Dissertations / Theses on the topic 'PSP-P'

Die Progressive Supranukleäre Blickparese (PSP) ist eine sporadisch auftretende neurodegenerative Erkrankung im Rahmen der atypischen Parkinson-Syndrome (APS), die im frühen Verlauf häufig mit dem Idiopathischen Parkinson-Syndrom (IPS) verwechselt wird. Dabei ist die Dysarthrie als eine erworbene, zentral bedingte sprechmotorische Störung ein häufiges und früh auftretendes Symptom bei PSP. Bislang spricht man von einer eher unspezifischen „gemischten“ Dysarthrie aus hypokinetischen, spastischen und auch ataktischen Komponenten. Im Rahmen einer explorativen Querschnittsstudie am „Fachkrankenhaus für Bewegungsstörungen und Parkinson“ Beelitz-Heilstätten in Kooperation mit der „Entwicklungsgruppe Klinische Neuropsychologie“ München (EKN) sowie der „Interdisziplinären Ambulanz für Bewegungsstörungen“ am Klinikum München-Großhadern wurden 50 Patienten dahingehend untersucht, ob sich für die Progressive Supranukleäre Blickparese (PSP) eine spezielle, frühzeitig zu diagnostizierende und differentialdiagnostisch relevante Dysarthrie beschreiben ließe. In diesem Zusammenhang soll geklärt werden, ob es sich um phänotypische Ausprägungen im Rahmen eines Störungsspektrums handelt oder ob sich differenzierbare Subtypen der Krankheit, insbesondere ein „klassischer“ PSP-Typ (PSP-RS) und ein „atypischer“ PSP-Typ (PSP-P), auch im Bereich der Dysarthrie zeigen. Im Rahmen der Untersuchungen wurde der Schweregrad der Erkrankung mittels der „PSP-sensitiven Ratingskala (PSPRS)“ gemessen. Die Dysarthriediagnostik erfolgte anhand der „Bogenhausener Dysarthrieskalen (BoDyS)“ zur Beschreibung der Art und Ausprägung der Dysarthrie bei PSP. Die Verständlichkeit wurde mithilfe des „Münchner Verständlichkeits-Profils (MVP)" sowie eines weiteren Transkriptionsverfahrens ermittelt, wobei Ausschnitte aus den Tests zum Lesen und Nachsprechen der BoDyS zugrunde lagen. Weiterhin erfolgte eine Einschätzung der Natürlichkeit des Sprechens. Die Ergebnisse hinsichtlich des Einflusses von Natürlichkeit und Verständlichkeit des Sprechens auf den Schweregrad der Dysarthrie zeigten, dass dieser modalitätenübergreifend mit beiden Schweregradaspekten korreliert, wenngleich es offenbar die Natürlichkeit des Sprechens ist, die bei PSP bereits frühzeitig beeinträchtigt ist und somit als das entscheidende differentialdiagnostische Kriterium zur Differenzierung zwischen beiden PSP-Subtypen zu beurteilen ist, möglicherweise auch gegenüber anderen Parkinson-Syndromen. Anhand statistisch valider Ergebnisse konnten spezifische Störungsmerkmale der Dysarthrie extrahiert werden, die eine signifikante Trennung von PSP-RS und PSP-P ermöglichen: eine leise und behaucht-heisere Stimme sowie ein verlangsamtes Sprechtempo und Hypernasalität. Damit können für die hier fokussierten Subtypen der PSP zwei unterschiedliche Dysarthrietypen postuliert werden. Danach wird dem Subtyp PSP-RS eine spastisch betonte Dysarthrie mit ausgeprägter Verlangsamung des Sprechtempos zugeordnet, dem Subtyp PSP-P hingegen eine hypokinetische Dysarthrie mit behaucht-heiserer Hypophonie. Desweiteren konnte ein „Dysarthrie-Schwellenwert“ als Zusatzkriterium für eine zeitliche Differenzierung beider PSP-Subtypen ermittelt werden. Anhand der Daten zeigte sich die Dysarthrie bei dem Subtyp PSP-RS gleich zu Beginn der Erkrankung, jedoch spätestens 24 Monate danach. Hingegen konnte die Dysarthrie beim Subtyp PSP-P frühestens 24 Monate nach Erkrankungsbeginn festgestellt werden. Die Daten dieser Studie verdeutlichen, dass der Frage nach einer subtypenspezifischen Ausprägung der Dysarthrie bei PSP eine Längsschnittsstudie folgen sollte, um die ermittelten Ergebnisse zu konsolidieren.<br>Progressive Supranuclear Palsy (PSP) is an atypical Parkinsonian syndrome characterized by gait ataxia, slowing or inability to generate vertical saccadic eye movements, axial rigidity, cognitive disorders and a progressive dysarthria. The dysarthria may include abnormalities in strength, speed, range, tone or accuracy of speech movements. As the disease progresses, important functional components of speech including respiration, phonation, resonance, articulation and prosody are affected. The question is what kind of dysarthria do we find in PSP? Until now it remains unclear, if the dysarthric characteristics of PSP vary in way as described by Williams et al. (2005) who found clinically distinct symptom patterns of a Parkinsonian form of PSP (PSP-P) distinct from a classical form (Richardson Syndrome). The aim of the cross-sectional multi center study was to investigate the specific dysarthric symptoms in patients with PSP. Until now it remains unclear, whether there are two different points on a continuous spectrum of speech disturbances or if there exist distinct „profiles“ of dysarthria according to the proposed Richardson Syndrome (PSP-RS) with early onset of postural instability and falls, vertical gaze palsy and cognitive dysfunctions and the PSP with Parkinsonism (PSP-P) with asymmetric onset, tremor, early bradykinesia, non-axial dystonia and response to levodopa medications in the beginning. „Bogenhausener Dysarthrieskalen“ (BoDys) was used as base-line dysarthria scale: pitch pattern, loudness range, voice quality, respiration and resonance capacities, prosody and articulation were rated. Furthermore, the intelligibility is a most important index of functional impairment in dysarthria. Therefore, the „Munich Intelligibility Profile (MVP)“, a computer-based method for the assessment of the intelligibility of dysarthric patients, was used to describe the intelligibility of the patients. The PSP-P-group, at the beginning frequently confused with patients with PD, showed rigide-hypokinetic dysarthric features with hypophonia as cardinal symptom. In contrast the patients with the “classical” PSP-RS-Type show severe speech impairments in terms of a very effortful speak with a progressive loss of intelligibility. They show spastic components of dysarthria, like a very strained-strangled voice with breaks and voice stoppages, harshness and reduced pitch and loudness variability. Their loudness often is inadequate in terms of the so called “lions voice”. Further they show a hypernasality, the articulation is imprecise, the vowels are distorted. Concerning the prosody there is a very slow and strained rate of speech with equal or excess stress. The results show that the patients with PSP-RS generally suffer from severe and more progressive speech impairments beginning early after disease onset, whereas the PSP-P-group shows rather moderate symptoms. The dysarthria in PSP is subtype-specific. The hypothesis of different dysarthric profiles for the proposed clinical subtypes "Richardson Syndrome" (PSP-RS) and "PSP with parkinsonism" (PSP-P) was confirmed and based on a discriminant analysis that identified distinctive dysarthric features for both subgroups.

La caracterisation de l'anisotropie sismique offre la possibilite de comprendre le role joue par les fractures et les fluides dans les processus tectoniques, de controler les caracteristiques des reservoirs geothermiques ou d'hydrocarbures, ou de detailler la structure de la croute terrestre. La presence d'anisotropie peut etre mise en evidence par l'etude des variations angulaires de la vitesse des ondes p, ou par l'analyse de la birefringence des ondes s. Une technique d'inversion des temps de trajet est developpee afin d'obtenir l'information vehiculee par les ondes p. La propagation de ces ondes en milieu transverse isotrope est calculee par la theorie des rais associee a des methodes perturbatives. Le probleme inverse est ensuite resolu par decomposition en valeurs singulieres. Les tests de sensibilite des temps aux parametres inverses, ont montre la necessite d'introduire de l'information a priori dans l'inversion. De meme, des exemples synthetiques ont souligne l'importance de disposer d'une bonne couverture angulaire et azimutale de la structure etudiee. L'application de cette methode tomographique a des donnees de puits du bassin parisien, a permis de detecter la presence d'anisotropie dans le cretace (argiles et sables), ainsi que dans les niveaux reservoirs. L'origine de l'anisotropie est attribuee a l'existence de micro-fractures verticales orientees dans la direction du champ de contrainte regional. La birefringence des ondes s est etudiee sur le site de soultz-sous-forets, avant et pendant des injections d'eau en puits profond, dans le but d'identifier les zones de flux dans les systemes de fractures naturelles. Avant injection, le socle granitique apparait homogene et isotrope, et la presence de failles majeures a ete detectee ; de l'anisotropie est par ailleurs observee dans les sediments superficiels. Au cours de l'injection, les proprietes isotropes du massif ne sont pas affectees. Cependant, des modifications des temps de trajet semblent indiquer l'accentuation d'une structure heterogene, liee a la percolation du fluide injecte

Neste trabalho obteve-se, com o experimento STAR, medidas de produção de J/&psi; e &upsih; em rapidez central (&eta;=0), em colisões p+p com &radic;s = 200 GeV no RHIC. A medida de &upsih; foi a primeira medida de bottomonium em rapidez central no RHIC. Essas medidas servem como linha de base para a investigação experimental sistemática da supressão de heavy-quarkonium, tida como uma evidência observacional do Plasma de Quarks e Glúons (QGP). Para a realização dessas medidas foi desenvolvido um sistema específico de gatilho de eventos para heavy-quarkonium, envolvendo, em sua configuração, os subsistemas do calorímetro eletromagnético (BEMC) e do cilindro de gatilho central (CTB, apenas para J/&psi;). Os resultados obtidos foram a seção de choque de produção de J/&psi;, BRee&times;&sigma;J/&psi;incl = 122(23)estat(27)sist. (nb), e de &upsih;, BRee&times;d&sigma;&upsih;/dy|y=0 = 114 (29)estat(24)sist. (pb), além do espectro em momento transversal de J/&psi;, cujo momento quadrático médio observado foi &lsaquo; pT2&rsaquo;=3,43(68) (GeV/c)2. Os resultados obtidos foram comparados com previões teóricas de 3 modelos, o de singleto de cor (CSM), QCD não-relativística (NRQCD) e de evaporação de cor (CEM), além de diversos outros dados experimentais. Com excessão do CSM, todos os modelos concordam razoavelmente bem com os dados experimentais.<br>This work presents mid-rapidity (&eta;=0) J/&psi; and &upsih; measurements for p+p collisions at &radic;s = 200 GeV from the STAR experiment at RHIC. &upsih; results correspond to the first mid-rapidity bottomonium measurement at RHIC. These measurements can be used as the baseline of the systematic experimental investigation on heavy-quarkonium suppression, believed to be one important observational evidence of the existence of the Quark-Gluon Plasma (QGP). In order to acquire the data for these analyses, it was necessary to develop a new heavy-quarkonium trigger system, based on the Barrel Electromagnetic Calorimeter (BEMC) and the Central Trigger Barrel (CTB, J/&psi; only) detectors. The inclusive J/&psi; cross section at mid-rapidity is BRee&times;&sigma;J/&psi;incl = 122(23)estat(27)sist. (nb) and for the &upsih;, BRee&times;d&sigma;&upsih;/dy|y=0 = 114 (29)estat(24)sist.(pb). In the case of the J/&psi; measurement, we acquired enough statistics to obtain a transverse momentum spectrum and the mean squared transverse momentum is &lsaquo; pT2&rsaquo;=3,43(68) (GeV/c)2. These results were compared to theoretical predictions of 3 different models, the Color Singlet Model (CSM), the Non-Relativistic QCD (NRQCD) and the Color Evaporation Model (CEM), as well as to other experimental data. Except for the CSM, all the predictions agree reasonably well with the data.

La teoria dell’interazione forte, la Cromodinamica Quantistica, non è tuttora risolvibile completamente. Le sue proprietà emergenti in sistemi interagenti sono dunque il soggetto della maggior parte degli studi nella fisica degli ioni pesanti. Le collisioni protone-protone possono fornire un punto di vista alternativo su questo argomento, con differenti limitazioni ma anche dfferenti possibilità. Questa tesi si propone di investigare su possibili indizi di fenomeni collettivi, come la formazione di plasma di quark e gluoni, in collisioni protone-protone. Per questo scopo, è stato effettuato uno studio sulla dipendenza dalla molteplicità delle produzioni di J/ψ and ψ(2S) e dei loro rapporti, all’energia di √s = 7 TeV nell’ambito dell’esperimento CMS al Large Hadron Collider. I risultati sono stati poi discussi e messi in relazione con altri recenti dati sperimentali. La tesi è organizzata nel seguente modo: • nel Capitolo 1 vengono presentate un’introduzione alla teoria della Cromodinamica Quantistica e una panoramica sulla fenomenologia del plasma di quark e gluoni; • nel Capitolo 2 vengono introdotte le principali caratteristiche dell’esperimento CMS al Large Hadron Collider; • nel Capitolo 3 viene descritta la valutazione dei valori di produzione di J/ψ and ψ(2S), e successivamente la separazione delle loro frazioni dirette e indirette; • nel Capitolo 4 viene discusso il calcolo della molteplicità di tracce cariche, ovvero il numero di particelle cariche primarie prodotte nella collisione, che deve essere associato ad ogni coppia di muoni; • nel Capitolo 5 si studia l’andamento in funzione della molteplicità carica dei valori di produzione di J/ψ and ψ(2S) e dei loro rapporti. Inoltre si studia l’andamento, sempre in funzione della moltpelicità carica, dell’impulso trasverso medio di J/ψ and ψ(2S); • nel Capitolo 6 i risultati sono discussi e confrontati con altri recenti studi sperimentali.

In questo lavoro di tesi è stato studiato lo spettro di massa invariante del sistema J/psi pi+ pi-, m(J/psi pi+ pi-), in collisioni protone-protone a LHC, con energia nel centro di massa sqrt(s)) pari a 8 TeV, alla ricerca di nuovi stati adronici. Lo studio è stato effettuato su un campione di dati raccolti da CMS in tutto il 2012, corrispondente ad una luminosità integrata di 18.6 fb-1. Lo spettro di massa invariante m(J/psi pi+ pi-), è stato ricostruito selezionando gli eventi J/psi->mu+ mu- associati a due tracce cariche di segno opposto, assunte essere pioni, provenienti da uno stesso vertice di interazione. Nonostante l'alta statistica a disposizione e l'ampia regione di massa invariante tra 3.6 e 6.0 GeV/c^2 osservata, sono state individuate solo risonanze già note: la risonanza psi(2S) del charmonio, lo stato X(3872) ed una struttura più complessa nella regione attorno a 5 GeV/c^2, che è caratteristica della massa dei mesoni contenenti il quark beauty (mesoni B). Al fine di identificare la natura di tale struttura, è stato necessario ottenere un campione di eventi arricchito in adroni B. È stata effettuata una selezione basata sull'elevata lunghezza di decadimento, che riflette la caratteristica degli adroni B di avere una vita media relativamente lunga (ordine dei picosecondi) rispetto ad altri adroni. Dal campione così ripulito, è stato possibile distinguere tre sottostrutture nello spettro di massa invariante in esame: una a 5.36 GeV/c^2, identificata come i decadimenti B^0_s-> J/psi pi+ pi-, un'altra a 5.28 GeV/c^2 come i candidati B^0-> J/psi pi+ pi- e un'ultima allargata tra 5.1 e 5.2 GeV/c^2 data da effetti di riflessione degli scambi tra pioni e kaoni. Quest'ultima struttura è stata identificata come totalmente costituita di una combinazione di eventi B^0-> J/psi K+ pi- e B^0_s-> J/psi K+ K-.

Thesis (Ph. D.) -- University of Maryland, College Park, 2008.<br>Thesis research directed by: Dept. of Mathematics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

L'experience na38 etudie la production de dimuons dans des collisions induites par des ions lourds a 200 gev par nucleon. Quand la densite d'energie augmente, une suppression de la production du meson j/psi par rapport aux paires de muons dans le continuum a ete observee. Cet effet est attendu en cas de formation d'un plasma de quarks et de gluons, etat de la matiere nucleaire predit par la chromodynamique quantique. La principale difficulte de cette analyse reside dans l'evaluation de l'important bruit de fond genere par les desintegrations de pions et de kaons. Le present travail reprend l'analyse de l'ensemble des donnees de l'experience, sur la base d'une methode statistique d'estimation du bruit de fond. Cette methode, qui s'appuie sur l'information tiree des muons simples deduits des paires de muons mesurees dans l'appareillage, permet une amelioration sensible de la precision sur le signal. Cette analyse montre que la suppression relative du j/spi par rapport au continuum est plus importante dans les reactions noyau-noyau que dans les reactions proton-noyau. De plus, elle montre que la production de dimuons dans le continuum depend de l'isospin du projectile, ce qui rend delicate la comparaison aux collisions induites par des protons. Efin l'etude de la production du j/psi en fonction de la densite d'energie ne permet pas de favoriser une interpretation de la suppression en termes de plasma plutot qu'en termes d'absorption dans le gaz de mesons, bien que la valeur absolue de l'effet ne soit pas totalement comprise

The purpose of this study was to determine the relationships between the scores of students on the Pre-Professional Skills Test (P-PST) and the scores of students on college aptitude tests, the race of students and the number of college hours that students had completed. The subjects who participated in this study were education students who sought admittance to Texas public colleges and universities and took the P-PST in March, 1984. A total of 642 students participated in the study, 512 White or other, 48 Blacks and 82 Hispanics. P-PST scores, race, number of college hours completed, and college aptitude scores were obtained from the student's college or university as a result of the signed release forms each student completed at the March, 1984 testing date.

The search for more effective treatment strategies in melanoma led to many new innovative approaches aiming at different molecular targets. Chemotherapy still remains the most effective treatment and many efforts are put in order to improve targeting and delivery of the chemotherapeutic agents. Among these, peptide conjugates of anticancer drugs were designed to increase stability, cell penetration, specificity and accumulation in cancer cells. We as well as others evaluated such a conjugate, termed PSF (L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine-ethylester) in terms of its cytotoxicity in vitro and in vivo using a human melanoma tumor as a model, its stability, transport, and metabolisation. <p>By comparing the cytotoxicity of PSF and melphalan towards different cancer primary melanoma cell cultures, we noticed some interesting observations: PSF displayed the same toxicity pattern both in short (2h) and long term (24h) cell exposures whereas melphalan and m-sarcolysin needed long term exposure to reach the same toxicity. This could indicate that PSF very quickly penetrates the cells in accordance with what has been shown with red blood cells (RBCs). PSF has shown a much better and quicker penetration into the cells in vitro as compared to melphalan. <p>In this present work, the cytotoxic effect of PSF was further evaluated in vivo using a standardized nude mice tumor model bearing a human melanoma. First, the acute toxicity in rats and mice and the maximum tolerated dose were determined. After a dose-escalation study one dose was singled out and tested as a single dose and as a fractionated dose. PSF was able to reach the tumor site and a dose-response relationship was observed. The IP administration of fractionated doses of PSF had significantly better effect on tumor growth inhibition, regression and regrowth than single dose administration and this without any evidence for general toxicity monitored by animal weight loss. We also compared the efficacy of PSF to its parent drug m-sarcolysin, melphalan and cyclophosphamide and observed that PSF was much more active than both melphalan and m-sarcolysin at the same molar doses.<p>Body distribution of the 14C-labelled PSF revealed ratios of 2.4 and 1.5 compared to muscle tissue for the two melanoma tumors evaluated with no significant and stable accumulation in any vital organ. The amount of tracer was still high in the blood after 24 hours explaining the high radioactivity in the kidney and partly in the liver. Interestingly, the spleen had an unusual high radioactivity uptake reflecting the exceptional binding of the tracer to blood cells (BC), while the pancreas very high load was an indicator of protease-mediated specific delivery and strongly support our hypothesis elaborated on the basis of in vitro results. <p><p>Our in vitro data point to a particular mechanism of action of PSF based on the transport of PSF through the body by the rapid binding to blood cells and the delivery at the tumor site by the subsequent release of its active metabolites due to cleavage by tumor-associated proteases.<p>Concerning the binding of PSF to membranes and its transport the following observations were made: while PSF was stable in human plasma, it disappeared very quickly in whole blood along with the generation of a main metabolite: m-sarcolysin. The presence of BC membranes was required for both binding and generating the metabolites. Binding to natural or artificial membranes was achieved and only competition with melanoma cells or proteolytic enzymes such as dispase, led to the generation of active metabolites. The different metabolites were isolated using preparative LC and were then identified using Electrospray Ionisation Mass Spectrometry (ESI). Three metabolites, of which m-sarcolysin was the main one, were identified all bearing the chloroethyl alkylating group. <p>Enzymatic catalysis was further supported by a set of experiments where the enzymatic activity was non-specifically and specifically inhibited. In order to look at the effect of extracellular matrix proteases on PSF, three representatives of ECM proteases were incubated with PSF: collagenase A had no effect, but both dispase and trypsine were able to process PSF. <p>The following data indicate the higher processing of PSF in the presence of cells with a higher proteolytic activity and thus the delivery of the blood cell-bound PSF. When comparing BC with melanoma cells (MC), the latter showed a higher ability to bind and process PSF both by membrane-associated and most interestingly soluble proteases. A lot of families of enzymes are reported to be overexpressed by melanoma cells including: metalloproteases, cysteine cathepsins, serine proteases and aminopeptidases. All the melanoma cells and cell lines evaluated were able to generate PSF active metabolites. <p>To identify the families of enzymes expressed on the membrane of melanoma cells that might be involved in the mechanism of action of PSF, we performed 2D-gel electrophoresis on their membrane extracts. The 2D-gels experiments revealed the presence of proteins compatible with enzymes known to be important in melanoma and further work is needed to identify the individual enzymes involved by using mass spectrometry and Western blotting. <p><p>Both our in vitro and in vivo findings strongly suggest that not only melanoma tumor cells and tumor sites but other types of tumors as well may be targets for the toxic activity of PSF owing to their much higher load in proteolytic enzymes that are closely related to their invasive potential. The transport of PSF by the blood cells and the release of its metabolites at the tumor site result in a low amount of drug in its free soluble form within the blood and this may explain the relatively lower side-effects observed. PSF is thus expected to have a much better therapeutic index than conventional alkylating agents. This original mechanism of drug delivery may well be extended to other cancer and non-cancer drugs than alkylating agents.<p><br>Doctorat en Sciences biomédicales et pharmaceutiques<br>info:eu-repo/semantics/nonPublished

Social attitude is the approach of a person displayed towards other individuals or groups. Social attitude comprehensively affects the way we perceive, behave in, and interact with, the surrounding world; it is simply not possible to understand complex social behaviour such as strategic thinking without first knowing the attitude of the parties involved. Several disciplines contribute to the complex study of social attitude (social preferences in economics, social value orientation in psychology), but only recently have these disciplines started to communicate and develop comprehensive definitions and models. In particular, the current research debate focuses on pinpointing the nature of social attitude (e.g., what its defining components are), the factors that influence it (e.g. context, other individuals), as well as its consequences (e.g., its relevance for self-image representation). This thesis aims to answer to some of the open questions in the literature by testing and comparing the proposed competing explanations. The studies presented are based on a series of behavioural experiments coupled with established but also newly developed measurement tools concerning social norms and personal preferences. In addition, we try to uncover the mental processes underlying decisions with the help of computational models. The thesis is structured as follows. In Chapter 1, We outline a brief summary of the theories on social attitude from the economic and psychological literature, and describe the main tasks and models employed in the thesis. Chapter 2 explores how social attitude is influenced by others’ behaviour. We conduct a systematic comparison of the possible mechanisms driving attitude conformity using various experimental conditions, computational models, and control tasks (e.g., norm elicitation). We find that participants conform due to both peer influence (by learning from others about how salient a norm is) and compliance to authority (i.e. experimenter demand effects). Chapter 3 studies the effect of context in a task eliciting social attitude. We specifically test the effect of unavailable choices, that we call ”meta-context”, on participant’s decisions. We find that participants’ concerns about social norms, as well as their choices, depend on the currently available options, but also on meta-context. In Chapter 4, we study whether individuals tend to selectively forget about their morally questionable choices, and information related to it, such as the context in which the choice was made. We find that participants recollect less correctly selfish or anti-social choices compared to pro-social ones, but we find no memory bias concerning the context of the choice. Moreover, we uncover some potential evidence of a second memory bias related to choice frequency: people are generally more pro-social than antisocial, which means antisocial choices are more rare and thus more difficult to remember correctly. Finally, in chapter 5 We summarise the main findings of the thesis and present some conclusions. We try to integrate the various results to propose an empirically-informed model of social attitude to be applied in future research on the topic.

Made available in DSpace on 2015-04-14T13:46:27Z (GMT). No. of bitstreams: 1 398610.pdf: 1632690 bytes, checksum: bd1ef64068a74ac41d14e9695e8d1cc9 (MD5) Previous issue date: 2008-01-11<br>Este trabalho apresenta a trajet?ria do PSD ga?cho e a sua rela??o com o jornal Di?rio de Not?cias de 1945 a 1965. Por n?o seguir a orienta??o pol?tico-partid?ria, indicada pelo seu partido nos per?odos eleitorais, esse diret?rio regional foi considerado o mais dissidente do pa?s. Durante esse per?odo, o partido no Rio Grande do Sul foi cindindo lentamente, sofrendo em muitos momentos, a interfer?ncia do propriet?rio do Di?rio de Not?cias, Assis Chateaubriand. As linhas de reflex?o do jornal variaram conforme as mudan?as ocorridas na conjuntura pol?tica daquele per?odo, no entanto, encampou v?rias campanhas pol?ticas com vistas a atingir seus interesses. Portanto, buscou-se compreender o papel desempenhado por esse jornal na organiza??o e consolida??o do PSD ga?cho, desde o seu in?cio no fim do Estado Novo at? a sua desagrega??o na d?cada de 1960.

Les collisions d'ions lourds ultrarelativistes ont été proposées pour créer une phase exotique de la matière, appelée le plasma de quarks et de gluons. Une manifestation éventuelle de ce plasma est la suppression des états lies charmonium (c cbar). Pour l'observer, l'expérience na38 du CERN étudie les paires de muons produites lors d'interactions d'ions a 200 gev/nucléon, dans un domaine de masse comprise entre 0. 5 et 7. 0 gev/c2. La première partie de ce travail traite le problème des évènements avec interactions multiples, lie aux fortes intensités du faisceau. L’analyse présentée ensuite concerne la comparaison des productions des résonances psi et j/psi et du continuum de masse, dans les collisions proton-uranium et soufre-uranium. En particulier, le rapport bmumu sigma (psi)/bmumu sigma (j/psi) est étudié en fonction de la densité d'énergie du système, epsilon, et de l'épaisseur de matière nucléaire traversée part la paire c cbar; ce rapport est deux fois plus grand en proton-noyau qu'en s-u, et il diminue d'environ 40% avec epsilon pour le système s-u. Ce résultat est discuté dans le contexte du deconfinement (formation du plasma de quarks et de gluons) et dans le cadre de modèles d'absorption.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-01-03T19:53:02Z No. of bitstreams: 1 AmilkaDayaneDiasMelo_DISSERT.pdf: 8582091 bytes, checksum: a78ec666d0a3d06d1308e15e43ca615f (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-01-05T21:54:59Z (GMT) No. of bitstreams: 1 AmilkaDayaneDiasMelo_DISSERT.pdf: 8582091 bytes, checksum: a78ec666d0a3d06d1308e15e43ca615f (MD5)<br>Made available in DSpace on 2017-01-05T21:54:59Z (GMT). No. of bitstreams: 1 AmilkaDayaneDiasMelo_DISSERT.pdf: 8582091 bytes, checksum: a78ec666d0a3d06d1308e15e43ca615f (MD5) Previous issue date: 2016-02-26<br>O presente trabalho discute as repercuss?es do Piso Salarial Profissional Nacional (PSPN) no vencimento dos profissionais do magist?rio da rede p?blica estadual do Rio Grande do Norte (RN) no per?odo 2008 a 2014, por meio da implementa??o da Lei n? 11.738/2008, considerando o contradit?rio e as similaridades entre governo e Sindicato dos Trabalhadores em Educa??o do Estado do RN (Sinte/RN). Utilizou-se de pesquisa bibliogr?fica e documental, bem como de informa??es do Plano de Cargos Carreira e Remunera??o (PCCR) do magist?rio da rede estadual do RN, aprovado pela Lei Complementar n? 322/2006, folhas de pagamento do magist?rio (refer?ncia m?s de outubro) e seus resumos cedidos pela Secretaria de Administra??o e Recursos Humanos do RN (SEARH-RN). Os estudos te?ricos demonstram que, a partir da Constitui??o Federal de 1988, a pol?tica de valoriza??o do magist?rio vem sendo palco de debates na agenda da pol?tica educacional, determinando suas diretrizes e forma de financiamento, vias Fundos Cont?beis ? Fundo de Manuten??o e Desenvolvimento do Ensino Fundamental e de Valoriza??o do Magist?rio (Fundef) e Fundo de Manuten??o e Desenvolvimento da Educa??o B?sica e de Valoriza??o dos Profissionais da Educa??o (Fundeb) ?, resolu??es do Conselho Nacional de Educa??o e a Lei do Piso. Essas legisla??es visam garantir direitos assegurados, mediante forma??o, condi??es de trabalho, vencimento e remunera??o dos professores. A Lei n? 11.738/08 do PSPN determina o valor m?nimo por ano, a ser pago no vencimento inicial de professores que possuem forma??o em n?vel m?dio e jornada de trabalho de 40 horas. No RN, os resultados apontam que a implementa??o do PSPN apresenta repercuss?es positivas com os reajustes nos vencimentos dos professores e especialistas no per?odo citado. Ocorre, tamb?m, maior investimento via Fundeb no vencimento com o crescimento da sua receita. Em consequ?ncia, a percentagem desse aumento, no vencimento equivaleu a 88% e 86% na remunera??o. Nesse contexto, ocorreram, tamb?m, embates pol?ticos em ?mbito do Sinte/RN e governo no sentido de garantir os reajustes do PSPN, bem como a normatiza??o das horas atividades.<br>The present paper discusses the repercussions of National Professional Base Salary (PSPN) at maturity of the teaching professionals of the public schools of Rio Grande do Norte (RN) in the period 2008-2014, through the implementation of the Law No. 11,738 / 2008 , considering the adversarial and similarities between the government and the Labor Union in Education of RN State (Sinte / RN). It was used the bibliographic and documentary research, as well as information from the Career and Remuneration Plan (PCCR) from the teachers of the RN?s state network, approved by the Complementary Law No. 322/2006, the teaching payrolls (reference month of October) and their summaries ceded by the Department of Administration and Human Resources of RN (SEARH-RN). The theoretical studies show that, from the 1988 Federal Constitution, magisterium's valuation policy has been the scene of debates in the agenda of educational policy, determining its guidelines and form of financing, by Accounting Funds ? the Funding for Maintenance and Development of Elementary School and Valorization of Teaching (FUNDEF) and the unding for Maintenance and Development of Basic Education and Valorization of Teaching (Fundeb) ?, resolutions of the National Council of Education and the Law of the Wage Floor. These laws aim to guarantee rights assured, under training, working conditions, maturity and remuneration of teachers. The Law No. 11.738/08 of PSPN establishes the minimum value per year, to be payed at the initial maturity of teachers who have training in mid-level and the working day of 40-hour. In RN, the results indicate that the implementation of PSPN has positive repercussions with the readjustment of maturity of teachers and experts in that period. It also happens a bigger investment by Fundeb in the maturity with the growth of its revenue. In consequence, the percentage of this increase, in the maturity amounted to 88% and 86% in the remuneration. In this context there were also political clashes in the context of Sinte/RN and the government to guarantee the readjustments of PSPN, as well as the standardization of the activities hours.

Knowledge has been recognized as an important resource that should be carefully managed in order to enhance organizational competitiveness. Therefore, it is important to manage knowledge resources that have been learned and stored in organizations. Several scholars in the public administration literature have examined whether public service motivation (PSM) can help employees share their knowledge in ways that contribute to the effective functioning of public organizations. However, the mechanisms by which PSM influences individuals’ propensity to share knowledge have not been clarified by past research. Against this background, at first, this study contributes to understanding the relationship between PSM and knowledge sharing by applying self-determination theory with a logical insight of the intrinsic knowledge sharing motivation process. This study also examined that relationship by testing three competing psychological mechanisms based on person-environment (P-E) fit theory: (1) person-group (P-G) fit, (2) person-job (P-J) fit, and (3) person-supervisor (P-S) fit. The research questions for this study are as follows: Do individuals with higher levels of PSM have a higher propensity toward knowledge sharing? Does the congruence between employees and their work environment increase employees’ knowledge sharing behavior? Do PSM-driven employees have higher willingness to fit in the work environment? Does P-E fit theory help explain the causal relationship between PSM and knowledge sharing? Based on primary data of 1,094 occupationally diverse employees working in 33 local governments in South Korea, the current study found that caution should be exercised when making claims regarding the effects of PSM on individuals’ propensity to share knowledge and that greater emphasis should be placed on ways public sector organizations can foster P-G fit and P-J fit. However, this study also found that the relationship between PSM and knowledge sharing is not mediated by the extent to which employees perceive that their values are congruent with those of their supervisors. Keywords: public service motivation (PSM), person-environment fit (P-E fit), person-group fit (P-G fit), person-job fit (P-J fit), person-supervisor fit (P-S fit), knowledge sharing

Made available in DSpace on 2014-12-17T15:38:48Z (GMT). No. of bitstreams: 1 FabianaLS.pdf: 655458 bytes, checksum: e94bc91d973d0c27aac0a995d1542a52 (MD5) Previous issue date: 2004-05-14<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>The model of attention to health has been suffering alterations due to the difficulty faced to put into practice its universal, democratic and institutional layout. Since the movement of Sanitary Reform, which focused in the demands of a new health context and the process of work in the area of health, one seeks uninterruptedly, to find a way which leads to the execution of the principles of SUS. Despite having tried, the model of Sanitary Vigilance centered within the work of a multi-professional team has shown fragmentation and little adequacy to the necessity of health in the population. Whilst inserting himself in the field of health, the psychology professional has taken with him his clinic way of attending to individuals being one more in the team to act in a de-contextualised and little critical way. In virtue of this framework, the Ministry of Health invests in the Family Health Program as a new guide in the health system, restructuring the basic attention at a new logic of action. In this way, the municipality of Natal-RN implants, in the year 2002, the PSF in the Northern Sanitary District, a context in which professional teams are created where there is not an inclusion of a psychologist. Consequently, this professional is excluded of his work space in the previous Basic Unities of Health. This piece of work constitutes in the investigation of the implementation and instrumentalization of the Northern Sanitary District PSF of Natal-RN, having as its objective to analyze the implications of this execution for the structuring of the health network services and more specifically the alterations that this implementation could be making to the practice of the Psychology Professionals, emphasizing its advances, obstacles and limitations. To make this work feasible it was necessary to search for data and information from the implementation and execution of the PSF in the DSN, carrying interviews from a semi-structured guide, with 21 institutional actors (members of the team, coordinators and directors of the unities and psychologists)<br>O modelo de aten??o ? sa?de vem sofrendo altera??es em face da dificuldade enfrentada para p?r em pr?tica seu desenho institucional universalista e democr?tico. Desde o Movimento da Reforma Sanit?ria, que p?s em pauta a exig?ncia de um novo contexto de sa?de e o pr?prio processo de trabalho em sa?de, busca-se, ininterruptamente, encontrar um caminho que leve ? efetiva??o dos princ?pios do SUS. Embora o modelo da vigil?ncia sanit?ria - centrada na atua??o de uma equipe multiprofissional - tenha tentado, mostrou-se fragmentado e pouco adequado ?s necessidade de sa?de da popula??o. Ao inserir-se no campo da sa?de, profissional de psicologia levou consigo seu modelo cl?nico de atendimento, sendo mais um - na equipe - a atuar de forma descontextualizada e pouco cr?tica. Em virtude dese quadro, o Minist?rio da Sa?de investe no Programa Sa?de da Fam?lia enquanto novo orientador do sistema de sa?de, resstruturando a aten??o b?sica sob uma nova l?gica de a??o. Nesse sentido, o munic?pio de Natal-RN, implanta, no ano de 2002, PSF no Distrito Sanit?rio Norte, contexto em que s?o criadas equipes de profissionais nas quais n?o h? inclus?o do psic?logo. Conseq?entemente, esse profissional ? exclu?do de seu espa?o de trabalho nas antigas Unidades B?sicas de Sa?de.Este trabalho constitui-se na investiga??o da implanta??o e instrumentaliza??o do PSF no Distrito Sanit?rio Norte de Natal-RN, tendo como objetivo analisar as implica??es dessa efetiva??o para a estrutura??o da rede de servi?os e mais especificamente as altera??es que essa implanta??o possa estar imprimindo ? pr?tica dos profissionais de Psicologia, destacando seus avan?os, entraves e limites. Para realizar tal estudo se fez neces?rio buscar dados e informa??es da implanta??o e efetiva??o do PSF no DSN, realizandoainda entrevistas, a partir de um roteiro semi-estruturado, com 21 atores institucionais (integrantes de equipes, coordenaodres e diretores de unidades de sa?de e psic?logos)

Le plasma de quarks et de gluons est un état de la matière apparaissant à haute température. En laboratoire, il est possible d'atteindre les conditions nécessaires à sa formation grâce aux collisions d'ions lourds aux énergies ultra-relativistes. L'expérience ALICE au LHC est dédiée à l'étude du plasma de quarks et de gluons grâce aux collisions Pb-Pb à 2,76 TeV. Les premiers résultats d'ALICE, presentés en annexe, ont été obtenus grâce aux rayons cosmiques. Une étude de l'évolution de l'efficacité de reconstruction du spectromètre à muons durant ses deux premières années de fonctionnement sera présentée par la suite. L'efficacité totale de reconstruction des chambres de trajectographie ainsi obtenue est de plus de 90% pour les données correspondant à des collisions proton-proton, et de 85% pour les données recueillies avec des collisions plomb-plomb. Une méthode de sélection des traces reposant sur la distribution du produit impulsion - distance d'approche minimale sera également présentée. Cette sélection permet de rejeter les traces de muons produits par des collisions entre les particules du faisceau et le gaz résiduel dans le tube faisceau, et les fausses traces dans les collisions Pb-Pb les plus centrales. Enfin, cette thèse présentera une première analyse sur le taux de production des muons simples et des J/psi en fonction de la multiplicité en particules chargées lors des collisions proton-proton.

La ricerca è stata condotta in una realtà organizzativa multinazionale, con lo scopo di comprendere quale sia il ruolo giocato dalle Nuove Tecnologie (NT) nel processo di integrazione tra Knowledge Management (KM) e Formazione. Queste due aree, infatti, potrebbero reciprocamente supportarsi nella capitalizzazione della conoscenza prodotta in azienda. Il primo studio ha esplorato la cultura organizzativa attraverso l’analisi delle comunicazioni sull’intranet. Con il secondo studio sono stati approfonditi vissuti e rappresentazioni dei membri dell’organizzazione; sono state condotte interviste etno-narrative ai responsabili dell’area Formazione, del KM ed ai Facilitatori delle Comunità di Pratica (CoP) per far emerge le pratiche d’uso delle NT. Nel terzo studio è stato indagato il costrutto della partecipazione alle CoP Virtuali, strumento indispensabile per rendere capillari le attività del KM. Il questionario compilato dai membri di alcune delle CoP aziendali ha mostrato come l’influenza di un fattore soggettivo e di uno sociale favoriscano la partecipazione alle attività. Dagli studi è emerso che la creazione di spazi prossimali di apprendimento riconosciuti e di un ambiente per la social collaboration consentirebbero il passaggio ad un sistema integrato ed un cambiamento nella cultura d’uso. Risulta fondamentale anche l’apporto di alcune figure chiave interne all’azienda, unito ad interventi di educazione all’uso.<br>Aim of the research, conducted in a multinational organization, is understanding the role played by New Technologies (NT) in the process of integration of Knowledge Management (KM) and Learning. These two areas, in fact, could support reciprocally in the capitalization of the knowledge produced in the company. The first study explores the organizational culture through the analysis of communication on the intranet. The second study looks at organization’s members experiences and representations. Ethno-narrative interviews were conducted to the training and KM areas managers, and to Communities of Practice’s (CoPs) Facilitators, to understand the NT’s practices of use. The third study investigates the construct of participation in Virtual CoPs, an essential tool to make widespread KM activities. The questionnaire completed by members of some Company’s CoPs showed how one subjective and one social factors encourage participation in activities. These studies show that the creation of spaces of recognized proximal learning and a social collaboration environment can enable the transition to an integrated system, and a change in the culture of usage. It is also essential the contribution of some key figures within the Company, combined with education to usage.

Pressure swing adsorption (PSA) is a widely applied technology for separating gases, which operates based on selective adsorption on solid adsorbents. Indeed, the demand of PSA process plants for nitrogen production on industrial scale is continuously growing, as consequence of the improvements achieved in terms of efficiency, competitiveness, and cost-effectiveness. In this work, the N2-PSA pilot plant located at the Münster University of Applied Sciences, was used as study-case for the drafting of the industrial-scale basic design package of the plant. Firstly, it was shown that it is acceptable to develop the basic design package of full-scale PSA system based on information obtained by operation of pilot-scale system. Subsequently, a detailed description of technical data of plant components has been given, according to the international and European standards in force. Therefore, it was possible to produce technical drawings of the plant, i.e. process flow diagram (PFD) and piping and instrumentation diagram (P&ID), along with the required datasheets and a preliminary plant layout. Eventually, a preliminary safety assessment of the system was carried out.

Il 40 per cento degli intervistati afferma che non ha trovato informazioni esaustive sui rischi e benefici dei farmaci trovati, mentre il 52 per cento afferma che le informazioni trovate hanno aiutato a seguire le indicazioni e i consigli del medico. Tra i rispondenti che si sono sottoposti a visita medica e che hanno discusso le informazioni trovate online con il proprio medico di fiducia, l'84 per cento ha ricevuto la prescrizione di farmaci. Di questi, solo il 17 per cento riporta che il farmaco prescritto era lo stesso trovato online, il 74 per cento è stato inviato da uno specialista e l'80 per cento ha ricevuto una prescrizione per test diagnostici. Più della metà dei rispondenti ha anche riportato azioni intraprese dal medico diverse dalla prescrizione del farmaco trovato online. Il 20 per cento degli intervistati afferma che le informazioni trovate sul farmaco da prescrizione in Internet hanno ridotto il suo / la sua fiducia nel medico, mentre il 41 per cento afferma che lo ha aiutato ad avere una comunicazione migliore con il proprio medico di fiducia. Nonostante le preoccupazioni sulle conseguenze negative della comunicazione di salute online, non abbiamo riscontrato differenze in termini di effetti sulla salute tra i pazienti che hanno assunto i farmaci “menzionati” online e coloro che hanno preso altri farmaci da prescrizione.<br>We conducted a national online survey about health care experiences associated with digital communication of prescription drugs. 46 percent of the sample (265 adults) found information about prescription drugs during their online search in the last 12 months. 40 percent of respondents agreed they didn’t find exhaustive information about risks and benefits while 52 percent agreed it helped in following their physician’s indications and advise. Among the respondents who had a physician visit during which health information found online was discussed, 84 percent received a drug prescription with only 17 percent being the same drug found on internet, 74 percent was sent to a specialist and 80 percent received a diagnostic test prescription. More than half also reported actions taken by their physician other than prescribing the drug brand found online. 20 percent respondents states that info found on the prescription drug in Internet reduced his/her trust in the physician while 41 percent states it helped in his/her communication with physician. Despite concerns about online health communication’s negative consequences, we found no differences in health effects between patients who took “advocated”/”mentioned” drugs and those who took other prescription drugs.

碩士<br>國立成功大學<br>物理學系<br>104<br>The Solenoid Tracker at RHIC (STAR) is one of the major experiments in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory. In 2013, a new detector – Muon Telescope Detector (MTD) is installed about 63% of the full system and completely installed in 2014. It provides an excellent opportunity to study heavy quarkonia physics using dimuon channel in the experiments. We studied the muon identification using three different methods with proton-proton collision at sqrt(s) = 500 GeV data collected in 2013. The result shows that the muon identification efficiencies reaches about 80% with p_T 〉 3 GeV/c. The measurement of the J/psi invariant cross section is also studied using dimuon decay channel with Likelihood Ratio method for muon identification. The results in dimuon channel are consistent with the results in dielectron channel in the overlap p_T region and have good agreement with the CGC+NRQCD prediction.

碩士<br>國立臺灣大學<br>物理研究所<br>94<br>We study the baryonic charmonium decays of B mesons, B+ to etac K+ and B+ to J/psi K+, where the etac and J/psi subsequently decay into a p pbar or Lambda Lambdabar pair. We measure the J/psi to p pbar, Lambda Lambdabar anisotropy parameters, alpha_B = -0.60 +- 0.13 +-0.14 (p pbar), -0.44 +- 0.51 +- 0.31 (Lambda Lambdabar) and compare to results from e+e- to J/psi formation experiments. We also report the first observation of etac to Lambda Lambdabar. The measured branching fraction is B(etac to Lambda Lambdabar) = (0.87 +0.24 -0.21(stat) +0.09 -0.14(syst) +- 0.27 (PDG)) x 10^-3. This study is based on a 357 fb^-1 data sample recorded on the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider.

This thesis provides a general methodology for classifying and describing many combinatoric problems, systematising and finding theoretical expressions for quantities of interest, and investigating their feasible numerical evaluation. Unifying notation and definitions are provided. Our knowledge of random allocations is also extended. This is achieved by investigating new processes, generalising known processes, and by providing a formal structure and innovative techniques for analysing them. The random allocation models described in this thesis can be classified as occupancy urn models, in which we have a sequence of urns and throw balls into them, and investigate static, waiting-time and dynamic processes. Various structures are placed on the relationship(s) between cells, balls, and the selection of items being distributed, including varieties, batch arrivals, taboo sets and blocking sets. Static, waiting-time and dynamic processes are investigated. Both without-replacement and with-replacement sampling types are considered. Emphasis is placed on the distributions of waiting-times for one or more events to occur measured from the time a particular event occurs; this begins as an abstraction and generalisation of a model of departures of cars parked in lanes. One of several additional determinations is the platoon size distribution. Models are analysed using combinatorial analysis and Markov Chains. Global attributes are measured, including maximum waits, maximum room required, moments and the clustering of completions. Various conversion formulae have been devised to reduce calculation times by several orders of magnitude. New and extended applications include Queueing in Lanes, Cake Displays, Coupon Collector's Problem, Sock-Sorting, Matching Dependent Sets (including Genetic Code Attribute Matching and the game SET), the Zig-Zag Problem, Testing for Randomness (including the Cake Display Test, which is a without-replacement test similar to the standard Empty Cell test), Waiting for Luggage at an Airport, Breakdowns in a Network, Learning Theory and Estimating the Number of Skeletons at an Archaeological Dig. Fundamental, reduction and covering theorems provide ways to reduce the number of calculations required. New combinatorial identities are discovered and a well-known one is proved in a combinatorial way for the first time. Some known results are derived from simple cases of the general models.<br>http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1309598<br>Thesis (Ph.D.) -- University of Adelaide, School of Mathematical Sciences, 2007