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Dissertations / Theses on the topic 'Proteolytic enzymes'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ekici, Özlem Doğan. "Design, synthesis, and evaluation of novel irreversible inhibitors for caspases." Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04062004-164633/unrestricted/ekici%5Fozlem%5Fd%5F200312%5Fphd.pdf.

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2

Ekici, Ozlem Dogan. "Design, synthesis, and evaluation of novel irreversible inhibitors for caspases." Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5333.

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3

Ahmed, Naveed. "The synthesis of inhibitors of proteolytic enzymes." Thesis, University of Huddersfield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416765.

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4

Verity, Christiana Kelsick. "Cathepsin D-like aspartic protease from Schistosoma japonicum : developmental, enzymological and immunological studies /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16289.pdf.

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5

Chaveesuk, Ravipim. "Accleration of fish sauce fermentation using proteolytic enzymes." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60539.

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First grade and second grade Nampla, commercially produced Thai fish sauces, were analyzed for their chemical and microbiological composition. First grade commercially produced Nampla contained higher amounts of total nitrogen, formol nitrogen, free and total amino acids compared to second grade sauce. Most of the essential amino acids were present in both grades of sauces. Low microbial counts of halotolerant microorganisms were observed in both sauces. The use of trypsin and chymotrypsin to accelerate the rate of fish sauce fermentation produced from herring, one of the underutilized fish sp

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6

陳臻 and Chun Jade Chan. "Proteolytic enzyme in soy sauce fermentation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31223977.

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7

Chan, Chun Jade. "Proteolytic enzyme in soy sauce fermentation." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B22713384.

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8

Deane, Shelly May. "Molecular biology studies on the extracellular serine proteases of Vibrio alginolyticus." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/21895.

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Bibliography: pages 161-176.<br>Vibrio alginolyticus is a gram-negative aerobic bacterium that produces several extracellular serine proteases and a collagenase during the stationary growth phase. The aim of this study was to investigate alkaline serine protease production by this organism, and to attempt the cloning and expression of a V.alginolyticus protease gene in Escherichia coli.

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9

賴玉耀 and Yuk-yeu William Lai. "Identification and characterization of proteolytic enzymes in Trichinella spp." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31214228.

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10

Hinchliffe, Paul Stuart. "The synthesis of #beta#-sultam inhibitors of proteolytic enzymes." Thesis, University of Huddersfield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368328.

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11

Lai, Yuk-yeu William. "Identification and characterization of proteolytic enzymes in Trichinella spp /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19739898.

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12

Faro, Andrew. "Recombinant expression and full backbone assignment of the human DWNN using heteronuclear NMR." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The cellular levels of a number of proteins have been found to be regulated by the ubiquitin-proteasome pathway. In this pathway, proteins are covalently tagged (&ldquo<br>ubiquitinated&rdquo<br>) by ubiquitin, which acts as a signal for degradation by the proteasome. A number of key cellular processes, including cell-cycle progression, transcription and DNA repair, are regulated in this way. In recent years a number of cellular proteins resembling ubiquitin in structure or function, the so-called ubiquitin-like proteins, have been identified. Ubiquitin-like proteins can be divided into two cl

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13

Gordon, Nathaniel Charles. "Protease engineering for therapeutic applications." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648185.

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14

Duman, Ramona Elena. "Structural studies of bacterial Lon ATP-dependent proteases." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609086.

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15

Seo, Sang-Beom. "Purification and characterization of protease C2 : the protease which initiates the degradation of the B-subunit of B-conglycinin in soybean (Glycine max) seedlings /." Online version via UMI:, 1999.

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16

Dotse, Anthony Kwabla. "Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/29979.

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17

Cameron, Angus. "Proteolytic enzymes from the hepatopancreas of the Kamchatkan King crab." Thesis, London South Bank University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264822.

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18

Vaiyapuri, Sakthivel. "Sequence, structure and functional studies of viper venom proteolytic enzymes." Thesis, University of Reading, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501321.

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Snake venom proteins are potential sources for novel drug design both for treatment of snake bites and for human genetic disorders. To achieve these, the basic sequence, structure and functional relationships of venom proteins should be understood. Proteolytic enzymes such as metallo and serine proteases are the major components of venom in vipers and are responsible for local and systematic envenomation effects. We have purified, partially sequenced and functionally characterised a serine protease, rhinocerase from the venom of Bitis gabonica rhinoceros. Rhinocerase is a multifunctional enzym

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19

Deng, Meihong. "Proteolytic cleavage of FOXM1 by caspases /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36396503.

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20

Deng, Meihong, and 邓美虹. "Proteolytic cleavage of FOXM1 by caspases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010675.

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21

Saldanha, Rohit Gregory Medical Sciences Faculty of Medicine UNSW. "Proteolytic enzymes in grass pollen and their relationship to allergenic proteins." Awarded by:University of New South Wales. School of Medical Sciences, 2005. http://handle.unsw.edu.au/1959.4/20824.

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Pollen grains are ubiquitous triggers of allergic asthma and seasonal rhinitis. Proteolytic enzymes in pollen as well as other sources are capable of disrupting airway epithelial integrity in vivo and in vitro. This provides a plausible mechanism for the initiation of sensitisation of the respiratory immune system to inhaled pollen allergens, comparable to that suggested for Group 1 allergens from house dust mites and cat dander, which are known to possess intrinsic proteolytic activity. This thesis explores the relationship between pollen allergens and proteolytic enzymes. It describes the di

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22

Heidlebaugh, Nancy Marie. "Analysis of nitrogen reallocation from senescing barley leaves characterization of the influence of a high-grain protein content locus on chromosome six, and molecular cloning and heterologous expression of a serine carboxypeptidase /." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/heidlebaugh/HeidlebaughN0508.pdf.

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23

Lacroix-Desmazes, Sebastien. "Influence of flow environment on the production and secretion of metalloproteinases and urokinase-type plasminogen activator by cultured bovine aortic endothelial cells." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/15826.

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24

Ye, Yu. "Targeting ubiquitin chains with deubiquitinases." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610783.

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25

Gibb, Gregory Donald. "Physiological regulation of Streptomycete Proteases /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487327695620921.

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26

Gençkal, Hande Tarı Canan. "Studies On Alkaline Protease Production From Bacillus Sp./." [s.l.]: [s.n.], 2004. http://library.iyte.edu.tr/tezler/master/biyoteknoloji/T000505.pdf.

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27

Beaumont, Marie Louise. "Rapid screening of proteolytic enzymes and their inhibitors using fluorescence methods." Thesis, Loughborough University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394876.

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28

Haycock, John W. "Degradation of human muscle proteins by free radicals and proteolytic enzymes." Thesis, University of Newcastle upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260052.

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29

Poliukh, К. "Modern state in the research and application of proteolytic enzymes of fungi." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50640.

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1. Braga-Silva L.A., Santos A.L. Aspartic protease inhibitors as potential anti-Candida albicans drugs: impacts on fungal biology, virulence and pathogenesis. Curr Med Chem. 2011. Vol.18 (16). P. 2401-19. 2. Ghosh A.K., Osswald H.L., Prato G. Recent Progress in the developent of HIV-1 protease inhibitors for the treatment of HIV/AIDS. Journal of medicinal chemistry. 2016. Vol. 59 (11). P. 5172–5208. 3. Kim S.Y., Gunasekaran S., Olson N.F. Combined use of chymosin and protease from Cryphonectria parasitica for control of meltability and firmness of cheddar cheese. J Dairy Sci. 2004. Vol. 87(2

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30

Boräng, Jennifer, and Adam Boucher. "Green tea inhibits proteolytic enzymes in GCF from patients with chronic periodontitis." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19944.

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Kronisk parodontit orsakar vävnadsdestruktion till följd av matrixmetalloproteinasaktivitet. Dessa enzym härrör från värdcellerna och är en del av det immunologiska svaret på bakteriella virulensfaktorer. Grönt te har studerats för sina hälsofrämjande egenskaper, som omfattar bland annat anti-inflammatoriska effekter. Effekten beror delvis på enzyminhibering av tepolyfenoler. Syftet med denna studie var att ytterligare undersöka den inhiberande effekten av grönt te, med fokus på enzymatisk aktivitet i gingivalvätska från patienter med parodontal sjukdom. Patienter med kronisk parodontit valdes

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31

Shakery, Javad. "The isolation and characterisation of antibiotics and exo-enzymes from strains of Trichoderma harzianum." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366021.

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32

Baska, Kathleen M. "Ubiquitin-proteaseome : pathway in bovine epididymal sperm maturation /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1426044.

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33

Krause, Jason. "Purification and partial characterisation of cathepsin D from ostrich skeletal muscle, and its activity during meat maturation." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1461.

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Cathepsin D, a muscle proteinase, participates in lysosomally mediated protein degradation in vivo. This enzyme has been proposed to play a significant role in the postmortem proteolysis process apparently associated with tenderisation. The lack of data on the postmortem characteristics of ostrich meat, especially on the ageing process and its influence on meat tenderness, called for an investigation into this process. There is no data available for purified ostrich cathepsin D, and the aim of this study was, therefore, to isolate, purify and characterise cathepsin D from ostrich skeletal musc

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34

Tshidino, Shonisani Cathphonia. "Purification and partial characterization of a Myofibril-Bound Serine Protease and its endogenous inhibitor from skeletal muscle of the ostrich." Thesis, Nelson Mandela Metropolitan University, 2008. http://hdl.handle.net/10948/703.

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The ostrich is becoming an important source of meat for humans in developed and developing countries. This study was conducted to purify and characterize myofibrilbound serine protease (MBSP) and its endogenous inhibitor (MBSPI) from skeletal muscle of the ostrich. It is well documented that MBSP is tightly bound to myofibrils and its endogenous inhibitor has been purified from the same tissue of other studied mammalian species. Literature supports an association of MBSP and its endogenous inhibitor with the degradation of myofribrillar proteins, resulting in the softening of muscle that lead

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35

Thomas, Adele René. "Purification and characterisation of 20S proteasome from ostrich skeletal muscle and its role in meat tenderisation." Thesis, University of Port Elizabeth, 2004. http://hdl.handle.net/10948/320.

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The proteasome is renowned for its high molecular weight, multisubunit and mulicatalytic nature. One of its many suggested roles is the degradation of myofibrillar proteins, and therefore it has been proposed to play a role in the meat tenderisation process. The aim of this study was therefore to isolate, purify and characterise the 20S proteasome from ostrich skeletal muscle, with a view to ultimately investigating its role in the tenderisation process of ostrich meat. The 20S proteasome was successfully isolated and purified from ostrich skeletal muscle using Toyopearl Super Q-650S, Sephacry

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36

Abuelyaman, Ahmed Salih. "Synthesis and evaluation of fluorescent and biotinylated derivatives of diphenyl peptidylphosphonate esters and biotinylated isocoumarins as inhibitors of serine proteases." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/27556.

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37

Hewin, David Fitzgerald. "An investigation of the plasminogen activator system in human oesophageal and gastric carcinoma." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326095.

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38

Lu, Stephen Hsueh-Jeng. "The molecular interactions and mechanisms of intramembrane-cleaving aspartyl proteases." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610144.

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39

Hassanein, Mohamed. "Biochemical and functional characterization of a novel placental protease, cathepsin P, in rat trophoblasts." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 148 p, 2007. http://proquest.umi.com/pqdweb?did=1654487491&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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40

Vrhovski, Bernadette. "Recombinant human tropoelastin : production, properties and interactions." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27631.

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41

Molawa, Letshego Gloria. "SphereZyme (TM) technology for enhanced enzyme immobilisation application in biosensors." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1004048.

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Self-immobilisation enzyme technologies, such as SphereZyme™, suffer from the lack of applicability to hydrolyse large substrates. Solid support immobilisation is usually a method of choice, to produce a stable biocatalyst for large substrates hydrolysis in the industry. In order to investigate this limitation, a commercial protease called Alcalase® was chosen as a model enzyme due to its natural activity (hydrolysis of large substrates-proteins). Prior to immobilising through the SphereZyme™ technology, Alcalase® was partially purified through dialysis followed by CM Sepharose™ FF cation exch

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42

Bokrová, Jitka. "Příprava enkapsulovaných enzymů pro využití v kosmetice." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2014. http://www.nusl.cz/ntk/nusl-217068.

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Presented diploma thesis is focused on testing of an appropriate form of encapsulated enzymes intended for application in cosmetic and pharmaceutical industry. For encapsulation, proteolytic enzymes bromelain, papain and collagenase were used. These enzymes were encapsulated into alginate and chitosan microparticles prepared by an encapsulator and packed into liposomes. Encapsulation effectiveness was evaluated by analysis of total proteins. Particles stability was evaluated in model and real conditions by photometrical analysis of released proteins. Proteolytic activity of released enzymes in

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43

Hultmann, Lisbeth. "Endogenous proteolytic enzymes - Studies of their impact on fish muscle proteins and texture." Doctoral thesis, Norwegian University of Science and Technology, Department of Biotechnology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-178.

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<p>This thesis covers studies on endogenous proteolytic enzymes and their impact on fish muscle proteins and texture. The studies have been performed using Atlantic salmon (<i>Salmo salar</i>) and cod (<i>Gadus morhua</i>) subjected to different treatments and storage conditions.</p><p>The textural properties were very different in the two species. Salmon fillets were significantly softer and less resilient than cod fillets, and the properties changed somewhat differently during storage experiments. Different proteolytic enzymes have been reported to participate in muscle softening. Some of th

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44

Anderson, Paulette S. (Paulette Sue) 1952. "Exoprotease Production by Aeromonas hydrophila in a Chemically Defined Medium." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc504602/.

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Wretlind, Heden, and Wadstrom found ammonium sulfate to be inhibitory for the formation of extracellular protease in Aeromonas hydrophila grown in Brain Heart Infusion medium. They demonstrated by manipulating the iron and zinc content within their medium that it is possible to differentially affect the accumulation of hemolysin and protease by A. hydrophila grown in batch culture. Further manipulation of the composition of this medium was done in the present study to determine the effect of other components on the production of protease. The purpose of this study was to determine the factors

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45

Tong, Raymond Cheuk Wa. "Topological analysis of the transhydrogenase in Escherichia coli membranes using proteolytic probes." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30401.

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Using proteolytic probes, the pyridine nucleotide transhydrogenase (EC 1.6.1.1) from Escherichia coli was analyzed for its native topography in the cytoplasmic membrane. Before analyses could be performed, the isolation of transhydrogenase-enriched ISO (inside-out) cytoplasmic membrane vesicles was accomplished by modification of the procedure followed by Clarke (Clarke, D. M. and Bragg, P. D. (1985) Eur. J. Biochem. 149, 517-523) in purifying the enzyme from overexpressing E.coli JM83pDC21 cells. Two major changes were made. One was that the solubilization of the bacterial membrane and subseq

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46

Wang, Hsin Jayaswal Radheshyam K. Wilkinson Brian J. "Molecular analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity." Normal, Ill. Illinois State University, 1991. http://wwwlib.umi.com/cr/ilstu/fullcit?p9219089.

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Thesis (Ph. D.)--Illinois State University, 1991.<br>Title from title page screen, viewed January 5, 2006. Dissertation Committee: Radheshyam K. Jayaswal, Brian J. Wilkinson (co-chairs), Herman E. Brockman, Anthony J. Otsuka, Hou Tak Cheung. Includes bibliographical references (leaves 117-129) and abstract. Also available in print.

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47

Arteaga, Mac Kinney Guillermo Eleazar. "Protection of the proteolytic activity of crude papain and chemical modification of papain by tetrathionate." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27792.

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In the first chapter, sodium tetrathionate (TT), a sulfhydryl blocking agent, is assessed for its ability to protect the proteolytic activity (PA) of papaya latex during air, sun or vacuum drying, and of crude papain during storage. By means of Taguchi's L₂₇ (3¹³) fractional factorial design, it was found that the addition of 1% TT significantly increased the retention of PA of papaya latex when it was air dried at a temperature of 55°C. This protection of PA was found to be 23% higher than the one given by the addition of 1% sodium metabisulfite, the compound commonly used in the commercial

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48

Boehringer, Jonas. "Substrate recognition by the proteasome." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669968.

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The ubiquitin proteasome system targets proteins to the proteasome where they are degraded. Substrate recognition and processing prior to degradation take place at the 19S regulatory particle of the proteasome. A polyubiquitin chain, linked through isopeptide bonds formed between the C-terminal G76 and K48, is the signal responsible for delivery to the proteasome. Because chains linked via any of the seven lysine residues of ubiquitin exist in vivo and encode signals unrelated to protein degradation it is crucial for cells to avoid crosstalk between these different pathways. Several ubiquitin

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49

Dennison, Kelly J. "Development of a structural model of human T-cell leukemia virus type-I protease." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/30060.

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50

Campbell, Alyson Ann. "Affinity precipitation of proteases." Thesis, Heriot-Watt University, 1996. http://hdl.handle.net/10399/721.

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