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Relevant bibliographies by topics / Pteroylglutamic acid

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Academic literature on the topic 'Pteroylglutamic acid'

Author: Grafiati

Published: 4 June 2025

Last updated: 23 June 2025

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Journal articles on the topic "Pteroylglutamic acid"

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Aldakhil, Taibah, and Ali Altharawi. "Drug Repurposing for the Discovery of Potential Inhibitors Targeting DJ-1 (PARK7) Against Parkinson’s Disease." Crystals 15, no. 3 (2025): 239. https://doi.org/10.3390/cryst15030239.

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Parkinson’s disease (PD) is a neurodegenerative disease characterized by increased movement dysfunction and cognitive loss. DJ-1 (PARK7) is an antioxidant that protects cells from oxidative stress, a major contributor to cellular damage and neurodegeneration in PD. Mutations in the DJ-1 gene reduce its neuroprotective ability contributing to PD onset and progression. The neuroprotective and antioxidant properties of DJ-1 make it a viable therapeutic target for developing novel PD therapeutics. A drug repurposing approach was applied to identify promising inhibitors for DJ-1. Three drugs—droxicam, pteroylglutamic acid, and niraparib—were identified based on their binding affinities and interactions. Further molecular dynamics simulations revealed that niraparib and pteroylglutamic acid were the most stable among the three complexes. Moreover, the binding strength of the complexes was confirmed by MMPBSA binding free energy analysis, with Niraparib (−13.50 kcal/mol) and pteroylglutamic Acid (−11.41 kcal/mol) as the most promising candidates. These results suggest that pteroylglutamic acid and niraparib may serve as useful DJ-1 inhibitors for PD-associated protein DJ-1. Further experimental validation and in vivo assessments are required to confirm the efficacy and safety of these drugs against PD.

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Jensen, Kai Arne, and Kai Schmith. "ANTAGONISM BETWEEN SULFATHIAZOLE AND PTEROYLGLUTAMIC ACID (“FOLIC ACID”)." Acta Medica Scandinavica 131, S213 (2009): 234–37. http://dx.doi.org/10.1111/j.0954-6820.1948.tb15131.x.

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Matte, J. Jacques, and Christiane L. Girard. "Pteroyglutamic (folic) acid in different feedstuffs: the pteroylglutamate content and an attempt to measure the bioavailability in pigs." British Journal of Nutrition 72, no. 6 (1994): 911–22. http://dx.doi.org/10.1079/bjn19940095.

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Sixty piglets selected after weaning at 4 weeks of age were assigned to five replicates of twelve animals each. In each of these replicates the postprandial variations in serum pteroylglutamate after the ingestion of twelve sources of dietary pteroylglutamic acid were recorded twice weekly at 10 and 16 weeks of age. In six of these sources of pteroylglutamic acid the chemically pure form of the vitamin was incorporated into a semi-purified diet at concentrations varying between 0 and 1·0 mg/kg. The six other sources were provided by a soya-bean meal, rapeseed meal, maize, barley, wheat, and a commercial vitamin premix. The concentrations of pteroylglutamates measured by radioimmunoassay in the different feedstuffs were, in most cases, far from the values reported in the literature, except for maize. Indeed, while total pteroylglutamates in barley, wheat and rapeseed meal were lower by 35–56%. 17–50% and 60% respectively compared with references values, the corresponding values for soya-bean meal ranged from one third to twice as much. The area under the curve (AUC) of the pre- and postprandial (1, 2, 3, 5 and 7 h) serum pteroylglutamate following ingestion of increasing levels of chemically pure pteroylmono- glutamic acid was used to derive a regression for the 100% bioavailability of dietary pteroylglutamic acid. The corresponding AUC for the feedstuff sources of pteroylglutamates were used in the regression to determine the proportion of bioavailable pteroylglutamates out of total pteroylglutamates measured in these ingredients. No relationship (P0·66) was found between the level of chemically pure dietary pteroylmonoglutamic acid and the postprandial AUC. In fact, there was no significant (P0·11) increase in the postprandial concentration of serum pteroylglutamate for any of the pteroylglutamate sources used except for wheat. Moreover, values tended (P0·08) to be lower at 5 and 7 h postfeeding except for wheat and barley. It was hypothesized that this decrease is probably linked to the postfeeding variation in bile secretion which drains considerable amounts of circulatory pteroylglutamates. The results of the present experiment indicate that further research on analytical procedure is needed in order to provide a reliable method for measuring concentrations of pteroylglutamic acid in different sources of a given feedstuff used in pig feeding. In addition to this analytical concern, the measurement of the proportion of bioavailable pteroylglutamic acid in feedstuffs for pigs using postprandial variations of serum pteroylglutamates appears to be technically hazardous.

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Dueker, Stephen R., A. Daniel Jones, Gary M. Smith, and Andrew J. Clifford. "Preparation of [2′,3′,5′,6′-2H4]pteroylglutamic acid." Journal of Labelled Compounds and Radiopharmaceuticals 36, no. 10 (1995): 981–91. http://dx.doi.org/10.1002/jlcr.2580361010.

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Matthews, J. H. "Cyanocobalamin [c-lactam] Inhibits Vitamin B12 and Causes Cytotoxicity in HL60 Cells: Methionine Protects Cells Completely." Blood 89, no. 12 (1997): 4600–4607. http://dx.doi.org/10.1182/blood.v89.12.4600.

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Abstract The [c-lactam] derivative of cobalamin antagonizes vitamin B12 in vivo. Therefore, we investigated its effects in tissue culture to develop a model in which to study vitamin B12-deficient hemopoiesis. HL60 cells were cultured in medium containing either methionine or L-homocysteine thiolactone, and various concentrations of 5-methyltetrahydrofolate or pteroylglutamic acid. In medium with L-homocysteine thiolactone, 5-methyltetrahydrofolate, and dialyzed serum, cyanocobalamin [c-lactam] caused cell death, reversible by additional vitamin B12 . Pteroylglutamic acid did not prevent this cytotoxic effect. Methionine completely protected cells against cyanocobalamin [c-lactam] for periods of up to 4 months of culture, irrespective of the folate source. Cyanocobalamin [c-lactam] reversibly impaired the incorporation of 5-[14CH3]-tetrahydrofolate and [1-14C] propionic acid by intact cells, consistent with inhibition of methionine synthase and methylmalonyl-CoA mutase. A substantial proportion of 5-[14CH3]-tetrahydrofolate uptake could not be suppressed by methionine and may, therefore, have occurred outside of the methionine synthase pathway. These findings are the first indication that cyanocobalamin [c-lactam] antagonizes vitamin B12 in vitro and causes cell death from methionine deficiency. The model should be valuable for investigating the biochemical pathology of vitamin B12-deficient hemopoiesis. The results suggest that methylfolate is not trapped when methionine synthase is inhibited in HL60 cells, but they do not disprove the methylfolate trap hypothesis as applied to normal blood cells.

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Sahar, Saniya. "Role of Folate and Folic Acid During Pregnancy." International Journal for Research in Applied Science and Engineering Technology 9, no. 12 (2021): 1488–92. http://dx.doi.org/10.22214/ijraset.2021.39295.

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Abstract: Pregnancy represents a period of fast tissue growth of maternal and foetal tissues that's related to enhanced energy and nutrient needs. Maternal nutrition throughout gestation period, has being essential for best offspring development, reducing long unwellness burden and for general health throughout life. Maternal Folate throughout pregnancy might have numerous roles in offspring health, as well as neurodevelopment and psychological feature performance in childhood. Folate is crucial for C1 metabolism, a network of pathways concerned in many biological processes as well as nucleotide synthesis, deoxyribonucleic acid repair and methylation reactions. The periconceptional use of pteroylglutamic acid (Folic Acid ) containing supplements reduces the primary incidence, as well as recurrence of neural tube defects. Folic Acid (FA) are artificial form of a necessary vitamin generically considered Folates or B9. It is concerned in one-carbon metabolism, and it's been connected to lowering neural tube Defect (NTD). National programs to mandate fortification of food with Folic Acid have reduced the prevalence of NTDs worldwide . The indisputable protecting role of Folic Acid in the hindrance of NTD, in addition to the low compliance of women to Folic Acid recommendations, has aroused the choice of mandatory Folic Acid fortification, a policy currently in place in over eighty countries worldwide. Mandatory food fortification needs food makers to feature Folic Acid to certain foods (e.g. starch or grain products), whereas voluntary fortification permits Folic Acid to be added to foods at the discretion of manufacturers. Food fortification with Folic Acid because the intervention is likely to achieve increasing Folic Acid intake among populations throughout the world. The objective of this article is to discuss the Role of Folic Acid and Folate during pregnancy and to review the role of Folate and Folic Acid , metabolism , absorption and Folic Acid effects on maternal on the basis of recent findings that are important for implementation of fortified food to design future studies. Keywords: Neurodevelopment, Methylation Reactions, Pteroylglutamic Acid, Bioavailability, Monoglutamates.

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Forrester, M. B. "Folic acid calls to poison centers in Texas, 1998–2003." Human & Experimental Toxicology 24, no. 8 (2005): 423–27. http://dx.doi.org/10.1191/0960327105ht547oa.

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Folic acid (folacin, pteroylglutamic acid) is a mono-glutamate form of the water-soluble B vitamin that is involved in the synthesis of nucleotides and amino acids and the normal maturation of red blood cells. This study describes the folic acid calls received by Texas poison centers during 1998–2003. There were 650 calls involving folic acid as a single-ingredient product, of which 55.1% were human exposures. Children age B / 6 years accounted for 80.1% of the human exposures. Patients were managed outside of the health care facilities in 92.1% of the cases. Of those cases with a known medical outcome, 94.8% had no clinical effects. This study found folic acid exposures reported to poison centers were unlikely to have more than minor adverse affects.

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NIEWEG, H. O., F. S. P. BUCHEM, and W. F. STENFERT KROESE. "Vitamin B12 and Pteroylglutamic Acid in the Treatment of Megaloblastic Anemias." Acta Medica Scandinavica 142, no. 1 (2009): 45–63. http://dx.doi.org/10.1111/j.0954-6820.1952.tb13842.x.

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Olena, Kovaliova, Tchursinov Yuriy, Kalyna Viktoriia, Khromenko Tatyana, and Kunitsia Ekaterina. "INVESTIGATION OF THE INTENSIVE TECHNOLOGY OF FOOD SPROUTS USING ORGANIC ACIDS." EUREKA: Life Sciences 2 (March 31, 2020): 45–53. https://doi.org/10.21303/2504-5695.2020.001204.

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The features of the intensive technology of getting food sprouts with organic acids as an intensifier of germination were studied. The aim was to establish the features of the intensive technology of producing sprouts of different crops with using organic acids at germination (butanedioic, 3-pyridine carbonic, pteroylglutamic). It is important to search new and safe germination stimulators of universal use. Such substances are just the studied organic acids, because positive changes of quality parameters of a ready product are traced at their use in the sprout technology. There was studied the sprout technologies that includes washing, disinfection, step-by-step air-water soaking of grains from different crops and their germination. As a disinfectant and growth stimulator at the stage of grain material soaking, there were used water solutions of the organic acids in the concentration diapason from 0.025 to 2.5 g/l. Due to their use, it became possible to get high-quality healthy food products, namely sprouts of different crops. Organic acid solutions stimulate the germination process and allow to get an essentially higher amount of high-quality sprouts in shorter terms without chemical toxic admixtures. The research results of the influence of the mentioned organic acids on germination indices of different grains materials are presented. Optimal values of concentrations of active substances in solutions have been established. Comparing with the classic technology of using these acids as a growth stimulator for sprouts allows to decrease the total duration of material germination in 1.5–2 times. Due to that it becomes possible to initiate the industrial production of sprouts. The experimental studies proved the effectiveness of using organic acids at getting living sprouts. It is demonstrated, that their use allows not only to intensify grains germination, but also favors more active formation of sprouts. The presented technology of producing sprouts of different crops is innovative. The obtained grain raw materials may be used independently or as an important component of new food products.

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Jacoby, Bart T., and Franklin T. Henry. "Liquid Chromatographic Determination of Folic Acid in Infant Formula and Adult Medical Nutritionals." Journal of AOAC INTERNATIONAL 75, no. 5 (1992): 891–97. http://dx.doi.org/10.1093/jaoac/75.5.891.

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Abstract A liquid chromatographic method for the determination of pteroylglutamic acid (folic acid) in infant formula and liquid medical nutritional diets is described. Extraction of folic acid from the sample matrix is facilitated by a partial enzymatic digestion of the sample proteins. An aliquot of the sample preparation is injected onto a strong anion exchange column (SAX) for preliminary separation, using a pH 5.3 mobile phase of 0.02M sodium acetate and 0.02M sodium sulfate. Before the elution of the folic acid from the SAX column, the eluant is directed onto an octyl bonded-phase column (C8) by using automated switching valves. After the folic acid has been transferred to the C8 column, the SAX column is removed from the flow path. The folic acid is eluted from the Cs column by using an acetonitrile gradient. Detection is by absorption at 345 nm. The mean coefficient of variation is 3.6%, and the range of the recoveries of added folic acid is 95.5-100.2%. The method detection limit and method quantitation limit for infant formula are 10 and 28 µg/kg, respectively. This method is used routinely for the determination of folic acid in infant formula and liquid medical nutritional diets.

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Dissertations / Theses on the topic "Pteroylglutamic acid"

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Neuhouser, Marian L. Stone. "Absorption of pteroylglutamic acid and pteroylpolyglutamic acid in women with a history of neural tube defect affected pregnancies vs. controls /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6613.

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Poernama, Ferry. "Evidence of altered choline metabolism in the recessive white skin chicken and interaction of dietary folic acid (pteroylglutamic acid) and zinc on breeder hen and progeny performance." 1990. http://catalog.hathitrust.org/api/volumes/oclc/23044754.html.

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Books on the topic "Pteroylglutamic acid"

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Bradshaw, Spencer D. Folic Acid (Pteroylglutamic Acid) in Health, Deficiency & Therapy: Index of New Information With Authors, Subjects & References. Abbe Pub Assn of Washington Dc, 1996.

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Book chapters on the topic "Pteroylglutamic acid"

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Nelson, Marjorie M. "Teratogenig Effects of Pteroylglutamic Acid Deficiency in the Rat." In Ciba Foundation Symposium - Congenital Malformations. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470715277.ch7.

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Ainsworth, Sean. "F." In Neonatal Formulary, edited by Sean Ainsworth. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198840787.003.0019.

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This chapter presents information on neonatal drugs that begin with F, including use, pharmacology, adverse effects, fetal and infant implications of maternal treatment, treatment, and supply of Fentanyl, Fibrin sealants and cyanoacrylate tissue adhesives, Flecainide, Flucloxacillin (also cloxacillin and dicloxacillin), Fluconazole, Flucytosine, Fludrocortisone, Folic acid (pteroylglutamic acid), Formula milks for babies with intolerance/allergy, Formula milks for preterm babies, Fosfomycin, Fresh frozen plasma and cryoprecipitate, and Furosemide = Frusemide (former BAN)

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"AOAC Official Method 944.12Folic Acid (Pteroylglutamic Acid) in Vitamin Preparations." In Official Methods of Analysis of AOAC INTERNATIONAL, 22nd ed. Oxford University Press, 2023. http://dx.doi.org/10.1093/9780197610145.003.3775.

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"AOAC Official Method 992.05Total Folate (Pteroylglutamic Acid) in Infant Formula." In Official Methods of Analysis of AOAC INTERNATIONAL, 22nd ed. Oxford University Press, 2023. http://dx.doi.org/10.1093/9780197610145.003.4047.

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Singh, Jagdish. "Vitamin B9 in Dark Green Vegetables: Deficiency Disorders, Bio-Availability, and Fortification Issues." In B-Complex Vitamins - Sources, Intakes and Novel Applications. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.100318.

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Folic acid is a B complex water-soluble vitamin that is essential to humans, and its deficiency can cause problems including neural tube defects as well as heart-related diseases. An important feature of such vitamins is that they are generally not synthesized by mammalian cells and therefore must be supplied in sufficient amounts in the diet. Folate is a generic term for compounds, possessing vitamin activity similar to that of pteroylglutamic acid, and is the form of the vitamin, which is naturally present in foods. The main dietary sources of folic acid are dark green and leafy vegetables such as spinach, asparagus, romaine lettuce, broccoli, bok choy, turnip green, beet, dried or fresh beans, and peas. The amount of folate that is absorbed and utilized physiologically varies among different food sources and different chemical forms of the vitamin. About 85% of folic acid is estimated to be bioavailable; however, the bioavailability of food folate is estimated at about 50% of folic acid. Several national health authorities have introduced mandatory food fortification with synthetic folic acid, which is considered a convenient fortificant, being cost efficient in production, more stable than natural food folate, and superior in terms of bioavailability and bio-efficacy. Presently, many countries affected by diseases associated with a lack of folic acid have made it mandatory to supplement foods with the vitamin. Considering the need, several analytical procedures were standardized to determine the presence of folic acid in different food matrices. The reported methods are simple, selective, robust, and reproducible and can be used in routine analyses.

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