Academic literature on the topic 'Pseudotyped virus'

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Journal articles on the topic "Pseudotyped virus"

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Poluri, Ananthalakshmi, Rebecca Ainsworth, Scott C. Weaver, and Richard E. Sutton. "Functional Pseudotyping of Human Immunodeficiency Virus Type 1 Vectors by Western Equine Encephalitis Virus Envelope Glycoprotein." Journal of Virology 82, no. 24 (2008): 12580–84. http://dx.doi.org/10.1128/jvi.01503-08.

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ABSTRACT We investigated the ability of western equine encephalitis virus envelope glycoproteins (WEEV GP) to pseudotype lentiviral vectors. The titers of WEEV GP-pseudotyped human immunodeficiency virus type 1 (HIV) ranged as high as 8.0 × 104 IU/ml on permissive cells. Sera from WEEV-infected mice specifically neutralized these pseudotypes; cell transduction was also sensitive to changes in pH. The host range of the pseudotyped particles in vitro was somewhat limited, which is atypical for most alphaviruses. HIV vectors pseudotyped by WEEV GP may be a useful tool for characterizing WEEV cell
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Chan, Eva, Gabrielle Heilek-Snyder, Nick Cammack, Surya Sankuratri, and Changhua Ji. "Development of a Moloney Murine Leukemia Virus-Based Pseudotype Anti-HIV Assay Suitable for Accurate and Rapid Evaluation of HIV Entry Inhibitors." Journal of Biomolecular Screening 11, no. 6 (2006): 652–63. http://dx.doi.org/10.1177/1087057106288881.

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There has been increasing interest in the identification of novel HIV entry inhibitors. For the discovery of these entry inhibitors, robust surrogate anti-HIV assays are highly desired. The authors report a novel anti-HIV assay system using Moloney murine leukemia viruses (MMLVs) pseudotyped with cytoplasmic tail-truncated HIV envelope protein gp140. These pseudotyped MMLV-HIVgp140 viral particles carry luciferase transcripts; therefore, robust luciferase signal can be detected in cells infected by these pseudotypes. Polycationic agent polybrene and spinoculation markedly enhanced the infectio
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Bruett, Linda, and Janice E. Clements. "Functional Murine Leukemia Virus Vectors Pseudotyped with the Visna Virus Envelope Show Expanded Visna Virus Cell Tropism." Journal of Virology 75, no. 23 (2001): 11464–73. http://dx.doi.org/10.1128/jvi.75.23.11464-11473.2001.

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ABSTRACT Pseudotype virus vectors serve as a powerful tool for the study of virus receptor usage and entry. We describe the development of murine leukemia virus (MuLV) particles pseudotyped with the visna virus envelope glycoprotein and encoding a green fluorescent protein reporter as a tool to study the expression of the visna virus receptor. Functional MuLV/visna virus pseudotypes were obtained when the cytoplasmic tail of the visna virus envelope TM protein was truncated to 3, 7, or 11 amino acids in length. MuLV/visna virus particles were used to transduce a panel of cell types from variou
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Balliet, John W., and Paul Bates. "Efficient Infection Mediated by Viral Receptors Incorporated into Retroviral Particles." Journal of Virology 72, no. 1 (1998): 671–76. http://dx.doi.org/10.1128/jvi.72.1.671-676.1998.

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ABSTRACT Many host cell surface proteins, including viral receptors, are incorporated into enveloped viruses. To address the functional significance of these host proteins, murine leukemia viruses containing the cellular receptors for Rous sarcoma virus (Tva) or ecotropic murine leukemia virus (MCAT-1) were produced. These receptor-pseudotyped viruses efficiently infect cells expressing the cognate viral envelope glycoproteins, with titers of up to 105 infectious units per milliliter for the Tva pseudotypes. Receptor and viral glycoprotein specificity and functional requirements are maintained
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Grunwald, Vivien, Hai Dang Ngo, Jan Patrick Formanski, et al. "Development of Zika Virus E Variants for Pseudotyping Retroviral Vectors Targeting Glioblastoma Cells." International Journal of Molecular Sciences 24, no. 19 (2023): 14487. http://dx.doi.org/10.3390/ijms241914487.

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A fundamental idea for targeting glioblastoma cells is to exploit the neurotropic properties of Zika virus (ZIKV) through its two outer envelope proteins, prM and E. This study aimed to develop envelope glycoproteins for pseudotyping retroviral vectors that can be used for efficient tumor cell infection. Firstly, the retroviral vector pNLlucAM was packaged using wild-type ZIKV E to generate an E-HIVluc pseudotype. E-HIVluc infection rates for tumor cells were higher than those of normal prME pseudotyped particles and the traditionally used vesicular stomatitis virus G (VSV-G) pseudotypes, indi
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Su, RuiJun, Rency L. Rosales, Martin Lochelt, and Neil C. Josephson. "Transduction of Primate Cells with Feline Foamy Virus Envelope Pseudotyped Prototype Foamy Virus Vectors." Blood 104, no. 11 (2004): 5276. http://dx.doi.org/10.1182/blood.v104.11.5276.5276.

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Abstract Because of their genetic and biological similarity to humans, non-human primates are the best pre-clinical models for testing the efficacy and safety of gene therapy systems. However, the presence of endogenous simian foamy virus infection in nearly all non-human primates kept in captivity complicates foamy virus (FV) vector stem cell transduction studies in these animals. A major concern is that repopulating cells exposed to FV vector stocks will elicit an immune response in non-human primate hosts. Though human serum does not inactivate prototype foamy virus (PFV) vectors, a one hou
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Zhang, Xian-Yang, Vincent F. La Russa, and Jakob Reiser. "Transduction of Bone-Marrow-Derived Mesenchymal Stem Cells by Using Lentivirus Vectors Pseudotyped with Modified RD114 Envelope Glycoproteins." Journal of Virology 78, no. 3 (2004): 1219–29. http://dx.doi.org/10.1128/jvi.78.3.1219-1229.2004.

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ABSTRACT Bone-marrow-derived mesenchymal stem cells (MSCs) have attracted considerable attention as tools for the systemic delivery of therapeutic proteins in vivo, and the ability to efficiently transfer genes of interest into such cells would create a number of therapeutic opportunities. We have designed and tested a series of human immunodeficiency virus type 1 (HIV-1)-based vectors and vectors based on the oncogenic murine stem cell virus to deliver and express transgenes in human MSCs. These vectors were pseudotyped with either the vesicular stomatitis virus G (VSV-G) glycoprotein (GP) or
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Spiegel, Martin, Michael Bitzer, Andrea Schenk, et al. "Pseudotype Formation of Moloney Murine Leukemia Virus with Sendai Virus Glycoprotein F." Journal of Virology 72, no. 6 (1998): 5296–302. http://dx.doi.org/10.1128/jvi.72.6.5296-5302.1998.

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ABSTRACT Mixed infection of cells with both Moloney murine leukemia virus (MoMLV) and related or heterologous viruses produces progeny pseudotype virions bearing the MoMLV genome encapsulated by the envelope of the other virus. In this study, pseudotype formation between MoMLV and the prototype parainfluenza virus Sendai virus (SV) was investigated. We report for the first time that SV infection of MoMLV producer cells results in the formation of MoMLV(SV) pseudotypes, which display a largely extended host range compared to that of MoMLV particles. This could be associated with SV hemagglutini
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Kang, Yubin, Colleen S. Stein, Jason A. Heth, et al. "In Vivo Gene Transfer Using a Nonprimate Lentiviral Vector Pseudotyped with Ross River Virus Glycoproteins." Journal of Virology 76, no. 18 (2002): 9378–88. http://dx.doi.org/10.1128/jvi.76.18.9378-9388.2002.

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ABSTRACT Vectors derived from lentiviruses provide a promising gene delivery system. We examined the in vivo gene transfer efficiency and tissue or cell tropism of a feline immunodeficiency virus (FIV)-based lentiviral vector pseudotyped with the glycoproteins from Ross River Virus (RRV). RRV glycoproteins were efficiently incorporated into FIV virions, generating preparations of FIV vector, which after concentration attain titers up to 1.5 × 108 TU/ml. After systemic administration, RRV-pseudotyped FIV vectors (RRV/FIV) predominantly transduced the liver of recipient mice. Transduction effici
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Sandrin, Virginie, Bertrand Boson, Patrick Salmon, et al. "Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates." Blood 100, no. 3 (2002): 823–32. http://dx.doi.org/10.1182/blood-2001-11-0042.

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Abstract Generating lentiviral vectors pseudotyped with different viral glycoproteins (GPs) may modulate the physicochemical properties of the vectors, their interaction with the host immune system, and their host range. We have investigated the capacity of a panel of GPs of both retroviral (amphotropic murine leukemia virus [MLV-A]; gibbon ape leukemia virus [GALV]; RD114, feline endogenous virus) and nonretroviral (fowl plague virus [FPV]; Ebola virus [EboV]; vesicular stomatitis virus [VSV]; lymphocytic choriomeningitis virus [LCMV]) origins to pseudotype lentiviral vectors derived from sim
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Dissertations / Theses on the topic "Pseudotyped virus"

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Bentley, Emma. "The study of highly pathogenic emerging zoonotic virus envelope proteins through pseudotyped virus generation." Thesis, University of Westminster, 2017. https://westminsterresearch.westminster.ac.uk/item/q4yzx/the-study-of-highly-pathogenic-emerging-zoonotic-virus-envelope-proteins-through-pseudotyped-virus-generation.

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Emerging zoonotic viruses pose an increasing threat, causing outbreaks with high rates of morbidity and mortality and frequently significant economic implications. Often, there is a lack or shortfall of effective prophylaxis and diagnostic capabilities. Research towards their development, together with improved surveillance activities are high priority activities to prepare and respond to outbreak threats. Yet handling these viruses commonly requires high containment levels. This can be circumvented by the use of replication defective pseudotyped viruses (PVs), incorporating the viral envelope
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Grzybowski, Brad. "A pseudotyped viral vector : hPIV3-HIV-1." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/20932.

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Mather, Stuart Thomas. "Development of pseudotyped virus assays for the serological study of Japanese encephalitis flavivirus." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/62936/.

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Japanese encephalitis virus (JEV) is one of the primary global causes of viral encephalitis, with approximately 68,000 clinical cases and 20,000 deaths attributed to the virus annually. Between 30% and 50% of survivors suffer from debilitating neurological sequelae. Despite being a vaccine-preventable disease, no antiviral treatments are licensed and commercially available to counteract JEV infection. In order to quantify the neutralising antibody response raised against antigenic epitopes on flavivirus prME glycoproteins, conventional serological assays such as the plaque reduction neutralisa
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Mao, Jian. "Vesicular stomatitis virus G pseudotyped retrovector mediated gene delivery of connexin43 to brain tumor cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/MQ42173.pdf.

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Gollan, Timothy J. "Altering the Tropism of Retroviral Vectors For In Vivo Gene Therapy: Pseudotyped Virus Targeting by Ligand-Receptor Interactions: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/226.

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A potential approach to in vivo gene therapy is to target retrovirus to specific receptors through a ligand-receptor interaction. Previous studies have placed a ligand at or close to the N-terminus of the ecotropic Moloney murine leukemia virus envelope and require co-expression of a wild type envelope on the pseudotyped virus for successful transduction of human cells. In this study, over forty chimeric envelopes were generated, which have single or multiple insertions of a 13 or 21 amino acid RGD containing sequence, flanked by cysteine residues, that target the cellular integrin receptors (
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Jäkel, Melanie [Verfasser], and Gerd [Akademischer Betreuer] Sutter. "In vivo characterization of a pseudotyped vesicular stomatitis virus for the treatment of Hepatocellular carcinoma / Melanie Jäkel ; Betreuer: Gerd Sutter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1206096616/34.

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Waern, Johan Martin [Verfasser], and Michael [Akademischer Betreuer] Ott. "Cell-specific infection of human cells mediated by lentiviral vectors pseudotyped with measles virus hemagglutinin fused to single chain antibodies / Johan Martin Waern ; Akademischer Betreuer: Michael Ott ; Klinik für Gastroenterologie, Hepatologie und Endokrinologie der Medizinischen Hochschule Hannover." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://d-nb.info/1151400343/34.

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Waern, Johan [Verfasser], and Michael [Akademischer Betreuer] Ott. "Cell-specific infection of human cells mediated by lentiviral vectors pseudotyped with measles virus hemagglutinin fused to single chain antibodies / Johan Martin Waern ; Akademischer Betreuer: Michael Ott ; Klinik für Gastroenterologie, Hepatologie und Endokrinologie der Medizinischen Hochschule Hannover." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://nbn-resolving.de/urn:nbn:de:gbv:354-2017111580.

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Codran, Audrey. "Production de virus pseudotypes VSV/VHC : Etude de la fusion du VHC avec les cellules hôtes." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. https://publication-theses.unistra.fr/public/theses_doctorat/2003/CODRAN_Audrey_2003.pdf.

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En raison de l'absence de système de culture cellulaire capable de propager efficacement le virus de l'hépatite C, peu de données sont disponibles concernant les phases précoces de l'infection. Afin d'étudier la fusion et la pénétration du VHC dans la cellule hôte, nous avons choisi de fabriquer des virus pseudotypes VSV/VHC destinés à mimer l'enveloppe du VHC dans les phases précoces de l'infection. Dans un premier temps, les glycoprotéines d'enveloppe du VHC (E1 et E2) sont modifiées pour être localisées à la membrane plasmique, site de bourgeonnement du VSV. Pour cela, les ectodomaines de E
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Pfaff, Kerstin [Verfasser]. "Hepatitis-C-Virus-Pseudotypen und deren Einsetzbarkeit in der virologischen Diagnostik / Kerstin Pfaff." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1029850569/34.

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Book chapters on the topic "Pseudotyped virus"

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Zhang, Leiliang, Xiao Wang, Annan Ming, and Wenjie Tan. "Pseudotyped Virus for Flaviviridae." In Advances in Experimental Medicine and Biology. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0113-5_17.

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Chen, Ruifeng, Weijing Huang, and Youchun Wang. "Pseudotyped Virus for Bandavirus." In Advances in Experimental Medicine and Biology. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0113-5_14.

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Li, Tao, Ziteng Liang, Weijin Huang, and Youchun Wang. "Pseudotyped Virus for Henipavirus." In Advances in Experimental Medicine and Biology. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0113-5_9.

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Wu, Xueling, Jianhui Nie, and Youchun Wang. "Pseudotyped Virus for Papillomavirus." In Advances in Experimental Medicine and Biology. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0113-5_5.

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Wu, Jiajing, Weijin Huang, and Youchun Wang. "Pseudotyped Viruses for the Alphavirus Chikungunya Virus." In Advances in Experimental Medicine and Biology. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0113-5_16.

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Rupil, Lucía Lara, Marianela del Carmen Serradell, and Hugo Daniel Luján. "Production of Based on Virus-Like Particles Pseudotyped with." In Vaccine Design. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1884-4_26.

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Fukushi, Shuetsu, Rie Watanabe, and Fumihiro Taguchi. "Pseudotyped Vesicular Stomatitis Virus for Analysis of Virus Entry Mediated by SARS Coronavirus Spike Proteins." In Methods in Molecular Biology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-181-9_23.

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Fukushi, Shuetsu, Tetsuya Mizutani, Masayuki Saijo, et al. "Pseudotyped Vesicular Stomatitis Virus for Functional Analysis of Sars Coronavirus Spike Protein." In Advances in Experimental Medicine and Biology. Springer US, 2006. http://dx.doi.org/10.1007/978-0-387-33012-9_50.

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Kameyama, Yujiro, Yoshinori Kawabe, Akira Ito, and Masamichi Kamihira. "Retroviral Vectors Pseudotyped with Chimeric Vesicular Stomatitis Virus Glycoprotein for Antibody-Dependent Gene Transduction." In Basic and Applied Aspects. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3892-0_30.

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Brouillette, Rachel B., and Wendy Maury. "Production of Filovirus Glycoprotein-Pseudotyped Vesicular Stomatitis Virus for Study of Filovirus Entry Mechanisms." In Ebolaviruses. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7116-9_4.

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Conference papers on the topic "Pseudotyped virus"

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Taveira, Elisa Borges, Marco Fidel Guevara-Vega, Igor Andrade Santos, et al. "SARS-CoV-2 structures detection in artificial saliva using ATR-FTIR associated with Linear Discriminant Analysis." In Latin America Optics and Photonics Conference. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/laop.2022.tu1c.8.

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Here, we used ATR-FTIR platform supported by artificial intelligence algorithms to identify unique infrared vibrational modes of a pseudotyped human immunodeficiency virus type-1 (HIV-1) coupled to Spike (S) protein of SARS-CoV-2 (HIV/NanoLuc-SARS-CoV-2 pseudotype virus).
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Tishin, A. E., O. I. Yarovaya, S. S. Efstifeeva, A. R. Imatdinov, and I. R. Imatdinov. "MINIGENOMIC AND PSEUDOTYPED SYSTEMS FOR SCREENING COMPOUNDS WITH ANTIVIRAL ACTIVITY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-262.

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This research describes approaches and genetic constructs used for high-performance screening studies of organic compounds exhibiting inhibitory activity against the replication-transcription machinery of the Puumala virus.
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Urbiola, Carles Rodriguez, Catherine Dold, Janine Kimpel, et al. "Abstract A191: Augmenting the therapeutic efficacy of oncolytic LCMV-GP pseudotyped vesicular stomatitis virus via modulation of the innate immune system." In Abstracts: CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-a191.

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Henderson, John, Ruediger Gross, Sterghios Moschos, et al. "Late Breaking Abstract - Capture efficiency of mechanically nebulised synthetic nanoparticles, liposomes, SARS-CoV-2 virus-like particles, and infectious pseudotyped virions is influenced by particle surface charge." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa2368.

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