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Relevant bibliographies by topics / Proteomics research / Dissertations / Theses

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Dissertations / Theses on the topic 'Proteomics research'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

Eriksson, Cecilia. "Affinity based proteomics research tools /." Stockholm : Skolan för bioteknologi, Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11184.

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2

Falk, Ronny. "Systems enabling antibody-mediated proteomics research." Doctoral thesis, Stockholm, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4025.

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3

Hoffman, Melissa. "Quantitative Proteomics to Support Translational Cancer Research." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7303.

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Altered signaling pathways, which are mediated by post-translational modifications and changes in protein expression levels, are key regulators of cancer initiation, progression, and therapeutic escape. Many aspects of cancer progression, including early carcinogenesis and immediate response to drug treatment, are beyond the scope of genetic profiling and non-invasive monitoring techniques. Global protein profiling of cancer cell line models, tumor tissues, and biofluids (e.g. serum or urine) using mass spectrometry-based proteomics produces novel biological insights, which support improved pa

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4

Gibson, Frank. "The development of standards for proteomics research and a proteomics investigation of diabetic adipocyte models." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445541.

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5

Larsson, Karin. "Generation and characterization of antibodies for proteomics research." Doctoral thesis, Stockholm : Skolan för bioteknologi, Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11425.

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6

Pujari, Goutam. "Current and future trends in proteomics (SELDI-TOF) in clinical diagnosis and clinical research." Thesis, Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972111.

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7

Muir, Matthew Stewart. "Proteomics of the ovine cataract." Diss., Lincoln University, 2008. http://hdl.handle.net/10182/792.

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The lens of the eye needs to be completely transparent in order to allow all light entering the eye to reach the retina. This transparency is maintained by the highly ordered structure of the lens proteins the crystallins. Any disruption to the lens proteins can cause an opacity to develop which is known as cataract. During cortical cataract formation there is increased truncation of the lens crystallins. It is believed that overactivation of calcium-dependent cysteine proteases, the calpains, is responsible for the increased proteolysis of the crystallins seen during cataractogenesis. Within

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8

Spicka, Kevin James. "Design and synthesis of fluorescent dyes for use in proteomic research." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/spicka/SpickaK0808.pdf.

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Proteomics is a rapidly developing field requiring powerful new technology in order to be able to detect proteins at increasingly lower concentrations. To aid in the detection of proteins at lower concentrations, DIGE dyes, a family of spectrally resolved fluorescent dyes, are currently available to proteomic researchers for 2D gel analysis. However, the demands of protein detection dictate that dyes that are even more sensitive and versatile be created. The syntheses of highly sensitive, water soluble BODIPY fluorophore dyes are described. These dyes are proposed to have the necessary sensiti

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9

Balluff, Benjamin. "MALDI imaging mass spectrometry in clinical proteomics research of gastric cancer tissues." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155986.

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10

Zhang, Songya [Verfasser], Andreas [Akademischer Betreuer] Bechthold, and Irmgard [Akademischer Betreuer] Merfort. "Genomics, proteomics and secondary metabolites biosynthesis research on Streptomyces asterosporus DSM 41452." Freiburg : Universität, 2018. http://d-nb.info/115950511X/34.

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11

Pueblo, Hanna Elizabeth. "APPLICATIONS OF DYNAMIC ISOELECTRIC/ANISOTROPY BINDING LIGAND ASSAY FOR PROTEOMIC RESEARCH." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/494.

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The work presented in this dissertation centers around the development of analytical tools for the study of advanced proteomics. Section 1 of this work reviews the need for high efficiency protein separation techniques. Dynamic isoelectric focusing (DIEF) is new technique similar to capillary isoelectric focusing (CIEF) invented by Dr. Luke Tolley at Southern Illinois University Carbondale. Using DIEF, the electric field inside the separation capillary can be modified using high voltage electrodes, additional to the anode and cathode, to control the depth and shape of the resulting pH gradi

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12

Williams, Taufika Ialam. "Methods development in biological mass spectrometry applications in small molecule research and proteomics /." Lexington, Ky. : [University of Kentucky Libraries], 2005. http://lib.uky.edu/ETD/ukychem2005d00368/tiwdis.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2005.<br>Title from document title page (viewed on January 19, 2006). Document formatted into pages; contains: xiv, 247 p. :ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 224-244).

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13

Williams, Taufika Islam. "METHODS DEVELOPMENT IN BIOLOGICAL MASS SPECTROMETRY: APPLICATIONS IN SMALL MOLECULE RESEARCH AND PROTEOMICS." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/288.

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Technological developments have enabled mass spectrometry (MS) to evolve asone of the most versatile, sensitive and widely used analytical methods. Key areas ofresearch in biological MS include the development of analyte-selective MSmethodologies, along with the design of MS compatible separation technology. Analytesof interest range from small, biologically active molecules in disease progressionresearch, to macromolecules such as proteins, in proteomics investigations. Advances inthese areas are vital to maintaining the level of sophistication that has become thebenchmark for MS analyses.Mas

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14

Bateson, Hannah. "Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques : development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5712.

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Introduction: Cellular membrane proteins, such as the cytochrome P450 enzyme superfamily (P450), have important roles in the physiology of the cell. P450s are important in metabolising endogenous molecules, as well as metabolising xenobiotic substances for detoxification and excretion. P450s are also implicated in cancer as they can act to 'negatively' de-activate or 'positively' activate cancer therapeutics. Identifying specific P450s that are highly up-regulated at the tumour site could be used to predict drug response and formulate targeted cancer therapy to help diminish systemic side-effe

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15

Amelina, Hanna. "Proteomics in biomarker research : Insights into the effects of aging and environment on biological systems." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56483.

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Proteomics is the global analysis of proteins that covers a broad range of technologies aimed at determining the identity and quantity of proteins expressed in the cell, their three-dimensional structure and interaction partners. In contrast to genome, proteome reflects more accurately on the dynamic state of the cell, tissue, or an organism. Therefore much is expected from proteomics to yield better disease markers for early diagnosis and therapy monitoring, as well as biomarkers that would indicate environmental exposure or provide prediction of biological age. In this thesis, I have develop

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16

Zhou, Cong. "Machine Learning Based Protein Identitification and Partial Granger Causality : Novel Bioinformatics Approaches for Proteomics Research." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505888.

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17

Potier, David N. "The development of mass spectrometry based approaches to monitor protease activity in biological fluids." Thesis, University of Manchester, 2012. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:185527.

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When treating patients with cancer, the ability to predict a patient’s response to treatment is an important tool to allow therapy to be tailored for best outcome. Therefore, the need exists for a test to forecast a patient’s response using a sample that is readily accessible, and provides an accurate reflection of a patient’s response to a disease or treatment. Profiling biological fluids, such as plasma or urine, has gained considerable interest in recent years. This is because these fluids are readily available and are expected to provide an accurate representation of a patient’s response t

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18

Balluff, Benjamin [Verfasser], and Horst [Akademischer Betreuer] Zitzelsberger. "MALDI imaging mass spectrometry in clinical proteomics research of gastric cancer tissues / Benjamin Balluff. Betreuer: Horst Zitzelsberger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/103375210X/34.

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19

Wang, Linan. "Proteomic Based Approaches for Differentiating Tumor Subtypes." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1482248318956052.

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20

Abbaoui, Besma. "BROCCOLI ISOTHIOCYANATES AS CHEMOPREVENTIVE AGENTS AND EPIGENETIC MODULATORS OF BLADDER CANCER." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1312835540.

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21

Hagerty, James Robert. "Developmental Regulation of Translation in Parasitic Flatworms." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1623424469091568.

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22

Speirs, Monique Merilyn. "Development and Use of Lipidomics and Proteomics Methods to Identify and Measure Pro-Survival Metabolic Pathways in Cancer." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7601.

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Throughout society’s continual war against cancer, we have attempted pharmacological intervention only to find that tumors develop modes of resistance. It is well known that genetics play an integral role in cancer. Technological advances have greatly improved our ability to study cancer biochemistry beyond the genome by measuring changes in the expression and activity of RNA, proteins, and lipids in experimental models and human patients. As our techniques and technology to perform cancer research progresses, it is becoming more evident that cancer cells develop stress tolerance mechanisms at

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23

Maltman, Daniel James. "Characterization of endoplasmic reticulum from castor bean and the cloning of a plant phosphatase : a basis for comprehensive plant organelle proteomics research." Thesis, Durham University, 2000. http://etheses.dur.ac.uk/4958/.

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The plant endoplasmic reticulum is the location of storage oil and membrane lipid assembly, and for fatty acid modifying reactions (desaturation, elongation, hydroxylation). It therefore represents a source of enzymes involved in these processes. Many of these defy traditional purification strategies. In this study, ER membranes have been isolated biochemically pure and in milligram quanties from the endosperm of developing and germinating castor bean. One-dimensional SDS- PAGE, used to routinely assess sample integrity, showed resolution limitations. Two-dimensional gel electrophoresis was op

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24

Harshman, Sean William. "Characterization of Histone H1 and Extracellular Vesicles by Mass Spectrometry." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385544818.

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25

Swensen, Adam Clayton. "Investigation of Dynamic Biological Systems Using Direct Injection and Liquid Chromatography Mass Spectrometry." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6574.

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In biological systems, small changes can have significant impacts. It is, therefore, very important to be able to identify these changes in order to understand what is occurring in the organism. In many cases, this is not an easy task. Mass spectrometry has proven to be a very useful tool in elucidating biological changes even at a very small scale. Several different mass spectrometry based techniques have been developed to discover and investigate complex biological changes. Some of these techniques, such as proteomics, have been through years of development and have advanced to the point tha

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26

Nibbe, Rod K. "Systems Biology of Human Colorectal Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1264179836.

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27

Komar, Hannah Marie Komar. "Identifying pathogenic stromal and acinar signaling for improved diagnosis and treatment of chronic pancreatitis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1509529255511222.

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28

Wagner, Gregory Randall. "Identification and characterization of altered mitochondrial protein acetylation in Friedreich's ataxia cardiomyopathy." Thesis, Hindawi Publishing Corporation and Oxford Journals and SAGE Journals, 2011. http://hdl.handle.net/1805/4209.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Friedreich’s Ataxia (FRDA) is a rare and poorly understood autosomal recessive disease caused by a pathological deficiency of the mitochondrial protein frataxin. Patients suffer neurodegeneration, ataxia, diabetes, and heart failure. In an effort to understand the mechanisms of heart failure in FRDA, we investigated the role of the protein modification acetylation, which is highly abundant on mitochondrial proteins and has been implicated in regulating intermediary metabolism. Using mouse models of FRDA, we found that cardiac frataxi

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29

Leary, Dagmar Hajkova. "CIRCADIAN PROTEOME CHANGES IN PHOTORECEPTOR OUTER SEGMENTS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1264276011.

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30

Daubenspeck, April Arnold. "Proteomic Analysis of Ischemic Stroke Blood Biomarkers." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1515748115902114.

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31

Head, Talia B. "Proteomic Analysis of the Crustacean Molting Gland (Y-Organ) Over the Course of the Molt Cycle." DigitalCommons@CalPoly, 2017. https://digitalcommons.calpoly.edu/theses/1830.

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Molting in crustaceans is a highly complex physiological process involving negative regulation by two paired endocrine glands, the X-organ/sinus gland complex (XO/SG) and the Y-organ (YO). The XO/SG complex is responsible for making molt-inhibiting hormone (MIH) which negatively regulates synthesis of the molting hormones, ecdysteroids, by the YO. Analysis of gene expression in the XOs and YOs has led to the development of a proposed molecular signaling pathway which regulates ecdysteroidogenesis and subsequent molting in crustaceans. In this study, changes in protein abundance in the YO were

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32

Michaels, Todd Richard. "Advancements in hardware design for proteomic research /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1456289281&sid=12&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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33

Hoover, Michael. "Proteomic Characterization of Linker Histone Variants in Breast Cancer." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1497604765734645.

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34

Cho, Chi Shing. "Proteomic and medicinal approaches to diabetes and its complications." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/663.

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35

Hitron, John Andrew. "AN OPTIMIZED SOLID-PHASE REDUCTION AND CAPTURE STRATEGY FOR THE STUDY OF REVERSIBLY-OXIDIZED CYSTEINES AND ITS APPLICATION TO METAL TOXICITY." UKnowledge, 2018. https://uknowledge.uky.edu/toxicology_etds/22.

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The reversible oxidation of cysteine by reactive oxygen species (ROS) is both a mechanism for cellular protein signaling as well as a cause of cellular injury and death through the generation of oxidative stress. The study of cysteine oxidation is complicated by the methodology currently available to isolate and enrich oxidized-cysteine containing proteins. We sought to simplify this process by reducing the time needed to process samples and reducing sample loss and contamination risk. We accomplished this by eliminating precipitation steps needed for the protocol by (a) introducing an in-solu

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36

Bigi, Mila <1985&gt. "Genomic and proteomic approaches in pig meat quality research field." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6606/.

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Pig meat and carcass quality is a complex concept determined by environmental and genetic factors concurring to the phenotypic variation in qualitative characteristics of meat (fat content, tenderness, juiciness, flavor,etc). This thesis shows the results of different investigations to study and to analyze pig meat and carcass quality focusing mainly on genomic; moreover proteomic approach has been also used. The aim was to analyze data from association studies between genes considered as candidate and meat and carcass quality in different pig breeds. The approach was used to detect new SNP

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37

Jones, Andrew. "The development of data standards and a database to aid proteomic research." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418904.

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38

Mu, Huawei. "Mechanisms of species invasion in apple snails: proteome of the egg perivitelline fluid, and proteomic responses of the adults to abiotic stressors." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/329.

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The Pomacea apple snails are amphibious operculate freshwater gastropods. They exhibit different stress tolerant abilities as some of them are invasive (e.g., Pomacea maculata and Pomacea canaliculata) and others are non-invasive species (e.g., Pomacea diffusa). By using a comparative approach, I have profiled the perivitelline fluid of P. maculata, compared the physiological and proteomic responses of P. canaliculata and P. diffusa to thermal and hypoxic stressors, and examined their sequence divergences. 74 proteins were identified from the PVF of P. maculata. Comparison of gene expression l

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39

Basu, Amrita. "Spatial Learning and Memory, Transcriptional and Proteomic Analysis of Growth Hormone Action in the Brain of bGH and GHA Mice." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1440073471.

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40

Rivera, Reyes Reginaldo [Verfasser], Andreas [Akademischer Betreuer] Kispert, Thomas [Akademischer Betreuer] Thum, and Ina [Akademischer Betreuer] Gruh. "Two complementary proteomic analyses uncover new regulators of TBX18 transcriptional function / Reginaldo Rivera Reyes ; Akademische Betreuer: Andreas Kispert, Thomas Thum, Ina Gruh ; Hannover Biomedical Research School, Institut für Molekularbiologie." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2020. http://d-nb.info/1212872134/34.

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41

Martín, Pérez Miguel. "Physiological changes in the muscle of gilthead sea bream induced by culture and feeding conditions: a stable isotopes (15(N) and 13(C)) and proteomic study Cambios fisiológicos en el músculo de dorada inducidos por las condiciones de cultivo y alimentación: Estudio con isótopos estables (15(N) y 13(C)) y proteómica." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/104148.

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Stable isotopes, as tracers of the food chain, have been used to characterize the relationship between consumers and their food since isotopic fractionation implies discrimination against certain isotopes. But stable isotope analyses (SIA) can also be carried out in fish reared with artificial diets, as gilthead sea bream (Sparus aurata), the species most cultivated in the Mediterranean. Changes in natural abundance of stable isotopes (13C and 15N) in tissues and its reserves may reflect changes in the use and turnover of nutrients as the catabolic enzymes involved in the processes of decarbox

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42

You-Chia, Yeh, and 葉又嘉. "The Proteomics Research of Colorectal Cancer." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/22341619152128110348.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>91<br>In attempt to have better understanding of possible mechanism causing colon cancer and identify disease-specific proteins for early screening, we adopted 2-D electrophoresis in conjunction with Mass spectrum techniques to approach this issue. We focused the research mainly on the characterization of different spot patterns between normal and cancerous tissue from patients with colon cancer in Taiwan. The results obtained from analyzing cancerous tissues of colon indicates that six proteins with increased expression level are Hsp60, S100A1

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43

Atkinson, Kelly Rene LeFevre. "Proteomic biomarker discovery for preeclampsia." 2008. http://hdl.handle.net/2292/2565.

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Preeclampsia is a serious multisystem complication of late pregnancy with adverse effects for mothers and babies. Currently this disorder is diagnosed from clinical observations occurring late in the disease process. Unknown factors in the maternal circulation, possibly released by the preeclamptic placenta, have been linked to the pathophysiological changes characteristic of the disorder. The research in this thesis used proteomic techniques to identify putative preeclampsia biomarkers from two sources: secreted from a placental cell line undergoing differentiation, and directly sampled fr

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44

Sahab, Ziad Joseph Sang Qing-Xiang Amy. "Batch anion exchange separation a prefractionation technique for proteome research and its applications on in vivo cancer samples /." Diss., 2005. http://etd.lib.fsu.edu/theses/available/etd-11102005-151301.

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Thesis (Ph. D.)--Florida State University, 2005.<br>Advisor: Qing-Xiang A. Sang, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed May 11, 2006). Document formatted into pages; contains xvii, 118 pages. Includes bibliographical references.

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45

Alakhras, Nada S. "A method to isolate the CTD of RNA Polymerase II for proteomics analysis." Thesis, 2014. http://hdl.handle.net/1805/6179.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>In an effort to advance the methodology in analyzing RNAPII protein-protein interaction network and to determine the role of the CTD in controlling RNAPII transcription, we devised a method to specifically isolate the CTD-associated and CTD-less RNAPII to identify the proteins that interact with both the CTD and the globular core of RNAPII using novel purification scheme coupled to quantitative proteomics.

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46

(5930141), Minervo Perez. "HIGH-THROUGHPUT IDENTIFICATION OF ONCOGENIC TYROSINE KINASE SUBSTRATE PREFERENCES TO IMPROVE METHODS OF DETECTION." Thesis, 2021.

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<div>The use of computational approaches to understand kinase substrate preference has been a powerful tool in the search to develop artificial peptide probes to monitor kinase activity, however, most of these efforts focus on a small portion of the human kinome. The use of high throughput techniques to identify known kinase substrates plays an important role in development of sensitive protein kinase activity assays.</div><div>The KINATEST-ID pipeline is an example of a computational tool that uses known kinase substrate sequence information to identify kinase substrate preference. This appro

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Tsai, Chou-Huang, and 蔡宙晃. "Studies of antilithic effects of Wulingsan on calcium oxalate stones – an experimental induced-nephrocalcinosis rat model and proteomics research." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/94010800970695926609.

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博士<br>中國醫藥大學<br>中國醫學研究所博士班<br>97<br>Urolithiasis is a common disease in Taiwan, and the medical expenditure is quite huge. The purposes of this study are to explore the mechanism of nephrocalcinosis using molecular technologies and to evaluate the antilithic abilities of a Traditional Chinese herbal formula, Wulingsan (WLS), by an ethylene glycol-induced nephrocalcinosis rat model. Forty one male Sprague-Dawley rats were divided into four groups. Eight rats were fed with normal chaw and water servered as the normal control, and the others received 0.75% ethylene glycol-added water as a stone i

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48

Djukic, Michael. "Proteomic investigations and biomarker discovery in transient ischaemic attack." Thesis, 2017. http://hdl.handle.net/2440/112817.

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Between 15-26% of ischaemic strokes are preceded by transient ischaemic attack (TIA) making accurate and timely diagnosis of TIA important for stroke prevention. However, TIA diagnoses are highly reliant on subjective history gathering and clinical assessments to differentially diagnose true TIA conditions from mimic presentations. Unfortunately, the subjective nature of TIA diagnosis has created a surprisingly high amount of variability between diagnoses made by physicians and specialist neurologists. Use of biomarker tests could offer an objective quantitative measuring tool that reduces int

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49

Chiu, Hui-Wen, and 邱惠雯. "1. The Antioxidant Effect of Caffeic Acid Phenethyl Ester on Human Neutrophils 2.The Proteomics Research on Neutrophil, Platelet and Vascular Smooth Muscle Cell." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/94276412368949891215.

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碩士<br>長庚大學<br>天然藥物研究所<br>92<br>1.The neutrophil is body’s first line of defense against microorganisms and a critical effector cell in both innate and humoral immunity. However, the capacity for bacterial killing carriers with it an implicity for host tissue destruction, as observed in inflammatory and autoimmune disease. Neutrophils produce potentially dangerous metabolites from superoxide in the defense against microorganisms. Alternatively, caffeic acid phenethyl ester (CAPE) was isolated from propolis that has many biological and pharmacological activities including anti-oxidation and anti

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Wei, Wei. "Microfluidics-Based Single-Cell Functional Proteomics Microchip for Portraying Protein Signal Transduction Networks within the Framework of Physicochemical Principles, with Applications in Fundamental and Translational Cancer Research." Thesis, 2014. https://thesis.library.caltech.edu/8112/1/Wei_Wei_2014_thesis.pdf.

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<p>Single-cell functional proteomics assays can connect genomic information to biological function through quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years and are providing unique opportunities. This thesis describes an emerging microfluidics-based toolkit for single cell functional proteomics, focusing on the development of the single cell barcode chips (SCBCs) with applications in fundamental and translational cancer research.</p> <p>The microchip designed to simultaneously quantify a panel of secreted, cytopl

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