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Journal articles on the topic 'Proz'

Author: Grafiati

Published: 4 May 2022

Last updated: 30 July 2025

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1

Xu, Zuying, Ying Zhang, Wei Liu, et al. "Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women." Clinical and Applied Thrombosis/Hemostasis 24, no. 6 (2018): 894–900. http://dx.doi.org/10.1177/1076029617750487.

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Mutations of hemostasis/coagulation-related genes have been speculated to cause recurrent spontaneous abortion (RSA). This study investigated the genetic association between the polymorphisms of factor V (F5), factor II (F2), antithrombin (SERPINC1), protein C (PROC), protein S (PROS1), protein Z (PROZ), factor XIII (F13A1), and carboxypeptidase B2 (CPB2) genes and RSA. The 426 patients with RSA and 444 controls were recruited in this study, and single-nucleotide polymorphisms (SNPs) were analyzed by using SNPscan technology. Genotype and allele frequencies of rs3136520 in F2, rs3024731 in PRO

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Chen, Yinkui, Xiusheng Qiu, Donghao Wu, et al. "PROZ Associated with Sorafenib Sensitivity May Serve as a Potential Target to Enhance the Efficacy of Combined Immunotherapy for Hepatocellular Carcinoma." Genes 13, no. 9 (2022): 1535. http://dx.doi.org/10.3390/genes13091535.

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Targeted combined immunotherapy has significantly improved the prognosis of patients with advanced hepatocellular carcinoma and has now become the primary treatment for advanced hepatocellular carcinoma. However, some patients still have poor efficacy or are resistant to treatment. The further exploration of molecular markers related to efficacy or finding molecular targets to increase efficacy is an urgent problem that needs to be resolved. In this research, we found that PROZ was a gene related to KDR expression that had significantly low expression in cancer tissue by analyzing the differen

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Haj, Amelia K., Sean J. Jurgens, Xin Wang, et al. "Protein Z ( PROZ) Loss of Function Is Associated with Increased Risk of Ischemic Stroke in 416,767 UK Biobank Participants." Blood 142, Supplement 1 (2023): 2611. http://dx.doi.org/10.1182/blood-2023-182861.

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Background:The vitamin K-dependent coagulation factor protein Z ( PROZ) is canonically considered to have anticoagulant effects through its negative regulation of factor Xa. However, the true role of protein Z in coagulation is controversial, with conflicting data on the impact of plasma protein Z levels across a range of thrombotic phenotypes. In particular, higher circulating protein Z concentrations have consistently been associated with an elevated risk of acute ischemic stroke, but there is little explanation for this apparent paradox. Because studies of plasma protein levels are especial

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Brill, Jeanette, Tamara Hoffmann, Harald Putzer, and Erhard Bremer. "T-box-mediated control of the anabolic proline biosynthetic genes of Bacillus subtilis." Microbiology 157, no. 4 (2011): 977–87. http://dx.doi.org/10.1099/mic.0.047357-0.

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Bacillus subtilis possesses interlinked routes for the synthesis of proline. The ProJ–ProA–ProH route is responsible for the production of proline as an osmoprotectant, and the ProB–ProA–ProI route provides proline for protein synthesis. We show here that the transcription of the anabolic proBA and proI genes is controlled in response to proline limitation via a T-box-mediated termination/antitermination regulatory mechanism, a tRNA-responsive riboswitch. Primer extension analysis revealed mRNA leader transcripts of 270 and 269 nt for the proBA and proI genes, respectively, both of which are s

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O'NEAL, Kevin D., Mohan V. CHARI, Charles H. McDONALD, et al. "Multiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy." Biochemical Journal 315, no. 3 (1996): 833–44. http://dx.doi.org/10.1042/bj3150833.

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An eight-amino-acid synthetic peptide (Ile1-Phe2-Pro3-Pro4-Val5-Pro6-Gly7-Pro8) corresponding to the conserved proline-rich motif (PRM) of the intracellular domain of the prolactin receptor (PRL-R) was studied by one- and two-dimensional (1D and 2D) proton NMR spectroscopy in water and DMSO in order to characterize its conformational dynamics. The purified PRL-R PRM peptide eluted as two partially resolved peaks in equilibrium on reverse-phase HPLC (RP-HPLC) at 20 °C with a ratio of 60:40. At 30 °C, the two peaks coalesced into a single peak. The two RP-HPLC peaks correspond to two peptide con

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Kreft, Iris charlotte, Eva Smit, Eleonora Camilleri, et al. "The Plasma Proteomic Landscape of Thrombotic Events across Multi-Center Cohorts." Blood 142, Supplement 1 (2023): 5395. http://dx.doi.org/10.1182/blood-2023-185936.

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Background: Diagnosis and risk prediction of thrombosis is challenging due to nonspecific symptoms, diverse risk factors, symptom overlap with other conditions and the variability in thrombosis presentations. Little is known on the impact of thrombosis on the plasma proteome across the spectrum of its clinical representations. Objective: The aim of this study was to explore the plasma proteomic landscape across multi-center thrombosis cohorts. The focus was on identifying protein signatures representative of thrombosis in general or among patients at risk of thrombosis, those with a history of

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Belitsky, Boris R., Jeanette Brill, Erhard Bremer, and Abraham L. Sonenshein. "Multiple Genes for the Last Step of Proline Biosynthesis in Bacillus subtilis." Journal of Bacteriology 183, no. 14 (2001): 4389–92. http://dx.doi.org/10.1128/jb.183.14.4389-4392.2001.

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ABSTRACT The complete Bacillus subtilis genome contains four genes (proG, proH, proI, and comER) with the potential to encode Δ1-pyrroline-5-carboxylate reductase, a proline biosynthetic enzyme. Simultaneous defects in three of these genes (proG, proH, and proI) were required to confer proline auxotrophy, indicating that the products of these genes are mostly interchangeable with respect to the last step in proline biosynthesis.

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Jiang, Xiaocong, Ting Song, Xiuhua Pan, Xinyu Zhang, Yuhong Lan, and Li Bai. "PROZ May Serve as a Prognostic Biomarker for Early Hepatocellular Carcinoma." International Journal of General Medicine Volume 14 (August 2021): 4209–18. http://dx.doi.org/10.2147/ijgm.s311959.

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9

Pinto e Vairo, Filippo, Sarah A. Kroc, Nicole L. Bertsch, et al. "Biallelic variants in PROZ as a cause of hypercoagulability and livedo racemosa." Thrombosis Research 195 (November 2020): 187–89. http://dx.doi.org/10.1016/j.thromres.2020.07.014.

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Jadwisieńczak, Krzysztof Konrad, Joanna Majkowska-Gadomska, Anna Francke, and Zdzisław Kaliniewicz. "An Evaluation of the Physical and Chemical Parameters in Brassica Seedlings Grown on Various Organic Substrates." Applied Sciences 13, no. 16 (2023): 9124. http://dx.doi.org/10.3390/app13169124.

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Horticultural substrates should promote seed germination and seedling emergence. The value of the SPAD index was significantly influenced by the type of substrate. The substrates had a beneficial effect on plant height in comparison with the control substrate. Brassica plants grown on the substrates used in the experiment had a compact growth habit, which is a desirable trait in seedling production. In general, macronutrient uptake differed in Brassica plants grown on various substrates. Significant differences in this parameter were observed mainly in broccoli (increase of approx. 14%) and wh

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Zubrzak, P., K. Kociołek, M. Smoluch, et al. "Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I." Acta Biochimica Polonica 48, no. 4 (2001): 1151–54. http://dx.doi.org/10.18388/abp.2001_3882.

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Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3 Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile2-psi[CN4]-Ala3', Pro3-psi[CN4]-Ala4 and Val6-psi[CN4]-Ala7 were synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).

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12

Culham, Doreen E., Katherine S. Emmerson, Bonnie Lasby, et al. "Genes encoding osmoregulatory proline/glycine betaine transporters and the proline catabolic system are present and expressed in diverse clinical Escherichia coli isolates." Canadian Journal of Microbiology 40, no. 5 (1994): 397–402. http://dx.doi.org/10.1139/m94-065.

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Sixty-three clinical isolates identified as Escherichia coli, 30 from the human urinary tract and 33 derived from other human origins, were screened for proline/glycine betaine transporters similar to those that support proline catabolism and proline- or glycine betaine-based osmoregulation in E. coli K-12. Both molecular (DNA- and protein-based) analyses and physiological tests were performed. All tests were calibrated with E. coli K-12 derivatives from which genetic loci putP (encoding a proline transporter required for proline catabolism), proP, and (or) proU (loci encoding osmoregulatory p

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Li, Hongchuan, Hong Lou, Michael Dean, and Stephen Anderson. "Characterization of the bidirectional activity of the human TET2 gene promoters." Journal of Immunology 204, no. 1_Supplement (2020): 79.11. http://dx.doi.org/10.4049/jimmunol.204.supp.79.11.

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Abstract Tet methylcytosine dioxygenase 2 (TET2) is a tumor suppressor gene that is inactivated in a wide range of hematological cancers. TET2 enzymatic activity converts 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC), an essential step in DNA demethylation. Human TET2 is highly expressed in pluripotent cells and down-regulated in differentiated cells. However, transcriptional regulation of the human TET2 gene underlying functional and biological implications has not been investigated in detail. We previously reported three promoters, designated as Pro1, Pro2, and Pro3, generate

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14

Zhang, Lili, Alan Z. Segal, Dana Leifer, et al. "Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults." Thrombosis and Haemostasis 117, no. 01 (2017): 149–57. http://dx.doi.org/10.1160/th16-04-0277.

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SummaryProtein Z (PZ) is a vitamin K–dependent plasma protein that exhibits both pro- and anticoagulant properties. Both low and high PZ levels have been linked to ischaemic stroke. Although PZ-lowering gene variants have been found to be less common in ischaemic stroke, the relationship remains unclear. We investigated PZ levels and PROZ variants in a multi-ethnic case-control study of unexplained stroke in participants aged 18 to 64. Plasma PZ was measured in cases (≥2 months post-stroke) and controls. PZ polymorphisms G79A (rs3024735) and A13G (2273971) were genotyped. A combined genetic sc

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Wetwittayakhlang, Panu, Siripoom Ngampech, Saichol Pattarakulniyom, and Peter L. Lakatos. "Objective Treatment Targets and Their Correlation with Patient-Reported Outcomes in Inflammatory Bowel Disease: A Real-World Study." Journal of Clinical Medicine 14, no. 13 (2025): 4733. https://doi.org/10.3390/jcm14134733.

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Background & Aims: treat-to-target approach is essential for improving outcomes in inflammatory bowel disease (IBD). This study aimed to assess real-world achievement in objective monitoring (clinical, biomarker, and endoscopic assessments) and the correlation between patient-reported outcomes (PROs) and treatment targets. Methods: This retrospective study included consecutive IBD patients from January 2020 to December 2024. Disease activity was assessed using the Harvey-Bradshaw Index (HBI), partial Mayo score, PRO2, and PRO3, along with C-reactive protein (CRP) levels and endoscopic scor

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Romantsov, Tatyana, Andrew R. Battle, Jenifer L. Hendel, Boris Martinac, and Janet M. Wood. "Protein Localization in Escherichia coli Cells: Comparison of the Cytoplasmic Membrane Proteins ProP, LacY, ProW, AqpZ, MscS, and MscL." Journal of Bacteriology 192, no. 4 (2009): 912–24. http://dx.doi.org/10.1128/jb.00967-09.

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ABSTRACT Fluorescence microscopy has revealed that the phospholipid cardiolipin (CL) and FlAsH-labeled transporters ProP and LacY are concentrated at the poles of Escherichia coli cells. The proportion of CL among E. coli phospholipids can be varied in vivo as it is decreased by cls mutations and it increases with the osmolality of the growth medium. In this report we compare the localization of CL, ProP, and LacY with that of other cytoplasmic membrane proteins. The proportion of cells in which FlAsH-labeled membrane proteins were concentrated at the cell poles was determined as a function of

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17

MONSEES, THOMAS K., WERNER MISKA, and WOLF‐BERNHARD SCHILL. "Enzymatic Digestion of Bradykinin by Rat Sertoli Cell Cultures." Journal of Andrology 17, no. 4 (1996): 375–81. http://dx.doi.org/10.1002/j.1939-4640.1996.tb01803.x.

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ABSTRACT: Sertoli cells play a key role in spermatogenesis. To study the involvement of the kallikrein‐kinin system in the testis, the pattern of bradykinin‐inactivating kininases in rat Sertoli cells was investigated. Exogenous bradykinin (Arg1‐Pro2‐Pro3‐Gly4‐Phe5‐Ser6‐Pro8‐Phe8‐Arg9) is cleaved at Pro7‐Phe8, Phe5‐Ser6, and Gly4‐Phe5, as demonstrated by high performance liquid chromatography analysis. Degradation of bradykinin was strongly inhibited by phosphoramidon and thiorphan, which are specific inhibitors of neutral metalloendopeptidase‐24.11. The kininase type II‐specific inhibitors, c

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Annamalai, Thirunavukkarasu, and Kumar Venkitanarayanan. "Role of proP and proU in Betaine Uptake by Yersinia enterocolitica under Cold and Osmotic Stress Conditions." Applied and Environmental Microbiology 75, no. 6 (2008): 1471–77. http://dx.doi.org/10.1128/aem.01644-08.

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ABSTRACT Yersinia enterocolitica is a food-borne pathogen with the ability to grow at cold temperatures and tolerate high osmolarity. The bacterium tolerates osmotic stress by intracellular accumulation of osmolytes, such as betaine. The proP gene and proU operon of Y. enterocolitica were sequenced, and single (ProP− ProU+ and ProP+ ProU−) and double (ProP− ProU−) mutants were generated. Upon exposure to osmotic or chill stress, the single and double mutants demonstrated a reduction in betaine uptake compared to that in the wild type, suggesting that proP and proU play a role in betaine uptake

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Kunte, H. Jörg, Rebecca A. Crane, Doreen E. Culham, Deborah Richmond, and Janet M. Wood. "Protein ProQ Influences Osmotic Activation of Compatible Solute Transporter ProP in Escherichia coliK-12." Journal of Bacteriology 181, no. 5 (1999): 1537–43. http://dx.doi.org/10.1128/jb.181.5.1537-1543.1999.

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ABSTRACT ProP is an osmoregulatory compatible solute transporter inEscherichia coli K-12. MutationproQ220::Tn5 decreased the rate constant for and the extent of ProP activation by an osmotic upshift but did not alter proP transcription or the ProP protein level. Allele proQ220::Tn5 was isolated, and the proQ sequence was determined. LocusproQ is upstream from prc (tsp) at 41.2 centisomes on the genetic map. TheproQ220::Tn5 and prcphenotypes were different, however. Gene proQ is predicted to encode a 232-amino-acid, basic, hydrophilic protein (molecular mass, 25,876 Da; calculated isoelectric p

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Anderson, Stephen, Matthew V. McCullen, Shurjo Sen, and Daniel W. McVicar. "Ly49 Pro1 activity is associated with gene activation, not gene expression: Pro1 transcripts are not present in mature Ly49-expressing NK cells." Journal of Immunology 196, no. 1_Supplement (2016): 202.3. http://dx.doi.org/10.4049/jimmunol.196.supp.202.3.

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Abstract Recent studies of the Ly49 loci have challenged the traditional view of promoters, since transcriptional start sites for the variegated Ly49 genes were not found to be associated with regions possessing transcriptional activity in in vitro promoter assays. The upstream Pro1 bidirectional promoter previously associated with probabilistic activation of variegated Ly49 genes by immature bone marrow NK cells was shown to be active in mature NK cells and function as an enhancer element, suggesting that it may play a role in Ly49 transcript initiation in mature NK cells. To directly assess

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Cosquer, Anne, Vianney Pichereau, Jean-Alain Pocard, Jacques Minet, Michel Cormier, and Théophile Bernard. "Nanomolar Levels of Dimethylsulfoniopropionate, Dimethylsulfonioacetate, and Glycine Betaine Are Sufficient To Confer Osmoprotection to Escherichia coli." Applied and Environmental Microbiology 65, no. 8 (1999): 3304–11. http://dx.doi.org/10.1128/aem.65.8.3304-3311.1999.

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ABSTRACT We combined the use of low inoculation titers (300 ± 100 CFU/ml) and enumeration of culturable cells to measure the osmoprotective potentialities of dimethylsulfoniopropionate (DMSP), dimethylsulfonioacetate (DMSA), and glycine betaine (GB) for salt-stressed cultures of Escherichia coli. Dilute bacterial cultures were grown with osmoprotectant concentrations that encompassed the nanomolar levels of GB and DMSP found in nature and the millimolar levels of osmoprotectants used in standard laboratory osmoprotection bioassays. Nanomolar concentrations of DMSA, DMSP, and GB were sufficient

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Riccardi, Federica, Gianna F. Rivolta, Vera Uliana, et al. "Cryptic 13q34 and 4q35.2 Deletions in an Italian Family." Cytogenetic and Genome Research 147, no. 1 (2015): 24–30. http://dx.doi.org/10.1159/000442068.

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Variations of DNA sequences in the human genome range from large, microscopically visible chromosome anomalies to single nucleotide changes. Submicroscopic genomic copy number variations, i.e. chromosomal imbalances which are undetectable by conventional cytogenetic analysis, play an intriguing clinical role. In this study, we describe the clinical consequences of the concurrent presence of an interstitial deletion in 13q34 and a terminal deletion in 4q35.2 in an Italian family. The index patient, a 19-year-old male, as well as his 12-year-old sister are carriers of both deletions, one of mate

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Fazly, Riazulhaq, Nafla Raees, Muhammad Qaiser Shafi, Shakir Iqbal, and Muhammad Javid Nawaz. "Impact of project planning and project risk management on project success: moderating role of project managers’ competencies in the construction sector in Afghanistan." Journal of Humanities, Social and Management Sciences (JHSMS) 5, no. 2 (2024): 1–20. http://dx.doi.org/10.47264/idea.jhsms/5.2.1.

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This research examines the impact of project planning (ProP) and project risk management (RisM) on project success (ProS) while maintaining project managers’ competencies (PMC) as moderators using resource-based view theory concepts. This research addresses the gap in how ProP and RisM lead to ProS in the presence of a PMC as a moderator in construction-based private organisations. Utilising a convenience sampling technique, data were collected from 249 participants working in construction-based organizations across major cities in Afghanistan. Data were analysed using Smart-PLS and SPSS softw

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Taldaev, Amir, Roman P. Terekhov, Elizaveta V. Melnik, et al. "Insights into the Cardiotoxic Effects of Veratrum Lobelianum Alkaloids: Pilot Study." Toxins 14, no. 7 (2022): 490. http://dx.doi.org/10.3390/toxins14070490.

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Jervine, protoveratrine A (proA), and protoveratrine B (proB) are Veratrum alkaloids that are presented in some remedies obtained from Veratrum lobelianum, such as Veratrum aqua. This paper reports on a single-center pilot cardiotoxic mechanism study of jervine, proA, and proB in case series. The molecular aspects were studied via molecular dynamic simulation, molecular docking with cardiac sodium channel NaV1.5, and machine learning-based structure–activity relationship modeling. HPLC-MS/MS method in combination with clinical events were used to analyze Veratrum alkaloid cardiotoxicity in pat

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Trivisiol, Vinicius Severo, Alberto Cargnelutti Filho, Murilo Vieira Loro, and Giovani Facco. "Progresso genético de trigo de ciclos precoce e tardio nos estados do Rio Grande do Sul e Paraná." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 21, no. 11 (2023): 22810–25. http://dx.doi.org/10.55905/oelv21n11-226.

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O objetivo deste trabalho foi determinar o progresso genético da produtividade de grãos, peso de mil grãos, peso do hectolitro e proteína em grãos de trigo de ciclos precoce e tardio, nos estados do Rio Grande do Sul e Paraná. Foram utilizados os dados de 106 ensaios com genótipos de ciclo precoce e 124 de ciclo tardio, conduzidos durante cinco anos (2015, 2016, 2017, 2018 e 2019), nos estados do Rio Grande do Sul e Paraná. Foram avaliados os seguintes caracteres: produtividade de grãos (PROD, em kg ha-1), peso de mil grãos (PMG, em g), peso do hectolitro (PH, em kg hL-1) e proteína dos grãos

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Formstone, CJ, PJ Hallam, EG Tuddenham, et al. "Severe perinatal thrombosis in double and triple heterozygous offspring of a family segregating two independent protein S mutations and a protein C mutation." Blood 87, no. 9 (1996): 3731–37. http://dx.doi.org/10.1182/blood.v87.9.3731.bloodjournal8793731.

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Molecular genetic and phenotypic analyses were performed in a highly unusual case of combined protein S and protein C deficiency manifesting in a family in which a child had died perinatally from renal vein thrombosis. Antenatal diagnosis in a second pregnancy was initially performed by indirect restriction fragment length polymorphism (RFLP) tracking using a neutral dimorphism within the PROS gene and served to exclude severe protein S deficiency. Am umbilical vein blood sample at 22 weeks gestation showed isolated protein C deficiency. This pregnancy proceeded to a full-term delivery without

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Milašius, Kazys. "Žurnalui „Sporto mokslas“ – 30 metų: praeitis, dabartis ir ateities perspektyvos." Sporto mokslas / Sport Science 106 (2024): 5–9. http://dx.doi.org/10.15823/sm.2024.106.1.

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Žurnalas „Sporto mokslas“ mini garbingą sukaktį – jis leidžiamas jau 30 metų. Per šį laikotarpį nueitas ilgas, sudėtingas raidos ir brandos kelias, kuris leidžia vadintis neatsiejama Lietuvos sporto mokslo dalimi. Šiuo metu Leidėjų tarybai vadovauja Vytauto Didžiojo universiteto Švietimo akademijos kanclerė prof. dr. Lina Kaminskienė ir Lietuvos olimpinės akademijos prezidentė prof. dr. Asta Šarkauskienė, žurnalo vyr. redaktorius – prof. habil. dr. Kazys Milašius. Skyrių atsakingųjų ir redaktorių tarybą sudaro 26 asmenys, iš kurių 16, arba 61,5 proc., yra įžymūs užsienio šalių sporto mokslinin

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Kotovych, George, John R. Cann, John M. Stewart, and Hitoshi Yamamoto. "NMR and CD conformational studies of bradykinin and its agonists and antagonists: application to receptor binding." Biochemistry and Cell Biology 76, no. 2-3 (1998): 257–66. http://dx.doi.org/10.1139/o98-028.

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Most physiological processes are regulated by peptides that perform their functions by interacting with specific receptors on cells. Specific conformations of the peptides are required for correct interactions to take place, and a knowledge of the biologically important conformation is vital for the understanding of biological function. Over the last few years extensive studies using nuclear magnetic resonance and circular dichroism have been carried out on bradykinin (Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) and its antagonists with the objective of developing new drugs to combat severe

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Da Rosa Sarturi, Marlon Vinicius, Cleusa Adriane Menegassi Bianchi Teixeira, Ivan Ricardo Carvalho, et al. "PREDICTION OF CORN GRAIN PRODUCTIVITY AS A FUNCTION OF ALTITUDE AND PLANT POPULATION." REVISTA DE AGRICULTURA NEOTROPICAL 9, no. 4 (2022): e7070. http://dx.doi.org/10.32404/rean.v9i4.7070.

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This study aimed to evidence the best arrangement of plants according to altitudes to potentialize corn grain yield. An information survey was performed in the 2019/20 harvest, using 144 producers responsible for corn grain production fields totaling 2,301.3 hectares in 144 environments of Rio Grande do Sul. Within 144 environments, 14 corn hybrids were arranged: DKB 240 PRO, DOW 2A620, AG 9045 PRO3, AS1555 PRO3, AS1572 PRO2, AS1656, BIOGENE 7046, DKB 250 PRO2, DKB 290 PRO3, DKB 330RR, NS56, P1630HX, P30F53HX, and SH7910. Yield, morphological, and phenological variables were measured, and geog

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DiSilvestro, Adrianna N., Lauren T. Wesolowski, Pier L. Semanchik, et al. "PSI-8 Inflammatory cytokine concentrations and gene expression in mature and aging sedentary horses." Journal of Animal Science 102, Supplement_3 (2024): 468–69. http://dx.doi.org/10.1093/jas/skae234.531.

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Abstract Chronic inflammation associated with aging, termed “inflamm-aging” may negatively impact overall animal health. However, the mechanisms of inflamm-aging and, therefore, effective interventions, remain unknown. Nuclear factor erythroid 2-related factor 2 (Nrf2; NFE2L2) is a transcription factor that controls antioxidant gene expression and could be a target for promoting anti-inflammatory pathways. To test the hypothesis that supplementation of nonenzymatic derived antioxidants (Protandim Nrf2 Synergizer, LifeVantage Corporation) would activate Nrf2 and mitigate inflammation, 40 mature

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Budarina, Yu V. "On the Issue of Developing PROM as Part of the Value-based Healthcare." City Healthcare 6, no. 2 (2025): 74–84. https://doi.org/10.47619/2713-2617.zm.2025.v.6i2;74-84.

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Background. Value-based healthcare is becoming the main theme of restructuring and improving modern healthcare systems around the world. The value of medical care for the patient is at the forefront; therefore, in order to make effective decisions, it is important to measure the effect of the treatment by taking into account the data reported by patients. This article provides a brief description of the concepts of patient-reported outcomes (PROs), indicators for measuring them (PROMs) and their significance in value-based healthcare. Based on the analysis of foreign publications, the basic pr

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Liao, Chen-Chung, Jin-Wei Xu, Wen-Ching Huang, Hung-Chang Chang, and Yu-Tang Tung. "Plasma Proteomic Changes of Atherosclerosis after Exercise in ApoE Knockout Mice." Biology 11, no. 2 (2022): 253. http://dx.doi.org/10.3390/biology11020253.

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Atherosclerosis is the preliminary cause of coronary artery disease, one of the diseases that account for the largest number of fatal mortalities. Physical activity is an effective strategy to restrain atherosclerosis from deterioration. Evidence indicated that changes in the proteomic profile are highly associated with atherosclerosis development, but the mechanism behind exercise for atherosclerosis amelioration has not yet been investigated from a proteomics perspective. Hence, the proteomic profiles could further elucidate the systematic effects of exercise intervention on ApoE knockout at

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Malandrini, Francesco, Cesare Borroni, Michela Meregaglia, Massimiliano Sarra, and Oriana Ciani. "The role of patient-reported outcomes in reimbursement decisions and drug innovation in Italy." Global & Regional Health Technology Assessment 10 (February 9, 2023): 12–17. http://dx.doi.org/10.33393/grhta.2023.2514.

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The attention paid by regulatory authorities to patient-reported outcomes (PROs) and their related measures (PROMs) has progressively increased to allow for a more complete description of the patient’s health status. This work aimed at investigating the use of PROs/PROMs in relation to reimbursement agreement and innovativeness recognition by the Italian Medicines Agency (AIFA). The list of European Public Assessment Reports (EPARs), downloaded from the European Medicine Agency (EMA) website, was analyzed to identify drugs authorized between 2017 and 2021. The associations between the use of P

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Queiroz, Pedro, Israel Alves Filho, Sergio Pereira Junior, et al. "PSIX-10 In vitro dry matter digestibility, gas production and pH of silages of several maize hybrids." Journal of Animal Science 98, Supplement_4 (2020): 415–16. http://dx.doi.org/10.1093/jas/skaa278.725.

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Abstract The objective of this study was to determine the in vitro dry matter digestibility (IVDMD), gas production and pH of silages of 10 maize hybrids in Iturama, Brazil (XB 6012 BT, BM 709 VT PRO2, BM 815 VT PRO2, DKB 363 VT PRO3, AG 8740 VT PRO3, SYN 555 VIP3, SX 8555 VIP3, SX 7005 VIP3, DKB 390 VT PRO3, and RB 9789 VIP3). The maize was ensiled in experimental mini silos in a completely randomized design with 3 repetitions. After 120 d, a subsample from each mini silo was taken and the IVDMD was estimated using Ankom Daisy II and F-57 bags (n = 44). Rumen fluid from two cannulated Nellore

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Begdildayeva, N. Zh, Sh N. Akhmetsadykova, A. S. Nurgazina, A. K. Kudaibergenova, and N. N. Akhmetsadykov. "Study of the effect of probiotics on the shelf life of chilled broiler meat." Journal of Almaty Technological University 1, no. 3 (2023): 45–51. http://dx.doi.org/10.48184/2304-568x-2023-3-45-51.

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Poultry meat can be contaminated with a wide range of microorganisms, including those that can spoil the product during chill storage and certain foodborne pathogens. This study aims to investigate the effect of probiotics on the shelf life of shilled broiler meat. The object of the study was fresh broiler meat obtained from broiler chickens fed three different amounts of probiotics, which were isolated from shubat and koumiss. For the control group, birds were fed a basal diet (BD) and drinking water (DW). Chicks in the experimental groups were fed by BD, DW, and probiotics 0.25 mL, 0.5 mL, a

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Lehman, McKenzie K., Natalie A. Sturd, Fareha Razvi, Dianne L. Wellems, Steven D. Carson, and Paul D. Fey. "Proline transporters ProT and PutP are required for Staphylococcus aureus infection." PLOS Pathogens 19, no. 1 (2023): e1011098. http://dx.doi.org/10.1371/journal.ppat.1011098.

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Proline acquired via specific transporters can serve as a proteinogenic substrate, carbon and nitrogen source, or osmolyte. Previous reports have documented that Staphylococcus aureus, a major community and nosocomial pathogen, encodes at least four proline transporters, PutP, OpuC, OpuD, and ProP. A combination of genetic approaches and 3H-proline transport assays reveal that a previously unrecognized transporter, ProT, in addition to PutP, are the major proline transporters in S. aureus. Complementation experiments using constitutively expressed non-cognate promoters found that proline trans

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He, Yijie, Kwangwook Kim, Cynthia Jinno, et al. "131 Effects of Bacillus spp. probiotics on systemic immunity and intestinal health of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli." Journal of Animal Science 97, Supplement_2 (2019): 74–75. http://dx.doi.org/10.1093/jas/skz122.137.

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Abstract The experiment was conducted to investigate the effects of Bacillus spp. on systemic immunity and intestinal health of weaned pigs infected with F18 E. coli. Weaned pigs (n = 36, 7.61 ± 0.40 kg BW) were randomly allotted to one of three treatments: a control diet and two diets supplemented with 500 mg/kg of Bacillus spp. strain 1 (PRO1) or strain 2 (PRO2). The experiment was conducted for 28 d, including 7 d before and 21 d after the first E. coli inoculation (d 0). The doses of F18 E. coli inoculum were 1010 cfu/3 mL oral dose daily for 3 consecutive days. Serum samples were collecte

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Zhao, Zhi Jun, Ruo Yu Wang, Qian Long Zhao, En Peng Wang, Hai Quan Su, and Shang Hong Zeng. "CuO/CeO₂ and CuO/PrO₂-CeO₂ Catalysts for Preferential Oxidation of CO." Advanced Materials Research 773 (September 2013): 601–5. http://dx.doi.org/10.4028/www.scientific.net/amr.773.601.

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The CuO/CeO2and CuO/PrO2-CeO2catalysts were prepared by the hydrothermal method, and characterized via XRD, SEM and N2adsorption-desorption techniques. The study shows that the BET surface area and pore volume of the CuO/PrO2-CeO2catalysts increase with the increase of praseodymium content. The CuO/CeO2catalyst presents higher catalytic activity in compare with the CuO/PrO2-CeO2catalysts although the addition of praseodymium promotes textural properties of the CuO/CeO2catalysts, and it proves that the interaction of CuO and CeO2has a crucial role in CO-PROX.

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Yamashita, Keisuke, Toshio Shibata, Toshiaki Takahashi, Yuki Kobayashi, and Shun-ichiro Kawabata. "Roles of the clip domains of two protease zymogens in the coagulation cascade in horseshoe crabs." Journal of Biological Chemistry 295, no. 26 (2020): 8857–66. http://dx.doi.org/10.1074/jbc.ra119.012452.

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The lipopolysaccharide (LPS)-triggered coagulation cascade in horseshoe crabs comprises three protease zymogens: prochelicerase C (proC), prochelicerase B (proB), and the proclotting enzyme (proCE). The presence of LPS results in autocatalytic activation of proC to α-chelicerase C, which, in turn, activates proB to chelicerase B, converting proCE to the clotting enzyme (CE). ProB and proCE contain an N-terminal clip domain, but the roles of these domains in this coagulation cascade remain unknown. Here, using recombinant proteins and kinetics and binding assays, we found that five basic residu

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Malod-Dognin, Noël, Gaia Ceddia, Maja Gvozdenov, et al. "A phenotype driven integrative framework uncovers molecular mechanisms of a rare hereditary thrombophilia." PLOS ONE 18, no. 4 (2023): e0284084. http://dx.doi.org/10.1371/journal.pone.0284084.

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Antithrombin resistance is a rare subtype of hereditary thrombophilia caused by prothrombin gene variants, leading to thrombotic disorders. Recently, the Prothrombin Belgrade variant has been reported as a specific variant that leads to antithrombin resistance in two Serbian families with thrombosis. However, due to clinical data scarcity and the inapplicability of traditional genome-wide association studies (GWAS), a broader perspective on molecular and phenotypic mechanisms associated with the Prothrombin Belgrade variant is yet to be uncovered. Here, we propose an integrative framework to a

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Kerry, Matthew J., Thomas Volken, Nikola Biller-Andorno, Andrea Glässel, and Markus Melloh. "A Swiss digital Delphi study on patient-reported outcomes." Swiss Medical Weekly 153, no. 11 (2023): 40125. http://dx.doi.org/10.57187/smw.2023.40125.

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AIMS OF THE STUDY: Health-related quality of life (HRQoL) indicators are patient-reported outcomes (PROs). PROs are defined as any report of the status of a patient’s health condition or health behaviour that comes directly from the patient, without interpretation of the patient’s response by a clinician or anyone else. Despite Swiss national bodies (FOPH, FMH) recognising the potential of PRO measures (PROMs) for improving the health system, no consensus has yet emerged regarding a generic PROM framework or specific domains for practical uptake. The aim of the present digital Delphi study was

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Mutlu, Hatice, Filip E. Du Prez, and C. Remzi Becer. "Introduction to the themed collection on synthetic methodologies for complex macromolecular structures in honour of Prof. Yusuf Yagci's 70^th birthday." Polymer Chemistry 13, no. 11 (2022): 1456–57. http://dx.doi.org/10.1039/d2py90035a.

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Hatice Mutlu, Filip Du Prez and Remzi Becer present the Polymer Chemistry themed collection on synthetic methodologies for complex macromolecular structures in honour of Prof. Yusuf Yagci's 70th birthday.

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Gauthier, M. J., G. N. Flatau, and V. A. Breittmayer. "Protective Effect of Glycine Betaine on Survival of Escherichia coli Cells in Marine Environments." Water Science and Technology 24, no. 2 (1991): 129–32. http://dx.doi.org/10.2166/wst.1991.0043.

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Under marine conditions, Escherichia coli cells develop extensive structural, metabolic and (to some extent) genetic changes which can be considered as adaptive processes rather than the expression of an irreversible decay. Such adaptation strongly depends on the previous history of growth of the cells and on whether they can regulate internal osmotic pressure when entering the sea. All known osmoregulation mechanisms can help the cells to survive at high osmolarity, but their efficiency depends both on expression of genes responsible for osmoregulation and normal functioning of osmoregulatory

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Moysidis, Moysis, Angeliki Chorti, Angeliki Cheva, et al. "L. plantarum UBLP-40 Versus the Combined Formula of L. rhamnosus UBLP-58 and B. longum UBBL-64 in Excisional Wound Healing: A Cellular Perspective." Pharmaceuticals 17, no. 11 (2024): 1414. http://dx.doi.org/10.3390/ph17111414.

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Introduction: The utilization of probiotics in enhancing the active healing of skin wounds represents a burgeoning trend in contemporary medicine. Previous research has extensively explored wound healing mechanisms involving the strains of Lactiplantibacillus plantarum, Lacticaseibacillus rhamnosus, and Bifidobacterium longum. This study seeks to compare and interpret cellular findings derived from immunohistochemical and pathological applications. Methods: Three groups (the control, Lactiplantibacillus plantarum (RO1) group, and Lacticaseibacillus rhamnosus and Bifidobacterium longum (PRO2) g

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Nobels-Janssen, Edith, Philip J. van der Wees, Wim I. M. Verhagen, Gert P. Westert, Ronald H. M. A. Bartels, and Jeroen D. Boogaarts. "Patient-reported outcome measures in subarachnoid hemorrhage." Neurology 92, no. 23 (2019): 1096–112. http://dx.doi.org/10.1212/wnl.0000000000007618.

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ObjectivePatient-reported outcomes (PROs) are aspects of a patient's health status and are considered important for stimulating patient-centered care. Current outcome measures in clinical care for patients with aneurysmal subarachnoid hemorrhage (aSAH) are insufficient to capture PROs. In this systematic review, we aimed to summarize the evidence regarding the quality of patient-reported outcome measures (PROMs) in aSAH patients.MethodsWe performed a systematic review of the literature published from inception until October 29, 2018, in PubMed, the Cochrane Central Register of Controlled Trial

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Rego, Marlon da Silva, Alan Mario Zuffo, Daniel Silva Grespan, et al. "Desempenho agronômico de cultivares de milho segunda safra em Balsas-MA." DELOS: DESARROLLO LOCAL SOSTENIBLE 16, no. 43 (2023): 620–33. http://dx.doi.org/10.55905/rdelosv16.n43-009.

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A identificação de cultivares de milho segunda safra produtivas para Balsas-MA é importante para aumentar a lucratividade do produtor rural dessa cultura. Assim, o objetivo do trabalho foi avaliar o desempenho agronômico de cultivares de milho segunda safra em Balsas-MA. O delineamento experimental utilizado foi o de blocos ao acaso, com 25 cultivares de milho e quatro repetições. Quando a cultura atingiu a fase de maturidade fisiológica, foi avaliado a altura das plantas, a altura de inserção de espiga, o comprimento de espiga, o número de fileiras por espiga, o número de grãos por fileiras,

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Anderson, Lindsay M., Jaclyn L. Papadakis, Anthony T. Vesco, et al. "Patient-Reported and Parent Proxy-Reported Outcomes in Pediatric Medical Specialty Clinical Settings: A Systematic Review of Implementation." Journal of Pediatric Psychology 45, no. 3 (2019): 247–65. http://dx.doi.org/10.1093/jpepsy/jsz082.

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Abstract Objective Youth with chronic illness are at higher risk for psychosocial difficulties, leading to a call for screening via patient-reported outcomes (PROs). The purpose of the current review is to summarize PRO implementation in pediatric medical specialty settings. A literature review of PRO implementation in these settings, conceptual issues, value and approach, legal and ethical concerns, as well as a case example of PROA in type 1 diabetes are presented. Methods A systematic review was conducted to identify relevant articles published since the most recent Journal of Pediatric Psy

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GÖN, Mustafa, and Hüseyin Ersoy. "Translators' Perceptions on Open Source Translation Tools: Trados and OmegaT." International Journal of Linguistics, Literature and Translation 6, no. 5 (2023): 132–44. http://dx.doi.org/10.32996/ijllt.2023.6.5.14.

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In the last century, great technological development has changed the working principles and methods of institutions and professions worldwide and has started a radical innovation process. While it eliminated those who could not keep up with this innovation, it raised those who did to be the best in their fields. One of the professions affected by this change is undoubtedly translation. Translation technology systems are widely used by translators all over the world today and have a large market. Translators' use of translation technologies more effectively and accurately ensures that their tra

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Porto-Gonçalves, Carlos Walter. "ANTROPOCENO OU CAPITALOCENO? A SOCIEDADE NA TRAMA DA VIDA/A TRAMA DA VIDA NA SOCIEDADE." Revista Tamoios 20, no. 2 (2024): 10–22. http://dx.doi.org/10.12957/tamoios.2024.85875.

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Aula Magna no dia 5 de maio de 2022 proferida para os estudantes e docentes do Programa de Pós Graduação em Geografia da UERJ, Faculdade de Formação de Professores. Aula Inaugural do Prog. de Pós-graduação em Geografia-FFP/UERJ - Prof. Carlos Walter Porto-Gonçalves - YouTube

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Liu, Bing, Kohshi Ohishi, Masahiro Masuya, Hirofumi Hamada, and Naoyuki Katayama. "Important Role for flt3 Ligand In the Generation of Early B and T Cell Precursors From Human Primitive Hematopoietic Progenitors, Revealed by Telomerized Human Stromal Cells." Blood 116, no. 21 (2010): 2582. http://dx.doi.org/10.1182/blood.v116.21.2582.2582.

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Abstract Abstract 2582 The regulatory mechanism of human early T and B lymphopoiesis has not been well defined. It has been mostly studied, using mouse stromal cell lines, but either T or B lineage cells were developed. We first tested if human telomerase catalytic subunit (hTERT)-transfected telomerized human stromal cells, which have been shown to efficiently support myelopoiesis in serum-containing and serum-free cultures, are able to support the generation of T and B lineage cells from human primitive hematopoietic progenitors. When we examined the relationship of the expression of lymphoi

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