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Dissertations / Theses on the topic 'Proteine antigelo'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

MANGIAGALLI, MARCO. "Structural and functional analyses of an ice-binding protein from an Antarctic bacterium." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241269.

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Una proteina in grado di legare i cristalli di ghiaccio è definita proteina legante il ghiaccio o IBP acronimo dall’inglese ice-binding protein. Le IBP grazie alla loro capacità di abbassare il punto di congelamento dell’acqua, aumentando il gap di isteresi termica (TH). Questo intervallo è definito come la differenza tra il punto di fusione e di congelamento dell’acqua. La seconda attività delle IBP è l’inibizione della ricristallizzazione del ghiaccio (ice recrystallization inhibition, IRI). Infatti, queste proteine stabilizzano i piccoli cristalli di ghiaccio impedendo la formazione di cris

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2

Varelias, Antiopi. "Studies of CD44 variant isoform expression and function on activated human peripheral blood mononuclear cells and in renal transplantation." Title page, summary and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phv293.pdf.

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3

Winchester, Christopher Charles. "The roles of Hsp70 proteins in antigen processing and presentation." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:567dff45-08ce-43b4-b011-d08afea42f76.

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The ability of members of the hsp70 family to bind to peptides in vivo and in vitro suggests that they may be involved in the processing of antigens for binding to Major Histocompatibility (MHC) class I and/or class n molecules. The aims of this thesis have been to provide evidence for the involvement of hsp70s in antigen processing and to characterise the binding of peptides by hspTOs by structural and functional studies. Firstly, the peptide-binding domains of two hsp70s, hsp70hom and PBP74, were expressed in isolation from the rest of the molecule for structure determination. Both of these

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4

Malhotra, Shikha. "B-cell-antigen receptor endocytosis uses a distinct signaling pathway, involving LAB, Vav, dynamin and Grb2." Oklahoma City : [s.n.], 2009.

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5

MENTO, ALFREDO. "Unconventional purification and labelling strategies of bioreagents for immunodiagnostic assays." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/309986.

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Gli antigeni e gli anticorpi sono reagenti chiave per lo sviluppo di test immunodiagnostici accurati, riproducibili e sensibili, ampiamente utilizzati per la rilevazione di malattie infettive (HIV, HBV, HCV, ecc.) e per la determinazione di marcatori biologici (vitamine, ormoni, ecc.). Questi bioreagenti devono essere prodotti con un alto grado di purezza, in formulazioni stabili e con sufficiente riproducibilità nel tempo (consistenza da lotto a lotto). Un aspetto spesso trascurato nella produzione di questi reagenti è il loro costo, che deve essere sufficientemente basso da non avere un impa

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6

Lot, Perrine. "Les protéines antigel." Paris 5, 1988. http://www.theses.fr/1988PA05P219.

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7

Schumacher, Dominik. "Site-specific functionalization of antigen binding proteins for cellular delivery, imaging and target modulation." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18547.

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Antikörper und Antigen-bindende Proteine, die an Fluorophore, Tracer und Wirkstoffe konjugiert sind, sind einzigartige Moleküle, welche die Entwicklung wertvoller diagnostischer und therapeutischer Werkzeuge ermöglichen. Allerdings ist der Konjugationsschritt sehr anspruchsvoll und trotz intensiver Forschung noch immer ein bedeutender Engpass. Zusätzlich sind Antigen-bindende Proteine oftmals nicht dazu in der Lage, die Zellmembran zu durchdringen und im Zellinneren nicht funktionsfähig. Daher ist ihre Verwendung auf extrazelluläre Targets beschränkt, was eine bedeutende Anzahl wichtiger Antig

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8

Heinrich, Garrett. "A role for CEACAM proteins in energy balance and peripheral insulin action." Toledo, Ohio : University of Toledo, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1272976279.

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Dissertation (Ph.D.)--University of Toledo, 2010.<br>"Submitted to the Graduate Faculty as partial fulfillment of the requirements for the Doctor of Philosophy Degree in Biomedical Sciences." Title from title page of PDF document. "A Dissertation entitled"--at head of file. Bibliography: p. 37-41, 77-82, 102-107, 124-125, 153-160, 195-199, 221-254.

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9

Eynon, Elizabeth E. "Small B Cells as Antigen Presenting Cells in the Induction of Tolerance to Soluble Protein Antigens: A Dissertation." eScholarship@UMMS, 1991. https://escholarship.umassmed.edu/gsbs_diss/185.

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This thesis proposes a mechanism for the induction of peripheral tolerance to protein antigens. I have investigated the mechanism of tolerance induction to soluble protein antigens by targeting an antigen to small, resting B cells. For this purpose I have used a rabbit antibody directed at the IgD molecule found on the surface of most small, resting B cells but missing or lowered on activated B cells. Intravenous injection of normal mice with 100 μg of an ultracentrifuged Fab fragment of rabbit anti-mouse IgD (Fab anti-δ) makes these mice profoundly tolerant to challenge with nonimmune rabbit

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10

Scott, Carol Elizabeth DeWeese. "Molecular modeling and experimental characterization of HLA-DQ proteins and protein/peptide complexes : correlation with insulin-dependent diabetes mellitus (IDDM) /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8089.

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11

Cho, Uhn-Soo. "Structural studies of protein phosphatase 2A, simian virus 40 small t antigen, and the PhoQ sensor domain /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5677.

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12

Spadafina, Tiziana. "Characterization of Neisseria meningitidis GNA2132 antigen, a heparin binding protein cleaved by meningococcal NalP protease." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3427201.

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ABSTRACT GNA2132 (Genome-derived Neisseria Antigen 2132), a protein discovered by Reverse Vaccinology, is a surface-exposed lipoprotein expressed by genetically diverse Neisseria meningitidis strains. The protein induces bactericidal antibodies against most strains of meningococccus and has been included in a multivalent recombinant vaccine against N. meningitidis serogroup B. Sequence analysis of GNA2132 revealed the presence of an Arginine-rich region highly conserved among different strains. In this study we described that in meningococcus the protein is cleaved upstream from the Argin

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13

Michaëlsson, Jakob. "Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-286-8.

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14

Anderton, Stephen M. "A study of murine T lymphocyte responses to Streptococcus pyogenes." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287332.

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15

Forsman, Alma. "The Epstein-Barr virus nuclear antigens 1 & 5 : study of virus-host cellular protein interactions /." Göteborg : Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, 2009. http://hdl.handle.net/2077/21357.

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16

Lilyestrom, Wayne. "The structure of the complex containing the oncoprotein SV40 large tumour antigen bound to the p53 tumor suppressor /." Connect to full text via ProQuest. IP filtered, 2006.

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Thesis (Ph.D. in Biochemistry) -- University of Colorado, 2006.<br>Typescript. Includes bibliographical references (leaves 69-83). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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17

Clarke, Christopher John. "Antigen presentation to mucosal surfaces : the influence of liposome entrapment and cholera toxin on the immune response to fed protein antigens." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330040.

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18

Ramsay, Lesley Anne. "Humoral responses to acetaldehyde-modified protein antigens." Thesis, Anglia Ruskin University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286770.

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19

Frenger, Quentin. "Roles of autophagy-related proteins in antigen presentation by antigen presenting cells." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ043.

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La présentation antigénique joue un rôle crucial dans l'immunité adaptative. Les protéines d'autophagie orchestrent la macroautophagie, un processus essentiel pour l'homéostasie cellulaire, et peuvent également être recrutées sur des membranes endolysosomales. Ces processus influencent la présentation antigénique. J'ai démontré que la macroautophagie n'est pas dérégulée dans les cellules mononuclées du sang périphérique des patients atteints de sclérodermie systémique. Cependant, les macrophages ne recrutent pas efficacement LC3 sur les phagosomes. Les lymphocytes B capturent l'antigène via le

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20

Seabrook, Richard N. "An immunochemical study of B. pertussis antigens." Thesis, Queen Mary, University of London, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279600.

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21

Nguyen, Teresa. "Application of a Whole Genome Approach to the High Throughput Discovery of Novel Diagnostic Antigens for Brucella abortus." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40715.

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Brucella abortus is the etiological agent of bovine brucellosis, a zoonotic disease that can be transmitted to humans through direct contact with infected animals or consumption of contaminated food products. Current serological tests used to identify infected animals rely on the detection of antibodies to O-antigens of the smooth lipopolysaccharide (sLPS) of B. abortus. Due to the presence of structurally similar O-antigens of bacteria such as E. coli O:157 and Yersinia enterocolitica O:9, these tests can produce false-positive results, which requiring alternative protein target antigens. We

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22

Pickering, Maureen Gabrielle. "Immune responses to ingested protein antigens in mice." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/19235.

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23

Boulton-Jones, John Robert. "Oral tolerance to soluble protein antigens in humans." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/22766.

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In this thesis, a protocol to demonstrate oral tolerance is described. Keyhole limpet haemocyanin (KLH), a neo-antigen, was used to demonstrate low dose tolerance. A control group was immunised with KLH and the subsequent immune response was assessed by delayed type hypersensitivity responses, <i>in vitro</i> lymphocyte proliferation to KLH and anti-KLH IgG and IgA production. Another group of volunteers was pre-fed a course of KLH prior to receiving the same immunisation schedule. The same measures of the immune response used in the control group were assessed and any differences were attribu

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24

LOMBARDI, BENEDETTA. "Staphylococcal antigens characterization through a protein interaction approach." Doctoral thesis, Università del Piemonte Orientale, 2014. http://hdl.handle.net/11579/46757.

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25

NILO, ALBERTO. "Exploring carbohydrates antigens conjugated to pathogenrelated protein carriers." Doctoral thesis, Università del Piemonte Orientale, 2015. http://hdl.handle.net/11579/115558.

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26

Hauser, Thomas. "Definition immunogener Antigene bei der Akuten Myeloischen Leukämie mittels Serologischem Screening von cDNA-Expressionsbanken." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-56608.

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27

Peel, Mary. "A study of the protein antigens of Listeria monocytogenes." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/29939.

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28

Kerblat, Isabelle. "Étude de l'oxydoréduction dans l'apprêtement de l'antigène : implication de la thiorédoxine." Grenoble 1, 1997. http://www.theses.fr/1997GRE10054.

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Dans une cellule presentatrice, l'appretement de proteines exogenes comportant des ponts disulfures comprend une etape de reduction. L'oxydoreductase thioredoxine catalyse la reduction de substrats non specifiques. Son action sur la reduction et la proteolyse d'une imunoglobine g murine est significative dans la fraction lysosomale de cellules presentatrices. La thioredoxine active egalement les proteases a cysteine. Elle peut agir simultanement sur ces substrats, antigene disulfure et protease a cysteine, menant a la fragmentation de l'immunoglobuline g.

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29

Weiss, Timo. "Funktionelle Charakterisierung des granulozytären Antigens NB1 (CD177)." Giessen : VVB Laufersweiler, 2008. http://d-nb.info/991426673/04.

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30

Leishman, Andrew James. "Intervention in established immune responses by feeding protein antigens." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301603.

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31

Willhite, David Grant. "Purification, identification, and partial characterization of proteins associated with the adaptive immune response to soluble protein antigen in the American cockroach." Cincinnati, Ohio : University of Cincinnati, 2001. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1005252852.

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32

ALVES, JANAINA B. "Aspectos da resposta imune frente a antigenos proteicos irradiados com sup(60)Co." reponame:Repositório Institucional do IPEN, 2004. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11183.

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Made available in DSpace on 2014-10-09T12:49:16Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:01:33Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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33

Wang, Yibing. "Study of cysteines in the stalk region of CD3 proteins : evolutionarily conserved residues critical for T cell development and function /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 138-153). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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34

Willis, Dean. "The role of heat shock proteins in models of acute inflammation." Thesis, Queen Mary, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265943.

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35

Gall, Jason G. D. "The role of adenovirus fiber and hexon proteins in virus-host interactions /." Access full-text from WCMC:, 1998. http://proquest.umi.com/pqdweb?did=1432807591&sid=9&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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36

Nassar, M. I. A. "Immunohistochemical studies of clotting factors in renal disease." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383291.

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37

Gannon, Julian Vaughan. "Interactions between SV40 large T antigen and host proteins." Thesis, Institute of Cancer Research (University Of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314829.

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38

Herberg, Jethro Adam. "Antigen presenting genes and proteins of the human MHC." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298847.

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39

Gangloff, Sophie. "Les adhesines des bacteries du groupe mutans : cartographie antigenique d'une proteine de surface de streptococcus mutans." Strasbourg 1, 1991. http://www.theses.fr/1991STR15070.

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40

Maloy, Kevin Joseph. "The basis of the oral and parenteral adjuvant properties of immune stimulating complexes (ISCOMS)." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321045.

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41

Grazette, Affif. "Molecular characterisation of squamous cell carcinoma antigen recognised by T-cells 3, an adaptor protein of ubiquitin specific protease 15." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33081/.

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The deubiquitinating enzyme USP15, a member of the USP family, reverses the process of ubiquitination thereby altering the fate of a plethora of substrates. As such, USP15 has been implicated in a numerous important cellular pathways including cell cycle progression, transcriptional modification and DNA damage repair. The spliceosomal subunit recycling protein SART3 has been shown to bind to USP15 enhancing its deubiquitination of histone H2B thereby providing histone dimers for reassembly during subsequent rounds of transcription and splicing. Furthermore SART3 has also been shown to bind to

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42

Jarmin, Sarah Jane. "Investigation of protein tyrosine phosphatases in antigen receptor signalling." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619653.

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43

Guo, Beichu. "Interaction of PKCbeta with CARMA1 mediates B cell receptor-induced NF-kappaB activation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8348.

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44

Sundberg, Mårten. "Protein microarrays for validation of affinity binders." Licentiate thesis, KTH, Proteomik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-48256.

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Is specificity an important issue regarding affinity reagents? What about the validation of affinity reagents today, is it good enough? This depends on the application and the producer of the reagent. Validation should be the most important marketing argument that can be found.Today there is a continuous growth of both the number of affinity reagents that are produced and the different types of affinity reagents that are developed. In proteomics they become more and more important in exploring the human proteome. Therefore, validated affinity reagents should be on top of every proteomic resear

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45

AZZOUZ, NAHID. "Etude d'une glycosyl-phosphatidylinositol proteine : antigene de surface 156g de paramecium primaurelia." Paris 6, 1991. http://www.theses.fr/1991PA066402.

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Le protozoaire, paramecium aurelia, possede un repertoire d'antigenes de surface dont l'expression, mutuellement exclusive, est sous la dependance de parametres externes. Il s'agit d'isoproteines de hauts poids moleculaire, environ 300 kd, riches en threonine, serine et cysteine, sans fonction thiol libre. Il a ete etabli par une approche indirecte que ces proteines sont ancrees dans la membrane plasmique par un glycosyl phosphatidyl-inositol (gpi) et qu'il existait une phospholipase c endogene (pi-plc) capable de solubiliser ces molecules par clivage du diacylglycerol. Notre travail a porte s

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46

Chan, S. W. "Characterisation of a novel heat shock protein-enriched multivalent Streptococcus pneumoniae protein antigen vaccine." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1524189/.

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Current vaccination against Streptococcus pneumoniae uses vaccines based on capsular polysaccharides from a limited number of serotypes, which has led to replacement by non-vaccine serotypes. An alternative approach based on multiple protein antigens enriched with and bound to highly conserved heat-shock proteins (Hsps) could provide multivalent protection, thereby preventing the problem of serotype replacement. The work in this thesis using proteomic techniques shows that the Hsp vaccine preparation resulted in a product that was enriched with Hsps and contained several known important antige

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47

Kohli, Évelyne. "Etude des sites antigeniques de la proteine majeure de capside interne du rotavirus et application au diagnostic." Dijon, 1990. http://www.theses.fr/1990DIJO0001.

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48

Yan, Wei Xing. "Target antigen in chronic inflammatory demyelinating polyradiculoneuropathy." Thesis, The University of Sydney, 2001. https://hdl.handle.net/2123/27718.

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The primary purposes of this study were to investigate humoral factors in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), to determine pathogenicity of the factors found, and to detect possible target antigens in CIDP. Sera from 22 CIDP patients of whom 12 responded to plasma exchange therapy and 10 needed other therapy, were tested by means of enzyme-linked immunosorbent assay, immunofluorescence and Western blot techniques. Anti-whole myelin, anti-myelin glycoproteins (e.g. P0, P2, PMP22 and myelin associated glycoprotein), anti-myelin glycolipids (e.g. GMl, GM2, Gl

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49

BOULANGER, FLORENCE. "Toxoplasma gondii : identification, localisation et quantification de quatre antigenes immunodominants : conformation moleculaire et relation structure-activite de l'antigene majeur p30." Reims, 1991. http://www.theses.fr/1991REIMM204.

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50

Carson, Richard Thomas. "Immunoglobulin G subclass responses to bacterial protein antigens in man." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384823.

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