Amaral 1949. "Expressão das proteínas MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 e VEGF-A na NIC 3 e no carcinoma invasor do colo do útero = Expression of the proteins MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 and VEGF-A in the CIN 3 and cervical cancer." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313599.

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Orientadores: Luiz Carlos Zeferino, Silvia Helena Rabelo dos Santos<br>Texto em português e inglês<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-23T06:30:30Z (GMT). No. of bitstreams: 1 Westin_MariaCristinadoAmaral_D.pdf: 3122088 bytes, checksum: 3d2afed3690cd3566bbb3fe26bb492a3 (MD5) Previous issue date: 2013<br>Resumo: Introdução: O carcinoma escamoso do colo uterino é precedido pela neoplasia intraepitelial cervical grau 3 (NIC 3). A invasão tumoral envolve a degradação da matriz extracelular e membrana basal

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Kanatani, Sachie. "Host-parasite interactions in the dissemination of Toxoplasma gondii." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-148573.

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Toxoplasma gondii is an obligate intracellular parasite that infects virtually all warm-blooded organisms. Systemic dissemination of T. gondii in the organism can cause life-threatening infection that manifests as Toxoplasma encephalitis in immune-compromised patients. In addition, mounting evidence from epidemiological studies indicates a link between chronic Toxoplasma infection and mental disorders. To better understand the pathogenesis of toxoplasmosis, basic knowledge on the host-parasite interactions and the dissemination mechanisms are essential. Previous findings have established that,

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Henriksson, Maria. "Cellular targets of Pseudomonas aeruginosa toxin Exoenzyme S." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-121.

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Magrlová, Lucie. "Studium interakce 14-3-3 proteinu s proteiny rodiny phosducinů." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-281264.

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Bártová, Hana. "Exprese a purifikace kinasove domény ASK1 kinasy." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-285135.

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The goal of this diploma thesis was to find optimal conditions for expression of ASK1 kinase in prokaryotic expression system and to optimize purification protocol which enables preparing of milligram amounts of stable and soluble protein. Different conditions of expression were tested in E. coli cells including temperature of expression, cultivation medium or the length of induction. Different methods of purification were tested during the development of the purification protocol. The final protocol is based on chelate chromatography followed by gel permeation chromatography. The result of th

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Šilhán, Jan. "Studium molekulárních mechanismů funkce 14-3-3 proteinů." Doctoral thesis, 2009. http://www.nusl.cz/ntk/nusl-379312.

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Závěr Hlavním cílem této doktorské práce bylo objasnění molekulárních mechanismů funkce 14-3-3 proteinů a vlivu na proteiny FOXO4 a tyrosinhydroxylasu. V první časti této práce (publikace I) byla potvrzena předložená hypotéza polohy Cterminálního konce molekuly 14-3-3. Bylo ukázáno, že v nepřítomnosti ligandu se Cterminální konec nachází ve vazebném místě a brání tak vstupu ligandů. Po vazbě fosforylovaných ligandů, dochází k velmi silné vazbě a vytěsnění C-terminálního konce 14-3- 3 proteinu z vazebného místa. Tyto výsledky jsou v souladu s původními pracemi, které navrhly důležitost tohoto s

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Lentini, Santo Domenico. "Studium struktury komplexů proteinů 14-3-3 a jejich stabilizace nízkomolekulárními látkami." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-445781.

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Protein-protein interactions (PPIs) play a crucial role in almost all biological processes. Many proteins require a number of dynamic interactions with other proteins and/or biomolecules to function. Proteomic studies have suggested that human protein-protein interactome consists of several hundred thousands of protein complexes. A detailed insight into these PPIs is essential for a complete understanding of the processes mediated by these protein complexes. Because many PPIs are involved in disease-related signaling pathways, such PPIs are important targets for pharmaceutical interventions, e

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