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Dissertations / Theses on the topic 'Proteine p126'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Conseil, Valérie. "Etude des proteolyses en culture et in vitro de la proteine p126 de plasmodium falciparum." Lille 2, 1996. http://www.theses.fr/1996LIL2T007.

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2

Gilardeau, Truffinet Myriam. "Etude de l'influence de modifications chimiques non ambigues et de differents adjuvants sur l'immunogenicite du peptide nt47 de la proteine p126 de plasmodium falciparum." Lille 2, 1996. http://www.theses.fr/1996LIL2T006.

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3

Erhorn, Frauke. "Die Funktion von Juv-p120 im Verlauf der Infektion mit Litomosoides sigmodontis." Giessen : VVB Laufersweiler, 2008. http://d-nb.info/988285762/04.

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4

Tang, Kit Shing. "Stability, folding and evolution of the tumour suppressor protein p16." Thesis, University of Cambridge, 2001. https://www.repository.cam.ac.uk/handle/1810/251785.

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5

Bauer, Marcus [Verfasser]. "Expression des p16 Proteins in humanen Tumoren und Normalgeweben / Marcus Bauer." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1236694937/34.

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6

Thullberg, Minna. "The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4432-6/.

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7

Mutalik, Vimi Sunil. "Comparative Assessment of p16 Protein Expression in Normal and Dysplastic Oral Mucosal Epithelium." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1530615395569555.

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8

Li, Junan. "Structural and functional studies on Tumor Suppressor INK4 Proteins P16(INK4A) and P18(INK4C) /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488194825665461.

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9

Junqueira, Mara de Souza. "Caracterização das vias de transformação maligna de uma nova linhagem estabelecida de melanoma murino." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-20092010-183837/.

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Ao longo dos processos de imortalização e transformação maligna, as células adquirem inúmeras alterações genéticas, que são causadas por fatores endógenos e exógenos como agentes biológicos e a geração de espécies reativas de oxigênio. Neste trabalho, uma linhagem celular espontaneamente transformada foi clonada a partir de explantes de embriões de camundongos C57bl/6. Esta linhagem mostrou-se produtora de pigmento escuro; a análise citoquímica e ultraestrutural permitiu caracterizar a linhagem como tendo origem melanocítica. A linhagem, denominada Mgal3, mostrou-se tumorigênica quando implant

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10

Wight, D. J. "Investigations into the function of the gammaretroviral protein p12 during the early stages of infection." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1410320/.

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The retroviral structural proteins (encoded by gag) are not merely the architecture of the virus but carry out a diverse set of functions throughout the viral life cycle. Initially translated as a polyprotein, the Gag protein functions to encapsidate the genome and assemble retroviral particles at the budding sites. This polyprotein is then cleaved into the mature proteins: matrix (MA), capsid (CA) and nucleocapsid (NC) upon viral release. Most retroviruses also contain a small protein between MA and CA of unknown function. In Moloney murine leukaemia virus (Mo-MLV) this protein is p12. p12 co

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11

Ojaniemi, M. (Marja). "Docking proteins p130^Cas and p120^Cbl in integrin and growth factor receptor signalling." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514253078.

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Abstract Adhesive interactions between cells and extracellular matrix proteins play a vital role in biological processes such as cell proliferation, differentiation and survival. Integrins comprise a major family of cell surface receptors that mediate these interactions. Integrin engagement triggers adhesion-dependent intracellular signalling cascades that include the phosphorylation of tyrosines in intracellular signalling proteins. Integrin-dependent signals act in concert with signals from growth factors and other signalling receptors. The objective of this thesis was to study how c

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12

Cheutin, Thierry. "Etude de l'organisation tridimensionnelle du nucleole par tomographie electronique (fascicule) (doctorat : genie biologique et medical)." Reims, 2000. http://www.theses.fr/2000REIMM211.

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13

Macpherson, Iain Roderick James. "A study of p120-catenin and its tyrosine phosphorylation in cancer cell adhesion and invasion." Thesis, Connect to e-thesis, 2007. http://theses.gla.ac.uk/1008/.

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Jesus, Jaqueline Goes. "Estudo da participação das proteínas Paxilina e Miosina-Va na infectividade do Vírus Linfotrópico de Células T Humanas do Tipo 1 (HTLV-1)." reponame:Repositório Institucional da FIOCRUZ, 2014. https://www.arca.fiocruz.br/handle/icict/12725.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2016-02-15T14:17:14Z No. of bitstreams: 1 Jaqueline Goes de Jesus. Estudo...2014.pdf: 4655999 bytes, checksum: 99ee2ef801cc69dd80d0a344e8f01be2 (MD5)<br>Approved for entry into archive by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2016-02-15T14:18:33Z (GMT) No. of bitstreams: 1 Jaqueline Goes de Jesus. Estudo...2014.pdf: 4655999 bytes, checksum: 99ee2ef801cc69dd80d0a344e8f01be2 (MD5)<br>Made available in DSpace on 2016-02-15T14:18:33Z (GMT). No. of bitstreams: 1 Jaqueline Goes de Jesus. Estudo...2014.pdf: 465

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Koehler, Jacqueline Anne. "Regulation of the GTPase-activating protein, p120[superscript]G[superscript)A[superscript]P, through its PH and CaLB domains." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ63721.pdf.

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16

Nitta, Ryan Takeo. "A-type lamins are necessary for the stabilization of the retinoblastoma protein /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9209.

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17

Nandadasa, Sumeda A. "Cadherin mediated F-actin assembly and the regulation of morphogenetic movements during Xenopus laevis development." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1276953030.

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18

Camilo, Henrique Passarelli. "Análise da expressão das proteínas celulares p53, p16 e ciclina D1 em amostras de tumores penianos /." São José do Rio Preto, 2014. http://hdl.handle.net/11449/111011.

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Orientador: Paula Rahal<br>Coorientador: Mânlio Tasso de Oliveira Mota<br>Banca: Carolina Colombelli Pacca<br>Banca: Silvana Gisele Pegorin de Campos<br>Resumo: O carcinoma epidermóide de pênis (CEP) é um tumor epitelial invasivo relativamente raro com alta morbidade, decorrente da própria doença ou de seu tratamento. Pacientes sem tratamento geralmente vão a óbito dentro de dois anos após o diagnóstico, devido o descontrole loco-regional ou a metástases distantes. Nos últimos anos, tem sido constatado que a infecção pelo vírus do papiloma humano (HPV), de alto risco, é um dos principais fator

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19

Sandmann, Vanessa [Verfasser]. "Untersuchung des Zusammenhanges von Malignomen der Glandula parotis, Humanen Papillomviren und der Überexpression des Proteins p16 ink4a / Vanessa Sandmann." Köln : Deutsche Zentralbibliothek für Medizin, 2018. http://d-nb.info/1170170099/34.

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Camilo, Henrique Passarelli [UNESP]. "Análise da expressão das proteínas celulares p53, p16 e ciclina D1 em amostras de tumores penianos." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/111011.

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Made available in DSpace on 2014-12-02T11:16:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-04-15Bitstream added on 2014-12-02T11:21:24Z : No. of bitstreams: 1 000796075.pdf: 1459054 bytes, checksum: 3ebaa1c352570cfcac9e744f29da4078 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O carcinoma epidermóide de pênis (CEP) é um tumor epitelial invasivo relativamente raro com alta morbidade, decorrente da própria doença ou de seu tratamento. Pacientes sem tratamento geralmente vão a óbito de

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21

Rodríguez, Chong Carlos [Verfasser]. "Untersuchungen von Antikörpern gegen Protein p16 (Matrixprotein) bei verschiedenen natürlich infizierten Spezies mit Bornaviruskrankheit / vorgelegt von Carlos Rodriguez Chong." Berlin : Mensch-und-Buch-Verl, 2010. http://d-nb.info/1012643034/34.

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22

Burbidge, Owen David. "Developing nanobodies to stabilise the tumour suppressor protein p16INK4a." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288375.

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The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. Dysregulation of the protein through deletion, silencing or mutation of the gene encoding p16 is implicated in a range of different cancers including melanoma, cervical and oesophageal to name a few. p16 is composed of four ankyrin repeats and it has a very low thermodynamic and kinetic stability and rapidly unfolds even in the absence of denaturants. This low stability m

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23

Koehler, Jacqueline Anne. "Understanding the function of the PH and CaLB domains of p120[superscript]G[superscript]A[superscript]P through the identification of interacting proteins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/MQ28783.pdf.

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24

Pakenham, Catherine. "Regulation of Neural Precursor Self-renewal via E2F3-dependent Transcriptional Control of EZH2." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23812.

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Our lab has recently found that E2F3, an essential cell cycle regulator, regulates the self-renewal capacity of neural precursor cells (NPCs) in the developing mouse brain. Chromatin immunoprecipitation (ChIP) and immunoblotting techniques revealed several E2F3 target genes, including the polycomb group (PcG) protein, EZH2. Further ChIP and immunoblotting techniques identified the neural stem cell self-renewal regulators p16INK4a and Sox2 as shared gene targets of E2F3 and PcG proteins, indicating that E2F3 and PcG proteins may co-regulate these target genes. E2f3-/- NPCs demonstrated dysre

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25

Hsieh, Ricardo. "Expressão da proteína p16, ciclina D1, CDK4 e proteína do retinoblastoma no melanoma acral lentiginoso." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-04112008-162931/.

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INTRODUÇÃO: O melanoma acral lentiginoso (MAL) tem freqüência expressiva entre os casos de melanoma observados no nosso meio e difere dos outros tipos clinicopatológicos de melanoma cutâneos por não ter a exposição solar como fator predisponente. Poucos trabalhos da literatura enfocam as alterações dos genes supressores de tumores e a expressão de suas proteínas nas lesões de MAL. Por esses motivos propusemo-nos a realizar um estudo retrospectivo visando uma melhor compreensão das proteínas envolvidas na via p16 INK4a /ciclina D1/CDK4/pRb do ciclo celular, no MAL em casuística brasileira. MÉTO

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26

Hashemi, Jamileh. "Germline CDKN2A/ARF alterations in human melanoma /." Stockholm : Karolinska institutet, 2002. http://diss.kib.ki.se/2002/91-7349-148-9.

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27

Lima, Marcos Antonio Pereira de. "Carcinoma de cÃlulas escamosas oral: relevÃncia do Papiloma vÃrus humano (HPV) e do vÃrus Epstein-Barr (EBV) na expressÃo de proteinas p16INK4a, E-caderina, COX-2, MLH1, p53 e MYC." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9728.

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FundaÃÃo de Amparo Ã Pesquisa do Estado do CearÃ<br>O cÃncer oral representa um sÃrio problema de saÃde pÃblica mundial. Entre os tumores deste sÃtio anatÃmico, os carcinomas de cÃlulas escamosas orais (CCEO) respondem por atÃ 94% do total. Os mecanismos moleculares envolvidos na gÃnese e desenvolvimento tumoral ainda nÃo estÃo completamente elucidados. Algumas evidÃncias tÃm sugerido a participaÃÃo viral neste processo. AlÃm disso, estes tumores ainda carecem de marcadores confiÃveis para determinar o perfil de agressividade. Neste contexto, o presente estudo teve como objetivo avaliar a expr

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28

A, Jamal A. Rahman Bin. "Analysis of gene rearrangement and protein expression of the tumour suppressor genes RB and P16 in patients with acute myeloid leukaemia : possible roles in leukaemogenesis leukaemia." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362773.

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29

Amjad, Arshi. "Analysis of cellular retinoic acid binding protein 2 expression in dermal fibroblasts; role in non-healing of chronic wounds." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59103.

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Abstract Chronic, non-healing wounds constitute a massive financial burden on health care system. The healing processes of these wounds and their underlying pathology are only partly understood. In this study, important biological functions performed by Retinoic acid with its regulatory protein cellular retinoic acid binding protein 2 (CRABP2) were discussed. Possibly, these biological func-tions might be linked with chronic wound therapeutic by inducing antiproliferative activity of cells which leads to reduction in migration and growth rate of fibroblast during skin regeneration pro-cess in

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30

Bellini, Marilanda Ferreira [UNESP]. "Estudos imuno-histoquímico das proteínas p53, p16, Fhit, caspase 3 e antígeno Ki67 ; e citogenético molecular em lesões benignas e carcinoma de esôfago." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/102727.

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Made available in DSpace on 2014-06-11T19:32:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-20Bitstream added on 2014-06-13T19:42:42Z : No. of bitstreams: 1 bellini_mf_dr_sjrp.pdf: 4712849 bytes, checksum: eaed69017a355062338fd2f384e1c381 (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O carcinoma de esôfago apresenta um modelo de progressão tumoral a partir da seqüência esofagite, atrofia, displasia, carcinoma

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31

Santos, André Bandiera de Oliveira. "Expressão imuno-histoquímica das proteínas p16, ciclina D1, CDK4, pRb, p53 e p21 em melanomas cutâneos de cabeça, pescoço e tronco e sua relação com prognóstico." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-21062010-171113/.

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O melanoma cutâneo é a neoplasia de pele de maior mortalidade. A imprevisibilidade de sua evolução é uma de suas características principais, o tratamento do tumor primário é, atualmente, de pouca morbidade e, na doença disseminada, as opções terapêuticas são pouco eficazes. É fundamental a pesquisa de marcadores tumorais que permitam a previsão da evolução, melhor compreensão da patogênese do melanoma e possibilitem a descoberta de alvos moleculares. Nesse contexto, estudos genéticos mostraram a importância da regulação do ciclo celular, especialmente a passagem da fase G1-S. Importantes fator

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32

Bellini, Marilanda Ferreira. "Estudos imuno-histoquímico das proteínas p53, p16, Fhit, caspase 3 e antígeno Ki67 ; e citogenético molecular em lesões benignas e carcinoma de esôfago /." São José do Rio Preto : [s.n.], 2009. http://hdl.handle.net/11449/102727.

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Resumo: O carcinoma de esôfago apresenta um modelo de progressão tumoral a partir da seqüência esofagite, atrofia, displasia, carcinoma in situ e carcinoma invasivo, com algumas alterações genéticas bem estabelecidas nos estágios iniciais e avançados da carcinogênese.Contudo em lesões benignas precursoras como o megaesôfago e esofagite crônica os estudos genéticos são escassos. Portanto, com o objetivo de identificar o envolvimento de algumas proteínas que participam da regulação do ciclo celular e apoptose, no presente estudo foi avaliada a expressão das proteínas p53, p16, Fhit, caspase-3 e

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33

Catani, João Paulo Portela. "Terapia gênica do câncer associando reparo da via p53 à imunoestimulação por IFNbeta." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-26112014-100519/.

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Os avanços científicos das últimas décadas permitiram que a compreensão do câncer evoluísse de uma visão simplista, na qual o principal motor seria uma atividade celular hiperploriferativa, para uma visão mais complexa onde o estado fisiológico geral permite a gênese e progressão tumoral. Essa evolução permite o desenvolvimento de novas abordagens terapêuticas e traz novas esperanças para o tratamento de muitos tipos de cânceres ainda extremamente deletérios. Dentro desse novo panorama, terapias que estimulem a imunidade antitumoral têm se mostrado extremamente promissoras. Nesse trabalho, pro

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34

Nair, Amrithraj Muraleedharan. "Studies of retroviral vectors for in utero gene transfer and investigation of calcium-mediated gene regulation by Human T-lymphotropic virus type-1." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1088785797.

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35

Lima, Marcos Antonio Pereira de. "Carcinoma de células escamosas oral: relevância do Papiloma vírus humano (HPV) e do vírus Epstein-Barr (EBV) na expressão de proteinas p16INK4a, E-caderina, COX-2, MLH1, p53 e MYC." reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/17048.

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LIMA, Marcos Antonio Pereira de. Carcinoma de células escamosas oral: relevância do Papiloma vírus humano (HPV) e do vírus Epstein-Barr (EBV) na expressão de proteinas p16INK4a, E-caderina, COX-2, MLH1, p53 e MYC. 2013. 180 f. : Tese (doudorado) - Universidade Federal do Ceará, Programa de Pós-Graduação em Biotecnologia, Rede Nordestes de Biotecnologia -Renorbio, Fortaleza-CE, 2013.<br>Submitted by demia Maia (demiamlm@gmail.com) on 2016-05-27T13:30:28Z No. of bitstreams: 1 2013_tese_maplima.pdf: 16584856 bytes, checksum: 9b25880d41a42f87ebcd6222528b072e (MD5)<br>Approved for entry into archiv

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Deleye, Yann. "Rôle du gène suppresseur de tumeur p16INK4a dans le métabolisme hépatique des lipides au cours du jeûne." Thesis, Lille 2, 2018. http://www.theses.fr/2018LIL2S002.

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Plusieurs études génétiques d’association de gènes ont mis en évidence le locus CDKN2A, codant notamment la protéine p16INK4a (p16), un gène suppresseur de tumeur, comme étant associé au risque de développement du diabète de type 2 (T2D) et des maladies cardiovasculaires. Le T2D, caractérisé par une hyperglycémie et/ou une insulinorésistance, s’accompagne fréquemment d’une stéatose hépatique prédisposant au développement de la NASH (Non Alcoholic Steatohepatitis), et contribuant à un risque accru de complications cardiovasculaires. Nous avons montré que la déficience de p16 augmente la néogluc

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37

Roof, Richard W. "C-SRC phosphorylation of P190 RHOGAP : regulation of P190/P120 RASGAP interaction /." 1999. http://wwwlib.umi.com/dissertations/fullcit/9916398.

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Wang, Li-Ya. "Molecular dissection of the TMV-encoded p126 protein in suppression of virus-induced gene silencing." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2206200718455900.

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39

Freedberg, D. E., S. H. Rigas, J. Russak, et al. "Frequent p16-independent inactivation of p14ARF in human melanoma." 2008. http://hdl.handle.net/10454/5973.

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BACKGROUND: The tumor suppressors p14(ARF) (ARF) and p16(INK4A) (p16) are encoded by overlapping reading frames at the CDKN2A/INK4A locus on chromosome 9p21. In human melanoma, the accumulated evidence has suggested that the predominant tumor suppressor at 9p21 is p16, not ARF. However, recent observations from melanoma-prone families and murine melanoma models suggest a p16-independent tumor suppressor role for ARF. We analyzed a group of melanoma metastases and cell lines to investigate directly whether somatic alterations to the ARF gene support its role as a p16-independent tumor suppresso

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40

Scozzai, Corinne [Verfasser]. "Immunhistochemische Analyse des p16-Proteins bei Patientinnen mit primärem Mammakarzinom und seine prognostische Relevanz / vorgelegt von Corinne Scozzai." 2006. http://d-nb.info/982791097/34.

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Jiang, Wen-Hong, and 姜文弘. "The comparison of cyclin D1, p16, and Ki-67 proteins in urothelial carcinoma of blackfoot and non-blackfoot disease areas." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/68258767875058583105.

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碩士<br>高雄醫學大學<br>醫學研究所<br>96<br>Objective: The aim of the study is to investigate the expression of cyclin D1, p16, Ki-67 proteins between urothelial carcinoma of arsenic-contaminated area (blackfoot disease) and non arsenic-contaminated area (non blackfoot disease) and different arsenic concentration in SV-HUC-1 cell lines (SV-40 immortalized human uroepithelial cell line). In order to evaluate the role of these proteins in arsenic carcinogenesis of urothelial carcinoma. Materials and methods: The tissue sections of urothelial carcinoma in 34 patients are composed of blackfoot disease

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