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Dissertations / Theses on the topic 'Proto-oncogenes'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Gerlinger, Emmanuel. "Proto-oncogenes et developpement embryonnaire : etude bibliographique." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M202.

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2

Bennett, Julie Denise. "Cell cycle regulation of B-myb transcription." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362337.

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3

Ewels, Philip Andrew. "Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/245861.

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The eukaryotic cell nucleus is a highly organised organelle, with distinct specialised sub- compartments responsible for specific nuclear functions. Within the context of this functional framework, the genome is organised, allowing contact between specific genomic regions and sub-compartments. Previous work has shown that genes in both cis and trans can make specific contacts with each other. I hypothesise that such a preferred juxtaposition may impact the propensity for specific cancerinitiating chromosomal translocations to occur. In this thesis, I describe how I have extended and developed

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4

Maxwell, Marius. "Expression of proto-oncogenes and growth factors in glioblastoma multiforme." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259967.

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5

Kemble, David J. "A biochemical study on the regulation of the SRC and FGFR family of protein tyrosine kinases /." View online ; access limited to URI, 2009. http://0-digitalcommons.uri.edu.helin.uri.edu/dissertations/AAI3367994.

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6

Baker, David Alan. "Mutational analysis of the proto-oncogenes c-fms and c-kit." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362390.

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7

Veal, Elizabeth Ann. "The role of proto-oncogenes in normal and dystrophic skeletal muscle." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307666.

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8

Cerutti, Janete Maria. "Analise do papel de c-MYC no processo de transformação das celulas foliculares da tireoide humana." [s.n.], 1995. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317287.

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Orientador: Solange Bento Farah<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-20T13:10:27Z (GMT). No. of bitstreams: 1 Cerutti_JaneteMaria_D.pdf: 5121566 bytes, checksum: bf43be08156195f0d58ec199165339ea (MD5) Previous issue date: 1995<br>Doutorado<br>Genetica<br>Doutor em Ciências Biológicas

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9

Lyon, Jonathan James. "The role of c-Myb in the regulation of haemopoiesis." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307259.

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10

Amouyel, Philippe. "Expression des proto-oncogenes ets dans les astrocytes et dans les tumeurs astrocytaires." Lille 2, 1988. http://www.theses.fr/1988LIL2M054.

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11

Corcos, Daniel. "Etude de l'expression des proto-oncogenes dans le foie normal et cancereux chez le rat." Paris 7, 1988. http://www.theses.fr/1988PA077042.

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Augmentation correlee de l'expression des trois genes ras dans les tumeurs et egalement dans les parties non tumorales des foies cancereux. L'etude des variations physiologiques de l'expression des protooncogenes a revele un controle alimentaire de l'expression du gene c-myc

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12

Chui, Chung-hin. "Molecular characterization of C-KIT proto-oncogene in Hong Kong leukemia patients : 'culprit or bystander' /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1947037X.

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13

Zhu, Jiang. "HOXB5 cooperates with TTF1 in the transcription regulation of human RET promoter." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43278607.

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14

Bidshahri, Arezoo (Roza). "Novel ultra-sensitive digital PCR assays for screening and detection of rare missense mutations in (proto)-oncogenes." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62151.

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Somatic mutations can lead to cancer, often by altering the activity of kinases within signaling pathways that control cell growth and proliferation. Targeted cancer therapeutics are designed and used to regulate these aberrant signaling pathways in cases where somatic mutations within kinase genes predict a positive patient response to those treatments. For example, the V600E mutation in BRAF, the gene coding for the BRAF serine threonine kinase, predicts the effectiveness of vemurafenib in treating metastatic melanoma, while the mutational status of codons G12/G13 in the KRAS gene predicts l

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15

Ballantyne, Eric Sinclair. "The expression and prognostic role of proto-oncogenes and tumour suppressor genes in medulloblastoma and embryonic brain." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366487.

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16

Siqueira, Débora Rodrigues. "Influência das variantes genéticas do proto-oncogene RET na apresentação clínica da neoplasia endócrina múltipla tipo 2." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/61883.

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O carcinoma medular de tireóide (CMT) é uma neoplasia das células C ou parafoliculares da tireóide, correspondendo a 5–8% dos tumores malignos da glândula. O CMT apresenta-se como um tumor esporádico (75-80%) ou na forma hereditária (20-25%). Na forma familiar é um dos componentes de uma síndrome genética de herança autossômica dominante, apresentando-se isoladamente, como carcinoma medular de tireóide familiar (CMTF) ou como um dos componentes da neoplasia endócrina múltipla (NEM) 2A ou 2B. A síndrome genética NEM 2A caracteriza-se pela presença de CMT (95%), feocromocitoma (30 – 50%) e hiper

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17

SENAN, FREDERIQUE. "Etude du role des proto-oncogenes ets1, ets2 et fli au cours du developpement embryonnaire de xenopus laevis." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13103.

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Cette these decrit le clonage et l'etude de l'expression spatio-temporelle de 3 proto-oncogenes de la famille ets chez xenopus laevis. Une strategie basee sur la conservation de sequence existant entre les differents membres de la famille, nous a permis d'isoler les adnc ets1, ets2 et fli de xenope. L'etude de l'expression temporelle du gene ets1 a ete realisee en northern blot. Parmi les 4 transcrits ets1 detectes, deux transcrits (7,5 kb et 4,4 kb) sont majoritaires. Ils apparaissent des les stades ovocytaires et restent presents lors de l'embryogenese precoce, pour disparaitre au moment de

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18

Zhu, Jiang, and 朱江. "HOXB5 cooperates with TTF1 in the transcription regulation of human RET promoter." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278607.

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19

Puñales, Márcia Khaled. "Rastreamento genético do carcinoma medular de tireóide: identificação de mutações no protooncogene "ret"." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2000. http://hdl.handle.net/10183/115378.

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O carcinoma medular de tireóide (CMT) é responsável por 5 a 8% dos tumores malignos da tireóide, ocorrendo na forma esporádica (80%) ou hereditária (20%). O CMT hereditário é uma doença autossômica dominante, maligna, de difícil diagnóstico clinico-laboratorial precoce e de alta mortalidade, podendo apresentar-se como componente das síndromes de Neoplasia Endócrina Múltipla (NEM 2A e 2B) ou Carcinoma Medular de Tireóide Familiar (CMTF) ou outras formas (famílias não incluídas nas formas anteriores). A síndrome genética NEM 2A se caracteriza por CMT (95%), feocromocitoma (30-50%) e hiperparatir

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20

Chui, Chung-hin, and 徐宗憲. "Molecular characterization of C-KIT proto-oncogene in Hong Kong leukemia patients: 'culprit or bystander'." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31236790.

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21

Haeri, Hosseini S. Mohammad. "The effects of ectopic expression of TAL1 and LMO1 on lipoprotein lipase in NIH 3T3 cells." Virtual Press, 2003. http://liblink.bsu.edu/uhtbin/catkey/1273265.

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Childhood acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Several proto-oncogenes that encode nuclear proteins are activated by various chromosomal translocations in ALL including TALI, TAL2, and LMO1 and LMO2. Ectopic TALI expression is observed in about 50 % of T-ALL and is the most common genetic anomaly associated with this pathology. Of interest to the present work is the characterization of various multiprotein complexes and protein protein interactions that drive T-ALL progression (as it relates to TALI and LMO1) and over expression of TALI and LMO1 has bee

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22

CHALKIOPOULOU-MARX, MARIA. "Modification des genomes viraux et transduction de proto-oncogenes au cours de la replication des retrovirus dans les cellules aviaires." Paris 11, 1991. http://www.theses.fr/1991PA112001.

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Dans la premiere partie de cette these, nous avons etudie la generation des mutants du virus du sarcome de rous, defectifs pour la transformation (td) dans les fibroblastes embryonnaires normaux de caille, et dans une lignee de fibroblastes de caille immortalisee (lignee q3b). Nous avons montre que le phenotype de la cellule hote influence le taux de production des virions td. Les cellules q3b produisent en grand exces des mutants td avec des deletions localisees dans la partie 5 du gene v-src. Elles sont generees par des mecanismes multiples. Nous avons isole le mutant td dlpa105 qui porte un

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23

Vieira, Alexandre Eduardo Franzin. "Rastreamento bioquimico e molecular de portadores assintomaticos de neoplasia endocrina multipla tipo 2A." [s.n.], 2001. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310740.

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Orientadores: Margaret de Castro, Maricilda Palandi de Mello<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-07-29T02:58:30Z (GMT). No. of bitstreams: 1 Vieira_AlexandreEduardoFranzin_M.pdf: 20009161 bytes, checksum: 754755440e3dcdf556da021e2b78a147 (MD5) Previous issue date: 2001<br>Resumo: A Neoplasia Endócrina Múltipla (NEM) tipo 2A é caracterizada pela presença de Carcinoma Medular de Tireóide (CMT), feocromocitoma e hiperparatireoidismo. Esta síndrome pode ser diagnosticada em portadores assintomáticos pert

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24

Gebler, Christina [Verfasser], Frank [Gutachter] Buchholz, and Axel [Gutachter] Roers. "Developing the CRISPR/Cas-system for Inactivation of Proto-oncogenes in Human Cancer Cells / Christina Gebler ; Gutachter: Frank Buchholz, Axel Roers." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://d-nb.info/1227196482/34.

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25

LIDEREAU, WEINSTEIN ROSETTE. "La variabilite genetique des proto-oncogenes ras, myc et mos comme marqueur de predisposition et d'evolution dans le cancer du sein." Paris 7, 1987. http://www.theses.fr/1987PA077129.

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26

Queiroz, Julia de Souza 1982. "Atividade moduladora da alga Chlorella vulgaris sobre alterações neuroendócrinas e hematopoéticas causadas pelo estresse." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309859.

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Orientadores: João Palermo Neto, Antonio Armario Garcia<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T19:54:17Z (GMT). No. of bitstreams: 1 Queiroz_JuliadeSouza_D.pdf: 6420413 bytes, checksum: 5de0fbd4bbb6451ff5729cbdc2fc74ce (MD5) Previous issue date: 2012<br>Resumo: A exposição do organismo a estressores psicossociais e ambientais altera de forma significativa o funcionamento do sistema imune. Os efeitos do estresse sobre a resposta imune têm sido atribuídos, principalmente, à ativação do eixo hipotálamo-pit

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27

Olum, Jimmy. "EXPRESSION OF THE THREE PROTO-ONCOGENES, EGFR, MEK AND B-RAF AFTER TRANSFECTION INTO HUMAN CELLS AND THEIR DETECTION BY MASS SPECTROMETRY." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-25604.

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When activated by growth factors and mitogens, cellular receptors like EGFR become activated and transmit signals from the cell surface through the MAPK pathway into the nucleus of the cell, in order to elicit a cellular response like growth, apoptosis, proliferation, and survival. Over activation of EGFR even without receptor binding and members of the MAPK pathways like BRAF and MEK1 have been reported in tumorigenesis. We used Gateway Technology to study the recombinant protein expressions from these 3 proto-oncogenes in HEK293T and HeLa cell lines, using pLenti 6.3/V5 as the expression sys

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28

Janet, Thierry. "Etudes sur le facteur de croissance fibroblastique basique (bfgf) : localisation, effets sur la proliferation cellulaire, mecanismes d'action et expression de proto-oncogenes." Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR13015.

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Nous avons montre que: 1) le bfgf non denature par la chaleur migre a une position inhabituelle (27 kd) par electrophorese en presence de sds, et conserve son activite biologique; 2) le bfgf est localise dans les neuroblastes de rat et de poulet en culture; 3) l'effet mitogenique du bfgf sur les astroblastes et les fibroblastes de meninges peut etre potentialise par le tgf1 (mitogene des fibroblastes) et par l'acide retinoique mitogene pour les deux types cellulaires. L'amp cyclique stimule sensiblement l'effet du bfgf dans certaines conditions. Dans les astroblastes, les oligodendroblastes (e

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29

Dutenhefner, Simone Elisa. "Pesquisa da mutação T1799A do gene BRAF e a presença de metástases linfáticas no carcinoma papilífero da tireoide." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-24012012-163817/.

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Muitos pacientes submetidos à tireoidectomia por Carcinoma Papilífero da Tireoide (CPT) têm doença linfonodal subclínica no momento da cirurgia. A mutação BRAF T17799A (V600E) é um evento comum no CPT e alguns estudos demonstram correlação entre a mutação e características de maior agressividade tumoral, incluindo a presença de metástases linfonodais. O esvaziamento eletivo do compartimento central ganha aceitação, uma vez que alguns estudos evidenciam que a presença de metástases linfonodais aumenta o risco de recidiva e mortalidade. Devido ao grande potencial de complicações do esvaziamento

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30

MATSUYAMA, MUTSUSHI, R. KAZUHIKO UTSUMI, AKIRA MASUDA, MASAHIDE TAKAHASHI, WORAWIDH WAJJWALKUI, and YOSHIHISA SAKAI. "Expression of Proto-Oncogenes and Tumor Suppressor Genes in in vitro Cell Lines Derived from a Thymus, Thymoma, and Malignant Thymoma of Rats." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/17542.

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31

Espindola, Marilia Bittencourt. "Expressão imunoistoquímica da proteína bcl-2 em metástases de melanoma cutâneo e relação com a sobrevida." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/11425.

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A morte celular programada (apoptose) tem sido implicada no desenvolvimento tumoral e no potencial metastático. O Bcl-2, um proto-oncogene inibidor da apoptose, vem sendo estudado em várias neoplasias incluindo o Melanoma Cutâneo (MC). Esse estudo avaliou a expressão imunoistoquímica da proteína bcl-2 em 35 metástases linfonodais regionais, 28 metástases subcutâneas e 17 metástases viscerais de MC e correlacionou com a sobrevida. O tempo médio de acompanhamento foi de 29,7 meses nas metástases linfonodais, 23,1 meses nas metástases subcutâneas e 22,9 meses nas metástases viscerais. A expressão

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32

DERAMAUDT, BERTRAND. "Role des proto-oncogenes fli-1 et erg dans l'expression du gene de l'heme oxygenase-1 humaine, caracterisation et etude de leurs sites de fixation a l'adn." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13089.

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L'heme oxygenase-1 (ho1) est une enzyme degradant l'heme en biliverdine, fer et monoxyde de carbone. On observe une surexpression de ho-1 dans de nombreuses pathologies. La regulation du gene ho-1 est encore mal connue, du fait des nombreux transactivateurs susceptibles de moduler son expression. Le promoteur du gene ho-1 presente de nombreux sites de liaison de differents facteurs de transcription dont certains pourraient etre reconnus par des membres de la famille des genes ets. Cette famille de genes code pour des facteurs de transcription se liant a l'adn sur des sequences caracterisees pa

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33

LEVY, RAFAEL. "Oncogenes, facteurs de croissance et cancers du sein : revue de la litterature, etude de la regulation du recepteur a l'igf 1 dans la lignee mcf-7 et des polymorphismes des proto-oncogenes c-ha-ras 1 et c-mos dans des cas familiaux." Lille 2, 1989. http://www.theses.fr/1989LIL2M316.

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34

Pimenta, Vanessa de Sousa Cruz. "Avaliação histoquímica e da expressão das proteínas p53 e c-KIT no mastocitoma canino." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tede/3576.

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Submitted by Jaqueline Silva (jtas29@gmail.com) on 2014-11-07T16:47:10Z No. of bitstreams: 2 Dissertalçao - Vanessa de Sousa Cruz Pimenta - 2012.pdf: 3213134 bytes, checksum: b135b98e005a73bd0b991b974142808b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2014-11-07T16:47:28Z (GMT) No. of bitstreams: 2 Dissertalçao - Vanessa de Sousa Cruz Pimenta - 2012.pdf: 3213134 bytes, checksum: b135b98e005a73bd0b991b974142808b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b863

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Maino, Marcelo Marafon. "Expressão imunoistoquímica de CD117 no carcinoma epidermóide de esôfago." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/53132.

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Objetivo: Investigar a expressão imunoistoquímica de CD117 em um grupo de pacientes com carcinoma epidermóide de esôfago Pacientes e Métodos: Vinte e sete pacientes com carcinoma epidermóide de esôfago submetidos à ressecção cirúrgica no Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul foram avaliados para imunoreatividade do CD117. Como grupo controle, foram utilizadas biópsias de mucosa esofágica de dez indivíduos saudáveis. A avaliação imunoistoquímica dos tecidos foi realizada com anticorpo monoclonal anti-CD117 (DAKO). Resultados: Foram avaliados 21 (78%)

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Borivoj, Sekulić. "Klinički i prognostički značaj ekspresije gena EVI1 u akutnoj mijeloidnoj leukemiji." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=95501&source=NDLTD&language=en.

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UVOD: Akutna mijeloidna leukemija (AML) predstavlja heterogenu grupu oboljenja u odnosu na morfologiju, citogenetiku, molekularnu genetiku, zbog čega se deli na različite kliničke i biolo&scaron;ke entitete, sa različitim odgovorom na terapiju i ishodom lečenja. Humani EVI1 (ecotropic virus integration-1) gen ima ulogu multifunkcionalnog nuklearnog transkripcionog faktora, kako u normalnoj tako i u malignoj hematopoezi. Sve je vi&scaron;e istraživanja koja ističu negativni prognostički značaj visoke ekspresije (overexpression) EVI1 gena u AML.  CILJEVI: Ciljevi ovog istraživanja su da se

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Quattrochi, Brian J. "Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/776.

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Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies in the United States, with an average five-year survival rate of just 6.7%. One unifying aspect of PDAC is mutational activation of the KRAS oncogene, which occurs in over 90% of PDAC. Therefore, inhibiting KRAS function is likely an effective therapeutic strategy for this disease, and current research in our lab and others is focused on identifying downstream effectors of KRAS signaling that may be therapeutic targets. miRNAs are powerful regulators of gene expression that can behave as oncogenes or tumor suppressor

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Quattrochi, Brian J. "Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/776.

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Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies in the United States, with an average five-year survival rate of just 6.7%. One unifying aspect of PDAC is mutational activation of the KRAS oncogene, which occurs in over 90% of PDAC. Therefore, inhibiting KRAS function is likely an effective therapeutic strategy for this disease, and current research in our lab and others is focused on identifying downstream effectors of KRAS signaling that may be therapeutic targets. miRNAs are powerful regulators of gene expression that can behave as oncogenes or tumor suppressor

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39

Li, Ling. "Mechanisms Underlying Apoptosis Inhibition and Transcription Repression by Ski." Connect to text online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1118235807.

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Bessa, Tiphany Coralie de. "Mecanismo associados à perda da regulação da nox1 NADPH oxidase pela dissulfeto isomerase proteica em células com ativação sustentada da via ras." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-03072018-090616/.

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Dissulfeto isomerase proteica como a PDIA1 tem sido implicada na progressão do câncer, porém os mecanismos envolvidos ainda não foram claramente identificados. Previamente, nós demonstramos um importante efeito da PDIA1 induzindo a superexpressão da Nox1 NADPH oxidase, associada à geração de espécie reativas de oxigênio (ROS). Uma vez que a perda na regulação de ROS envolve o crescimento tumoral, nós propusemos que a PDIA1 atua como um mecanismo regulador proximal na produção de ROS em tumores. No presente estudo, nós focamos no câncer colorretal (CRC) com distintos efeitos na ativação de KRas

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41

LE, ROUZIC ERWANN. "Activation insertionnelle du proto-oncogene c-myb dans une lignee de lymphome transformee par le virus de marek (mdv) : un exemple de cooperation des oncogenes c-myb et meq dans l'induction et le maintien du phenotype transforme ?" Paris 6, 1997. http://www.theses.fr/1997PA066437.

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Le proto-oncogene c-myb est l'homologue cellulaire de l'oncogene transformant v-myb porte par deux retrovirus leucemogenes, amv et e26. Le gene c-myb code un facteur de transcription et est preferentiellement exprime dans les cellules hematopoietiques immatures. L'alteration de son expression ou/et de son activite est etroitement associee a des leucemies chez les vertebres. Le virus de la maladie de marek (mdv) appartient a la famille des virus herpes et induit des lymphomes de type t chez les aviaires. De nombreux travaux ont permis de proposer un role pour les genes associes au fragment bamh

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HUNTS, JOHN HOWARD. "ANALYSIS OF THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR GENE AS A PROTO-ONCOGENE (SQUAMOUS CELL CARCINOMA)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183865.

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The epidermal growth factor receptor (EGFR) gene was examined as a proto-oncogene. Initially, the cellular homolog of the retroviral oncogene erb-B was shown to be localized to the same region of human chromosome 7 as the EGFR gene, giving support to the idea that these genes are closely related. To determine how some cells can over-express the EGFR gene, somatic cell hybrids constructed between a human EGFR-overproducing cell line and a mouse EGFR-deficient cell line were examined. EGFR gene amplification was observed in one of these hybrids along with EGFR gene rearrangement, which is though

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Santos, Marcelo Augusto Cortina Gonçalves dos. "Detecção e rastreamento de mutações no proto-oncogene RET em pacientes com neoplasia endócrina múltipla tipo 2 por meio de eletroforese em gel sensível à conformação." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-06062007-170334/.

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A neoplasia endócrina múltipla tipo 2 (NEM-2) é uma síndrome tumoral herdada por mutações germinativas no proto-oncogene RET (RET) e transmitida por herança autossômica dominante. Atualmente, a indicação de tireoidectomia total preventiva é recomendada a indivíduos portadores de mutações no RET. Analisamos a aplicação do método Eletroforese em Gel Sensível à Conformação (CSGE) no rastreamento de mutações hot-spots do RET. Sete famílias com NEM-2 foram rastreadas pelo CSGE, seqüenciamento gênico e análise do Polimorfismo Conformacional de Cadeia Simples (SSCP). Usando o CSGE e SSCP, identificam

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Schiavi, Susan C. "MYC and E1A Oncogenes Alter the Response of PC12 Cells to Nerve Growth Factor and Block Differentiation: A Thesis." eScholarship@UMMS, 1988. https://escholarship.umassmed.edu/gsbs_diss/259.

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PC12 rat pheochromocytoma cells respond to nerve growth factor (NGF) by neuronal differentiation and partial growth arrest. Mouse c-myc and adenovirus E1A genes were introduced into PC12 cells to study the influence of these nuclear oncogenes on neuronal differentiation. Expression of myc and E1A blocked morphological differentiation and caused NGF to stimulate rather than inhibit cell proliferation. NGF binding to cell surface receptors, activation of ribosomal S6 kinase, and ornithine decarboxylase induction were similar in myc and E1A expressing clones compared with wild-type PC12 cells, su

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WENG, FEN-HUA, and 翁芬華. "Expression of oncogenes (Proto-oncogenes) in human esophageal carcinoma cells." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/14401428271251077373.

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CAI, TING-FEN, and 蔡亭芬. "Structure and expression of oncogenes (proto-oncogenes) in human hepatoma cell lines." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/24442076299052261461.

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QIU, XIAN-TAI, and 邱顯泰. "The effects of IGF-I on the transcription of nuclear proto-oncogenes." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/70721849386099690157.

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ZHANG, JUN-ZHE, and 張俊哲. "Expression of several proto-oncogenes and homeogenes in bull frog liver during metamorphosis." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/06803186295645365746.

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Chang, Hung-Chi, and 張宏基. "Expression of nitric oxide synthase and nuclear proto-oncogenes in Angiostrongylus cantonensis-infected mice." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/25048612309578120665.

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碩士<br>中山醫學院<br>生物化學研究所<br>87<br>The purpose of this study was to investigate the pathogenic mechanism of Angiostrongylus cantonensis (A.c) male ICR mice were used as experimental animals and divided into experimental group and control group. Each mouse in the experimented group was fed with 30 third stage larvae of Angiostrongylus Cantonensis certain number of animals were sacritied each week after infection till the sixth week to collect blood and brain tissues which were further analyzed by SDS-PAGE and Western blot to identify the change in protein expression the pathogenic mechanism was

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Gebler, Christina. "Developing the CRISPR/Cas-system for Inactivation of Proto-oncogenes in Human Cancer Cells." Doctoral thesis, 2017. https://tud.qucosa.de/id/qucosa%3A31120.

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Numerous mutations contribute to tumorigenesis of cancer cells. For most of them it remains unclear whether they are driver or passenger mutations. A classic knock-out to study their function in cancer cells used to take a lot of effort. The CRISPR/Cas-system can be used as a programmable “genome editing” tool. In this work, oncogenes have been inactivated with the CRISPR/Cas-system. Considering off-targets, Streptococcus pyogenes sgRNAs can be designed for 88% of the known cancer mutations. The activity of 15 sgRNAs, targeting 13 mutations in proto-oncogenes (deletions, insertions and point

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