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Dissertations / Theses on the topic 'Pseudotype'

Author: Grafiati

Published: 14 March 2023

Last updated: 26 July 2025

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1

Strang, Blair Lewis. "Development and characterisation of pseudotype HIV vectors." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406402.

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2

Piccini, Giulia. "Evaluation of Influenza Lentiviral Pseudotypes as an alternative source of antigen in the Neuraminidase Inhibition Enzyme-Linked Lectin Assay." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1096232.

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The continuously changing epidemiology of influenza viruses needs to be yearly addressed with a fast and massive production of vaccines that prevent epidemic outbreaks and occasional pandemics worldwide. Currently licensed flu vaccines are designed to elicit antibodies against the viral hemagglutinin (HA). Formulations containing standardized amounts of neuraminidase (NA) are however gaining growing interest in the influenza vaccine field, as NA‐inhibiting (NI) antibodies have been associated with resistance to disease as well as reduced severity and duration of illness. The Neuraminidase In

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3

Mahoney, Catherine H. "Studies using pseudotyped retroviral vectors." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312721.

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4

Grzybowski, Brad. "A pseudotyped viral vector : hPIV3-HIV-1." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/20932.

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5

Thomas, Joan Helen. "Studies in gene transfer using pseudotyped lentiviral vector systems." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621818.

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6

Gaiano, Nicholas R. (Nicholas Roger). "Insertional mutagenesis in zebrafish using a pseudotyped retroviral vector." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43311.

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7

Peng, Yue. "A novel vaccine strategy : replication-defective pseudotyped SIVs expressing IFN-[gamma] /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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Thesis (Ph. D.)--University of California, Davis, 2005.<br>Degree granted in Comparative Pathology. On title page "[gamma]" appears as lower-case Greek letter. Also available via the World Wide Web. (Restricted to UC campuses)

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8

Kinsley, Rebecca. "Development of lentiviral pseudotypes for surveillance studies on animal influenza viruses." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/66297/.

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Pseudotyped viruses (PVs) provide a safe, flexible platform for fundamental virological studies and antibody screening assays. Generation of influenza PVs involves co-transfection of producer cells with plasmids encoding the necessary viral components. The pseudotype virus neutralisation assay (PVNA) is a sensitive technique to measure protective antibody responses which cause neutralisation of virus particles. Many traditional methodologies, e.g. Haemagglutination Inhibition (HI) and Single Radial Haemolysis (SRH), detect only surface glycoprotein binding antibodies whereas the PVNA quantifie

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9

Carnell, George William. "Development of hybrid haemagglutinin pseudotyped lentiviruses to assess heterosubtypic immunity to influenza." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/66363/.

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The influenza virus still causes hundreds of thousands of deaths globally, on top of morbidity and associated economic burden. We are currently at the height of efforts surrounding the development and employment of 'universal' vaccines against this virus, with clinical trials commencing on the most promising candidates. Despite this, the influenza virus poses more of a threat to human life than it ever has previously, with multiple subtypes of pandemic potential circulating around the globe. The key to current efforts lies in the priming of the immune system towards generating long lasting def

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10

Amsterdam, Adam (Adam Henry) 1967. "Use of a pseudotyped retoviral vector to accomplish insertional mutagenesis in zebrafish." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50024.

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11

Ferrara, Francesca. "Using pseudotypes to study heterosubtypic antibody responses elicted by seasonal influenza vaccination." Thesis, University of Kent, 2015. https://kar.kent.ac.uk/50903/.

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Influenza viruses represent an important public health burden since they cause annual epidemics associated with severe illness and mortality in high-risk populations. Additionally, zoonotic influenza virus infections have potential to produce intermittent pandemics, which have led to millions of deaths globally. However, strategies to prevent influenza severity and spread can be implemented. It is known that antibodies against the haemagglutinin play a key role in protection from influenza virus infection, thus both seasonal and pandemic influenza vaccines aim to elicit such antibodies. Genera

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12

Mather, Stuart Thomas. "Development of pseudotyped virus assays for the serological study of Japanese encephalitis flavivirus." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/62936/.

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Japanese encephalitis virus (JEV) is one of the primary global causes of viral encephalitis, with approximately 68,000 clinical cases and 20,000 deaths attributed to the virus annually. Between 30% and 50% of survivors suffer from debilitating neurological sequelae. Despite being a vaccine-preventable disease, no antiviral treatments are licensed and commercially available to counteract JEV infection. In order to quantify the neutralising antibody response raised against antigenic epitopes on flavivirus prME glycoproteins, conventional serological assays such as the plaque reduction neutralisa

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13

Pfaff, Kerstin [Verfasser]. "Hepatitis-C-Virus-Pseudotypen und deren Einsetzbarkeit in der virologischen Diagnostik / Kerstin Pfaff." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1029850569/34.

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14

Enkirch, Theresa [Verfasser], and Ralf [Akademischer Betreuer] Bartenschlager. "Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins / Theresa Enkirch ; Betreuer: Ralf Bartenschlager." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179783220/34.

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15

Bentley, Emma. "The study of highly pathogenic emerging zoonotic virus envelope proteins through pseudotyped virus generation." Thesis, University of Westminster, 2017. https://westminsterresearch.westminster.ac.uk/item/q4yzx/the-study-of-highly-pathogenic-emerging-zoonotic-virus-envelope-proteins-through-pseudotyped-virus-generation.

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Emerging zoonotic viruses pose an increasing threat, causing outbreaks with high rates of morbidity and mortality and frequently significant economic implications. Often, there is a lack or shortfall of effective prophylaxis and diagnostic capabilities. Research towards their development, together with improved surveillance activities are high priority activities to prepare and respond to outbreak threats. Yet handling these viruses commonly requires high containment levels. This can be circumvented by the use of replication defective pseudotyped viruses (PVs), incorporating the viral envelope

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16

Mao, Jian. "Vesicular stomatitis virus G pseudotyped retrovector mediated gene delivery of connexin43 to brain tumor cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/MQ42173.pdf.

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17

Haynes, Soraya. "Construction of a novel bat coronavirus glycoprotein pseudotyped lentiviral vector and analysis of cell tropism." Thesis, Haynes, Soraya (2019) Construction of a novel bat coronavirus glycoprotein pseudotyped lentiviral vector and analysis of cell tropism. Honours thesis, Murdoch University, 2019. https://researchrepository.murdoch.edu.au/id/eprint/54215/.

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Since the SARS epidemic in 2003, and the subsequent identification of bats as the reservoir host, there has been a surge of interest in research into bat-borne viruses, with over 30 new bat coronaviruses alone being discovered. Investigating the cell tropism of these newly discovered coronaviruses deepens the understanding of their pathology and possible host ranges, as well as allowing assessments to be made on their zoonotic potential. Aside from biosafety concerns however, this is also reliant on isolation of the virus from its host, which can be difficult using conventional methods. Th

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18

Codran, Audrey. "Production de virus pseudotypes VSV/VHC : Etude de la fusion du VHC avec les cellules hôtes." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. https://publication-theses.unistra.fr/public/theses_doctorat/2003/CODRAN_Audrey_2003.pdf.

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En raison de l'absence de système de culture cellulaire capable de propager efficacement le virus de l'hépatite C, peu de données sont disponibles concernant les phases précoces de l'infection. Afin d'étudier la fusion et la pénétration du VHC dans la cellule hôte, nous avons choisi de fabriquer des virus pseudotypes VSV/VHC destinés à mimer l'enveloppe du VHC dans les phases précoces de l'infection. Dans un premier temps, les glycoprotéines d'enveloppe du VHC (E1 et E2) sont modifiées pour être localisées à la membrane plasmique, site de bourgeonnement du VSV. Pour cela, les ectodomaines de E

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19

Sandrin, Virginie. "Aspects fondamental et appliqué des pseudotypes rétroviraux : mécanismes d'assemblage et propriétés pour le transfert de gène." Lyon, École normale supérieure (sciences), 2005. http://www.theses.fr/2005ENSL0311.

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20

Gagnepain, Anaïs. "Évaluation de nouveaux pseudotypes de vecteurs lentiviraux pour le transfert de gènes dans les cellules hématopoiétiques." Thesis, Lyon, École normale supérieure, 2014. http://www.theses.fr/2014ENSL0939/document.

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Le transfert de gènes dans les cellules souches hématopoïétiques par des vecteurs lentiviraux s’inscrit dans les protocoles actuels de traitement par thérapie génique de plusieurs maladies monogéniques (B-thalassémie, Adrénoleucodystrophie, SCID…). De même, le transfert de gènes dans les lymphocytes T et B ouvre des perspectives tant au niveau de la thérapie génique que pour l’immunothérapie. Nous avons mis au point des vecteurs lentiviraux pseudotypés par des glycoprotéines chimérique (BaEV/TR) et mutante (BaEVRLess) du rétrovirus endogène de babouin. Nous avons montré que ces nouveaux vecteu

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21

Ibrahim, Mazher Hassan. "History matching pressure response functions from production data." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1486.

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This dissertation presents several new techniques for the analysis of the long-term production performance of tight gas wells. The main objectives of this work are to determine pressure response function for long-term production for a the slightly compressible liquid case, to determine the original gas in place (OGIP) during pseudosteady state (PSS), to determine OGIP in the transient period, and to determine the effects of these parameters on linear flow in gas wells. Several methods are available in the industry to analyze the production performance of gas wells. One common method is superp

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22

Levy, Camille. "Nouveaux pseudotypes rétroviraux basés sur les glycoprotéines d'enveloppe de paramyxovirus : applications biothérapeutiques en thérapie génique et en vaccinologie." Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0709.

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Les paramyxovirus possèdent deux glycoprotéines d’enveloppe (gps): la protéine F, permettant la fusion avec la cellule hôte, et la protéine d’attachement appelée G, H ou HN. Les gps H et F d’une souche vaccinale du virus de la rougeole peuvent être incorporées sur des vecteurs lentiviraux (H/F-LV) permettant une transduction efficace des lymphocytes T et B humains non stimulés, habituellement réfractaires. Nous avons montré que les vecteurs H/F-LV sont capables de transduire des cellules B cancéreuses, activées et quiescentes, contrairement aux VSV-G-LV classiques. Leur utilisation in vivo est

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23

Islam, Tarin A. "Characterisation of axonal retrograde transport of rabies pseudotyped lentiviral vectors for application in gene therapy of motor neuron diseases." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/25142.

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Lentiviral vectors, such as those derived from Human Immunodeficiency Virus-1 (HIV-1) and Equine Infectious Anaemia Virus (EIAV), can be targeted to the neurons by replacing their natural envelope with rabies-G glycoprotein (RV-G), through a process known as pseudotyping. They are retrogradedly transported to distal projecting neurons in vivo where transgene expression occurs, an approach with significant potential for gene therapy of motor neuron diseases. However, the molecular processes that underlie retrograde transduction are unchartered and barrier(s) which result in low transduction eff

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24

Gollan, Timothy J. "Altering the Tropism of Retroviral Vectors For In Vivo Gene Therapy: Pseudotyped Virus Targeting by Ligand-Receptor Interactions: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/226.

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A potential approach to in vivo gene therapy is to target retrovirus to specific receptors through a ligand-receptor interaction. Previous studies have placed a ligand at or close to the N-terminus of the ecotropic Moloney murine leukemia virus envelope and require co-expression of a wild type envelope on the pseudotyped virus for successful transduction of human cells. In this study, over forty chimeric envelopes were generated, which have single or multiple insertions of a 13 or 21 amino acid RGD containing sequence, flanked by cysteine residues, that target the cellular integrin receptors (

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25

Jäkel, Melanie [Verfasser], and Gerd [Akademischer Betreuer] Sutter. "In vivo characterization of a pseudotyped vesicular stomatitis virus for the treatment of Hepatocellular carcinoma / Melanie Jäkel ; Betreuer: Gerd Sutter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1206096616/34.

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26

Le, Goff Jérôme. "Interactions entre le VIH-1 et l' herpes simplex de type 2 dans le microenvironnement cellulaire et génital." Paris 7, 2005. http://www.theses.fr/2005PA077105.

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27

Coquin, Youna. "Caractérisation de vecteurs lentiviraux pseudotypés par les syncytines murines et de leurs cibles cellulaires in vitro et in vivo." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLE039.

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Les vecteurs lentiviraux (LV) de thérapie génique sont des particules recombinantes qu'il est possible de pseudotyper avec diverses glycoprotéines d'enveloppe afin de modifier l'adressage cellulaire ou leurs propriétés immunogéniques. Mon travail de thèse a exploré l'hypothèse que la VSVG, la glycoprotéine d'enveloppe la plus utilisée pour pseudotyper les LV, puisse être remplacée par des protéines cellulaires afin d'obtenir des particules bien tolérées et administrables in vivo. J'ai utilisé les syncytines murines, qui sont des glycoprotéines d'origine rétrovirale endogène et qui ont des prop

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28

Lim, Chee Yee. "Understanding transcriptional regulation through computational analysis of single-cell transcriptomics." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267786.

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Gene expression is tightly regulated by complex transcriptional regulatory mechanisms to achieve specific expression patterns, which are essential to facilitate important biological processes such as embryonic development. Dysregulation of gene expression can lead to diseases such as cancers. A better understanding of the transcriptional regulation will therefore not only advance the understanding of fundamental biological processes, but also provide mechanistic insights into diseases. The earlier versions of high-throughput expression profiling techniques were limited to measuring average gen

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29

Molina, Rosa-Maria. "Facteurs influençant l'expression de vecteurs rétroviraux dérivés des virus ALSV in vitro : rôle des pseudotypes rétroviraux sur la spécificité tissulaire du transfert de gènes intraembryonnaire chez les oiseaux." Lyon 1, 1994. http://www.theses.fr/1994LYO10097.

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Les animaux transgeniques constituent actuellement un modele particulierement adapte pour de nombreuses etudes in vivo tant en recherche fondamentale qu'en recherche appliquee. Les vecteurs mis au point dans notre laboratoire pour transferer des genes exogenes chez les oiseaux sont derives des retrovirus aviaires alsv et produits en condition helper-free. Ils infectent les cellules permissives et l'information genetique qu'ils vehiculent s'integre efficacement dans le genome cellulaire. Cependant, l'expression stable et efficace des genes transferes depend de multiples facteurs. Ce travail a m

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30

Waern, Johan Martin [Verfasser], and Michael [Akademischer Betreuer] Ott. "Cell-specific infection of human cells mediated by lentiviral vectors pseudotyped with measles virus hemagglutinin fused to single chain antibodies / Johan Martin Waern ; Akademischer Betreuer: Michael Ott ; Klinik für Gastroenterologie, Hepatologie und Endokrinologie der Medizinischen Hochschule Hannover." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://d-nb.info/1151400343/34.

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Waern, Johan [Verfasser], and Michael [Akademischer Betreuer] Ott. "Cell-specific infection of human cells mediated by lentiviral vectors pseudotyped with measles virus hemagglutinin fused to single chain antibodies / Johan Martin Waern ; Akademischer Betreuer: Michael Ott ; Klinik für Gastroenterologie, Hepatologie und Endokrinologie der Medizinischen Hochschule Hannover." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://nbn-resolving.de/urn:nbn:de:gbv:354-2017111580.

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32

Pagliaro, Sarah Beatriz De Oliveira. "Transcriptional control induced by bcr-abl and its role in leukemic stem cell heterogeneity. Single-Cell Transcriptome in Chronic Myeloid Leukemia: Pseudotime Analysis Reveals Evidence of Embryonic and Transitional Stem Cell States Single Cell Transcriptome in Chronic Myeloid Leukemia (CML): Pseudotime Analysis Reveals a Rare Population with Embryonic Stem Cell Features and Druggable Intricated Transitional Stem Cell States A novel neuronal organoid model mimicking glioblastoma (GBM) features from induced pluripotent stem cells (iPSC) Experimental and integrative analyses identify an ETS1 network downstream of BCR-ABL in chronic myeloid leukemia (CML)." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ032.

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La leucémie myéloïde chronique est une hématopoïèse maligne clonale, caractérisée par l'acquisition de la translocation t (9;22) conduisant au chromosome Ph1 et à son homologue l'oncogène BCR-ABL, dans une cellule souche hématopoïétique très primitive. La LMC est un modèle de thérapies ciblées, car il a été démontré que la preuve de la faisabilité du ciblage de l'activité tyrosine kinase (TK) BCR-ABL à l'aide d'inhibiteurs de TK (TKI) entraîne des réponses et des rémissions majeures. Cependant, les problèmes actuels rencontrés dans ces thérapies sont la résistance des cellules souches leucémiq

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33

Lin, Po-Yin, and 林柏吟. "Expressing dengue virus 2 E protein for pseudotype formation of murine leukemia virus with dengue virus envelope." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/35241300985270384102.

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碩士<br>國立交通大學<br>生化工程研究所<br>94<br>Dengue virus (DV), a member of the family Flaviviridae, is an enveloped, single-stranded positive sense RNA virus. Dengue fever and dengue hemorrhagic fever (DF/DHF) are caused by the dengue viruses that represent a global public health problem. In the process of virus entry, the envelope protein (E protein) plays an important role. It is a glycoprotein of 495 amino acids, with a transmembrane domain at the C-terminal. The extracellular domain of E protein is thought to interact with the host cell receptor. There is no discernable change in the host cell that i

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34

Nogueira, Rodrigo José Gameiro. "Pseudotyped lentiviral vectors for gene therapy: impact of envelope glycoproteins." Master's thesis, 2019. http://hdl.handle.net/10362/89669.

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The potential of gene therapy to treat a broad range of diseases, ranging from cancer to monogenic diseases, makes it a powerful approach to address medical needs that are currently unmet by conventional medicine. Lentiviral vectors have been the viral vectors experiencing the highest growth in gene therapy clinical trials due to their large genetic payload, the ability to transduce both dividing and non-dividing cells, permanently integrating into the target cell genome and increased safety when compared to Gammaretrovirus. However, the utilization of lentiviral vectors in gene therapy has be

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35

Núñez, Jisette González. "NON-PATHOGENIC VIRAL VECTORS PSEUDOTYPED WITH THE SARS-COV-2 S PROTEIN TO STUDY DRUG REPURPOSING AND IMMUNIZATION STRATEGIES." Master's thesis, 2021. http://hdl.handle.net/10316/99147.

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Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia<br>O coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2) é o vírus responsável pela doença coronavírus 2019 (COVID-19). Os primeiros casos de SARS-CoV-2 foram reportados na China e, em setembro de 2021, mais de 228 milhões de pessoas foram infectadas e mais de 4 milhões de mortes foram registadas por esta doença. Embora a origem do SARS-CoV-2 ainda seja desconhecida, a explicação mais aceite é um evento zoonótico. O SARS-CoV-2 pertence à família Coronaviridae (ordem Nidovirales), um grupo de v

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36

Drăgan, Anette [Verfasser]. "Entwicklung klinisch charakterisierter HCV-Pseudotypen zur Untersuchung der HCV-assoziierten Kryoglobulinämie und der Virusneutralisierung durch Antikörper / vorgelegt von Anette Drăgan." 2010. http://d-nb.info/1006604464/34.

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Wu, Chia Jen, and 吳嘉仁. "The establishment of pseudotyped adeno-associated virus 2/9-delivered CCL11 shRNA and CC10 gene to alleviate lung inflammation in allergen-sensitized murine model." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/56930458481372748776.

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博士<br>長庚大學<br>生物醫學研究所<br>101<br>Asthma is a chronic airway inflammatory disease characterized by eosinophilic infiltration and airway hyperresponsiveness. The over-activated Th2 and lung epithelial cells express many different cytokines and chemokines that mainly contribute to the severity of lung inflammation. CCL11 (eotaxin-1) is secreted by lung epithelial cells and functions as a major chemokine for eosinophil recruitment. Clara cell 10 kDa protein (CC10) that is highly expressed and secreted from airway epithelial cells and exhibits anti-inflammatory and immunomodulatory effects. Pseudoty

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