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Dissertations / Theses on the topic 'Protocatechuic acid'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Pujari, Twarita Anil. "Cocrystals of nutraceuticals: Protocatechuic acid and quercetin." Scholar Commons, 2009. http://scholarcommons.usf.edu/etd/2156.

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The cocrystallization of two or more pure compounds by crystal engineering to create a new functional material is of a great academic and industrial interest. Pharmaceutical cocrystallization has allured a lot of attention by means of altering the physicochemical properties of Active Pharmaceutical Ingredient (API) such as solubility, stability and bioavailability. Crystal engineering of nutraceuticals can produce novel compounds such as pharmaceutical cocrystals. To establish the importance of nutraceutical cocrystallization and its use; polyphenols, a major class of nutraceuticals and potent

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2

Soares, Luciana Arantes [UNESP]. "Estudo da atividade antidermatofitica de Protocatecuatos contra T. rubrum e T. interdigitale." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/94784.

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Made available in DSpace on 2014-06-11T19:27:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-11-23Bitstream added on 2014-06-13T20:16:29Z : No. of bitstreams: 1 soares_la_me_arafcf.pdf: 482117 bytes, checksum: 977f1b9fe29b6c45730789f06700afaa (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Universidade Estadual Paulista (UNESP)<br>São evidentes a necessidade de novas substâncias antifúngicas e a grande importância dos produtos naturais no desenvolvimento de novas ferramentas terapêuticas. Assim, neste estudo avaliou-se a atividade antifúngica dos der

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3

Soares, Luciana Arantes. "Estudo da atividade antidermatofitica de Protocatecuatos contra T. rubrum e T. interdigitale /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/94784.

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Orientador: Ana Marisa Fusco Almeida<br>Banca: Anderson Assunção Andrade<br>Banca: Luis Octávio Regasini<br>Resumo: São evidentes a necessidade de novas substâncias antifúngicas e a grande importância dos produtos naturais no desenvolvimento de novas ferramentas terapêuticas. Assim, neste estudo avaliou-se a atividade antifúngica dos derivados sintéticos esterificados do ácido protocatecuico. Todos os isolados apresentaram bons resultados ao teste de suscetibilidade aos derivados sintéticos do ácido protocatecuico demonstrando que 62,5% foram ativos em relação para dois isolados de T. rubrum (

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4

Grajeda-Iglesias, Claudia. "Valorisation d’extraits végétaux par la synthèse et caractérisation de composés phénoliques lipophilisés." Thesis, Montpellier, SupAgro, 2016. http://www.theses.fr/2016NSAM0005.

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Les composés phénoliques sont des métabolites secondaires chez les végétaux, qui possèdent un large éventail de propriétés biologiques et fonctionnelles, par exemple antioxydantes, antimicrobiennes. Comme ils sont très répandus dans le règne végétal, les sous-produits issus de la transformation végétale représentent une source intéressante et peu coûteuse des polyphénols qui pourraient être utilisés comme additifs naturels, inoffensifs et multifonctionnels, avec une valeur de marché ajoutée. Toutefois, leur polarité limite leur utilisation dans des systèmes émulsionnés complexes, tels que ceux

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5

Zheng, Yu Xin, and 鄭玉新. "Protective effects of protocatechuic acid and oxidative polymer of protocatechuic acid on the oxidative damage of rat liver mitochondria." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/95649147890227752106.

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碩士<br>國立臺灣大學<br>生化學研究所<br>84<br>The mitochondria palyed a vital role on the bioenergenesis. Many disease free radicals species released from mitochondria. In the present study, we want to test the ability of the anti- oxidative effect of PCA and its oxidative polymer to protect the oxidative damage of mitochondria. Four indices on the oxidative damage of the rat liver mitochondria were used. We directly used ultra-sensitive

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6

Tsai, Che-Hsiu, and 蔡哲秀. "Applications of derivatives of synthetic protocatechuic acid and caffeic acid on cosmetics." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/26205985261419265636.

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碩士<br>嘉南藥理科技大學<br>化妝品科技研究所<br>94<br>Abstract 　　This research utilizes the method of organic synthesis to put protocatechuic acid and caffeic acid into esterification or amidation process so as to produce a series of esters (No. 1 ~ 10) and amides (No. 11 ~ 16). By way of tests on DPPH antioxidant capability, inhibit- tive capability on the vitality of tyrosinase, MTT cell toxicity test and appraisal of validity of human body, their practical values in cosmetics will be further discussed. 　　The experiment on antioxidant capability shows that: the alkyl ester esterification derivatives of protoc

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7

Li, Mei-Ling, та 李美玲. "High Molecular Protocatechuic Acid Polymers Induces Atherosclerosis and NF-κB Activation". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/69568877193594605519.

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碩士<br>中國醫藥大學<br>營養學系碩士班<br>94<br>High molecular Protocatechuic acid polymer (humic acid, HA) have been implicated as an etiological factor of Blackfoot disease (BFD) endemic in the southwest coast of Taiwan. In this study, we investigated the effect of HA on atherosclerosis and activation of nuclear factor – kappa B (NF-κB). In animal study, we suggest HA can increase the atherosclerosis. This increase was not due to increasing in serum cholesterol and triacylglycerol (TG). In vitro study, HA was shown to enhance (1) activation of adhesion molecular (ex: intercellular cell adhesion molecule-1,

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8

Wu, Sih-Han, and 吳思頷. "Effects Of Exercise And Protocatechuic Acid On Cardiovascular Function In Hypertension." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/05584999797612566197.

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碩士<br>臺北市立體育學院<br>運動科學研究所<br>100<br>Background and purpose：Oxidative stress elevation plays an important role in the pathogenesis of endothelial dysfunction and hypertension. Previous studies have indicated that the Protocatechuic acid (PCA) has strong antioxidant capacity. Moreover, exercise has been known to improve cardiovascular function. However, few research explored and compared the effects of PCA and exercise intervention on cardiovascular function in hypertension. Thus, the purpose of this study was to investigate the effects of long-term PCA and exercise intervention on cardiovascula

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9

Chang, Ching-Tsao, and 張欽肇. "The protective effects of protocatechuic acid and caffeic acid on the free radicals induced DNA damage." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/52231089486525882815.

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碩士<br>嘉南藥理科技大學<br>化妝品科技研究所<br>96<br>This research utilizes the method of organic synthesis to the alkyl ester esterification derivatives of protocatechuic (No. 1 ~ 7)、the amidation derivatives of protocatechuic (No. 11 ~ 13) and the alkyl ester esterification derivatives of caffeic(No. 8 ~ 10)、the amidation derivatives of caffeic(No. 14 ~ 16). Through the way of testing on DPPH antioxidant capability, inhibit capability on the vitality of hydrogen peroxide and Trolox Equivalent Antioxidant Capacity,the effect on liposome assay , tests on NO antioxidant capability、the protective effects on the

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10

陳靜儀. "Studies on the Mechanisms of atherosclerosis by high molecular Protocatechuic acid polymers." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/46802823409386712795.

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碩士<br>中國醫藥大學<br>營養研究所<br>92<br>part I Blackfoot disease (BFD) is a peripheral arterial occlusive disease found among the inhabitants of the southwest coast of Taiwan. High molecular protocatechuic acid polymers-humic acid (HA) is a group of polymer with high molecular weight macromolecules derived from the decomposition of organic matter, especially in the dead plant. It exists abundantly in peat, soil, well water, and other sources. HA has been implicated as an etiologic factor in the vasculopathy of Blackfoot disease. In this study, we investigate on the mechanism of aggregation o

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11

HUANG, Yi-Ching, and 黃怡菁. "Anti-apoptotic and Pro-survival Effect of Protocatechuic Acid on Hypertensive Hearts‏." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/18433134017465797219.

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碩士<br>亞洲大學<br>生物科技學系碩士班<br>99<br>Background. Activated cardiac apoptosis was found in hypertension but less information regarding the effects of protocatechuic acid on cardiac apoptosis in hypertension was available. The purpose of this study was to evaluate the anti-apoptotic and pro-survival effects of protocatechuic acid on hypertensive hearts. Methods. Eighteen spontaneously hypertensive rats, were divided into sedentary group(SHR) and underwent feeding PCA 0.01mg/ml,(0.2/kg BW) mixed in water,3 times per week(on the first ,third and fifth days of each week)for 8 weeks (SHR-PCA). Ten Wista

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12

Lin, Yu-Mei, and 林郁玫. "Effects of Protocatechuic Acid Supplementation on Cardiovascular Function in Ovariectomized Hypertensive Rats." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/90804723514200019269.

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碩士<br>臺北巿立體育學院<br>運動科學研究所<br>101<br>Background and purpose: The American Heart Association has reported that the prevalence of hypertension-related cardiovascular complications is higher in postmenopausal women than in age-matched men. The possible causes of hypertension in postmenopausal women could be due to endothelial dysfunction, and increased oxidative stress, and arterial stiffness. There is growing evidence that polyphenols exert antioxidant effects to ameliorate the cardiovascular function. A simple phenolic acid, protocatechuic acid (PCA; 3,4-dihydroxybenzoic acid), shows a potent an

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13

Hsieh, Ming-Hsun, and 謝銘薰. "Inhibitory effect and action mechanisms of esculetin and protocatechuic acid on LDL oxidation." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/18529931883782466962.

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碩士<br>中山醫學院<br>生物化學研究所<br>88<br>英文摘要 The oxidation of low-density lipoprotein (LDL) could increase the incidence of atherosclerosis. In previous studies showed that copper and nitroprusside possessed the ability to oxidize LDL in dose-dependent condition. They increased the negative charge existing in LDL and increased the electrophoretic mobility. On the other side, many antioxidants were observed to lower the formation of atherosclerosis such as Vit.E, Vit C and -carotene. These antioxidants reduced the relative electrophoretic mobilities (REM) and thiobarbituric acid-reactive su

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Chiang, Min-Yen, and 江旻諺. "Comparison of Exercise and Protocatechuic Acid on Bone Structure in Ovariectomized Hypertensive Rats." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/38193005379755240625.

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碩士<br>臺北巿立體育學院<br>運動科學研究所<br>101<br>Background and purpose: The postmenopausal woman has high risk of cardiovascular disease, such as hypertension. Evidences indicate that high blood pressure is associated with abnormalities of calcium metabolism, leading to an increase in calcium loss. Previous studies have indicated protocatechuic acid (PCA) has strong antioxidant capacity and could be beneficial for hypertension. Moreover, exercise has been known to improve and prevent the osteoporosis. However, few studies explored and compared the effects of PCA and exercise intervention on bone histomorp

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15

Han, Yi-Han, and 韓伊涵. "The inhibitory effects of protocatechuic acid on UVB-induced melanogenesis and collagen degeneration." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/14997555102615202776.

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碩士<br>中華醫事科技大學<br>生物科技研究所<br>99<br>Ultraviolet radiation (UV) is the cause of many skin diseases, and UV exposing on long-time could cause the injury of skin cells. The use of phytonutrient as anti-UV agents has gained considerable importance in recent years. Protocatechuic acid (PCA) is discussed to represent antioxidative food components in a human diet rich in fruits and vegetables, and has been shown to prevent carcinogenesis or antitumor growth in vivo and in vitro. However, the studies involved in chemopreventive activity of beauty and health care of PCA are poorly few. In this study inv

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16

KUNANYA, MASODSAI, and MASODSAI KUNANYA. "Aging-related Cardiovascular Dysfunction in Hypertension and its Reversal through Exercise and Protocatechuic Acid." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/7ndqb9.

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博士<br>臺北市立大學<br>運動科學研究所<br>107<br>Background and purpose: Based on the epidemiological studies, the prevalence of hypertension may unavoidably increase with advancing age. Both of hypertension and aging have remarkable effects on cardiovascular disorders, particularly endothelial dysfunction. Regular exercise has been proved as the non-pharmacological strategy in prevention and treatment for hypertension. In addition, natural polyphenolic compounds, such as protocatechuic acid (PCA), have been reviewed for various actions in health promotion, including cardiovascular-protective effects. In the

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17

Pan, Amanda, and 潘家穎. "The Kinetic Studies of the Outer-Sphere Electron Transfer Reaction between Protocatechuic Acid and Pentacyanoferrate(III) Complexes." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/42768263851637946221.

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碩士<br>東海大學<br>化學系<br>95<br>The reductions of [Fe(CN)5L]2-(L=4-cyano-pyridine, isonicotinamide, 4,4’-bipyridine, pyridine, pyrazine)complexes by protocatechuic acid have been subjected to a detailed kinetic study in the range of pH 5 – 9. The rate law of the reaction is interpreted as a rate determining reaction between Fe(III) complexes and the protocatechuic acid in the form of H2cat-COO-(k1), Hcat-COO2-(k2), and cat-COO3-(k3), depending on the pH of the solution, follow by a rapid scavenge of the protocatechuic acid radicals by Fe(III) complex. With given Ka1, Ka2, and Ka3, the rate constant

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18

Wen, Pao-Hsiang, and 溫寶香. "Suppressive Effects of Protocatechuic Acid on the Expression of Mitogenic Signaling Proteins During TPA-induced Tumor Promotion." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/63515562977991709350.

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碩士<br>中山醫學院<br>生物化學研究所<br>86<br>Hibiscus protocatechuic acid (PCA), a simple phenolic compound, isolated from Hibiscus sabdariffa L. was studied for its molecular mechanisms on 12-0-tetradecanoy 1phorbol 13-acetate (TPA)-induced promotion of skin tumors. 　　Topical application of 5 nmol TPA to the dorsal surface of CD-1 mice twice daily for 5 days caused epidermal hyperplasia, lipid peroxidation and the enhancement of the protein levels of the singaling proteins, such as c-Fos, MEK, ERK1, ERK2 and PKC were 2.39-, 2.34-2.26-,2.47-and 2.45-fold as compared to control on TPA-treated mice epider

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Tsz, Jing, and 歐靜慈. "The effects of liquid extract of Hibiscus Sabdariffa Linnaeus and protocatechuic acid in inhibiting apoptosis and migration." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/24900980566302105003.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>93<br>In developed countries, atherosclerosis and its complications are becoming a major cause of death. Several studies showed that free radical-mediated oxidation of low density lipoprotein leading to the production of oxidized LDL (OxLDL) is a key event in initiating endothelial cells proliferation and atherosclerosis plaque. Some natural antioxidants such as vitamin C, vitamin E, β-carotene have been revealed clearly to prevent the atherosclersis. As shown in previous studies, we found that the aqueous extract of Hibiscus Sabdariffa ( HSE ) and protocatechuic

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Li, MengYin, and 李孟印. "Hibiscus Protocatechuic Acid Supplementation to Protect Oxidative Stress and Muscle Damage Induced by Exhaustive Exercise in Rat." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/63451468236027029792.

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碩士<br>國立體育學院<br>運動科學研究所<br>87<br>The purpose of this study was to investigate the exhaustive exercise-induced oxidative stress and the protective effect of supplementation of Hibiscus protocatechuic acid (PCA) on creatine kinase (CK), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPx) in rat serum. PCA, a simple pheolic compound isolated from the dried flowers of Hibiscus sabdariffa L., which is a Chinese herbal medicine. Thirty two male Sprague-Dawley rats were randomly divided into the following four groups: 1.control (C, n=8), 2.exhaustive exercise (E, n=8), 3.P

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21

Lee, Miao-Jane, and 李妙真. "Studies on the effects and mechanisms of protocatechuic acid and liquid extract of Hibiscus Sabdariffa Linnaeus in inhibiting atherosclerosis." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/11138746025545085672.

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博士<br>中山醫學大學<br>生物化學研究所<br>91<br>The natural antioxidants, such as Vit E, Vit C and beta-carotene, has been found to possess the ability to avoid LDL oxidation or reduce oxidized LDL (oxLDL) uptaken by macrophage; and furthermore, they were able to prevent the formation of atherosclerosis. In our previous studies, we explored that both protocatechuic acid (PCA) and the aqueous extract of its original plant, Hibiscus Sabdariffa (HSE), showed strong inhibitory effects on the negative charge increasing of protein moiety in oxLDL (lipogel electrophoresis) and on the lipid peroxidation of lipid moi

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