Log in

Relevant bibliographies by topics / Proximal renal tubules / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Proximal renal tubules.

Dissertations / Theses on the topic 'Proximal renal tubules'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Proximal renal tubules.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

SILBER, PAUL MICHAEL. "EARLY INDICATION AND PATHOGENESIS OF RENAL PROXIMAL TUBULE INJURY (ENZYMURIA)." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184097.

Full text

Abstract:

It is well known that a variety of toxicants can cause damage to the renal proximal tubule. However, the early pathogenesis of these deleterious interactions between a toxicant and this region of the nephron remain poorly understood. Thus, the purpose of this research was to attempt to answer three interrelated questions. First, what are the earliest changes in kidney function and structure after administration of tubule toxicants in vivo? Secondly, how do these structural/functional alterations change over time? Finally, are certain indicators of renal "dysfunction" more sensitive then other

APA, Harvard, Vancouver, ISO, and other styles

2

Shuprisha, Apichai. "Real-time assessment of organic anion secretion in isolated, perfused rabbit renal proximal tubules." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/289029.

Full text

Abstract:

A newly developed epifluorescense microscopy system has been employed to measure net transepithelial secretion of fluorescein (FL) in real time in isolated perfused S2 segments of rabbit renal proximal tubules. Net FL secretion (K(t), ∼4 μM, and J(max), ∼280 fmol·min⁻¹·mm⁻¹) shares the same transport system with that of para -aminohippurate (PAH). The basolateral Na-DC cotransporter supports ∼25% of the "basal" FL secretion in the absence of exogenous αKG via recycling of αKG that has been exchanged for FL. Physiological αKG concentrations in the bath (∼10 μM) or in the perfusate (∼50 μM) stim

APA, Harvard, Vancouver, ISO, and other styles

3

RUEGG, CHARLES EDWARD. "MECHANISMS UNDERLYING REGIOSELECTIVE ACUTE TUBULAR NECROSIS OF RENAL PROXIMAL TUBULAR SEGMENTS." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184162.

Full text

Abstract:

The convoluted (CPT) and straight (SPT) portions of the renal proximal tubule are susceptible to injury by a wide variety of chemical agents. These agents often affect the CPT or SPT selectively by proposed mechanisms usually attributed to tubular concentration, blood flow delivery patterns and tubuloglomerular feedback responses within the intact kidney. The innate cellular responses to chemical exposures remain virtually unexplored. Hence, the basic goal of this research was to develop an in vitro system that was conducive to examining the innate cellular differences in susceptibility betwee

APA, Harvard, Vancouver, ISO, and other styles

4

Tang, Chi-wai Sydney. "The many facets of the renal proximal tubular epithelial cell in human." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31992468.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Tang, Chi-wai Sydney, and 鄧智偉. "The many facets of the renal proximal tubular epithelial cell inhuman." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31992468.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Reece, Mark T. "Functional characterization of OCTRL2 : an organic cation transporter expressed in the renal proximal tubules." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20973.

Full text

Abstract:

Chromosome 11p15.5 harbors a gene or genes involved in Beckwith Wiedemann Syndrome (BWS) and that confer(s) susceptibility to Wilms' tumor, rhabdomyosarcoma, and hepatoblastoma. PowerBLAST of P1 artificial chromosome clones from this region identified two novel transcripts with open reading frames encoding putative proteins of 253 and 424 amino acids. The larger of the transcripts was shown by Northern blot to be predominantly expressed in the fetal and adult liver and kidney. This transcript shares homology with integral membrane organic cation transporters, such as the tetracycline resistanc

APA, Harvard, Vancouver, ISO, and other styles

7

Branco, Regiane Cardoso Castelo. "Efeito da angiotensina-(1-7) no fluxo reabsortivo de bicarbonato (JHCO3-) e na concentração citosólica de cálcio ([Ca2+]i): estudo por microperfusão tubular proximal, in vivo." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-25072012-135726/.

Full text

Abstract:

O estudo avaliou os efeitos agudos da Ang-(1-7) na reabsorção de bicarbonato (JHCO3-) no túbulo proximal cortical de rato, in vivo, medindo o pH intratubular pelo microeletródio sensível a H+. O JHCO3- controle é 2,84 ± 0,08 nmol. cm-2. s-1 (49), a Ang-(1-7; 10-12 ou 10-9 M) o reduz (35 ou 61 %) e a Ang-(1-7; 10-6 M) o eleva (56 %). A inibição do receptor Mas (por A779) eleva o JHCO3- (30 %), abole o efeito inibidor da Ang-(1-7), mas não afeta seu efeito estimulador. A inibição do NHE3 (por S3226) diminui o JHCO3- (45 %), não altera o efeito inibidor da Ang-(1-7), mas transforma seu efeito est

APA, Harvard, Vancouver, ISO, and other styles

8

Pergher, Patrícia e. Silva. "Efeitos não-genômicos dos hormônios esteróides - aldosterona e corticosterona - sobre a acidificação do túbulo proximal (S2) de ratos: estudos de microperfusão tubular e capilar, in vivo." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-10122010-144456/.

Full text

Abstract:

O objetivo foi determinar se aldosterona e corticosterona agem sobre a acidificação do túbulo proximal e se esses efeitos são genômicos e/ou não-genômicos. A reabsorção de HCO3- foi avaliada por microperfusão estacionária. Aldosterona e corticosterona perfundidas na luz tubular causaram aumento significante do JHCO3-. Na presença de etanol, actinomicina D, cicloheximida ou espironolactona, o JHCO3- foi estatisticamente igual ao valor controle (2,84 ± 0,079 nmol.cm-2.s-1). RU486 sozinho inibiu o efeito estimulador da aldosterona e corticosterona. Losartan não alterou o JHCO3-. Concanomicina ou

APA, Harvard, Vancouver, ISO, and other styles

9

Farah, Livia Xavier Soares. "Efeito do peptídeo-1 semelhante ao glucagon endógeno sobre a atividade do NHE3 em túbulo proximal renal." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-05102015-114814/.

Full text

Abstract:

O peptídeo-1 semelhante ao glucagon (GLP-1) é um hormônio incretina secretado pelas células L do trato gastrointestinal e liberado imediatamente após a ingestão de alimento. O GLP-1 estimula a secreção de insulina pós-prandial moderando a elevação precoce da glicose no sangue. Embora primariamente envolvido na homeostase da glicose, o GLP-1 é capaz de induzir a diurese e natriurese, quando administrado em doses farmacológicas em humanos e em roedores. Estudos prévios do nosso laboratório demonstraram que o mecanismo de ação renal do GLP-1, bem como de agonistas sintéticos do receptor GLP-1R, e

APA, Harvard, Vancouver, ISO, and other styles

10

Lee, Sarah Angeline. "Curcumin Protects against Renal Ischemia by Activating the Unfolded Protein Response and Inducing HSP70." Yale University, 2009. http://ymtdl.med.yale.edu/theses/available/etd-04062009-215154/.

Full text

Abstract:

The purpose of this study was to establish whether curcumin protects renal proximal tubule cells against ischemic injury, determine whether this postulated cytoprotective effect is mediated through the upregulation of HSP70, and investigate whether the mechanism by which curcumin induces HSP70 expression and confers its protective effect is through activation of the Unfolded Protein Response. LLC-PK1 cells were cultured on collagen-coated filters to mimic conditions of in vivo renal proximal tubule cells and induce cell polarization. Injury with and without curcumin treatment was studied by us

APA, Harvard, Vancouver, ISO, and other styles

11

Kfouri, Flavia. "Papel do p21 e do estresse oxidativo na resistência renal isquêmica." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-11032008-151200/.

Full text

Abstract:

A resistência tubular renal tem sido estudada a fim de se ampliar a compreensão da fisiopatologia da Insuficiência renal aguda (IRA). A isquemia renal induz à resistência a um subseqüente insulto isquêmico sendo que os mecanismos de resistência parecem depender de alterações celulares. O p21 é um inibidor do ciclo celular, o qual pode ser induzido por radicais livres de oxigênio e parece ter um efeito protetor na IRA isquêmica. O objetivo deste estudo é avaliar o papel do p21 e do estresse oxidativo em modelo de resistência adquirida após episódio de IRA isquêmica, e em túbulos proximais isola

APA, Harvard, Vancouver, ISO, and other styles

12

Chen, Ming. "Renal cell death in urinary tract infections : role of E. coli toxins /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-166-0/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Passos, Marta Cristina de Caldas. "Síndrome de Fanconi em cães." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2009. http://hdl.handle.net/10400.5/1134.

Full text

Abstract:

Dissertação de Mestrado Integrado em Medicina Veterinária<br>A síndrome de Fanconi é uma doença renal caracterizada por uma disfunção generalizada dos túbulos renais proximais da qual resultam perdas urinárias excessivas de solutos. Estas perdas vão ser responsáveis pelo desenvolvimento de alterações metabólicas e manifestações clínicas que, no seu conjunto, constituem a síndrome. A gravidade das perdas urinárias dos vários solutos é variável entre os animais afectados, bem como a sua expressão sintomatológica. Trata-se de uma doença rara que foi descrita inicialmente em humanos por Guido

APA, Harvard, Vancouver, ISO, and other styles

14

Crajoinas, Renato de Oliveira. "Regulação diferencial do trocador Na+/H+ NHE3 em túbulo proximal renal antes e após o desenvolvimento da hipertensão arterial." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-12032013-095424/.

Full text

Abstract:

A hipertensão arterial essencial é caracterizada pela elevação crônica da pressão arterial e representa o principal fator de risco para doenças cardiovasculares e renais. O rim participa do controle da pressão arterial e alterações intrínsecas no manuseio renal de sódio desempenham papel importante na patogênese da hipertensão essencial. Os túbulos proximais renais são responsáveis pela reabsorção da maior parte do sódio filtrado nos glomérulos e a maior parte da reabsorção de sódio neste segmento faz-se através da troca de Na+ por H+ em membrana apical, mediada pela isoforma 3 do trocador Na+

APA, Harvard, Vancouver, ISO, and other styles

15

Crajoinas, Renato de Oliveira. "Papel da via receptor AT1/proteina Gi e da proteína motora miosina IIA no aumento da atividade do NHE3 pela angiotensina II em túbulo proximal renal." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-18122017-092553/.

Full text

Abstract:

A isoforma 3 do trocador Na+ /H+ (NHE3), presente em membrana apical, é a proteína de transporte que medeia a maior parte da reabsorção de NaCl e NaHCO3- em túbulo proximal renal. A fosforilação direta do NHE3 por PKA na serina 552 é um dos mecanismos pelos quais a sua atividade pode ser inibida. A ligação da angiotensina II (Ang II) ao receptor AT1 (AT1R) em túbulo proximal estimula a atividade do NHE3 por diferentes vias de sinalização. Entretanto, não foram ainda bem estabelecidos os efeitos da ativação da via AT1R/Gi, com consequente diminuição nos níveis de cAMP, na regulação do NHE3. A A

APA, Harvard, Vancouver, ISO, and other styles

16

Bignon, Yohan. "Physiologie et physiopathologie des transports transépithéliaux du tubule proximal : mise en évidence du rôle de la sous-unité Kir4.2 et analyse d'un mutant de ClC-5 impliqué dans la maladie de Dent." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066244/document.

Full text

Abstract:

Le tubule proximal participe à la diurèse en modifiant la composition de l'ultrafiltrat glomérulaire. Grâce à de nombreux transports transépithéliaux, il le glucose, les acides aminés et les protéines de bas poids moléculaires, ainsi que 80 % des ions HPO42- ou HCO3-, 60 % des ions Na+, Cl-, K+, Ca2+, 75 % de l’eau et 30 % des ions Mg2+ ultrafiltrés.Durant ma thèse, j'ai étudié les rôles physiologiques et physiopathologiques de deux protéines de transport exprimées dans le tubule proximal.Dans le cadre de ma première étude, j'ai évalué in vivo la fonction rénale de souris n'exprimant pas une p

APA, Harvard, Vancouver, ISO, and other styles

17

White, S. J. "Anion transport in the renal proximal tubule of the rat." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376286.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Takaori, Koji. "Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis." Kyoto University, 2018. http://hdl.handle.net/2433/232126.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Timmeren, Mirjan Miranda van. "The proximal tubular cell, a keyplayer in renal damage." [S.l. : Groningen : s.n. ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/306188546.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Griffith, Douglas A. "Nucleoside and nucleobase transport in renal proximal tubular epithelia." Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262374.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Selbi, Wisam Dhafer Rashid. "Regulation and function of hyaluronan in renal proximal tubule epithelial cells." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/54266/.

Full text

Abstract:

v. HA binding proteins (Hyaladherins) differentially affected extracellular HA structures. Inter-alpha-trypsin inhibitor (loci) is important in the formation of HA coats as well as HA cables. Tumour necrosis factor-stimulated gene-6 (TSG-6) is seen to be crucial to the formation of HA coats but not HA cables, while the role of versican in either structures is not fully determined yet although it is thought to be more crucial to the formation of HA cables.

APA, Harvard, Vancouver, ISO, and other styles

22

Marable, Sierra S. "The Role of Hepatocyte Nuclear Factor 4a in Renal Proximal Tubule Development." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595849621045508.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Shah, Nileshkumar. "Expression and regulation of cadherin of human renal proximal tubule epithelial cells." Thesis, St George's, University of London, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.754076.

Full text

Abstract:

Cadherins are a family of trans-membrane junctional proteins important in maintenance of cell-cell junction, phenotype regulation, tissue organisation and embryonic development. The proteins form calcium dependent homophilic cell junctional complexes and bind internally to the actin cytoskeleton and regulate intracellular signalling via the p- catenin pathway. Altered cadherin expression is essential for embryonic development, tissue repair or healing, fibrosis, cancer and metastasis. Much interest has developed in cadherin expression and its regulation along with signalling in renal proximal

APA, Harvard, Vancouver, ISO, and other styles

24

Frohlich, Else Marie. "A microphysiological in vitro model of the renal proximal tubule reabsorptive barrier." Thesis, Boston University, 2014. https://hdl.handle.net/2144/12102.

Full text

Abstract:

Thesis (Ph.D.)--Boston University<br>Microfabricated in vitro kidney tissue models replicate essential components of in vivo kidney physiology, providing a platform for direct observation of controlled yet physiologically-representative kidney tissue. Currently, static and flat cell culture environments serve as platforms to study cell behavior, tissue structure formation, renal disease mechanisms, and drug development. Petri dishes, well plates, and flasks sustain cell growth, but their environments lacks physiological cues that are present in the in vivo environment, prompting cell responses

APA, Harvard, Vancouver, ISO, and other styles

25

Dangprapai, Yodying. "Human Multidrug and Toxin Extrusion Protein 1: Symmetry of substrate fluxes." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145435.

Full text

Abstract:

Human multidrug and toxin extrusion 1 (hMATE1) is a major candidate for being the molecular identity of organic cation/proton (OC/H+) exchange activity in the luminal membrane of renal proximal tubules (RPT). Although physiological function of hMATE1 supports luminal OC efflux, the kinetics of hMATE1-mediated OC transport have typically been characterized through measurement of uptake i.e., the interaction between outward-facing hMATE1 and OCs. To examine kinetics of hMATE1-mediated transport in a more physiologically relevant direction i.e., an interaction between inward-facing hMATE1 and c

APA, Harvard, Vancouver, ISO, and other styles

26

Karamanoli, Zoe. "Interactions between homocysteine and selenium metabolism in renal proximal tubular cells." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Glynne, Paul Alexander. "The role of inducible nitric oxide synthase in renal proximal tubule epithelial cells." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399540.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Marshall, Lisa Ann. "Detection and characterisation of a Na⁺/Li⁺ countertransporter in renal proximal tubule cells." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248638.

Full text

Abstract:

This study aimed to determine whether a functionally appropriate cell type, renal proximal tubule (PT) cells, displayed Na<sup>+</sup>/Li<sup>+</sup> countertransport activity, and if so, to characterise the exchange mechanism further and delineate any relationship with the NHE. Both freshly isolated rat PT cells and primary cultures of rabbit PT cells demonstrated SLC activity. Since Li<sup>+</sup> can take the place of Na<sup>+</sup> in various different exchange mechanisms, the contribution of the Na<sup>+</sup>/K<sup>+</sup> ATPase and NHE to the measured SLC activity was shown to be minim

APA, Harvard, Vancouver, ISO, and other styles

29

McGoldrick, Trevor A. "C-S lyase-mediated toxicity in primary cultures of proximal tubular cells." Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602010.

Full text

Abstract:

Halogenated alkenes are a group of commercially important chemicals. For example tetrafluoroethylene is the monomer used for the production of poly- tetrafluoroethylene, hexachloro-1:3-butadiene is a by-product from the manufacture of chlorinated solvents and perchloroethylene is widely used as a dry cleaning agent. Due to possible exposure to haloalkenes and the nephrotoxicity observed in animal studies, concern has been expressed for the potential of these compounds to cause toxicity to man. Animal studies have shown that these compounds undergo inter-organ metabolism and are bioactivated by

APA, Harvard, Vancouver, ISO, and other styles

30

梁艾悔 and Emily C. Liong. "Renal proximal tubular glycosaminoglycans-isolation, characterization and involvement in calcium oxalate crystallization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31235074.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Liong, Emily C. "Renal proximal tubular glycosaminoglycans-isolation, characterization and involvement in calcium oxalate crystallization /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17398095.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Sharma, Asheesh. "Reactive oxygen species in human renal proximal tubular cells overloaded with albumin." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526897.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Bakhiya, Nadiya. "Functional characterization of the human renal organic anion transporter 3 (hOAT3) and comparison to hOAT1." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972298029.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Breda, Philippe Christophe [Verfasser]. "Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T cell responses : Renale proximale Tubulusepithelzellen üben durch Auslösen von inflammatorischen T-Zell-Antworten eine immunmodulatorische Funktion aus / Philippe Christophe Breda." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1221276344/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Gilman, Morgan SA. "Differential Cytoskeletal Responses to ATP Depletion and Repletion in Renal Proximal Tubule and Interstitial Fibroblast Cells." Fogler Library, University of Maine, 2011. http://www.library.umaine.edu/theses/pdf/GilmanM2011.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Jones, Caroline Elizabeth Mary. "The development, evaluation and use of freshly isolated renal proximal tubule systems from the Fischer rat." Thesis, Aston University, 1990. http://publications.aston.ac.uk/12575/.

Full text

Abstract:

The investigation of renal pathophysiology and toxicology has traditionally been advanced by the development of increasingly defined and refined in vitro preparations. This study has sought to develop and evaluate various methods of producing pure samples of renal proximal tubules (PTs) from the Fischer rat. The introduction summarised the most common in vitro preparations together with the parameters used to monitor viability - particularly with regard to toxic events. The most prevalent isolation methods have involved the use of collagenase to produce dissociation of the cortex. However, the

APA, Harvard, Vancouver, ISO, and other styles

37

Luo, Dong-Dong. "Regulation of transforming growth factor beta-1 signalling in the renal proximal tubular epithelial cells." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55488/.

Full text

Abstract:

The data presented shows that IL-1beta has a biphasic effect on PTC TGF-beta signalling, with early NF-kappaB-mediated inhibition and delayed sensitization via an autocrine IL-6 loop, and possibly also via an autocrine IL-6 loop, and possibly also via a switch from NF Kappa B p52/p50 heterodimer to p50/p50 homodimer formation. Secondly, the data indicates that BMP-7 prevents TGF-beta1-mediated loss of the transcriptional repressor SnoN and hence specifically limits Smad3 DNA binding, altering the balance of transcriptional responses to TGF-beta1 in PTC.

APA, Harvard, Vancouver, ISO, and other styles

38

Amara, Alieu Badarr. "Effects of chronic albumin overload in renal proximal tubular cell catabolism and on oxidative stress." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539748.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Gordon, Elaine Mary. "Isolated rat renal proximal tubular cells : a model for the study of drug-induced nephrotoxicity." Thesis, University of Aberdeen, 1990. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU546772.

Full text

Abstract:

Renal proximal tubular cells (&'62 90&'37) were isolated from the rat in high yield by collagenase digestion of renal cortical tissue, followed by isopycnic centrifugation in a Percoll density gradient. The cells were of high viability and their identity verified by morphology and PT specific enzyme activities. Cytochrome P450 and dependent monooxygenase activities were maintained and the rapid decline in reduced glutathione prevented by addition of glycine, glutamate and cystine to the buffers used. These parameters were also maintained in culture (24h). Cytochrome P450-dependent monooxygenas

APA, Harvard, Vancouver, ISO, and other styles

40

Afonso, Sara Cerqueira [Verfasser], and Richard [Akademischer Betreuer] Warth. "Role of EHD1 in Renal Proximal Tubular Endocytosis and Recycling / Sara Cerqueira Afonso ; Betreuer: Richard Warth." Regensburg : Universitätsbibliothek Regensburg, 2018. http://d-nb.info/1175625272/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Afrin, Sadia. "Defining a 3-dimensional (3D) in vitro model to study immune cell and renal cell interactions." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84754/1/Sadia_Afrin_Thesis.pdf.

Full text

Abstract:

This study aimed to develop a 3-Dimensional (D) hydrogel system for the co-culture of autologous human renal and immune cells. Previous studies have shown that human renal epithelial cells are able to modulate autologous immune cell responses. However, these studies were undertaken in a standard 2D culture system. The 3D model was developed to re-capitulate these observations within a more physiological relevant in vivo like environment.

APA, Harvard, Vancouver, ISO, and other styles

42

Pessoa, Thaíssa Dantas. "Efeito da glicose e da atividade do co-transportador Na+-glicose, isoformas 1 e 2, sobre o trocador Na+/H+, isoforma 3 em túbulos proximais: papel do metabolismo glicolítico, do transporte de água e da localização dos transportadores." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-18062014-103343/.

Full text

Abstract:

Está bem estabelecido na literatura que o NHE3 é ativado, no intestino, pelo transporte de glicose mediado pelo SGLT1, e que esta ativação não dependente do metabolismo da glicose. Acredita-se que a co-ativação do NHE3 e do SGLT1 ocorra para maximizar a reabsorção de nutrientes no período pós-prandial. Porém, ainda não foi determinado se a captação de glicose através dos SGLTs é capaz de regular a atividade do NHE3 no túbulo proximal renal. Levando-se em conta que este segmento renal também expressa o SGLT2 e que os rins e intestinos apresentam significativas diferenças na disponibilidade de g

APA, Harvard, Vancouver, ISO, and other styles

43

Xiao, Jing, and 肖婧. "Crosstalk between peroxisome proliferator-activated receptor-[gamma] and angiotensin II in renal proximal tubular epithelial cells in IgAnephropathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42182384.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Ho, Sau-kwan, and 何秀鈞. "Interactions of anti-dsDNA antibodies with human proximal renal tubular epithelial cells in the pathogenesis of lupus nephritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197161.

Full text

Abstract:

Lupus nephritis is characterized by the production of anti-dsDNA antibodies, deposition of immune complexes within the kidney parenchyma, proliferation of resident renal cells and induction of inflammatory and fibrotic processes. Approximately 70% of patients with lupus nephritis show immune aggregates along the tubular basement membrane, which is accompanied by an influx of infiltrating cells and increased intra-renal expression of IL-6. Much attention has focused on the inflammatory processes in the kidney during pathogenesis of lupus nephritis whereas mechanisms of fibrogenesis are less wel

APA, Harvard, Vancouver, ISO, and other styles

45

McLaren, John. "Human renal proximal tubular cells, in suspension and primary culture, as in vitro models of drug-induced nephrotoxicity." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU545620.

Full text

Abstract:

The kidney is the target for a wide variety of chemical agents, including heavy metals, haloalkenes, analgesics and antibiotics. The functional and metabolic characteristics of the proximal tubule (PT) predispose it as the primary site for xenobiotic damage. The aim of this study was to isolate and characterise human and rat PT cells in suspension and primary culture for use as defined models to investigate drug-induced PT cell damage in vitro . A second aim was to compare the response of human and rat systems to known nephrotoxins. Human and rat PT cells (90&'37 viable) were isolated from kid

APA, Harvard, Vancouver, ISO, and other styles

46

Faustino, Viviane Dias. "Efeito de uma disfunção da barreira glomerular sobre a imunidade inata de células tubulares proximais." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-03072018-085305/.

Full text

Abstract:

A sobrecarga de proteínas nas células tubulares proximais pode levar a lesão intersticial por mecanismos não claros que podem envolver a ativação da imunidade inata. Nós investigamos a hipótese de que a exposição prolongada de células tubulares a altas concentrações de proteínas estimula a imunidade inata, desencadeando inflamação intersticial progressiva e lesão renal. Além disso, investigamos se a inibição específica da imunidade inata ou adaptativa proporcionaria renoproteção em um modelo estabelecido de proteinúria maciça, nefropatia por adriamicina (ADR). Os ratos adultos Munich-Wistar re

APA, Harvard, Vancouver, ISO, and other styles

47

Xiao, Jing. "Crosstalk between peroxisome proliferator-activated receptor-[gamma] and angiotensin II in renal proximal tubular epithelial cells in IgA nephropathy." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42182384.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Sheremet, Andriy. "Bioinspired polyethersulfone-based hollow fiber membranes as the scaffolds in renal assist device for protein-bound toxins removal from blood." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/13308.

Full text

Abstract:

Dissertation for obtaining the Master degree in Membrane Engineering<br>Erasmus Mundus Master in Membrane Engineering<br>Using bioartificial kidney is the promising approach for removal of non-dializable, proteinbound uremic toxins, which are responsible for high mortality and morbidity in treating kidney failure related conditions. Additionaly, bioartificial kidney device could perform the physiological roles of the kidney such as metabolic replacement, endocrine function and immunomodulation. In the current work two commercial polyethersulfone-based membranes, Gambro HCO 1100 and Membrana

APA, Harvard, Vancouver, ISO, and other styles

49

Ginai, Maaria. "Incorporating primary human renal proximal tubule cells into a hollow fibre bioreactor in the development of an in vitro model for pharmaceutical research." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/20110.

Full text

Abstract:

Current in vitro cellular methods utilised in drug metabolism and pharmacokinetic (DMPK) studies during drug development do not provide the 3D structure and functions of organs found in vivo, such that resulting in vitro-in vivo extrapolation (IVIVE) may not always accurately reflect clinical outcome. This highlights the need for the development of new dynamic in vitro cell models to aid improvement of IVIVE. The aim of this project was to incorporate characterised primary renal cells within a hollow fibre bioreactor for use in DMPK studies investigating renal clearance. Fluorescence based ass

APA, Harvard, Vancouver, ISO, and other styles

50

Wang, Bin. "Enhanced cadmium-induced testicular necrosis and renal proximal tubular damage caused by gene-dose increase in a Slc39a8-Transgenic mouse line." Cincinnati, Ohio : University of Cincinnati, 2007. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1172086886.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!