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Journal articles on the topic 'Psychiatric adverse effect'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Joo, Sung Woo, Young-Gi Min, Sang-Cheon Choi, and Eun Jung Park. "The Intoxication of Beta Blocker with Psychiatric Drugs Focused on the Cardiovascular Adverse Effects." Journal of The Korean Society of Clinical Toxicology 14, no. 2 (2016): 100–106. http://dx.doi.org/10.22537/jksct.14.2.100.

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Purpose: Beta blocker (BB) has been prescribed for anxiety and panic disorder. Patients intoxicated by psychiatric drugs have often been exposed to BB. Moreover, BB overdose has adverse effects including cardiovascular effects, which can be life-threatening. This study was conducted to identify the characteristics of BB intoxication with psychiatric drugs and the adverse effects on the cardiovascular system. Methods: A single center, retrospective study was performed from January 2010 to December 2015. A total of 4,192 patients visited the emergency department (ED) with intoxication, and 69 wi

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Bramness, J. G. "Cannabis and cannabinoids for mental health indications: evidence of effect and adverse events." European Psychiatry 66, S1 (2023): S26. http://dx.doi.org/10.1192/j.eurpsy.2023.101.

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AbstractCannabis and cannabinoids have been marketed and sold for a variety of different psychiatric conditions like e.g., anxiety, sleep problems, ADHD, PTSD, and even psychosis. Some of these indications may be reasonable, but for some a more conservative approach should be upheld. There are quite a few open studies and case reports on effects, while larger blinded RCTs either fail to find these effects or are lacking. The lecture aims at presenting the most recent evidence for the use of cannabis and cannabinoids for psychiatric indications, alongside a presentation of adverse effects.Discl

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Mosin Kadr, Jyoti Perke. "Effect of Self-instructional Module on Knowledge Regarding Lithium Carbonate Therapy among the Staff Nurses in Selected Psychiatric Institutions of Mumbai City." Innovational Journal of Nursing and Healthcare 09, no. 04 (2023): 68–72. http://dx.doi.org/10.31690/ijnh.2023.v09i04.015.

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Introduction: Mental illness affects one in every eleven individuals in India, or approximately 50 million Indians are afflicted with psychiatric disorders. Approximately one in ten thousand individuals with psychiatric disorders will experience mood disorders at some point in their lives. Arecent NICE guideline from 2014 designates lithium as the initial maintenance treatment for bipolar affective disorder. Materials and Methods: A quasi-experimental, one group pre-test, post-test design has been adopted to assess the effectiveness of selfinstructional module (SIM) on knowledge, among the sta

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Kumamoto, Asaki, Yuhei Chiba, Akira Suda, Akitoyo Hishimoto, and Akihiko Kase. "A Severe Dementia Case in End of Life Care with Psychiatric Symptoms Treated by Perampanel." Journal of Epilepsy Research 11, no. 1 (2021): 93–95. http://dx.doi.org/10.14581/jer.21012.

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Epilepsy is known to comorbid with Alzheimer's disease. It can promote cognitive decline, and eventually worsen their prognosis and mortality. It is sometimes difficult to find a suitable drug because of the adverse effects. Perampanel has a unique mechanism of action that antagonizes α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid type glutamate receptor. Here, we report a case of severe dementia due to Alzheimer's disease with intractable epilepsy, which perampanel effected for controlling seizures with less adverse effects. The subject is an 89-year-old Japanese woman with severe demen

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Nesic, Zorica, Dragan Delic, Milica Prostran, Radan Stojanovic, Sonja Vuckovic, and Zoran Todorovic. "Psychiatric adverse effects induced by recombinant interferon alfa in patients with chronic hepatitis C." Medical review 57, no. 5-6 (2004): 219–26. http://dx.doi.org/10.2298/mpns0406219n.

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Introduction Hepatitis C virus infection is a slowly progressive chronic disease and the most common cause of chronic liver disease. Presently, interferon alfa based therapies, with or without ribavirin, are standard treatment for chronic hepatitis C virus infection. The most troublesome psychiatric side effects of interferon therapy in our patients are: insomnia, irritability, anxiety, mood changes, short temper, emotional and affective lability, impaired cognitive function, apathy, loss of motivation and the most serious depression with or without suicidal ideas. Material and methods In our

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Krull, Florian, Ibrahim Akkouh, Timothy Hughes, et al. "Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort." Progress in Neuro-Psychopharmacology and Biological Psychiatry 112 (January 2022): 110408. http://dx.doi.org/10.1016/j.pnpbp.2021.110408.

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Breggin, Peter R. "Intoxication Anosognosia: The Spellbinding Effect of Psychiatric Drugs." Ethical Human Psychology and Psychiatry 8, no. 3 (2006): 201–16. http://dx.doi.org/10.1891/ehppij-v8i3a003.

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Why do so many individuals persist in taking psychoactive substances, including psychiatric drugs, after adverse mental and behavioral effects have become severe and even disabling? The author has previously proposed the brain-disabling principle of psychiatric treatment that all somatic psychiatric treatments impair the function of the brain and mind. Intoxication anosognosia (medication spellbinding) is an expression of this drug-induced mental disability. Intoxication anosognosia causes the victim to underestimate the degree of drug-induced mental impairment, to deny the harmful role that t

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Burgess, C., A. O’Donohoe, and M. Gill. "Agony and ecstasy: a review of MDMA effects and toxicity." European Psychiatry 15, no. 5 (2000): 287–94. http://dx.doi.org/10.1016/s0924-9338(00)00396-5.

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SummaryBackgroundBackground – Ecstasy is a recreational drug with an anecdotal reputation for safety. However, reports of adverse effects and fatalities have increased in the medical and popular press.MethodsMethod – Literature search and review.ResultsResults – Acute Ecstasy toxicity does not appear to be due to overdose and cannot be solely attributed to the nature of the usual ambient environment. Adverse effects include hyperthermia, seizures, cardiac arrhythmias, hepatotoxicity, hyponatraemia and many psychiatric disorders. Ecstasy causes serotonergic neurotoxicity in the brains of animal

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Jermain, Donna M., and M. Lynn Crismon. "Psychotropic Drug-Related Rhabdomyolysis." Annals of Pharmacotherapy 26, no. 7-8 (1992): 948–54. http://dx.doi.org/10.1177/106002809202600719.

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OBJECTIVE: The objective of this review is to discuss the pathophysiology and potential etiologies of rhabdomyolysis in psychiatric patients, with an emphasis on psychotropic drug-induced rhabdomyolysis. DATA SOURCES: References were obtained through an on-line search of MEDLINE, using English-language and human literature only. STUDY SELECTION: Because the topic is a potential drug-induced adverse effect, no controlled studies are available. Most of the literature are case reports and series of case reports. DATA EXTRACTION: The quality of case reports was assessed using the Food and Drug Adm

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K Bajwa, Waheed, Smrithi Divakaran, and Jessica Demotts. "Dose Related Psychiatric Adverse Effect of Lamotrigine in Management of Bipolar Disorder." Journal of Psychiatry and Psychiatric Disorders 01, no. 04 (2017): 208–14. http://dx.doi.org/10.26502/jppd.2572-519x0021.

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Shaima, Almufarej, Alogailan Basmah, Elnasih Abdulrahman, Almotairi Maha, and Baabdullah Shahad. "Antipsychotic Medication Adverse Effect on Autistic Patients among Saudi Papulation." International Journal of Current Science Research and Review 06, no. 06 (2023): 3678–87. https://doi.org/10.5281/zenodo.8084828.

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<strong>ABSTRACT:</strong> <strong>Background</strong>: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by persistent impairments in social communication and restricted, repetitive patterns of behavior. Pharmacological treatments for the core symptoms of ASD are currently lacking, with existing medications primarily targeting associated symptoms and comorbidities such as irritability and psychiatric conditions. Early implementation of behavioral therapies has shown promise in alleviating core ASD symptoms and improving functional outcomes. Combining behav

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Knopf, Alison. "Keep your eye on…" Brown University Child and Adolescent Behavior Letter 41, no. 7 (2025): 2. https://doi.org/10.1002/cbl.30879.

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Kurczych, Katarzyna, Agnieszka Makulska, and Iwona Kurkowska-Jastrzębska. "Psychotic disorders as an adverse effect of levetiracetam or discontinuation of mood stabilising drugs." Pharmacotherapy in Psychiatry and Neurology 36, no. 2 (2020): 155–63. http://dx.doi.org/10.33450/fpn.2020.06.003.

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Patients using antiepileptic drugs (AEDs) suffer from relatively common adverse effects manifested by psychotic and behavioural disorders. This is particularly true in patients with a history of psychiatric disorders and using levetiracetam. This has important therapeutic implications because very often discontinuation of AED is the only available option. Simultaneous use of mood-stabilising AEDs reduces this risk; however, too rapid withdrawal of such AEDs can also induce psychotic symptoms. We present four cases of epilepsy patients who experienced psychiatric disorders induced by LEV. In on

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Correll, Christoph U. "Balancing Efficacy and Safety in Treatment with Antipsychotics." CNS Spectrums 12, S17 (2007): 12–20. http://dx.doi.org/10.1017/s1092852900026298.

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AbstractBalancing efficacy with tolerability and safety of prescribed treatments is critical to optimizing antipsychotic treatment outcomes in the mentally ill. Symptom control, symptom remission, and functional recovery are only realistic goals when treatments are both effective and well tolerated. The consideration of predictable differences in antipsychotic adverse-effect profiles is central to successful illness management. Minimizing adverse effects on alertness, motivation, cognition, sexual/reproductive functioning, and physical health enhancesmental health outcomes, partly through impr

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Westergren, Tone, Sigrid Narum, and Marianne Klemp. "Critical appraisal of adverse effects reporting in the ‘Treatment for Adolescents With Depression Study (TADS)’." BMJ Open 9, no. 3 (2019): e026089. http://dx.doi.org/10.1136/bmjopen-2018-026089.

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ObjectiveTo identify all publications from the ‘Treatment for Adolescents With Depression Study (TADS)’ and assess the findings regarding occurrence of any adverse effects in the treatment groups both for the short-term and long-term study stages.DesignDescriptive analysis of TADS publications with any information on adverse effects.ResultsWe identified 48 publications describing various aspects of the TADS, in which 439 adolescent patients received treatment with fluoxetine, cognitive–behavioural therapy, cognitive–behavioural therapy plus fluoxetine or placebo. Eight publications were assess

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Edinoff, Amber N., Haseeb A. Akuly, Tony A. Hanna, et al. "Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review." Neurology International 13, no. 3 (2021): 387–401. http://dx.doi.org/10.3390/neurolint13030038.

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Depression is the most prevalent psychiatric disorder in the world, affecting 4.4% of the global population. Despite an array of treatment modalities, depressive disorders remain difficult to manage due to many factors. Beginning with the introduction of fluoxetine to the United States in 1988, selective serotonin reuptake inhibitors (SSRIs) quickly became a mainstay of treatment for a variety of psychiatric disorders. The primary mechanism of action of SSRIs is to inhibit presynaptic reuptake of serotonin at the serotonin transporter, subsequently increasing serotonin at the postsynaptic memb

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Alchakee, Aminah, Munazza Ahmed, Leen Eldohaji, Hamid Alhaj, and Maha Saber-Ayad. "Pharmacogenomics in Psychiatry Practice: The Value and the Challenges." International Journal of Molecular Sciences 23, no. 21 (2022): 13485. http://dx.doi.org/10.3390/ijms232113485.

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The activity of cytochrome P450 enzymes is influenced by genetic and nongenetic factors; hence, the metabolism of exogenous psychotropic medications and potentially some endogenous neuropeptides is variably affected among different ethnic groups of psychiatric patients. The aim of this review is to highlight the most common cytochrome P450 isoenzymes associated with the metabolism of psychotropic medications (antidepressants, antipsychotics, and mood stabilizers), their variations among different populations, their impact on endogenous neurotransmitters (dopamine and serotonin), and the effect

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Beatson, Josephine, and Suzanna Taryan. "Predisposition to Depression: The Role of Attachment." Australian & New Zealand Journal of Psychiatry 37, no. 2 (2003): 219–25. http://dx.doi.org/10.1046/j.1440-1614.2003.01126.x.

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Objective: To examine the hypothesis that adverse early relational experiences causing activation of the hypophysial-pituitary-adrenal (HPA) axis during critical early stages of development can predispose to depression. Patients thus affected are likely to manifest insecure patterns of attachment in close relationships and are vulnerable to depression after adverse life events. Method: The literature pertaining to sensitization of the HPA axis in early life and the neurobiology of attachment is examined. Results: Adverse early relational experiences can result in activation of the HPA axis, ca

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Gómez Sánchez-Lafuente, C., R. Reina Gonzalez, F. Moreno De Lara, A. De Severac Cano, E. Mateos Carrasco, and A. González Moreno. "Twenty-four months experience of paliperidone long-acting injection in a Spanish psychiatric service: A mirror image analysis." European Psychiatry 33, S1 (2016): S541. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1999.

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IntroductionLack of adherence is a common cause of relapse in schizophrenia. Long-acting antipsychotics have shown in recent studies that they improve compliance. However, some randomised controlled trials showed no difference in relapse rates between oral medication and long-acting injections.ObjectiveTo report the use of paliperidone palmitate in an Acute Psychiatrist Unit in Spain.MethodRetrospective observational study of 42 patients prescribed paliperidone palmitate (PLAI) during an admission at Acute Psychiatric unit in Málaga. In the mirror image analysis, the main outcome measure was t

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Leucht, Stefan, Sandra Hierl, Werner Kissling, Markus Dold, and John M. Davis. "Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses." British Journal of Psychiatry 200, no. 2 (2012): 97–106. http://dx.doi.org/10.1192/bjp.bp.111.096594.

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BackgroundThe efficacy of psychopharmacological treatments has been called into question. Psychiatrists are unfamiliar with the effectiveness of common medical drugs.AimsTo put the efficacy of psychiatric drugs into the perspective of that of major medical drugs.MethodWe searched Medline and the Cochrane Library for systematic reviews on the efficacy of drugs compared with placebo for common medical and psychiatric disorders, and systematically presented the effect sizes for primary efficacy outcomes.ResultsWe included 94 meta-analyses (48 drugs in 20 medical diseases, 16 drugs in 8 psychiatri

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Wierzbiński, Piotr, Joanna Hubska, Michał Henzler, Bartłomiej Kucharski, Rafał Bieś, and Marek Krzystanek. "Depressive and Other Adverse CNS Effects of Fluoroquinolones." Pharmaceuticals 16, no. 8 (2023): 1105. http://dx.doi.org/10.3390/ph16081105.

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Fluoroquinolones (FQs) are widely used drugs around the world. This is a result of their broad spectrum of antibacterial activity, high bioavailability, and known efficacy. Since they appeared on the market, their prescribing frequency has gradually increased. In 2011, FQs became the third most prescribed class of antibiotics in the US. Widespread use of these drugs resulted in an increasing number of reported side effects. In 2016, the FDA warned about significant side effects, including mental disorders in the form of anxiety, psychotic symptoms, insomnia, and depression. Psychiatric adverse

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Sharma, Charu, Bassem Sadek, Sameer N. Goyal, Satyesh Sinha, Mohammad Amjad Kamal, and Shreesh Ojha. "Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–26. http://dx.doi.org/10.1155/2015/238482.

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The cannabinoid molecules are derived fromCannabis sativaplant which acts on the cannabinoid receptors types 1 and 2 (CB1and CB2) which have been explored as potential therapeutic targets for drug discovery and development. Currently, there are numerous cannabinoid based synthetic drugs used in clinical practice like the popular ones such as nabilone, dronabinol, and Δ9-tetrahydrocannabinol mediates its action through CB1/CB2receptors. However, these synthetic basedCannabisderived compounds are known to exert adverse psychiatric effect and have also been exploited for drug abuse. This encourag

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Melo, Ana Paula Souto, Eduardo de Paula Lima, Fabiana Cristina Ribeiro de Barros, Lidyane do Valle Camelo, and Mark Drew Crosland Guimarães. "Homelessness and incarceration among psychiatric patients in Brazil." Ciência & Saúde Coletiva 23, no. 11 (2018): 3719–33. http://dx.doi.org/10.1590/1413-812320182311.12522016.

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Abstract Psychiatric patients are at increased risk of adverse life events, such as being incarcerated and homelessness in their life course. Using data from a cross-sectional multicenter study of 2,475 patients selected from 26 mental health services in Brazil, we examined the association of sociodemographic, clinical, behavioral, and adverse life characteristics with history of homelessness, incarceration or their co-occurrence during lifetime. Odds ratios were obtained by multinomial logistic regression models. The prevalence of homelessness, incarceration and co-occurrence of these two con

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Osman, M., and M. D. McCauley. "Psychiatric shades of grey: mirtazapine-induced hair discoloration and hair loss." Irish Journal of Psychological Medicine 33, no. 3 (2016): 175–78. http://dx.doi.org/10.1017/ipm.2015.71.

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IntroductionMirtazapine is indicated in the treatment of major depressive disorder particularly in selective serotonin re-uptake inhibitors resistance. Its effect on hair loss is rare with no previous documented effect on hair colour.MethodReview of relevant literature and description of a case report of a 54-year-old male patient who developed alopecia and hair discoloration after initiation of mirtazapine treatment.ResultsUpon cessation of mirtazapine treatment full restoration of hair colour and regrowth of hair was attained within 10 weeks.DiscussionThere was clear temporal relationship be

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Anari, A. Mehdizadeh Zare, and A. Ghaffarinejad. "Seborrheic dermatitis: Could be a rare side effect of nortriptyline?" European Psychiatry 26, S2 (2011): 1050. http://dx.doi.org/10.1016/s0924-9338(11)72755-9.

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In Iran, although new antidepressants are available, nortriptyline is widely used because of being economical and accessible.Physicians prescribe it for psychiatric disorders, especially in hospitalized or outpatients with depression.Clinicians know its common side effects, for example anticholinergic effects, but such as other drugs it has rare adverse effects.Here, we present a 27 years old woman with major depression disorder who has been treated with nortriptyline/75 mg/day. After a week she came back with seborrheic dermatitis, the diagnosis was confirmed by a dermatologist. Lesions disap

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Dell’Osso, Liliana, Chiara Bonelli, Benedetta Nardi, et al. "Rethinking Clozapine: Lights and Shadows of a Revolutionary Drug." Brain Sciences 14, no. 1 (2024): 103. http://dx.doi.org/10.3390/brainsci14010103.

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The current literature globally highlights the efficacy of Clozapine in several psychiatric disorders all over the world, with an FDA indication for reducing the risk of repeated suicidal behavior in patients with schizophrenia or schizoaffective disorder. A growing field of research is also stressing a possible broader beneficial effect of Clozapine in promoting neuroprotection and neurotrophism. However, this drug is linked to several life-threatening side effects, such as agranulocytosis, myocarditis and seizures, that limit its use in daily clinical practice. For this work, a search was pe

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Mintz, David. "Recovery from Childhood Psychiatric Treatment: Addressing the Meaning of Medications." Psychodynamic Psychiatry 50, no. 1 (2022): 131–48. http://dx.doi.org/10.1521/pdps.2022.50.1.131.

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Medications exert effects not only through biological mechanisms but also through the meanings that they carry. While positive effects (e.g., the placebo effect) are broadly recognized, psychiatry is often less attuned to the negative effects that are mediated through the meaning of medications. These negative effects may be especially pronounced when noxious meanings and countertherapeutic aspects of medications are incorporated into the unfolding development of a child and not countered by psychotherapeutic experiences that allow iatrogenic meanings to be placed in context. In this paper, ps

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Phan, Tuan Anh, and Rob Kok. "The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients." Geriatrics 10, no. 2 (2025): 57. https://doi.org/10.3390/geriatrics10020057.

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Aim/Objectives: To investigate whether frailty predicts adherence to psychotropic drug treatment or adverse drug reactions, within 6 months after treatment initiation. Methods: A prospective cohort study including 77 patients over the age of 65, treated in one large psychiatric institute in the Netherlands. Patients were assessed at baseline for their frailty status, using different operationalizations of the Fried frailty criteria. Data on duration of psychotropic drug treatment and number of reported adverse drug reactions were retrieved from electronic patient files. Regression analyses wer

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Alm, Susanne, Sara Brolin Låftman, Fredrik Sivertsson, and Hannes Bohman. "Poor family relationships in adolescence as a risk factor of in-patient psychiatric care across the life course: A prospective cohort study." Scandinavian Journal of Public Health 48, no. 7 (2020): 726–32. http://dx.doi.org/10.1177/1403494820902914.

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Background: Previous research has shown that poor family relations in childhood are associated with adverse mental health in adulthood. Yet, few studies have followed the offspring until late adulthood, and very few have had access to register-based data on hospitalisation due to psychiatric illness. The aim of this study was to examine the association between poor family relations in adolescence and the likelihood of in-patient psychiatric care across the life course up until age 55. Methods: Data were derived from the Stockholm Birth Cohort study, with information on 2638 individuals born in

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Oshri, Assaf, Joshua C. Gray, Max M. Owens, et al. "Adverse Childhood Experiences and Amygdalar Reduction: High-Resolution Segmentation Reveals Associations With Subnuclei and Psychiatric Outcomes." Child Maltreatment 24, no. 4 (2019): 400–410. http://dx.doi.org/10.1177/1077559519839491.

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The aim of the present study was 2-fold: (1) to utilize improved amygdala segmentation and exploratory factor analysis to characterize the latent volumetric structure among amygdala nuclei and (2) to assess the effect of adverse childhood experiences (ACEs) on amygdalar morphometry and current psychiatric symptoms. To investigate these aims, structural (T1) MRI and self-report data were obtained from 119 emerging adults. Regression analysis showed that higher ACE scores were related to reduced volume of the right, but not the left, amygdalar segments. Further, exploratory factor analysis yield

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Manolis, Theodora A., Antonis A. Manolis, and Antonis S. Manolis. "Cardiovascular Safety of Psychiatric Agents: A Cautionary Tale." Angiology 70, no. 2 (2018): 103–29. http://dx.doi.org/10.1177/0003319718780145.

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Psychiatric agents are among the most commonly prescribed medications. Despite the advent of newer generation agents, patients receiving them still experience cardiovascular (CV) side effects. However, these agents may have heterogeneous properties, calling for an individualized approach based on efficacy and also on the particular side effect profile of each specific agent. Proarrhythmic effects arising from drug-induced long-QT syndrome and consequent potentially life-threatening polymorphic ventricular arrhythmias in the form of torsade de pointes, the metabolic syndrome contributing to ath

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Demler, Tammie Lee, Samantha Morales, Geoffrey Brown, Andrea Derosas, and Claudia Lee. "Olanzapine-Induced Hypothermia: A Case Report in an Elderly Black Male Patient Diagnosed with Bipolar 1 Type Disorder." OBM Geriatrics 08, no. 03 (2024): 1–8. http://dx.doi.org/10.21926/obm.geriatr.2403288.

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There are few reports that describe incidence of hypothermia in patients treated with olanzapine. We report a case of an elderly 83-year-old black male, readmitted to the state psychiatric hospital December 2023 due to psychiatric exacerbation after 6 months of successful discharge to community, who experienced a fall and profound hypothermia with bradycardia that resulted in a 10-day acute hospitalization in January 2024. Medical workup was unrevealing except for multivessel disease found on CT stroke study of the brain. When patient returned to inpatient psychiatric hospital, his psychiatric

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Azraai, Meor, Jeanette H. Pham, Wenye F. Looi, et al. "Observational cohort study of the triggers, diagnoses and outcomes of the medical emergency team (MET) response in adult psychiatry inpatients colocated with acute medical services in Australia." BMJ Open 11, no. 10 (2021): e046110. http://dx.doi.org/10.1136/bmjopen-2020-046110.

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ObjectivesMedical emergencies in psychiatric inpatients are challenging due to the model of care and limited medical resources. The study aims were to determine the triggers and outcomes of a medical emergency team (MET) call in psychiatric wards, and the risk factors for MET activation and mortality.DesignRetrospective multisite cohort study.SettingPsychiatry units colocated with acute medical services at three major metropolitan hospitals in Melbourne, Australia.ParticipantsWe studied 487 adult inpatients who experienced a total of 721 MET calls between January 2015 and January 2020. Patient

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Sharma, Nishant, Sangeeta Bhat, Divya Ravi, and Pius Ochieng. "Severe hypothermia, bradycardia and cardiac arrest in association with risperidone." BMJ Case Reports 13, no. 5 (2020): e234999. http://dx.doi.org/10.1136/bcr-2020-234999.

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Antipsychotic medications, including risperidone, are widely used in the treatment of psychiatric disorders, including schizophrenia. While hyperthermia is an establish adverse effect of these medications, less is known about the rare occurrence of hypothermia. We present two patients who developed hypothermia, bradycardia and cardiac arrest in association with risperidone. We briefly review previously similarly reported cases.

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Moreira, C. A., A. R. Soares, and G. Maia. "Psychiatric antiepileptics side effects: A case report." European Psychiatry 33, S1 (2016): S348. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1230.

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IntroductionPsychiatric disorders in epilepsy have a multifactorial etiology, being pharmacotherapy only one of many risk factors, which can be both biological and psychosocial. The adverse effects of antiepileptics (AEDs) embrace all categories of psychiatric symptomatology, including disturbances of consciousness, psychotic state, neurotic state, behaviour and character disorder. In fact, Psychotropic effects of AEDs require further research because many relevant parameters related to pathological mechanisms, frequency, psychopathology, and prognosis are not well understood.ObjectivesThe aut

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Glushkova, A. V., and N. V. Semenova. "Working conditions and their effect on the health level of psychiatric staff (literature review)." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 1 (April 2, 2020): 3–7. http://dx.doi.org/10.31363/2313-7053-2020-1-3-7.

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The range of adverse environmental factors affecting the health of psychiatrists is quite wide. It includes biological and chemical substances, emotional exhaustion and professional burnout, permanent exposure to stress factors of an aggressive environment, forced working posture, tension of analyzer systems and many others. In addition, psychiatrists work under conditions of high emotional stress, which leads to rapid depletion of the nervous system, the development of a syndrome of professional burnout.

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Kamath, Ashwin, and Zahoor Ahmad Rather. "Melatonin for Atypical Antipsychotic-Induced Metabolic Adverse Effects: A Meta-Analysis of Randomized Controlled Trials." BioMed Research International 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/4907264.

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The objective of our study was to determine the effect of melatonin administration on atypical antipsychotic-induced metabolic adverse effects in patients with psychiatric disorders. A systematic search was performed in PUBMED, Cochrane Library, Scopus, Web of Science, and EBSCOhost electronic databases. Randomized controlled trials studying the effect of melatonin on antipsychotic-induced metabolic adverse effects were identified and subjected to meta-analysis. Four studies were included in the meta-analysis, including 57 patients on melatonin and 61 patients on placebo. Melatonin produced a

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Tamam, Lut, Deniz Yerdelen, and Nurgul Ozpoyraz. "Psychosis Associated with Interferon Alfa Therapy for Chronic Hepatitis B." Annals of Pharmacotherapy 37, no. 3 (2003): 384–87. http://dx.doi.org/10.1345/aph.1c266.

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OBJECTIVE: To report a case of persistent psychosis that developed during interferon alfa (IFN-α) therapy for chronic hepatitis B. CASE SUMMARY: A 26-year-old man who was diagnosed with active chronic hepatitis B began treatment with IFN-α. Five months after initiation of therapy, he developed acute psychosis with prominent persecutory delusions and auditory hallucinations. Despite discontinuation of IFN-α therapy and addition of antipsychotic drug treatment, only partial recovery from psychosis was observed after 4 months of hospitalization. DISCUSSION: Unlike many previously reported cases,

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Gomes, Joana, Diana Durães, André Sousa, and Hugo Afonso. "Isoniazid-Induced Acute Psychosis in a Patient with Pleural Tuberculosis." Case Reports in Psychiatry 2019 (February 13, 2019): 1–3. http://dx.doi.org/10.1155/2019/4272941.

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Tuberculosis is one of the top 10 causes of death and the leading cause from a single infectious agent (above HIV/AIDS). Isoniazid is highly bactericidal against replicating tubercle bacilli and is a component of all antituberculous chemotherapeutic regimens currently recommended by the World Health Organization (WHO). Several neuropsychiatric adverse effects, following both therapeutic and overdose use of isoniazid, have been described and isoniazid-induced psychosis, although uncommon, has been reported in the literature. We describe the case of a 21-year-old black woman, with no prior psych

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Allen, Nicholas D., Jonathan G. Leung, and Brian A. Palmer. "Mirtazapine's effect on the QT interval in medically hospitalized patients." Mental Health Clinician 10, no. 1 (2020): 30–33. http://dx.doi.org/10.9740/mhc.2020.01.030.

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Abstract Introduction Mirtazapine is generally well tolerated in medically ill patients with and without formal psychiatric comorbidity to target sleep, appetite, nausea, and pain. However, there is little data regarding mirtazapine's potential to prolong the corrected QT interval (QTc) in this population. Methods From a retrospective cohort of patients hospitalized on a variety of medical units for whom a psychiatric consult recommended mirtazapine, electrocardiogram (ECG) data were extracted for ECGs obtained up to 3 days before and 6 days after the initial consult. Descriptive statistics we

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Goodlet, Kellie J., Monika T. Zmarlicka, and Alyssa M. Peckham. "Drug–drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs." CNS Spectrums 24, no. 03 (2018): 287–312. http://dx.doi.org/10.1017/s109285291800113x.

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Psychotropic medications are frequently co-prescribed with antiretroviral therapy (ART), owing to a high prevalence of psychiatric illness within the population living with HIV, as well as a 7-fold increased risk of HIV infection among patients with psychiatric illness. While ART has been notoriously associated with a multitude of pharmacokinetic drug interactions involving the cytochrome P450 enzyme system, the magnitude and clinical impact of these interactions with psychotropics may range from negligible effects on plasma concentrations to life-threatening torsades de pointes or respiratory

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Pessoa, R. M. P., R. K. V. Martins Filho, G. R. Rodrigues, et al. "P25: Effects of cannabidiol on behavioral and psychological symptoms of vascular dementia: a randomized, double-blind, placebo-controlled trial." International Psychogeriatrics 36, S1 (2024): 132–33. http://dx.doi.org/10.1017/s1041610224002588.

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Objectives: To evaluate the effect and safety of Cannabidiol (CBD) on behavioral and psychological symptoms in elderly with Vascular dementia (VD).Methods: Double- blind, randomized, placebo-controlled clinical trial involving elderly patients with VD at the psychogeriatrics and vascular dementia outpatient clinic at Hospital das Clínicas de Ribeirão Preto. The intervention evaluated was the use of CBD 300mg/day compared to placebo. The instruments used are: Neuropsychiatric Inventory, Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression Scale, Side Effects Scale, Mini- Mental Sta

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Barbosa, Renata S. D., and Maria A. Vieira-Coelho. "Probiotics and prebiotics: focus on psychiatric disorders – a systematic review." Nutrition Reviews 78, no. 6 (2019): 437–50. http://dx.doi.org/10.1093/nutrit/nuz080.

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Abstract Context The gut-brain axis and microbial dysbiosis may play a role in psychiatric diseases. In this view, the gut microbiota has been considered a potential therapeutic target using probiotics and prebiotics. Objective This systematic review aims to find the existing clinical evidence that may justify the use of probiotics or prebiotics in psychiatric patients. Data sources PRISMA guidelines were followed for a systematic literature review of randomized controlled trials that assessed the effect of prebiotics or probiotics in patients diagnosed with a classified psychiatric disorder.

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Joshi, Harsh M., Sapna Gupta, Supriya Malhotra, and Pankaj Patel. "A case series on drug induced hyponatremia: uncommon adverse effect of commonly used drugs." International Journal of Basic & Clinical Pharmacology 7, no. 6 (2018): 1200. http://dx.doi.org/10.18203/2319-2003.ijbcp20182106.

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Older patients suffering from depression and psychosis have markedly increased since last decade. So, has the use of antidepressants and antipsychotics. The prevalence of hyponatremia due to these drugs is common in general as well as psychiatric practice. It may also lead to life threatening morbidity and mortality. Loss of renal function, polypharmacy, dementia and other conditions of advanced age can either exacerbate the severity of hyponatremia or mask its onset. In this case series, total four cases were reported of hyponatremia and drugs causing it were escitalopram, quetiapine, tianept

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Jha, Amit. "A naturalistic study on side effects of selective serotonin reuptake inhibitors in psychiatric out-patient department." Journal of Psychiatrists' Association of Nepal 11, no. 2 (2022): 22–28. http://dx.doi.org/10.3126/jpan.v11i2.57634.

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Introduction: >Antidepressants are one of the most commonly prescribed psychotropic drugs. Six SSRIs are approved for various disorders. SSRIs have fewer side effects owing to its selective blocking the serotonin transporter. Nonetheless SSRI has several troublesome side effects, including nausea, diarrhoea, headache, dizziness, sexual side effects, tachycardia, or weight gain. Methodology: This cross-sectional comprised of 200 patients who were divided into two groups. Group 1 had participants who had received SSRI for less than 6 weeks duration and group 2 had patients who had taken SSRI

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França Drissen, Viviani, and Analia Claudia Sabattini. "Nocebo effect as the opposite of the placebo effect: Systematic review." Seminars in Medical Writing and Education 2 (December 31, 2023): 23. http://dx.doi.org/10.56294/mw202323.

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Background: The placebo effect refers to a clinical improvement in a patient as a result of interactions with the treating physician, information received about the treatment, and the defined therapy. The placebo effect is a broad field involving complex neurobiological and neurotransmitter mechanisms, and recent studies have provided evidence that these effects are genuine biopsychosocial phenomena. Although placebos cannot cure a disease, they can provide relief to the patient and improve the effectiveness of pharmaceuticals. The effectiveness of placebos depends on several factors, includin

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Costa, M. L., and A. Cerame. "Dopamine dysregulation syndrome after prescription of dopamine agonists: a case report." European Psychiatry 65, S1 (2022): S720. http://dx.doi.org/10.1192/j.eurpsy.2022.1857.

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Introduction We present the case of a 65-year-old woman with multiple and chronic psychosomatic symptoms. Due to motor impairments she was diagnosed in 2009 with Parkinson’s Disease (PD) by the neurology department and empirical treatment with levodopa was prescribed. However, the patient increased her levodopa intake by three times the recommended dose. The patient presented many adverse effects, including psychotic symptoms, that were interrupted after the levodopa intake was ended during a two month internament in a psychiatric unit. Dopamine dysregulation syndrome (DDS) is a condition in w

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Balashova, A. V., D. V. Mamleeva, L. V. Machekhina, and E. N. Dudinskaya. "Metabolic adverse effects of antipsychotics: the state of the problem and management options." Obesity and metabolism 19, no. 4 (2023): 431–41. http://dx.doi.org/10.14341/omet12935.

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Antipsychotic drugs are widely used for many psychiatric disorders, such as schizophrenia, bipolar affective disorder, delusions and hallucinations due to neurological disorders, depression with severe psychotic symptoms. Metabolic disorders including weight gain, dyslipidemia and hyperglycemia are one of the most common side effects of antipsychotic therapy. Psychiatric patients have higher risk of cardiovascular disease, so that the development of metabolic side effects is an important clinical problem that should be solved. Antipsychotic-induced weight gain may cause distress that leads to

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C Genovese, Ann, and Simon Longhi. "Corneal edema from amantadine toxicity in child with fetal alcohol syndrome." International Journal of Case Reports and Images 16, no. 2 (2025): 1–6. https://doi.org/10.5348/101512z01ag2025cr.

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Amantadine has been used in both neurology and psychiatry for an increasingly wide array of clinical indications, often with significant success in managing difficult-to-treat neurological, developmental, and psychiatric disorders with ongoing research into its potential benefit for many more, often entirely unrelated health conditions. The authors summarize the literature to date which describes corneal edema as a less well-known potential adverse effect of this medication, particularly in children and adolescents. We present a case in which the timely identification of bilateral corneal edem

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Davey, Anuradha, Parul Sharma, Sanjeev Davey, Arvind Shukla, Kajal Srivastava, and Shaili Vyas. "Are the adverse psychiatric outcomes reflection of occupational stress among nurses: An exploratory study." Asian Journal of Medical Sciences 7, no. 1 (2015): 96–100. http://dx.doi.org/10.3126/ajms.v7i1.12869.

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Background: Stress-related disorders encompass a broad array of conditions, including psychological disorders such as depression and anxiety etc. Among healthcare professionals, nurses have been found to be most prone to burnout.Aims and Objective: 1) To find out the prevalence of recent stress among staff nurses in terms of somatic symptoms, anxiety, social dysfunction and depression and; 2) To find out the association between these psychiatric outcomes and various socio-demographic variables, inter-personal relationships, working environment and professional stress.Materials and Methods: Ins

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