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Dissertations / Theses on the topic 'Proton beam radiotherapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Howarth, Ashley L., Joshua R. Niska, Kenneth Brooks, et al. "Tissue Expanders and Proton Beam Radiotherapy." LIPPINCOTT WILLIAMS & WILKINS, 2017. http://hdl.handle.net/10150/625389.

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Proton beam radiotherapy (PBR) has gained acceptance for the treatment of breast cancer because of unique beam characteristics that allow superior dose distributions with optimal dose to the target and limited collateral damage to adjacent normal tissue, especially to the heart and lungs. To determine the compatibility of breast tissue expanders (TEs) with PBR, we evaluated the structural and dosimetric properties of 2 ex vivo models: 1 model with internal struts and another model without an internal structure. Although the struts appeared to have minimal impact, we found that the metal TE por

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2

Handley, Stephen Michael. "Monte Carlo simulations using MCNPX of proton and anti-proton beam profiles for radiation therapy." Oklahoma City : [s.n.], 2010.

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3

Warren, Daniel Rosevear. "Proton radiotherapy uncertainties arising from computed tomography." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ab59f596-e277-490a-a7c1-1cb81b47b9a9.

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Proton radiotherapy is a cancer treatment which has the potential to offer greater cure rates and/or fewer serious side effects than conventional radiotherapy. Its availability in the UK is currently limited to a single low-energy fixed beamline for the treatment of ocular tumours, but a number of facilities designed to treat deep-seated tumours are in development. This thesis focusses on the quantitative use of x-ray computed tomography (CT) images in planning proton radiotherapy treatments. It arrives at several recommendations that can be used to inform clinical protocols for the acquisitio

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4

Parodi, Katia. "On the feasibility of dose quantification with in-beam PET data in radiotherapy with 12C and proton beams." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28788.

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This thesis has contributed to the achievement of in-beam PET as a promising clinical monitoring technique. In response to a pressing medical demand, this work has provided a tool for quantification of local dose deviations in case of observed discrepancies between the measured and expected PET images. The implemented interactive approach described in chapter 3 is in clinical use since 2001. It provides the radio-oncologist with a valuable feedback which may allow a prompt reaction in the strategy of the therapy prior to the delivery of the successive treatment fraction in case of signi

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5

Parodi, Katia. "On the feasibility of dose quantification with in-beam PET data in radiotherapy with 12C and proton beams." Rossendorf : Forschungszentrum, 2004. http://www.fz-rossendorf.de/publications/006865/6865.pdf.

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6

da, Silva Joakim. "Pencil beam dose calculation for proton therapy on graphics processing units." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/254300.

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Radiotherapy delivered using scanned beams of protons enables greater conformity between the dose distribution and the tumour than conventional radiotherapy using X rays. However, the dose distributions are more sensitive to changes in patient anatomy, and tend to deteriorate in the presence of motion. Online dose calculation during treatment delivery offers a way of monitoring the delivered dose in real time, and could be used as a basis for mitigating the effects of motion. The aim of this work has therefore been to investigate how the computational power offered by graphics processing units

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7

Mondlane, Gracinda. "Comparative study of Radiation Therapy of Targets in the Upper Abdomen with Photon- or Scanned Proton-beams." Licentiate thesis, Stockholms universitet, Fysikum, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-144550.

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Recently, there has been an increase in the number of proton beam therapy (PBT) centers operating worldwide. For certain cases, proton beams have been shown to provide dosimetric and radiobiological advantages when used for cancer treatment, compared to the regular photon-beam based treatments. Under ideal circumstances, the dose given to the tissues surrounding a target can be reduced with PBT. The risk for side effects following treatment is then expected to decrease. Until present, mainly stationary targets, e.g. targets in the brain, have been treated with PBT. There is currently a growing

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8

Ts`oeu, M. S. "Proton beam steering control system for high precision radiotherapy at iThemba LABS : an investigation on actuator saturation constraints." Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/5095.

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Includes abstract.<br>Includes bibliographical references (leaves 101-106).<br>This thesis aims at studying some of the techniques used to deal with constraints with special application to the Proton beam steering control at iThemba LABS. The steering of charged particles occurring in research plants is one of the interests of control systems. In this work an investigation of the algorithm for the control of the proton beam steering system in the radiotherapy treatment facility at iThemba LABS is conducted. This algorithm is intended to autonomously maintain the beam centered with reference to

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9

Masood, Umar. "Radiotherapy Beamline Design for Laser-driven Proton Beams." Helmholtz Zentrum Dresden Rossendorf, 2018. https://tud.qucosa.de/id/qucosa%3A35640.

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Motivation: Radiotherapy is an important modality in cancer treatment commonly using photon beams from compact electron linear accelerators. However, due to the inverse depth dose profile (Bragg peak) with maximum dose deposition at the end of their path, proton beams allow a dose escalation within the target volume and reduction in surrounding normal tissue. Up to 20% of all radiotherapy patients could benefit from proton therapy (PT). Conventional accelerators are utilized to obtain proton beams with therapeutic energies of 70 – 250 MeV. These beams are then transported to the patient via ma

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10

Sjögren, Adam. "The impact of metallic cranial implants on proton-beam radiotherapy treatment plans for near implant located tumours : A phantom study on the physical effects and agreement between simulated treatment plans and the resulting treatment for near implant located cranial tumours." Thesis, Umeå universitet, Institutionen för fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149530.

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Within the field of radiotherapy treatments of tumour diseases, the hunt for more accurate and effective treatment methods is a continuous process. For some years ion-beam based radiotherapy, especially the proton-beam based applications, has increased in popularity and availability. The main reason behind this is the fact that ion-beam based applications make it possible to modulate the dose after the planning target volume (PTV) defined by the radiation oncologist. This means that it becomes possible to spare tissue in another way, which might result in more effective treatments, especially

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11

Mu, Xiangkui. "Clinical application of intensity and energy modulated radiotherapy with photon and electron beams." Doctoral thesis, Umeå : Strålningsvetenskaper, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-443.

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12

Masood, Umar [Verfasser], Wolfgang [Akademischer Betreuer] Enghard, and Peter [Gutachter] Michel. "Radiotherapy Beamline Design for Laser-driven Proton Beams / Umar Masood ; Gutachter: Peter Michel ; Akademischer Betreuer: Wolfgang Enghard." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1234398478/34.

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13

Van, der Bijl Leendert. "Verification of patient position for proton therapy using portal X-Rays and digitally reconstructed radiographs." Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/1250.

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14

Smeets, Julien. "Prompt gamma imaging with a slit camera for real time range control in particle therapy." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209624.

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In a growing number of cutting edge centres around the world, radiotherapy treatments delivered by beams of protons and carbon ions offer the opportunity to target tumours with unprecedented conformality. But a sharper dose distribution increases the need for efficient quality control. Treatments are still affected by uncertainties on the penetration depth of the beam within the patient, requiring medical physicists to add safety margins. To reduce these margins and deliver safer treatments, different projects investigate real time range control by imaging prompt gammas emitted along the proto

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15

Schürer, Michael, Leonhard Karsch, Jörg Pawelke, Umar Masood, Thomas Herrmannsdörfer, and Florian Kroll. "Entwicklung kompakter, gepulster Elektro-Dipolmagnete für die laserbasierte Protonentherapie." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-214663.

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Hintergrund Die strahlentherapeutische Behandlung von Krebserkrankungen erfolgt zurzeit hauptsächlich durch eine Bestrahlung mit hochenergetischen Photonen und Elektronen aus kompakten Therapie-Linearbeschleunigern. Seltener werden auch Protonenstrahlen eingesetzt. Diese besitzen gegenüber Photonen und Elektronen vorteilhaftere physikalische und strahlenbiologische Eigenschaften, die besonders bei der Bestrahlung von tiefliegenden Tumoren in der Nähe von lebenswichtigen, strahlenempfindlichen Organen von Bedeutung sind. Die Behandlung mit Protonen erfordert jedoch sehr große und teure Bestrahl

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16

Neupane, Mahesh Raj. "Optimization of a sequential alignment verification and positioning system (SAVPS) for proton radiosurgery." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2784.

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Functional proton-beam stereotactic radiosurgery requires sub-millimeter alignment accuracy. A patient tracking system called Sequential Alignment and Position Verification System (SAVPS) is under development at Loma Linda University Medical Center. An optical positioning system (OPS), manufactured by Vicon Peak, has been chosen to verify the correct alignment of the target with the proton beam axis. The main objective of this thesis is to optimize an existing version of SAVPS by conducting error analysis. An image processing algorithm was developed and applied to estimate the error introduced

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17

Mondlane, Gracinda. "A comparative treatment planning study of radiotherapy of clinical liver- and stomach-cancer cases with either photon or proton beams." Thesis, Stockholms universitet, Fysikum, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-132177.

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There has been an increasing interest in proton beam therapy (PBT) in recent years related to the advantageous depth-dose characteristics of proton beams compared to what is achievable with standard external photon beam radiotherapy (RT). With PBT, improved target dose conformity can be achieved together with a reduction in the dose to the organs at risk (OARs). This can for certain cases lead to an increased tumour control probability (TCP) at the same time as the probabilities for normal tissue complications (NTCP) and radiation-induced secondary cancers are reduced. However, there are chall

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18

Müller, Birgit Sabine [Verfasser], Jan J. [Akademischer Betreuer] [Gutachter] Wilkens, and Franz [Gutachter] Pfeiffer. "Optimization of efficiency and dosimetric quality in treatment planning of intensity-modulated radiotherapy with photon and proton beams / Birgit Sabine Müller. Betreuer: Jan J. Wilkens. Gutachter: Jan J. Wilkens ; Franz Pfeiffer." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1104933837/34.

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19

Chaouni, Samia. "Effets secondaires de la radiothérapie conventionnelle et de la protonthérapie sur les tissus sains : biomarqueurs sanguins et tissulaires The possibility of using genotoxicity, oxidative stress and inflammation blood biomarkers to predict the occurrence of late cutaneous side effects after radiotherapy Side effects of scattered versus scanned proton beamson normal tissues in total body irradiated mice: survival, genotoxicity, oxydative stress and inflammation Differential normal skin transcriptiomic response in total body irradiated mice exposed to scattered versus scanned proton beams." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC416.

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Malgré les améliorations apportées, la radiothérapie conventionnelle et la protonthérapie continuent d’engendrer des toxicités sur les tissus sains. Nous avons cherché ici à évaluer les effets de l’irradiation sur les tissus sains par le biais de biomarqueurs sanguins et tissulaires chez des patients traités par radiothérapie conventionnelle ainsi que sur des modèles murins exposés à des faisceaux de protons diffusés, technique de délivrance passive du faisceau, ou balayés, nouvelle technique conduisant à une délivrance de la dose complètement différente. Nous avons pu mettre en évidence des d

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20

"Hydrogel Nanosensors for Colorimetric Detection and Dosimetry in Proton Beam Radiotherapy." Master's thesis, 2017. http://hdl.handle.net/2286/R.I.46302.

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abstract: Proton beam therapy (PBT) is a state-of-the-art radiotherapy treatment approach that uses focused proton beams for tumor ablation. A key advantage of this approach over conventional photon radiotherapy (XRT) is the unique dose deposition characteristics of protons, resulting in superior healthy tissue sparing. This results in fewer unwanted side effects and improved outcomes for patients. Current available dosimeters are intrinsic, complex and expensive; hence cannot be used to determine the dose delivered to the tumor routinely. Here, we report a hydrogel based plasmonic nanosensor

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21

Ransome, Trevor Malcolm. "Automatic Minimisation of Patient Setup Errors in Proton Beam Therapy." Thesis, 2006. http://hdl.handle.net/10539/1667.

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Student Number : 0003555T - MSc (Eng) dissertation - School of Electrical and Information Engineering - Faculty of Engineering and the Built Environment<br>Successful radiotherapy treatments with high-energy proton beams require the accurate positioning of patients. This paper investigates computational methods for achieving accurate treatment setups in proton therapy based on the geometrical differences between a double exposed portal radiograph (PR) and a reference image obtained from the treatment planning process. The first step in these methods involves aligning the boundary of th

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22

Guan, Fada. "Design and Simulation of a Passive-Scattering Nozzle in Proton Beam Radiotherapy." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7394.

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Proton beam radiotherapy is an emerging treatment tool for cancer. Its basic principle is to use a high-energy proton beam to deposit energy in a tumor to kill the cancer cells while sparing the surrounding healthy tissues. The therapeutic proton beam can be either a broad beam or a narrow beam. In this research, we mainly focused on the design and simulation of the broad beam produced by a passive double-scattering system in a treatment nozzle. The NEU codes package is a specialized design tool for a passive double-scattering system in proton beam radiotherapy. MCNPX is a general-purpose Mont

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23

Gonçalves, Mariana Augusto. "Proton beam radiotherapy long term complications and local control of choroidal melanomas." Master's thesis, 2014. http://hdl.handle.net/10316/37323.

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24

Guan, Fada 1982. "Application of Dynamic Monte Carlo Technique in Proton Beam Radiotherapy using Geant4 Simulation Toolkit." Thesis, 2012. http://hdl.handle.net/1969.1/149220.

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Monte Carlo method has been successfully applied in simulating the particles transport problems. Most of the Monte Carlo simulation tools are static and they can only be used to perform the static simulations for the problems with fixed physics and geometry settings. Proton therapy is a dynamic treatment technique in the clinical application. In this research, we developed a method to perform the dynamic Monte Carlo simulation of proton therapy using Geant4 simulation toolkit. A passive-scattering treatment nozzle equipped with a rotating range modulation wheel was modeled in this research.

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25

Schellhammer, Sonja. "Technical Feasibility of MR-Integrated Proton Therapy: Beam Deflection and Image Quality." 2019. https://tud.qucosa.de/id/qucosa%3A34132.

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Es wird erwartet, dass die Integration der Magnetresonanztomografie (MRT) in die Protonentherapie die Treffgenauigkeit bei der Strahlentherapie für Krebserkrankungen deutlich verbessern wird. Besonders für Tumoren in beweglichen Organen des Thorax oder des Abdomens könnte die MRT-integrierte Protonentherapie (MRiPT) eine Synchronisierung der Bestrahlung mit der Tumorposition ermöglichen, was zu einer verminderten Normalgewebsdosis und weniger Nebenwirkungen führen könnte. Bis heute ist solch eine Integration jedoch aufgrund fehlender Studien zu potenziellen gegenseitigen Störeinflüssen dieser

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26

Masood, Umar. "Radiotherapy Beamline Design for Laser-driven Proton Beams." 2019. https://hzdr.qucosa.de/id/qucosa%3A35230.

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Motivation: Radiotherapy is an important modality in cancer treatment commonly using photon beams from compact electron linear accelerators. However, due to the inverse depth dose profile (Bragg peak) with maximum dose deposition at the end of their path, proton beams allow a dose escalation within the target volume and reduction in surrounding normal tissue. Up to 20% of all radiotherapy patients could benefit from proton therapy (PT). Conventional accelerators are utilized to obtain proton beams with therapeutic energies of 70 – 250 MeV. These beams are then transported to the patient via ma

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