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Dissertations / Theses on the topic 'Protesi mammaria'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Nuti, Nicola. "I Biomateriali impiegati nelle applicazioni protesiche estetiche." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017.

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L'obiettivo principale di questo lavoro di tesi compilativa è stato quello di descrivere nel più ampio modo possibile tutti gli aspetti più importanti che si affrontano nella progettazione dei dispositivi in biomateriale, appartenenti al campo della protesica estetica. Questo è un settore in costante crescita, grazie all’impulso offerto dal mercato dei paesi in “via di sviluppo”, data l’affermazione della sua importanza nel contesto sociale di questi ultimi. Nel settore delle protesi estetiche, poiché l’aspetto funzionale coincide proprio con l’impatto estetico, i vincoli meccanici o di sicure

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2

Dou, Dengfeng. "Mammalian and viral protease inhibitors." Diss., Wichita State University, 2010. http://hdl.handle.net/10057/3281.

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Chronic Obstructive Pulmonary Disease (COPD) is currently the fourth leading cause of death in the US. COPD is a multi-factorial disorder characterized by an oxidant/antioxidant imbalance, inflammation, a protease/antiprotease imbalance and apoptosis. This dissertation describes a general strategy for the design, synthesis and biochemical evaluation of dual function inhibitors which could potentially interrupt the above disorder, thereby enhancing the treatment of COPD. An example of this type inhibitor based on the 1,2,5-thiadiazolidin-3-one scaffold has been proven effective against both hum

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3

BERNARD, DOMINIQUE. "Expression des antigenes hla-dr par le tissu mammaire dans les cancers du sein." Clermont-Ferrand 2, 1986. http://www.theses.fr/1986CLF2E367.

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Mise au point d'une technique permettant le masquage de l'anticorps monoclonal anti hla-dr et de l'antigene hla-dr des cellules, l'immunoprecipitation des antigenes hla-dr, l'isolement de l'immun complexe et sa quantification par chromatofocusing. Mise en evidence de la regulation hormonale de l'expression des antigenes: en particulier role de la prolactine de l'oestradiol et de la progesterone. Effets de la gestation et de la lactation. Travail effectue sur la tumeur mammaire chimio-induite par la n-nitroso-n-methyluree chez la rate ainsi que sur un modele tumoral humain: la lignee mcf7

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4

Terrone, Donato Gerardo. "Ras protein targeting in mammalian cells." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98506.

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The Ras proteins (H-Ras, N-Ras and K-Ras4B) are monomeric GTP-binding proteins that play key roles in cell regulation. It has been proposed that correct plasma membrane localization of the Ras proteins requires 'two signals', the processed farnesylation sequence and an adjacent palmitoylation site(s) or polybasic sequence. First, to investigate potential proteinaceous binding partners for the K-Ras4B targeting sequence at the plasma membrane, an in vivo crosslinking analysis was carried out. Consistent with current suggestions that K-Ras4B interacts via electrostatic interactions with plasma m

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5

Lee, Melanie. "Characterisation of the mammalian P23 protein." Thesis, St George's, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263724.

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6

Zotter, Angelika Monika. "Protein Dynamics in Mammalian Genome Maintenance." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/12292.

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7

Alnagar, Fahima Ali. "Protein phosphorylation in mammalian sperm during capacitation." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54246/.

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Subcellular fractionation revealed that pp97, pp96 and pp64 are head protein whereas pp90 and pp55 are tail proteins. Advanced proteomic analysis (GeLC-MS) identified 37 proteins, including AKAP4, AKAP3, CALI, HSPAlL and HSP70 as candidates for the dephosphorylated proteins. AKAP4 was excluded because it was localised to the tail. Two AKAP3 antibodies showed non-specific binding and a better quality antibody will be needed for further investigations. CALI was excluded because it was localised to the tail fraction. HSP70/72 and HSPA1L were strong candidates for pp64. However, immunoprecipitatio

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8

Hlaing, Daren John. "Characterisation of a novel mammalian rhomboid protease." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612873.

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9

Keen, Michael John. "Low-protein media for specialised mammalian cells." Thesis, London South Bank University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336367.

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10

Volkmar, Norbert. "The mammalian EMC in membrane protein biogenesis." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:27a4910a-fb8a-4ce7-97d6-7051c2cae9d0.

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The mammalian Endoplasmic Reticulum Membrane protein Complex (mEMC) has previously been implicated in a range of cellular activities, including the biogenesis of oligomeric plasma membrane receptors, endoplasmic reticulum (ER)-mitochondrial phospholipid transfer, and as a host factor modulating viral pathogenicity. Despite its evolutionary conservation in all eukaryotes, the biological functions and molecular mechanism of the EMC remain poorly understood. Here, the requirement of the mEMC for integral membrane protein biogenesis is investigated. It is reported that the mEMC is involved in the

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11

Hermesmeier, Jan. "Identifizierung und Charakterisierung der ersten Histidin-Protein-Phosphatase in Mammalia." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962397385.

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12

Dulic, Anna. "Studies on protein : protein interactions in mammalian DNA base-excision repair." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404820.

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13

Chrysina, Evangelia D. "Structural studies on α-lactalbumin and retinol binding protein". Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323727.

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14

Slack, Carolyn. "Molecular studies of a mammalian DNA kinase." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23938.

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Whole cell extracts from fresh calf thymus glands were subjected to Polymin P fractionation and Q Sepharose chromatography. Three peaks of DNA kinase activity, designated SNQI, SNQII and SNQIII, were found in the supernatant fraction. Studies of SNQI have revealed an estimated molecular mass of 50-90 kDa by Superose 12 chromatography, and activity gel analysis following SDS-PAGE identified an active polypeptide of approximately 55 kDa. This enzyme preparation, purified 10,000-fold, phosphorylated 5$ sp prime$-OH-terminated oligodeoxyribonucleotides and double stranded DNA, yet was inactive on

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15

Huang, Kristen Marie. "Protein glycosylation studies in mammalian cells and yeast." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1057779808.

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16

McCartney, Richard Graham. "Folding and assembly studies on the components of mammalian PDC and OGDC." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264145.

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17

Kim, Hyung Chan 1972. "Characterization of a novel mammalian cap-binding protein." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20963.

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All eukaryotic mRNAs (except organellar) are capped at their 5' end. The cap structure (m7GpppN, where N is any nucleotide) is extremely important for the processing and translation of mRNA. A modified form of this cap is also present in some snRNAs. Several cap-recognizing proteins that mediate these processes have been characterized. This thesis describes a novel human cytoplasmic protein that is 30% identical and 60% similar in sequence to the human translation initiation factor 4E (eIF4E). This protein, named 4E-Homologous Protein (4EHP), binds specifically to the cap structure. Sequence a

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18

Kim, Hyung Chan. "Characterization of a novel mammalian cap-binding protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0027/MQ50806.pdf.

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19

Wang, Yuqin. "Protein and lipid interactions of mammalian antibacterial peptides /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4698-1/.

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20

Peet, Daniel J. "Protein-bound fatty acids in mammalian hair fibres /." Connect to thesis, 1994. http://eprints.unimelb.edu.au/archive/00000641.

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21

Yin, Zhikang. "Protein turnover in serum-deprived mammalian cell cultures." Thesis, University of Aberdeen, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262175.

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The aim of this project is to test the hypothesis that the rate of turnover of newly synthesized proteins plays a major part in the regulation of cell growth. Normal and transformed cells have been used to compare their responses to serum levels. When the cells are cultured in 0.2% serum medium, increase of cell number is slower than in normal cultures. Cell volume is reduced, while cell mass may be maintained or decreased depending on the rate of protein accumulation and cell proliferation, so unbalanced growth may occur in certain circumstances. During serum deprivation, accumulation of newl

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22

Green, Andrew J. "Prokaryotic expression of mammalian G protein-coupled receptors." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336616.

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23

Klemm, Elizabeth J. (Elizabeth Joanna). "Protein quality control in the mammalian endoplasmic reticulum." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/62782.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.<br>Cataloged from PDF version of thesis. "February, 2011."<br>Includes bibliographical references.<br>Quality control is an important part of protein biogenesis. Aberrant proteins must be destroyed before they aggregate and cause deleterious effects. Failure to do so can result in cell death or malfunction and, ultimately, disease. Quality control involves the recognition of misfolded proteins and their degradation. For secretory and membrane proteins, folding occurs in the endoplasmic reticulum (ER), but degradati

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24

Blanchette, Paola. "Functional analysis of Unp, a mammalian ubiquitin protease." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6281.

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The murine Unp gene encodes a ubiquitously expressed protein that fractionates with the nuclear fraction (hence its name ubiquitous nuclear protein) (Gupta, K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., and Gray, D. A. (1993). Oncogene 8, 2307-10). It possesses proprieties of an oncogene, such as the ability to promote tumours in a nude mouse assay (Gupta, K., Chevrette, M., and Gray, D. A. (1994). Oncogene 9, 1729--31), and its human homologue, USP4 (previously known as Unph), was shown to be over expressed in certain types of human lung tumours (Gray, D. A., Inazawa, J., Gupta, K., Wo

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25

Prinos, Panagiotis. "Purification and characterization of a mammalian DNA kinase." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55524.

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Using a novel purification scheme and a new assay for detection of DNA kinase activity, a Polymin P-precipitable DNA kinase has been identified and characterized from calf thymus extracts. The DNA kinase activity was able to phosphorylate RNA as well as single-stranded and double-stranded DNA, therefore it has been termed Polymin P-precipitable polynucleotide kinase (PP-PNK). The enzyme had a neutral to alkaline, broad pH optimum that distinguished it from the previously described mammalian DNA kinases that have an acidic pH optimum. The sedimentation coefficient of the enzyme was 3.4-3.8 S, i

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26

Rius, Agustin Gregorio. "Nitrogen Efficiency and Regulation of Protein Synthesis in Lactating Dairy Cows." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/37780.

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Dairy herds are major contributors to N pollution because 70% of the N intake is lost to the environment and 30% or less is retained in milk protein. Plasma amino acids (AA) that are not used for protein synthesis in mammary glands (MG) are catabolized in post splanchnic tissues (liver plus gastrointestinal tract, pancreas, spleen, portal system, and associated adipose tissue) and two thirds of the net supply of essential AA (EAA) are cleared in splanchnic tissues. Thus, increasing AA capture in MG would be expected to reduce AA catabolism and thereby increase efficiency of AA utilization.

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27

Cox, S. "The regulation of polypeptide chain initiation in mammalian cells." Thesis, University of Kent, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377944.

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28

Kunaparaju, Raj Kumar Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Epi-CHO, an episomal expression system for recombinant protein production in CHO cells." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41499.

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The current project is to develop a transient expression system for Chinese Hamster Ovary (CHO) cells based on autonomous replication and retention of plasmid DNA. The expression system, named Epi-CHO comprises (1) a recombinant CHO-K1 cell line encoding the Polyoma (Py) virus large T-Antigen (PyLT-Ag), and (2) a DNA expression vector, pPy/EBV encoding the Py Origin (PyOri) for autonomous replication and encoding the Epstein-Barr virus (EBV), Nuclear Antigen-1 (EBNA-1) and EBV Origin of replication (OriP) for plasmid retention. The CHO-K1 cell line expressing PyLT-Ag, named CHO-T was adapted t

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29

Lane, Rebecca M. "The control of protein synthesis in stressed mammalian cells." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279818.

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30

Adam, Ilectra Stavroula. "Exploring the chaperone function of the mammalian torsinA protein." Thesis, University of Kent, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.591086.

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The molecular chaperone Hspl04, in conjunction with two other chaperones Hsp70 and Hsp40, provides the yeast Saccharomyces cerevisiae with the necessary machinery to ensure that aggregated proteins that form in stressed cells can be remodelled back to a correctly folded and functio nal form. Hspl04 also plays an essential role in non-stressed cells in the propagation of yeast prions such as [PSt1, the prion form of the translation termination factor Sup3S. To date no functional mammalian orthologues of Hspl04 have been described although TorsinA, a 37 kOa ER located protein shows some degree o

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31

Davies, Brendan. "The organisation and expression of mammalian ribosomal protein genes." Thesis, Institute of Cancer Research (University Of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292471.

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32

Ksagoni, Asimina. "Characterisation of the mammalian BAR domain-containing protein arfaptin." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609100.

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33

Edwards, Lorraine Katy. "Biochemical characterization of mammalian high mobility group protein A2." FIU Digital Commons, 2006. http://digitalcommons.fiu.edu/etd/3118.

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The high mobility group protein HMGA2 is an architectural transcription factor, which is expressed during embryogenesis. Aberrant expression causes benign and malignant tumor formation. The protein possesses three "AT hook" domains and an acidic Cterminal. HMGA2 is natively unstructured, however it forms a homodimer. In this study site-directed mutagenesis was used to create single methionine mutants, HMGA2Q37M, HMGA2I71M and HMGA2Q85M. These mutants were cross-linked using EDC and then cleaved using CNBr to determine which domains are involved in homodimer formation. Our results indicate that

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34

Granger, Paulnisha Davida. "Abundance and Localization of (Yes-associated protein) YAP in Prepubertal Bovine Mammary Tissue." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/96240.

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Most mammary development is postnatal. Mammary growth that occurs before puberty is diminutive in amount but consequential for future milk production, especially in dairy heifers. With advanced knowledge on fundamental aspects that govern prepubertal mammary development, scientists and farmers alike can ensure that heifers perform their best once they become cows. The Hippo pathway has been identified as an evolutionarily conserved pathway that regulates organ size in many animal species; it might contribute to mammary growth in dairy heifers. This pathway is mediated by yes-associated protein

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35

Mandla, Suzan (Suzan G. ). "Studies on mammalian 25-hydroxyvitamin D3-24-hydroxylase." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39363.

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This thesis describes three studies on mammalian 25-hydroxyvitamin D$ sb3$-24-hyroxylase (24-hydroxylase), the first enzyme in the C24-oxidation pathway, a major catabolic pathway for vitamin D metabolites in kidney and other target tissues for vitamin D hormone. The first study examines the involvement of protein kinase C in the regulation of 24-hydroxylase activity in mouse kidney. Evidence is presented supporting a stimulatory role for protein kinase C in the regulation of constitutive, but not inducible, renal 24-hydroxylase. The kinase is also implicated in the aberrant expression of rena

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36

Fiebitz, Andrea. "High-throughput screening of protein-protein-interactions in Mammalian Cells using transfected cell arrays." [S.l.] : [s.n.], 2007. http://www.diss.fu-berlin.de/2007/59/index.html.

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37

Ferreiro, Neira Isabel. "Transcriptional regulation by the mammalian stress-activated protein kinase p38." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/80661.

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Regulation of transcription by Stress Activated Protein Kinases (SAPKs) is an essential aspect for adaptation to extracellular stimuli. In mammals, the activation of the p38 SAPK results in the regulation of gene expression through the direct phosphorylation of several transcription factors. However, how p38 SAPK regulates the proper gene expression program of adaptation to stress as well as the basic mechanisms used by the SAPK remains uncharacterized. The results displayed in this manuscript show that the p38 SAPK plays a central role in the regulation of gene expression upon stress, as up t

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38

McKenna, Tomás. "Oxidative stress on mammalian cell cultures during recombinant protein expression." Licentiate thesis, Linköping University, Linköping University, Biotechnology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51823.

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<p>When the cell is under stress arising from oxidation, heat, infection, toxic contamination or any other stressful condition, proteins may unfold and expose residues in their structure that under normal physiological conditions are hidden and shielded from chemical reactions.</p><p>In this licentiate thesis the effects of general oxidative stress on the production of recombinant protein by mammalian cells are considered.</p><p>The work consisted of a broad literary review focused on oxidative stress and cellular response, cross-protection, gene regulation in response to oxidative stress and

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39

Wang, Zilong. "Expression of epitope-tagged protein kinase CK2 in mammalian cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ32281.pdf.

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40

Hsieh, Shu-Ju. "Structural and functional characterisation of mammalian cold shock protein CIRP." Thesis, University of Kent, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544060.

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41

Linch, M. D. "Protein kinase C iota in mammalian cell polarity and cancer." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344059/.

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Protein Kinase C iota (PKCɩ) is a serine/threonine kinase that is involved in epithelial polarity and malignancy where polarity is typically abrogated. The aim of this thesis was to characterise the role of PKCɩ in oncogenic signaling in the context of polarity loss. This work set out to identify activators, binding partners and downstream effectors of PKCɩ with a view to informing rational therapeutic design. Madin Darby Canine Kidney (MDCK) cells, grown as polarised cysts containing a central lumen in Matrigel, developed a multiple-lumen phenotype on perturbation of PKCɩ, suggesting a thresh

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42

Austin, Nicola Julie. "Localisation of ROMK protein in mammalian kidney and other tissues." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298966.

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43

Anthony, Shelagh. "Analysis of mammalian protein arginine N-methyltransferases in the vasculature." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424909.

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44

Ruiz, Arlandis Gemma. "Binding and internalization of exogenous protein assemblies by mammalian cells." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114814.

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Le mépliement et l'agrégation des protéines sont à l'origine de nombreuses maladies neurodégénératives, dont la maladie de Huntington (HD) et la maladie de Parkinson (PD). Même si l’agrégation de différentes protéines liées à des maladies est bien documentée, on en sait peu sur l'interaction entre les protéines mal repliées et les cellules neuronales, qui leur permettent de se propager et affecter différentes régions du cerveau. L'objectif de ma thèse était de générer des modèles cellulaires rapporteurs de la huntingtine et l’α-synucléine, protéines dont le mauvais repliement et l'agrégation s

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45

Petersen, Birgit Otzen. "Regulation of mammalian CDC6 by CDK phosphorylation and proteasome dependent degradation." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298212.

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46

Dadehbeigi, Nazanin. "Investigation of the role of the mTORC1 signalling pathway in growth and productivity of industrially-relevant GS-CHO cells." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-the-role-of-the-mtorc1-signalling-pathway-in-growth-and-productivity-of-industriallyrelevant-gscho-cells(b7820f57-2023-4667-830d-53ce1fe7eb76).html.

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Understanding the molecular mechanisms that govern productivity and growth of recombinant host cells is essential to devise informed approaches to increase commercial viability and availability of biopharmaceuticals. This work has focused on the roles of the mammalian target of rapamycin complex 1 (mTORC1) signalling pathway in CHO cells, the most widely used expression system in the biopharmaceutical industry. mTORC1 is a master regulator of cell growth, protein synthesis and metabolism in response to availability of nutrients, oxygen and growth factors. Therefore, it was hypothesised that in

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47

Patrício, Daniela Marques. "Implementation of mammalian two-hybrid system for highthroughput drugs screening." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22327.

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Mestrado em Biologia Molecular e Celular<br>The base of cell communication is signalling pathways which, when deregulated can lead to several diseases, from cancer to autoimmune diseases. Protein-protein interactions (PPIs) are the backbone of signalling pathways. Consequently, identifying and modulating PPIs can unravel the pathophysiological mechanisms of a disease. When considering the male reproductive system, the same is observed, hence PPIs are responsible and regulate most of the cellular functions. PPP1CC2 is a testis enriched protein, key to sperm motility acquisition. Its interaction

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48

Gorleku, Oforiwa Afi. "Analysis of the expression and function of mammalian CSP isoforms." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5918.

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Exocytosis, the fusion of intracellular vesicles with the plasma membrane, is fundamental to intercellular communication in multicellular organisms. This pathway facilitates the release or secretion of molecules from the cell. In addition, exocytosis is essential for delivery of resident proteins to the plasma membrane. There are two different pathways of exocytosis, constitutive and regulated exocytosis. Constitutive exocytosis occurs without regulation, e.g. pathways regulating the delivery of lipids and ‘house-keeping’ proteins to the plasma membrane or the secretion of antibodies and extra

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49

Grant, Alastair C. G. "The effect of cell volume on mammary gland metabolism." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368747.

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50

Duncan, Jennifer Sarah. "Investigations into the secretory pathway of mammary epithelial cells." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263902.

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