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Journal articles on the topic 'PSLE'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Ferdous, Ellen, Sanjida Parvin Sonia, Mohammed Mahbubul Islam, Manik Kumar Talukder, and Mohammad Imnul Islam. "Relation of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) with Renal Involvement in Pediatric Systemic Lupus Erythematosus Patients." Paediatric Nephrology Journal of Bangladesh 9, no. 1 (2024): 17–21. http://dx.doi.org/10.4103/pnjb.pnjb_3_24.

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Background: Approximately 60%–80% of pediatric systemic lupus erythematosus (pSLE) patients have renal involvement during their disease course. Several potential urinary biomarkers have been identified to predict renal involvement. Among them, urinary neutrophil gelatinase-associated lipocalin (NGAL) has been associated with renal involvement, renal flare, and disease activity in pSLE patients. Objective: This study aims to assess the urinary NGAL levels and its association with renal involvement in pSLE patients. Materials and Methods: This cross-sectional study was conducted in the Paediatri

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Hui-Yuen, Joyce, Kaiyu Jiang, Susan Malkiel, et al. "B lymphocytes in treatment-naive paediatric patients with lupus are epigenetically distinct from healthy children." Lupus Science & Medicine 10, no. 1 (2023): e000921. http://dx.doi.org/10.1136/lupus-2023-000921.

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BackgroundSLE is likely triggered by gene–environment interactions. We have shown that most SLE-associated haplotypes encompass genomic regions enriched for epigenetic marks associated with enhancer function in lymphocytes, suggesting genetic risk is exerted through altered gene regulation. Data remain scarce on how epigenetic variance contributes to disease risk in paediatric SLE (pSLE). We aim to identify differences in epigenetically regulated chromatin architecture in treatment-naive patients with pSLE compared with healthy children.MethodsUsing the assay for transposase-accessible chromat

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Guardino, Katrina, Malaya Gaerlan, Caitlan S. Pinotti, et al. "Meeting report: patient and caregiver recommendations for a mobile health application for paediatric systemic lupus erythematosus." Lupus Science & Medicine 11, no. 2 (2024): e001305. http://dx.doi.org/10.1136/lupus-2024-001305.

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Paediatric systemic lupus erythematosus (pSLE) management and research could be enhanced by a mobile health application (app); however, no app designed for pSLE is currently available. A development and design committee comprising of patients, parents/caregivers and other stakeholders met to inform development and design of an app specific for pSLE. This meeting report summarises the group’s discussions and recommendations that could help create a useful and desirable app or mobile health tool for the pSLE community.

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Joo, Hyejin, Jeongwon Kim, Seohyun Nam, Haeun Chung, Youngtae Kim, and Dongsun Yim. "A Preliminary Study on the Reliability and Validity of the Web-based Parent Screening of Language and Emotion." Korean Journal of Special Education 58, no. 4 (2024): 153–73. http://dx.doi.org/10.15861/kjse.2024.58.4.153.

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This study investigated the language development assessed by the Web-based Parent Screening of Language and Emotion (PSLE), a parent-reported screening test that is available online. The PSLE is designed to evaluate the language development of children in diverse linguistic and cultural environments and identify risk groups. The research aimed to validate the reliability of the test questions across different age groups and domains, as well as to establish correlations with traditional standardized language evaluations. A total of 24 children in the age range of three to nine years and their p

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Afzali, Parisa, Anna Isaeian, Peyman Sadeghi, et al. "Complement deficiency in pediatric-onset systemic lupus erythematosus." Journal of Laboratory Physicians 10, no. 02 (2018): 232–36. http://dx.doi.org/10.4103/jlp.jlp_171_17.

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Abstract BACKGROUND: Pediatric-onset systemic lupus erythematosus (pSLE) accounts for about 10%-20% of all patients with SLE. Deficiencies in early complement components of the classical pathway are the strong genetic risk factor for the development of SLE. In this study, clinical and laboratory manifestations of both complement-deficient and normal complement pSLE patients were compared. MATERIALS AND METHODS: To investigate clinical and immunological manifestations of pSLE in Iran, 36 consecutive pSLE patients (onset before 18 years) who were followed up over a period of 2 years, were studie

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Orjuela, Alvaro, Adisak Suwanichkul, Debra Canter, et al. "High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus." American Journal of Nephrology 41, no. 3 (2015): 241–47. http://dx.doi.org/10.1159/000381965.

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Background/Aims: There is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (SLE). Recent studies in a model mouse and an adult SLE patient cohort suggest that anti-basement membrane antibody levels correlate well with lupus activity and kidney injury. The purpose of this study was to assess the anti-basement membrane reactivity in pediatric SLE (pSLE) patients with or without nephritis. Methods: Auto-antibodies to basement membrane antigens were assessed using an anti-matrigel ELISA. Endpoint titers were measured in pSLE patien

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Bulala, Tapela, and Marea Mbisana. "Validity of Standard Four Attainment Scores in Predicting Agriculture Primary School Leaving Examination Results." Journal of Agriculture and Crops, no. 59 (September 15, 2019): 172–77. http://dx.doi.org/10.32861/jac.59.172.177.

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Establishing how current academic performance relates to future performance is key to helping educators fine tuning their assessment practice. At present high failure rate of Agriculture subject at Primary Leaving Examination (PSLE) has been of a great concern in Botswana. To determine the relationship between the standard four attainment scores and Primary Leaving Examination scores key in tracing the origin of failure observed at primary school leaving examination. The main focus of this study was to determine the validity of standard four attainment scores in predicting performance at stand

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HIRAKI, LINDA T., SUSANNE M. BENSELER, PASCAL N. TYRRELL, ELIZABETH HARVEY, DIANE HEBERT, and EARL D. SILVERMAN. "Ethnic Differences in Pediatric Systemic Lupus Erythematosus." Journal of Rheumatology 36, no. 11 (2009): 2539–46. http://dx.doi.org/10.3899/jrheum.081141.

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Objective.Prevalence and severity of systemic lupus erythematosus (SLE) in adults is suggested to be distinctly different between ethnic groups. The impact of ethnicity is not as well delineated in pediatric SLE (pSLE). We compared prevalence and extent of major organ involvement, disease activity, and damage in pSLE between different ethnic groups.Methods.Ethnic demographic profiles of an inception cohort of 265 patients with pSLE followed at Sick Kids Hospital in Toronto were determined and compared to the Metropolitan Toronto at-risk population. Patients were categorized into ethnic subsets

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Toledano, Helen, Naama Orenstein, Efrat Sofrin, et al. "Paediatric systemic lupus erythematosus as a manifestation of constitutional mismatch repair deficiency." Journal of Medical Genetics 57, no. 7 (2019): 505–8. http://dx.doi.org/10.1136/jmedgenet-2019-106303.

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Biallelic mutations in any of the four mismatch repair genes MSH2, MSH6, MLH1 and PMS2 result in one of the most aggressive childhood cancer predisposition syndromes, termed constitutional mismatch repair deficiency (CMMRD) syndrome. In addition to a very high tumour risk, the CMMRD phenotype is often characterised by the presence of signs reminiscent of neurofibromatosis type 1. Although paediatric systemic lupus erythematosus (pSLE) has been reported so far in three patients with CMMRD, it has not been considered a diagnostic feature of the syndrome. We report here two additional female pati

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Ciurtin, C., J. Peng, P. Donnes, et al. "LB0004 Paediatric Systemic Lupus Erythematosus (pSLE) patient stratification and high-performance serum biomarkers identified responders to statin and patients with high cardiovascular risk in the APPLE trial (Atorvastatin for Atherosclerosis Progression in Paediatric Systemic Lupus Erythematosus)." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 202.2–202. http://dx.doi.org/10.1136/annrheumdis-2023-eular.7032.

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BackgroundPaediatric Systemic Lupus Erythematosus (pSLE) is associated with increased risk of atherosclerosis compared to adult-onset SLE. The APPLE trial is the largest investigator-led randomised control trial in pSLE, which tested the effect of atorvastatin vs. placebo for prevention of atherosclerosis progression over 36 months, using carotid intima-media thickness (CIMT) as primary outcome.ObjectivesWe aimed to investigate:1. patient stratification strategies to identify responders to statin in a trial which did not meet the primary outcome as well as.2. novel high-performance biomarkers

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Mosaad, Y. M., A. Hammad, A. A. Elghzaly, et al. "GATA3 rs3824662 gene polymorphism as possible risk factor for systemic lupus erythematosus." Lupus 27, no. 13 (2018): 2112–19. http://dx.doi.org/10.1177/0961203318804894.

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Background There is no report about the association between GATA3 rs3824662 polymorphism and systemic lupus erythematosus (SLE). Objective To investigate the possible role of GATA3 rs3824662 polymorphism as a susceptibility risk factor for either adult SLE (aSLE) or pediatric SLE (pSLE) and to evaluate its role in the development of lupus nephritis (LN) in pSLE. Methods Typing of GATA3 rs3824662 polymorphism was done using real-time polymerase chain reaction for three groups; 104 pSLE patients, 140 aSLE patients and 436 age- and sex-matched healthy controls. Results Non-significant differences

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Farkas, Oana-Maria, Sigrid Covaci, and Alexis-Virgil Cochino. "PARTICULARITIES OF PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS – LITERATURE REVIEW." Romanian Journal of Rheumatology 26, no. 1 (2017): 5–7. http://dx.doi.org/10.37897/rjr.2017.1.1.

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Pediatric Systemic Lupus Erythematosus (pSLE) is a complex autoimmune disease with onset of symptoms before 18 years of age, accounting for 18-20% of all SLE cases. Although the American College of Rheumatology (ACR) classification criteria and the SLICC (Systemic Lupus International Collaborating Clinics) classification criteria for adults with SLE are commonly applied to pSLE, its clinical onset is different. Renal and neurological involvement tend to be more common and more severe in pediatric population as compared to adults, being therefore major determinants of prognosis and mortality. R

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Elkoumi, M. A., A. A. Emam, M. A. N. Allah, et al. "Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study." Lupus 28, no. 8 (2019): 995–1002. http://dx.doi.org/10.1177/0961203319856089.

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Background Pediatric-onset SLE (pSLE) is a multisystem autoimmune disease. Recently, the ficolin-2 (FCN2) gene has emerged as a potential candidate gene for susceptibility to SLE. Objectives The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions −986 (G/A), −602 (G/A), −4 (A/G) and SNP C/T (rs3124954) located in intron 1, with susceptibility to pSLE in Egyptian children and adolescents. Methods This was a multicenter study of 280 patients diagnosed with pSLE, and 280 well-matched healthy controls. The FCN2 promoter polymorphisms at –986 G/A (rs3

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Dossybayeva, Kuanysh, Yergali Bexeitov, Zaure Mukusheva, et al. "Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus." Diagnostics 12, no. 7 (2022): 1701. http://dx.doi.org/10.3390/diagnostics12071701.

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Basophils are the least abundant circulating leukocytes, and their immunological role has not yet been completely elucidated. There is evidence supporting their immunomodulatory role in several pathological settings; recently, studies in both experimental models and humans suggested that basophil homeostasis may be altered in systemic lupus erythematosus (SLE). Here, we first assessed circulating basophils in children affected with pediatric SLE (pSLE). In this cross-sectional study, circulating basophils were enumerated by fluorescence-based flow cytometry analysis in children affected with p

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Lim, Lily Siok Hoon, Arlette Lefebvre, Susanne Benseler, Michelle Peralta, and Earl D. Silverman. "Psychiatric Illness of Systemic Lupus Erythematosus in Childhood: Spectrum of Clinically Important Manifestations." Journal of Rheumatology 40, no. 4 (2012): 506–12. http://dx.doi.org/10.3899/jrheum.120675.

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Objective.To determine the spectrum of manifestations in clinically important (i.e., requiring alterations of immunosuppressive therapy) psychiatric illness of pediatric systemic lupus erythematosus (pSLE) and to describe the laboratory and imaging features associated with psychiatric illness of pSLE (psySLE).Methods.This was a single-center cohort study of patients with pSLE followed at a pediatric SLE clinic from August 1985 to July 2009. Patients with organic psychiatric disease due to SLE were included. Data regarding psychiatric features at initial presentation and during followup were ob

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Hui-Yuen, J. S., Y. Gartshteyn, M. Ma, et al. "Cell-bound complement activation products (CB-CAPs) have high sensitivity and specificity in pediatric-onset systemic lupus erythematosus and correlate with disease activity." Lupus 27, no. 14 (2018): 2262–68. http://dx.doi.org/10.1177/0961203318809181.

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Objective Elevated levels of cell-bound complement activation products (CB-CAPs) (C4d deposition on B lymphocytes (BC4d) and/or erythrocytes (EC4d)) are sensitive and specific in diagnosis and monitoring of adult systemic lupus erythematosus (SLE). Our objective was to evaluate the role of CB-CAPs for diagnosis and monitoring of pediatric-onset SLE (pSLE). Methods A prospective cohort study of 28 pSLE and 22 juvenile arthritis patients was conducted. SLE disease activity was determined using a clinical Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) that excluded serologies. Autoa

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Huang, Yung-Chieh, Yong-Chen Hsu, Jun-Pen Chen, and Lin-Shien Fu. "The Role of New 3D Pathology and Lymphocyte Expression of Interstitial Inflammation in Pediatric-Onset Lupus Nephritis." International Journal of Molecular Sciences 24, no. 4 (2023): 3512. http://dx.doi.org/10.3390/ijms24043512.

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Lupus nephritis (LN) is a common and severe manifestation of pediatric-onset systemic lupus erythematosus (pSLE). It is one of the major causes of long-term glucocorticoid/immune suppressants use in pSLE. It causes long-term glucocorticoid/immune suppressants use and even end-stage renal disease (ESRD) in pSLE. It is now well known that high chronicity, especially the tubulointerstitial components in the renal biopsy, predicts a poor renal outcome. Interstitial inflammation (II), a component of activity in LN pathology, can be an early predictor for the renal outcome. With the advent of 3D pat

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Manna, Debabrata, Suparna Guha, Sumita Basu, Samar Ranjan Pal, Priyankar Pal, and Ajitesh Roy. "Bone mineral density in children with systemic lupus erythematosus and juvenile idiopathic arthritis: A cross-sectional study in a tertiary care hospital from Eastern India." Sri Lanka Journal of Child Health 53, no. 3 (2024): 223–29. http://dx.doi.org/10.4038/sljch.v53i3.10917.

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Objectives: To determine the Bone Mineral Density (BMD) of paediatric Systemic Lupus Erythematosus (pSLE) and Juvenile Idiopathic Arthritis (JIA) patients and determine its association with predefined variables.Method: This was a cross-sectional study involving consecutive pSLE and JIA patients attending the paediatric rheumatology clinic. Healthy age and sex matched controls were selected from neighbouring schools. BMD was assessed at the lumbar spine by Dual Energy X-ray Absorptiometry (DEXA) scan and expressed as Z-score. Its correlation with variables like Body Mass Index (BMI), onset of p

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Singh, Anupama, Ishani Saha, Sadhvik Karri Siva, Amit Ranjan Rup, Swarnalata Das, and Nirmal Kumar Mohakud. "Systemic lupus erythematosus in an adolescent male: A rare case presentation." Journal of Integrative Medicine and Research 3, no. 1 (2025): 39–43. https://doi.org/10.4103/jimr.jimr_84_24.

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Abstract Pediatric systemic lupus erythematosus (pSLE) is a rare but severe autoimmune condition with multisystem involvement, disproportionately affecting females. Here, we report the case of a 15-year-old male presenting with polyarthralgia, fatigue, and intermittent fever, accompanied by photosensitive skin rash, oral ulcers, and nonproductive cough. Examination revealed a malar rash sparing the nasolabial fold, hard palate ulcers, and a palpable purpuric rash. Initial investigations demonstrated bicytopenia, elevated inflammatory markers, and liver enzyme derangements. Autoimmune workup co

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JURENCÁK, ROMAN, MARVIN FRITZLER, PASCAL TYRRELL, LINDA HIRAKI, SUSANNE BENSELER, and EARL SILVERMAN. "Autoantibodies in Pediatric Systemic Lupus Erythematosus: Ethnic Grouping, Cluster Analysis, and Clinical Correlations." Journal of Rheumatology 36, no. 2 (2009): 416–21. http://dx.doi.org/10.3899/jrheum.080588.

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Objective.(1) To evaluate the spectrum of serum autoantibodies in pediatric-onset systemic lupus erythematosus (pSLE) with a focus on ethnic differences; (2) using cluster analysis, to identify patients with similar autoantibody patterns and to determine their clinical associations.Methods.A single-center cohort study of all patients with newly diagnosed pSLE seen over an 8-year period was performed. Ethnicity, clinical, and serological data were prospectively collected from 156/169 patients (92%). The frequencies of 10 selected autoantibodies among ethnic groups were compared. Cluster analysi

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Abdwani, R., E. Abdalla, and I. Al-Zakwani. "Unique Characteristics of Prepubertal Onset Systemic Lupus Erythematosus." International Journal of Pediatrics 2019 (May 27, 2019): 1–7. http://dx.doi.org/10.1155/2019/9537065.

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Objectives. The aim of this study was to investigate the influence of age at disease onset on disease expression and outcomes of pediatric systemic lupus erythematosus SLE (pSLE). Methods. A total of 103 patients with pSLE from Sultan Qaboos University Hospital, Oman, were retrospectively studied. Epidemiological, clinical phenotype, disease severity, serology, treatment, and outcome were compared among the three groups using univariate statistical tests. Results. The mean disease duration of the cohort was 9.8 ± 4.7 years. The patients were divided into three groups: prepubertal onset (n=39)

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Rahman, Shahana A., Mohammad Imnul Islam, Manik Kumar Talukder, Mohammed Mahbubul Islam, Syed Saimul Huque, and Ranjit Ranjan Roy. "Presentation of Childhood Systemic Lupus Erythematosus in a Tertiary Care Hospital." Bangladesh Journal of Child Health 38, no. 3 (2015): 124–29. http://dx.doi.org/10.3329/bjch.v38i3.22819.

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Background: Systemic lupus erythematosus in children (Paediatric SLE / pSLE) may have a great variability in disease presentation. Any organ system can be involved in pSLE leading to protean clinical manifestations.To evaluate the clinical and serological presentation of pSLE in tertiary renter Bangladesh and to compare it with other populations. Methodology: It was a retrospective cohort study carried out in the department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka during the period of January 2005 to December 2013. A total of 70 patients fulfilling the 1997 revised AC

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Muhammad Ilham Wira Tri Putra and Asra Dewita Namora Harahap. "The Analysis Study of Effectiveness and Safety of Rituximab in The Management of Pediatric Systemic Lupus Erythematosus: A Systematic Review." Indonesian Journal of General Medicine 9, no. 1 (2025): 17–34. https://doi.org/10.70070/yy7a4p83.

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Background: Pediatric systemic lupus erythematosus (pSLE) is a chronic autoimmune disease with an incidence of 0.3–0.9 per 100,000 children per year. Despite growing interest in RTX as a therapeutic option, its use in pSLE remains off-label, and its efficacy and safety have not been well established in this population. This systematic review aims to assess the effectiveness and safety of RTX in children with pSLE based on literatures of the last decade. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2015 to 2025. Editorials, duplicate reviews f

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Jaworski, Marek. "Methods of Step-Size Distribution Optimization Used in S-SSFM Simulations of WDM Systems." Journal of Telecommunications and Information Technology, no. 1 (June 26, 2023): 44–50. http://dx.doi.org/10.26636/jtit.2009.1.913.

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Brief review of methods used for simulation of signal propagation in wavelength division multiplexed (WDM)links is presented. We propose two novel methods of stepsize distribution optimization used to improve symmetrized split step Fourier method (S-SSFM) numerical efficiency: presimulated local error S-SSFM (PsLE S-SSFM) and modified logarithmic (ML S-SSFM). The PsLE S-SSFM contains two stages: in the initial stage step-size distribution optimization is carried out by combining local error method and presimulation with signal spectrum averaging; in the second stage conventional SSFM is used b

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R. Boladola, Brenda, and Marilou R. Gallos. "Grade 10 Students’ Perception of Learning Environment: Prospects for K to12 Science Teaching Enhancement." International Multidisciplinary Research Journal 4, no. 2 (2022): 85–93. http://dx.doi.org/10.54476/s051818.

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Creating a positive psychosocial learning environment (PsLE) that holistically considers the learners’ needs is vital to optimizing learning productivity in Science. This study investigates the Science learning environment as perceived by the students in actual Science classes. Anchored on the three PsLE dimensions namely: relationship, personal development, and systems maintenance and change, it tracks for alignment of the current Science teaching and learning practices to the expectations of the Kto12 Science curriculum standards. A survey method was done to gather the students’ perception r

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Lim, Lily Siok Hoon, Arlette Lefebvre, Susanne Benseler, and Earl D. Silverman. "Longterm Outcomes and Damage Accrual in Patients with Childhood Systemic Lupus Erythematosus with Psychosis and Severe Cognitive Dysfunction." Journal of Rheumatology 40, no. 4 (2013): 513–19. http://dx.doi.org/10.3899/jrheum.121096.

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Objective.(1) To describe the clinical course and response to treatment; and (2) to evaluate and compare damage accrual of distinct phenotypic subgroups of patients with clinically important psychiatric illness of pediatric systemic lupus erythematosus (pSLE).Methods.A single-center cohort study of patients with pSLE followed at a pediatric lupus clinic from 1985 to July 2009. Clinical course and response to treatment were studied. Remission was defined by absence of psychiatric/cognitive symptoms while receiving minimal doses of prednisone. Disease activity and damage were measured using SLE

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Balevic, Stephen J., Rachel Randell, Daniel Weiner, et al. "Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial." Lupus Science & Medicine 9, no. 1 (2022): e000811. http://dx.doi.org/10.1136/lupus-2022-000811.

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ObjectiveDetermine the pharmacokinetics (PK) and exposure–response of hydroxychloroquine (HCQ) and desethylhydroxychloroquine (DHCQ) in paediatric SLE (pSLE).MethodsWe conducted an exploratory phase 2, direct-to-family trial. Children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry with a diagnosis of pSLE were eligible if they were receiving HCQ as standard of care for ≥3 months. Biological samples were collected at up to four visits over a 6-month period. At each visit, plasma was obtained to measure the concentrations of HCQ and DHCQ, as well as cytok

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Felix, A., F. Delion, E. Coignard, et al. "POS1295 SYSTEMIC AND AUTO-INFLAMMATORY DISEASES OF PEDIATRIC ONSET: THE EXPERIENCE OF THE FRENCH OVERSEAS DEPARTMENTS OF AMERICA." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 984.2–985. http://dx.doi.org/10.1136/annrheumdis-2022-eular.431.

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BackgroundSystemic diseases of pediatric onset are more frequent in Afro-Caribbean population, especially Pediatric systemic lupus (pSLE).ObjectivesOur work is a retrospective study of patients followed in French overseas departments of America for systemic disease or auto-inflammatory syndrome of pediatric onset. It describes their clinical and biological specificities at diagnosis, during childhood and early adulthood.MethodsOur retrospective study was conducted between 01/01/2000 and 01/09/2021. Listings of adult patients with pediatric onset and pediatric patients were obtained in each cen

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Wulandari, Desy, Wisnu Barlianto, Susanto Nugroho, and Tita Sari. "Increase in Serum Ferritin Level as a Marker of Disease Activity in Pediatric Sys-temic Lupus Erythematosus (pSLE) Patients." Journal of Tropical Life Science 13, no. 2 (2023): 335–40. http://dx.doi.org/10.11594/jtls.13.02.11.

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Ferritin is an acute-phase reactant that is elevated in autoimmune disorders, including systemic lupus erythematosus (SLE). However, their correlation with disease activity scores has not been confirmed. Pandemic Covid-19 makes children visitation to hospital to get the treatment of SLE were delayed. This study aimed to evaluate correlation between serum ferritin and disease activity and its role in screening for flare in pediatric SLE (pSLE) patients during pandemic Covid-19. This is a cross-sectional study conducted in Saiful Anwar General Hospital Malang. Sampling was carried out sequential

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Kocheril, Anu Punnen, George Ipe Vettiyil, Anish Sam George, et al. "Pediatric systemic lupus erythematosus with lupus anticoagulant hypoprothrombinemia syndrome—A case series with review of literature." Lupus 30, no. 4 (2021): 641–48. http://dx.doi.org/10.1177/0961203321988934.

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Introduction Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare phenomenon that leads to concomitant thrombosis and hemorrhage in children with SLE. LAHPS in pediatric SLE (pSLE) has a protracted course requiring long-term immunosuppressive therapy. Due to the rarity of this syndrome and paucity of reported cases, there is lack of standardized management. We herewith report 5 children with pSLE with LAHPS. Methodology: We retrospectively reviewed clinical features, laboratory features, treatment and outcome for 5 children with lupus anticoagulant hypoprothrombinemia syndrome wi

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Lemrabet, Sanae, Maria El Qazoui, Lalla Meryem Idrissi Azzouzi, et al. "Evaluation of the Acute Flaccid Paralysis Virological Surveillance System in Polio-Free Morocco, 2010–2018." Advances in Public Health 2022 (September 23, 2022): 1–6. http://dx.doi.org/10.1155/2022/2729937.

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Background. The goal of Acute flaccid paralysis (AFP) surveillance is to comprehensively investigate and report any case of a child below 15 years with a floppy weakness. This is essential for the poliovirus eradication initiative. Objective. In this study, we analyzed the results of nine-year surveillance (2010–2018) of AFP in Morocco. Method. This was a descriptive, retrospective study of cases with AFP routinely documented at the National Referral Laboratory of Polio (NRLP) from 2010 to 2018. Results. Among the 884 AFP cases identified and analyzed, we identified 11 polioviruses as Sabin-li

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Schiel, Ralf, Rolf Bambauer, Reinhard Latza, and Jens Klinkmann. "Cyclosporin and plasmapheresis in treatment of progressive systemic lupus erythematosus (pSLE)." Transfusion Science 18, no. 1 (1997): 91–97. http://dx.doi.org/10.1016/s0955-3886(96)00082-3.

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Watkins, Peyton, Aneesha Achar, Julie Cherian, and Farzana Nuruzzaman. "LONG-TERM OUTCOMES OF PATIENTS WITH PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS (PSLE) TREATED WITH COMBINATION RITUXIMAB AND CYCLOPHOSPHAMIDE: A SINGLE-CENTER COHORT AND REVIEW OF LITERATURE." Journal of Rheumatology 52, Suppl 1 (2025): 173–74. https://doi.org/10.3899/jrheum.2025-0390.pv157.

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PV157 / #280Poster Topic:AS18 - Pediatric SLEBackground/PurposePatients with pSLE with life/organ-threatening manifestations are treated with a protocol of rituximab and cyclophosphamide at our institution as previously described.[1] However, the few published reports of the systematic administration of rituximab and cyclophosphamide in pSLE lacked representation of Black patients and/or evaluation of long-term damage indices beyond 1-2 years. We aimed to evaluate long-term Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores, exposure to steroids, and Systemic Lupus Internation

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Sharma, Sandeep, Anant K. Rathi, Kamal K. Verma, and Divya Bishnoi. "Comparison of stressful life events among family caregivers of cancer, mental retardation and schizophrenia patients leading to stress, anxiety and depression and its effect on quality of life." International Journal of Research in Medical Sciences 8, no. 6 (2020): 2140. http://dx.doi.org/10.18203/2320-6012.ijrms20202257.

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Background: Mental retardation (MR), schizophrenia and cancer are chronic disorders, requiring long term treatment along with family support. Principal caregiver is usually nonprofessional family person who play a pivotal role in supporting the patient medically, emotionally and financially which in turn affects their own health and quality of life. To identify stressful life events, level of anxiety, stress, depression and Quality of life in these family caregivers (FC), this study was planned.Methods: After gaining consent, the FC were assessed on Presumptive Stressful Life Events Scale (PSL

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Meyer, J. U., P. M. Burkhard, T. W. Secomb, and M. Intaglietta. "The Prony spectral line estimation (PSLE) method for the analysis of vascular oscillations." IEEE Transactions on Biomedical Engineering 36, no. 9 (1989): 968–71. http://dx.doi.org/10.1109/10.35306.

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Pang, Qiming, Bangtao Li, Bo Ding, Shuo Gu, Jiaoyang Li, and Suli Zhang. "A clinical study of mycophenolate mofetil combined with low-dose steroids in the management of pediatric systemic lupus erythematosus." Tropical Journal of Pharmaceutical Research 21, no. 6 (2022): 1287–94. http://dx.doi.org/10.4314/tjpr.v21i6.22.

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Purpose: To investigate the efficacy and safety of mycophenolate mofetil (MMF) combined with lowdose steroids in the treatment of pediatric systemic lupus erythematosus (pSLE).Methods: A total of 76 children were diagnosed and admitted with SLE, lupus nephritis (LN) and type IV diffuse proliferative glomerulonephritis at Hainan Women and Children’s Medical Center, Haikou, China from March 2017 to December 2018, had their clinical data analyzed retrospectively. Among them, 38 children received methylprednisolone pulse combined with MMF and intermittent oral low-dose glucocorticoids (GC), labell

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Swati, Singh, and Chauhan Shweta. "Caregiver Chronicles: Evaluation of Stress and Psychiatric Morbidity in Primary Caregivers for Alzheimer's- Type Dementia and Its Relationship to Their Personality Traits and Sociodemographic Characteristics." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 279–88. https://doi.org/10.5281/zenodo.12725558.

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<strong>Background:</strong> The main causes of caregiver stress and psychiatric morbidity were the patient’s behavioral and cognitive status, the number of hours spent providing care, stress, social isolation, gender, the caregiver’s relationship to the patient and their personality, and the accessibility of support resources. The impact of caregiving on the family must be quantified. Quantification and identification are critical for developing effective ways to alleviate caregiver pain. <strong>Objectives:</strong> The goals of this study were to assess stress and

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Breit, G. A., and M. Intaglietta. "A modeling cross-spectral analysis technique based on the Prony Spectral Line Estimator (PSLE)." IEEE Transactions on Biomedical Engineering 41, no. 3 (1994): 295–98. http://dx.doi.org/10.1109/10.284951.

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Kapoor, Teja, Pooja Mahadeshwar, Joyce Hui-Yuen, et al. "Prevalence of progressive multifocal leukoencephalopathy (PML) in adults and children with systemic lupus erythematosus." Lupus Science & Medicine 7, no. 1 (2020): e000388. http://dx.doi.org/10.1136/lupus-2020-000388.

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ObjectiveTo define the risk of progressive multifocal leukoencephalopathy (PML) in SLE.MethodsThis is a retrospective observational study to evaluate PML cases in patients with SLE admitted to two large academic hospitals. Using electronic medical record (EMR) data, International Classification of Diseases (ICD) codes identified PML cases among patients with SLE, rheumatoid arthritis (RA) (controls), had renal transplant and with HIV. Medication exposure was reviewed.ResultsA total of 5409 Columbia University Medical Center (CUMC) patients and 2046 Northwell Health patients were identified usi

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Sayibu, Muhideen, Issah Iddrisu, Jamal Mohammed, Sulemana Iddrisu, Akintunde Yinka Tosin, and Ekene Francis Okagbue. "A pedagogical smart learning environment (PSLE): mobile transitioning at home a constructivism theory in Ghana." International Journal of Smart Technology and Learning 4, no. 2 (2024): 168–89. https://doi.org/10.1504/ijsmarttl.2024.144487.

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Khosravi, Bahman, Behnam Khosravi, and Oskouei Dalili. "On recognition by prime graph of the projective special linear group over GF(3)." Publications de l'Institut Math?matique (Belgrade) 95, no. 109 (2014): 255–66. http://dx.doi.org/10.2298/pim1409255k.

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Let G be a finite group. The prime graph of G is denoted by ?(G). We prove that the simple group PSLn(3), where n ? 9, is quasirecognizable by prime graph; i.e., if G is a finite group such that ?(G) = ?(PSLn(3)), then G has a unique nonabelian composition factor isomorphic to PSLn(3). Darafsheh proved in 2010 that if p > 3 is a prime number, then the projective special linear group PSLp(3) is at most 2-recognizable by spectrum. As a consequence of our result we prove that if n ? 9, then PSLn(3) is at most 2-recognizable by spectrum.

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Benelmouffok, O. Gacem, Djohra Hadef, and Mohamed Sam Ladj. "Cutaneous manifestations of pediatric systemic lupus erythematosus." Journal of Dermatology & Cosmetology 7, no. 1 (2023): 28–31. http://dx.doi.org/10.15406/jdc.2023.07.00228.

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Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease that affects both adults and children, but with different degrees of severity. Indeed, pediatric Systemic Lupus Erythematosus (pSLE) is more serious than that of adults and the management is heavier with significant comorbidity. The clinical manifestations are polymorphic. The skin is one of the target organs most diversely affected by the disease. Indeed the cutaneous manifestations are frequent, they are almost constant during the evolution reflecting the activity of the disease. Long considered relatively benign

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Porbaran, Mahyar, та Reza Habibipour. "Relationship between Biofilm Regulating Operons and Various Β-Lactamase Enzymes: Analysis of the Clinical Features of Infections caused by Non-Fermentative Gram-Negative Bacilli (Nfgnb) from Iran". Journal of Pure and Applied Microbiology 14, № 3 (2020): 1723–36. http://dx.doi.org/10.22207/jpam.14.3.11.

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Bacteria are capable of evolving high doses of the drug in various infections by forming biofilms. Perhaps, biofilm regulator genes have different frequencies in β-lactam producing non-fermentative Gram-negative Bacilli (NFGNB). In this study, we investigated the role of biofilm operons of Pseudomonas aeruginosa and Acinetobacter baumannii on the prevalence of different β-lactamase enzymes. One-hundred twenty (120) nosocomial NFGNB isolates were collected from different clinical samples of patients. PCR method was used for the amplification of resistance genes. Isolates were collected, includi

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Kabir, Rubaiya Binte, Tasnim Ahsan, Md Faizur Rahman, Mohammad Jobayer, and SM Shamsuzzaman. "Biofilm-Producing and Specific Antibiotic Resistance Genes in Pseudomonas aeruginosa Isolated from Patients Admitted to a Tertiary Care Hospital, Bangladesh." Bangladesh Journal of Microbiology 40, no. 2 (2024): 60–65. http://dx.doi.org/10.3329/bjm.v40i2.73788.

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Pseudomonas aeruginosa is one of the organisms well-known for producing biofilm. Biofilms are responsible for persistent infections and antimicrobial resistance. The aim of this was to investigate P. aeruginosa for its ability to form biofilm. Genes that were responsible for the production of biofilms and biofilm-specific antimicrobial resistance were detected. The association between antibiotic resistance and biofilm was investigated. This cross-sectional study was conducted from July 2017 to December 2018. A total of 446 samples (infected burns, surgical wounds, and ETA) were collected from

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Kadhum, Mohammed Abed Jawad, Izzat Abdul Satar Al-rayahi, and Usama Slaman Abd-Razzaq Altimari. "Serum Level Determination of Some Immunological Parameters and STAT Genes in Pediatrics SLE Patients Compared to Healthy Control." NeuroQuantology 19, no. 6 (2021): 20–24. http://dx.doi.org/10.14704/nq.2021.19.6.nq21062.

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Systemic lupus erythematosus was defined as an autoimmune chronic systemic rheumatic disease. it has many disease phenotypes and clinical symptoms varying from one patient to another, which include mild mucocutaneous manifestations to severe involvement of the central nervous system and various organs in the body. Several pathogenic pathways of immunity play a part in the progression of SLE. The aims of this study are to determine the serum levels of C3, C4, IL-9, IL-10, IL-12 and INF-gamma and disease activity in pediatric Iraqi (pSLE) patients additionally in this study we aim to find the le

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Thapa, R. "Dissociative disorders: A study of clinico-demographic profile and associated stressors." Journal of Psychiatrists' Association of Nepal 3, no. 2 (2015): 25–30. http://dx.doi.org/10.3126/jpan.v3i2.12386.

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Objectives: To study relevant clinico-demographic profile and stressors of dissociative disorders. Methods: this is a case control study of 39 cases of dissociative disorders and compared with 39 controls using a self designed questionnaire and G. Singh’s Presumptive Stressful Life Events Scale (PSLE). Results: The mean age of the cases was 21.23 years. Cases of Dissociative motor disorders had significantly higher age (26.4 yrs) as compared to dissociative convulsion (18.8 yrs) and dissociative stupor (20.6 yrs). (38.5%).Two thirds of the cases had comorbid neuro-psychiatric illness, the comm

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Chen, P. P., F. Gõni, R. A. Houghten, et al. "Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides." Journal of Experimental Medicine 162, no. 2 (1985): 487–500. http://dx.doi.org/10.1084/jem.162.2.487.

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Recently, we have used synthetic peptides corresponding to the complementarity-determining regions (CDR) of Ig molecules to induce antiidiotypic antisera. Peptide PSH3, representing the third CDR of the IgM rheumatoid factor (RF) Sie heavy (H) chain, induced a private antiidiotype that reacted with only one out of five IgM-RF. Peptide PSL2, corresponding to the second CDR of Sie light (L) chain, induced an antibody against a crossreactive idiotype (CRI), expressed by 10 out of 12 human IgM-RF analyzed. Herein, we report that five additional antiidiotypic antibodies were generated by immunizati

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Goñi, F. R., P. P. Chen, D. McGinnis, et al. "Structural and idiotypic characterization of the L chains of human IgM autoantibodies with different specificities." Journal of Immunology 142, no. 9 (1989): 3158–63. http://dx.doi.org/10.4049/jimmunol.142.9.3158.

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Abstract We have determined the V region amino acid sequence and/or serologic markers (kIIIb, PSL2, and PSL3) of 24 IgM monoclonal autoantibodies with specificities of anti-gamma-globulin (RF), anti-I (cold agglutinin), anti-low density lipoprotein and anti-intermediate filaments. The data emphasize the overwhelming selection of the HumKv325/VkIIIb L chain for this family of autoantibodies. The few amino acid substitutions found within the VL regions were mainly concentrated in the complementarity-determining region 1. JK and CK genes did not show the same pattern of restriction. There is a go

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Overhage, Jörg, Mirle Schemionek, Jeremy S. Webb, and Bernd H. A. Rehm. "Expression of the psl Operon in Pseudomonas aeruginosa PAO1 Biofilms: PslA Performs an Essential Function in Biofilm Formation." Applied and Environmental Microbiology 71, no. 8 (2005): 4407–13. http://dx.doi.org/10.1128/aem.71.8.4407-4413.2005.

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ABSTRACT The psl gene cluster, comprising 15 cotranscribed genes from Pseudomonas aeruginosa, was recently identified as being involved in exopolysaccharide biosynthesis and biofilm formation. In this study, we investigated the regulation of the psl gene cluster and the function of the first gene in this cluster, the pslA gene. PslA shows strong similarities to UDP-glucose lipid carriers. An isogenic marker-free pslA deletion mutant of P. aeruginosa PAO1 deficient in attachment and biofilm formation was used for complementation studies. The expression of only the pslA gene, comprising a coding

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Chen, P. P., D. L. Robbins, F. R. Jirik, T. J. Kipps, and D. A. Carson. "Isolation and characterization of a light chain variable region gene for human rheumatoid factors." Journal of Experimental Medicine 166, no. 6 (1987): 1900–1905. http://dx.doi.org/10.1084/jem.166.6.1900.

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Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.

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