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Journal articles on the topic 'Pseudonoja textilis'

Author: Grafiati

Published: 18 May 2024

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1

Tibballs, J., and S. Sutherland. "The Efficacy of Antivenom in Prevention of Cardiovascular Depression and Coagulopathy Induced by Brown Snake (Pseudonaja) Species Venom." Anaesthesia and Intensive Care 19, no. 4 (1991): 530–34. http://dx.doi.org/10.1177/0310057x9101900407.

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The efficacy of antivenom in prevention of cardiovascular depression and coagulopathy induced by Brown Snake species (Pseudonaja textilis, Pseudonaja affinis) was investigated in anaesthetised mechanically ventilated dogs. Venom and antivenom in variable amounts were incubated together at 37°C for 30 minutes prior to intravenous injection. The dose of antivenom required to prevent severe cardiovascular depression and coagulopathy induced by Pseudonaja textilis venom was 25 times the current recommended dose for clinical use. A tenfold dose of antivenom was required to neutralise similar effect

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2

Tibballs, J., S. K. Sutherland, R. A. Rivera, and P. P. Masci. "The Cardiovascular and Haematological Effects of Purified Prothrombin Activator from the Common Brown Snake (Pseudonaja textilis) and their Antagonism with Heparin." Anaesthesia and Intensive Care 20, no. 1 (1992): 28–32. http://dx.doi.org/10.1177/0310057x9202000105.

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The cardiovascular and haematological effects of purified prothrombin activator derived from the venom of the Australian Common Brown Snake (Pseudonaja textilis) were studied in anaesthetised, mechanically ventilated dogs. Severe depression of systemic blood pressure and cardiac output and a rise in central venous pressure were observed. Thrombocytopenia, prolongation of both prothrombin time and activated partial thromboplastin time and a reduction in serum fibrinogen were also observed. All of these observed effects were prevented by the prior administration of heparin — a naturally occurrin

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3

Armugam, Arunmozhiarasi, NanLing Gong, XiaoJie Li, et al. "Group IB phospholipase A2 from Pseudonaja textilis." Archives of Biochemistry and Biophysics 421, no. 1 (2004): 10–20. http://dx.doi.org/10.1016/j.abb.2003.09.045.

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4

Gong, Nanling, Arunmozhiarasi Armugam, and Kandiah Jeyaseelan. "Postsynaptic short-chain neurotoxins from Pseudonaja textilis." European Journal of Biochemistry 265, no. 3 (2001): 982–89. http://dx.doi.org/10.1046/j.1432-1327.1999.00800.x.

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5

Tibballs, J., and S. K. Sutherland. "The Efficacy of Heparin in the Treatment of Common Brown Snake (Pseudonaja textilis) Envenomation." Anaesthesia and Intensive Care 20, no. 1 (1992): 33–37. http://dx.doi.org/10.1177/0310057x9202000106.

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The efficacy of heparin therapy after subcutaneous injection of Common Brown Snake (Pseudonaja textilis) venom was studied in anaesthetised, mechanically ventilated dogs. Intravenous heparin (100 U/kg), administered fifteen minutes after envenomation, neither prevented nor hastened the recovery from cardiovascular depression and coagulopathy observed after venom administration. Heparin therapy is not recommended for the treatment of established human envenomation.

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6

Watson, Gregory S., David W. Green, and Jolanta A. Watson. "Observations supporting parental care by a viviparous reptile: aggressive behaviour against predators demonstrated by Cunningham’s skinks." Australian Journal of Zoology 67, no. 3 (2019): 180. http://dx.doi.org/10.1071/zo20024.

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Most reptiles exhibit no parental care and aggressive behaviour towards heterospecific predators has rarely been recorded in the natural environment. Several species of the subfamily Egerniinae are amongst the most highly social of all squamate reptiles, exhibiting stable social aggregations and high levels of long-term social and genetic monogamy. We have examined Cunningham’s skinks, Egernia cunninghami, over a three-year period during late January and early February (total 32 days) in the alpine region of New South Wales using video and thermal imaging. Four birthing sessions were witnessed

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7

Whitaker, P. B., K. Ellis, and R. Shine. "The defensive strike of the Eastern Brownsnake, Pseudonaja textilis (Elapidae)." Functional Ecology 14, no. 1 (2000): 25–31. http://dx.doi.org/10.1046/j.1365-2435.2000.00385.x.

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8

Willmott, N., P. Gaffney, P. Masci, and A. Whitaker. "A novel serine protease inhibitor from the Australian brown snake, Pseudonaja textilis textilis: Inhibition kinetics." Fibrinolysis 9, no. 1 (1995): 1–8. http://dx.doi.org/10.1016/s0268-9499(08)80040-9.

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9

GONG, NanLing, Arunmozhiarasi ARMUGAM, Peter MIRTSCHIN, and Kandiah JEYASEELAN. "Cloning and characterization of the pseudonajatoxin b precursor." Biochemical Journal 358, no. 3 (2001): 647–56. http://dx.doi.org/10.1042/bj3580647.

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An Australian common brown snake, Pseudonaja textilis, is known to contain highly lethal neurotoxins. Among them, a long-chain α-neurotoxin, pseudonajatoxin b, has been identified. In this report, while presenting evidence for the presence of at least four such long-chain α-neurotoxins in the venom of P. textilis, we describe the characteristics of both the mRNA and the gene responsible for the synthesis of these neurotoxins. A precursor toxin synthesized from the gene has been identified as being capable of producing the isoforms possibly by post-translational modifications at its C-terminal

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10

Tibballs, J., S. Sutherland, and S. Kerr. "Studies on Australian Snake Venoms. Part 1: The Haemodynamic Effects of Brown Snake (Pseudonaja) Species in the Dog." Anaesthesia and Intensive Care 17, no. 4 (1989): 466–69. http://dx.doi.org/10.1177/0310057x8901700412.

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The haemodynanic effects of Brown Snake (Pseudonaja) species (textilis, nuchalis, affinis) were investigated in anaesthetised, mechanically ventilated dogs. Blood pressure decreased to minimal levels five minutes after intravenous envenomation. Hypotension was accompanied by significant decrements in cardiac output and stroke volume and a rise in peripheral vascular resistance. Heart rate increased transiently during 0.5-2.0 minutes after envenomation but had declined below resting levels five minutes after envenomation. No statistically significant change was recorded in central venous pressu

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11

Birrell, Geoff W., Stephen Earl, Paul P. Masci, et al. "Molecular Diversity in Venom from the Australian Brown Snake,Pseudonaja textilis." Molecular & Cellular Proteomics 5, no. 2 (2005): 379–89. http://dx.doi.org/10.1074/mcp.m500270-mcp200.

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12

Henderson, Alan, Lee N. Baldwin, and Christopher May. "Fatal Brown Snake (Pseudonaja textilis) Envenomation Despite the use of Antivenom." Medical Journal of Australia 158, no. 10 (1993): 709–10. http://dx.doi.org/10.5694/j.1326-5377.1993.tb121923.x.

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13

Masci, P. P., A. N. Whitaker, L. G. Sparrow, et al. "Textilinins from Pseudonaja textilis textilis. Characterization of two plasmin inhibitors that reduce bleeding in an animal model." Blood Coagulation and Fibrinolysis 11, no. 4 (2000): 385–93. http://dx.doi.org/10.1097/00001721-200006000-00011.

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14

WILLIAMS, DAVID J., MARK O'SHEA, ROLAND L. DAGUERRE, et al. "Origin of the eastern brownsnake, Pseudonaja textilis (Dumeril, Bibron and Dumeril) (Serpentes: Elapidae: Hydrophiinae) in New Guinea: evidence of multiple dispersals from Australia, and comments on the status of Pseudonaja textilis pughi Hoser 2003." Zootaxa 1703, no. 1 (2008): 47. http://dx.doi.org/10.11646/zootaxa.1703.1.3.

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Pseudonaja textilis is a widespread and common snake in eastern parts of Australia, but its distribution in New Guinea is poorly understood, and the origin of the New Guinea populations and its timing have been the subject of much speculation. Phylogenetic analysis of mitochondrial DNA sequences from three New Guinea populations of P. textilis indicates that New Guinea was colonised from two independent eastern and western migration routes most likely in the Pleistocene. One dispersal event from northern Queensland led to the populations in eastern New Guinea (Milne Bay, Oro and Central Provin

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15

Whitaker, P. B., and R. Shine. "Responses of free-ranging brownsnakes (Pseudonaja textilis : Elapidae) to encounters with humans." Wildlife Research 26, no. 5 (1999): 689. http://dx.doi.org/10.1071/wr98042.

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Eastern brownsnakes (Pseudonaja textilis) are large (to 2 m), slender, dangerously venomous elapid snakes that cause significant human mortality. We recorded the responses of free-ranging brownsnakes to 455 close encounters with a human observer, using 40 snakes implanted with miniature radio-transmitters, plus encounters with non-telemetered animals. Our study area (near Leeton in south-eastern Australia) is typical of many of the agricultural landscapes occupied by P. textilis. Contrary to public opinion, the snakes were rarely aggressive. About half of the encounters resulted in the snake r

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16

Whitaker, P. B., and R. Shine. "When, where and why do people encounter Australian brownsnakes (Pseudonaja textilis : Elapidae)?" Wildlife Research 26, no. 5 (1999): 675. http://dx.doi.org/10.1071/wr98043.

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Encounters between humans and dangerously venomous snakes put both participants at serious risk, so the determinants of such encounters warrant attention. Pseudonaja textilis is a large fast-moving elapid snake responsible for most snakebite fatalities in Australia. As part of a broad ecological study of this species in agricultural land near Leeton, New South Wales, we set out to identify factors influencing the probability that a human walking in farmland would come into close proximity to a brownsnake. Over a three-year period, we walked regular transects to quantify the number and rate of

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17

Lechtenberg, Bernhard C., Thomas A. Murray-Rust, Daniel J. D. Johnson, et al. "Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis." Blood 122, no. 16 (2013): 2777–83. http://dx.doi.org/10.1182/blood-2013-06-511733.

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18

Masci, P. P., P. J. Mirtschin, T. N. Nias, R. K. Turnbull, T. R. Kuchel, and A. N. Whitaker. "Brown Snakes (Pseudonaja Genus): Venom Yields, Prothrombin Activator Neutralization and Implications Affecting Antivenom Usage." Anaesthesia and Intensive Care 26, no. 3 (1998): 276–81. http://dx.doi.org/10.1177/0310057x9802600308.

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The recent high prevalence of fatal bites by Brown snakes (Pseudonaja genus) has led to this study of venom yields from 66 brown snake milkings over 15 months. The amount of venom obtained from all species was higher than reported previously. Electrophoretic and Western blotting analyses of their venoms showed significantly lower avidity of Brown snake antivenom (BS-AV) for the prothrombin activator (PA) component (190 kD) than for other venom components, including the neurotoxins. The LD50 of P. inframacula has been determined for the first time. SDS-PAGE (sodium dodecyl sulphate-polyacrylami

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19

Chaisakul, Janeyuth, Geoffrey K. Isbister, Sanjaya Kuruppu, Nicki Konstantakopoulos, and Wayne C. Hodgson. "An examination of cardiovascular collapse induced by eastern brown snake (Pseudonaja textilis) venom." Toxicology Letters 221, no. 3 (2013): 205–11. http://dx.doi.org/10.1016/j.toxlet.2013.06.235.

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20

Whitaker, P. B., and R. Shine. "THERMAL BIOLOGY AND ACTIVITY PATTERNS OF THE EASTERN BROWNSNAKE (PSEUDONAJA TEXTILIS): A RADIOTELEMETRIC STUDY." Herpetologica 58, no. 4 (2002): 436–52. http://dx.doi.org/10.1655/0018-0831(2002)058[0436:tbaapo]2.0.co;2.

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21

WHITE, J., and V. WILLIAMS. "Severe envenomation with convulsion following multiple bites by a common brown snake, Pseudonaja textilis." Journal of Paediatrics and Child Health 25, no. 2 (1989): 109–11. http://dx.doi.org/10.1111/j.1440-1754.1989.tb01430.x.

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22

Chaisakul, Janeyuth, Geoffrey K. Isbister, Margaret A. O'Leary, et al. "Prothrombin activator-like toxin appears to mediate cardiovascular collapse following envenoming by Pseudonaja textilis." Toxicon 102 (August 2015): 48–54. http://dx.doi.org/10.1016/j.toxicon.2015.05.001.

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23

Rehorek, Susan J., Mimi Halpern, Bruce T. Firth, and Mark N. Hutchinson. "The Harderian gland of two species of snakes: Pseudonaja textilis (Elapidae) and Thamnophis sirtalis (Colubridae)." Canadian Journal of Zoology 81, no. 3 (2003): 357–63. http://dx.doi.org/10.1139/z03-014.

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The reptilian Harderian gland is a poorly understood cephalic structure. Despite the recent assertion that in snakes it may function as part of the vomeronasal system, the Harderian gland has been described in few snake species. In this study we examined the gross anatomy, histology, and ultrastructure of the Harderian gland of two different advanced snake species (Colubroidea): Pseudonaja textilis (Elapidae) and Thamnophis sirtalis (Colubridae). In both species the Harderian gland is a large serous gland whose secretions pass directly into the vomeronasal organ via the nasolacrimal duct. Cont

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24

Mirtschin, P. J., R. Shine, T. J. Nias, N. L. Dunstan, B. J. Hough, and M. Mirtschin. "Influences on venom yield in Australian tigersnakes (Notechis scutatus) and brownsnakes (Pseudonaja textilis: Elapidae, Serpentes)." Toxicon 40, no. 11 (2002): 1581–92. http://dx.doi.org/10.1016/s0041-0101(02)00175-7.

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25

Stocker, Kurt, Helena Hauer, Christian Müller, and Douglas A. Triplett. "Isolation and characterization of TextarinR, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom." Toxicon 32, no. 10 (1994): 1227–36. http://dx.doi.org/10.1016/0041-0101(94)90352-2.

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26

Williams, V., and J. White. "Characteristics of the procoagulant front the venom of the Australian common brown snake (Pseudonaja textilis)." Toxicon 33, no. 3 (1995): 257. http://dx.doi.org/10.1016/0041-0101(95)99233-s.

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27

Schreuder, Mark, Geraldine Poenou, Viola J. F. Strijbis, Ka Lei Cheung, Pieter H. Reitsma, and Mettine H. A. Bos. "Evolutionary Adaptations in Pseudonaja Textilis Venom Factor X Induce Zymogen Activity and Resistance to the Intrinsic Tenase Complex." Thrombosis and Haemostasis 120, no. 11 (2020): 1512–23. http://dx.doi.org/10.1055/s-0040-1715441.

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AbstractThe venom of the Australian snake Pseudonaja textilis comprises powerful prothrombin activators consisting of factor X (v-ptFX)- and factor V-like proteins. While all vertebrate liver-expressed factor X (FX) homologs, including that of P. textilis, comprise an activation peptide of approximately 45 to 65 residues, the activation peptide of v-ptFX is significantly shortened to 27 residues. In this study, we demonstrate that exchanging the human FX activation peptide for the snake venom ortholog impedes proteolytic cleavage by the intrinsic factor VIIIa–factor IXa tenase complex. Further

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28

Whitaker, Patrick Brian, and Richard Shine. "A RADIOTELEMETRIC STUDY OF MOVEMENTS AND SHELTER-SITE SELECTION BY FREE-RANGING BROWNSNAKES (PSEUDONAJA TEXTILIS, ELAPIDAE)." Herpetological Monographs 17, no. 1 (2003): 130. http://dx.doi.org/10.1655/0733-1347(2003)017[0130:arsoma]2.0.co;2.

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29

Minh Le, Thi Nguyet, Md Abu Reza, Sanjay Swarup, and R. Manjunatha Kini. "Gene duplication of coagulation factor V and origin of venom prothrombin activator in Pseudonaja textilis snake." Thrombosis and Haemostasis 93, no. 03 (2005): 420–29. http://dx.doi.org/10.1160/th04-11-0707.

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SummaryThe origin and evolution of venom toxins is a mystery that has evoked much interest. We have recently shown that pseutarin C, a prothrombin activator from Pseudonaja textilis venom, is structurally and functionally similar to mammalian coagulation factor Xa – factor Va complex. Its catalytic subunit is homologous to factor Xa while the nonenzymatic subunit is homologous to factor Va. P.textilis therefore has two parallel prothrombin activator systems: one expressed in its venom gland as a toxin and the other expressed in its liver and released into its plasma as a haemostatic factor. He

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30

Filippovich, Igor, Natasha Sorokina, Liam St Pierre, et al. "Cloning and functional expression of venom prothrombin activator protease from Pseudonaja textilis with whole blood procoagulant activity." British Journal of Haematology 131, no. 2 (2005): 237–46. http://dx.doi.org/10.1111/j.1365-2141.2005.05744.x.

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31

Viala, Vincent Louis, Diana Hildebrand, Maria Trusch, et al. "Venomics of the Australian eastern brown snake ( Pseudonaja textilis ): Detection of new venom proteins and splicing variants." Toxicon 107 (December 2015): 252–65. http://dx.doi.org/10.1016/j.toxicon.2015.06.005.

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32

Aird, Steven D., C. Russell Middaugh, and Ivan I. Kaiser. "Spectroscopic characterization of textilotoxin, a presynaptic neurotoxin from the venom of the australian eastern brown snake (Pseudonaja t. textilis)." Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 997, no. 3 (1989): 219–23. http://dx.doi.org/10.1016/0167-4838(89)90190-8.

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33

Skejić, Jure, and Wayne C. Hodgson. "Population Divergence in Venom Bioactivities of Elapid Snake Pseudonaja textilis: Role of Procoagulant Proteins in Rapid Rodent Prey Incapacitation." PLoS ONE 8, no. 5 (2013): e63988. http://dx.doi.org/10.1371/journal.pone.0063988.

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34

Bos, Mettine H. A., Michael Boltz, Liam St. Pierre, et al. "Venom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations." Blood 114, no. 3 (2009): 686–92. http://dx.doi.org/10.1182/blood-2009-02-202663.

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Abstract Venomous snakes produce an array of toxic compounds, including procoagulants to defend themselves and incapacitate prey. The Australian snake Pseudonaja textilis has a venom-derived prothrombin activator homologous to coagulation factors V (FV) and Xa (FXa). Here we show that the FV component (pt-FV) has unique biologic properties that subvert the normal regulatory restraints intended to restrict an unregulated procoagulant response. Unlike human FV, recombinant pt-FV is constitutively active and does not require proteolytic processing to function. Sequence comparisons show that it ha

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35

Gilbert, Gary E., Valerie A. Novakovic, Randal J. Kaufman, Hongzhi Miao, and Steven W. Pipe. "Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity." Blood 120, no. 9 (2012): 1923–32. http://dx.doi.org/10.1182/blood-2012-01-408245.

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Abstract Factor VIII and factor V share structural homology and bind to phospholipid membranes via tandem, lectin-like C domains. Their respective C2 domains bind via 2 pairs of hydrophobic amino acids and an amphipathic cluster. In contrast, the factor V-like, homologous subunit (Pt-FV) of a prothrombin activator from Pseudonaja textilis venom is reported to function without membrane binding. We hypothesized that the distinct membrane-interactive amino acids of these proteins contribute to the differing membrane-dependent properties. We prepared mutants in which the C2 domain hydrophobic amin

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36

Rao, Veena, Sanjay Swarup, and Manjunatha Kini. "The catalytic subunit of pseutarin C, a group C prothrombin activator from the venom of Pseudonaja textilis, is structurally similar to mammalian blood coagulation factor Xa." Thrombosis and Haemostasis 92, no. 09 (2004): 509–21. http://dx.doi.org/10.1160/th04-03-0144.

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SummaryPseutarin C, a group C prothrombin activator from Pseudonaja textilis venom, is a large protein complex consisting of catalytic and nonenzymatic subunits, which are functionally similar to the mammalian FXa-FVa complex. Here, we present the complete cDNA sequence of the catalytic subunit of pseutarin C. The cDNA of the catalytic subunit encodes a protein of 449 amino acids, which includes a 22-residue signal peptide, 18-residue propeptide and a mature protein of 409 amino acids. The deduced amino acid sequence shows 74-83% identity to group D prothrombin activators from snake venom and

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37

REZA, M. A., T. N. MINH LE, S. SWARUP, and R. MANJUNATHA KINI. "Molecular evolution caught in action: gene duplication and evolution of molecular isoforms of prothrombin activators in Pseudonaja textilis (brown snake)." Journal of Thrombosis and Haemostasis 4, no. 6 (2006): 1346–53. http://dx.doi.org/10.1111/j.1538-7836.2006.01969.x.

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38

Williams, V., and J. White. "Variation in the composition of the venom from a single specimen of Pseudonaja textilis (common brown snake) over one year." Toxicon 30, no. 2 (1992): 202–6. http://dx.doi.org/10.1016/0041-0101(92)90473-i.

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39

Rao, Veena, and R. Kini. "Pseutarin C, a Prothrombin Activator from Pseudonaja textilis Venom: Its Structural and Functional Similarity to Mammalian Coagulation Factor Xa-Va Complex." Thrombosis and Haemostasis 88, no. 10 (2002): 611–19. http://dx.doi.org/10.1055/s-0037-1613264.

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SummarySeveral snake venoms contain procoagulant proteins that can activate prothrombin. We have purified pseutarin C, a prothrombin activator from the venom of the Australian brown snake (Pseudonaja textilis). It converts prothrombin to thrombin by cleaving both the peptide bonds Arg274 – Thr275 and Arg323 – Ile324, similar to mammalian factor Xa. It is a protein complex (∼250 Kd) consisting of an enzymatic and a nonenzymatic subunit. These subunits were separated by reverse phase HPLC and their interactions with bovine factor Xa and factor Va were studied. The enzymatic subunit of pseutarin

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40

TYLER, Margaret I., Merlin E. H. HOWDEN, Ian SPENCE, and Donald BARNETT. "Pseudonajatoxin b: unusual amino acid sequence of a lethal neurotoxin from the venom of the Australian common brown snake, Pseudonaja textilis." European Journal of Biochemistry 166, no. 1 (1987): 139–43. http://dx.doi.org/10.1111/j.1432-1033.1987.tb13493.x.

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41

Leong, Oriana S., Andrew M. Padula, and Ellie Leister. "Severe acute pulmonary haemorrhage and haemoptysis in ten dogs following eastern brown snake (Pseudonaja textilis) envenomation: Clinical signs, treatment and outcomes." Toxicon 150 (August 2018): 188–94. http://dx.doi.org/10.1016/j.toxicon.2018.05.020.

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42

Tyler, Margaret I., Donal Barnett, Philip Nicholson, Ian Spence, and Merlin E. H. Howden. "Studies on the subunit structure of textilotoxin, a potent neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis)." Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 915, no. 2 (1987): 210–16. http://dx.doi.org/10.1016/0167-4838(87)90302-5.

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43

Meier, J., and K. Stocker. "Isolation, characterization and diagnostic potential of texlarin, a prothrombin activator from the venom of the Australian eastern brown snake Pseudonaja textilis." Toxicon 33, no. 3 (1995): 257. http://dx.doi.org/10.1016/0041-0101(95)99232-r.

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44

Rao, Veena S., Sanjay Swarup, and R. Manjunatha Kini. "The nonenzymatic subunit of pseutarin C, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom, shows structural similarity to mammalian coagulation factor V." Blood 102, no. 4 (2003): 1347–54. http://dx.doi.org/10.1182/blood-2002-12-3839.

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Abstract Pseutarin C is a group C prothrombin activator from the venom of the eastern brown snake Pseudonaja textilis. It is a multi-subunit protein complex consisting of catalytic and nonenzymatic subunits similar to coagulation factor Xa and factor Va, respectively. Here we describe the complete sequence of the nonenzymatic subunit. Based on the partial amino acid sequence of the nonenzymatic subunit, degenerate primers were designed. Using a “walking” strategy based on sequentially designed primers, we determined the complete cDNA sequence of the nonenzymatic subunit. The cDNA encodes a pro

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45

Norval, Gerrut, and Michael G. Gardner. "Predation by an Eastern Brownsnake, Pseudonaja textilis (Duméril, Bibron, and Duméril 1854), on a Mallee Black-backed Snake, Parasuta nigriceps (Günther 1863)." Reptiles & Amphibians 25, no. 2 (2018): 134–36. http://dx.doi.org/10.17161/randa.v25i2.14269.

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46

Millers, Emma-Karin I., Manuela Trabi, Paul P. Masci, Martin F. Lavin, John de Jersey, and Luke W. Guddat. "Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)." FEBS Journal 276, no. 11 (2009): 3163–75. http://dx.doi.org/10.1111/j.1742-4658.2009.07034.x.

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47

Webster, C., M. Massaro, D. R. Michael, D. Bambrick, J. L. Riley, and D. G. Nimmo. "Native reptiles alter their foraging in the presence of the olfactory cues of invasive mammalian predators." Royal Society Open Science 5, no. 10 (2018): 180136. http://dx.doi.org/10.1098/rsos.180136.

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Invasive mammalian predators are linked to terrestrial vertebrate extinctions worldwide. Prey naïveté may explain the large impact invasive predators have on native prey; prey may fail to detect and react appropriately to the cues of novel predators, which results in high levels of depredation. In Australia, the feral cat ( Felis catus ) and the red fox ( Vulpes vulpes ) are implicated in more than 30 animal extinctions and the naïveté of native prey is often used to explain this high extinction rate. Reptiles are one group of animals that are heavily preyed upon by F. catus and V. vulpes . Ho

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Gong, NanLing, Arunmozhiarasi Armugam та Kandiah Jeyaseelan. "Molecular cloning, characterization and evolution of the gene encoding a new group of short-chain α-neurotoxins in an Australian elapid, Pseudonaja textilis". FEBS Letters 473, № 3 (2000): 303–10. http://dx.doi.org/10.1016/s0014-5793(00)01549-0.

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Novakovic, Valerie A., Hongzhi Miao, Steven Pipe, and Gary E. Gilbert. "Conservative Mutations in the Membrane-Binding Motif of Factor V C2 Domain to Residues of Pseudonaja Textilis Venom Factor V Confer Phosphatidylserine-Independent Activity." Blood 118, no. 21 (2011): 2243. http://dx.doi.org/10.1182/blood.v118.21.2243.2243.

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Abstract Abstract 2243 Toxicity of venom from the eastern brown snake (Pseudonaja textilis) is related to a prothrombin activator protein complex (pseutarin C) that is homologous to the factor Va/factor Xa complex. A previous study has found that the factor V-homologous subunit of this protein (pt-fV) is constitutively active and does not require anionic membranes to function (Bos et al. 2010, Blood). We have previously found that conservative mutation of the amino acids on the hydrophobic membrane binding regions (called spikes) of factor V (W2063M/W2064F/S2117L) can produce increased prothro

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Triplett, Douglas A., Kurt F. Stocker, Gail A. Unger, and Linda K. Barna. "The Textarin/Ecarin Ratio: A Confirmatory Test for Lupus Anticoagulants." Thrombosis and Haemostasis 70, no. 06 (1993): 0925–31. http://dx.doi.org/10.1055/s-0038-1649701.

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SummaryLupus anticoagulants (LA) are immunoglobulins (IgG, IgM, IgA or a mixture) which interfere with in vitro phospholipid (PL) dependent tests of coagulation (e.g. APTT, KCT, dilute Russell Viper Venom Time). LA are heterogeneous; consequently, the laboratory diagnosis is difficult and relies on multiple tests. We have developed a sensitive and relatively specific confirmatory test system based on fractions of two snake venoms. Textarin®, a protein fraction of Pseudonaja textilis venom (Australian Eastern brown snake), activates prothrombin in the presence of PL, factor V and calcium ions.

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