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Shaik, Jameel, Javeed Shaikh Mohammed, Michael J. McShane, and David K. Mills. "Chondrocyte Behavior on Micropatterns Fabricated Using Layer-by-Layer Lift-Off: Morphological Analysis." Journal of Medical Engineering 2013 (May 28, 2013): 1–12. http://dx.doi.org/10.1155/2013/560328.
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Cell patterning has emerged as an elegant tool in developing cellular arrays, bioreactors, biosensors, and lab-on-chip devices and for use in engineering neotissue for repair or regeneration. In this study, micropatterned surfaces were created using the layer-by-layer lift-off (LbL-LO) method for analyzing canine chondrocytes response to patterned substrates. Five materials were chosen based on our previous studies. These included: poly(dimethyldiallylammonium chloride) (PDDA), poly(ethyleneimine) (PEI), poly(styrene sulfonate) (PSS), collagen, and chondroitin sulfate (CS). The substrates were patterned with these five different materials, in five and ten bilayers, resulting in the following multilayer nanofilm architectures: (PSS/PDDA)5, (PSS/PDDA)10; (CS/PEI)4/CS, (CS/PEI)9/CS; (PSS/PEI)5, (PSS/PEI)10; (PSS/Collagen)5, (PSS/Collagen)10; (PSS/PEI)4/PSS, (PSS/PEI)9/PSS. Cell characterization studies were used to assess the viability, longevity, and cellular response to the configured patterned multilayer architectures. The cumulative cell characterization data suggests that cell viability, longevity, and functionality were enhanced on micropatterned PEI, PSS, collagen, and CS multilayer nanofilms suggesting their possible use in biomedical applications.
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Le Guern, V., C. Belin, C. Henegar, C. Moroni, D. Maillet, C. Lacau, J. L. Dumas, N. Vigneron, and L. Guillevin. "Cognitive function and 99mTc-ECD brain SPECT are significantly correlated in patients with primary Sjögren syndrome: a case–control study." Annals of the Rheumatic Diseases 69, no. 01 (January 21, 2009): 132–37. http://dx.doi.org/10.1136/ard.2008.090811.
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Objectives:To assess subclinical central nervous system (CNS) involvement in primary Sjögren syndrome (pSS), by comparing standard brain MRI, in-depth neuropsychological testing and 99mTc-ECD brain single-photon emission computed tomography (SPECT) of patients with pSS with matched controls.Methods:10 women (<55 years old), with pSS defined using European–American criteria, presence of anti-SSA and/or anti-SSB antibodies and no history of neurological involvement were prospectively investigated, and compared with 10 age- and sex-matched controls. All subjects underwent, within 1 month, brain MRI, neuropsychological testing, including overall evaluation and focal cognitive function assessment, and 99mTc-ECD brain SPECT.Results:99mTc-ECD brain SPECT abnormalities were significantly more common in patients with pSS (10/10) than controls (2/10; p<0.05). Cognitive dysfunctions, mainly expressed as executive and visuospatial disorders, were also significantly more common in patients with pSS (8/10) than controls (0/10; p<0.01). Notably, between-group comparisons enabled a significant correlation to be established between neuropsychological assessment and 99mTc-ECD brain SPECT abnormalities in patients with pSS (rs = 0.49, p<0.01). MRI abnormalities in patients and controls did not differ significantly.Conclusions:Neuropsychological testing and 99mTc-ECD brain SPECT seem to be the most sensitive tools to detect subclinical CNS dysfunction in pSS. The strong correlation between cortical hypoperfusion in 99mTc-ECD brain SPECT and cognitive dysfunction suggests an organic aetiology of CNS dysfunction in pSS. These data should be confirmed in a larger study.
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Figalová, Nikol, and Miroslav Charvát. "The perceived stress scale: Reliability and validity study in the Czech Republic." Ceskoslovenska psychologie 65, no. 1 (February 28, 2021): 46–59. http://dx.doi.org/10.51561/cspsych.65.1.46.
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Objectives. The aim of this study was to create a Czech translation of the Perceived Stress Scale (PSS), to assess its psychometric properties on a representative sample of the Czech general adult population, and to compare the original 14-item version (PSS-14) with the shortened 10-item (PSS-10) and four-item (PSS-4) versions. Sample and setting. Two pilot studies were conducted to create the final Czech translation of the scale (n = 365 and n = 420). The final version of the Czech PSS was administered to a sample of the Czech general adult population (n = 1725 of whom 981 were women, M = 44.32, SD = 12.8). The Beck Depression Inventory (BDI-II) or the State-Trait Anxiety Inventory (STAI) were administered alongside the PSS to a part of the sample. A retest measurement after 14 days was conducted (n = 159). Statistical analysis. Using the confirmatory factor analysis, the one-factor, two-factor and bifactor models were compared. The internal consistency, stability in time, and convergent validity of the scale, as well as the known-group differences, were assessed. The three versions of the PSS were compared. Results. The confirmatory factor analysis supported the bifactor model of the PSS-14 and PSS-10, and the two-factor model of the PSS-4. All versions of the scale showed good internal consistency and stability in time. There was a moderate to strong positive correlation between the PSS and the BDI-II and STAI. Differences based on age, sex, education level, and situational factors were found. Overall, the PSS-10 showed the best psychometric properties of all three versions of the scale. Study limitation. The sample consisted mostly of highly educated respondents.
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Chen, Julie Yun, Weng-Yee Chin, Agnes Tiwari, Janet Wong, Ian C. K. Wong, Alan Worsley, Yibin Feng, Mai Har Sham, Joyce Pui Yan Tsang, and Chak Sing Lau. "Validation of the perceived stress scale (PSS-10) in medical and health sciences students in Hong Kong." Asia Pacific Scholar 6, no. 2 (May 4, 2021): 31–37. http://dx.doi.org/10.29060/taps.2021-6-2/oa2328.
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Introduction: The demanding nature of medical and health sciences studies can cause stress among students in these disciplines affecting their wellbeing and academic performance. The Perceived Stress Scale (PSS-10) is a widely used measure of perceived stress among medical students and healthcare professionals that has not yet been validated among medical and health sciences students in Hong Kong. The aim of this study is to establish the construct validity and reliability of the PSS-10 in this context. Methods: 267 final year medical and health sciences students were surveyed using the PSS-10. The data were analysed using exploratory factor analysis for construct validity and Cronbach’s alpha coefficient and corrected item-total correlations for reliability. Results: Exploratory factor analysis revealed a two-factor structure for PSS-10, with Cronbach’s alpha of 0.865 and 0.796, indicating good internal consistency. Corrected item-total correlations showed satisfactory correlation ranged from 0.539 to 0.748 for all items and their respective subscale. Both tests supported PSS-10 as a two-factor scale. Conclusion: The PSS-10 is a valid measure for assessing perceived stress in Hong Kong medical and health sciences students.
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Wu, Salene M., and Dagmar Amtmann. "Psychometric Evaluation of the Perceived Stress Scale in Multiple Sclerosis." ISRN Rehabilitation 2013 (December 22, 2013): 1–9. http://dx.doi.org/10.1155/2013/608356.
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Multiple sclerosis (MS) is a progressive disease characterized by neurological symptoms and sometimes heightened levels of distress. The Perceived Stress Scale (PSS) is often used in MS samples to measure stress but has not been validated in this population. Participants (n=446) completed the PSS as well as measure of depression, anxiety, and mental and physical health. Factor analyses indicated that the general factor of a bifactor model accounted for a large amount of the variance in the 14-item and 10-item versions of the PSS. The 4-item PSS had two factors, the Stress subscale and the Coping subscale, but a one-factor model also fits the data well. Total scores and both subscales had sufficient reliability and validity for all versions of the PSS, although a few items of the 14-item PSS had low item-total correlations. This study supports the use of the total score of the PSS in MS but also suggests that the 10-item PSS had better psychometric properties than the 14-item PSS.
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Lee, K. Y., P. Biancani, and J. Behar. "Calcium sources utilized by cholecystokinin and acetylcholine in the cat gallbladder muscle." American Journal of Physiology-Gastrointestinal and Liver Physiology 256, no. 4 (April 1, 1989): G785—G788. http://dx.doi.org/10.1152/ajpgi.1989.256.4.g785.
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The calcium sources responsible for gallbladder contraction in response to cholecystokinin (CCK) and acetylcholine were studied in vitro in the cat. Sudden replacement of normal physiological salt solution (PSS) with calcium-free PSS blocked the contraction induced by KCl (60 mM) but did not affect the response to CCK (10(-7) M) or acetylcholine (3 x 10(-3) M). Thirty-minute incubation in PSS in which strontium (2.5 mM) was substituted for calcium blocked completely CCK (10(-10) - 10(-6) M)-induced contraction without impairing the response to acetylcholine (10(-7) - 10(-3) M) or KCl (20-80 mM). The contraction induced by acetylcholine (10(-7) - 10(-3) M) was partially blocked by hydroxyverapamil (D-600) (10(-5) M) in normal PSS (Ca 2.5 mm) and was completely blocked by D-600 in strontium (2.5 mm)-containing solution. It is concluded that CCK contracts the gallbladder muscle by mobilizing calcium from intracellular stores, whereas acetylcholine can utilize calcium both from intracellular or extracellular sources.
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Kotas, Roman, Marta Nowakowska-Kotas, Sławomir Budrewicz, and Anna Pokryszko-Dragan. "The Level of Stress and Coping Strategies in Patients with Multiple Sclerosis and Their Relationships with the Disease Course." Journal of Clinical Medicine 10, no. 17 (August 30, 2021): 3916. http://dx.doi.org/10.3390/jcm10173916.
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Objectives: Stress is supposed to be linked with a background of multiple sclerosis (MS) and the disease course. Design: The study aimed to assess the level of stress and coping strategies in MS patients within a year of follow-up and to investigate the relationships between these aspects and factors related—or not—to MS. Methods: In 65 patients with MS, the Perceived Stress Scale (PSS-10), Type D Scale (DS14) and Coping Orientations to Problems Experienced (COPE) were performed at baseline and after a year. Baseline PSS-10, DS-14 and COPE scores were analyzed with regard to demographics, MS duration, treatment, indices of disability and self-reported stressful events (SEs). Final PSS-10 and COPE results were analyzed with reference to MS activity and SE within a year of follow-up. Results: Initially, 67% of patients reported a moderate or high level of stress and 31% met Type-D personality criteria. Diverse coping strategies were preferred, most of which were problem-focused. The negative affectivity DS-14 subscore (NEG) was correlated with disability level. Non-health-related SEs were associated with higher PSS-10 and NEG scores. After a year, the mean PSS-10 score decreased, while COPE results did not change significantly. Non-health-related SEs were associated with a higher PSS-10 score and less frequent use of acceptance and humor strategies. Those with an active vs. stable MS course during the follow-up did not differ in terms of PSS-10 and COPE results. Conclusions: MS patients experienced an increased level of stress. No significant relationships were found between stress or coping and MS course within a year. Non-health-related factors affected measures of stress more than MS-related factors.
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Chiu, Yi-Hsiang, Frank Jing-Horng Lu, Ju-Han Lin, Chiao-Lin Nien, Ya-Wen Hsu, and Hong-Yu Liu. "Psychometric properties of the Perceived Stress Scale (PSS): measurement invariance between athletes and non-athletes and construct validity." PeerJ 4 (December 15, 2016): e2790. http://dx.doi.org/10.7717/peerj.2790.
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BackgroundAlthough Perceived Stress Scale (PSS, Cohen, Kamarack & Mermelstein, 1983) has been validated and widely used in many domains, there is still no validation in sports by comparing athletes and non-athletes and examining related psychometric indices.PurposeThe purpose of this study was to examine the measurement invariance of PSS between athletes and non-athletes, and examine construct validity and reliability in the sports contexts.MethodsStudy 1 sampled 359 college student-athletes (males = 233; females = 126) and 242 non-athletes (males = 124; females = 118) and examined factorial structure, measurement invariance and internal consistency. Study 2 sampled 196 student-athletes (males = 139, females = 57,Mage = 19.88 yrs, SD = 1.35) and examined discriminant validity and convergent validity of PSS. Study 3 sampled 37 student-athletes to assess test-retest reliability of PSS.ResultsResults found that 2-factor PSS-10 fitted the model the best and had appropriate reliability. Also, there was a measurement invariance between athletes and non-athletes; and PSS positively correlated with athletic burnout and life stress but negatively correlated with coping efficacy provided evidence of discriminant validity and convergent validity. Further, the test-retest reliability for PSS subscales was significant (r = .66 andr = .50).DiscussionIt is suggested that 2-factor PSS-10 can be a useful tool in assessing perceived stress either in sports or non-sports settings. We suggest future study may use 2-factor PSS-10 in examining the effects of stress on the athletic injury, burnout, and psychiatry disorders.
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Trigo, Miguel, Noélia Canudo, Fernando Branco, and Danilo Silva. "Estudo das propriedades psicométricas da Perceived Stress Scale (PSS) na população portuguesa." Psychologica, no. 53 (December 1, 2010): 353–78. http://dx.doi.org/10.14195/1647-8606_53_17.
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Objectivo: Estudar as propriedades psicométricas da versão portuguesa da Perceived Stress Scale-10 (PSS-10). Amostra: Cinco amostras da população geral (n = 762) e cinco amostras de pessoas com doença física ou perturbação ansiosa (n = 201). Medidas: Dados socio-demográficos, hábito tabágico, Beck Depression Inventory® (BDI®), PSS-10, State-Trait Anxiety Inventory® (STAI®-Y2) e Smoking Abstinence Self-Efficacy (SASE-12). Resultados: Pela análise em componentes principais, reteve-se um factor que explica 47,4% da variância. O alfa de Cronbach foi de 0,874 e encontraram-se diferenças significativas na percepção do stresse, em diversos estratos da população. Existem correlações moderadas entre a PSS-10, o BDI® e o STAI®-Y2 e ausência de associação com o SASE-12. Consideram-se indicador de patologia pontuações brutas acima do percentil 80. Conclusões: A PSS-10 apresenta boas qualidades psicométricas. A sua aplicação e cotação é simples, constituindo um instrumento válido para avaliar o stresse, em contextos de doença física ou condições psicopatológicas.
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Frederiksen, Trine Brink, Marina P. P. Pieroni, Daniela C. A. Pigosso, and Tim C. McAloone. "Strategic Development of Product-Service Systems (PSS) through Archetype Assessment." Sustainability 13, no. 5 (March 1, 2021): 2592. http://dx.doi.org/10.3390/su13052592.
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Product-service systems (PSS) enable product-oriented manufacturing companies to differentiate their offerings and become more competitive, while creating more value for customers along with improved economic performance and, in some cases, reduced environmental impact. However, PSS development remains difficult for manufacturing companies due to limited prior knowledge about PSS and the strategic characteristics it entails. To guide the PSS development process, this paper presents a prescriptive approach composed of a tool and a method based on the use of PSS archetypes in the initial development stages of new PSS business models (BM). The proposed tool builds upon three PSS archetypes, combined with 10 factors for assessment of the best suiting archetype. The proposed method and supporting tool guide companies in five steps, from the beginning of a servitisation process to the initial PSS development. Based on an evaluation with a Danish manufacturing company, an improved version of the method and tool was developed and applied with 60 students specialised in PSS development. Results from the evaluation indicate that the method and tool support scoping new PSS BM through the selection and modification of a PSS archetype, encouraging servitisation and PSS development in companies with different levels of PSS experience.
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McLeod, Caroline, Myla D. Ebeling, John E. Baatz, Judy R. Shary, Jennifer R. Mulligan, and Carol L. Wagner. "Sociodemographic factors affecting perceived stress during pregnancy and the association with immune-mediator concentrations." Journal of Perinatal Medicine 50, no. 2 (November 10, 2021): 192–99. http://dx.doi.org/10.1515/jpm-2021-0227.
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Abstract Objectives Determine which sociodemographic factors are most associated with increased maternal perceived stress during pregnancy. Evaluate the association between maternal stress and plasma immune-mediator concentrations (IMCs). Methods As part of a prospective, randomized clinical trial, 247 participants completed a Perceived Stress Scale survey (PSS-10) during each trimester of pregnancy. Blood samples were collected from participants and were analyzed for 25-hydroxyvitamin D (25(OH)D) concentration and for several IMCs: interferon-gamma, interleukins (IL-) IL-2, IL-4, IL-5, IL-10, vascular endothelial growth factor, c-reactive protein, and tumor necrosis factor alpha (TNF-α) (R&D Elisa). The potential associations between PSS-10 scores, sociodemographic factors, and IMCs were assessed. Results In bivariate analysis, participants who were not married and/or had high risk pregnancies were more likely to have increased PSS-10 scores (p<0.05). Increased PSS-10 scores were associated with higher serum concentrations of IL-2 and TNF-α, and decreased concentrations of IL-10 and 25(OH)D. In linear regression analysis, single marital status, high-risk pregnancy, IL-2, and TNF-α were independent predictors of PSS-10 scores. Conclusions This study identifies specific sociodemographic factors that are associated with increased perceived stress during pregnancy. This study also provides evidence that increased perceived stress is associated with physiological changes as measured by changes in circulating IL-2, TNF-α, IL-10, and 25(OH)D concentrations.
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Goulabchand, Radjiv, Audrey Gabelle, Xavier Ayrignac, Nicolas Malafaye, Pierre Labauge, Danièle Noël, Jacques Morel, et al. "Hospitalization Risks for Neurological Disorders in Primary Sjögren’s Syndrome Patients." Journal of Clinical Medicine 11, no. 7 (April 1, 2022): 1979. http://dx.doi.org/10.3390/jcm11071979.
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Primary Sjögren’s syndrome (pSS) can be associated with neurological and cognitive involvement, negatively affecting patients’ quality of life. The aim of this study was to assess whether pSS patients are at higher risk of hospitalization for neurological diseases. Through a nationwide retrospective study using the French Health insurance database (based on International Classification for Disease codes, ICD-10), we selected patients hospitalized with new-onset pSS between 2011 and 2018. We compared the incidence of hospitalization for dementia, multiple sclerosis (MS), encephalitis, and peripheral neuropathy with an age- and sex-matched (1:10) hospitalized control group. Adjusted Hazard Ratios (aHR) considered confounding factors, particularly socio-economic status and cardiovascular diseases. We analyzed 25,661 patients hospitalized for pSS, compared with 252,543 matched patients. The incidence of hospitalization for dementia was significantly higher in pSS patients (aHR = 1.27 (1.04–1.55); p = 0.018), as well as the incidence of hospitalization for MS, encephalitis, and inflammatory polyneuropathies (aHR = 3.66 (2.35–5.68), p < 0.001; aHR = 2.66 (1.22–5.80), p = 0.014; and aHR = 23.2 (12.2–44.5), p < 0.001, respectively). According to ICD-10 codes, pSS patients exhibited a higher incidence of hospitalization for dementia, encephalitis, MS, and peripheral neuropathies than controls. Physicians must be aware of these neurological risks to choose the most appropriate diagnostic work-up.
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Galanopoulou, A. S., N. G. Seidah, and Y. C. Patel. "Direct role of furin in mammalian prosomatostatin processing." Biochemical Journal 309, no. 1 (July 1, 1995): 33–40. http://dx.doi.org/10.1042/bj3090033.
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We have previously reported that rat prosomatostatin (rPSS) undergoes conversion at Arg decreases and Lys decreases monobasic sites to SS-28 and PSS-(1-10) respectively in COS-7 cells, and have proposed furin or a related enzyme of the constitutive secretory pathway as the endoproteinase responsible. Here we have tested directly the ability of furin to cleave rPSS at the two monobasic sites as well as at the RXRK dibasic site of SS-14 conversion (a furin motif, except for Lys substituting for Arg at P1). Recombinant vaccinia virus (VV) vectors were used to co-express rPSS with graded doses of furin in COS-7 cells and LoVo colon carcinoma cells deficient in furin. PSS and cleavage products in cell extracts and media were characterized by HPLC analysis and C-terminal [SS-14-like immunoreactivity (SS-14 LI)] and N-terminal [PSS-(1-10) LI] directed radioimmunoassays. There was a dose-dependent increase in SS-28 production from rPSS by furin in COS-7 cells from 29% (control) to 58% (high-dose furin) associated with a progressive decrease in unprocessed PSS from > 60% to approximately 20% of total SS-14 LI. Significant SS-14 production occurred only at high levels of furin infection. Control LoVo cells infected with VV:rPSS exhibited production of approximately 21% SS-28, approximately 15% PSS-(1-10) and 3.5% SS-14. Infection of LoVo cells with VV:hfurin (hfurin = human furin) enhanced SS-28 production to 30-34%. SS-14 synthesis also increased to 25-40%, probably by conversion from SS-28. Overexpression of furin in COS-7 or LoVo cells failed to increase PSS-(1-10) production. These results show that furin is a candidate SS-28 convertase. Arginine is the preferred residue at the P1 site of furin cleavage. Furin does not process rPSS to PSS-(1-10), suggesting the existence of another monobasic convertase with a preference for Lys rather than Arg at P1. Such an enzyme could also explain the presence of endogenous SS-28-, PSS-(1-10)- and SS-14-producing activities in LoVo cells.
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García-Hernández, Celia, Cristina García-Cabezón, Fernando Martín-Pedrosa, José Antonio De Saja, and María Luz Rodríguez-Méndez. "Layered composites of PEDOT/PSS/nanoparticles and PEDOT/PSS/phthalocyanines as electron mediators for sensors and biosensors." Beilstein Journal of Nanotechnology 7 (December 8, 2016): 1948–59. http://dx.doi.org/10.3762/bjnano.7.186.
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The sensing properties of electrodes chemically modified with PEDOT/PSS towards catechol and hydroquinone sensing have been successfully improved by combining layers of PEDOT/PSS with layers of a secondary electrocatalytic material such as gold nanoparticles (PEDOT/PSS/AuNPs), copper phthalocyanine (PEDOT/PSS/CuPc) or lutetium bisphthalocyanine (PEDOT/PSS/LuPc2). Layered composites exhibit synergistic effects that strongly enhance the electrocatalytic activity as indicated by the increase in intensity and the shift of the redox peaks to lower potentials. A remarkable improvement has been achieved using PEDOT/PSS/LuPc2, which exhibits excellent electrocatalytic activity towards the oxidation of catechol. The kinetic studies demonstrated diffusion-controlled processes at the electrode surfaces. The kinetic parameters such as Tafel slopes and charge transfer coefficient (α) confirm the improved electrocatalytic activity of the layered electron mediators. The peak currents increased linearly with concentration of catechol and hydroquinone over the range of 1.5 × 10−4 to 4.0 × 10−6 mol·L−1 with a limit of detection on the scale of μmol·L−1. The layered composite hybrid systems were also found to be excellent electron mediators in biosensors containing tyrosinase and laccase, and they combine the recognition and biocatalytic properties of biomolecules with the unique catalytic features of composite materials. The observed increase in the intensity of the responses allowed detection limits of 1 × 10−7 mol·L−1 to be attained.
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Abe, S., H. Tsuboi, F. Honda, H. Takahashi, Y. Kondo, I. Matsumoto, and T. Sumida. "AB0122 DETECTION OF CIRCULATING M3 MUSCARINIC ACETYLCHOLINE RECEPTOR REACTIVE TH17 CELLS IN PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1361.2–1361. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1642.
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Background:Sjögren’s syndrome (SS) is an autoimmune disease which is characterized by lymphocytic infiltration including CD4+IL-17 producing helper T (Th17) cells to the lacrimal and salivary glands. We previously detected anti-M3 muscarinic acetylcholine receptor (M3R) antibodies (1) and M3R reactive CD4+IFNγ producing helper T (Th1) cells (2) in SS patients. Moreover, we clarified that M3R reactive Th1 and Th17 cells had pathogenic roles in the development of auto-immune sialadenitis in SS mouse model (3).Objectives:The purpose of this study was to identify circulating M3R reactive Th17 cells among primary SS (pSS) patients, and to determine functional properties of those cells.Methods:1)Peripheral blood mononuclear cells (PBMCs) were isolated from whole blood of 10 pSS patients, age gender matched 10 healthy controls (HC), and 5 IgG4-related disease (IgG4-RD) patients. According to their HLA-DRB1 typing, top 10 ranked 20 mer peptides from the full length of M3R, which were highly predicted to bind to each HLA molecules according to the immune epitope database website, were selected for each subjects. PBMCs were stimulated with these selected M3R peptides mixed for 40 hours, and M3R peptide reactive IL-17 secreting cells were detected by IL-17 enzyme-linked immunospot assay (ELISpot).2)PBMCs from 5 pSS patients who were positive for M3R specific IL-17 secreting cells, were stimulated with selected 12-20 mer M3R peptides separately, to identify the dominant M3R peptides responsible for IL-17 secretion by ELISpot.3)To identify whether detected IL-17 secreting cells were Th17 cells or not, isolated CD4+T cells from 3 pSS patients who were positive for M3R specific IL-17 secreting cells, were co-cultured with auto-monocyte derived dendritic cells (DCs), and stimulated with the dominant IL-17 secreting M3R peptides detected in method 2.4)Anti-M3R antibodies were examined using ELISA method.5)Clinical features were compared between M3R specific Th17 cells positive and negative pSS patients.Results:1)5 of 10 (50%) pSS patients, while none of 10 (0%) HC, and 5 (0%) IgG4-RD patients, showed significantly increased IL-17 positive spots against selected M3R peptides mixed stimulation compared with non-stimulation in ELISpot (Figure 1). M3R specific IL-17 secreting cells were detected significantly more frequently in pSS (5/10, 50%) than in HC (0/10, 0%) (p=0.03).2)All 5 pSS patients, who were positive for M3R specific IL-17 secreting cells, showed significantly increased IL-17 positive spots against M3R AA76-95 peptides.3)Co-culturing CD4+ T cells with DCs, stimulated with identified dominant M3R peptides in method 2, showed significantly increased spots, clarifying that IL-17 secreting cells were peripheral M3R reactive Th17 cells.4)Titers of anti-M3R antibodies were significantly higher among M3R reactive Th17 cells positive pSS patients than negative pSS patients.5)5 pSS patients positive for M3R reactive Th17 cells had significantly higher disease activity score (ESSDAI: 8.0±4.3) than 5 negative pSS patients (2.8±1.7) (P=0.01).Conclusion:We detected circulating M3R reactive Th17 cells in pSS patients using ELISpot, whose T cell epitopes were shown to be included in M3R AA76-95. Moreover, M3R reactive Th17 cells might correlate with higher disease activity and production of anti-M3R antibodies in pSS patients.References:[1]Tsuboi H, et al. New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome.Clin Exp Immunol2010;162:53-61[2]Naito Y, et al. Altered peptide ligands regulate muscarinic acetylcholine receptor reactive T cells of patients with Sjögren’s syndrome.Ann Rheum Dis2005;65:269-71[3]Iizuka M, et al. Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren’s syndrome-like sialoadenitis.J Autoimmun.2010;35:383-9Disclosure of Interests:None declared
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Ali, Amira Mohammed, Amin Omar Hendawy, Ohoud Ahmad, Haleama Al Sabbah, Linda Smail, and Hiroshi Kunugi. "The Arabic Version of the Cohen Perceived Stress Scale: Factorial Validity and Measurement Invariance." Brain Sciences 11, no. 4 (March 26, 2021): 419. http://dx.doi.org/10.3390/brainsci11040419.
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University students experience high levels of stress due to university transition, academic commitments, and financial matters. Higher stress perceptions along with limited coping resources endanger mental health for a considerable number of students and may ruin their performance. The current study evaluated the psychometric properties of the Cohen Perceived Stress Scale (10 items), PSS-10, in a sample of 379 female Emeriti students. Exploratory factor analysis resulted in two factors with eigenvalues of 3.88 and 1.19, which explained 60.6% of the variance. Confirmatory factor analysis revealed good model fits of two correlated factors (Comparative Fit Index (CFI) = 0.962, Tucker–Lewis Index (TLI) = 0.950, standardized root-mean-square residual (SRMR) = 0.0479, and root mean-square error of approximation (RMSEA) = 0.067). Internal consistency of the PSS-10 and its positive and negative subscales was acceptable (coefficient α = 0.67, 0.79, and 0.86, respectively). Multigroup analysis revealed that the PSS-10 holds invariance across different groups of age, marital status, and financial status (average monthly expenditure). Convergent and concurrent validity tests signify the importance of considering scores of subscales of the PSS-10 along with its total score.
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Adamson, Maheen M., Angela Phillips, Srija Seenivasan, Julian Martinez, Harlene Grewal, Xiaojian Kang, John Coetzee, et al. "International Prevalence and Correlates of Psychological Stress during the Global COVID-19 Pandemic." International Journal of Environmental Research and Public Health 17, no. 24 (December 10, 2020): 9248. http://dx.doi.org/10.3390/ijerph17249248.
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This study reports perceived stress and associated sociodemographic factors from an international sample of adults, during the COVID-19 pandemic. The Perceived Stress Scale (PSS-10) along with socio-demographic questions were conducted between 8 April 2020 and 11 May 2020. The survey was translated from English into five languages. Recruitment was conducted worldwide using social media. A total of 1685 survey responses were collected across 57 countries with eleven countries (≥30 responses/country) included in the sub-analyses. Overall, the mean PSS-10 score was 19.08 (SD = 7.17), reflecting moderate stress compared to previously reported norms. Female gender was associated with a higher PSS score (3.03, p < 0.05) as well as four-year degree holders (3.29, p < 0.05), while adults over 75 years (−7.46, p < 0.05) had lower PSS scores. Personal care composite score (including hours of sleep, exercise, and meditation) was associated with lower PSS scores (−0.39, p < 0.01). Increases in personal care and changes in work expectations were associated with lower PSS scores (−1.30 (p < 0.05) and −0.38 (p < 0.01), respectively). Lower total PSS scores were reported in Germany (−4.82, p < 0.01) compared to the global response sample mean. This information, collected during the initial period of global mitigation orders, provides insight into potential mental health risks and protective factors during crises.
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Anacleto, Cristiane Alves, Edson Pacheco Paladini, and Caroline Rodrigues Vaz. "Customer requirements for the continuous improvement of product-service system: a conceptual approach." Independent Journal of Management & Production 9, no. 2 (June 1, 2018): 526. http://dx.doi.org/10.14807/ijmp.v9i2.688.
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Identifying customer requirements is a strategic element for consolidating product-service systems (PSSs) in the market. However, literature on empirical studies has devoted relatively little attention to this topic. The purpose of the present work is to identify PSS customer requirements by analyzing empirical studies. Toward this goal, we present here a structured systematic literature review. This study systematically reviews 269 articles published until 2015 in the PSS field. About 10% of the publications reviewed describe empirical studies that identify PSS-customer requirements. After analyzing the content of these articles, we identify 37 requirements clustered around three criteria: (i) type of PSS, (ii) type of business transaction, and (iii) customer requirements that relate to product, service, or general aspects of PSS. The empirical studies investigated in this literature review focused on the business-to-business context. This study support PSS provider meet customer requirements. Then, they will be more successful in offering the PSS.
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Mahdy, Ahmed, Martin Stradner, Andreas Roessler, Bianca Brix, Angelika Lackner, Adam Salon, and Nandu Goswami. "A Pilot Study: Hypertension, Endothelial Dysfunction and Retinal Microvasculature in Rheumatic Autoimmune Diseases." Journal of Clinical Medicine 10, no. 18 (September 9, 2021): 4067. http://dx.doi.org/10.3390/jcm10184067.
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Background: The etiology of autoimmune rheumatic diseases is unknown. Endothelial dysfunction and premature atherosclerosis are commonly seen in these patients. Atherosclerosis is considered one of the main causes of cardiovascular diseases. Hypertension is considered the most important traditional cardiovascular risk. This case-control study aimed to investigate the relationship between autoimmune diseases and cardiovascular risk. Methods: This study was carried out in patients with rheumatoid arthritis, RA (n = 10), primary Sjögren syndrome, PSS (n = 10), and healthy controls (n = 10). Mean blood pressure (MBP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse wave velocity (PWV, an indicator of arterial stiffness) were assessed via a Vicorder device. Asymmetric dimethylarginine (ADMA) was measured via ELISA. Retinal photos were taken via a CR-2 retinal camera, and retinal microvasculature analysis was carried out. T-tests were conducted to compare the disease and control groups. ANOVA and ANOVA—ANCOVA were also used for the correction of covariates. Results: A high prevalence of hypertension was seen in RA (80% of cases) and PSS (40% of cases) compared to controls (only 20% of cases). Significant changes were seen in MBP (RA 101 ± 11 mmHg; PSS 93 ± 10 mm Hg vs. controls 88 ± 7 mmHg, p = 0.010), SBP (148 ± 16 mmHg in RA vs. 135 ± 16 mmHg in PSS vs. 128 ± 11 mmHg in control group; p = 0.007), DBP (77 ± 8 mmHg in RA, 72 ± 8 mmHg in PSS vs. 67 ± 6 mmHg in control; p = 0.010 in RA compared to the controls). Patients with PSS showed no significant difference as compared to controls (MBP: p = 0.240, SBP: p = 0.340, DBP: p = 0.190). Increased plasma ADMA was seen in RA (0.45 ± 0.069 ng/mL) and PSS (0.43 ± 0.060 ng/mL) patients as compared to controls (0.38 ± 0.059 ng/mL). ADMA in RA vs. control was statistically significant (p = 0.022). However, no differences were seen in ADMA in PSS vs. controls. PWV and retinal microvasculature did not differ across the three groups. Conclusions: The prevalence of hypertension in our cohort was very high. Similarly, signs of endothelial dysfunction were seen in autoimmune rheumatic diseases. As hypertension and endothelial dysfunction are important contributing risk factors for cardiovascular diseases, the association of hypertension and endothelial dysfunction should be monitored closely in autoimmune diseases.
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Nie, Yongqian, Xuanxi Leng, Yixue Jiang, Shigan Chai, Jinzhi Zhang, and Qichao Zou. "Influence of reactive POSS and DDP on thermal stability and flame retardance of UPR nanocomposites." e-Polymers 17, no. 6 (October 26, 2017): 463–70. http://dx.doi.org/10.1515/epoly-2016-0316.
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AbstractUnsaturated polyester resins (UPR) were prepared by the melt condensation method based on adipic acid, o-phthalic anhydride, maleic anhydride and ethylene glycol in the presence of PSS-(2,3-propanediol)propoxy-heptaisobutyl substituted (PSS-POSS) or/and 9 wt% [(6-oxide-6H-dibenz(c,e)(1,2)oxaphosphorin-6-yl)methyl]butanedioic (DDP). We synthesized UPR containing DDP (DDP-UPR) and UPR containing both DDP and PSS-POSS (DDP-PSS-POSS-UPR series). The chemical structures of the modified polyesters were characterized and confirmed by Fourier transform infrared (FTIR) and 31P nuclear magnetic resonance (31P NMR). The thermal stability and flammability behaviors of UPR were evaluated by thermogravimetric analysis (TGA) and limited oxygen index (LOI) and the vertical burning test. The morphology of residual char of UPR was shown by scanning electron microscopy (SEM). The results indicate that the incorporation of PSS-POSS has little influence on the thermal stability of DDP-UPR, but enhances the flame retardance of DDP-UPR, and when the PSS-POSS content reaches 10 wt%, the DDP-PSS-POSS-UPR has better flame retardance.
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Tozzi, Carol A., and Gary F. Merrill. "Differential effects of adenosine and verapamil on histamine vascular contractions." Canadian Journal of Physiology and Pharmacology 64, no. 6 (June 1, 1986): 679–82. http://dx.doi.org/10.1139/y86-112.
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The present study was undertaken to compare the effects of adenosine and verapamil on histamine-induced contractions in rabbit vascular smooth muscle. Ring segments of rabbit femoral artery were isometrically mounted and contractile responses to histamine (10−7 to 10−4 M) were recorded. Verapamil (10−5 to 10−4 M) and adenosine (10−5 to 10−4 M) produced significant (P < 0.05) shifts to the right of the histamine dose–response curve in normal physiological salt solution (PSS). Adenosine (10−4 M) had no effect on the contractile responses to histamine in calcium-deplete PSS but significantly (P < 0.01) increased the rate of relaxation (−dT/dt, 16.1 ± 2.3 mg/s before adenosine, 53.7 ± 7.0 mg/s during adenosine). In calcium-free PSS, verapamil (10−4 M) had no effects on histamine-induced contractions, nor did it affect the spontaneous rate of relaxation. These findings suggest that the relaxant responses to adenosine, like verapamil, are partially mediated through blockade of external calcium influx, while adenosine, unlike verapamil, appears to have an additional intracellular mode of action.
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Ashmawy, Almehizia, Youssef, El-Galil E. Amr, Al-Omar, and Kamel. "Novel Carbon/PEDOT/PSS-Based Screen-Printed Biosensors for Acetylcholine Neurotransmitter and Acetylcholinesterase Detection in Human Serum." Molecules 24, no. 8 (April 18, 2019): 1539. http://dx.doi.org/10.3390/molecules24081539.
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New reliable and robust potentiometric ion-selective electrodes were fabricated using poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) as the solid contact between the sensing membrane and electrical substrate for an acetylcholine (ACh) bioassay. A film of PEDOT/PSS was deposited on a solid carbon screen-printed platform made from ceramic substrate. The selective materials used in the ion-selective electrode (ISE) sensor membrane were acetylcholinium tetraphenylborate (ACh/TPB/PEDOT/PSS-ISE) (sensor I) and triacetyl-β-cyclodextrin (β-CD/PEDOT/PSS-ISE) (sensor II). The sensors revealed clear enhanced Nernstian response with a cationic slope 56.4 ± 0.6 and 55.3 ± 1.1 mV/decade toward (ACh+) ions over the dynamic linear range 1.0 × 10−6–1 × 10−3 and 2.0 × 10−6–1.0 × 10−3 M at pH 5 with limits of detection 2.0 × 10−7 and 3.2 × 10−7 M for sensors I and II, respectively. The selectivity behavior of both sensors was also tested and the sensors showed a significant high selectivity toward ACh+ over different common organic and inorganic cations. The stability of the potential response for the solid-contact (SC)/ISEs was evaluated using a chronopotentiometric method and compared with that of electrodes prepared without adding the solid-contact material (PEDOT/PSS). Enhanced accuracy, excellent repeatability, good reproducibility, potential stability, and high selectivity and sensitivity were introduced by these cost-effective sensors. The sensors were also used to measure the activity of acetylcholinesterase (AChE). A linear plot between the initial rate of the hydrolysis of ACh+ substrate and enzyme activity held 5.0 × 10−3–5.2 IU∙L−1 of AChE enzyme. Application to acetylcholine determination in human serum was done and the results were compared with the standard colorimetric method.
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Asri, Nurul Ain Najihah, Baharin Amir, Anis Syahirah Ramli, Muhd Fauzi Safian, Azlan Zakaria, Nur Aimi Jani, and Mohd Muzamir Mahat. "The effect of ethylene glycol post-treatment on the electrical conductivity of PEDOT: PSS thin films." Journal of Physics: Conference Series 2169, no. 1 (January 1, 2022): 012036. http://dx.doi.org/10.1088/1742-6596/2169/1/012036.
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Abstract The application of organic conducting polymers such as poly (3,4-ethylene dioxythiophene): poly (4-styrene sulfonate) (PEDOT: PSS) is vastly expanding for the development of advanced and flexible organic electronic devices, such as solar cells, light-emitting diodes, and organic electrochemical transistors (OECTs). Also, PEDOT: PSS can perfectly replace high-cost Indium tin oxide (ITO) thin films. In this study, PEDOT: PSS was synthesized via the chemical oxidative polymerization method. The film formation was carried out through a feasible drop-casting method onto a cleaned glass substrate. To further enhance the conductivity of pristine PEDOT: PSS, the PEDOT: PSS thin films were post-treated with different concentrations (3, 5, and 7% v/v) of ethylene glycol (EG). Based on the electrochemical impedance spectroscopy (EIS) analysis, it was revealed that the post-treated sample had a higher conductivity value compared to the untreated sample (2.48 × 10-4 S/cm), with the highest recorded conductivity value of 2.67 ×10-3 S/cm at 5% v/v of EG. This result corresponds to the previous study, which highlighted that the optimum concentration of EG is 5% v/v to achieve the optimum conductivity value for thin film application. Furthermore, the structural properties of the thin films were characterized using Fourier transform infrared (FTIR) spectroscopy to confirm the presence of PEDOT: PSS and EG in the samples.
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Herrala, Maria, Soile Turunen, Kati Hanhineva, Marko Lehtonen, Jopi J. W. Mikkonen, Hubertus Seitsalo, Reijo Lappalainen, et al. "Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome." Metabolites 11, no. 9 (September 3, 2021): 595. http://dx.doi.org/10.3390/metabo11090595.
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Saliva is a complex oral fluid, and plays a major role in oral health. Primary Sjögren’s syndrome (pSS), as an autoimmune disease that typically causes hyposalivation. In the present study, salivary metabolites were studied from stimulated saliva samples (n = 15) of female patients with pSS in a group treated with low-dose doxycycline (LDD), saliva samples (n = 10) of non-treated female patients with pSS, and saliva samples (n = 14) of healthy age-matched females as controls. Saliva samples were analyzed with liquid chromatography mass spectrometry (LC-MS) based on the non-targeted metabolomics method. The saliva metabolite profile differed between pSS patients and the healthy control (HC). In the pSS patients, the LDD treatment normalized saliva levels of several metabolites, including tyrosine glutamine dipeptide, phenylalanine isoleucine dipeptide, valine leucine dipeptide, phenylalanine, pantothenic acid (vitamin B5), urocanic acid, and salivary lipid cholesteryl palmitic acid (CE 16:0), to levels seen in the saliva samples of the HC. In conclusion, the data showed that pSS is associated with an altered saliva metabolite profile compared to the HC and that the LLD treatment normalized levels of several metabolites associated with dysbiosis of oral microbiota in pSS patients. The role of the saliva metabolome in pSS pathology needs to be further studied to clarify if saliva metabolite levels can be used to predict or monitor the progress and treatment of pSS.
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Sakao, Tomohiko, and Abhijna Neramballi. "A Product/Service System Design Schema: Application to Big Data Analytics." Sustainability 12, no. 8 (April 24, 2020): 3484. http://dx.doi.org/10.3390/su12083484.
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The challenge of environmental sustainability has required product/service systems (PSSs) to play a substantial role. New technologies such as big data analytics (BDA), which have high potential to improve or enable PSSs, are increasingly implemented in industry. However, research achieved in the past and research opportunities in the intersection of PSS design and BDA are unclear in the literature. Therefore, this article took an inter-disciplinary approach and aimed to pave the way forward for research and development in PSS design and show opportunities to improve PSS design and delivery using BDA. The research methods adopted were literature synthesis and systematic literature review. The synthesis of PSS design literature resulted in a schema consisting of 10 design steps for PSS conceptual design. The systematic review of BDA literature found 11 research works, including industrial applications, which were then mapped on to the PSS design schema. This revealed the achievement of applied research using BDA for some of the PSS design steps as well as opportunities of research for the others. The two inter-related areas of research, PSS design and BDA, were connected with each other more clearly, so that further research could be anchored and motivated with more specificity.
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Wang, Yukai, Shaoqi Chen, Jingyao Chen, Xuezhen Xie, Sini Gao, Chengpeng Zhang, Songxia Zhou, et al. "Germline genetic patterns underlying familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren’s syndrome highlight T cell-initiated autoimmunity." Annals of the Rheumatic Diseases 79, no. 2 (December 17, 2019): 268–75. http://dx.doi.org/10.1136/annrheumdis-2019-215533.
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ObjectivesFamilial aggregation of primary Sjögren’s syndrome (pSS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and co-aggregation of these autoimmune diseases (ADs) (also called familial autoimmunity) is well recognised. However, the genetic predisposition variants that explain this clustering remains poorly defined.MethodsWe used whole-exome sequencing on 31 families (9 pSS, 11 SLE, 6 RA and 5 mixed autoimmunity), followed by heterozygous filtering and cosegregation analysis of a family-focused approach to document rare variants predicted to be pathogenic by in silico analysis. Potential importance in immune-related processes, gene ontology, pathway enrichment and overlap analyses were performed to prioritise gene sets.ResultsA range from 1 to 50 rare possible pathogenic variants, including 39 variants in immune-related genes across SLE, RA and pSS families, were identified. Among this gene set, regulation of T cell activation (p=4.06×10−7) and T cell receptor (TCR) signalling pathway (p=1.73×10−6) were particularly concentrated, including PTPRC (CD45), LCK, LAT–SLP76 complex genes (THEMIS, LAT, ITK, TEC, TESPA1, PLCL1), DGKD, PRKD1, PAK2 and NFAT5, shared across 14 SLE, RA and pSS families. TCR-interactive genes P2RX7, LAG3, PTPN3 and LAX1 were also detected. Overlap analysis demonstrated that the antiviral immunity gene DUS2 variant cosegregated with SLE, RA and pSS phenotypes in an extended family, that variants in the TCR-pathway genes CD45, LCK and PRKD1 occurred independently in three mixed autoimmunity families, and that variants in CD36 and VWA8 occurred in both RA-pSS and SLE-pSS families.ConclusionsOur preliminary results define common genetic characteristics linked to familial pSS, SLE and RA and highlight rare genetic variations in TCR signalling pathway genes which might provide innovative molecular targets for therapeutic interventions for those three ADs.
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Dassouki, T., F. B. Benatti, A. J. Pinto, H. Roschel, F. R. Lima, K. Augusto, S. Pasoto, R. M. R. Pereira, B. Gualano, and A. L. de Sá Pinto. "Objectively measured physical activity and its influence on physical capacity and clinical parameters in patients with primary Sjögren’s syndrome." Lupus 26, no. 7 (October 26, 2016): 690–97. http://dx.doi.org/10.1177/0961203316674819.
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Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren’s syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-sectional study, 29 women with pSS were objectively assessed for habitual physical activity levels (using accelerometry) and compared with 20 healthy women (CTRL) frequency-matched for physical activity levels, age, body mass index, and body fat percentage with regard to physical capacity and function, fatigue, depression, pain, and health-related quality of life. Results pSS showed 8.5 min/day of moderate-to-vigorous physical activity (MVPA) when only MVPA accumulated in bouts ≥ 10 min was considered; when considering total MVPA (including bouts < 10 min), average levels were 26.3 min/day, with 62% of pSS patients achieving the recommendation (≥ 21.4 min/day). Moreover, pSS showed lower VO2peak, lower muscle strength and function, higher fatigue, and poorer health-related quality of life when compared with CTRL ( p < 0.05). These differences (except for aerobic capacity) were sustained even when only individuals achieving the minimum of 21.4 min/day of total MVPA in both groups were compared. Finally, MVPA time was significantly correlated with aerobic conditioning, whereas total counts and sedentary time were associated with lower-body muscle strength and the bodily-pain domain of SF-36 in patients with pSS. Conclusion When compared to physical activity-matched healthy controls, pSS patients showed reduced physical capacity and function, increased fatigue and pain, and reduced health-related quality of life. Except for aerobic conditioning, these differences were sustained when only more physically active participants were compared, indicating that minimum recommended levels of physical activity for the general population may not be sufficient to counteract pSS comorbidities.
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Kurniawan, Andre, Arie Utariani, Hamzah, and Nalini. "Hubungan Antara Tingkat Stres dan Kadar Kortisol Saliva dan Faktor Penyebab Stres Residen Anestesiologi dan Terapi Intensif pada Era Pandemi Covid-19." Jurnal Syntax Transformation 2, no. 2 (February 23, 2021): 147–56. http://dx.doi.org/10.46799/jst.v2i2.229.
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Pandemi COVID-19 berdampak pada proses pendidikan residen anestesi yang merupakan salah satu garda depan pelayanan medis. Situasi seperti ini akan menambah stres dan beban mental yang berpotensi menurunkan imunitas tubuh dan kualitas pelayanan. Kortisol saliva merupakan biomarker stres yang reliabel dalam mengukur tingkat stres karena bersirkulasi akut dalam tubuh. Penelitian ini bertujuan menganalisis hubungan antara kadar kortisol saliva dengan tingkat stres residen anestesiologi dan terapi intensif di era pandemi COVID-19 yang diukur menggunakan perceived stress scale (PSS-10). Metode penelitian adalah observasional analitik dilakukan pada 40 residen anestesiologi usia 28-39 tahun dan dalam masa putaran stase ruang isolasi khusus (RIK) dan ruang resusitasi (RES) yang menangani pasien terpapar COVID-19 di RSUD Dr. Soetomo Surabaya pada bulan Agustus-September 2020. Hasil perhitungan statistik dengan Uji Spearman, hubungan antara PSS-10 dan kadar kortisol, tingkat stres ringan (25% vs 67,5%) dan stres sedang (75% vs 37,5%) secara statistik bermakna (p=0,005; r=0,388) Simpulan: Tingkat stres residen anestesiologi berdasarkan PSS-10 berkorelasi linear terhadap kadar kortisol saliva di era pandemi COVID-19. Faktor stres paling dominan yakni perasaan kesal akibat sesuatu terjadi secara mendadak dan gugup jika terjadi hal diluar kendali. PSS-10 layak dipertimbangkan sebagai modalitas alat ukur dalam menilai tingkat stres residen anestesi di era pandemi COVID-19.
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Leombruni, Paolo, Alessio Corradi, Giuseppina Lo Moro, Anna Acampora, Antonella Agodi, Daniele Celotto, Maria Chironna, et al. "Stress in Medical Students: PRIMES, an Italian, Multicenter Cross-Sectional Study." International Journal of Environmental Research and Public Health 19, no. 9 (April 20, 2022): 5010. http://dx.doi.org/10.3390/ijerph19095010.
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Medical students (MSs) are healthcare workers and must also cope with education-related stressors. This study aims to assess factors associated with perceived stress in Italian MSs. A cross-sectional study was conducted in 12 Italian medical schools (MSCs) in November 2018. A questionnaire assessed socio-demographic characteristics, habits, opinions about MSC, and concerns about the future. Stress was assessed with the PSS-10. Descriptive and univariable tests were performed. A linear model was fitted to find associations of the PSS-10 score with characteristics. There were 2513 collected questionnaires. Median PSS-10 score was 18 (IQR 11). Median age was 22 (IQR 4) and 61% of the sample was female. Female gender, being part of a sexual minority, poor financial situation, competitive atmosphere, having hobbies, resting, and sleeping hindered by MSC were characteristics associated with higher PSS-10 scores. Current relationship, good family relationship, and no concerns about the future were protective factors. Being part of sexual minorities had greater effects in students not living away from home, while in the other group it was not having satisfying friendships. Medical students suffer higher levels of stress than the general population, and many MSC stressors are associated. Living away from home modifies risk and protective factors, offering the possibility to tailor group-specific interventions.
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Algarvio, Susana, Isabel Leal, and João Maroco. "Parental Stress Scale: Validation study with a Portuguese population of parents of children from 3 to 10 years old." Journal of Child Health Care 22, no. 4 (March 14, 2018): 563–76. http://dx.doi.org/10.1177/1367493518764337.
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The aim of this study was to validate the Parental Stress Scale (PSS) for Portuguese parents and to further investigate the scale’s criterion-related validity. A two-stage stratified sample of the Portuguese population of parents, with children attending public preschools and primary schools, was obtained, totalizing 3842 parents of children between 3 and 10 years old. Parents completed a Parental Concerns Scale and the Portuguese version of the PSS. Results support the four-factor structure of the Portuguese version of the PSS. Higher levels of parental stress were reported by parents of boys, with lower educational levels; older, divorced or single parents; unemployed mothers; and with a higher number of children. Parental concerns and parental stress’ comparative study reported very low correlations between the two constructs. This study supported evidence for the PSS’ validity with a stratified sample of Portuguese parents of children between 3 and 10 years old. Moreover, our findings reported the scale’s divergent validity with a Parental Concerns Scale. These results point to the importance of assessing both dimensions in family practice.
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Lin, Chun-Yu, Hung-An Chen, Tsang-Wei Chang, Tsai-Ching Hsu, Chung-Yuan Hsu, and Yu-Jih Su. "Association of primary Sjögren’s syndrome with incident heart failure: a secondary analysis of health claims data in Taiwan." Therapeutic Advances in Chronic Disease 13 (January 2022): 204062232210780. http://dx.doi.org/10.1177/20406223221078083.
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Objective: Mounting evidence has demonstrated that various chronic inflammatory diseases are associated with incident heart failure (HF). However, there is scarce evidence about the association between primary Sjögren’s syndrome (pSS) and HF. We aimed to explore this association using a nationwide database in Taiwan. Methods: We selected patients with incident pSS and no history of HF. Using propensity score matching based on age, sex, cohort entry time, comorbidities, and concomitant medications, cohorts of patients with and without pSS (as controls) were created in a 1:1 ratio and the groups were compared. The cumulative incidence of HF was calculated using Kaplan–Meier estimation. Cox proportional hazard regression analysis was used to measure the hazard ratio (HR) of HF-related hospitalization for the pSS cohort compared with the comparison group. Results: A total of 16,466 pairs of patients with pSS and those without pSS were identified. The cumulative incidence of HF-related hospitalization at 3, 5, and 10 years in patients with pSS was 1.05%, 1.89%, and 4.33%, respectively. The risk of HF-related hospitalization was not higher in patients with pSS than in the general population (HR: 0.98, 95% confidence interval [CI]: 0.84–1.14). There was no difference in survival probability after the first episode of HF-related hospitalization between pSS and non-pSS groups. Conclusion: Our results suggest that distinct inflammatory spectrums in each chronic inflammatory disease might have differential impacts on cardiac function and subsequent risk of HF. Future studies are needed to elucidate the complex and diverse mechanisms of HF in various chronic autoimmune diseases.
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Wang, Wenjun, and Longjiang Yu. "Preparation, Characterization, and Biotransformation of the Inclusion Complex of Phytosterols and Hydroxypropyl-β- cyclodextrin by Mycobacterium neoaurum." Zeitschrift für Naturforschung C 66, no. 5-6 (June 1, 2011): 277–82. http://dx.doi.org/10.1515/znc-2011-5-611.
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The inclusion complex of hydroxypropyl-β-cyclodextrin (HBβCD) and phytosterols (PSs) was prepared and characterized by thermogravimetric analysis (TGA) and infrared (IR) spectroscopy. Biotransformation of the inclusion complex of phytosterols and hydroxypropyl- β-cyclodextrin (PSs-HBβCD) by Mycobacterium neoaurum to 1,4-androstadiene-3,17-dione and 4-androstene-3,17-dione [AD(D)] was studied. The TGA and IR results indicated that the thermal stability of PSs was improved in the complex with HBβCD. Biotransformation improved the solubility of PSs in the aqueous medium a lot because the AD(D) production was increased remarkably compared with the control, but growth of the bacteria was inhibited in the presence of HBβCD. The optimal inclusion ratio, ultrasonic treating time, dosage, and time of addition of PSs-HBβCD complexe were found to be 2:1, 10 min, 1.5 g/30 ml medium, and 48 h after incubation, respectively. This inclusion technique not only increased the availability of the substrates for the microorganisms, but also the capability of these microorganisms to produce AD(D) from PSs.
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Ahmad Ruzaidi, Dania Adila, Mohd Muzamir Mahat, Zarif Mohamed Sofian, Nikman Adli Nor Hashim, Hazwanee Osman, Mohd Azizi Nawawi, Rosmamuhamadani Ramli, et al. "Synthesis and Characterization of Porous, Electro-Conductive Chitosan–Gelatin–Agar-Based PEDOT: PSS Scaffolds for Potential Use in Tissue Engineering." Polymers 13, no. 17 (August 28, 2021): 2901. http://dx.doi.org/10.3390/polym13172901.
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Herein we report the synthesis and characterization of electro-conductive chitosan–gelatin–agar (Cs-Gel-Agar) based PEDOT: PSS hydrogels for tissue engineering. Cs-Gel-Agar porous hydrogels with 0–2.0% (v/v) PEDOT: PSS were fabricated using a thermal reverse casting method where low melting agarose served as the pore template. Sample characterizations were performed by means of scanning electron microscopy (SEM), attenuated total reflectance–Fourier transform infrared spectroscopy (ATR–FTIR), X-ray diffraction analysis (XRD) and electrochemical impedance spectroscopy (EIS). Our results showed enhanced electrical conductivity of the cs-gel-agar hydrogels when mixed with DMSO-doped PEDOT: PSS wherein the optimum mixing ratio was observed at 1% (v/v) with a conductivity value of 3.35 × 10−4 S cm−1. However, increasing the PEDOT: PSS content up to 1.5 % (v/v) resulted in reduced conductivity to 3.28 × 10−4 S cm−1. We conducted in vitro stability tests on the porous hydrogels using phosphate-buffered saline (PBS) solution and investigated the hydrogels’ performances through physical observations and ATR–FTIR characterization. The present study provides promising preliminary data on the potential use of Cs-Gel-Agar-based PEDOT: PSS hydrogel for tissue engineering, and these, hence, warrant further investigation to assess their capability as biocompatible scaffolds.
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Remor, Eduardo. "Psychometric Properties of a European Spanish Version of the Perceived Stress Scale (PSS)." Spanish Journal of Psychology 9, no. 1 (May 2006): 86–93. http://dx.doi.org/10.1017/s1138741600006004.
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This paper presents evidence from a heterogeneous sample of 440 Spanish adults, for the reliability and validity of a European Spanish version of the Perceived Stress Scale (PSS), designed to measure the degree to which situations in one's life are appraised as stressful. The European Spanish version PSS (14-item) demonstrated adequate reliability (internal consistency, α = .81, and test-retest, r = .73), validity (concurrent), and sensitivity. Additional data indicate adequate reliability (α = .82, test-retest, r = .77), validity, and sensitivity of a 10-item short version of the PSS.
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Intrieri, Robert, and Paige Goodwin. "Confirmatory Factor Analysis of the Perceived Stress Scale-10 Across Age Groups." Innovation in Aging 4, Supplement_1 (December 1, 2020): 304–5. http://dx.doi.org/10.1093/geroni/igaa057.975.
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Abstract The Perceived Stress Scale-10 (PSS; Cohen et al, 1983) was developed to measure subjective elements of stress. Most measures focus on objective characteristics of stress (e. g., frequency of occurrence) and specific situations that produce stress (e. g., divorce) but ignore the cognitive appraisal associated with stressful stimuli. The PSS-10 assesses the interplay between stressor and appraisal-mediated coping ability. Factor analytic studies provide support for two factors: perceived helplessness and perceived self-efficacy (see Roberti et al. 2006). The current study presents data from 591 people across three groups: 221 young adults (mean age 19.31, SD = 1.21), 283 middle-age adults (mean age 48.27, SD = 5.14), and 109 older adults (mean age 72.95, SD = 7.22). An ordinal confirmatory factor analysis (CFA) using robust weighted least squares (WLSMV) evaluated invariance across age groups. Results showed CFI/TLI values of .964/.953, 965/.960, and .964/.969 for Configural (CI), Metric (MI), and Scalar (SI) models. The RMSEA for CI, MI, and SI models was .086, .081, and .071. Based upon recommendations of Cheung and Rensvold (2002), Sass (2011), and Chen (2007), a cutoff of ΔCFI ≥ 0.01 was established as evidence of invariance. The ΔCFI between CI and MI models was < .01 so analysis continued with the SI test. Once again, ΔCFI between MI and SI models was < 0.01 which did not justify rejection of the null hypothesis. Based on these analyses, PSS-10 scores are valid across multiple age groups. Further, results support the multidimensional nature of the PSS-10.
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Tiwari, Vikash K., Vinay Singh, Devesh Kumar, Mahim Mittal, and A. B. Asthana. "Is yoga an effective modality of stress reduction within medical population; a qualitative study within MBBS students of BRD medical college, Gorakhpur." International Journal of Research in Medical Sciences 6, no. 2 (January 24, 2018): 581. http://dx.doi.org/10.18203/2320-6012.ijrms20180302.
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Background: Stress is very common in medical professionals. Stress begins in the first year of medical school and increases with subsequent years of medical life. Stress decreases overall performance and had a multitude of health-related adverse effect. Yoga has been tried as a stress reduction technique in different populations. In present study yoga was performed in the 1st year MBBS students and impact on stress reduction was studied using PSS-10 stress scale.Methods: Study groups, yoga and control contained 26 and 27 subjects respectively. The yoga group practiced selected yogic asana, pranayama, and yoga nidra 1hour daily 6days a week for 3months. Control group kept in touch and allowed their usual activity as before. The PSS-10 scale used to measure the level of stress in both groups pre and post study.Results: There was a highly significant reduction in the PSS-10 Score (stress level) in the yoga group (P Value <0.0001) but there was no significant change in the PSS-10 Score of control group (P Value = 0.2930).Conclusions: Yoga is an effective modality of stress reduction technique in 1st year medical students. Therefore, yoga should be introduced as a part of the curricula in the first year of medical school. This may be taken as the 1st step in implantation of healthy lifestyle in future health care providers.
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Stergiou, Ioanna E., Loukas Chatzis, Asimina Papanikolaou, Stavroula Giannouli, Athanasios G. Tzioufas, Michael Voulgarelis, and Efstathia K. Kapsogeorgou. "Akt Signaling Pathway Is Activated in the Minor Salivary Glands of Patients with Primary Sjögren’s Syndrome." International Journal of Molecular Sciences 22, no. 24 (December 14, 2021): 13441. http://dx.doi.org/10.3390/ijms222413441.
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Primary Sjögren’s syndrome (pSS) is an autoimmune exocrinopathy of mainly the salivary and lacrimal glands associated with high prevalence of lymphoma. Akt is a phosphoinositide-dependent serine/threonine kinase, controlling numerous pathological processes, including oncogenesis and autoimmunity. Herein, we sought to examine its implication in pSS pathogenesis and related lymphomagenesis. The expression of the entire and activated forms of Akt (partially and fully activated: phosphorylated at threonine-308 (T308) and serine-473 (S473), respectively), and two of its substrates, the proline-rich Akt-substrate of 40 kDa (PRAS40) and FoxO1 transcription factor has been immunohistochemically examined in minor salivary glands (MSG) of pSS patients (n = 29; including 9 with pSS-associated lymphoma) and sicca-complaining controls (sicca-controls; n = 10). The entire and phosphorylated Akt, PRAS40, and FoxO1 molecules were strongly, uniformly expressed in the MSG epithelia and infiltrating mononuclear cells of pSS patients, but not sicca-controls. Morphometric analysis revealed that the staining intensity of the fully activated phospho-Akt-S473 in pSS patients (with or without lymphoma) was significantly higher than sicca-controls. Akt pathway activation was independent from the extent or proximity of infiltrates, as well as other disease features, including lymphoma. Our findings support that the Akt pathway is specifically activated in MSGs of pSS patients, revealing novel therapeutic targets.
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Márquez, José Jesús, José María López-Gullón, Cristina Menescardi, and Coral Falcó. "Comparison between the KPNP and Daedo Protection Scoring Systems through a Technical-Tactical Analysis of Elite Taekwondo Athletes." Sustainability 14, no. 4 (February 12, 2022): 2111. http://dx.doi.org/10.3390/su14042111.
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Background: In the last two decades, the use of technology has been incorporated into taekwondo, changing the rules of the sport to employ a more objective scoring system. The current electronic Protection Scoring Systems (PSS) include sensors that register the number and power of the hits scored, but these may interfere with athlete’s techniques and tactics. This study aimed to analyze the technical-tactical differences in elite taekwondoists using two different PSS. Methods: We systematically observed 112 combats involving 224 athletes, and their actions were registered and analyzed using contingency tables. Results: Eight hundred twenty-seven effective actions were tagged, and differences were found in the types of kicks performed using different PSS. For the total sample, there were differences between PSS in technical actions (X2 = 36.08(10); p < 0.01; V = 0.21), tactical actions (X2 = 10.73(3); p < 0.05; V = 0.11), and hitting side (X2 = 30.97(1); p < 0.01; V = 0.19). In men, the differences in techniques and tactics between different PSS were found in technical actions (X2 = 27.15(10); p < 0.01; V = 0.25), guard position (X2 = 14.94(1); p < 0.01; V = 0.18), and hitting side (X2 = 11.07(1); p < 0.01; V = 0.16), while in women, significant differences were found in technical actions (X2 = 37.03(8); p < 0.01; V = 0.32), tactical actions (X2 = 24.45(3); p < 0.01; V = 0.26), guard position (X2 = 3.95(1); p < 0.05; V = 0.10), hitting side (X2 = 19.27(1); p < 0.01; V = 0.23), and laterality (X2 = 16.32(3); p < 0.01; V = 0.21). Conclusions: The present study evidenced a difference in the technical-tactical behavior of elite taekwondoists as a result of the PSS used in combat, with more marked differences in female athletes. These findings also suggest the need to adapt and review the PSS to effectively score in the same way.
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Silva, Brenda Fernanda Pereira da, Laís Santos-Vitti, and André Faro. "Kessler Psychological Distress Scale: Internal Structure and Relation to Other Variables." Psico-USF 26, no. 1 (January 2021): 91–101. http://dx.doi.org/10.1590/1413-82712021260108.
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Abstract This study aimed to present validity evidence based on internal structure of the Kessler Scale of Psychological Distress (K10), to show its relations with the Perceived Stress Scale (PSS-10), and to present a social distribution of distress in the present sample. Participated in the study 717 residents of Aracaju, State of Sergipe, by means of household data collection. A sociodemographic questionnaire, K10, and PSS-10 were used as instruments. Exploratory Factor Analysis was performed using the Factor software, which indicated the scale unidimensionality, explaining 69.9% of the variance. Cronbach’s alpha was 0.93, and the model adjustment indices were satisfactory. A positive and statistically significant association between K10 and PSS-10 was observed. Regarding the social distribution, the levels of distress were higher in women, patients with chronic diseases, users of controlled drugs, and unemployed participants. It was concluded that K10 presented robust psychometric properties for the detection of distress in general population.
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WENG, MENG-YU, YU-TUNG HUANG, MING-FEI LIU, and TSUNG-HSUEH LU. "Incidence and Mortality of Treated Primary Sjögren’s Syndrome in Taiwan: A Population-based Study." Journal of Rheumatology 38, no. 4 (January 15, 2011): 706–8. http://dx.doi.org/10.3899/jrheum.100883.
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Objective.To estimate the incidence and mortality of treated primary Sjögren’s syndrome (pSS) by sex and age group in Taiwan.Methods.We used claims data of the Bureau of National Health Insurance (NHI) of Taiwan from 2005 to 2007 for analysis. According to the NHI, pSS is classified as one of the financially catastrophic illnesses and patients with pSS could be exempted from copayment of all medical costs. To obtain a catastrophic illness certificate (CIC) for pSS, patients are required to meet the criteria of the American-European Consensus Group for pSS, and are reviewed by a committee. Patients approved for receipt of a CIC for pSS for the first time were defined as incident cases of treated pSS.Results.A total of 3352 incident cases occurred between 2005 and 2007. The estimated mean annual incidence was 6.0 per 100,000 inhabitants (95% CI 5.8–6.2) for both sexes, 11.0 (95% CI 10.6–11.4) for women and 1.1 (95% CI 1.0–1.2) for men, with a female/male ratio of 9.9 (95% CI 8.8–11.1). Incidence increased with age, peaking at age 55–64 years in women and 65–74 years in men. The mortality rate was 33.4 per 1000 case person-years for men and 11.4 for women, with a male/female rate ratio of 2.9 (95% CI 1.7–5.3).Conclusion.The incidence of treated pSS in women is 10 times that in men. Nevertheless, pSS mortality in men is 3 times that in women.
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Ratka, Christoph, Paul Weigl, Dirk Henrich, Felix Koch, Markus Schlee, and Holger Zipprich. "The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces." Journal of Clinical Medicine 8, no. 9 (September 6, 2019): 1397. http://dx.doi.org/10.3390/jcm8091397.
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Purpose: Bacterial biofilms are a major problem in the treatment of infected dental and orthopedic implants. The purpose of this study is to investigate the cleaning effect of an electrolytic approach (EC) compared to a powder-spray system (PSS) on titanium surfaces. Materials and Methods: The tested implants (different surfaces and alloys) were collated into six groups and treated ether with EC or PSS. After a mature biofilm was established, the implants were treated, immersed in a nutritional solution, and streaked on Columbia agar. Colony-forming units (CFUs) were counted after breeding and testing (EC), and control (PSS) groups were compared using a paired sample t-test. Results: No bacterial growth was observed in the EC groups. After thinning to 1:1,000,000, 258.1 ± 19.9 (group 2), 264.4 ± 36.5 (group 4), and 245.3 ± 40.7 (group 6) CFUs could be counted in the PSS groups. The difference between the electrolytic approach (test groups 1, 3, and 5) and PSS (control groups 2, 4, and 6) was statistically extremely significant (p-value < 2.2 × 10−16). Conclusion: Only EC inactivated the bacterial biofilm, and PSS left reproducible bacteria behind. Within the limits of this in vitro test, clinical relevance could be demonstrated.
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Day, R., SM Bradberry, EA Sandilands, SHL Thomas, JP Thompson, and JA Vale. "Features reported after exposure to automatic dishwashing rinse aids." Human & Experimental Toxicology 39, no. 6 (January 24, 2020): 828–33. http://dx.doi.org/10.1177/0960327120901580.
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Introduction: Automatic dishwashing rinse aids are drying aids which contain non-ionic surfactants, usually ethoxylated alcohols, typically at concentrations of ≤30%. Objective: To assess the reported toxicity of rinse aids. Methods: Telephone enquiries to the UK National Poisons Information Service were analysed from January 2008 to June 2019. Results: Ingestion: Ingestion was involved in 976 cases and produced gastrointestinal features, coughing and central nervous system depression, particularly in young children. In those in whom the amount ingested was known, the majority (56%) of children <18 years and of adults (57%) ingested <50 mL of rinse aid. Although moderate or severe exposures (Poisoning Severity Score (PSS) ≥ 2) were uncommon, they occurred significantly ( p < 0.0008) more often in adults (9.0%) than in children (1.8%); however, three of the four adults with PSS ≥ 2 co-ingested other substances. Eye exposure: Ocular exposure was reported in 35 cases, of whom 29 developed features. Eye irritation ( n = 10, 28.6%) and eye pain ( n = 10, 28.6%) were reported most commonly, and three patients (8.6%) developed corneal abrasions (PSS 2). Dermal exposure: Thirty-four patients were exposed dermally, and six (17.6%) reported features, including rash, numbness, pruritus and burns (PSS 1). Conclusions: Overall, clinical features developed in 47% of patients exposed to rinse aids, but more severe features (PSS ≥ 2) were rare (<3%) following exposure by any route.
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Lauridsen, Line Skjødt, Morten Vejs Willert, Anita Eskildsen, and David Høyrup Christiansen. "Cross-cultural adaptation and validation of the Danish 10-item Connor-Davidson Resilience Scale among hospital staff." Scandinavian Journal of Public Health 45, no. 6 (July 14, 2017): 654–57. http://dx.doi.org/10.1177/1403494817721056.
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Objectives: The 10-item Connor-Davidson Resilience Scale (CD-RISC 10) is a brief instrument measuring resilience in adults. The scale has shown sound psychometric properties in different populations and cultures. Our objectives were to cross-culturally adapt the CD-RISC 10 into Danish and to establish the psychometric properties of the Danish version in terms of internal consistency, construct validity and longitudinal validity. Methods: The CD-RISC 10 was translated using established guidelines. Employees ( N=272) at hospitals in the Central Denmark Region completed questionnaires at baseline and three months follow-up. Questionnaires included the translated Danish version of the CD-RISC 10 and the 10-item Perceived Stress Scale (PSS-10). Internal consistency was assessed by Cronbach’s alpha and construct and longitudinal validity by correlating CD-RISC 10 and PSS-10 baseline scores and change scores from baseline to follow-up. Results: The Danish CD-RISC 10 provides acceptable internal consistency (Cronbach’s alpha = 0.87). Analysis of construct validity revealed a negative correlation with the PSS-10 at baseline ( r=−.63 [95%CI: −.70; −.55], p<.0001). Analysis of longitudinal validity similarly demonstrated a negative correlation on change scores from baseline to follow-up ( r=−.51 [95%CI: −.62; −.39], p<.0001). Conclusions: The scale has acceptable psychometric properties as an instrument for measuring resilience in a Danish-speaking population.
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Wesselink, Amelia K., Elizabeth E. Hatch, Kenneth J. Rothman, Jennifer L. Weuve, Ann Aschengrau, Rebecca J. Song, and Lauren A. Wise. "Perceived Stress and Fecundability: A Preconception Cohort Study of North American Couples." American Journal of Epidemiology 187, no. 12 (August 22, 2018): 2662–71. http://dx.doi.org/10.1093/aje/kwy186.
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Abstract While some epidemiologic studies support the hypothesis that stress can adversely affect fertility, few prospective studies have assessed the association in couples from the general population. We used data from Pregnancy Study Online, a web-based preconception cohort study of pregnancy planners from the United States and Canada (2013–2018), to examine the association between women’s and men’s perceived stress levels prior to conception and fecundability. Women (aged 21–45 years) and their male partners (aged ≥21 years) who were attempting conception without fertility treatment were eligible. We measured perceived stress using the 10-item Perceived Stress Scale (PSS). We ascertained pregnancy information using bimonthly follow-up questionnaires of female participants. We followed 4,769 couples until self-reported pregnancy, initiation of fertility treatment, loss to follow-up, or 12 menstrual cycles of attempt time, whichever came first. We used proportional probabilities regression models to estimate fecundability ratios and 95% confidence intervals, adjusting for potential confounders. Higher PSS scores among the women were associated with slight reductions in fecundability (comparing PSS scores of ≥25 vs. <10, fecundability ratio = 0.87, 95% confidence interval: 0.74, 1.02). PSS scores among the men were not substantially associated with fecundability.
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Bilichenko, T. N. "Diagnosis and treatment lung damage in systemic scleroderma." Clinical Medicine (Russian Journal) 98, no. 3 (July 16, 2020): 185–96. http://dx.doi.org/10.30629/0023-2149-2020-98-3-185-196.
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The progressing system sclerosis (PSS), M34.0 according to IСД-10 — an autoimmune disease with characteristic spastic vascular reactions as Reynaud’s syndrome and obliterating endarteritis with ischemic violations at which the specific frustration which are followed by activation of a fibrosis and excess adjournment of collagen in fabrics develop. The progressing current of PSS leads to development of irreversible fibrous changes of skin, the musculoskeletal device, internals (lungs, heart, a digestive tract, kidneys), to malfunction of bodies, an disability of patients with the general bad forecast of a disease. Thanks to modern therapy severe damage of kidneys, meets at PSS more rare and changes in lungs in a clinical picture come to the forefront. Early diagnostics of PSS and the differentiated approach to treatment of a disease can change the course and prognosis of the disease considerably.
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Dias, Juliana Chioda Ribeiro, Wanderson Roberto Silva, João Maroco, and Juliana Alvares Duarte Bonini Campos. "Perceived Stress Scale Applied to College Students: Validation Study." Psychology, Community & Health 4, no. 1 (March 31, 2015): 1–13. http://dx.doi.org/10.5964/pch.v4i1.90.
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ObjetivoApresentar uma versão em português (pós-acordo ortográfico) da Escala de Estresse Percebido (PSS-14), e estimar sua validade e confiabilidade em universitárias brasileiras.MétodoRealizaram-se validações de face e conteúdo. Realizou-se análise fatorial confirmatória (n = 1081) e utilizando-se como índices de ajustamento a razão qui-quadrado por graus de liberdade (χ²/gl), Comparative Fit Index (CFI), Normed of Fit Index (NFI) e o Root Mean Square Error of Approximation (RMSEA). Avaliou-se a estabilidade do melhor modelo em amostras independentes por análise multigrupos e a invariância pela diferença do qui-quadrado (Δχ²) para os pesos fatoriais (λ), Covariância entre fatores (Cov) e Resíduos (Res). Estimou-se a validade convergente pela Variância Extraída Média (VEM) e Confiabilidade Composta (CC). As validades concorrente e divergente da PSS foram estimadas por análise correlacional de Pearson (r) com a Weight Concerns Scale e o Inventário de Burnout de Maslach, respetivamente. A consistência interna foi estimada pelo Coeficiente alfa de Cronbach padronizado (α).ResultadosA versão de 10 itens (PSS-10) apresentou melhor ajustamento à amostra (χ²/gl = 10,69; CFI = 0,90; GFI = 0,93; RMSEA = 0,09). A validade convergente esteve abaixo do recomendado (VEM = 0,34; CC = 0,84). A consistência interna (α = 0,83) foi adequada. A estrutura foi estável nas subamostras independentes. As validades concorrente e divergente foram adequadas.ConclusãoA PSS-10 apresentou adequada validade, confiabilidade e estabilidade em amostras independentes de estudantes universitárias.
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Oshio, Takashi, Hiromi Kimura, Toshimi Nishizaki, and Takashi Omori. "Association between the use of social networking sites, perceived social support, and life satisfaction: Evidence from a population-based survey in Japan." PLOS ONE 15, no. 12 (December 18, 2020): e0244199. http://dx.doi.org/10.1371/journal.pone.0244199.
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This study examined the association between the use of social networking sites (SNS), perceived social support (PSS), and life satisfaction (LS), focusing on the mediating effect of PSS on the association between SNS use and LS. To this end, we used data (N = 15,574) obtained from a population-based, nationwide internet survey conducted in Japan. First, we confirmed that the number of SNS friends was positively associated with life satisfaction for all age groups: young (15–29 years), middle-aged (30–59 years), and old (60–86 years). However, the association was mixed if there were 100 or more SNS friends. Second, our structural equation modeling analysis underscored the mediating effect of PSS on the association between the number of SNS friends and LS for all age groups. Specifically, PSS mediated 36.5% (standard error [SE]: 8.6%), 39.8% (SE: 6.3%), and 40.3% (SE: 11.4%) of the association for the young, middle-aged, and old groups, respectively, if we defined SNS use as having 10 or more SNS friends. The mediating effect of PSS consistently contributed to the positive association between SNS use and LS regardless of the number of SNS friends, suggesting that SNS use has the potential to enhance subjective well-being via its positive impact on PSS.
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Wang, Sen, Han Shen, Bing Bai, Jia Wu, and Junjun Wang. "Increased CD4+CD8+ Double-Positive T Cell in Patients with Primary Sjögren’s Syndrome Correlated with Disease Activity." Journal of Immunology Research 2021 (May 14, 2021): 1–9. http://dx.doi.org/10.1155/2021/6658324.
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Primary Sjogren’s syndrome (pSS) is an autoimmune disease that invades lacrimal glands, salivary glands, and other exocrine glands, but its pathogenic mechanism is still unclear. CD4+CD8+ double-positive T (DPT) cells have been discovered in recent years to play an important role in autoimmune diseases and viral infections, but the frequency and significance of DPT in primary Sjogren’s syndrome are still unclear. This study detected the frequency of DPT in the peripheral blood of patients with pSS and detected the clinical indicators and cytokines in patients. We then analyzed the correlation between DPT and clinical indicators, cytokines, and disease activity scores. The results showed that the peripheral DPT frequency of pSS patients was significantly higher than that of healthy controls. The peripheral DPT frequency was negatively correlated with ESR, IgA, and IgG, and peripheral DPT frequency was positively correlated with anti-inflammatory cytokine IL-10. Analysis of DPT and pSS disease activity scores found that DPT frequency had a negative correlation with ESSDAI and SSDAI. This study suggests that peripheral DPT may play a protective role in pSS. The frequency of peripheral DPT cells can be used as an indicator for disease activity. Regulating the expression of peripheral DPT cells is expected to become a new strategy for treatment of pSS.
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Goulabchand, Radjiv, Camille Roubille, David Montani, Pierre Fesler, Arnaud Bourdin, Nicolas Malafaye, Jacques Morel, et al. "Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren’s Syndrome: Data from the French Health Insurance Database." Journal of Clinical Medicine 10, no. 21 (October 30, 2021): 5115. http://dx.doi.org/10.3390/jcm10215115.
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Primary Sjögren’s syndrome (pSS) is an autoimmune disease, associated with a high risk of lymphoma. Mounting evidence suggests that cardiovascular morbidity and mortality are higher in patients with pSS, although data are heterogeneous. The aim of this study was to assess whether pSS patients are at higher risk of hospitalisation for cardiovascular events (CVEs), venous thromboembolic events (VTEs), pulmonary hypertension (PH), and sleep apnoea syndrome (SAS). Through a nationwide population-based retrospective study using the French health insurance database, we selected new-onset pSS in-patients hospitalised between 2011 and 2018. We compared the incidence of CVEs (ischemic heart diseases (IHDs), strokes, and heart failure), SAS, VTEs, and PH with an age- and sex-matched (1:10) hospitalised control group. The calculations of adjusted hazard ratios (aHR) included available confounding factors. We studied 25,661 patients hospitalised for pSS compared with 252,543 matched patients. The incidence of hospitalisation for IHD, SAS, and PH was significantly higher in pSS patients (aHR: 1.20 (1.06–1.34); p = 0.003, aHR: 1.97 (1.70–2.28); p < 0.001, and aHR: 3.32 (2.10–5.25); p < 0.001, respectively), whereas the incidence of stroke, heart failure, and VTE was the same between groups. Further prospective studies are needed to confirm these results and to explore the pathophysiological mechanisms involved.
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Andrés-Rodríguez, Laura, Xavier Borràs, Albert Feliu-Soler, Adrián Pérez-Aranda, Antoni Rozadilla-Sacanell, Belén Arranz, Jesús Montero-Marin, et al. "Machine Learning to Understand the Immune-Inflammatory Pathways in Fibromyalgia." International Journal of Molecular Sciences 20, no. 17 (August 29, 2019): 4231. http://dx.doi.org/10.3390/ijms20174231.
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Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, and physical and emotional symptoms. Although its pathophysiology is largely unknown, immune-inflammatory pathways may be involved. We examined serum interleukin (IL)-6, high sensitivity C-reactive protein (hs-CRP), CXCL-8, and IL-10 in 67 female FM patients and 35 healthy women while adjusting for age, body mass index (BMI), and comorbid disorders. We scored the Fibromyalgia Severity Score, Widespread Pain Index (WPI), Symptom Severity Scale (SSS), Hospital Anxiety (HADS-A), and Depression Scale and the Perceived Stress Scale (PSS-10). Clinical rating scales were significantly higher in FM patients than in controls. After adjusting for covariates, IL-6, IL-10, and CXCL-8 were lower in FM than in HC, whereas hs-CRP did not show any difference. Binary regression analyses showed that the diagnosis FM was associated with lowered IL-10, quality of sleep, aerobic activities, and increased HADS-A and comorbidities. Neural networks showed that WPI was best predicted by quality of sleep, PSS-10, HADS-A, and the cytokines, while SSS was best predicted by PSS-10, HADS-A, and IL-10. Lowered levels of cytokines are associated with FM independently from confounders. Lowered IL-6 and IL-10 signaling may play a role in the pathophysiology of FM.