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Dissertations / Theses on the topic 'Prp45'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Robert-Paganin, Julien. "Étude structurale et fonctionnelle de la régulation de l’hélicase Prp43." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P633/document.

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Les hélicases à ARN de la famille DEAH/RHA sont impliquées dans la plupart des processus essentiels à la vie tels que l'épissage, la biogenèse des ribosomes, la réplication, la transcription ou encore la détection d’ARN viraux. Ces enzymes sont capables de catalyser la dissociation de duplexes d'ARN, la réorganisation de structures secondaires ou de remodeler des complexes ARN-protéines. L'hélicase DEAH/RHA Prp43 présente la particularité d'être bifonctionnelle. Prp43 est impliquée dans l'épissage des Pré-ARNm, où elle assure le recyclage du spliceosome et du lasso, mais aussi dans la biogenès

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2

Muraru, Mariela I. "Functional analysis of Prp45p, a pre-mRNA splicing factor in Saccharomyces cerevisiae." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/15461.

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In this study we aimed to understand the role Prp45p executes within the spliceosome and the splicing mechanism. Part of this work was a detailed investigation into the relationships between the structure and the function of this protein by employing a screen for temperature-sensitive mutants. Prp45p is known to associate with the spliceosome throughout the splicing reactions but at what stage the protein is involved in spliceosome assembly i.e. pre-spliceosome, inactive or active spliceosome remained to be determined. Using a <i>PRP45</i> conditionally regulated strain, it was found upon depl

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3

Ester, Claudia. "Protein-Protein-Interaktionen der U1snRNP-Komponente Prp40 und deren FF-Domänen in Saccharomyces cerevisiae." Karlsruhe Forschungszentrum Karlsruhe, 2007. http://d-nb.info/985063238/34.

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4

Halladjian, Maral. "Etude de la fonction de l'hélicase Prp43 dans la synthèse des ribosomes et des connexions entre synthèse et maturation du pré-ARN ribosomique chez la levure." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30156.

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Dans les cellules eucaryotes, la biogenèse des ribosomes débute par la transcription des unités répétées d'ADN ribosomique (ADNr) par l'ARN polymérase I (Pol I). Ce processus génère un transcrit primaire (pré-ARNr), qui contient les séquences correspondant aux ARNr matures 18S, 5.8S et 25S. Le quatrième ARNr (5S) est transcrit indépendamment par Pol III. Le pré-ARNr s'associe de manière co-transcriptionnelle avec des protéines ribosomiques et de nombreux facteurs de maturation pour former une grande particule pré-ribosomique précoce appelée " particule 90S ". Cette particule précoce subit des

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5

Nordzieke, Steffen Verfasser], Ulrich [Akademischer Betreuer] Kück, and Dominik [Akademischer Betreuer] [Begerow. "Molecular genetic studies of PRO45 in \(\textit Sordaria macrospora}\) / Steffen Nordzieke. Gutachter: Ulrich Kück ; Dominik Begerow." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1095884573/34.

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6

Ester, Claudia [Verfasser]. "Protein-Protein-Interaktionen der U1snRNP-Komponente Prp40 und deren FF-Domänen in Saccharomyces cerevisiae / Claudia Ester." Karlsruhe : Forschungszentrum Karlsruhe, 2007. http://d-nb.info/985063238/34.

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7

Albers, Michael. "Identification and characterisation of Prp45p and Prp46p : two novel pre-mRNA splicing factors in Saccharomyces cerevisiae." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/10998.

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We set out to investigate protein-protein interactions within the spliceosome of the budding yeast <I>Saccharomyces cerevisiae </I>by performing exhaustive two-hybrid screens using well characterised splicing proteins as baits. This approach should allow the identification of i) novel splicing proteins, ii) novel interactions between known splicing factors and iii) links between splicing and other cellular pathways, especially processes of mRNA metabolism. Prp22p is an RNA-helicase with at least two distinct functions in the splicing pathway. It is required for the second transesterification r

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8

Nordzieke, Steffen Verfasser], Ulrich [Akademischer Betreuer] [Kück, and Dominik [Akademischer Betreuer] Begerow. "Molecular genetic studies of PRO45 in \(\textit Sordaria macrospora}\) / Steffen Nordzieke. Gutachter: Ulrich Kück ; Dominik Begerow." Bochum : Ruhr-Universität Bochum, 2016. http://nbn-resolving.de/urn:nbn:de:hbz:294-47289.

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9

Saguez, Cyril. "Dynamique d'assemblage de la snRNP U4/U6 : étude des facteurs mis en jeu." Paris 7, 2002. http://www.theses.fr/2002PA077170.

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10

Christian, Henning [Verfasser], Ralf [Akademischer Betreuer] Ficner, and Reinhard [Akademischer Betreuer] Lührmann. "Insights into the activation of the spliceosomal helicase Prp43 / Henning Christian. Gutachter: Ralf Ficner ; Reinhard Lührmann. Betreuer: Ralf Ficner." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044871571/34.

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11

Banerjee, Daipayan. "CHARACTERIZATION OF G-PATCH MOTIF CONTRIBUTION TO PRP43 FUNCTION IN THE PRE-MESSENGER RNA SPLICING AND RIBOSOMAL RNA BIOGENESIS PATHWAYS." UKnowledge, 2013. http://uknowledge.uky.edu/biology_etds/10.

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The DExD/H-box protein Prp43 is essential for two biological processes: nucleoplasmic pre-mRNA splicing and nucleolar rRNA maturation. The biological basis for the temporal and spatial regulation of Prp43 remains elusive. The Spp382/Ntr1, Sqs1/Pfa1 and Pxr1/Gno1 G-patch proteins bind to and activate the Prp43 DExD/H box-helicase in pre-mRNA splicing (Spp382) and rRNA processing (Sqs1, Pxr1). These Prp43-interacting proteins each contain the G-patch domain, a conserved sequence of ~48 amino acids that includes 6 highly conserved glycine (G) residues. Five annotated G-patch proteins in baker’s y

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12

Wiesner, Silke. "NMR studies of the yeast splicing factor Prp40 structures and ligand recognition of a WW domain pair and an FF domain /." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/66/index.html.

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13

Eckert, Daniela [Verfasser], and Norbert F. [Akademischer Betreuer] Käufer. "Die Serin/Threonin Kinase Prp4 aus Schizosaccharomyces pombe verbessert die Erkennung von Introns mit schwachen Spleißstellen / Daniela Eckert ; Betreuer: Norbert F. Käufer." Braunschweig : Technische Universität Braunschweig, 2015. http://d-nb.info/1175819298/34.

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14

AYADI, LILIA. "La proteine prp4 : role dans l'assemblage du complexe d'epissage chez la levure s. cerevisiae, modelisation et definition du domaine d'interaction avec prp3." Paris 11, 1997. http://www.theses.fr/1997PA112322.

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L'epissage des arn premessagers chez la levure se fait au sein d'un large complexe ribonucleoproteique dont l'assemblage necessite l'intervention de nombreuses proteines. L'une d'entre elles, prp4, est retrouvee au niveau des snrnps u4/u6 et u4/u6-u5, mais aussi dans le spliceosome avant la premiere etape de la catalyse. Elle quitte le spliceosome juste avant la premiere etape d'epissage, au moment ou le snrna u4 se detache du complexe. Une analyse biochimique fine de mutants prp4 nous a permis de montrer que prp4 etait impliquee dans l'etape de relargage de u4. En effet, nous avons pu observe

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15

Serrat, Farran Xènia 1993. "Unraveling the functional roles of sftb-1/SF3B1 and prpf-4/PRPF4B in Caenorhabditis elegans splicing and human disease." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668152.

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Caenorhabditis elegans provides a powerful experimental system for understanding fundamental questions in biomedical research, including the consequences of pre-mRNA splicing alterations. Here, we have applied CRISPR and RNA-sequencing technologies to investigate the functions of two evolutionary conserved splicing factors that have been linked to disease in different ways. We have established that cancer-related mutations in sftb-1 cause splicing alterations in C. elegans. The use of distinct alleles has uncovered novel synthetic lethal interactions between sftb-1 mutations and further pertu

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16

Andrée-Busch, Nicole Verfasser], Norbert F. [Akademischer Betreuer] Käufer, and André [Akademischer Betreuer] [Fleißner. "Die Serin/Threonin Kinase Prp4 und die SR Proteine sind Teil eines Mechanismus, der in Schizosaccharomyces pombe das Herausspleißen von Introns mit schwachen Spleißstellen sicherstellt und koordiniert / Nicole Andrée-Busch ; Norbert F. Käufer, André Fleißner." Braunschweig : Technische Universität Braunschweig, 2019. http://d-nb.info/1189810921/34.

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17

Brooks, Scott A. "To move, to please, and to teach : the new poetry and the new music, and the works of Edmund Spenser and John Milton, 1579-1674." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/5034.

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By examining Renaissance criticism both literary and musical, framed in the context of the contemporaneous obsession with the works of Plato, Aristotle, and Horace, among others, this thesis identifies the parallels in poetic and musical practices of the time that coalesce to form a unified idea about the poet-as-singer, and his role in society. Edmund Spenser and John Milton, who both, in various ways, lived in periods of upheaval, identified themselves as the poet-singer, and comprehending their poetry in the context of this idea is essential to a fuller appreciation thereof. The first chapt

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18

Kratochvílová, Eliška. "Fyzické interakce sestřihového faktoru Prp45." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-268028.

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It is well known that chromatin posttranslational state, transcription and splicing influence each other. Nevertheless, the details of this coupling are not fully understood. In S. cerevisiae, it is possible to induce conditions, in which splicing is uncoupled from transcription. Such situation occurred in cells expressing a mutated splicing factor Prp45, whose human homolog has been proved to participate in transcription regulation and also in splicing reactions. Based on previously indicated interactions in high throughput two-hybrid screens, we have been looking for physical links between P

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19

Valentová, Anna. "Genetické interakce mutace PRP45 v S. cerevisiae." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-272265.

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20

Abrhámová, Kateřina. "Role proteinu Prp45 v expresi a zrání mRNA." Doctoral thesis, 2010. http://www.nusl.cz/ntk/nusl-295426.

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Prp45p of Saccharomyces cerevisiae and Snw1p of Schizosaccharomyces pombe are essential proteins, which share extensive homology with the mammalian transcription regulator and splicing factor SNW/SKIP. We have analyzed the essential function of these proteins in both yeasts and found a mutation (prp45(1-169)) that exhibited temperature sensitivity. The mutant strain harboring the corresponding chromosomal deletion shows temperature sensitive phenotype and hypersensitivity to cycloheximide, hydroxyurea, calcofluor white, and to microtubule inhibitors. At 30řC, the cells are often elongated, def

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21

Šimonová, Tereza. "Fenotyp Saccharomyces cerevisiae s delecí v genu Prp45." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-375011.

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22

Konířová, Jana. "Sestřih intronu TUB3i v buňkách mutantních v genu PRP45." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-295878.

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Protein Prp45, an essential factor of the yeast Saccharomyces cerevisiae, is implicated in pre-mRNA splicing. A truncated version of the PRP45 gene, prp45(1-169), which exhibits a temperature sensitivity, was previously prepared in our laboratory. The aim of this work is to contribute to better understanding of prp45(1-169) mutant phenotype. We tested the prp45(1-169) strain for its response to microtubule inhibitor benomyl and then we found that TUB3 overexpression from plasmid rescues discovered prp45(1-169) mutant cells hypersensitivity to benomyl. In addition, we studied the influence of T

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23

Senohrábková, Lenka. "Interakce proteinů Prp22 a Prp45 ve spliceosomu pučící kvasinky." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-296547.

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Protein Prp22 is a DEAH box RNA helicase, which plays two distinct roles in pre-mRNA splicing: it participates in second transesterification step (ATP independent function) and it releases mature mRNA from the spliceosome (ATP dependent function). Prp45p, yeast ortholog of the human transcription co-regulator SNW/SKIP, is an essential splicing factor, it is included in spliceosome throughout the splicing reaction. Mutant prp45(1-169) genetically interacts with some alleles of NTC complex and second step splicing factors, one of them is also gene PRP22. Here we present, that mutants prp22(-158T

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24

Hálová, Martina. "Role sestřihových faktorů v regulaci genové exprese - vztah sestřihu a transkripce v Saccharomyces cerevisiae." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-405580.

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Transcription and pre-mRNA processing, e.g., splicing, occur at the same place and time in the context of chromatin. A growing amount of evidence supports the hypothesis that these processes are interconnected. Prp45/SKIP is one of the factors which are believed to mediate the interconnection. The human ortholog, SKIP, is known for affecting mRNA formation on the levels of transcription initiation and elongation. Moreover, it interacts with chromatin modifiers and it is a splicing factor, too. The function of the Saccharomyces cerevisiae ortholog, Prp45, has been so far connected only to pre-m

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25

Cihlářová, Zuzana. "Prp45 v regulaci exprese paralogních genů TUB1 a TUB3 v S. cerevisiae." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355670.

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Prp45 is an essential splicing factor of budding yeast Saccharomyces cerevisiae. The human ortholog of Prp45 - protein SNW1/SKIP - is involved in splicing and probably influences transcription and histone modification. The genetic interacion of Prp45 with splicing factors is well described. We have additionally demonstrated that Prp45 genetically interacts also with factors involved in transcription regulation and histone modification enzymes. Our preliminary data therefore suggest that Prp45 might be a factor that connects processes of splicing, transcription, and chromatine modification and

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26

Hálová, Martina. "Efektory chromatinových modifikací a jejich vztah k regulaci transkripce na modelu Saccharomyces cerevisiae." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-313232.

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Relations among transcription, pre-mRNA processing and chromatin modifications are only partially understood. The human protein SNW1/SKIP belongs to factors which couple these processes. The protein plays role in pre-mRNA splicing and transcription on the level of both initiation and elongation. According to the hypothesis of K. Jones laboratory, it physically and functionally interacts with positive transcription elongation factor b during transcription elongation and influences methylation of histone H3 on lysine 4, a modification characteristic for active transcription (Bres et al., Genes D

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27

Kovaľová, Libuša. "Vztah mezi sestřihem a posttranslačními modifikacemi chromatinu v Saccharomyces cerevisiae." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388506.

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Protein Prp45, the yeast ortholog of the human transcription coregulator SNW1/SKIP, has been previously associated only with the regulation of pre-mRNA splicing. However, our laboratory found that protein Prp45 genetically interacts not only with the proteins involved in pre-mRNA splicing, but also with factors important for transcription elongation and with chromatin modifying enzymes. Our data and the information about the human ortholog SNW1/SKIP suggest that Prp45 could serve as a regulator coupling splicing, transcription and chromatin state in S. cerevisiae. The main aim of this diploma

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28

Cit, Zdeněk. "Sestřih atypických intronů v S. cerevisiae." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-305800.

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Pre-mRNA splicing is a vital process of gene expression important for all eukaryotic organisms. For the proper function of this very complex and dynamic event the presence of few specialized RNA and many proteins that hold a variety of tasks is necessary, not only inside the splicing complex itself, but also beyond this complex. The Prp45 is one of the proteins involved in pre-mRNA splicing in yeast Saccharomyces cerevisiae. Its human homologue, SNW1/SKIP, is involved in splicing but also in other crucial cell processes. The Prp45 protein was reliably reported only to participate in the second

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29

Chen, Kai, and 陳楷. "Structural and functional study of Prp43." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/48334223419148892511.

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碩士<br>國立陽明大學<br>生命科學系暨基因體科學研究所<br>100<br>RNA helicase Prp43 forms a functional NTR complex with Ntr1 and Ntr2, and catalyzes disassembly of the spliceosome to recycle splicing factors. Yeast two-hybrid assays have revealed that an N-terminal segment of Prp43, Prp43-N306, which only contains Prp43-specific N-terminal domain and the RecA1 domain, can interact with Ntr1. The G-patch domain of Ntr1 has been shown to interact with Prp43 to stimulate Prp43’s helicase activity. However, a recent study showed that the C-terminal domain of Prp43 is involved in the binding of the G-patch domain of Pfa1,

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30

Liang, Wen-Wei, and 梁雯薇. "Functional Role of Prp5 in Prespliceosome Formation." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/66777680640670438718.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>99<br>The DExD/H-box Prp5 protein has been demonstrated to be required for the prespliceosome formation via its ATP-dependent and ATP-independent activities. Functional roles of Prp5 in later steps of the spliceosome pathway and in splicing fidelity control have also been implicated. In this thesis, I examined whether the functional role of Prp5 in splicing is restricted to prespliceosome formation. For NTC-depleted or Spp2-depleted extracts, Prp5 depletion did not affect complementation of purified NTC or recombinant Spp2, demonstrating that Prp5 is not required

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31

Christian, Henning. "Insights into the activation of the spliceosomal helicase Prp43." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0001-BC73-A.

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32

Schwelnus, Wiebke [Verfasser]. "Untersuchungen zur Interaktion von Prp4p-Kinase und dem Spleißfaktor Prp1p / von Wiebke Schwelnus." 2005. http://d-nb.info/974473707/34.

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33

Bottner, Claudia [Verfasser]. "Die Phosphorylierung von Prp1p durch Prp4p-Kinase ist notwendig zur Aktivierung von prä-katalytischen Spleißosomen / von Claudia Bottner." 2006. http://d-nb.info/979088240/34.

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34

Hamann, Florian. "Biophysical and Crystallographic Characterization of Spliceosomal DExD/H-box ATPases." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-1386-E.

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35

Wiesner, Silke [Verfasser]. "NMR studies of the yeast splicing factor Prp40 : structures and ligand recognition of a WW domain pair and an FF domain / vorgelegt von Silke Wiesner." 2003. http://d-nb.info/967124824/34.

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36

Richert, Kathrin [Verfasser]. "Untersuchungen zur Aufklärung des Prä-mRNA-Spleißvorgangs in der Spalthefe Schizosaccharomyces pombe : genetische und biochemische Charakterisierung der Interaktionen des prp4-Gens / von Kathrin Richert." 2003. http://d-nb.info/966590406/34.

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