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Journal articles on the topic 'PRP therapy'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Miroshnychenko, Olga, Wen-teh Chang, and Jason L. Dragoo. "The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration." American Journal of Sports Medicine 45, no. 4 (2016): 945–53. http://dx.doi.org/10.1177/0363546516677547.

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Background: Platelet-rich plasma (PRP) has been used to augment tissue repair and regeneration after musculoskeletal injury. However, there is increasing clinical evidence that PRP does not show a consistent clinical effect. Purpose/Hypothesis: This study aimed to compare the effects of the following non–neutrophil-containing (leukocyte-poor) plasma fractions on human skeletal muscle myoblast (HSMM) differentiation: (1) PRP, (2) modified PRP (Mod-PRP), in which transforming growth factor β1 (TGF-β1) and myostatin (MSTN) were depleted, and (3) platelet-poor plasma (PPP). The hypothesis was that

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LaPrade, Robert F., Laurie R. Goodrich, Jennifer Phillips, et al. "Use of Platelet-Rich Plasma Immediately After an Injury Did Not Improve Ligament Healing, and Increasing Platelet Concentrations Was Detrimental in an In Vivo Animal Model." American Journal of Sports Medicine 46, no. 3 (2017): 702–12. http://dx.doi.org/10.1177/0363546517741135.

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Background: Limited information in basic science and clinical trials exists to determine if ligament healing may be accelerated with the use of biological adjuvants, such as platelet-rich plasma (PRP). However, there has been widespread acceptance of PRP for use in clinical practice, despite an inadequate understanding of its biological mechanism of action. Purpose: To determine whether a single dose of PRP could accelerate ligament healing and correspondingly improve histological characteristics and biomechanical properties when injected immediately postoperatively into the injured medial col

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Yamato, Masayuki, Natsumi Watanabe, and Kazuo Yano. "PRP therapy classification." Regenerative Therapy 2 (December 2015): 1. http://dx.doi.org/10.1016/j.reth.2015.07.001.

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Pitsillidi, Anna, Laura Vona, Stefano Bettocchi, Sven Schiermeier, and Günter Karl Noé. "PRP Therapy for Stress Urinary Incontinence and Pelvic Organ Prolapse: A New Frontier in Personalized Treatment?" Journal of Personalized Medicine 15, no. 6 (2025): 214. https://doi.org/10.3390/jpm15060214.

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Background: Pelvic organ prolapse (POP) and stress incontinence (SUI) are very common medical conditions, affecting women’s quality of life worldwide. Current surgical and conservative therapies often yield variable outcomes and carry risks of complications or recurrence. Platelet-rich plasma (PRP) has emerged as a promising regenerative approach in various medical disciplines. Its application in urogynecology remains relatively new and emerging. The objective of this study was to review and consolidate existing evidence regarding the application of PRP injections for treating POP and/or SUI.

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Godek, Piotr. "High Volume PRP Therapy." Ortopedia Traumatologia Rehabilitacja 24, no. 1 (2022): 43–60. http://dx.doi.org/10.5604/01.3001.0015.7806.

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Background. The PRP method is widely used to support healing and regeneration in musculoskeletal and aesthetic medicine. The current literature, however, brings contradictory reports as to its effectiveness, which, at least in part, should be attributed to the diversity of methods for producing the concentrate, including the use of various volumes of whole blood, single vs double centrifugation vs filtration, use of thrombin vs calcium chloride to activate the process, and, finally, the use of an anticoagulant. The aim of the study was to retrospectively evaluate the effectiveness of high-volu

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Fitzpatrick, Jane, Max Bulsara, and Ming H. Zheng. "The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy: A Meta-analysis of Randomized Controlled Clinical Trials." American Journal of Sports Medicine 45, no. 1 (2016): 226–33. http://dx.doi.org/10.1177/0363546516643716.

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Background: Tendinopathy is very common in the general population. There are increasing numbers of clinical studies referring to platelet-rich plasma (PRP) and platelet-poor plasma (PPP) as treatments for tendinopathy. Purpose: To perform a meta-analysis of the outcomes of the PRP groups by preparation method and injection technique in tendinopathy. To determine the clinical effectiveness of the preparations and to evaluate the effect of controls used in the studies reviewed. Study Design: Systematic review and meta-analysis. Methods: The PubMed, EMBASE, CINAHL, and Medline databases were sear

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Beitia, Maider, Diego Delgado, Jon Mercader, Pello Sánchez, Leonor López de Dicastillo, and Mikel Sánchez. "Action of Platelet-Rich Plasma on In Vitro Cellular Bioactivity: More than Platelets." International Journal of Molecular Sciences 24, no. 6 (2023): 5367. http://dx.doi.org/10.3390/ijms24065367.

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Platelet-rich plasma (PRP) is a biological therapy in which one of the mechanisms of action is the stimulation of biological processes such as cell proliferation. The size of PRP’s effect depends on multiple factors, one of the most important being the composition of PRP. The aim of this study was to analyze the relationship between cell proliferation and the levels of certain growth factors (IGF-1, HGF, PDGF, TGF-β and VEG) in PRP. First, the composition and effect on cell proliferation of PRP versus platelet-poor plasma (PPP) were compared. Subsequently, the correlation between each growth f

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Nithyanandham Masilamani and Dhanraj Ganapathy. "Awareness about Regenerative Therapy with of Platelet Rich Plasma (PRP) among Dental Students." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (2020): 962–66. http://dx.doi.org/10.26452/ijrps.v11ispl3.3058.

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Platelet Rich Plasma(PRP), serving as a vehicle and wellspring of development factors, is a homologous plasma formulation with congregated platelets broadly studied for its applications as a scaffold in cell-based intervention and tissue engineering. The aim of the study was to assess the awareness about regenerative therapy with platelet Rich Plasma (PRP) among dental students. A cross-sectional study was done with a self-administered questionnaire with ten questions circulated among 100 dental students. The questionnaire assessed the awareness about PRP regenerative therapy in surgical appli

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Rosso, Claudio, Mark E. Morrey, Michael O. Schär, et al. "The role of platelet-rich plasma in shoulder pathologies: a critical review of the literature." EFORT Open Reviews 8, no. 4 (2023): 213–22. http://dx.doi.org/10.1530/eor-22-0104.

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Platelet-rich plasma (PRP) is a revolutionary treatment that harnesses the regenerative power of the body's own platelets to promote healing and tissue regeneration. While PRP therapy has emerged as a promising option for augmenting biologic healing in the shoulder, the complexity of shoulder disorders makes it difficult to draw definitive conclusions about the efficacy of PRP across different conditions and stages of disease. Our comprehensive review of twenty-four studies highlights the current state of PRP therapy in shoulder pathologies, revealing a wide variety of number of patients, cont

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Pakhomova, Elena E., and Irina O. Smirnova. "Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia." International Journal of Molecular Sciences 21, no. 18 (2020): 6516. http://dx.doi.org/10.3390/ijms21186516.

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Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) cells in skin biopsy. Materials and Methods: The study involved 69 men who were divided into 3 groups who received PRP therapy, minoxidil, and their combination. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric of hairs.

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Segabinazzi, Lorenzo G. T. M., Igor F. Canisso, Giorgia Podico, et al. "Intrauterine Blood Plasma Platelet-Therapy Mitigates Persistent Breeding-Induced Endometritis, Reduces Uterine Infections, and Improves Embryo Recovery in Mares." Antibiotics 10, no. 5 (2021): 490. http://dx.doi.org/10.3390/antibiotics10050490.

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Microorganisms, including pathogenic or opportunistic bacteria and fungi, may gain access to the uterus during breeding, and infectious endometritis plays a major role in equine subfertility. This study aimed to assess the post-breeding inflammatory response, endometrial culture, and embryo recovery of mares susceptible to persistent breeding-induced endometritis (PBIE) treated with plasma-rich (PRP) or -poor (PPP) plasma. Mares (n = 12) susceptible to PBIE had three cycles randomly assigned to receive intrauterine infusions of lactate ringer solution (LRS, control), or autologous PRP or PPP p

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Pooja, Priyam, Shikha, and Kumar Vikas. "Comparative Study of Platelet-Rich Plasma Vs Corticosteroid Injection for Plantar Fasciitis, Bihar, India." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 1618–21. https://doi.org/10.5281/zenodo.11085641.

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<strong>Background</strong><strong>:</strong> Plantar fasciitis is a prevalent source of heel pain, affecting individuals worldwide. Treatment options often include corticosteroid injections, known for their short-term pain relief, and Platelet-Rich Plasma (PRP) therapy, which aims for long-term benefits through tissue regeneration. The study aims to conduct a comparative study assessing the efficacy and safety of PRP injection therapy versus corticosteroid injection therapy for the management of plantar fasciitis in patients. <strong>Methods:</strong> The retrospective comparat

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Yesmeen, Dr Maruna, and Dr Farhana Haque. "Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination in the Treatment of Men with Androgenetic Alopecia." Scholars Journal of Applied Medical Sciences 12, no. 08 (2024): 1086–91. http://dx.doi.org/10.36347/sjams.2024.v12i08.027.

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Background: Platelet-rich plasma (PRP) therapy holds promise as a treatment for androgenetic alopecia (AGA). This study aimed to compare the clinical efficacy of PRP therapy, minoxidil, and their combination in treating men with AGA, and to evaluate PRP's effects on hair follicle (HF) cell proliferation via skin biopsy. Materials and Methods: This prospective study was carried out at tertiary hospital from June 2021 to June 2022. A total of 69 men were divided into three groups: PRP therapy, minoxidil, and combined therapy. Clinical efficacy was assessed through hair morphometrics, while cell

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Thursina, Cempaka, Imeinar Anggita Wulandari, Hanik Badriyah Hidayati, Ahmad Nur Fikri Abror, Vania Ayu Puspamaniar, and Abdul Gofir. "Platelet rich plasma therapy for carpal tunnel syndrome." Anaesthesia, Pain & Intensive Care 28, no. 6 (2024): 1128–31. https://doi.org/10.35975/apic.v28i6.2615.

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Carpal tunnel syndrome (CTS) is the most frequent peripheral nerve entrapment neuropathy, accounting for about 90% of cases. CTS arises because of the median nerve compression in the carpal tunnel on the wrist, as the median nerve passes through the tunnel from the forearm to the hand. The available evidence regarding therapy for CTS, reveals that splinting therapy, corticosteroid injection, and surgery are not 100% effective in curing CTS so there is a need to search for other alternative therapies. One of the pain therapies currently being developed in the medicine sector is platelet rich pl

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Flahive, S. "Platelet Rich Plasma therapy–PRP." Journal of Science and Medicine in Sport 15 (December 2012): S135—S136. http://dx.doi.org/10.1016/j.jsams.2012.11.327.

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Zhang, Yao-Hua, Youwen Zhou, Nigel Ball, Ming-Wan Su, Jin-Hua Xu та Zhi-Zhong Zheng. "Type I Pityriasis Rubra Pilaris: Upregulation of Tumor Necrosis Factor α and Response to Adalimumab Therapy". Journal of Cutaneous Medicine and Surgery 14, № 4 (2010): 185–88. http://dx.doi.org/10.2310/7750.2010.09023.

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Background: Pityriasis rubra pilaris (PRP) has unknown etiology and is often refractory to conventional therapies. Objective: To document a PRP patient's response to adalimumab therapy and to highlight the potential role of tumor necrosis factor (TNF) in the development of PRP skin lesions. Methods: A patient received adalimumab therapy at standard dosing intervals. In addition, the messenger ribonucleic acid (mRNA) of TNF in the lesional and perilesional normal skin was quantified in two patients with PRP. Results: The patient responded to adalimumab therapy and achieved clinical remission by

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Di Mitri, Marco, Simone D’Antonio, Edoardo Collautti, et al. "Platelet-Rich Plasma in Pediatric Surgery: A Comprehensive Review." Children 11, no. 8 (2024): 971. http://dx.doi.org/10.3390/children11080971.

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Platelet-Rich Plasma (PRP) therapy has become a promising treatment option in pediatric surgery, offering a novel approach to tissue repair and regeneration. Obtained from the patient’s own blood or umbilical cord blood (CB), PRP is a concentrated form of plasma enriched with platelets, growth factors, and cytokines essential for stimulating tissue healing. This systematic review explores the applications of PRP therapy in pediatric surgical procedures, focusing on its role in promoting wound healing, reducing postoperative complications, and enhancing patient outcomes. A systematic literature

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Jo, Chris Hyunchul, Seung Yeon Lee, Kang Sup Yoon та Sue Shin. "Effects of Platelet-Rich Plasma With Concomitant Use of a Corticosteroid on Tenocytes From Degenerative Rotator Cuff Tears in Interleukin 1β–Induced Tendinopathic Conditions". American Journal of Sports Medicine 45, № 5 (2017): 1141–50. http://dx.doi.org/10.1177/0363546516681294.

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Background: A corticosteroid injection is commonly used to treat tendinopathy, but it has been associated with negative effects on tendon homeostasis. Platelet-rich plasma (PRP) is known to have proliferative and anabolic effects as well as cytoprotective effects against corticosteroids on tenocytes. However, the combined effects of a corticosteroid and PRP on the anti-inflammatory, matrix synthesis, and cytoprotective potential of tenocytes in conditions simulating tendinopathy have not been investigated. Purpose: To assess the effects of PRP on tenocytes from degenerative rotator cuff tears

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Mercer, Joshua M., Chitra Pushpanthan, Canagasundrum Anandakrishnan, and Ian D. R. Landells. "Familial Pityriasis Rubra Pilaris: Case Report and Review." Journal of Cutaneous Medicine and Surgery 17, no. 4 (2013): 226–32. http://dx.doi.org/10.2310/7750.2012.12018.

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Background: Pityriasis rubra pilaris (PRP) is a rare dermatosis of unknown etiology. Most cases of PRP are sporadic; however, rare cases of familial PRP have been reported. Objectives: To present a case of PRP inherited in an autosomal dominant (AD) fashion and to evaluate the current literature on familial PRP and formulate a comprehensive, up-to-date summary of this rare condition. Methods: PubMed was used to conduct a search for articles pertaining to familial PRP published through May 2011. Results: The first documented case was published in 1910, and 36 subsequent familial cases of PRP ha

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Ball, Gretchen, Scott Stratman, and Alice B. Gottlieb. "A Case of Pityriasis Rubra Pilaris Following Atorvastatin Therapy." SKIN The Journal of Cutaneous Medicine 9, no. 4 (2025): 2513–17. https://doi.org/10.25251/y4xyeh76.

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Background: Pityriasis rubra pilaris (PRP) is a rare dermatologic disorder of unknown etiology characterized by distinct red-orange scaly plaques, red follicular papules, and palmoplantar keratoderma. The occurrence of PRP following statin therapy is exceptionally uncommon, with only a few cases reported in the literature. Case Presentation: An 83-year-old male developed PRP within one month of initiating atorvastatin therapy. Detailed history revealed no other new medications or identifiable triggers. Initially misdiagnosed with psoriasis, the patient underwent multiple biopsies and several u

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Simoncic, Boris, Maja Dimitrijevic, Jelena Juloski, and Zoran Vulicevic. "The use of adipose-derived stem cells, platelet-rich and platelet-poor plasma in the maxillary cyst treatment." Srpski arhiv za celokupno lekarstvo, no. 00 (2022): 89. http://dx.doi.org/10.2298/sarh220505089s.

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Introduction. The case report describes the effect of combination therapy using adipose-derived stem cells (ADSC), platelet-rich plasma (PRP) and platelet-poor plasma (PPP) in the treatment of a maxillary cyst. Case outline. A maxillary cyst between the central incisors was identified in a healthy 54-year-old male patient during a routine dental check-up. Following thorough clinical and radiographic examinations, the treatment plan was presented and explained to the patient and written informed consent was obtained. Initially, the conservative periodontal treatment was performed. Afterwards, t

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Devina, Subagio, and Fawzy Ahmad. "Reviewing and Exploring the Prospects of Platelet-Rich Plasma (PRP) Therapy in the Context of Pediatric Surgical Wound Management." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 08 (2023): 1770–81. https://doi.org/10.5281/zenodo.8308155.

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Pediatric surgical wound care is a critical aspect of medical practice, necessitating innovative approaches to optimize healing and minimize complications. Platelet-rich plasma (PRP) therapy has emerged as a promising intervention for enhancing wound healing in pediatric patients. This review comprehensively evaluates the efficacy, underlying mechanisms, and challenges associated with platelet-rich plasma (PRP) therapy in the context of pediatric surgical wounds.   Platelet-rich plasma (PRP), a biologic concentrate enriched with growth factors and cytokines, plays a pivotal role in wound

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Wijekoon, H. M. Suranji, and D. D. Niranjala de Silva. "Current Evidence on Using Platelet Rich Plasma as a Therapeutic Modality for Veterinary Orthopedic Conditions." World's Veterinary Journal 11, no. 1 (2021): 73–78. http://dx.doi.org/10.54203/scil.2021.wvj10.

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This review evaluates the findings of available clinical literature on the use of platelet-rich plasma (PRP) to develop evidence-based recommendations for treating various musculoskeletal issues that arise in veterinary practice. The use of PRP-based treatments for various orthopedic conditions is rapidly evolving as a promising treatment modality; however, its true effectiveness has yet to be elucidated. Application of PRP has been reported in humans for a variety of orthopedic conditions. Although the majority of the veterinary literature on PRP reports its use in equine patients, there is a

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Chilmawati, Laili, Agung Dewanto, Muhammad Lutfi, and Lukman Ade Chandra. "Clinical benefits of platelet rich plasma therapy in thin endometrium: A systematic review and meta-analysis." Bali Medical Journal 14, no. 1 (2024): 99–104. https://doi.org/10.15562/bmj.v14i1.5376.

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Introduction: Endometrium is one of the primary components of embryo to implant. Adequate endometrium is necessary for embryo to implant successfully. Inadequate endometrium increased the probability of unsuccessful embryonic implantation attempt. Platelet rich plasma (PRP) was recently proposed as therapy option for thin endometrium. The study aimed at evaluating the clinical benefits of PRP therapy by examining the impact the PRP therapy on the thickness of endometrium, chemical and clinical pregnancy rates. Methods: Recovered randomized controlled trial (RCT) was subjected to investigationa

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Kawabata, Soya, Koji Akeda, Junichi Yamada, et al. "Advances in Platelet-Rich Plasma Treatment for Spinal Diseases: A Systematic Review." International Journal of Molecular Sciences 24, no. 8 (2023): 7677. http://dx.doi.org/10.3390/ijms24087677.

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Spinal diseases are commonly associated with pain and neurological symptoms, which negatively impact patients’ quality of life. Platelet-rich plasma (PRP) is an autologous source of multiple growth factors and cytokines, with the potential to promote tissue regeneration. Recently, PRP has been widely used for the treatment of musculoskeletal diseases, including spinal diseases, in clinics. Given the increasing popularity of PRP therapy, this article examines the current literature for basic research and emerging clinical applications of this therapy for treating spinal diseases. First, we revi

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Rudyan, Jemie, I. Wayan Suryanto Dusak, I. Gusti Ngurah Wien Aryana та Elysanti Dwi Mertadiani. "The Differences in Western Ontario Rotator Cuff Scores and Transforming Growth Factor-Β Levels Between the use of Platelet Rich Plasma Therapy and Non-Platelet Rich Plasma Therapy in the Conservative Management of Patients with Partial Rotator Cuff Injury". International Journal of Research and Review 12, № 5 (2025): 665–72. https://doi.org/10.52403/ijrr.20250570.

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Introduction: Partial rotator cuff injuries are a major cause of shoulder pain and significant functional impairment. Conservative therapy with physiotherapy and steroid injections is commonly used but has limitations in long-term effectiveness. Platelet Rich Plasma (PRP) has emerged as an alternative therapy with the potential to accelerate healing through regenerative and anti-inflammatory mechanisms. However, the effectiveness of PRP in improving shoulder function and Transforming Growth Factor-β (TGF-β) levels in patients with partial rotator cuff injuries still needs further investigation

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Araya, Naoko, Kazumasa Miyatake, Kunikazu Tsuji, et al. "Intra-articular Injection of Pure Platelet-Rich Plasma Is the Most Effective Treatment for Joint Pain by Modulating Synovial Inflammation and Calcitonin Gene-Related Peptide Expression in a Rat Arthritis Model." American Journal of Sports Medicine 48, no. 8 (2020): 2004–12. http://dx.doi.org/10.1177/0363546520924011.

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Background: Platelet-rich plasma (PRP) has emerged as a treatment for osteoarthritis (OA). However, the effect that leukocyte concentrations in PRP have on OA remains unclear. Purpose: To clarify the optimal PRP formulation for OA treatment by comparing pure PRP, leukocyte-poor PRP (LP-PRP), and leukocyte-rich PRP (LR-PRP) in a rat arthritis model. Study Design: Controlled laboratory study. Methods: Knee arthritis was induced bilaterally in male Wistar rats with intra-articular injections of monosodium iodoacetate (MIA) on day 0. Rats were randomly assigned to 1 of 3 treatment groups (pure PRP

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Ramsook, Ryan Ravi. "Timing of Platelet Rich Plasma Injections During Antithrombotic Therapy." Pain Physician 7;19, no. 7;9 (2016): E1055—E1061. http://dx.doi.org/10.36076/ppj/2016.19.e1055.

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The use of platelet rich plasma (PRP) spans across many fields owing to its role in healing and as a natural alternative to surgery. PRP continues to grow however much of the literature is anecdotal or case report based and there is a lack of controlled trials to evaluate standards for PRP. The International Cellular Medical Society (ICMS) has developed guidelines to help with the safe advancement of PRP; however there remains a gap in literature concerning the timing of PRP injections in patients who are on antithrombotic therapy. The importance of an intact platelet surface membrane allows f

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Saleena, Resheed, and V. Samson Shalini. "A Review of Platelet Rich Plasma Therapy Used Obstetrics and Gynaecology." Research & Reviews: Journal of Nursing in Women's Health and Midwifery 1, no. 1 (2025): 21–24. https://doi.org/10.5281/zenodo.14863654.

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<em>Platelet-Rich Plasma (PRP) Therapy in Obstetrics and Gynaecology: A Promising Treatment Approach. PRP therapy has emerged as a novel treatment approach in various medical fields, including Obstetrics and Gynaecology. PRP therapy has shown promising results in improving ovarian function, endometrial thickness, and menstrual health in women with various reproductive disorders. The therapy has also been effective in enhancing fertility outcomes and reducing symptoms of Asherman's syndrome.</em>

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Charliyan, Gary. "PRP Therapy for the Treatment of Sacral Fracture and Coccydynia: A Case Report." Pain Medicine Case Reports 7, no. 6 (2023): 285–92. http://dx.doi.org/10.36076/pmcr.2023.7.285.

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BACKGROUND: Platelet-rich plasma (PRP) therapy has shown promising results in promoting healing and reducing inflammation in musculoskeletal injuries. This case report highlights the successful use of PRP injection therapy in a 37-year-old woman pedestrian with a sacral fracture and coccydynia from a pedestrian-vehicle accident. CASE REPORT: The patient underwent traversing sacral S3 anterior cortex vertebral fracture and sacrococcygeal PRP injection under fluoroscopic guidance. PRP injection therapy led to significant improvement in tailbone pain, and subsequent injection led to further impro

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Jiang, Guangyao, Yifan Wu, Jiahong Meng, et al. "Comparison of Leukocyte-Rich Platelet-Rich Plasma and Leukocyte-Poor Platelet-Rich Plasma on Achilles Tendinopathy at an Early Stage in a Rabbit Model." American Journal of Sports Medicine 48, no. 5 (2020): 1189–99. http://dx.doi.org/10.1177/0363546520906142.

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Background: Tendinopathy is still a great challenge in clinical practice, and the role of platelet-rich plasma (PRP) is controversial. The influence of leukocytes on tendinopathy at an early stage has not been defined so far. Purpose: To compare the effects of leukocyte-rich PRP (Lr-PRP) and leukocyte-poor PRP (Lp-PRP) on Achilles tendinopathy when applied at an early stage. Study Design: Controlled laboratory study. Methods: A rabbit Achilles tendinopathy model was induced by a collagenase injection. A week later, treatments were applied randomly on local Achilles tendon lesions: (1) 200 μL o

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Gonzalez, Maczy, Melvis Arteaga-Vizcaino, Ana Ruiz, et al. "Growth Factors in the Platelet-Rich Plasma." Journal of Hematology Research 4 (February 27, 2017): 9–18. http://dx.doi.org/10.12974/2312-5411.2017.04.2.

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PRP is an useful bioproduct to tisular regeneration. The aim of study was evaluate the concentration of growth factors: PDGFBB (platelet-derived growth factor), EGF(epidermal growth factor) and VEGF (vascular endothelial growth factor) present in the Platelet-rich plasma (PRP) in subjects treated with drugs which inhibit platelet aggregation as acetylsalicylic acid (ASA) and clopidogrel before and after administration. We determined by ELISA PDGFBB, EGF and VEGF levels in PRP, Platelet Poor Plasma (PPP), lysate and exudate from 32 healthy subjects before and 24 hours after ingesting acid Acety

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Kaiser, Michael A., Lina M. Ferrari, Simonetta I. Gaumond, Najy Issa, Joaquin J. Jimenez, and Naiem T. Issa. "Platelet rich plasma combination therapies for treatment of androgenetic alopecia: A systematic review." Journal of Cutaneous and Aesthetic Surgery 16, no. 3 (2023): 169–77. http://dx.doi.org/10.4103/jcas.jcas_206_22.

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Abstract Androgenetic alopecia (AGA) is the most common cause of alopecia in males and females. Minoxidil and finasteride are the only FDA-approved treatments for AGA. New treatments including Platelet Rich Plasma (PRP) and microneedling have shown promising results. The purpose of this literature review was to highlight recent studies examining the effects of topical minoxidil combined with PRP to minoxidil or PRP monotherapy. The method used for this paper includes a systematic review of the literature from 2010 to 2022 using the PubMed, EMBASE, and MEDLINE databases examining studies evalua

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Maniaci, Antonino, Salvatore Lavalle, Edoardo Masiello, et al. "Platelet-Rich Plasma (PRP) in the Treatment of Long COVID Olfactory Disorders: A Comprehensive Review." Biomedicines 12, no. 4 (2024): 808. http://dx.doi.org/10.3390/biomedicines12040808.

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Background: Long COVID has brought numerous challenges to healthcare, with olfactory dysfunction (OD) being a particularly distressing outcome for many patients. The persistent loss of smell significantly diminishes the affected individual’s quality of life. Recent attention has been drawn to the potential of platelet-rich plasma (PRP) therapy as a treatment for OD. This comprehensive review aims to evaluate the effectiveness of PRP therapy in ameliorating OD, especially when associated with long-term COVID-19. Methods: We executed a comprehensive search of the literature, encompassing clinica

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Zhang, Ning, Yong-Ping Wu, Sheng-Jun Qian, Chong Teng, Shuai Chen, and Hang Li. "Research Progress in the Mechanism of Effect of PRP in Bone Deficiency Healing." Scientific World Journal 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/134582.

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Platelet-rich plasma (PRP) therapy is a recently developed technique that uses a concentrated portion of autologous blood to try to improve and accelerate the healing of various tissues. There is a considerable interest in using these PRP products for the treatment used in bone deficiency healing. Because PRP products are safe and easy to prepare and administer, there has been increased attention toward using PRP in numerous clinical settings. The benefits of PRP therapy appear to be promising, and many investigators are exploring the ways in which this therapy can be used in the clinical sett

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Chiu, Chih-Hao, Rei Higashikawa, Wen-Ling Yeh, Kin Lei, and Alvin Chen. "Investigation of Growth Factor and Tenocyte Proliferation Induced by Platelet Rich Plasma (PRP) in a 3-Chamber Co-Culture Device." Micromachines 9, no. 9 (2018): 446. http://dx.doi.org/10.3390/mi9090446.

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The platelet-rich plasma (PRP) has become an attractive topic for soft tissue healing therapy recently. While some clinical reports revealed the effective treatments for knee osteoarthritis, lateral epicondylitis, and rotator cuff tears, other case studies showed that there was no statistically significant healing improvement. The efficacy of the PRP therapy is still unclear clinically. Thus, a significant amount of basic studies should be conducted to optimize the preparation procedure and the platelet concentration of the PRP. In this work, a 3-chamber co-culture device was developed for the

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Bondarenko, Ruslan V., Sergey B. Bezshapochnyy, Mychailo I. Bezega, et al. "Influence of pallet rich plasma, quercetin and their combination on activity of nitric oxide cycle enzymes in nasal mucosa of patients with atrophic rhinitis." Polski Merkuriusz Lekarski 52, no. 1 (2024): 17–22. http://dx.doi.org/10.36740/merkur202401103.

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https://polskimerkuriuszlekarski.pl/wp-content/uploads/library/PolMerkurLek2024i1.pdf , ,, , , , Aim: To study the general activity of NO synthases (gNOS), the activity of inducible and constitutive isoforms of NO synthase, the activity of arginases, and the concentration of nitrites in the nasal mucosa under the conditions of local treatment of chronic atrophic rhinitis (AR) with quercetin and platelet-rich plasma (PRP therapy). Materials and Methods: The study was conducted on 118 patients divided into two groups: control (n=20) and experimental (patients with AR, n=98). Experimental group w

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Muir, Sean M., Natalie Reisbig, Michael Baria, Christopher Kaeding, and Alicia L. Bertone. "The Concentration of Plasma Provides Additional Bioactive Proteins in Platelet and Autologous Protein Solutions." American Journal of Sports Medicine 47, no. 8 (2019): 1955–63. http://dx.doi.org/10.1177/0363546519849671.

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Background: Currently, platelet-poor plasma (PPP) is a discarded waste product of platelet-rich plasma (PRP) and may contain valuable proteins. Purpose/Hypothesis: The study’s goal was to evaluate the concentration of plasma as a potential additive biotherapy for the treatment of osteoarthritis. We hypothesized that a novel polyacrylamide concentration device would efficiently concentrate insulin-like growth factor–1 (IGF-1) from PPP and be additive to PRP or autologous protein solution (APS). Study Design: Descriptive laboratory study. Methods: A laboratory study was conducted with human and

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Gazizova, G. Kh, A. G. Yashchuk, A. V. Maslennikov, L. A. Dautova, and G. Yu Battalova. "Evaluation of the efficacy of different treatment modalities for chronic atrophic endometritis." Voprosy ginekologii, akušerstva i perinatologii 21, no. 4 (2022): 152–58. http://dx.doi.org/10.20953/1726-1678-2022-4-152-158.

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Objective. To study the efficacy of different treatment regimens in patients with chronic atrophic endometritis against the background of endometrial hemodynamic dysfunction using intrauterine perfusion of platelet-rich plasma (PRP therapy) or sulodexide, or a combination of PRP therapy and sulodexide. Patients and methods. This study included 116 patients with morphologically confirmed diagnosis of chronic endometritis. Patients were divided into three groups: group 1 (n = 18) received PRP therapy in addition to basic therapy; group 2 (n = 68) received basic therapy and sulodexide; group 3 (n

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Janocha, Aleksandra, Aneta Jerzak, Anna Hitnarowicz, Bożena Kmak, Anna Szot, and Agnieszka Pociecha. "Platelet-rich plasma as a new treatment method in orthopedics." Journal of Education, Health and Sport 67 (May 12, 2024): 49195. http://dx.doi.org/10.12775/jehs.2024.67.49195.

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Introduction and purposePlatelet-rich plasma (PRP) therapy represents a technology designed to enhance tissue repair by locally administering one's own bioactive agents, aiming to influence physiological processes like inflammation, angiogenesis, and extracellular matrix synthesis. Recently, the use of PRP therapy has become a subject of discussion in the orthopedic field. This review comprehensively examines the mechanisms, contemporary applications, clinical evidence, safety aspects, and potential future advancements of PRP in orthopedic treatment. Research has documented the efficacy of PRP

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Sertakova, A. V., V. Yu Ulyanov, and Eh A. Magomedrasulova. "PROSPECTS FOR PLATELET-RICH PLASMA THERAPY IN PEDIATRICS." Pediatria. Journal named after G.N. Speransky 101, no. 6 (2022): 152–57. http://dx.doi.org/10.24110/0031-403x-2022-101-6-152-157.

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From the point of view of the characteristics of childhood and clinical and pathophysiological features of diseases in children, the injections of platelet-rich plasma (PRP) are an advantageous manipulation procedures characterized by minimal invasiveness, minimal risk of side effects, ease of obtaining material and manipulation technique, as well as the uselessness of anesthesia. The purpose of this research was to analyze the use and possible effectiveness of PRP therapy in pediatric practice and its application, in particular, in traumatology and orthopedics. The bibliographical search for

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Ekta Jain, Saurabh Saxena, Ajay Pathak, et al. "Comparison between negative pressure wound therapy and platelet-rich plasma therapy in management of diabetic foot." Asian Journal of Medical Sciences 15, no. 12 (2024): 187–92. https://doi.org/10.71152/ajms.v15i12.4301.

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Background: Foot infections and ulceration are the most frequent reason for hospitalization in patients with diabetes mellitus (DM), accounting for up to 25% of all patients with DM admission. In the new advanced therapies for treating diabetic foot ulcers (DFUs), platelet-rich plasma (PRP) and negative pressure wound therapy (NPWT) have shown promising results. Aims and Objectives: The objectives of the study are as follows: To study the role of NPWT and PRP in management diabetic foot wounds and to compare granulation tissue formation, total duration of wound healing, and hospital stay betwe

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Ekta Jain, Saurabh Saxena, Ajay Pathak, et al. "Comparison between negative pressure wound therapy and platelet-rich plasma therapy in management of diabetic foot." Asian Journal of Medical Sciences 15, no. 12 (2024): 187–92. https://doi.org/10.3126/ajms.v15i12.70745.

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Background: Foot infections and ulceration are the most frequent reason for hospitalization in patients with diabetes mellitus (DM), accounting for up to 25% of all patients with DM admission. In the new advanced therapies for treating diabetic foot ulcers (DFUs), platelet-rich plasma (PRP) and negative pressure wound therapy (NPWT) have shown promising results. Aims and Objectives: The objectives of the study are as follows: To study the role of NPWT and PRP in management diabetic foot wounds and to compare granulation tissue formation, total duration of wound healing, and hospital stay betwe

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Di Martino, Alessandro, Angelo Boffa, Luca Andriolo, et al. "Leukocyte-Rich versus Leukocyte-Poor Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Trial." American Journal of Sports Medicine 50, no. 3 (2022): 609–17. http://dx.doi.org/10.1177/03635465211064303.

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Background: Platelet-rich plasma (PRP) is gaining large interest in clinical practice as a minimally invasive injective treatment for knee osteoarthritis (OA). Different preparation methods are available, and the presence of leukocytes, deemed detrimental in some preclinical studies, is one of the most debated aspects regarding PRP efficacy. Purpose: To compare the safety and effectiveness of leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP (LP-PRP) for the treatment of knee OA. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 192 patients with symptomatic

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Everhart, Joshua S., Parker A. Cavendish, Alex Eikenberry, Robert A. Magnussen, Christopher C. Kaeding, and David C. Flanigan. "Platelet-Rich Plasma Reduces Failure Risk for Isolated Meniscal Repairs but Provides No Benefit for Meniscal Repairs With Anterior Cruciate Ligament Reconstruction." American Journal of Sports Medicine 47, no. 8 (2019): 1789–96. http://dx.doi.org/10.1177/0363546519852616.

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Background: The effect of platelet-rich plasma (PRP) on the risk of meniscal repair failure is unclear. Current evidence is limited to small studies without comparison between isolated repairs and meniscal repairs with concomitant anterior cruciate ligament (ACL) reconstruction. It is also unclear whether the efficacy of PRP differs between preparation systems in the setting of meniscal repair. Purpose: (1) To determine whether intraoperative PRP affects the risk of meniscal repair failure. (2) To determine whether the effect of PRP on meniscal failure risk is influenced by ACL reconstruction

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Rao, Ashwath, Manikanta K. S., and Mir Md Noorul Hassan. "Plasma or Fibrin Matrix? A Comparative Study between PRP versus PRFM Therapy in Diabetic Foot Ulcer." New Indian Journal of Surgery 14, no. 3 (2023): 9–14. http://dx.doi.org/10.21088/nijs.0976.4747.14323.1.

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Introduction: Diabetic foot ulcer is one of the most common conditions encountered in surgical OPD. The incidence of a diabetic foot ulcer is around 15% among the diabetic population. Around 80% of non-traumatic amputation is due to chronic diabetic foot ulcer. Recent advances are made in treating wounds in which platelet-rich plasma (PRP) and platelet rich fibrin matrix (PRFM) therapy have proven beneficial. Materials and Methods: A prospective study was conducted from February 2021 to February 2023, for a period of 2 years which included 42 patients. Group A received autologous platelet rich

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Tsai, Wen-Chung, Tung-Yang Yu, Gwo-Jyh Chang, et al. "Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries." American Journal of Sports Medicine 49, no. 11 (2021): 3102–12. http://dx.doi.org/10.1177/03635465211030295.

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Background: The increasing use of platelet-rich plasma (PRP) to treat muscle injuries raises concerns because transforming growth factor–beta (TGF-β) in PRP may promote fibrosis in the injured muscle and thus impair muscle regeneration. Purpose: To investigate whether suramin (a TGF-β inhibitor) can reduce muscle fibrosis to improve healing of the injured muscle after PRP treatment and identify the underlying molecular mechanism. Study Design: Controlled laboratory study. Methods: Myoblasts isolated from the gastrocnemius muscle of Sprague Dawley rats were treated with PRP or PRP plus suramin.

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Gorodilova, Anna V., Chulpan B. Kharisova, Maria N. Osinnikova, et al. "The Well-Forgotten Old: Platelet-Rich Plasma in Modern Anti-Aging Therapy." Cells 13, no. 21 (2024): 1755. http://dx.doi.org/10.3390/cells13211755.

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Currently, approaches to personalized medicine are actively developing. For example, the use of platelet-rich plasma (PRP) is actively growing every year. As a result of activation, platelets release a wide range of growth factors, cytokines, chemokines, and angiogenic factors, after which these molecules regulate chemotaxis, inflammation, and vasomotor function and play a crucial role in restoring the integrity of damaged vascular walls, angiogenesis, and tissue regeneration. Due to these characteristics, PRP has a wide potential in regenerative medicine and gerontology. PRP products are acti

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Machaj, Damian, Aleksandra Mazurek, Dominik Machaj, and Wiktoria Józefowicz. "The Role of Platelet-Rich Plasma Therapy in Treating Sports Injuries." Quality in Sport 25 (October 12, 2024): 54905. http://dx.doi.org/10.12775/qs.2024.24.54905.

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Introduction: Sports injuries are a significant health problem for both professional and recreational athletes. Standard treatment methods, including physiotherapy, pharmacotherapy, and surgical interventions, often fall short in cases of severe soft tissue damage. This has led to a growing interest in alternative therapies, such as platelet-rich plasma (PRP). In recent years, there has been growing interest in platelet-rich plasma (PRP) therapy due to its potential regenerative properties. PRP is increasingly used in the treatment of sports injuries, with the aim of accelerating tissue regene

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Thomas, Joanna, Devpal Patil Jayaditya, Dallal Wessam Al, and Anastasia Athanasiou. "Evaluating the Effectiveness of Intra-articular Platelet Rich Plasma Injections for the Treatment of Knee Osteoarthritis: A Systematic Review." SVOA Orthopaedics 3, no. 2 (2023): 31–41. https://doi.org/10.58624/SVOAOR.2023.03.041.

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Introduction: Osteoarthritis (OA) is the most frequently presented joint disorder, and its treatment is often challenging. Current literature has controversial results regarding the efficacy of Platelet Rich Plasma therapy (PRP) when compared to placebo injections. This systematic review investigates the role of intra-articular PRP injections as a recommended treatment option for knee OA with the potential to establish appropriate guidelines for treating physicians. Method: This review used PUBMED, Cochrane and CINHAL database. A thorough review of literature examining PRP injections as treatm

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