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Dissertations / Theses on the topic 'Proteolyses'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Conseil, Valérie. "Etude des proteolyses en culture et in vitro de la proteine p126 de plasmodium falciparum." Lille 2, 1996. http://www.theses.fr/1996LIL2T007.

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2

Попадинець, Василь Миронович, Василий Миронович Попадинець, Vasyl Myronovych Popadynets та ін. "Нейтрофільна еластаза як показник стану протеолітичної системи у хворих з трофічними виразками різного генезу". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64749.

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Актуальність. Незважаючи на бурхливий розвиток сучасних наукових технологій і накопичений багаторічний досвід у вирішенні багатьох міждисциплінарних проблем, питання профілактики та лікування трофічних виразок залишаються актуальними. Серед основних причин виникнення виразок на нижніх кінцівках провідне місце займають розлади їх кровопостачання. Процеси протеолізу мають безпосереднє відношення до реакцій запалення і деструкції тканина. Недостатньо вивченим залишається стан протеолітичної системи у хворих із захворюваннями судин, а також трофічними виразками різного генезу. Останнім часом з’явл

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3

El-Daher, Marie-Thérèse. "Huntingtin proteolysis and toxicity." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T029/document.

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La maladie de Huntington (MH) est une maladie neurodégénérative héréditaire autosomique dominante. Elle est due à l’expansion anormale de polyglutamine dans la partie N-terminal de la protéine huntingtine (HTT). Une des étapes clés de la pathologie est le clivage de la HTT pleine longueur en fragments N-terminaux plus petits, contenant l’expansion de polyglutamine, et qui sont toxiques pour les neurones. En effet, les clivages de la HTT mutée génère des fragments N-terminaux (N-ter) de tailles comprises entre les acides aminés 1-105 et 1-586 observés dans des extraits de cerveaux de patients M

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4

Clay, L. "CDC20 function, regulation and proteolysis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597750.

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The destruction of mitotic cyclins and other key regulators uses ubiquitin mediated proteolysis controlled via the activation of the ubiquitin ligase the Anaphase Promoting Complex/Cyclosome (APC/C), and its adaptor proteins Cdc20 and Cdh1. The spindle assembly checkpoint coordinates the APC/C with microtubule attachment and sets the timing from NEBD to anaphase. Cdc20 is inactivated by the spindle assembly checkpoint to prevent premature anaphase onset. Once the spindle assembly checkpoint is satisfied, Cdc20 can be released and activate the APC/C. However, cyclin A is degraded independently

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5

Slee, Adrian. "Regulation of skeletal muscle proteolysis." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/13105/.

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Proteolysis is a component of protein turnover, controlled by multiple proteolytic systems. Alterations in system components within skeletal muscle has been associated with hypertrophy, remodelling, atrophy, apoptosis and metabolic dysregulation. Key components may have novel regulatory roles, e. g. calpain-3 and cathepsin-L. Experiments described within this thesis investigated the hypothesis that the gene expression of specific proteolytic system components within skeletal muscle may be co-ordinately regulated and altered during nutritional and pharmacological states known to modify protein

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6

Haas, Regina. "Proteolyse von Apolipoprotein A-I." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=956370217.

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7

Weimann, Dirk. "Proteolyse-induzierte Spaltprodukte des Plasminogens." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-3608.

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8

Slimani, Lamia. "Mécanismes impliqués dans l'atrophie et la récupération musculaire après immobilisation chez le rat. : Rôle des altérations de la matrice extracellulaire." Thesis, Clermont-Ferrand 1, 2012. http://www.theses.fr/2012CLF1MM21/document.

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Le muscle squelettique est le réservoir principal d’acides aminés libres de l’organisme. Ainsi, l’atrophie musculaire induite par l’immobilisation peut entraîner un affaiblissement et un allongement des périodes de récupération générant des coûts de santé publique élevés. Une aggravation de l’atrophie caractérise de façon surprenante le muscle tibialis anterior (TA) après le déplâtrage, retardant la récupération. Mon objectif a été de comprendre les mécanismes à l’origine de l’aggravation de l’atrophie du TA pendant les phases précoces de récupération en étudiant i) la structure et le phénotyp

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9

Ullrich, Oliver. "Mechanismen protektiver und destruktiver Funktionen der Poly(ADP-Ribose)-Polymerase-1 (PARP-1) bei Zell- und Gewebeschädigungen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13826.

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Während der letzten Dekade neurobiologischer Forschung wurde deutlich, dass inflammatorische Vorgänge in einem Netwerk nicht-neuronaler und neuronale Zellen wesentlich zur Entstehung und zur Progredienz einiger wichtiger neurodegenerativer Erkrankungen beitragen. Therapeutische Ansätze sollten daher auch auf die Protektion initial überlebender Neurone vor dieser sekundären inflammatorischen Schädigung zielen. Ein wesentlicher Bestandteil dieser sekundären Schädigung besteht aus der Migration von Makrophagen und Mikrogliazellen in die Regionen neuronaler Schädigung, wo sie grosse Mengen an toxi

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10

Andréasson, Claes. "Ligand-activated proteolysis in nutrient signaling /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-075-3/.

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11

Hutton, David Alan. "Studies on mucin isolation and proteolysis." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287272.

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12

Canning, Mary. "Ubiquitin-mediated proteolysis and Drosophila embryogenesis." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/13305.

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Ubiquitination provides a means of rapidly and irreversibly eliminating an unwanted protein from the cell, and is therefore a potentially effective tool for regulating cellular behaviour. Ubiquitin-mediated proteolysis is involved in such diverse physiological functions as growth control, cell signalling, differentiation and the immune response. The aim of this research has been to investigate its role in <i>Drosophila </i>embryogenesis. Protein ubiquitination is a stepwise process carried out by three classes of enzyme known as E1s, E2s and E3s. The E1 (ubiquitin-activating enzyme), generates

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13

Smith, Kate L. "Tumour associated proteolysis and protein metabolism." Thesis, Aston University, 1992. http://publications.aston.ac.uk/12604/.

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The effect of cancer cachexia on protein metabolism has been studied in mice transplanted with the MAC16 adenocarcinoma. The progressive cachexia induced by the MAC16 tumour was characterised by a reduction in carcass nitrogen between 16-30% weight loss and a reciprocal increase in tumour nitrogen content. Carcass nitrogen loss was accompanied by a concomitant decrease in gastrocnemius muscle weight and nitrogen content and also by a decrease in liver nitrogen content. The loss of gastrocnemius muscle throughout the progression of cachexia was attributable to a 60% decrease in the rate of prot

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14

Lemberg, Marius Kaspar. "Intramembrane proteolysis by the aspartic protease SPP /." Zürich, 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15327.

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15

Potocka, Isabel. "Cell-cycle regulated proteolysis in Caulobacter crescentus." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252229.

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16

Campbell, William. "Characterisation of the proteolysis of chromogranin A." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301777.

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17

Taxis, Christof. "Proteinqualitätskontrolle im endoplasmatischen Retikulum: Variationen im Abbaumechanismus von löslicher und membrangebundener missgefalteter CarboxypeptidaseY (CPY*)." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10252251.

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18

Kanow-Scheel, Christine. "Regulation der Proteolyse des Masterregulators der generellen Stressantwort RpoS (σs) während des Wachstumszyklus von Escherichia coli". Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2017. http://dx.doi.org/10.18452/17735.

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Der alternative Sigmafaktor RpoS ist der Masterregulator der generellen Stressantwort in Escherichia coli. Er kontrolliert ein Regulon von mehr als 500 Genen. In ungestressten Zellen ist die RpoS-Synthese gering, da RpoS nach Bindung an den spezifischen Erkennungsfaktor RssB von der ClpXP-Protease unter ATP-Verbrauch degradiert wird. RssB wird dabei nicht codegradiert und wirkt daher katalytisch. In gestressten Zellen wird RpoS stabilisiert. Die zentrale Fragestellung dieser Arbeit war, wann und wodurch RpoS in den beiden E. coli K12-Laborstämmen W3110 und MC4110 stabilisiert wird. Die Ergebni

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19

Brose, Michael C. "Fujinami sarcoma virus P140 proteolysis and peptide purification." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24487.

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Fujinami sarcoma virus encodes a 140/000 m.w. polypeptide (P140) which has been correlated as the agent of transformation in host chicken fibroblasts and mammalian fibroblasts. To conclusively identify the role of P140 in the transformation process it will be necessary to obtain intact/ purified P140. The availability of an antibody monoclonally specific to the N-terminal gag encoded portion of P140 suggested a one-step immunoaffinity purification of P140. After purification of the antibody out of mouse ascites fluid, by 50% ammonium sulfate fractionation and ion exchange chromatography, antib

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20

Zhang, Ying. "Function of SPX and its control by proteolysis /." Full text open access at:, 2007. http://content.ohsu.edu/u?/etd,264.

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21

Fairbairn, Robert L. "Proteolysis associated with the fermentation of ensiled forage." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75861.

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Chopped alfalfa and chopped whole-plant corn were ensiled and the proteolytic changes which occurred during ensiling were investigated. Proteolysis was measured in terms of end-products of protein degradation and by protein isolation followed by electrophoresis. The effects of formic acid and ammonia, applied at the time of ensiling, on proteolytic changes were investigated.<br>Alfalfa treated with formic acid contained significantly reduced levels of NH$ sb3$-N and NPN compared to control silage; ammonia (NH$ sb3$)-treated alfalfa silage had significantly less NPN (P $<$ 0.05). After 90d of s

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22

Stanton, Catherine. "Proteolysis-induced changes in meat collagen during conditioning." Thesis, Bournemouth University, 1988. http://eprints.bournemouth.ac.uk/298/.

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Changes in intramuscular connective tissue brought about by conditioning were investigated in bovine muscles of different quality. Perimysial and endomysial collagens were solubilized to a small extent during conditioning and residual insoluble collagens in both connective tissue domains were damaged by proteolytic processing. Yields of soluble perimysial material from unconditioned muscles were significantly lower (p = 0.096) than from conditioned muscles. Solubilized perimysial collagen from unconditioned muscles was significantly lower (p = 0.015) than from conditioned muscles with 1±0.8 %

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23

Rusbridge, Nicholas Mercer. "Tryptic proteolysis of glycogen phosphorylase b in vitro." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317367.

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24

Newman, Andrew. "The regulation of L-selectin activity by proteolysis." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/103855/.

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L-selectin (CD62L) is a type I transmembrane protein expressed by lymphocytes which directs their migration from the bloodstream into lymph nodes and infected tissues. Stimulation of the T cell receptor (TCR) activates the enzyme A Disintegrin and Metalloproteinase 17 (ADAM 17), which cleaves L-selectin at the ectodomain generating a metalloproteinase product (MP product) comprising of a transmembrane region and a 17-amino acid intracellular domain (ICD). ϒ-secretase is a multi-subunit protease that cleaves up to 90 identified type I transmembrane proteins in the intramembrane region following

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25

Zahn, Claudia [Verfasser]. "Regulierte intramembranäre Proteolyse des Transferrinrezeptors 1 / Claudia Zahn." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1050709543/34.

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26

Roscher, Simone. "Ablauf und Beeinflussungsmöglichkeiten der Proteolyse während der Silierung von Weidelgras und Luzerne." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/18816.

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Tannine gehören zu den phenolhaltigen Verbindungen und galten in der Tierernährung bisher als sekundäre unerwünschte Pflanzeninhaltsstoffe. Sie werden in der Regel in zwei Hauptgruppen eingeteilt: kondensierte und hydrolisierbare Tannine. Im Mittelpunkt der vorliegenden Untersuchungen stand die Quantifizierung der Reduzierung der Proteolyse während der Silierung in Folge der Zulage von tanninhaltigen Pflanzenextrakten unterschiedlicher Herkunft zum Siliergut. Zu diesem Zweck wurden zunächst in Silierversuchen zwei tanninhaltige Pflanzenextrakte unterschiedlicher botanischer Herkunft (Mimosa

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27

Fraser-Smith, Emma Louise. "Characterizing the Catalytic Action of μ-Calpain on Myofibrillar Protein Structure". The University of Waikato, 2006. http://hdl.handle.net/10289/2253.

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Solving the problem of inconsistent meat tenderness is a top priority of the meat industry. This requires a greater understanding of the processes that affect meat tenderness and the adoption of such information by the meat industry. It is essential that we understand the mechanism of meat tenderisation of which, the calpain protease system is believed to play a central role. This thesis focuses on three aspects; characterisation of calpain activity, the effect of porcine μ-calpain on myofibril degradation and the effect of μ-calpain on specific proteins desmin and troponin-T. To study the eff

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28

Alban, Andrew. "The interactions of ubiquiton-containing proteins with S5a and the 26S proteasome." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323187.

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29

Sivertsson, Elin Maria. "Enzymatic degradation of topologically simple and complex proteins." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708862.

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30

Rozkov, Aleksei. "Control of Proteolysis of Recombinant Proteins in Escherichia coli." Doctoral thesis, KTH, Biotechnology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3227.

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31

Solomonson, Matthew Morris. "Structure, proteolysis, and evolution of secreted tuberculosis virulence factors." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54572.

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Mycobacterium tuberculosis uses the ESX-1 type VII secretion system to export proteins to its cell surface, which permeabilize the host macrophage phagosomal membrane, allowing the bacterium to escape and spread to new cells. The structure of the type VII membrane complex and how it mediates this function is unknown, but it is hypothesized that some of the secreted proteins form an extracellular appendage that facilitates membrane lysis or direct secretion of virulence factors into the host cytoplasm. This thesis investigates the structural relationship between one of these secreted proteins,

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32

Chove, Lucy Mlipano. "Detection of proteolysis in milk by four selected methods." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515687.

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33

Cooke, F. M. "The role of localisation in regulating proteolysis in mitosis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597941.

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In order to maintain genetic fidelity and to avoid aberrant proliferation, the cell cycle must be carefully regulated. Progression through mitosis is controlled by ubiquitin-mediated proteolysis of cell cycle proteins, allowing each stage in the cell division process to begin only when the previous stage is successfully completed and the various checkpoints are satisfied. As proteolysis contributes to the correct timing of exit from mitosis and cytokinesis, I have investigated the mechanisms responsible for degrading specific proteins at specific times during the cell cycle and how this is reg

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34

Brown, Geraldine Marie. "Extracellular matrix proteolysis by bronchoalveolar leukocytes in experimental pneumoconiosis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19447.

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Neutral proteinases, released by inflammatory leukocytes, have been implicated in the pathogenesis of pneumoconiosis but there has been no systematic study of the proteolytic acitivty of leukocytes from dust-exposed lung. The aim of the present study was, therefore, to assess the bronchoalveolar leukocyte profile and proteolytic activity of the leukocytes in a rat model of pneumoconiosis. An assay, based on the breakdown of [<SUP>125</SUP>I] fibronectin, that would measure the overall proteolytic activity of the bronchoalveolar leukocytes and indicate their potential to damage the connective t

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35

McKinnon, Thomas Antony Jude. "Von Willebrand factor glycans : modifiers of function & proteolysis." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/7380.

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36

Rabe, Linnea. "Regulierte intramembranäre Proteolyse von Typ I Neuregulin 1-β". Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-164228.

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Vielversprechende Therapieansätze für die Alzheimer Erkrankung basieren auf der Amyloid-Hypothese und beinhalten die Inhibition der β-Sekretase BACE1 und des γ-Sekretase-Komplexes sowie die Aktivierung der α-Sekretase ADAM10. Für die Einschätzung und Minimierung von Nebenwirkungsprofilen ist die Kenntnis weiterer Substrate dieser Sekretasen essentiell. Als ein solches Substrat wurde Typ I Neuregulin1-β (Typ I NRG1-β), ein Mitglied der EGF-Familie von Wachstumsfaktoren, vermutet. In der vorliegenden Arbeit konnte in vitro gezeigt werden, dass Typ I NRG1-β ein Substrat für den γ-Sekretase-Komp

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37

Raab, Christian [Verfasser]. "Untersuchungen zur Proteolyse des spannungsabhängigen Kaliumkanals Kv7.1 / Christian Raab." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1153768488/34.

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38

Metodiev, Metodi Dimitrov. "Role of prohibitins for proteolysis in yeast and murine mitochondria /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979125634.

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39

Sherman, Robyn. "Regulation of Histone H3 Proteolysis by Acetylation in Tetrahymena thermophila." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/598.

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Chromatin is the combination of DNA and proteins in the nucleus that is used to aid in the compaction of DNA. Histones are a group of proteins used to condense DNA by forming a complex (nucleosome) around which DNA wraps around; there are two of each type of histone in a nucleosome: H2A, H2B, H3 and H4. Once the DNA is wrapped around the histones, the genome is further compacted. A shortened, "clipped" version of histone H3 has been found in some organisms including yeasts, flies, mammalian stem cells, and the ciliated protozoan, Tetrahymena thermophila. In each organism, clipping occurs at a

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40

Lowrie, A. G. "Neoplastic expression and cellular functions of proteolysis inducing factor/dermcidin." Thesis, University of Edinburgh, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654076.

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Proteolysis inducing factor (PIF) is a pro-cachectic glycopeptide purified from the urines of mice inoculated with the MAC16 tumour and from the urines of weight losing patients with pancreatic carcinoma. It arises from the dermcidin gene which produces 2 other peptides, Y-P30, an unglycosylated neuronal survival factor with homology to the PIF peptide core and DCD-1, an antibiotic peptide secreted by eccrine sweat glands which has no homology with PIF. We sought to investigate PIF / dermcidin expression in cell lines and pancreatic carcinoma tissue, the role of proteolysis inducing factor as

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41

Kemp, Caroline. "The role of caspase-mediated postmortem proteolysis in meat tenderisation." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435987.

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42

Fung, Ella. "Fbxl13 regulates centrosome homeostasis and migration through ubiquitin mediated proteolysis." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:5f0198b9-eea7-486f-9860-d006b9ed80e7.

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Fbxl13 (F-box and leucine-rich repeat protein 13) is an orphan F-box protein. Fbox proteins are a family of substrate-targeting specificity factors for the SCF superfamily of E3 ubiquitin ligases. Since their discovery, many F-box proteins have been shown to have oncogenic and tumour suppressive roles. The importance of Fbxl13 itself in tumourigenesis is reflected in several genome-wide shRNA screens. Fbxl13 depletion in human cancer cells correlates with increased ionising radiation sensitivity and increased genomic instability. Furthermore, Fbxl13 depletion reduces proliferation in mouse emb

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43

Ivanushko, Ya G. "Laser radiation effect on the proteolysis state of rat liver." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18209.

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44

Moskaliuk, V. I., and I. I. Moskaliuk. "The role of proteolysis in development of intestinal contractility disorders." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16913.

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45

Mikulets, L. V. "Circadian rhythms of proteolysis indices in patients with rheumatoid arthritis." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18053.

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46

Kirsch, Richard. "Characterisation of fibrinogen and fibrin proteolysis by the neutrophil membrane." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26928.

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Recent studies have identified a novel 600 kDa neutrophil membrane associated protease which degrades fibrinogen, fibrin and C-reactive protein (CRP) during incubation of these ligands with phorbol 12-myristate 13-acetate (PMA, 5-10 ng/ml) stimulated neutrophils. This proteolysis is predominantly an extracellular event which occurs through a ligand dependent release of this protease from the neutrophil. Degradation products arising from this proteolysis not only become neutrophil associated but influence a number of important processes occurring in inflammation and coagulation. The aim of the

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47

Mikita, Natalie. "DEVELOP SPECTROSCOPIC APPROACHES TO STUDY NON-PROTEOSOMAL ATP-DEPENDENT PROTEOLYSIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1401814273.

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48

Mohammad, Kamaruzaman bin. "Proteolysis of zeins in the endosperm of germinating maize seeds." Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/53589.

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The pattern and sequence of zein degradation in the endosperm of germinating maize seeds were investigated by sodium dodecyl sulfate polyacrylamide gel electrophoresis and immunoblotting. The proteases involved in the degradation of various zein components (α, ß and γ) were extracted with three buffer systems and partially characterized with respect to their ability to degrade various zein components. They were also investigated in vivo by germinating the seeds in the presence of protease inhibitors used singly and in combination. Of the various zein components, γ-zein (27-kD) was the first

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49

Kim, Ikjin. "Roles of UBL domain containing proteins in proteolysis : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1490071661&sid=4&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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50

Chen, Beibei. "Novel mechanisms for enzymatic regulation of phosphatidylcholine synthesis by proteolysis." Diss., University of Iowa, 2008. https://ir.uiowa.edu/etd/199.

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Abstract:

Pulmonary surfactant is a critical surface-active substance consisting of dipalmitoylphosphatidylcholine (DPPtdCho) and key apoproteins that are produced and secreted into the airspace from alveolar type II epithelial cells. Surfactant deficiency leads to severe lung atelectasis, ventilatory impairment, and gas-exchange abnormalities. These are features of the acute lung injury syndrome, characterized by a strong pro-inflammatory component where cytokines or bacteria infections greatly impair surfactant DPPtdCho biosynthesis. The key enzyme needed to produce surfactant DPPtdCho is a rate-limit

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