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Journal articles on the topic 'Proteina quinasa'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 April 2022

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1

Pérez, Katherine, Carlos Elías, and Víctor Delgado. "High-protein snack: an extruded from quinoa (Chenopodium quinoa Willd.), tarwi (Lupinus mutabilis Sweet), and sweet potato (Ipomoea batatas L.)." Scientia Agropecuaria 8, no. 4 (2017): 377–88. http://dx.doi.org/10.17268/sci.agropecu.2017.04.09.

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2

Boonjakuakul, Jenni K., Helen L. Gerns, Yu-Ting Chen, et al. "Proteomic and Immunoblot Analyses of Bartonella quintana Total Membrane Proteins Identify Antigens Recognized by Sera from Infected Patients." Infection and Immunity 75, no. 5 (2007): 2548–61. http://dx.doi.org/10.1128/iai.01974-06.

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ABSTRACT Bartonella quintana is a fastidious, gram-negative, rod-shaped bacterium that causes prolonged bacteremia in immunocompetent humans and severe infections in immunocompromised individuals. We sought to define the outer membrane subproteome of B. quintana in order to obtain insight into the biology and pathogenesis of this emerging pathogen and to identify the predominant B. quintana antigens targeted by the human immune system during infection. We isolated the total membrane proteins of B. quintana and identified 60 proteins by two-dimensional sodium dodecyl sulfate-polyacrylamide gel

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3

Schulte, Berit, Dirk Linke, Sandra Klumpp, et al. "Bartonella quintana Variably Expressed Outer Membrane Proteins Mediate Vascular Endothelial Growth Factor Secretion but Not Host Cell Adherence." Infection and Immunity 74, no. 9 (2006): 5003–13. http://dx.doi.org/10.1128/iai.00663-06.

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ABSTRACT Bartonella quintana causes trench fever, endocarditis, and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis in humans. Little is known about the interaction of this pathogen with host cells. We attempted to elucidate the interaction of B. quintana with human macrophages (THP-1) and epithelial cells (HeLa 229). Remarkably, only B. quintana strain JK-31 induced secretion of vascular endothelial growth factor (VEGF) from THP-1 and HeLa 229 cells upon infection similar to the secretion induced by B. henselae Marseille, whereas other strains (B. quintana 2-D70

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4

Kalač, P., and J. Moudrý. "Composition and nutritinal value of quinoa (Chenopodium quinoa) – a review." Czech Journal of Food Sciences 18, No. 3 (2000): 115–19. http://dx.doi.org/10.17221/8322-cjfs.

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Literature data on proteins, lipids, starch, minerals, vitamins and saponins contents and composition and their distribution within whole quinoa seeds, hulls, bran and flour are reviewed. An information on effects of quinoa processing on nutritional value and food applications is also given.

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Monteith, William B., Rachel D. Cohen, Austin E. Smith, Emilio Guzman-Cisneros, and Gary J. Pielak. "Quinary structure modulates protein stability in cells." Proceedings of the National Academy of Sciences 112, no. 6 (2015): 1739–42. http://dx.doi.org/10.1073/pnas.1417415112.

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Protein quinary interactions organize the cellular interior and its metabolism. Although the interactions stabilizing secondary, tertiary, and quaternary protein structure are well defined, details about the protein–matrix contacts that comprise quinary structure remain elusive. This gap exists because proteins function in the crowded cellular environment, but are traditionally studied in simple buffered solutions. We use NMR-detected H/D exchange to quantify quinary interactions between the B1 domain of protein G and the cytosol of Escherichia coli. We demonstrate that a surface mutation in t

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Mu, Xin, Seongil Choi, Lisa Lang, et al. "Physicochemical code for quinary protein interactions inEscherichia coli." Proceedings of the National Academy of Sciences 114, no. 23 (2017): E4556—E4563. http://dx.doi.org/10.1073/pnas.1621227114.

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How proteins sense and navigate the cellular interior to find their functional partners remains poorly understood. An intriguing aspect of this search is that it relies on diffusive encounters with the crowded cellular background, made up of protein surfaces that are largely nonconserved. The question is then if/how this protein search is amenable to selection and biological control. To shed light on this issue, we examined the motions of three evolutionary divergent proteins in theEscherichia colicytoplasm by in-cell NMR. The results show that the diffusive in-cell motions, after all, follow

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MacKichan, Joanna K., Helen L. Gerns, Yu-Ting Chen, Peng Zhang, and Jane E. Koehler. "A SacB Mutagenesis Strategy Reveals that the Bartonella quintana Variably Expressed Outer Membrane Proteins Are Required for Bloodstream Infection of the Host." Infection and Immunity 76, no. 2 (2007): 788–95. http://dx.doi.org/10.1128/iai.01174-07.

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ABSTRACT Bartonella bacteria adhere to erythrocytes and persistently infect the mammalian bloodstream. We previously identified four highly conserved Bartonella quintana adhesin genes that undergo phase variation during prolonged bloodstream infection. The variably expressed outer membrane proteins (Vomp) encoded by these genes are members of the trimeric autotransporter adhesin family. Each B. quintana Vomp appears to contribute a different adhesion phenotype, likely mediated by the major variable region at the adhesive tip of each Vomp. Although studies document that the Vomp adhesins confer

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8

Lee, Dahae, Jin Su Lee, Jurdas Sezirahiga, Hak Cheol Kwon, Dae Sik Jang, and Ki Sung Kang. "Bioactive Phytochemicals Isolated from Akebia quinata Enhances Glucose-Stimulated Insulin Secretion by Inducing PDX-1." Plants 9, no. 9 (2020): 1087. http://dx.doi.org/10.3390/plants9091087.

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Chocolate vine (Akebia quinata) is consumed as a fruit and is also used in traditional medicine. In order to identify the bioactive components of A. quinata, a phytosterol glucoside stigmasterol-3-O-β-d-glucoside (1), three triterpenoids maslinic acid (2), scutellaric acid (3), and hederagenin (4), and three triterpenoidal saponins akebia saponin PA (5), hederacoside C (6), and hederacolchiside F (7) were isolated from a 70% EtOH extract of the fruits of A. quinata (AKQU). The chemical structures of isolates 1–7 were determined by analyzing the 1D and 2D nuclear magnetic resonance (NMR) spectr

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9

Burz, David, Leonard Breindel, and Alexander Shekhtman. "The Inescapable Effects of Ribosomes on In-Cell NMR Spectroscopy and the Implications for Regulation of Biological Activity." International Journal of Molecular Sciences 20, no. 6 (2019): 1297. http://dx.doi.org/10.3390/ijms20061297.

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The effects of RNA on in-cell NMR spectroscopy and ribosomes on the kinetic activity of several metabolic enzymes are reviewed. Quinary interactions between labelled target proteins and RNA broaden in-cell NMR spectra yielding apparent megadalton molecular weights in-cell. The in-cell spectra can be resolved by using cross relaxation-induced polarization transfer (CRINEPT), heteronuclear multiple quantum coherence (HMQC), transverse relaxation-optimized, NMR spectroscopy (TROSY). The effect is reproduced in vitro by using reconstituted total cellular RNA and purified ribosome preparations. Fur

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10

Carroll, James A., Sherry A. Coleman, Laura S. Smitherman, and Michael F. Minnick. "Hemin-Binding Surface Protein fromBartonella quintana." Infection and Immunity 68, no. 12 (2000): 6750–57. http://dx.doi.org/10.1128/iai.68.12.6750-6757.2000.

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ABSTRACT Bartonella quintana, the agent of trench fever and a cause of endocarditis and bacillary angiomatosis in humans, has the highest reported in vitro hemin requirement for any bacterium. We determined that eight membrane-associated proteins from B. quintana bind hemin and that a ∼25-kDa protein (HbpA) was the dominant hemin-binding protein. Like many outer membrane proteins, HbpA partitions to the detergent phase of a Triton X-114 extract of the cell and is heat modifiable, displaying an apparent molecular mass shift from approximately 25 to 30 kDa when solubilized at 100°C. Immunoblots

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11

Schaan, Beatriz D. "O papel da proteína quinase C no desenvolvimento das complicações vasculares do diabetes mellitus." Arquivos Brasileiros de Endocrinologia & Metabologia 47, no. 6 (2003): 654–62. http://dx.doi.org/10.1590/s0004-27302003000600006.

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A mortalidade dos pacientes com diabetes (DM) é maior do que a da população em geral e decorre especialmente das doenças cardiovasculares. Os prováveis mecanismos da aterosclerose acelerada nestes pacientes são os efeitos tóxicos diretos da glicose sobre a vasculatura, a resistência à insulina e a associação do DM a outros fatores de risco para doença cardiovascular. O principal determinante do dano tecidual causado pelo DM é a hiperglicemia, resultando em aumento de glicose intra-celular, aumento de diacilglicerol (DAG) e ativação da proteína quinase C (PKC). Esta revisão tem por objetivo com

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12

Gopi, Soundhararajan, and Athi N. Naganathan. "Non-specific DNA-driven quinary interactions promote structural transitions in proteins." Physical Chemistry Chemical Physics 22, no. 22 (2020): 12671–77. http://dx.doi.org/10.1039/d0cp01758b.

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We show strong evidence for the long-range electrostatic potential of DNA to influence the conformational status and distribution of states accessible to a protein chain well before the binding event.

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13

Minnick, Michael F., Kate N. Sappington, Laura S. Smitherman, Siv G. E. Andersson, Olof Karlberg, and James A. Carroll. "Five-Member Gene Family of Bartonella quintana." Infection and Immunity 71, no. 2 (2003): 814–21. http://dx.doi.org/10.1128/iai.71.2.814-821.2003.

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ABSTRACT Bartonella quintana, the agent of trench fever and an etiologic agent of bacillary angiomatosis, has an extraordinarily high hemin requirement for growth compared to other bacterial pathogens. We previously identified the major hemin receptor of the pathogen as a 30-kDa surface protein, termed HbpA. This report describes four additional homologues that share approximately 48% amino acid sequence identity with hbpA. Three of the genes form a paralagous cluster, termed hbpCAB, whereas the other members, hbpD and hbpE, are unlinked. Secondary structure predictions and other evidence sugg

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14

Gargiulo, Laura, Montserrat Bermejo, and Antonio Liras. "Disminución de los niveles de óxido nítrico sintasa y proteína quinasa C neuronales en la enfermedad de Alzheimer." Revista de Neurología 30, no. 04 (2000): 301. http://dx.doi.org/10.33588/rn.3004.99196.

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15

Liang, Zhongxing, and Didier Raoult. "Differentiation of Bartonella Species by a Microimmunofluorescence Assay, Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis, and Western Immunoblotting." Clinical Diagnostic Laboratory Immunology 7, no. 4 (2000): 617–24. http://dx.doi.org/10.1128/cdli.7.4.617-624.2000.

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ABSTRACT Bartonella species can be differentiated by microimmunofluorescence assay, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and immunoblotting with murine polyclonal antisera to Bartonella henselae, B. quintana, B. elizabethae, and B. bacilliformis. A pairwise comparison on the basis of SDS-PAGE protein profiles demonstrated similarity values for proteins of different Bartonella species ranging from 28.6 to 86.4%. Antigenic relationships revealed by immunoblotting with murine antisera were equivalent to those of proteins observed by SDS-PAGE. A dendrogram obtained

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16

D’Argenio, David A., Ana Segura, Wayne M. Coco, Patricia V. Bünz, and L. Nicholas Ornston. "The Physiological Contribution ofAcinetobacter PcaK, a Transport System That Acts upon Protocatechuate, Can Be Masked by the Overlapping Specificity of VanK." Journal of Bacteriology 181, no. 11 (1999): 3505–15. http://dx.doi.org/10.1128/jb.181.11.3505-3515.1999.

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ABSTRACT VanK is the fourth member of the ubiquitous major facilitator superfamily of transport proteins to be identified that, together with PcaK, BenK, and MucK, contributes to aromatic catabolism inAcinetobacter sp. strain ADP1. VanK and PcaK have overlapping specificity for p-hydroxybenzoate and, most clearly, for protocatechuate: inactivation of both proteins severely impairs growth with protocatechuate, and the activity of either protein alone can mask the phenotype associated with inactivation of its homolog. Furthermore, vanK pcaK double-knockout mutants appear completely unable to gro

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17

Song, Xiangfei, Liaoyuan An, Mengting Wang, Jingfei Chen, Zhijun Liu, and Lishan Yao. "Osmolytes Can Destabilize Proteins in Cells by Modulating Electrostatics and Quinary Interactions." ACS Chemical Biology 16, no. 5 (2021): 864–71. http://dx.doi.org/10.1021/acschembio.1c00024.

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18

Mondadori, Rafael Gianella, Paulo Bayard Dias Gonçalves, Jairo Pereira Neves, et al. "Fecundação e clivagem após a ativação da proteína quinase C durante a maturação de oócitos bovinos." Ciência Rural 29, no. 1 (1999): 105–10. http://dx.doi.org/10.1590/s0103-84781999000100019.

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A formação de pró-núcleos, clivagem e perfil protéico foram avaliados após a ativação da proteína quinase C (PQ-C) durante a maturação de complexos cumulus-oócito (CCOs) bovinos. Visando a determinar estes efeitos da PQ-C, 1936 CCOs foram distribuídos aleatoriamente em 4 tratamentos, sendo maturados na presença de PMA (100nM phorbol 12-myristate 13-acetate, ativador da PQ-C), de 4alfa-PDD (100nM de 4alfa-phorbol 12,13-didecanoetate, forbol éster que não ativa a PQ-C; controle forbol éster), de SVE (10% de soro de vaca em estro, controle positivo) e de um controle negativo constituído pelo meio

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19

Gilmore, Robert D., Travis M. Bellville, Steven L. Sviat, and Michael Frace. "The Bartonella vinsonii subsp. arupensis Immunodominant Surface Antigen BrpA Gene, Encoding a 382-Kilodalton Protein Composed of Repetitive Sequences, Is a Member of a Multigene Family Conserved among Bartonella Species." Infection and Immunity 73, no. 5 (2005): 3128–36. http://dx.doi.org/10.1128/iai.73.5.3128-3136.2005.

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ABSTRACT Bartonella proteins that elicit an antibody response during an infection are poorly defined; therefore, to characterize antigens recognized by the host, a Bartonella genomic expression library was screened with serum from an infected mouse. This process led to the discovery of a Bartonella vinsonii subsp. arupensis gene encoding a 382-kDa protein, part of a gene family encoding large proteins, each containing multiple regions of repetitive segments. The genes were termed brpA to -C (bartonella repeat protein) and bore significant similarity to genes encoding the BadA adhesin protein a

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20

Lyonnais, Sébastien, S. Kashif Sadiq, Cristina Lorca-Oró, et al. "The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation." Viruses 13, no. 11 (2021): 2312. http://dx.doi.org/10.3390/v13112312.

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A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules. These phase-separated molecular ‘sponges’, stabilized by quinary (transient and weak) interactions, control proteins involved in numerous biological functions. Retroviruses such as HIV-1 form by self-assembly when their genomic RNA (gRNA) traps Gag and GagPol polyprotein precursors. Infectivity requires extracellular budding of the particle followed by maturation, an ordered processing of ∼2400 Gag and ∼120 GagPol by the viral protease (PR). Thi

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Patiño González, Edwin, Isabel Andrea Patiño Márquez, and Juan Fernando Alzate. "Cristalización y predicción de la estructura tridimensional de la proteína homóloga del receptor activado para la quinasa c (lack) de leishmania." Revista Colombiana de Química 43, no. 3 (2015): 17–23. http://dx.doi.org/10.15446/rev.colomb.quim.v43n3.53612.

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<p>Los parásitos del género Leishmania son<br />los causantes de la enfermedad conocida<br />como Leishmaniasis. Esta enfermedad es<br />endémica en 98 países. Veinte especies de<br />Leishmania sp han sido descritas como<br />patógenos en humanos y varias de ellas<br />presentan manifestaciones clínicas diferentes.<br />No se dispone de vacuna, a pesar del<br />considerable esfuerzo de muchos grupos de<br />investigación. Las alternativas para descubrir<br />nuevos medicamentos están basadas en el<br />diseño de compuesto

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Battisti, James M., Kate N. Sappington, Laura S. Smitherman, Nermi L. Parrow, and Michael F. Minnick. "Environmental Signals Generate a Differential and Coordinated Expression of the Heme Receptor Gene Family of Bartonella quintana." Infection and Immunity 74, no. 6 (2006): 3251–61. http://dx.doi.org/10.1128/iai.00245-06.

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ABSTRACT Of all bacteria, Bartonella quintana has the highest reported in vitro hemin requirement, yet an explanation for this remains elusive. To produce diseases such as trench fever, endocarditis, and bacillary angiomatosis, B. quintana must survive and replicate in the disparate environments of the Pediculus humanus corporis (body louse) gut and the human vasculature. We previously identified a five-member family of hemin binding proteins (Hbps) synthesized by B. quintana that bind hemin on the outer surface but share no similarity to known bacterial heme receptors. In the present study, w

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Matsuoka, Mayumi, Toshinori Sasaki, Naomi Seki, et al. "Hemin-Binding Proteins as Potent Markers for Serological Diagnosis of Infections with Bartonella quintana." Clinical and Vaccine Immunology 20, no. 4 (2013): 620–26. http://dx.doi.org/10.1128/cvi.00717-12.

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ABSTRACTIt is difficult to distinguish infections with differentBartonellaspecies using commercially available immunofluorescence (indirect immunofluorescent antibody [IFA]) assay kits. To identify appropriate proteins for serodiagnosis ofBartonella quintanainfections, we investigated the antigenicity ofB. quintanaproteins using sera from homeless people with highB. quintanaIgG titers in IFA assay. These sera reacted strongly to an outer membrane protein, hemin-binding protein D (HbpD). Further, serum from an endocarditis patient infected withB. quintanareacted to HbpB and HbpD. To locate the

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Kang, Xiangbo, H. Ekkehard Neuhaus, and Renate Scheibe. "Subcellular Localization of Quinate: Oxidoreductase from Phaseolus mungo L. Sprouts." Zeitschrift für Naturforschung C 49, no. 7-8 (1994): 415–20. http://dx.doi.org/10.1515/znc-1994-7-805.

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Quinate:oxidoreductase (QORase, EC 1.1.1.24) was isolated and purified from etiolated mung bean (Phaseolus mungo L.) sprouts and a monospecific antiserum was raised in rabbit to the homogeneous protein. Highly intact etioplasts were isolated from the same plant material. The stroma of the purified etioplasts was enzymatically characterized. Contamination by cytosol, mitochondria and vacuole was estimated from activities of marker enzymes. QORase activity was localized in the stroma (about 91% for both NAD+ and NADP+ as a cofactor). Western blotting and immunoprinting of the stroma proteins re

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25

Malagrinò, Francesca, Valeria Pennacchietti, Daniele Santorelli, et al. "On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains." Biomolecules 12, no. 2 (2022): 209. http://dx.doi.org/10.3390/biom12020209.

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The vast majority of our current knowledge about the biochemical and biophysical properties of proteins derives from in vitro studies conducted on isolated globular domains. However, a very large fraction of the proteins expressed in the eukaryotic cell are structurally more complex. In particular, the discovery that up to 40% of the eukaryotic proteins are intrinsically disordered, or possess intrinsically disordered regions, and are highly dynamic entities lacking a well-defined three-dimensional structure, revolutionized the structure–function paradigm and our understanding of proteins. Mor

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Kelly, Timothy M., Indira Padmalayam, and Barbara R. Baumstark. "Use of the Cell Division Protein FtsZ as a Means of Differentiating among Bartonella Species." Clinical Diagnostic Laboratory Immunology 5, no. 6 (1998): 766–72. http://dx.doi.org/10.1128/cdli.5.6.766-772.1998.

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ABSTRACT Genes coding for homologs of the highly conserved cell division protein FtsZ were isolated from Bartonella henselae andBartonella quintana, the causative agents of cat scratch disease and trench fever, respectively. DNA fragments coding for theftsZ open reading frames (ORFs) were cloned intoEscherichia coli following PCR amplification with primers based on the ftsZ sequence of the closely related speciesBartonella bacilliformis. The amino acid sequences predicted from the cloned B. henselae and B. quintana ftsZ ORFs are 81 to 83% identical to the corresponding protein in B. bacillifor

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27

Parrow, Nermi L., Jasmin Abbott, Amanda R. Lockwood, James M. Battisti, and Michael F. Minnick. "Function, Regulation, and Transcriptional Organization of the Hemin Utilization Locus of Bartonella quintana." Infection and Immunity 77, no. 1 (2008): 307–16. http://dx.doi.org/10.1128/iai.01194-08.

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ABSTRACT Bartonella quintana is a gram-negative agent of trench fever, chronic bacteremia, endocarditis, and bacillary angiomatosis in humans. B. quintana has the highest known hemin requirement among bacteria, but the mechanisms of hemin acquisition are poorly defined. Genomic analyses revealed a potential locus dedicated to hemin utilization (hut) encoding a putative hemin receptor, HutA; a TonB-like energy transducer; an ABC transport system comprised of three proteins, HutB, HutC, and HmuV; and a hemin degradation/storage enzyme, HemS. Complementation analyses with Escherichia coli hemA sh

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Tran, Nguyen H. N., Nadin Shagaghi, and Andrew H. A. Clayton. "Using fluorescence lifetime dequenching to estimate the average quinary stoichiometry of proteins in living cells." Methods and Applications in Fluorescence 8, no. 1 (2019): 014003. http://dx.doi.org/10.1088/2050-6120/ab4ebb.

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29

Müller, Niklas F., Patrick O. Kaiser, Dirk Linke, et al. "Trimeric Autotransporter Adhesin-Dependent Adherence of Bartonella henselae, Bartonella quintana, and Yersinia enterocolitica to Matrix Components and Endothelial Cells under Static and Dynamic Flow Conditions." Infection and Immunity 79, no. 7 (2011): 2544–53. http://dx.doi.org/10.1128/iai.01309-10.

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ABSTRACTTrimeric autotransporter adhesins (TAAs) are important virulence factors of Gram-negative bacteria responsible for adherence to extracellular matrix (ECM) and host cells. Here, we analyzed three different TAAs (Bartonellaadhesin A [BadA] ofBartonella henselae, variably expressed outer membrane proteins [Vomps] ofBartonella quintana, andYersiniaadhesin A [YadA] ofYersinia enterocolitica) for mediating bacterial adherence to ECM and endothelial cells. Using static (cell culture vials) and dynamic (capillary flow chambers) experimental settings, adherence of wild-type bacteria and of the

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McGill, Svena L., Russell L. Regnery, and Kevin L. Karem. "Characterization of Human Immunoglobulin (Ig) Isotype and IgG Subclass Response to Bartonella henselae Infection." Infection and Immunity 66, no. 12 (1998): 5915–20. http://dx.doi.org/10.1128/iai.66.12.5915-5920.1998.

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ABSTRACT Serologic parameters of cat scratch disease (CSD) were evaluated by Western blot analysis. Sera from patients with serologically confirmed CSD antigen were screened for immunoglobulin (Ig) isotype-specific as well as IgG subclass-specific reactivity against Bartonella henselae whole-cell antigen. Bartonella-negative control sera were used to determine baseline antibody activity. Heterogeneous B. henselae-specific IgG reactivity with numerous protein bands, ranging from >150 to <17 kDa, was observed. Though individual banding patterns were variable, one approximately 83-kDa B. he

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Hawkins, A. R., J. D. Moore, and A. M. Adeokun. "Characterization of the 3-dehydroquinase domain of the pentafunctional AROM protein, and the quinate dehydrogenase from Aspergillus nidulans, and the overproduction of the type II 3-dehydroquinase from neurospora crassa." Biochemical Journal 296, no. 2 (1993): 451–57. http://dx.doi.org/10.1042/bj2960451.

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The AROM protein of Aspergillus nidulans is a multidomain pentafunctional polypeptide that is active as a dimer and catalyses steps 2-6 in the prechorismate section of the shikimate pathway. The three C-terminal domains (including the type I 3-dehydroquinase) of the AROM protein are homologous with the qutR-encoded QUTR protein that represses transcription of the eight genes comprising the quinic acid utilization (qut) gene cluster, and the two N-terminal domains are homologous with the qutA-encoded QUTA protein that transcribes the qut genes. As part of a larger research programme designed to

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32

Cong, Qian, Jinhui Shen, Dominika Borek, et al. "When COI barcodes deceive: complete genomes reveal introgression in hairstreaks." Proceedings of the Royal Society B: Biological Sciences 284, no. 1848 (2017): 20161735. http://dx.doi.org/10.1098/rspb.2016.1735.

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Two species of hairstreak butterflies from the genus Calycopis are known in the United States: C. cecrops and C. isobeon . Analysis of mitochondrial COI barcodes of Calycopis revealed cecrops -like specimens from the eastern US with atypical barcodes that were 2.6% different from either USA species, but similar to Central American Calycopis species. To address the possibility that the specimens with atypical barcodes represent an undescribed cryptic species, we sequenced complete genomes of 27 Calycopis specimens of four species: C. cecrops , C. isobeon , C. quintana and C. bactra . Some of th

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Zhang, P., B. B. Chomel, M. K. Schau, et al. "A family of variably expressed outer-membrane proteins (Vomp) mediates adhesion and autoaggregation in Bartonella quintana." Proceedings of the National Academy of Sciences 101, no. 37 (2004): 13630–35. http://dx.doi.org/10.1073/pnas.0405284101.

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Bertagnolli, A. C., P. B. D. Gonçalves, I. C. Giometti, et al. "Interação entre células do cumulus e atividade da proteína quinase C em diferentes fases da maturação nuclear de oócitos bovinos." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 56, no. 4 (2004): 488–96. http://dx.doi.org/10.1590/s0102-09352004000400010.

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Verificou-se a influência da proteína quinase C (PK-C) no reinício e na progressão da meiose em oócitos bovinos, determinando se as células do cumulus são mediadoras da PK-C na regulação da maturação dos oócitos. Complexos cumulus-oócitos (CCO) e oócitos desnudos (OD), distribuídos aleatoriamente em seis tratamentos (T) com base na presença de um ativador da PK-C (PMA) (T1 e T2), de um forbol éster incapaz de ativar a PK-C (4alfa-PDD-controle) (T3 e T4) ou de apenas o meio básico (TCM-199-controle) (T5 e T6), foram cultivados por 7, 9, 12, 18 e 22 horas. A percentagem de rompimento da vesícula

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Tömösközi, S., L. Gyenge, A. Pelcéder, T. Abonyi, and R. Lásztity. "The effects of flour and protein preparations from amaranth and quinoa seeds on the rheological properties of wheat-flour dough and bread crumb." Czech Journal of Food Sciences 29, No. 2 (2011): 109–16. http://dx.doi.org/10.17221/45/2010-cjfs.

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The effects of amaranth and quinoa flours and protein isolates prepared from amaranth and quinoa seeds on the rheological properties of wheat flour dough and bread were studied using new recording instruments, the micro Z-arm mixer (for dough) and the SMS-Texture analyser (for bread crumb). The addition of 10% amaranth or quinoa flours did not cause significant changes in rheological properties. However, higher additions (20% and 30%) resulted in significant changes in stability, the degree of softening and elasticity. Substitution of wheat flour by amaranth or quinoa flours resulted in an inc

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Smith, Michael A., Valerie B. Weaver, David M. Young, and L. Nicholas Ornston. "Genes for Chlorogenate and Hydroxycinnamate Catabolism (hca) Are Linked to Functionally Related Genes in the dca-pca-qui-pob-hca Chromosomal Cluster of Acinetobacter sp. Strain ADP1." Applied and Environmental Microbiology 69, no. 1 (2003): 524–32. http://dx.doi.org/10.1128/aem.69.1.524-532.2003.

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ABSTRACT Hydroxycinnamates are ubiquitous in the environment because of their contributions to the structure and defense mechanisms of plants. Additional plant products, many of which are formed in response to stress, support the growth of Acinetobacter sp. strain ADP1 through pathways encoded by genes in the dca-pca-qui-pob chromosomal cluster. In an appropriate genetic background, it was possible to select for an Acinetobacter strain that had lost the ability to grow with caffeate, a commonly occurring hydroxycinnamate. The newly identified mutation was shown to be a deletion in a gene desig

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Pham Phuong, Thu, Ha Chu Duc, Thao Nguyen Song, and Huyen Tran Thi Thanh. "Classification and analysis of conserved motifs in the sucrose transporter family in quinoa (Chenopodium quinoa) by bioinformatics approach." Journal of Science Natural Science 66, no. 4F (2021): 188–95. http://dx.doi.org/10.18173/2354-1059.2021-0082.

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In this study, a total of 29 members of the CqSWEET family in quinoa (Chenopodium quinoa) has been comprehensively investigated by various bioinformatics methods. As the result, we indicated that the CqSWEET proteins were varied from 161 - 428 amino acid residues in size (17,7 - 47,7 kDa in weight). The isoelectric point of these proteins ranged from acid (4.9) to base (9,7), while the majority of the CqSWEET proteins are stable in the test tube. Our analyses also revealed that whole members of the CqSWEET family are hydrophobic, and a large amount of the CqSWEET proteins may localize in the s

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Lamb, H. K., G. H. Newton, L. J. Levett, E. Cairns, C. F. Roberts, and A. R. Hawkins. "The QUTA activator and QUTR repressor proteins of Aspergillus nidulans interact to regulate transcription of the quinate utilization pathway genes." Microbiology 142, no. 10 (1996): 2983. http://dx.doi.org/10.1099/13500872-142-10-2983.

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Lamb, H. K., G. H. Newton, L. J. Levett, E. Cairns, C. F. Roberts, and A. R. Hawkins. "The QUTA activator and QUTR repressor proteins of Aspergillus nidulans interact to regulate transcription of the quinate utilization pathway genes." Microbiology 142, no. 6 (1996): 1477–90. http://dx.doi.org/10.1099/13500872-142-6-1477.

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Roa Linares, Vicky Constanza, and Juan Carlos Gallego Gómez. "La pérdida de función de la quinasa dependiente de ciclina 5 (CDK5) altera el citoesqueleto y reduce la infección in vitro por el virus del dengue 2." Acta Biológica Colombiana 24, no. 3 (2019): 474–85. http://dx.doi.org/10.15446/abc.v24n3.79347.

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La quinasa dependiente de ciclina 5 (CDK5) regula diversas funciones en neuronas, células endoteliales y epiteliales, entre ellas la dinámica del citoesqueleto. Así mismo, se ha reportado que componentes del citoesqueleto, tales como, filamentos de actina y microtúbulos juegan un rol importante durante la infección por el virus dengue (DENV). El objetivo del presente trabajo fue evaluar por dos métodos, inhibición química y silenciamiento génico, la participación de CDK5 durante la infección por DENV-2. La actividad antiviral de roscovitina fue evaluada usando ensayos de Unidades Formadoras de

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Hsieh, Ricardo, Fabrício Bitu Sousa, Aline Firmiano, Fabio Daumas Nunes, Marina Helena Cury Gallottini de Magalhães, and Mírian Nacagami Sotto. "Estudo genético do gene p16 pela técnica de PCR-SSCP e expressão de proteína p16 em melanomas de mucosa oral e melanomas cutâneos." Anais Brasileiros de Dermatologia 81, no. 5 (2006): 433–41. http://dx.doi.org/10.1590/s0365-05962006000500005.

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FUNDAMENTOS: A deleção e mutação do gene CDKN2a que codifica um inibidor específico da ciclina dependente de quinase 4, a proteína p16, têm sido implicadas na tumorigênese do melanoma cutâneo. Entretanto, pouco se conhece sobre essas alterações genéticas em melanomas de mucosa oral. OBJETIVOS: Verificar a presença de alterações no gene p16 e sua expressão protéica em melanomas esporádicos orais e cutâneos. MATERIAL E MÉTODOS: Avaliaram-se 36 espécimes de melanoma primário (sete orais e 29 cutâneos). Analisaram-se três exons do gene p16, pela técnica da reação em cadeia da polimerase/polimorfis

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Battisti, James M., Laura S. Smitherman, Kate N. Sappington, Nermi L. Parrow, Rahul Raghavan, and Michael F. Minnick. "Transcriptional Regulation of the Heme Binding Protein Gene Family of Bartonella quintana Is Accomplished by a Novel Promoter Element and Iron Response Regulator." Infection and Immunity 75, no. 9 (2007): 4373–85. http://dx.doi.org/10.1128/iai.00497-07.

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ABSTRACT We previously identified a five-member family of hemin-binding proteins (Hbp's) of Bartonella quintana that bind hemin on the outer surface but share no homology with known bacterial heme receptors. Subsequently, we demonstrated that expression of the hbp family is significantly influenced by oxygen, heme, and temperature conditions encountered by the pathogen in the human host and the body louse vector; e.g., we observed a dramatic (>100-fold) increase in hbpC transcript levels in response to the “louse-like” temperature of 30°C. The goal of the present study was to identify a tra

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Ballester-Sánchez, Millán-Linares, Fernández-Espinar, and Haros. "Development of Healthy, Nutritious Bakery Products by Incorporation of Quinoa." Foods 8, no. 9 (2019): 379. http://dx.doi.org/10.3390/foods8090379.

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The use of quinoa could be a strategy for the nutritional improvement of bakery products. The inclusion of this pseudocereal, with its suitable balance of carbohydrates, proteins, lipids and minerals, could contribute to attaining the adequate intake values proposed by the FAO (Food and Agriculture Organization) and/or EFSA (European Food Safety Authority) for suitable maintenance and improvement of the population’s health. Bakery products made with white, red or black royal quinoa significantly improved the contribution to an adequate intake of polyunsaturated fatty acids (linoleic and linole

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Vega Joubert, Michelle, María Eugenia Oliva, Maria del Rosario Ferreira, and Maria Eugenia D'Alessandro. "Adiposidad visceral y resistencia insulínica: rol de la AMPK." FABICIB 23 (March 10, 2020): 29–44. http://dx.doi.org/10.14409/fabicib.v23i0.8367.

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Introducción: la disfunción del tejido adiposo constituye un punto central en el desarrollo de la resistencia insulínica y otras alteraciones asociadas al Síndrome Metabólico. La proteína quinasa activada por AMP (AMPK) es considerada un sensor metabólico celular, con un importante rol en la regulación de la actividad metabólica del tejido adiposo blanco. Objetivos: evaluar los efectos de la administración crónica de una dieta rica en sacarosa sobre algunos mecanismos involucrados en la disfunción del tejido adiposo y su relación con la resistencia insulínica. Materiales y métodos:

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Salhi, Imed, Rose-Anne Boigegrain, Jan Machold, Christoph Weise, Axel Cloeckaert, and Bruno Rouot. "Characterization of New Members of the Group 3 Outer Membrane Protein Family of Brucella spp." Infection and Immunity 71, no. 8 (2003): 4326–32. http://dx.doi.org/10.1128/iai.71.8.4326-4332.2003.

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ABSTRACT Impairment of the omp25 gene in Brucella spp. leads to attenuated strains and confers protection to the host. Omp25 and Omp31, whose functions remain unknown, were the first characterized members of group 3 outer membrane proteins (Omps) (25 to 34 kDa). Recently, genomic and proteomic approaches identified five new putative members of this family, some of which are produced in B. melitensis or B. abortus. In the present study, using protein microsequencing, we identified new members of group 3 Omps proteins produced in B. suis. Since several monoclonal antibodies (MAbs) against Omp25

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Marsh, Ken B., Helen L. Boldingh, Rebecca S. Shilton, and William A. Laing. "Changes in quinic acid metabolism during fruit development in three kiwifruit species." Functional Plant Biology 36, no. 5 (2009): 463. http://dx.doi.org/10.1071/fp08240.

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Kiwifruit are novel in that they contain high levels of quinic acid (1–2% w/w), which contributes to the flavour, sugar/acid balance and health-giving properties of the fruit. In a study of quinic acid storage and metabolism in three kiwifruit species (Actinidia chinensis Planch. var. chinensis, Actinidia deliciosa (A. Chev.) C.F. Liang et A.R. Ferguson var. deliciosa and Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq. var. arguta) quinic acid accumulation occurred principally in the early stages (<60 days after anthesis; (DAA)) of fruit development. The present study established that the

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Chenoweth, Matthew R., Craig E. Greene, Duncan C. Krause, and Frank C. Gherardini. "Predominant Outer Membrane Antigens of Bartonella henselae." Infection and Immunity 72, no. 6 (2004): 3097–105. http://dx.doi.org/10.1128/iai.72.6.3097-3105.2004.

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ABSTRACT A hallmark of Bartonella henselae is persistent bacteremia in cats despite the presence of a vigorous host immune response. To understand better the long-term survival of B. henselae in cats, we examined the feline humoral immune response to B. henselae outer membrane (OM) proteins in naturally and experimentally infected cats. Initially, a panel of sera (n = 42) collected throughout North America from naturally infected cats was used to probe B. henselae total membranes to detect commonly recognized antigens. Twelve antigens reacted with sera from at least 85% of cats, and five were

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Selenko, Philipp. "Quo Vadis Biomolecular NMR Spectroscopy?" International Journal of Molecular Sciences 20, no. 6 (2019): 1278. http://dx.doi.org/10.3390/ijms20061278.

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In-cell nuclear magnetic resonance (NMR) spectroscopy offers the possibility to study proteins and other biomolecules at atomic resolution directly in cells. As such, it provides compelling means to complement existing tools in cellular structural biology. Given the dominance of electron microscopy (EM)-based methods in current structure determination routines, I share my personal view about the role of biomolecular NMR spectroscopy in the aftermath of the revolution in resolution. Specifically, I focus on spin-off applications that in-cell NMR has helped to develop and how they may provide br

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Lozano-Picazo, Carmen María, and Francisco Fernández-Belda. "Especies reactivas de oxígeno y su implicación en Biomedicina." Anales de Veterinaria de Murcia 34 (December 16, 2020): 17–26. http://dx.doi.org/10.6018/analesvet.332621.

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Las especies reactivas de oxígeno (ROS) actúan como regulador intracelular cuando se generan de forma controlada en puntos concretos de la célula. Modifican la función de proteínas mediante la oxidación reversible de cisteínas. Hay quinasas y fosfatasas de proteínas, factores de transcripción y canales iónicos que están regulados por ROS. Estrés oxidativo y daño celular aparecen cuando los mecanismos antioxidantes de protección son incapaces de mantener bajo el nivel intracelular de ROS. En estas condiciones, ROS inducen pérdida de viabilidad celular en patologías degenerativas de corazón y ce

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Mahmod Al-Qattan, Mohammed Nooraldeen, and Mohd Nizam Mordi. "Molecular Basis of Modulating Adenosine Receptors Activities." Current Pharmaceutical Design 25, no. 7 (2019): 817–31. http://dx.doi.org/10.2174/1381612825666190304122624.

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Modulating cellular processes through extracellular chemical stimuli is medicinally an attractive approach to control disease conditions. GPCRs are the most important group of transmembranal receptors that produce different patterns of activations using intracellular mediators (such as G-proteins and Beta-arrestins). Adenosine receptors (ARs) belong to GPCR class and are divided into A1AR, A2AAR, A2BAR and A3AR. ARs control different physiological activities thus considered valuable target to control neural, heart, inflammatory and other metabolic disorders. Targeting ARs using small molecules

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