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Journal articles on the topic 'Protose'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Trivedi, Mahendra Kumar, Alice Branton, Dahryn Trivedi, Gopal Nayak, Khemraj Bairwa, and Snehasis Jana. "Physicochemical and Spectroscopic Properties of Biofield Energy Treated Protose." American Journal of Biomedical and Life Sciences 3, no. 6 (2015): 104–10. https://doi.org/10.11648/j.ajbls.20150306.11.

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Protose is the enzyme digest of mixed proteins that is recommended for culture media, bulk production of enzymes, antibiotics, toxins, veterinary preparations, etc. This study was proposed to evaluate the effect of biofield energy treatment on the physicochemical and spectroscopic properties of protose. The study was achieved in two groups i.e. control and treated. The control group was remained as untreated, while the treated group was received Mr. Trivedi’s biofield energy treatment. Finally, both the control and treated samples were evaluated using various analytical techniques. The X

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Trivedi, Mahendra Kumar, Alice Branton, Dahryn Trivedi, Gopal Nayak, Khemraj Bairwa, and Snehasis Jana. "Physicochemical and Spectroscopic Properties of Biofield Energy Treated Protose." American Journal of Biomedical and Life Sciences 3, no. 6 (2015): 104–10. https://doi.org/10.5281/zenodo.192201.

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Protose is the enzyme digest of mixed proteins that is recommended for culture media, bulk production of enzymes, antibiotics, toxins, veterinary preparations, etc. This study was proposed to evaluate the effect of biofield energy treatment on the physicochemical and spectroscopic properties of protose. The study was achieved in two groups i.e. control and treated. The control group was remained as untreated, while the treated group was received Mr. Trivedi’s biofield energy treatment. Finally, both the control and treated samples were evaluated using various analytical techniques. The X

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3

Kumar Trivedi, Mahendra. "Physicochemical and Spectroscopic Properties of Biofield Energy Treated Protose." American Journal of Biomedical and Life Sciences 3, no. 6 (2015): 104. http://dx.doi.org/10.11648/j.ajbls.20150306.11.

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4

V, BUGERO, ILYINA A, and ALEXANDROVA M. "Laboratory Model of Molecular-Genetic Interactions of the Protose Blastocystis Spp. With Bacteria Enterococcus Faecalis." Journal of Complementary Medicine Research 12, no. 4 (2021): 55. http://dx.doi.org/10.5455/jcmr.2021.12.04.08.

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5

Christensen, Ove. "Fra protest til protese!" Slagmark - Tidsskrift for idéhistorie, no. 16 (February 1, 2018): 104–7. http://dx.doi.org/10.7146/sl.v0i16.103613.

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Protasi, Feliciano. "Structural interaction between RYRs and DHPRs in calcium release units of cardiac and skeletal muscle cells." Frontiers in Bioscience 7, no. 1-3 (2002): d650. http://dx.doi.org/10.2741/protasi.

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Santamaria, Salvatore. "Novel Approaches for Targeting Metalloproteinases." Pharmaceuticals 16, no. 12 (2023): 1637. http://dx.doi.org/10.3390/ph16121637.

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8

Ozols, Matiss, Alexander Eckersley, Christopher I. Platt, et al. "Predicting Proteolysis in Complex Proteomes Using Deep Learning." International Journal of Molecular Sciences 22, no. 6 (2021): 3071. http://dx.doi.org/10.3390/ijms22063071.

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Both protease- and reactive oxygen species (ROS)-mediated proteolysis are thought to be key effectors of tissue remodeling. We have previously shown that comparison of amino acid composition can predict the differential susceptibilities of proteins to photo-oxidation. However, predicting protein susceptibility to endogenous proteases remains challenging. Here, we aim to develop bioinformatics tools to (i) predict cleavage site locations (and hence putative protein susceptibilities) and (ii) compare the predicted vulnerabilities of skin proteins to protease- and ROS-mediated proteolysis. The fi

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Thomadaki, K., E. J. Helmerhorst, N. Tian, et al. "Whole-saliva Proteolysis and Its Impact on Salivary Diagnostics." Journal of Dental Research 90, no. 11 (2011): 1325–30. http://dx.doi.org/10.1177/0022034511420721.

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There is growing interest in the use of human whole saliva for diagnostics and disease monitoring as an alternative to blood samples. In contrast to blood, whole saliva is a non-sterile body fluid. Proper hand-ling and storage are required to preserve the integrity of potential biomarkers. We investigated salivary autoproteolytic degradation using a variety of approaches. We determined inhibition of protease activities by monitoring the endogenous proteome. In addition, the stability of highly protease-susceptible proteins—histatin 5, statherin, and PRP1—was assessed. Experimental variables in

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Minon, Sophie. "Emplois et valeurs de l'optatif dans le dialecte éléen." Verbum 23, no. 3 (2001): 297–322. https://doi.org/10.3406/verbu.2001.1687.

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L’éléen se singularise par un emploi particulier des modes : les prescriptions y prennent la forme de systèmes hypothétiques, avec protase à l’optatif (autres dialectes : généralement subj. + particule) et apodose à l’opt. + particule (autres dialectes : futur, impér. ou inf. ) ; l’opt. se rencontre également en éléen dans des subordonnées relatives. Il s’agit là, non d’une indifférenciation précoce entre opt. et subj. (protase) ni d’un *optatif prescriptif qui serait hérité (apodose), mais d’un procédé énonciatif délibéré, artifice rhétorique proche de la litote, visant à présenter une obliga

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Impens, Francis, Evy Timmerman, An Staes, et al. "A catalogue of putative HIV-1 protease host cell substrates." Biological Chemistry 393, no. 9 (2012): 915–31. http://dx.doi.org/10.1515/hsz-2012-0168.

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Abstract Processing of human immunodeficiency virus (HIV) proteins by the HIV-1 protease is essential for HIV infectivity. In addition, several studies have revealed cleavage of human proteins by this viral protease during infection; however, no large-scale HIV-1 protease degradomics study has yet been performed. To identify putative host substrates in an unbiased manner and on a proteome-wide scale, we used positional proteomics to identify peptides reporting protein processing by the HIV-1 protease, and a catalogue of over 120 cellular HIV-1 protease substrates processed in vitro was generat

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12

Zhou, Jie, Shantao Li, Kevin K. Leung, et al. "Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries." Proceedings of the National Academy of Sciences 117, no. 41 (2020): 25464–75. http://dx.doi.org/10.1073/pnas.2009279117.

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Proteolysis is a major posttranslational regulator of biology inside and outside of cells. Broad identification of optimal cleavage sites and natural substrates of proteases is critical for drug discovery and to understand protease biology. Here, we present a method that employs two genetically encoded substrate phage display libraries coupled with next generation sequencing (SPD-NGS) that allows up to 10,000-fold deeper sequence coverage of the typical six- to eight-residue protease cleavage sites compared to state-of-the-art synthetic peptide libraries or proteomics. We applied SPD-NGS to tw

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13

Subagiyo, Subagiyo, Muhammad Salauddin Ramadhan Djarod, and Wilis Ari Setyati. "Potensi Ekosistem Mangrove Sebagai Sumber Bakteri Untuk Produksi Protease, Amilase Dan Selulase." Jurnal Kelautan Tropis 20, no. 2 (2017): 106. http://dx.doi.org/10.14710/jkt.v20i2.1703.

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The mangrove ecosystem is a productive ecosystem. The production and accumulation of organic matter on the floor of the mangrove ecosystem allows this region to be rich in microbials that are potential to be developed as a source of a wide range of extra cellular enzymes. In this research, bacteria were isolated and used as the source of enzyme. The bacteria were isolated from the existing mangrove sediments on the north coast of Semarang, Central Java. The bacterial potential as a source of protease, amylase and cellulase is done semiquantitatively using well diffusion agar method. The result

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14

Teune, Simon. "Wo fängt Gewalt an?" Forschungsjournal Soziale Bewegungen 31, no. 1-2 (2018): 214–25. http://dx.doi.org/10.1515/fjsb-2018-0025.

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Zusammenfassung Wie Gewalt im Kontext von Protesten wahrgenommen wird, was als Gewalt gilt und was als legitimer Protest, hängt wesentlich von der Berichterstattung in kommerziellen und öffentlich-rechtlichen Massenmedien ab. Am Beispiel von drei Ereignissen im Kontext der Proteste gegen den G8-Gipfel 2007 in Heiligendamm vergleicht der Beitrag Deutungsmuster und Bildsprache in sechs deutschen Tageszeitungen. Dabei zeigen sich deutliche Unterschiede zwischen liberalen und konservativen Blättern – in der Beurteilung der Ereignisse, in der Perspektivität der Berichterstattung und damit in dem Bi

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McFarlane, Lewis O., and Tara L. Pukala. "Proteomic Investigation of Cape Cobra (Naja nivea) Venom Reveals First Evidence of Quaternary Protein Structures." Toxins 16, no. 2 (2024): 63. http://dx.doi.org/10.3390/toxins16020063.

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Naja nivea (N. nivea) is classed as a category one snake by the World Health Organization since its envenomation causes high levels of mortality and disability annually. Despite this, there has been little research into the venom composition of N. nivea, with only one full venom proteome published to date. Our current study separated N. nivea venom using size exclusion chromatography before utilizing a traditional bottom-up proteomics approach to unravel the composition of the venom proteome. As expected by its clinical presentation, N. nivea venom was found to consist mainly of neurotoxins, w

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Kudzhaev, A. M., A. G. Andrianova, E. S. Dubovtseva, O. V. Serova та T. V. Rotanova. "Role of the Inserted α-Helical Domain in E. coli ATP-Dependent Lon Protease Function". Acta Naturae 9, № 2 (2017): 75–81. http://dx.doi.org/10.32607/20758251-2017-9-2-75-81.

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Multidomain ATP-dependent Lon protease of E. coli (Ec-Lon) is one of the key enzymes of the quality control system of the cellular proteome. A recombinant form of Ec-Lon with deletion of the inserted characteristic -helical HI(CC) domain (Lon-dHI(CC)) has been prepared and investigated to understand the role of this domain. A comparative study of the ATPase, proteolytic, and peptidase activities of the intact Lon protease and Lon-dHI(CC) has been carried out. The ability of the enzymes to undergo autolysis and their ability to bind DNA have been studied as well. It has been shown that the HI(C

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17

Leinius, Johanna. "Zeitgenössische Proteste im Spiegel der gesellschaftstheoretisch motivierten Protest- und Bewegungsforschung." Soziologische Revue 43, no. 2 (2020): 168–84. http://dx.doi.org/10.1515/srsr-2020-0025.

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18

Stehling, Miriam. ""#notheidisgirl, weil ..."." merz | medien + erziehung 62, no. 3 (2018): 31–37. https://doi.org/10.21240/merz/2018.3.12.

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Der Beitrag befasst sich mit digitalen Protest-Artikulationen am Beispiel der Kampagne, die unter dem Hashtag #notheidisgirl geführt wurde und die sich gegen die Castingshow Germany’s next Topmodel richtet. Es wird gezeigt, dass Rezipierende die Sendung als transmedialen Ort zur kritischen Aushandlung von Schönheitsidealen und Körpernormen nutzen und dass feministische Hashtag-Proteste gesellschaftliche Debatten über diese Themen anregen können.

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19

Vögtle, F. Nora. "Mitochondrien unter Stress: Die Rolle der Präsequenzprotease MPP." BIOspektrum 27, no. 4 (2021): 390–93. http://dx.doi.org/10.1007/s12268-021-1589-1.

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AbstractThe majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, the mitochondrial presequence protease MPP serves as example to illustrate the critical role of mitochondrial protein biogenesis and proteostasis on cellular integrity.

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20

Stewart-McGuinness, Callum, Christopher I. Platt, Matiss Ozols, Brian Goh, Tamara W. Griffiths, and Michael J. Sherratt. "Defining the Protease and Protease Inhibitor (P/PI) Proteomes of Healthy and Diseased Human Skin by Modified Systematic Review." Biomolecules 12, no. 3 (2022): 475. http://dx.doi.org/10.3390/biom12030475.

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Proteases and protease inhibitors (P/PIs) are involved in many biological processes in human skin, yet often only specific families or related groups of P/PIs are investigated. Proteomics approaches, such as mass spectrometry, can define proteome signatures (including P/PIs) in tissues; however, they struggle to detect low-abundance proteins. To overcome these issues, we aimed to produce a comprehensive proteome of all P/PIs present in normal and diseased human skin, in vivo, by carrying out a modified systematic review using a list of P/PIs from MEROPS and combining this with key search terms

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21

Schilling, Oliver, and Christopher M. Overall. "Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites." Nature Biotechnology 26, no. 6 (2008): 685–94. http://dx.doi.org/10.1038/nbt1408.

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22

Soh, Wai Tuck, Fatih Demir, Elfriede Dall, et al. "ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease." Analytical Chemistry 92, no. 4 (2020): 2961–71. http://dx.doi.org/10.1021/acs.analchem.9b03604.

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23

Gonczarowska-Jorge, Humberto, Stefan Loroch, Margherita Dell’Aica, Albert Sickmann, Andreas Roos, and René P. Zahedi. "Quantifying Missing (Phospho)Proteome Regions with the Broad-Specificity Protease Subtilisin." Analytical Chemistry 89, no. 24 (2017): 13137–45. http://dx.doi.org/10.1021/acs.analchem.7b02395.

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24

Costa, Mariana I., Micaela Cerletti, Roberto A. Paggi, et al. "Haloferax volcanii Proteome Response to Deletion of a Rhomboid Protease Gene." Journal of Proteome Research 17, no. 3 (2018): 961–77. http://dx.doi.org/10.1021/acs.jproteome.7b00530.

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25

Kim, Hyun-do, and Jong-il Choi. "Medium Optimization and Proteome Analysis of Protease Production by Janthinobacterium sp." Biotechnology and Bioprocess Engineering 25, no. 5 (2020): 787–94. http://dx.doi.org/10.1007/s12257-020-0110-x.

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26

Doctor, Katarina Z., Elizabeth Gilmour, Marilyn Recarte, et al. "Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses." Viruses 15, no. 2 (2023): 542. http://dx.doi.org/10.3390/v15020542.

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Within the viral genome, short stretches of homologous host pathogen sequences (SSHHPS) span the protease cleavage sites. To identify host proteins that may be cleaved during infection, we searched the human proteome for viral protease cleavage sites (~20 amino acids). We developed a sequence-to-symptom tool, automating the search and pairing process. We used the viral protein sequence, PHI-BLAST, and UniProt database for gene ontologies and disease relationships. We applied the tool to nine neuroinvasive viruses: Venezuelan and Eastern Equine encephalitis virus (VEEV, EEEV); severe acute resp

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Stewart, Morgan, Arnaud Quentel, Jose Montoya Mira, et al. "Abstract 1021: Defining total protease activity profiles in pancreatic cancer using a FRET substrate array." Cancer Research 84, no. 6_Supplement (2024): 1021. http://dx.doi.org/10.1158/1538-7445.am2024-1021.

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Abstract Proteases are an important component of many biological processes in the human body, and as such makes them a well-known subject to explore when investigating a variety of disease states from cancer to cardiovascular disease. In all stages of cancer, including early development, proteases play critical roles in almost every aspect for processes such as invasion, promotion of tumor growth, and metastasis. This makes screening of circulating proteases a potentially powerful tool for early detection and prognosis for a variety of cancers. The human proteome, however, is very complex, wit

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Florentin, Anat, Dylon R. Stephens, Carrie F. Brooks, Rodrigo P. Baptista, and Vasant Muralidharan. "Plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the Clp proteolytic system." Proceedings of the National Academy of Sciences 117, no. 24 (2020): 13719–29. http://dx.doi.org/10.1073/pnas.1919501117.

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The human malaria parasite,Plasmodium falciparum, contains an essential plastid called the apicoplast. Most apicoplast proteins are encoded by the nuclear genome and it is unclear how the plastid proteome is regulated. Here, we study an apicoplast-localized caseinolytic-protease (Clp) system and how it regulates organelle proteostasis. Using null and conditional mutants, we demonstrate that theP. falciparumClp protease (PfClpP) has robust enzymatic activity that is essential for apicoplast biogenesis. We developed a CRISPR/Cas9-based system to express catalytically deadPfClpP, which showed tha

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Ohler, Anke, and Christoph Becker-Pauly. "TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections." Biological Chemistry 393, no. 9 (2012): 907–14. http://dx.doi.org/10.1515/hsz-2012-0155.

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Abstract Proteolytic enzymes are involved in almost all biological processes reflecting their importance in health and disease. The human genome contains nearly 600 protease-encoding genes forming more than 2% of the total human proteome. The serine proteases, with about 180 members, built the oldest and second largest family of human proteases. Ten years ago, a novel serine protease family named the type II transmembrane family (TTSP) was identified. This minireview summarizes the up-to-date knowledge about the still growing TTSPs, particularly focusing on the pathophysiological functions of

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30

Elwakiel, Mohèb, Sjef Boeren, Jos Hageman, Ignatius Szeto, Henk Schols, and Kasper Hettinga. "Variability of Serum Proteins in Chinese and Dutch Human Milk during Lactation." Nutrients 11, no. 3 (2019): 499. http://dx.doi.org/10.3390/nu11030499.

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To better understand the variability of the type and level of serum proteins in human milk, the milk serum proteome of Chinese mothers during lactation was investigated using proteomic techniques and compared to the milk serum proteome of Dutch mothers. This showed that total milk serum protein concentrations in Chinese human milk decreased over a 20-week lactation period, although with variation between mothers in the rate of decrease. Variation was also found in the composition of serum proteins in both colostrum and mature milk, although immune-active proteins, enzymes, and transport protei

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Wang, Chao, Shiqiang Yu, Ting Song, Tingting He, Huanhuan Shao, and Haiyan Wang. "Extracellular Proteome Profiling of Bacillus pumilus SCU11 Producing Alkaline Protease for Dehairing." Journal of Microbiology and Biotechnology 26, no. 11 (2016): 1993–2005. http://dx.doi.org/10.4014/jmb.1602.02042.

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32

Sommer, Moritz, Sabrina Zajak, and Sebastian Haunss. "„Der Kontext lokaler Proteste“ – Jahrestagung des Instituts für Protest- und Bewegungsforschung 2018." Forschungsjournal Soziale Bewegungen 32, no. 1 (2019): 88–93. http://dx.doi.org/10.1515/fjsb-2019-0011.

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Hamon, Marie-Paule, Aurélien Bayot, Monique Gareil, et al. "Effects of Lon protease down-regulation on the mitochondrial function and proteome." Free Radical Biology and Medicine 75 (October 2014): S32—S33. http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.767.

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34

Thesbjerg, Martin Nørmark, Søren Drud-Heydary Nielsen, Ulrik Kræmer Sundekilde, Nina Aagaard Poulsen, and Lotte Bach Larsen. "Fingerprinting of Proteases, Protease Inhibitors and Indigenous Peptides in Human Milk." Nutrients 15, no. 19 (2023): 4169. http://dx.doi.org/10.3390/nu15194169.

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The presence of proteases and their resulting level of activity on human milk (HM) proteins may aid in the generation of indigenous peptides as part of a pre-digestion process, of which some have potential bioactivity for the infant. The present study investigated the relative abundance of indigenous peptides and their cleavage products in relation to the abundance of observed proteases and protease inhibitors. The proteomes and peptidomes in twelve HM samples, representing six donors at lactation months 1 and 3, were profiled. In the proteome, 39 proteases and 29 protease inhibitors were iden

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Möller, Jens, Svenja Schorlemmer, Jörg Hofmann, and Andreas Burkovski. "Cellular and Extracellular Proteome of the Animal Pathogen Corynebacterium silvaticum, a Close Relative of Zoonotic Corynebacterium ulcerans and Corynebacterium pseudotuberculosis." Proteomes 8, no. 3 (2020): 19. http://dx.doi.org/10.3390/proteomes8030019.

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Corynebacterium silvaticum is a newly described animal pathogen, closely related to the emerging human pathogen Corynebacterium ulcerans and Corynebacterium pseudotuberculosis, a major pathogen of small ruminants. In this study, proteins of a whole cell and a shaving fraction and the exoproteome of C. silvaticum strain W25 were analyzed as a first proteome study of this species. In total, 1305 proteins were identified out of 2013 proteins encoded by the W25 genome sequence and number of putative virulence factors were detected already under standard growth conditions including phospholipase D

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Ohba, Yohsuke, Thomas MacVicar, and Thomas Langer. "Regulation of mitochondrial plasticity by the i-AAA protease YME1L." Biological Chemistry 401, no. 6-7 (2020): 877–90. http://dx.doi.org/10.1515/hsz-2020-0120.

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AbstractMitochondria are multifaceted metabolic organelles and adapt dynamically to various developmental transitions and environmental challenges. The metabolic flexibility of mitochondria is provided by alterations in the mitochondrial proteome and is tightly coupled to changes in the shape of mitochondria. Mitochondrial proteases are emerging as important posttranslational regulators of mitochondrial plasticity. The i-AAA protease YME1L, an ATP-dependent proteolytic complex in the mitochondrial inner membrane, coordinates mitochondrial biogenesis and dynamics with the metabolic output of mi

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Nishimura, Kenji, Reiko Nakagawa, Chisato Hachisuga, and Yuri Nakajima Munekage. "Deciphering the Proteotoxic Stress Responses Triggered by the Perturbed Thylakoid Proteostasis in Arabidopsis." Plants 10, no. 3 (2021): 519. http://dx.doi.org/10.3390/plants10030519.

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Here, we explored heat dependent thylakoid FtsH protease substrates and investigated proteotoxicity induced by thermal damage and processive protease dysfunction on the thylakoid membrane. Through our thylakoid enriched proteome analysis and biochemical experiments, carbonylated stromal proteins were suggested as possible FtsH targets. Furthermore, we observed in the thylakoid fractions in the absence of FtsH stromal reactive oxygen species-detoxifying enzymes, as well as heat shock proteins and chaperones, which are known to be upregulated at the transcriptional level when this protease is ab

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Pinski, Artur, Alexander Betekhtin, Bozena Skupien-Rabian, Urszula Jankowska, Elisabeth Jamet, and Robert Hasterok. "Changes in the Cell Wall Proteome of Leaves in Response to High Temperature Stress in Brachypodium distachyon." International Journal of Molecular Sciences 22, no. 13 (2021): 6750. http://dx.doi.org/10.3390/ijms22136750.

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High temperature stress leads to complex changes to plant functionality, which affects, i.a., the cell wall structure and the cell wall protein composition. In this study, the qualitative and quantitative changes in the cell wall proteome of Brachypodium distachyon leaves in response to high (40 °C) temperature stress were characterised. Using a proteomic analysis, 1533 non-redundant proteins were identified from which 338 cell wall proteins were distinguished. At a high temperature, we identified 46 differentially abundant proteins, and of these, 4 were over-accumulated and 42 were under-accu

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Franco, Jessica Y., Shree P. Thapa, Zhiqian Pang, et al. "Citrus Vascular Proteomics Highlights the Role of Peroxidases and Serine Proteases during Huanglongbing Disease Progression." Molecular & Cellular Proteomics 19, no. 12 (2020): 1936–51. http://dx.doi.org/10.1074/mcp.ra120.002075.

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Huanglongbing (HLB) is the most devastating and widespread citrus disease. All commercial citrus varieties are susceptible to the HLB-associated bacterium, Candidatus Liberibacter asiaticus (CLas), which resides in the phloem. The phloem is part of the plant vascular system and is involved in sugar transport. To investigate the plant response to CLas, we enriched for proteins surrounding the phloem in an HLB susceptible sweet orange variety, Washington navel (Citrus sinensis (L) Osbeck). Quantitative proteomics revealed global changes in the citrus proteome after CLas inoculation. Plant metabo

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Kim, Dae-Wi, Keith Chater, Kye-Joon Lee, and Andy Hesketh. "Changes in the Extracellular Proteome Caused by the Absence of the bldA Gene Product, a Developmentally Significant tRNA, Reveal a New Target for the Pleiotropic Regulator AdpA in Streptomyces coelicolor." Journal of Bacteriology 187, no. 9 (2005): 2957–66. http://dx.doi.org/10.1128/jb.187.9.2957-2966.2005.

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ABSTRACT The extracellular proteome of Streptomyces coelicolor grown in a liquid medium was analyzed by using two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization-time of flight peptide mass fingerprint analysis. Culture supernatants became protein rich only after rapid growth had been completed, supporting the idea that protein secretion is largely a stationary phase phenomenon. Out of about 600 protein spots observed, 72 were characterized. The products of 47 genes were identified, with only 11 examples predicted to be secreted proteins. Mutation in bldA, previ

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Gordon, Nadria D., Geri L. Ottaviano, Sarah E. Connell та ін. "Secreted-Protein Response to σU Activity in Streptomyces coelicolor". Journal of Bacteriology 190, № 3 (2007): 894–904. http://dx.doi.org/10.1128/jb.01759-07.

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ABSTRACT The filamentous bacterium Streptomyces coelicolor forms an aerial mycelium as a prerequisite to sporulation, which occurs in the aerial hyphae. Uncontrolled activity of the extracytoplasmic function sigma factor σU blocks the process of aerial mycelium formation in this organism. Using a green fluorescent protein transcriptional reporter, we have demonstrated that sigU transcription is autoregulated. We have defined a σU-dependent promoter sequence and used this to identify 22 likely σU regulon members in the S. coelicolor genome. Since many of these genes encode probable secreted pro

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Karlsson, Christofer A. Q., Sofia Järnum, Lena Winstedt, et al. "Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS." Molecular & Cellular Proteomics 17, no. 6 (2018): 1097–111. http://dx.doi.org/10.1074/mcp.ra117.000525.

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Infectious diseases are characterized by a complex interplay between host and pathogen, but how these interactions impact the host proteome is unclear. Here we applied a combined mass spectrometry-based proteomics strategy to investigate how the human proteome is transiently modified by the pathogen Streptococcus pyogenes, with a particular focus on bacterial cleavage of IgG in vivo. In invasive diseases, S. pyogenes evokes a massive host response in blood, whereas superficial diseases are characterized by a local leakage of several blood plasma proteins at the site of infection including IgG.

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Marchesini, María Inés, Ansgar Poetsch, Leticia Soledad Guidolín, and Diego J. Comerci. "Brucella abortus Encodes an Active Rhomboid Protease: Proteome Response after Rhomboid Gene Deletion." Microorganisms 10, no. 1 (2022): 114. http://dx.doi.org/10.3390/microorganisms10010114.

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Rhomboids are intramembrane serine proteases highly conserved in the three domains of life. Their key roles in eukaryotes are well understood but their contribution to bacterial physiology is still poorly characterized. Here we demonstrate that Brucella abortus, the etiological agent of the zoonosis called brucellosis, encodes an active rhomboid protease capable of cleaving model heterologous substrates like Drosophila melanogaster Gurken and Providencia stuartii TatA. To address the impact of rhomboid deletion on B. abortus physiology, the proteomes of mutant and parental strains were compare

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Biniossek, Martin L., Melanie Niemer, Ken Maksimchuk, et al. "Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics." Molecular & Cellular Proteomics 15, no. 7 (2016): 2515–24. http://dx.doi.org/10.1074/mcp.o115.056671.

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Tangsongcharoen, Chontida, Sittiruk Roytrakul, and Duncan R. Smith. "Analysis of cellular proteome changes in response to ZIKV NS2B-NS3 protease expression." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1867, no. 2 (2019): 89–97. http://dx.doi.org/10.1016/j.bbapap.2018.10.016.

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Román-Meléndez, Gabriel D., Thiagarajan Venkataraman, Daniel R. Monaco, and H. Benjamin Larman. "Protease Activity Profiling via Programmable Phage Display of Comprehensive Proteome-Scale Peptide Libraries." Cell Systems 11, no. 4 (2020): 375–81. http://dx.doi.org/10.1016/j.cels.2020.08.013.

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Andrianova, A. G., A. M. Kudzhaev, V. A. Abrikosova, A. E. Gustchina, I. V. Smirnov, and T. V. Rotanova. "Involvement of the N Domain Residues E34, K35, and R38 in the Functionally Active Structure of Escherichia coli Lon Protease." Acta Naturae 12, no. 4 (2020): 86–97. http://dx.doi.org/10.32607/actanaturae.11197.

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ATP-dependent Lon protease of Escherichia coli (EcLon), which belongs to the superfamily of AAA+ proteins, is a key component of the cellular proteome quality control system. It is responsible for the cleavage of mutant, damaged, and short-lived regulatory proteins that are potentially dangerous for the cell. EcLon functions as a homooligomer whose subunits contain a central characteristic AAA+ module, a C-terminal protease domain, and an N-terminal non-catalytic region composed of the actual N-terminal domain and the inserted -helical domain. An analysis of the N domain crystal structure sugg

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Furukawa, Atsushi, Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki. "Cysteine Protease-Binding Protein Family 6 Mediates the Trafficking of Amylases to Phagosomes in the Enteric Protozoan Entamoeba histolytica." Infection and Immunity 81, no. 5 (2013): 1820–29. http://dx.doi.org/10.1128/iai.00915-12.

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ABSTRACTPhagocytosis plays a pivotal role in nutrient acquisition and evasion from the host defense systems inEntamoeba histolytica, the intestinal protozoan parasite that causes amoebiasis. We previously reported thatE. histolyticapossesses a unique class of a hydrolase receptor family, designated the cysteine protease-binding protein family (CPBF), that is involved in trafficking of hydrolases to lysosomes and phagosomes, and we have also reported that CPBF1 and CPBF8 bind to cysteine proteases or β-hexosaminidase α-subunit and lysozymes, respectively. In this study, we showed by immunopreci

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Frieman, Matthew, Kiira Ratia, Robert E. Johnston, Andrew D. Mesecar та Ralph S. Baric. "Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling". Journal of Virology 83, № 13 (2009): 6689–705. http://dx.doi.org/10.1128/jvi.02220-08.

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ABSTRACT The outcome of a viral infection is regulated in part by the complex coordination of viral and host interactions that compete for the control and optimization of virus replication. Severe acute respiratory syndrome coronavirus (SARS-CoV) intimately engages and regulates the host innate immune responses during infection. Using a novel interferon (IFN) antagonism screen, we show that the SARS-CoV proteome contains several replicase, structural, and accessory proteins that antagonize the IFN pathway. In this study, we focus on the SARS-CoV papain-like protease (PLP), which engages and an

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Kalatskaja, Joanna N., Natallia V. Baliuk, Katsiaryna I. Rybinskaya, et al. "Increasing Potato Sustainability to PVY under Water Deficiency by Bacillus Bacteria with Salicylic Acid and Methyl Jasmonate." International Journal of Plant Biology 14, no. 1 (2023): 312–28. http://dx.doi.org/10.3390/ijpb14010026.

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The protective effect of Bacillus bacteria against viruses can be significantly expanded by combination with salicylic acid (SA) or methyl jasmonate (MeJ). In soil water deficiency conditions, potato leaves were sprayed with Bacillus subtilis strain 47 combined with MeJ and MeJ + SA displayed a decrease in PVY and preservation of the shoot’s growth. Signaling molecules with Bacillus subtilis mitigated the adverse effect of PVY under water deficiency by manipulating enzymatic/non-enzymatic antioxidant levels and activity in treated plants. The application mixtures increased the mass and number

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