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Dissertations / Theses on the topic 'Proteins crystal structure'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Sadow, Jennifer Beth Hurley. "The X-ray crystal structure of wheat translation initiation factor eIF4E /." Thesis, Full text (PDF) from UMI/Dissertation Abstracts International, 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3085056.

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2

Zuccola, Harmon Jay. "The crystal structure of monoferric human serum transferrin." Diss., Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/26304.

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3

Carmel, Andrew Barry. "Crystal structure of BstDEAD, a novel DEAD-box protein from Bacillus stearothermophilus /." view abstract or download file of text, 2003. http://wwwlib.umi.com/cr/uoregon/fullcit?p3095239.

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Thesis (Ph. D.)--University of Oregon, 2003.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 101-114). Also available for download via the World Wide Web; free to University of Oregon users.

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4

Hoang, Quyen Quoc Yang Daniel. "Crystal structure and hydroxyapatite binding of porcine osteocalcin /." *McMaster only, 2003.

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5

Li, Xuchu. "Crystal structure of the kelch domain of human keap1." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/5828.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.

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6

Badger, J. "X-ray crystallographic studies of cubic insulin and of the ribosomal proteins L30 and S5." Thesis, University of York, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.483027.

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7

Herman, Moreno Maria Dolores. "Structural studies of proteins in apoptosis and lipid signaling." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8212.

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Signaling pathways control the fate of the cell. For example, they promote cell survival or commit the cell to death (apoptosis) in response to cell injury or developmental stimuli, decisions, which are vital for the proper development and functioning of metazoan. Tight control of such pathways is essential; dysregulation of apoptosis can disrupt the delicate balance between cell proliferation and cell death ending up in pathological processes, including cancer, autoimmunity diseases, inflammatory diseases, or degenerative disorders. We have used a structural genomic approach to study the stru

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8

Isaza, Clara Eugenia. "Biochemical and structural characterization of novel metalloprotein sensors and carboxypeptidases." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117548268.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xi, 98 p.; also includes graphics. Includes bibliographical references (p. 93-98). Available online via OhioLINK's ETD Center

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9

Galius, Veniamin. "Automated assignment of amide resonances in NMR spectra of proteins with known crystal structure /." [S.l.] : [s.n.], 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18043.

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10

Delarbre, Laure. "The crystal structure of Azotobacter vinelandii ModG provides insights into the mechanism and specificity of molybdate binding." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364998.

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11

Xu, Guozhou. "Crystal structures of the Fanconi anemia proteins : structure of the interstrand cross-linking repair protein Fanconi anemia protein I (FANCI); structure of the human FANCF C-terminal domain; reconstitution and crystallilzation of the sub-complexes in the Fanconi anemia core complex /." Access full-text from WCMC, 2009. http://proquest.umi.com/pqdweb?did=1692100351&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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12

Brown, Monica Anne. "Structural and functional analysis of bone morphogenetic proteins crystal structure of bone morphogenetic protein-9, binding studies with pro-domain and receptors, and mutational studies in Drosophila decapentaplegic /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3304428.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed June 18, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 62-72).

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13

Johnson, Matthew C. "Identifying key factors in two-dimensional crystal production and sample preparation for structure-function studies of membrane proteins by cryo-EM." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52974.

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Electron crystallography of two-dimensional crystals is a structure-determination method well suited to the study of membrane protein structure-function. Two-dimensional crystals consist of ordered arrays of protein within reconstituted lipid bilayers, an arrangement that mimics the natural membrane environment. In this work we describe our recent progress in the use of this method with three different proteins, each providing a window into a separate paradigm in the electron crystallographic pipeline. Specific crystallization conditions for human leukotriene C₄ synthase (LTC₄S) have previousl

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14

Rodríguez, Solovey Leisa Natacha. "IDENTIFICATION OF TARGETS AND AUXILIARY PROTEINS OF PYR/PYL/RCAR ABA RECEPTORS: PROTEIN PHOSPHATASES TYPE 2C (PP2Cs) AND C2-DOMAIN ABA-RELATED PROTEINS (CARs)." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/58862.

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[EN] ABSTRACT Abscisic acid (ABA) signaling plays a critical role in regulating root growth and root system architecture. ABA-mediated growth promotion and root tropic response under water stress are key responses for plant survival under limiting water conditions. In this work, we have explored the role of Arabidopsis (Arabidopsis thaliana) PYR/PYL/RCAR receptors (PYRABACTIN RESISTANCE1 (PYR1)/PYR1 LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS) for root ABA signaling. As a result, we discovered that PYL8 plays a nonredundant role for the regulation of root ABA sensitivity. Unexpectedly,

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15

Conti, Elena Eliana. "Crystal structure of firefly luciferase." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244284.

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16

Bakali, Amin. "Structural studies of three cell signaling proteins : crystal structures of EphB1, PTPA, and YegS." Doctoral thesis, Stockholm University, Department of Biochemistry and Biophysics, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6577.

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<p>Kinases and phosphatases are key regulatory proteins in the cell. The disruption of their activities leads ultimately to the abolishment of the homeostasis of the cell, and is frequently correlated with cancer. EphB1 is a member of the largest family of receptor tyrosine kinases. It is associated with neurogenesis, angiogenesis, and cancer. The cytosolic part of the human EphB1 receptor is composed of two domains. Successful generation of soluble constructs, using a novel random construct screening approach, led to the structure determination of the kinase domain of this receptor. The nativ

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17

Toro, Imre. "Crystal structures of two nucleic acid-binding proteins." Thesis, Open University, 2000. http://oro.open.ac.uk/58089/.

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The Crystal Structure of Sl Nuclease from Aspergillus oryzae S 1 nuclease from Aspergillus oryzae is a glycoprotein of 32 kDa molecular weight. The protein has two enzymatic activities: it is an endo-exonuclease with high specificity for single stranded nucleic acids, and it has an additional 3' -nucleotidase activity. S 1 nuclease is widely used in molecular biology as a single-strand specific nuclease due to its high stability and efficiency. It cleaves single-stranded regions of nucleic acids producing 5' -nucleotides without significant side-reactions. The crystal structure of S 1 nuclease

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18

Frouws, Timothy Duncan. "Iterative helical real-space reconstruction of histone octamer tubular crystals and implications for the 30 nm chromatin fiber." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&amp.

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19

Bakali, Amin. "Structural studies of three cell signaling proteins : crystal structures of EphB1kinase domain, PTPA, and YegS /." Stockholm : Department of Biochemistry and Biophysics, Stockholm university, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6577.

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20

O'Farrell, Heather Colleen. "The KsgA methyltransferase: Characterization of a universally conserved protein involved in robosome biogenesis." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/962.

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The KsgA enzymes comprise an ancient family of methyltransferases that are intimately involved in ribosome biogenesis. Ribosome biogenesis is a complicated process, involving numerous cleavage, base modification and assembly steps. All ribosomes share the same general architecture, with small and large subunits made up of roughly similar rRNA species and a variety of ribosomal proteins. However, the fundamental assembly process differs significantly between eukaryotes and eubacteria, not only in distribution and mechanism of modifications but also in organization of assembly steps. Despite the

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21

Pascal, John Matteson. "Crystal structures of ebulin, a non-toxic ribosome-inactivating protein /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p004355.

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22

Park, Jung Hee. "Crystal structure of ligand-free G-protein-coupled receptor opsin." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16049.

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Rhodopsin ist als Sehpigment der Photorezeptorzellen einer der am aktivsten untersuchten GPCRs. Es besteht aus dem Apoprotein Opsin und dem inversen Agonisten 11-cis-Retinal. Der inaktivierende Ligand ist in der sieben Transmembran- Helix (TM)-Struktur des Rezeptors kovalent gebunden und muss durch Licht cis/trans-isomerisiert werden, um den Rezeptor zu aktivieren. Der aktivierte Rezep-tor katalysiert den Nukleotidaustausch im G-Protein und zerfällt innerhalb von Minuten in Opsin und all-trans-Retinal. Das visuelle Pigment wird dann durch erneute Beladung des Opsins mit 11-cis-Retinal wieder

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23

Yunkun, Wu. "X-ray crystal structures of yeast heat shock proteins and mitochondrial outer membrane translocon member Tom70p." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/wu.pdf.

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24

Cordell, Suzanne Claire. "Crystal structures of the bacterial cell division proteins MinC and MinD." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620177.

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25

Lountos, George Themistoclis. "Structural and Mechanistic Insights From High Resolution Crystal Structures of the Toluene-4-Monooxygenase Catalytic Effector Protein, NAD(P)H Oxidase and Choline Oxidase." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7633.

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X-ray crystallography provides detailed information of the atomic structure of macromolecules that aides in the understanding of their molecular function. In this study, the three-dimensional structures of the Toluene-4-monooxygenase catalytic effector protein (T4moD), NAD(P)H oxidase and choline oxidase were determined. The structures of wild-type and two mutant isoforms of T4moD were solved up to 1.7 resolution. Results from the crystallographic studies indicate that there are significant differences between the X-ray structure and the structure previously solved by NMR. The high-resolutio

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26

Tsuboi, Chiaki. "X-ray crystal structure analyses of magnetically oriented microcrystalline suspensions." Kyoto University, 2016. http://hdl.handle.net/2433/216190.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19936号<br>農博第2186号<br>新制||農||1044(附属図書館)<br>学位論文||H28||N5009(農学部図書室)<br>33022<br>京都大学大学院農学研究科森林科学専攻<br>(主査)教授木村恒久, 教授西尾嘉之, 教授髙野俊幸<br>学位規則第4条第1項該当

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27

Francuski, Djordje [Verfasser]. "The crystal structure of MjRelBE protein complex from Methanococcus jannaschii / Djordje Francuski." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023623846/34.

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28

Jeong, Dae Gwin. "Crystal structures of dual specific protein phosphatases and insight into function of protein tyrosine phosphatase." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/136974.

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29

Chang, Tao-Hsin. "Structural studies of Norrin dependent Wnt/beta-catenin signaling." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a9f2d687-e8ee-4f26-9a8a-12efb87445ae.

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Norrin is a secreted cystine-knot growth factor that plays critical roles in vascular development in the brain, retina, and cochlea, as well as the uterus. Although Norrin is unrelated to the lipid-modified morphogens Wnts, Norrin activates the canonical Wnt/β-catenin pathway by binding to receptor Frizzled4 cysteine-rich domain (Fz4-CRD) and co-receptors of low density lipoprotein receptor related protein 5/6 ectodomain (Lrp5/6-ECD) in conjunction with Tetraspanin-12 (Tspan-12). Like Wnts, Norrin has limited extracellular diffusion properties as a result of associating with heparan sulfa

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30

Ribeiro, Diana de Oliveira. "Using gold nanoparticles in protein crystallography: studies in crystal growth and derivatization." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8148.

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Dissertation for the Master Degree in Structural and Functional Biochemistry<br>In the field of protein structural analysis, X-ray crystallography plays a major role to expand the knowledge on how proteins function, as well as their interactions with other molecules. However, several obstacles can be present when attempting to grow protein crystals and subsequently determine its structure. Therefore, strategies that facilitate the production of suitable crystals for X-ray diffraction techniques, such as nucleating agents, or that allow overcoming the phase problem, as the production of heav

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31

Clairmont, François. "Structure of the insecticidal crystal protein from Bacillus thuringiensis var. kurstaki HD-73." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/NQ48094.pdf.

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32

Nagpal, Akanksha. "Crystal Structures of Nitroalkane Oxidase: Insights into the Structural Basis for Substrate Specificity and the Catalytic Mechanism." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-07172005-152826/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2006.<br>Dr. Allen M. Orville, Committee Chair ; Dr. Loren D. Williams, Committee Member ; Dr. Donald F. Doyle, Committee Member ; Dr. Dale E. Edmondson, Committee Member ; Dr. Giovanni Gadda, Committee Member.

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33

Dubey, Rashmi. "Deciphering the mechanism and function of stage-specific protein association with the membrane cytoskeleton of Toxoplasma gondii:." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107315.

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Thesis advisor: Marc-Jan Gubbels<br>Apicomplexan parasites like Toxoplasma gondii have a complex life cycle comprising of transitions between different hosts, different organ systems and between the extracellular and intracellular milieu. The parasite must thus adjust itself and its cellular processes in accordance with its environment. In this dissertation, I have focused on such stage specific behaviors of three distinct intermediate filament-like proteins as well as a glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase 1 (GAPDH1). These proteins relocate from the cytosol to the uniq

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34

Buhrman, Gregory Kale. "Application of the Multiple Solvent Crystal Structures Method to Analyze the Protein Binding Surface of H-Ras Protein." NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-05022005-064543/.

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H-Ras is a member of the small, monomeric GTPase protein superfamily. H-Ras functions as a ?molecular switch?, using nucleotide dependent conformational changes to relay signals in a number of signal transduction pathways. Mutations in codons 12, 13 and 61 creates an oncogenic version of the protein which does not hydrolyze GTP, resulting in the constitutive activation of downstream effector proteins. Ras proteins participate in multiple protein : protein interactions in the cell, making Ras a good candidate protein to extend the Multiple Solvent Crystal Structures method (MSCS) to the analysi

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35

Ma, Qingjun. "Crystal structure of wind, a PDI-related protein required for Drosophila melanogaster dorsal-ventral development." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970195044.

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36

Apgar, Marc C. "The influence of pH on nucleation, solubility and structure of lysozyme protein crystals." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002520.

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37

Hanazono, Yuya. "Structural studies on the mechanism of protein folding." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188506.

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38

Zhang, Ruojing. "The Investigation of Biophysical and Biological Function of PRPS from Nostoc PCC 7120." Miami University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1617630241200474.

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39

Andersson, Charlotta. "Structural studies of Erwinia carotovora L-Asparaginase by X-ray crystallography." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6188.

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<p>Bacterial L-asparaginases (E.C.3.5.1.1) are enzymes that catalyze the hydrolysis of L-asparagine to aspartic acid. For the past 30 years these enzymes have been used as therapeutic agents in the treatment of acute childhood lymphoblastic leukemia. The presence of a low rate glutaminase activity however causes serious side-effects to patients in treatment, as glutamine depletion give rise to neurotoxicity, anaphylaxis, and other hypersensitivity reactions. The interest in the enzyme from Erwinia carotovora originates from the fact that it shows a decreased glutaminase activity, and therefore

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40

Rule, S. A. R. "Synchrotron X-radiation protein crystallography and its use in the crystal structure determination of purine nucleoside phosphorylase." Thesis, Keele University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235339.

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41

Eklund, Malin. "Combinatorial protein engineering applied to enzyme catalysis and molecular recognition." Doctoral thesis, KTH, Biotechnology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3721.

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<p>The recent development of methods for constructing andhandling large collections (libraries) of proteins, from whichvariants with desired traits can be isolated, hasrevolutionized the field of protein engineering. Key elementsof such methods are the various ways in which the genotypes(the genes) and the phenotypes (the encoded proteins) arephysically linked during the process. In one section of thework underlying this thesis, one such technique (phagedisplay), was used to isolateand identify protein librarymembers based on their catalytic or target molecule-bindingproperties.</p><p>In a fir

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42

Ramadan, Mohamed Abbas Mohamed. "The three dimensional structure of calcium depleted human C-reactive protein from perfectly twinned crystals." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391955.

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43

Chang, Eric P. "The Rational Design of Coiled-Coil Peptides towards Understanding Protein-Crystal Interactions and Amorphous-to-Crystalline Transitions." Bowling Green State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1363258701.

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44

Diller, Thomas Cabot. "Crystal structure of a deletion mutant of the type II[beta] regulatory subunit of cAMP-dependent protein kinase /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9970670.

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Eddy, Matthew T. (Matthew Thomas). "Magic angle spinning NMR applied to membrane protein 2D crystals : the structure and function of VDAC." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73355.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2012.<br>"June 2012." Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Membrane proteins mediate critical functions in biological systems and are important drug targets for a number of diseases. Determining the three-dimensional structure and function of membrane proteins under physologically relevant conditions is a long sought-after goal in structural biology. In pursuit of this objective we have applied Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR) to investigate the

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Huang, Kerwyn Casey 1979. "The rise and fall of structure in physics : polaritonic photonic crystals, melting, and min-protein oscillations." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28642.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2004.<br>Includes bibliographical references (p. 187-197).<br>This thesis is a compilation of theoretical and computational work in condensed matter physics related to three topics in structure development. First, I study photonic crystals composed of polaritonic media, focusing on the unique features of the band structures and Bloch states in dispersive media with and without losses. I discuss three novel localization phenomena in these structures: node switching, flux expulsion, and negative effective permeability. Sec

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47

Ahlstrom, Logan Sommers. "Molecular Dynamics Simulation of the Effect of the Crystal Environment on Protein Conformational Dynamics and Functional Motions." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/255200.

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Proteins are dynamic and interconvert between different conformations to perform their biological functions. Simulation methodology drawing upon principles from classical mechanics - molecular dynamics (MD) simulation - can be used to simulate protein dynamics and reconstruct the conformational ensemble at a level of atomic detail that is inaccessible to experiment. We use the dynamic insight achieved through simulation to enhance our understanding of protein structures solved by X-ray crystallography. Protein X-ray structures provide the most important information for structural biology, yet

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48

Kuehlmann, Ulrike. "The crystal structure of the complex of the Escherichia coli colicin E9 DNase domain with its cognate immunity protein Im9." Thesis, University of East Anglia, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266751.

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49

Sukackaitė, Rasa. "Structural and functional studies of the restriction endonuclease BpuJI." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20091215_091842-18511.

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Type II restriction endonucleases recognize specific DNA sequences and cleave DNA at fixed positions within or close to this sequence. BpuJI recognizes the 5’-CCCGT sequence, but in contrast to other enzymes its cleavage site is very variable. This study shows that BpuJI is a dimer in solution and consists of two separate domains. The N-domain binds to the target sequence as a monomer, while the C-domain is responsible for nuclease activity and dimerization. The nuclease activity is repressed in the apo-enzyme and becomes activated upon specific DNA binding by the N-domains. The activated C-do

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50

Shrestha, Manisha. "Mechanistic Studies of the Roles of the Transcriptional Activator ExsA and Anti-activator Protein ExsD in the Regulation of the Type Three Secretion System in Pseudomonas aeruginosa." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/95966.

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Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that is a substantial threat, particularly in hospital settings, causing severe infections in immunocompromised patients that may lead to death. Pseudomonas aeruginosa harbors a multitude of virulence factors that enable this pathogen to establish both acute and chronic infections in humans. A key determinant of acute infections is a hollow molecular needle structure used for injecting toxins into a host cell, called the type three secretion system (T3SS). The secretion machinery itself is highly complex and, together with the spe

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