Relevant bibliographies by topics / Proximal interactomics

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Proximal interactomics'

Author: Grafiati
Published: 15 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Proximal interactomics"

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Sofianatos, Yorgos, Étienne Coyaud, and Caroline Demeret. "Towards a three-dimensional mapping of virus-host proximal protein interactions." Project Repository Journal 13, no. 1 (2022): 14–17. http://dx.doi.org/10.54050/prj1318790.

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Towards a three-dimensional mapping of virus-host proximal protein interactions The SARS-CoV-2 proximal interactome project sets out to build a comprehensive, three-dimensional map of protein virus-host protein interactions inside living human cells. It aims to shed light on unknown mechanisms of infection. It is made possible by a combination of advanced interactomics techniques coupled with algorithms for the 3D visualisation of networks.
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Harris, C. Jake, Marion Scheibe, Somsakul Pop Wongpalee, et al. "A DNA methylation reader complex that enhances gene transcription." Science 362, no. 6419 (2018): 1182–86. http://dx.doi.org/10.1126/science.aar7854.

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DNA methylation generally functions as a repressive transcriptional signal, but it is also known to activate gene expression. In either case, the downstream factors remain largely unknown. By using comparative interactomics, we isolated proteins in Arabidopsis thaliana that associate with methylated DNA. Two SU(VAR)3-9 homologs, the transcriptional antisilencing factor SUVH1, and SUVH3, were among the methyl reader candidates. SUVH1 and SUVH3 bound methylated DNA in vitro, were associated with euchromatic methylation in vivo, and formed a complex with two DNAJ domain-containing homologs, DNAJ1
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Haider, Nasir A., Joanna Kelly, Duncan Smith, and Claus Jorgensen. "Abstract A099: Utilising interactomics to uncover oncogenic KRAS signalling networks in the context of the tumor microenvironment." Cancer Research 84, no. 2_Supplement (2024): A099. http://dx.doi.org/10.1158/1538-7445.panca2023-a099.

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Abstract Extensive genetic analyses of Pancreatic Ductal Adenocarcinoma (PDAC) tumors have identified the GTPase KRAS as a major driver of tumorigenesis, with over 90% of tumors possessing oncogenic KRAS mutations, primarily at the mutational hotspot G12. KRAS G12 mutants are constitutively active, and promote cancer growth by hyperdriving multiple downstream effector pathways via direct physical interactions with proteins such as PI3K and RAF. Despite KRASG12Mut being a promising drug target, direct targeting of KRASG12Mut or downstream pathways has shown limited success, with the emergence o
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Chua, Xien Yu, Timothy Aballo, William Elnemer, Melanie Tran, and Arthur Salomon. "Quantitative Interactomics of Lck-TurboID in Living Human T Cells Unveils T Cell Receptor Stimulation-Induced Proximal Lck Interactors." Journal of Proteome Research 20, no. 1 (2020): 715–26. http://dx.doi.org/10.1021/acs.jproteome.0c00616.

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Scandore, Cody, Kendall Johnson, Chris May, et al. "Abstract 4244: Application of a membrane interactomics (MInt) platform for novel surface target discovery." Cancer Research 85, no. 8_Supplement_1 (2025): 4244. https://doi.org/10.1158/1538-7445.am2025-4244.

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Abstract Despite advances in cancer therapeutics, there remains a critical need to identify new protein targets and targeting approaches for drug development, particularly those with improved efficacy and safety profiles. To address these challenges, InduPro leverages a high-resolution proximity proteomics technology that uses photocatalyst-generated reactive probes to label cell surface protein microenvironments (1, 2). Combining this technology with quantitative mass spectrometry, we achieve high-throughput characterization of the plasma membrane protein interactome at an unprecedented detai
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Malone, Clare F., Anna de Regt, Chris May, et al. "Abstract 4255: Membrane interactomics (MInt) platform identifies EGFR and CDCP1 as effective co-targets for bispecific antibody drug conjugate IDP-001." Cancer Research 85, no. 8_Supplement_1 (2025): 4255. https://doi.org/10.1158/1538-7445.am2025-4255.

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EGFR is a biologically validated target which is overexpressed and activated in many human cancers and associated with poor prognosis. However, most current EGFR targeting therapies encompassing multiple modalities have shown limited therapeutic efficacy, frequently due to on-target toxicity in non-malignant tissues where EGFR is expressed. To improve selectivity via co-localization targeting over co-expression alone, we utilized InduPro’s proprietary MInt platform across multiple cancer cell systems to identify CDCP1 as a tumor associated proximity antigen to EGFR on tumor cells. Like EGFR, C
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Ibarz, Antoni, Ignasi Sanahuja, Waldo G. Nuez-Ortín, Laura Martínez-Rubio, and Laura Fernández-Alacid. "Physiological Benefits of Dietary Lysophospholipid Supplementation in a Marine Fish Model: Deep Analyses of Modes of Action." Animals 13, no. 8 (2023): 1381. http://dx.doi.org/10.3390/ani13081381.

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Given the hydrophilic structure of lysophospholipids (LPLs), their dietary inclusion translates into a better emulsifying capacity of the dietary components. The present study aimed to understand the mechanisms underlying the growth-promoting effect of LPL supplementation by undertaking deep analyses of the proximal intestine and liver interactomes. The Atlantic salmon (Salmo salar) was selected as the main aquaculture species model. The animals were divided into two groups: one was fed a control diet (C-diet) and the other a feed (LPL-diet) supplemented with an LPL-based digestive enhancer (0
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Kumar, Mukesh, Kanchan Singh, Jayant Joshi, et al. "Mechanistic insights into Alpha-Synuclein binding to P2RX7: A molecular dynamic and docking study." PLOS One 20, no. 5 (2025): e0319098. https://doi.org/10.1371/journal.pone.0319098.

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Alpha-synucleinopathies, characterized by extracellular alpha-synuclein (αSyn or SNCA) accumulation and aggregation, have been linked to neurological disorders including Parkinson’s disease and multiple system atrophy. P2RX7 is a non-selective cationic transmembrane purinergic receptor activated by elevated levels of extracellular ATP, which typically occurs during inflammatory conditions. Activation of P2RX7 by αSyn is implicated in neuronal degeneration, potentially causing pore dilation and increased inflammation. By integrating the data curation, molecular docking, and molecular dynamics (
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Osagie, Oloruntoba I., Jordann Smakk, Deborah E. Citrin, and Travis H. Stracker. "Abstract 4802: Identification of critical hypoxia induced factors in castrate resistant prostate cancer." Cancer Research 83, no. 7_Supplement (2023): 4802. http://dx.doi.org/10.1158/1538-7445.am2023-4802.

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Abstract Background: Prostate cancer (PCa) is the second most diagnosed cancer in men and the second cause of cancer-related death amongst men worldwide. PCa is a heterogeneous disease, and the outcome is worse for patients when the disease progresses from localized PCa to a castrate-resistant disease. Androgen receptor (AR) signaling is crucial for PCa development and has been a major therapeutic target for decades. Despite the success made with hormone therapy to block AR signaling, castration resistant disease can arise through mutations and amplifications of the androgen receptor (AR) and
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Cutler, Jevon, Rahia Tahir, Jingnan Han, et al. "Differential Signaling through p190 and p210 Forms of BCR-ABL Fusion Proteins Revealed By Proteomic Analysis." Blood 126, no. 23 (2015): 3651. http://dx.doi.org/10.1182/blood.v126.23.3651.3651.

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Abstract Chromosomal translocations involving chromosome 9q34 and 22q11 generate the BCR-ABL1 fusion gene. The location of the translocation within the BCR gene dictates which exons are excluded or included in the resulting fusion with the ABL1 gene. The most common translocations produce three main protein products with molecular weights of 190, 210, and 230 kD. Interestingly, the p190 and p210 BCR-ABL1 forms are associated with different clinical characteristics. Specifically, BCR-ABL1+ acute lymphoblastic leukemia (ALL) cases typically harbor the p190 form, whereas chronic myelogenous leuke
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Dissertations / Theses on the topic "Proximal interactomics"

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Bachiri, Kamel. "Identification des interactions oncogéniques du Polyomavirus à cellules de Merkel." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS113.

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Le carcinome à cellules de Merkel (CCM) est un cancer de la peau agressif et de très mauvais pronostic. Ce cancer est lié à la présence du Polyomavirus à cellules de Merkel dans 80% des cas. Ce Polyomavirus exprime deux oncoprotéines virales : sT et LT tronquée. L'expression des deux antigènes T est suffisante à l'émergence du cancer et responsable de la perturbation de checkpoints de signalisation, de la modification du profil épigénétique et de l'évasion immunitaire. L'interactomique et la protéomique nous ont permis d'identifier de nombreux facteurs épigénétiques en relation avec les antigè
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