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Journal articles on the topic 'Psychosis-like effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Euba, O., E. Zallo, M. Torreblanca, A. Arroita, N. Sánchez, and A. Barreiro. "Postraumatic Psychosis. Clinical Features." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71146-0.

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Aims:Traumatic brain injury (TBI) cause a wide range of after-effects, including psychiatric disorders. Psychosis although uncommon is a very serious consequences with important functional, therapeutical and legal implications.Methods:Our work is based on a systemic review of the articles published related to TBI and psychosis.Results and conclusions:Delirious psychosis are twice more common than schizophrenia-like psychosis (28% to 14%).Delusions and hallucinations are predominant over passive phenomena or negative symptoms.Evolution and chronicity of postraumatic psychosis depends on the sev

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van Amsterdam, Jan, Tibor Brunt, and Wim van den Brink. "The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects." Journal of Psychopharmacology 29, no. 3 (2015): 254–63. http://dx.doi.org/10.1177/0269881114565142.

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Meyhöfer, Inga, Veena Kumari, Antje Hill, Nadine Petrovsky, and Ulrich Ettinger. "Sleep deprivation as an experimental model system for psychosis: Effects on smooth pursuit, prosaccades, and antisaccades." Journal of Psychopharmacology 31, no. 4 (2016): 418–33. http://dx.doi.org/10.1177/0269881116675511.

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Current antipsychotic medications fail to satisfactorily reduce negative and cognitive symptoms and produce many unwanted side effects, necessitating the development of new compounds. Cross-species, experimental behavioural model systems can be valuable to inform the development of such drugs. The aim of the current study was to further test the hypothesis that controlled sleep deprivation is a safe and effective model system for psychosis when combined with oculomotor biomarkers of schizophrenia. Using a randomized counterbalanced within-subjects design, we investigated the effects of 1 night

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Barkus, E., and S. Lewis. "Schizotypy and psychosis-like experiences from recreational cannabis in a non-clinical sample." Psychological Medicine 38, no. 9 (2008): 1267–76. http://dx.doi.org/10.1017/s0033291707002619.

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BackgroundThe relationship between cannabis use and psychosis is still a matter for debate. Accounting for the individual differences in subjective experiences to recreational cannabis use in the general population may hold some clues to the aetiological relationship between cannabis and psychotic symptoms. We hypothesized that schizotypy would account for the individual differences in subjective experiences after cannabis use but not in patterns of use.MethodIn a sample of 532 young people who had used cannabis at least once, we examined the relationship between the Cannabis Experiences Quest

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Taylor, Hannah E., Suzanne L. K. Stewart, Graham Dunn, Sophie Parker, David Fowler, and Anthony P. Morrison. "Core Schemas across the Continuum of Psychosis: A Comparison of Clinical and Non-Clinical Groups." Behavioural and Cognitive Psychotherapy 42, no. 6 (2013): 718–30. http://dx.doi.org/10.1017/s1352465813000593.

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Background: Research suggests that core schemas are important in both the development and maintenance of psychosis. Aims: The aim of the study was to investigate and compare core schemas in four groups along the continuum of psychosis and examine the relationships between schemas and positive psychotic symptomatology. Method: A measure of core schemas was distributed to 20 individuals experiencing first-episode psychosis (FEP), 113 individuals with “at risk mental states” (ARMS), 28 participants forming a help-seeking clinical group (HSC), and 30 non-help-seeking individuals who endorse some p

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Solmaz, Volkan, Dursun Delibas, Sema Inanir, and Oytun Erbas. "Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats." Journal of Mood Disorders 5, no. 3 (2015): 120. http://dx.doi.org/10.5455/jmood.20150714014531.

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Shin, E. J., J. M. Kim, X. K. T. Nguyen, et al. "Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice." Current Neuropharmacology 9, no. 1 (2011): 247–50. http://dx.doi.org/10.2174/157015911795017263.

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Bersani, Giuseppe, Pietropaolo Marino, Giuseppe Valeriani, et al. "Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant." Case Reports in Psychiatry 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/926395.

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Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, i

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Barrantes-Vidal, Neus, Manel Monsonet, Anna Racioppi, and Thomas R. Kwapil. "M2. STRESS IS ASSOCIATED AND PREDICTS SCHIZOTYPIC AND PSYCHOTIC-LIKE EXPERIENCES IN THE FLOW OF DAILY LIFE IN NONCLINICAL AND INCIPIENT PSYCHOSIS INDIVIDUALS." Schizophrenia Bulletin 46, Supplement_1 (2020): S133. http://dx.doi.org/10.1093/schbul/sbaa030.314.

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Abstract Background Daily-life stressors, specially of a social nature, seem to play an important role in the origin and expression of the continuum of psychosis vulnerability. This study examined whether social stress and social positive appraisals in daily-life were associated, respectively, with the occurrence and the decrease of momentary psychotic-like and paranoid experiences and symptoms across the psychosis continuum. Methods Both social stressors and positive appraisals, as well as psychotic and paranoid experiences, were collected by means of Experience Sampling Methodology over a we

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Tortelli, Andrea, Aurélie Nakamura, Federico Suprani, et al. "Subclinical psychosis in adult migrants and ethnic minorities: systematic review and meta-analysis." BJPsych Open 4, no. 6 (2018): 510–18. http://dx.doi.org/10.1192/bjo.2018.68.

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BackgroundIt is well established that migration and ethnic minority status are risk factors for psychotic disorders. Recent studies have aimed to determine if they are also associated with subclinical psychosis (psychotic-like experiences and schizotypal traits).AimsWe aimed to determine to what extent migrant and ethnic minority groups are associated with higher risk of subclinical psychosis.MethodWe conducted a systematic review, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, and examined findings by ethnicity, migrant status, outcomes of subclinical

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Carhart-Harris, R. L., M. Kaelen, M. Bolstridge, et al. "The paradoxical psychological effects of lysergic acid diethylamide (LSD)." Psychological Medicine 46, no. 7 (2016): 1379–90. http://dx.doi.org/10.1017/s0033291715002901.

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BackgroundLysergic acid diethylamide (LSD) is a potent serotonergic hallucinogen or psychedelic that modulates consciousness in a marked and novel way. This study sought to examine the acute and mid-term psychological effects of LSD in a controlled study.MethodA total of 20 healthy volunteers participated in this within-subjects study. Participants received LSD (75 µg, intravenously) on one occasion and placebo (saline, intravenously) on another, in a balanced order, with at least 2 weeks separating sessions. Acute subjective effects were measured using the Altered States of Consciousness ques

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Taylor, Hannah E., Sophie Parker, Warren Mansell, and Anthony P. Morrison. "Effects of Appraisals of Anomalous Experience on Distress in People at Risk of Psychosis." Behavioural and Cognitive Psychotherapy 41, no. 1 (2012): 24–33. http://dx.doi.org/10.1017/s1352465812000227.

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Background: A cognitive model of psychosis suggests that appraisals of psychotic-like experiences (PLEs), and the subsequent responses adopted, are responsible for the maintenance of distress and disability associated with psychosis. Aims: This study aimed to investigate whether it is possible to manipulate appraisals of an anomalous experience in people at risk of psychosis and whether this affects levels of distress. Method: Participants who had experienced an “at risk mental state” (ARMS) within the past year, were randomized to one of two groups and received either negative or neutral info

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Morgan, Celia J. A., and H. Valerie Curran. "Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis." British Journal of Psychiatry 192, no. 4 (2008): 306–7. http://dx.doi.org/10.1192/bjp.bp.107.046649.

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SummaryCannabis contains various cannabinoids, two of which have almost opposing actions: δ9-tetrahydrocannabinol (Δ9-THC) is psychotomimetic, whereas cannabidiol (CBD) has antipsychotic effects. Hair samples were analysed to examine levels of Δ9-THC and CBD in 140 individuals. Three clear groups emerged: ‘THC only’, ‘THC+CBD’ and those with no cannabinoid in hair. The THC only group showed higher levels of positive schizophrenia-like symptoms compared with the no cannabinoid and THC+CBD groups, and higher levels of delusions compared with the no cannabinoid group. This provides evidence of th

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Freeman, Abigail M., Claire Mokrysz, Chandni Hindocha, et al. "Does variation in trait schizotypy and frequency of cannabis use influence the acute subjective, cognitive and psychotomimetic effects of delta-9-tetrahydrocannabinol? A mega-analysis." Journal of Psychopharmacology 35, no. 7 (2021): 804–13. http://dx.doi.org/10.1177/0269881120959601.

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Background: While the acute effects of cannabis are relatively benign for most users, some individuals experience significant adverse effects. This study aimed to identify whether variation in schizotypal personality traits and frequency of cannabis use influence the acute effects of delta-9-tetrahydrocannabinol (THC). Methods: Individual participant data from four double-blind, randomised, placebo-controlled, acute crossover studies involving 128 cannabis users were combined for a mega-analysis. Using multilevel linear models and moderation analyses, frequency of cannabis use and schizotypal

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Mason, Oliver J. "Inducing Psychotic-like Experiences without Drugs using the Witches’ Cradle." Journal of Medical Psychology 1, no. 1 (2020): 53–56. http://dx.doi.org/10.3233/jmp-190020.

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Various means of inducing unusual or anomalous experiences sharing similarities with psychosis have been proposed. In the present study, an ‘altered states of consciousness induction device’ (ASCID) or ‘witches’ cradle’ was used to suspend 81 participants for a short duration. The Psychotomimetic States Inventory recorded an increase in a wide variety of experiences following the cradle when compared to baseline. Psychotic-like experiences were predicted by greater positive schizotypal trait scores. Anomalous proprioceptive perceptual input appears to be capable for some individuals of inducin

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Ashinoff, Brandon, and Guillermo Horga. "Evidence-Order Effects in Probabilistic Inference: Recency Bias and Delusion-Like Ideation Across the Psychosis Continuum." Biological Psychiatry 87, no. 9 (2020): S392—S393. http://dx.doi.org/10.1016/j.biopsych.2020.02.1004.

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Cortes-Briones, Jose A., John D. Cahill, Patrick D. Skosnik та ін. "The Psychosis-like Effects of Δ9-Tetrahydrocannabinol Are Associated With Increased Cortical Noise in Healthy Humans". Biological Psychiatry 78, № 11 (2015): 805–13. http://dx.doi.org/10.1016/j.biopsych.2015.03.023.

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Obayi, Okwudili N. K. "Acute schizophrenia-like psychotic disorder associated with immunosuppressive agent use three years after renal transplantation: a case report." International Journal of Scientific Reports 4, no. 7 (2018): 192. http://dx.doi.org/10.18203/issn.2454-2156.intjscirep20182731.

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<p class="abstract">Tacrolimus is a potent immunosuppressive agent used to prevent graft-versus-host disease after organ transplantation. Though a beneficial drug that contributes in the post-transplant life of patients, it comes with various side effects including, though rarely, psychiatric manifestations such as psychosis.<strong> </strong>Reported here is the case of a 21 year old lady with no prior psychiatry history with apparent tacrolimus-induced schizophrenia-like psychosis. Withdrawal of the immunosuppressant led her to full recovery from the mental problem. To the

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van der Feltz-Cornelis, Cm. "Treatment of interictal psychiatric disorder in epilepsy. II. Chronic psychosis." Acta Neuropsychiatrica 14, no. 1 (2002): 44–48. http://dx.doi.org/10.1034/j.1601-5215.2002.140107.x.

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Background:Interictal psychosis is a serious comorbid condition in epilepsy patients that would benefit from treatment with psychotropic medication.Objective:This paper gives an overview of the pathophysiology, symptomatology and treatment of the schizophrenia-like psychosis of epilepsy. Use of the term ‘interictal chronic psychosis’ is suggested, to conform to current DSM-IV classification of schizophrenia.Methods:Literature review supplemented by clinical experience. There is a lack of randomized control trials (RCTs) concerning effectiveness and side-effects of neuroleptics in epilepsy pati

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Grant, Phillip, Aisha Judith Leila Munk, Yvonne Kuepper, Catrin Wielpuetz, and Juergen Hennig. "Additive Genetic Effects for Schizotypy Support a Fully-Dimensional Model of Psychosis-Proneness." Journal of Individual Differences 36, no. 2 (2015): 87–92. http://dx.doi.org/10.1027/1614-0001/a000155.

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Schizotypy is an organization of traits mirroring psychosis-like symptoms and conveying individual psychosis-proneness. Schizotypy and schizophrenia share a genetic basis, wherefore initial schizotypy definitions considered a schizophrenic genotype as a condicio sine qua non. Since the search for a monogenetic schizotypy marker has proven in vain, it is believed that schizotypy is (genetically) based on multiple alleles, each of small effect-size. Schizophrenia may be viewed as a qualitative entity at the extreme of the schizotypy dimension. To date, however, it has not been shown that effects

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Ebert, Dieter, Roland Albert, Albrecht May, et al. "The serotonin syndrome and psychosis-like side-effects of fluvoxamine in clinical use – an estimation of incidence." European Neuropsychopharmacology 7, no. 1 (1997): 71–74. http://dx.doi.org/10.1016/s0924-977x(96)00043-0.

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Reeves, S., R. Stewart, and R. Howard. "Service contact and psychopathology in very-late-onset schizophrenia-like psychosis: the effects of gender and ethnicity." International Journal of Geriatric Psychiatry 17, no. 5 (2002): 473–79. http://dx.doi.org/10.1002/gps.614.

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Scott, Daniel, and Carol A. Tamminga. "Effects of genetic and environmental risk for schizophrenia on hippocampal activity and psychosis-like behavior in mice." Behavioural Brain Research 339 (February 2018): 114–23. http://dx.doi.org/10.1016/j.bbr.2017.10.039.

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Ganesh, Suhas, Jose Cortes-Briones, Mohini Ranganathan, Rajiv Radhakrishnan, Patrick D. Skosnik, and Deepak Cyril D’Souza. "Psychosis-Relevant Effects of Intravenous Delta-9-Tetrahydrocannabinol: A Mega Analysis of Individual Participant-Data from Human Laboratory Studies." International Journal of Neuropsychopharmacology 23, no. 9 (2020): 559–70. http://dx.doi.org/10.1093/ijnp/pyaa031.

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Abstract Introduction There is increasing interest in the relationship between cannabinoids and psychosis. While individual human laboratory studies have been critical in demonstrating that cannabinoids (e.g., delta-9-tetrahydrocannabinol [THC]) can induce acute transient psychosis-like effects in healthy human volunteers, combining data from multiple studies offers a fine-grained view of these effects. Methods THC-induced psychosis-relevant effects were examined using a data repository of 10 double-blind, randomized, placebo-controlled, crossover studies with 400 i.v. THC infusions in healthy

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Morgan, C. J. A., C. Gardener, G. Schafer, et al. "Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being." Psychological Medicine 42, no. 2 (2011): 391–400. http://dx.doi.org/10.1017/s0033291711001322.

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BackgroundCannabis varies considerably in levels of its two major constituent cannabinoids – (delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Recently, we found evidence that those who smoked cannabis containing detectable levels of CBD had fewer psychotic-like symptoms than those whose cannabis had no CBD. The present study aimed, first, to replicate those findings and, second, to determine whether protective effects of CBD may extend to other harms of cannabis, such as memory impairment and reduced psychological well-being.MethodA total of 120 current cannabis smokers, 66 daily use

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Tsopelas, C., M. Dimitraka, P. Ntounas, A. Gatos-Gatopoulos, D. Karadima, and T. Charalampos. "Use of cannabis components in the treatment of mental disorders." European Psychiatry 33, S1 (2016): S552. http://dx.doi.org/10.1016/j.eurpsy.2016.01.2036.

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IntroductionThere is evidence that supports the increased risk of developing psychosis or psychotic like symptoms in vulnerable populations after use of cannabis. Cannabis’ main psychoactive component, Δ9-tetrahydrocannabinol (THC), induces acute psychotic effects and cognitive impairment. But there is also evidence to suggest that molecules in the cannabis plant could have an antipsychotic affect.AimsIn this review we are trying to explore the possibilities of cannabis use as a therapeutic agent in mental disorders.MethodsThorough research of the main databases, and web search engines for rel

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Kilciksiz, Can, and John Torous. "T105. VERBAL MEMORY MEASUREMENT TOWARDS DIGITAL PERSPECTIVES IN FIRST-EPISODE PSYCHOSIS: A SYSTEMATIC REVIEW STUDY." Schizophrenia Bulletin 46, Supplement_1 (2020): S270—S271. http://dx.doi.org/10.1093/schbul/sbaa029.665.

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Abstract Background Psychosis is a clinical syndrome which can have detrimental effects on patients in different aspects of functioning such as thought, behavior, and cognition. Even in early phases psychotic spectrum illnesses like schizophrenia, patients can experience cognitive decline prior to overt classical symptoms like delusions and hallucinations. Early detection and reducing the duration of untreated psychosis through early intervention can prevent or slow the progress of cognitive symptoms and the entire illness. Although cognition research in early psychosis has demonstrated that v

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Radhika Tyagi, Sangrila Singh, Anjali Joshi, Vishali Chopra, Priyank Vyas, and Amit Gupta. "Overview of Salvia divinorum –Substance-induced psychosis." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1714–18. http://dx.doi.org/10.26452/ijrps.v11ispl4.4360.

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As per the literature, humans ingest a comprehensive range of food materials including drugs along with dietary supplements which are mainly derived through medicinal plant products and modifying the purpose of the central nervous system (CNS). These psychoactive based properties are mainly attributable to the existence of plant-derived secondary metabolites. Most of the cases or studies showed the effects of these phytochemicals derived from secondary metabolites on the human CNS might be linked either to their ecological roles or molecular along with biochemical based properties are reported

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Howard, Robert, Elizabeth Cort, Rosie Bradley, et al. "Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT." Health Technology Assessment 22, no. 67 (2018): 1–62. http://dx.doi.org/10.3310/hta22670.

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Background Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment. Objectives The study investigated whether or not low-dose amisulpride is superior to placebo in reducing psychosis symptoms over 12 weeks and if any benefit is maintained by continuing treatment thereafter. Treatment safety and cost-effectiveness were also investigated. Design Three-arm, parallel-group, placebo-controlled, double-blind, randomi

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Stramecki, Filip, Dorota Frydecka, Łukasz Gawęda, et al. "The Impact of the FKBP5 Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults." Brain Sciences 11, no. 5 (2021): 561. http://dx.doi.org/10.3390/brainsci11050561.

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Common variations of the FKBP5 gene are implicated in psychotic disorders, by modulating the hypothalamic–pituitary–adrenal axis reactivity to stress. It has been demonstrated that some of them might moderate the effects of childhood trauma on psychosis proneness. However, these associations have not been investigated with respect to traumatic life events (TLEs). Therefore, we aimed to explore whether the FKBP5 polymorphisms moderate the effects of TLEs on the level of psychotic-like experiences (PLEs). A total of 535 non-clinical adults were approached for participation, and genotyping of six

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Irankunda, Pacifique, and Laurie Heatherington. "Mental health treatment outcome expectancies in Burundi." Transcultural Psychiatry 54, no. 1 (2016): 46–65. http://dx.doi.org/10.1177/1363461516652302.

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Best practices in global mental health stress the importance of understanding local values and beliefs. Research demonstrates that expectancies about the effectiveness of a given treatment significantly predicts outcome, beyond the treatment effect itself. To help inform the development of mental health interventions in Burundi, we studied expectancies about the effectiveness of four treatments: spiritual healing, traditional healing, medication, and selected evidence-based psychosocial treatments widely used in the US. Treatment expectancies were assessed for each of three key syndromes ident

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Ciufolini, Simone, Matthew Kempton, Charlotte Gayer-Anderson, et al. "S186. THE EFFECTS OF CHILDHOOD TRAUMA ON HIPPOCAMPAL VOLUME IN FIRST EPISODE PSYCHOSIS: DOES CORTISOL PLAY A ROLE?" Schizophrenia Bulletin 46, Supplement_1 (2020): S109. http://dx.doi.org/10.1093/schbul/sbaa031.252.

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Abstract Background Childhood trauma is one of the most important risk factors in psychosis. Mounting evidence is associating early trauma exposure with alterations in stress sensitive areas, like the hippocampus, and abnormal concentrations of the main stress hormone, cortisol. As hippocampus is a pivotal brain region in the hypothalamus–pituitary–adrenal (HPA) axis regulation of cortisol, better understanding the relationship between childhood trauma, hippocampus structure and cortisol concentration would help clarify how childhood trauma exposure can increase the risk of developing psychosi

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Kostic, Velimir, Maja Jovanovic, Jelena Radovic, and Stevan Vujic. "Side effects of antiviral therapy in patients with chronic hepatitis C infection." Medical review 65, no. 3-4 (2012): 106–10. http://dx.doi.org/10.2298/mpns1204106k.

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Introduction. Chronic hepatitis C currently represents a global health problem, which is expected to be reduced by pegylated-interferon and ribavirin therapy. Material and Methods. We examined 88 patients with chronic hepatitis C, divided into three groups according to their comorbidity: the patients without comorbidity were in group I, group II included the patients on dialysis, and group III included the patients with hemophilia. Results. A significant difference was found in the percentage of achieved sustained virological response between the patients on dialysis and other patients, p<0

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Colizzi, Marco, Nathalie Weltens, Philip McGuire, et al. "Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis." Molecular Psychiatry 25, no. 12 (2019): 3231–40. http://dx.doi.org/10.1038/s41380-019-0374-8.

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AbstractThe neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie the association, direct evidence that cannabis use affects either acute or chronic striatal dopamine is inconclusive. In contrast, pre-clinical research suggests that cannabis may affect dopamine via modulation of glutamate signaling. A double-blind, randomized, placebo-controlled, crossover design was used to investigate whether altered striatal glutamate, as measured using

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Ermakova, Anna O., Nimrod Gileadi, Franziska Knolle, et al. "Cost Evaluation During Decision-Making in Patients at Early Stages of Psychosis." Computational Psychiatry 3 (August 2019): 18–39. http://dx.doi.org/10.1162/cpsy_a_00020.

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Jumping to conclusions during probabilistic reasoning is a cognitive bias reliably observed in psychosis and linked to delusion formation. Although the reasons for this cognitive bias are unknown, one suggestion is that psychosis patients may view sampling information as more costly. However, previous computational modeling has provided evidence that patients with chronic schizophrenia jump to conclusions because of noisy decision-making. We developed a novel version of the classical beads task, systematically manipulating the cost of information gathering in four blocks. For 31 individuals wi

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Correia, Banny Silva Barbosa, João Victor Nani, Raniery Waladares Ricardo, et al. "Effects of Psychostimulants and Antipsychotics on Serum Lipids in an Animal Model for Schizophrenia." Biomedicines 9, no. 3 (2021): 235. http://dx.doi.org/10.3390/biomedicines9030235.

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Schizophrenia (SCZ) treatment is essentially limited to the use of typical or atypical antipsychotic drugs, which suppress the main symptoms of this mental disorder. Metabolic syndrome is often reported in patients with SCZ under long-term drug treatment, but little is known about the alteration of lipid metabolism induced by antipsychotic use. In this study, we evaluated the blood serum lipids of a validated animal model for SCZ (Spontaneously Hypertensive Rat, SHR), and a normal control rat strain (Normotensive Wistar Rat, NWR), after long-term treatment (30 days) with typical haloperidol (H

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Antoniades, Mathilde, Igor Nenadic, Tilo Kircher, et al. "M156. CORTICAL NEUROANATOMICAL SIGNATURE OF SCHIZOTYPY IN 2,695 INDIVIDUALS ASSESSED IN A WORLDWIDE ENIGMA STUDY." Schizophrenia Bulletin 46, Supplement_1 (2020): S195. http://dx.doi.org/10.1093/schbul/sbaa030.468.

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Abstract Background Cortical neuroanatomical abnormalities have been reported along a continuum between individuals with chronic schizophrenia, first-episode psychosis, clinical high risk for psychosis, and healthy individuals self-reporting subclinical psychotic-like experiences (or schizotypy). Recently, the Schizophrenia Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium provided meta-analytic evidence for robust cortical thickness abnormalities in schizophrenia, while also indicating that these abnormalities are influenced by illness severit

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Inta, D., J. Lima, D. Filipovic, G. Köhr, R. Sprengel, and P. Gass. "C-Fos brain mapping of global and subunit-specific NMDA receptor antagonists: Relevance for their potential use as antidepressants." European Psychiatry 26, S2 (2011): 639. http://dx.doi.org/10.1016/s0924-9338(11)72345-8.

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IntroductionNMDA receptor antagonists as ketamine represent fast-acting alternatives to monoaminergic-based antidepressants. Major drawbacks of these drugs are psychosis-like states and cortical neurotoxicity, effects correlating with potent activation of the cingulated and retrosplenial cortex. The molecular mechanisms underlying these side-effects have not been deciphered yet.AimsWe aimed to determine potential molecular components of the NMDA receptor implicated in their psychotomimetic action and investigated whether subunit-specific NMDA receptor antagonists also induce similar neurotoxic

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Ruhrmann, S. "Intervention in Clinical High Risk States - Current Status and Future Perspectives." European Psychiatry 41, S1 (2017): S27—S28. http://dx.doi.org/10.1016/j.eurpsy.2017.01.140.

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IntroductionDuring the last twenty years, international efforts advanced the prevention of psychosis considerably. However, improved predictions as well as well-tolerated and needs-tailored interventions are still required.ObjectivesPrediction and Prevention of PsychosisAims Presenting the current state and new developments, including the European Union funded multi-center project PRONIA with regard to prediction (www.pronia.eu, 7th Framework Programme grant agreement n° 602152) and the German multi-center trial ESPRIT funded by the Federal Ministry of Education and Research (BMBF grants 01EE1

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Smigielski, Lukasz, Diana Wotruba, Valerie Treyer, et al. "The Interplay Between Postsynaptic Striatal D2/3 Receptor Availability, Adversity Exposure and Odd Beliefs: A [11C]-Raclopride PET Study." Schizophrenia Bulletin 47, no. 5 (2021): 1495–508. http://dx.doi.org/10.1093/schbul/sbab034.

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Abstract Background Between unaffected mental health and diagnosable psychiatric disorders, there is a vast continuum of functioning. The hypothesized link between striatal dopamine signaling and psychosis has guided a prolific body of research. However, it has been understudied in the context of multiple interacting factors, subclinical phenotypes, and pre-postsynaptic dynamics. Method This work investigated psychotic-like experiences and D2/3 dopamine postsynaptic receptor availability in the dorsal striatum, quantified by in vivo [11C]-raclopride positron emission tomography, in a sample of

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Daniel, Christina, and Oliver J. Mason. "Predicting Psychotic-Like Experiences during Sensory Deprivation." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/439379.

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Aims. This study aimed to establish the contribution of hallucination proneness, anxiety, suggestibility, and fantasy proneness to psychotic-like experiences (PLEs) reported during brief sensory deprivation.Method. Twenty-four high and 22 low hallucination-prone participants reported on PLEs occurring during brief sensory deprivation and at baseline. State/trait anxiety, suggestibility, and fantasy proneness were also measured.Results. Both groups experienced a significant increase in PLEs in sensory deprivation. The high hallucination prone group reported more PLEs both at baseline and in sen

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Thomas, Robert J., and David R. Reagan. "Association of a Tourette-Like Syndrome with Ofloxacin." Annals of Pharmacotherapy 30, no. 2 (1996): 138–41. http://dx.doi.org/10.1177/106002809603000205.

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OBJECTIVE: To describe the association between the use of the fluoroquinolone ofloxacin in an elderly man and an unusual acute encephalopathy with characteristics suggestive of Tourette's syndrome. CASE SUMMARY: An unusual syndrome was observed in a 71-year-old man temporally related to the initiation of ofloxacin therapy that resolved completely after discontinuation of the drug. The most remarkable phenomena were spitting and profuse swearing; other features were echolalia, echopraxia, orofacial and limb automatisms, hypersalivation, and amnesia for the episode on recovery. The clinical synd

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de Castro-Catala, Marta, Neus Barrantes-Vidal, Tamara Sheinbaum, Artal Moreno-Fortuny, Thomas R. Kwapil, and Araceli Rosa. "COMT-by-Sex Interaction Effect on Psychosis Proneness." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/829237.

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Schizotypy phenotypes in the general population share etiopathogenic mechanisms and risk factors with schizophrenia, supporting the notion of psychosis as a continuum ranging from nonclinical to clinical deviance. Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex. Several recent studies have reported a sex difference in the impact of COMT genotype on psychiatric and cognitive phenotypes and personality traits. The present study investigated the association of COMT Val158Met (rs4680) w

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Uzuneser, Taygun C., Eva-Maria Weiss, Jana Dahlmanns, et al. "Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats." Journal of Psychopharmacology 35, no. 1 (2020): 65–77. http://dx.doi.org/10.1177/0269881120965908.

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Background: The therapeutic effects of antipsychotic drugs (APDs) are mainly attributed to their postsynaptic inhibitory functions on the dopamine D2 receptor, which, however, cannot explain the delayed onset of full therapeutic efficacy. It was previously shown that APDs accumulate in presynaptic vesicles during chronic treatment and are released like neurotransmitters in an activity-dependent manner triggering an auto-inhibitory feedback mechanism. Although closely mirroring therapeutic action onset, the functional consequence of the APD accumulation process remained unclear. Aims: Here we t

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Berkhout, Susan, Juveria Zaheer, and Gary Remington. "M246. DIGITAL SELF-MONITORING AND EMBODIMENT IN FIRST EPISODE PSYCHOSIS: ETHICAL CONSIDERATIONS." Schizophrenia Bulletin 46, Supplement_1 (2020): S229—S230. http://dx.doi.org/10.1093/schbul/sbaa030.558.

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Abstract Background Smartphone technology has seen expanding interest across nearly all areas of medicine, including psychiatry, where app-based technologies frequently function as proxies for digitized behavioural phenotypes (Firth and Torous 2015). In the area first episode psychosis especially, there has been a rising interest in the use of digital platforms for patient self-management as well as for assessment of symptom domains (Ben-Zeev et al. 2014; Bell et al. 2018). Methods This paper discusses findings from a 3 year-long ethnographic study carried out within a first episode psychosis

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Evermann, Ulrika, Simon Schmitt, Tina Meller, Julia-Katharina Pfarr, Sarah Grezellschak, and Igor Nenadić. "Distress severity in perceptual anomalies moderates the relationship between prefrontal brain structure and psychosis proneness in nonclinical individuals." European Archives of Psychiatry and Clinical Neuroscience 271, no. 6 (2021): 1111–22. http://dx.doi.org/10.1007/s00406-020-01229-5.

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AbstractIn the general population, psychosis risk phenotypes occur independently of attenuated prodromal syndromes. Neurobiological correlates of vulnerability could help to understand their meaningfulness. Interactions between the occurrence of psychotic-like experiences (PLE) and other psychological factors e.g., distress related to PLE, may distinguish psychosis-prone individuals from those without risk of future psychotic disorder. We aimed to investigate whether (a) correlates of total PLE and distress, and (b) symptom dimension-specific moderation effects exist at the brain structural le

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Andrei, I. A., A. M. Cristache, M. E. Parfene-Banu, et al. "Acute psychosis induced by short-term treatment with methylprednisolone – a case report." European Psychiatry 33, S1 (2016): S626. http://dx.doi.org/10.1016/j.eurpsy.2016.01.2349.

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Steroid treatment has been widely used for immunologic and inflammatory disorders. Psychiatric symptoms are not uncommon complications of the corticosteroid treatment. Correlations between the hypothalamic-pituitary-adrenal (HPA) axis and various psychoses have been already established in the specialty literature (modified HPA activity by drugs or not, glucocorticoid receptors downregulation, reduced hippocampal volume). The prevalence of corticosteroid-induced psychotic disorders varies around 5–6%. Most corticosteroid-induced symptoms start during the first few weeks after treatment initiati

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Satish Kumar Sharma and Suruchi Singh. "A Review on conceptual framework of Drug Side Effects and Pharmacoresistance in Epilepsy." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 378–83. http://dx.doi.org/10.26452/ijrps.v12i1.4030.

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Epileptic seizures in the form of involuntary body movements have made patients’ lives extremely difficult. There are mainly two types of seizures partial or focal seizure affect just one side of the brain and generalised seizures affect the whole brain of a person. The person suffers from neuro-sensory deregulation and consciousness loss, coupled with episodes of seizures. Different drug therapies have been used for epilepsy patients targeting neurotransmitters regulation mechanisms. The drug targets and mechanism of action in polytherapy remain ambiguous. However, 6 out of 10 patients quit a

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Mielnik, Catharine A., Kim S. Sugamori, David B. Finlay, et al. "A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models." Neuropsychopharmacology 46, no. 2 (2020): 413–22. http://dx.doi.org/10.1038/s41386-020-00876-5.

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AbstractThe endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs mediates inhibition of neurotransmitter release and acts as a major homeostatic system. Many aspects of the eCBs are altered in a number of psychiatric disorders including schizophrenia, which is characterized by dysregulation of dopaminergic signaling. The GluN1-Knockdown (GluN1KD) and Dopamine Transporter Knockout (DATKO) mice are models of hyperdopaminergia, which display abnormal psychosis-related behaviors, including hyperlocomotion

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Müller, Christian, Eva-Maria Weiss, Jan Hellmann, et al. "T215. THE ANTIPSYCHOTIC ACTION OF HALOPERIDOL IN PSYCHOTIC-LIKE RATS REQUIRES PRESYNAPTIC VESICULAR ACCUMULATION." Schizophrenia Bulletin 46, Supplement_1 (2020): S314. http://dx.doi.org/10.1093/schbul/sbaa029.775.

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Abstract Background The therapeutic effects of antipsychotic drugs (APDs) are mainly attributed to their post synaptic inhibitory functions on the dopamine D2 receptor, which however, cannot explain the delayed onset of full therapeutic efficacy. It was previously shown that APDs accumulate in presynaptic vesicles during chronic treatment and are released like neurotransmitters in an activity-dependent manner triggering an auto-inhibitory feedback mechanism. Although closely mirroring therapeutic action onset, the functional consequence of the APD accumulation remained unclear. Here we show th

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