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1

Hartley, James L., ed. Protein Expression in Mammalian Cells. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-352-3.

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2

Hacker, David L., ed. Recombinant Protein Expression in Mammalian Cells. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8730-6.

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3

Hauser, Hansjörg, and Roland Wagner, eds. Mammalian Cell Biotechnology in Protein Production. DE GRUYTER, 1997. http://dx.doi.org/10.1515/9783110809282.

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4

Ho, Sylvia. Chaperone-assisted protein disaggregation in the mammalian system. National Library of Canada, 2003.

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5

Protein expression in mammalian cells: Methods and protocols. Humana Press, 2012.

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6

Grand, Roger John Alfred. The relationship of protein structure to function: Studies on mammalian and viral regulatory polypeptides. University of Birmingham, 1986.

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7

Kim, Sandra Ann. Attempts to express the regulatory domain of protein kinase C-alpha in mammalian cell lines. National Library of Canada = Bibliothèque nationale du Canada, 1999.

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8

1959-, Gabai Vladimir L., ed. Heat shock proteins and cytoprotection: ATP-deprived mammalian cells. R.G.Landes, 1996.

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9

Kabakov, Alexander E. Heat shock proteins and cytoprotection: ATP-deprived mammalian cells. Springer, 1997.

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10

(Editor), Hansjorg Hauser, and Roland Wagner (Editor), eds. Mammalian Cell Biotechnology in Protein Production. Walter de Gruyter, 1997.

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11

Wagner, Roland, and Hansj Hauser. Mammalian Cell Biotechnology in Protein Production. De Gruyter, Inc., 1997.

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12

Castro, Fidel O. Mammary Gland Transgenesis: Therapeutic Protein Production. Springer, 2013.

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13

1961-, Castro Fidel O., and Jänne Juhani, eds. Mammary gland transgenesis: Therapeutic protein production. Springer, 1998.

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14

Alfred, Doig, ed. Protein therapeutics production : large-scale mammalian cell culture. DMD Publications, 2005.

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15

(Editor), Fidel O. Castro, and Juhani Jänne (Editor), eds. Mammary Gland Transgenesis: Therapeutic Protein Production (Biotechnology Intelligence Unit). Springer, 1998.

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16

Mikhailov, Alexei. Practical Fluorescence Microscopy in Mammalian Cells: Protein Localization and Function. Humana Press, 2008.

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17

1949-, Hauser Hansjörg, and Wagner Roland 1956-, eds. Mammalian cell biotechnology in protein production /editors, Hansjörg Hauser, Roland Wagner. Walter de Gruyter, 1997.

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18

Peptides in Mammalian Protein Metabolism: Tissue Utilisation & Clinical Targetting (Portland Press Proceedings,). Ashgate Publishing, 1997.

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19

Roe, Simon, ed. Protein Purification Techniques. Oxford University Press, 2001. http://dx.doi.org/10.1093/oso/9780199636747.001.0001.

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Proteins are an integral part of molecular and cellular structure and function and are probably the most purified type of biological molecule. In order to elucidate the structure and function of any protein it is first necessary to purify it. Protein purification techniques have evolved over the past ten years with improvements in equipment control, automation, and separation materials, and the introduction of new techniques such as affinity membranes and expanded beds. These developments have reduced the workload involved in protein purification, but there is still a need to consider how unit
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20

St-Pierre, Benoit. Stra 13: An E-box repressor protein expressed in mammary epithelial cells. 2002.

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21

Fleming, Scott William. Characterizaton of an LSD-induced inhibitor of protein synthesis in the mammalian brain. 1986.

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22

Bascom, Roger Andrew. Identification, molecular and genetic characterization of a novel mammalian photoreceptor membrane protein (ROM1). 1994.

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23

Joshi, Purna A. Alx4, a stromally-restricted homeodomain protein, is required for normal mammary epithelial morphogenesis. 2006.

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24

Batt, Jane. Characterization of the role of protein tyrosine phosphatase sigma (PTP[sigma]) in mammalian development. 2002.

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25

Hope, James, and Mark P. Dagleish. Prion-protein-related diseases of animals and man. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0041.

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Scrapie, bovine spongiform encephalopathy (BSE), Creutzfeldt–Jakob disease (CJD), and related diseases of mink (transmissible mink encephalopathy), mule deer and elk (chronic wasting disease) are the founder members of a group of diseases called the transmissible degenerative (or spongiform) encephalopathies (TSE). These diseases can be transmitted by prions from affected to healthy animals by inoculation or by feeding diseased tissues. Prions are cellular proteins that can transfer metabolic and pathological phenotypes vertically from parent to progeny or horizontally between cells and animal
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26

Clark, Bruce Douglas. Characterization of a heat shock protein synthesized in the mammalian retina following LSD-induced hyperthermia. 1987.

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27

Sabatinos, Sarah Anne. Investigation of the function of UV damaged DNA binding protein 1 (DDB1) in mammalian systems. 2005.

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28

Bagni, Claudia, and Eric Klann. Molecular Functions of the Mammalian Fragile X Mental Retardation Protein: Insights Into Mental Retardation and Synaptic Plasticity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199744312.003.0008.

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Chapter 8 discusses how Fragile X syndrome (FXS) is caused by the absence of the RNA-binding protein fragile X mental retardation protein (FMRP). FMRP is highly expressed in the brain and gonads, the two organs mainly affected in patients with the syndrome. Functionally, FMRP belongs to the family of RNA-binding proteins, shuttling from the nucleus to the cytoplasm, and, as shown for other RNA-binding proteins, forms large messenger ribonucleoparticles.
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29

Gabai, Vladimir L., and Alexander E. Kabakov. Heat Shock Proteins and Cytoprotection: Atp-Deprived Mammalian Cells. Springer, 2012.

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30

Uludag, Hasan. Microencapsulation of mammalian cells by an interfacial precipitation process: in vitro and in vivo cell survival and protein delivery. 1993.

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31

Gabai, Vladimir L., and Alexander E. Kabakov. Heat Shock Proteins and Cytoprotection: Atp-Deprived Mammalian Cells (Molecular Biology Intelligence Unit). Springer, 1996.

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32

Kramer, Carolyn, and Emily Blumberg. Immunosuppressants and Antiretroviral Therapy in HIV-Positive Transplant Patients. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0028.

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Protease inhibitors (PIs), especially ritonavir, are inhibitors of CYP3A4 and P-gp1 and can significantly increase levels of calcineurin inhibitors and mammalian target of rapamycin (mTOR) inhibitors. Cobicistat is an inhibitor of CYP3A4, and its effect on levels of calcineurin inhibitors and mTOR inhibitors is likely to be similar to that of ritonavir. Efavirenz may result in lower concentrations of calcineurin inhibitors and mTOR inhibitors. Dose reduction and careful attention to monitoring drug levels are critical to avoid toxicity and maintain therapeutic immunosuppressive concentrations
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33

Dixon, Bradley P., J. Christopher Kingswood, and John J. Bissler. Tuberous sclerosis complex renal disease. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0330.

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Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder affecting almost all organs. It has wider phenotypic variation than often appreciated, with less than half showing the combination of characteristic facial angiofibromas, epilepsy, and mental retardation. Renal angiomyolipomata or cysts are found in 90% and renal failure was historically a common mode of adult death from the disease. Pulmonary lymphangioleiomyomatosis is restricted to females. Angiomyolipomata or cystic disease, or both, may cause renal failure. Angiomyolipomata may also haemorrhage, especially from lar
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34

King, Carolyn M., Grant Norbury, and Andrew J. Veale. Small mustelids in New Zealand: invasion ecology in a different world. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198759805.003.0010.

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This chapter reviews the ecology of the three species of small mustelids introduced into New Zealand: the ferret (Mustela furo), the stoat (M. erminea) and the weasel (M. nivalis), for biological control of rabbits. New Zealand offers a mosaic of environments totally different from those in which the three species evolved, including a diminishing array of endemic fauna especially vulnerable to mammalian predators. Mustelids in New Zealand display significant adaptive flexibility in diet, habitat selection, co-existence, dispersal, body size, population biology and predatory impact, with result
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35

George, Grimble, and Backwell F. R. C, eds. Peptides in mammalian protein metabolism: Tissue utilization and clinical targeting : proceedings of the conference held at the Rowett Research Institute, Aberdeen, in September 1994. Portland, 1998.

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36

Glen, Alistair, and Christopher Dickman, eds. Carnivores of Australia. CSIRO Publishing, 2014. http://dx.doi.org/10.1071/9780643103177.

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The Australian continent provides a unique perspective on the evolution and ecology of carnivorous animals. In earlier ages, Australia provided the arena for a spectacular radiation of marsupial and reptilian predators. The causes of their extinctions are still the subject of debate. Since European settlement, Australia has seen the extinction of one large marsupial predator (the thylacine), another (the Tasmanian devil) is in danger of imminent extinction, and still others have suffered dramatic declines. By contrast, two recently-introduced predators, the fox and cat, have been spectacularly
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37

D, Lonsdale-Eccles J., and International Laboratory for Research on Animal Diseases., eds. Protein traffic in parasites and mammalian cells: Proceedings of a workshop held at the International Laboratory for Research on Animal Diseases, Nairobi, Kenya, 29 August to 1 September 1988. International Laboratory for Research on Animal Diseases, 1989.

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38

Bannister, John. Great Whales. CSIRO Publishing, 2008. http://dx.doi.org/10.1071/9780643096196.

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Whales are mysterious and fascinating creatures. Despite modern technology, their world is still largely unexplored and unknown. They can only be seen, or rather glimpsed, when they are near the sea surface, either from boats, or perhaps from shore, or underwater by divers. They also reach astonishing sizes – the blue whale, for example, can grow to 30 metres in length, equivalent to the height of a six-storey building, and can weigh more than 130 tonnes.
 Seven ‘Great Whales’ are found in the coastal waters surrounding Australia. These include six of the largest baleen whales – blue whal
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39

Meng, X. J. Hepatitis E virus. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0048.

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Hepatitis E virus (HEV) is a small, non-enveloped, single-strand, positive-sense RNA virus of approximately 7.2 kb in size. HEV is classified in the family Hepeviridae consisting of four recognized major genotypes that infect humans and other animals. Genotypes 1 and 2 HEV are restricted to humans and often associated with large outbreaks and epidemics in developing countries with poor sanitation conditions, whereas genotypes 3 and 4 HEV infect humans, pigs and other animal species and are responsible for sporadic cases of hepatitis E in both developing and industrialized countries. The avian
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40

Alexander, D. J., N. Phin, and M. Zuckerman. Influenza. Edited by I. H. Brown. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0037.

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Influenza is a highly infectious, acute illness which has affected humans and animals since ancient times. Influenza viruses form the Orthomyxoviridae family and are grouped into types A, B, and C on the basis of the antigenic nature of the internal nucleocapsid or the matrix protein. Infl uenza A viruses infect a large variety of animal species, including humans, pigs, horses, sea mammals, and birds, occasionally producing devastating pandemics in humans, such as in 1918 when it has been estimated that between 50–100 million deaths occurred worldwide.There are two important viral surface glyc
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