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Journal articles on the topic 'PTGER1'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Chandras, C., T. E. Harris, A. López Bernal, D. R. E. Abayasekara та A. E. Michael. "PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa–lutein cells". Journal of Endocrinology 194, № 3 (2007): 595–602. http://dx.doi.org/10.1677/joe-07-0128.

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In luteinizing granulosa cells, prostaglandin E2 (PGE2) can exert luteotrophic actions, apparently via the cAMP signalling pathway. In addition to stimulating progesterone synthesis, PGE2 can also stimulate oxidation of the physiological glucocorticoid, cortisol, to its inactive metabolite, cortisone, by the type 1 11β-hydroxysteroid dehydrogenase (11βHSD1) enzyme in human granulosa–lutein cells. Having previously shown these human ovarian cells to express functional G-protein coupled, E-series prostaglandin (PTGER)1, PTGER2 and PTGER4 receptors, the aim of this study was to delineate the role

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Miyoshi, Moe, Masayuki Sato, Kenji Saito, et al. "Maternal Protein Restriction Alters the Renal Ptger1 DNA Methylation State in SHRSP Offspring." Nutrients 10, no. 10 (2018): 1436. http://dx.doi.org/10.3390/nu10101436.

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We previously reported that maternal protein restriction (LP) during pregnancy increases salt sensitivity in offspring using the Stroke-Prone Spontaneously Hypertensive Rat (SHRSP). In the present study, we focus on DNA methylation profiles of prostaglandin E receptor 1 gene (ptger1), which is known to be associated with hypertension. We evaluated the ptger1 DNA methylation status via bisulfite sequencing, and analyzed the expression of ptger1-related genes. The results of these analyses showed that, compared to controls, the LP-S offspring exhibited both marked ptger1 hypermethylation, and si

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González, Luz María, Nicolás Roberto Robles, Sonia Mota-Zamorano, José Manuel Valdivielso, Juan López-Gómez, and Guillermo Gervasini. "Genetic Variants in PGE2 Receptors Modulate the Risk of Nephrosclerosis and Clinical Outcomes in These Patients." Journal of Personalized Medicine 11, no. 8 (2021): 772. http://dx.doi.org/10.3390/jpm11080772.

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Prostaglandin E2 (PGE2) is a major actor mediating renal injury. We aimed to determine genetic variability in the genes coding for its receptors (PTGER1-4) and study associations with nephrosclerosis risk and clinical outcomes. We identified 96 tag-SNPs capturing global variability in PTGER1-4 and screened 1209 nephrosclerosis patients and controls. The effect of these variants was evaluated by multivariate regression analyses. Two PTGER3 SNPs, rs11209730 and rs10399704, remained significant in a backward elimination regression model with other non-genetic variables (OR = 1.45 (1.07–1.95), p =

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Kowalewski, Mariusz Pawel, Hakki Bülent Beceriklisoy, Christiane Pfarrer, et al. "Canine placenta: a source of prepartal prostaglandins during normal and antiprogestin-induced parturition." REPRODUCTION 139, no. 3 (2010): 655–64. http://dx.doi.org/10.1530/rep-09-0140.

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Expression of cyclooxygenase 2 (COX2, now known as PTGS2), prostaglandin E2 synthase (PTGES, PGES), and prostaglandin F2α synthase (PGFS), of the respective receptors PTGFR (FP), PTGER2 (EP2), and PTGER4 (EP4) and of the progesterone receptor (PGR, PR) was assessed by real-time PCR, immunohistochemistry (IHC), or in situ hybridization (ISH) in utero/placental tissue samples collected from three to five bitches on days 8–12 (pre-implantation), 18–25 (post-implantation), and 35–40 (mid-gestation) of pregnancy and during the prepartal luteolysis. Additionally, ten mid-pregnant bitches were treate

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Jia, Huijuan, Moe Miyoshi, Xuguang Li, et al. "The Epigenetic Legacy of Maternal Protein Restriction: Renal Ptger1 DNA Methylation Changes in Hypertensive Rat Offspring." Nutrients 15, no. 18 (2023): 3957. http://dx.doi.org/10.3390/nu15183957.

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Nutrient imbalances during gestation are a risk factor for hypertension in offspring. Although the effects of prenatal nutritional deficiency on the development of hypertension and cardiovascular diseases in adulthood have been extensively documented, its underlying mechanisms remain poorly understood. In this study, we aimed to elucidate the precise role and functional significance of epigenetic modifications in the pathogenesis of hypertension. To this end, we integrated methylome and transcriptome data to identify potential salt-sensitive hypertension genes using the kidneys of stroke-prone

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Zschockelt, Lina, Olga Amelkina, Marta J. Siemieniuch, et al. "Synthesis and reception of prostaglandins in corpora lutea of domestic cat and lynx." Reproduction 152, no. 2 (2016): 111–26. http://dx.doi.org/10.1530/rep-16-0180.

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Felids show different reproductive strategies related to the luteal phase. Domestic cats exhibit a seasonal polyoestrus and ovulation is followed by formation ofcorpora lutea(CL). Pregnant and non-pregnant cycles are reflected by diverging plasma progesterone (P4) profiles. Eurasian and Iberian lynxes show a seasonal monooestrus, in which physiologically persistent CL (perCL) support constantly elevated plasma P4 levels. Prostaglandins (PGs) represent key regulators of reproduction, and we aimed to characterise PG synthesis in feline CL to identify their contribution to the luteal lifespan. We

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7

Thibodeau, Jean-François, Rania Nasrallah, Anthony Carter, et al. "PTGER1 Deletion Attenuates Renal Injury in Diabetic Mouse Models." American Journal of Pathology 183, no. 6 (2013): 1789–802. http://dx.doi.org/10.1016/j.ajpath.2013.08.022.

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8

Nuttinck, Fabienne, Brigitte Marquant-Le Guienne, Laetitia Clément, Pierrette Reinaud, Gilles Charpigny, and Bénédicte Grimard. "Expression of genes involved in prostaglandin E2 and progesterone production in bovine cumulus–oocyte complexes during in vitro maturation and fertilization." REPRODUCTION 135, no. 5 (2008): 593–603. http://dx.doi.org/10.1530/rep-07-0453.

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Prostaglandin E2(PGE2) and progesterone appear to be critical mediators of cumulus expansion and the resumption of oocyte meiosis. The aim of this study was to identify the types of prostaglandin E synthase (PTGES) expressed in the bovine cumulus–oocyte complex (COC), to characterize their temporal expression during the periconceptional interval using anin vitromodel of maturation (IVM) and fertilization (IVF), and to compare their expression with the level of steroidogenic gene expression. Real-time RT-PCR analysis revealed that enzymes related to the PGE2biosynthesis pathway were mainly expr

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Waclawik, Agnieszka, Piotr Kaczynski, and Henry N. Jabbour. "Autocrine and Paracrine Mechanisms of Prostaglandin E2 Action on Trophoblast/Conceptus Cells through the Prostaglandin E2 Receptor (PTGER2) during Implantation." Endocrinology 154, no. 10 (2013): 3864–76. http://dx.doi.org/10.1210/en.2012-2271.

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The conceptus and endometrium secrete large amounts of prostaglandin E2 (PGE2) into the porcine uterine lumen during the periimplantation period. We hypothesized that PGE2 acts on conceptus/trophoblast cells through auto- and paracrine mechanisms. Real-time RT-PCR analysis revealed that PGE2 receptor (PTGER)2 mRNA was 14-fold greater in conceptuses/trophoblasts on days 14–25 (implantation and early placentation period) vs preimplantation day 10–13 conceptuses (P &lt; .05). Similarly, expression of PTGER2 protein increased during implantation. Conceptus expression of PTGER4 mRNA and protein

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Jamshed, Laiba, Genevieve A. Perono, Shanza Jamshed, Kim Ann Cheung, Philippe J. Thomas, and Alison Holloway. "The Effects of Naphthenic Acids on Tryptophan Metabolism and Peripheral Serotonin Signalling." Journal of the Endocrine Society 5, Supplement_1 (2021): A493. http://dx.doi.org/10.1210/jendso/bvab048.1008.

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Abstract Introduction: Serotonin produced in the periphery has been shown to affect glucose and lipid homeostasis. The availability of the amino acid tryptophan, the precursor of serotonin, affects serotonin availability. In addition, the metabolism of tryptophan via the kynurenine pathway produces physiologically active metabolites which have been shown to be altered under conditions of increased adiposity and dysglycemia. There is now evidence demonstrating some environmental xenobiotics, known to affect glucose and lipid homeostasis, can also alter serotonin production and key components of

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Zhao, Xin-mei, Yuan-Bin Li, Peng Sun, Ya-di Pu, Meng-jie shan, and Yuan-meng Zhang. "Bioinformatics analysis of key biomarkers for retinoblastoma." Journal of International Medical Research 49, no. 6 (2021): 030006052110222. http://dx.doi.org/10.1177/03000605211022210.

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Objective To identify key genes involved in occurrence and development of retinoblastoma. Methods The microarray dataset, GSE5222, was downloaded from the gene expression omnibus (GEO) database. Differentially expressed genes (DEGs) between unilateral and bilateral retinoblastoma were identified and functional enrichment analysis performed. The protein–protein interaction (PPI) network was constructed and analysed by STRING and Cytoscape. Results DEGs were mainly associated with activation of cysteine-type endopeptidase activity involved in apoptotic process and small molecule catabolic proces

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Plaza-Serón, María del Carmen, Pedro Ayuso, Natalia Pérez-Sánchez, et al. "Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema." Pharmacogenetics and Genomics 26, no. 6 (2016): 280–87. http://dx.doi.org/10.1097/fpc.0000000000000216.

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Seron, Maria Del Carmen Plaza, Pedro Ayuso Parejo, Natalia Blanca-López, et al. "Copy Number Variations In ALOX5 and PTGER1 Genes Are Associated With Susceptibility To AERD and Mnsaid-UA." Journal of Allergy and Clinical Immunology 133, no. 2 (2014): AB264. http://dx.doi.org/10.1016/j.jaci.2013.12.936.

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Waclawik, Agnieszka, Agnieszka Blitek та Adam J. Ziecik. "Oxytocin and tumor necrosis factor α stimulate expression of prostaglandin E2 synthase and secretion of prostaglandin E2 by luminal epithelial cells of the porcine endometrium during early pregnancy". REPRODUCTION 140, № 4 (2010): 613–22. http://dx.doi.org/10.1530/rep-10-0092.

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Oxytocin (OXT) and tumor necrosis factor α (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F2α(PGF2α). Nevertheless, OXT concentration in porcine uterine lumen increases markedly on days 11–12 of pregnancy, and TNF is expressed in endometrium during pregnancy. The objective of the study was to determine the effect of OXT and TNF on expression of the enzymes involved in PG synthesis: PG-endoperoxide synthase 2 (PTGS2), PGE2synthase (mPGES-1) and PGF synthase, and PGE2receptor (PTGER2), as well as on PG secretion by endomet

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Karaky, Mohamad, Gabrielle Boucher, Saraï Mola, et al. "Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases." PLOS Genetics 18, no. 9 (2022): e1010189. http://dx.doi.org/10.1371/journal.pgen.1010189.

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Background Genome wide association studies (GWAS) have identified and validated more than 200 genomic loci associated with the inflammatory bowel disease (IBD), although for most the causal gene remains unknown. Given the importance of myeloid cells in IBD pathogenesis, the current study aimed to uncover the role of genes within IBD genetic loci that are endogenously expressed in this cell lineage. Methods The open reading frames (ORF) of 42 genes from IBD-associated loci were expressed via lentiviral transfer in the THP-1 model of human monocytes and the impact of each of these on the cell’s

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Nie, Yanfang, Haifeng Yu, Xiaoqing Wan, et al. "Identification of autophagy-related biomarker and analysis of immune infiltrates in diabetic nephropathy: PTGER1 protein macromolecular structure and function." International Journal of Biological Macromolecules 311 (June 2025): 144063. https://doi.org/10.1016/j.ijbiomac.2025.144063.

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Przygrodzka, E., M. M. Kaczmarek, P. Kaczynski, and A. J. Ziecik. "Steroid hormones, prostanoids, and angiogenic systems during rescue of the corpus luteum in pigs." REPRODUCTION 151, no. 2 (2016): 135–47. http://dx.doi.org/10.1530/rep-15-0332.

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In order to characterize the transition of the corpora lutea (CL) from acquisition of luteolytic sensitivity to rescue of luteal function: i) the expression of 38 factors associated with steroids, prostanoids, and angiogenic systems and ii) concentrations of the main hormones responsible for maintenance of CL function in cyclic and pregnant pigs were examined. Additionally, the effect of prostaglandin (PG) E2 and F2α on luteal function during the estrous cycle and pregnancy was evaluated in vitro. Significantly up-regulated gene expression was revealed in CL collected on day 14 of the estrous

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Gillio-Meina, Carolina, Sen Han Phang, James P. Mather, Brian S. Knight, and Thomas G. Kennedy. "Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization." REPRODUCTION 137, no. 3 (2009): 537–52. http://dx.doi.org/10.1530/rep-08-0294.

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To determine if changes in endometrial expression of the enzymes and receptors involved in prostaglandin (PG) synthesis and action might provide insights into the PGs involved in the initiation of decidualization, ovariectomized steroid-treated rats at the equivalent of day 5 of pseudopregnancy were given a deciduogenic stimulus and killed at various times up to 32 h thereafter. The expression of PG-endoperoxide synthases (PTGS1 and PTGS2), microsomal PGE synthases (PTGES and PTGES2), cytosolic PGE synthase (PTGES3), prostacyclin synthase (PTGIS), prostacyclin receptor, peroxisome proliferator

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Mangelsen, Eva, Michael Rothe, Angela Schulz, et al. "Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E2 Activation in Human Podocytes." Cells 9, no. 5 (2020): 1256. http://dx.doi.org/10.3390/cells9051256.

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Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman’s space. Elevated Prostaglandin E2 (PGE2) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated with podocyte injury by FFSS. We aimed to elucidate a PGE2 autocrine/paracrine pathway in human podocytes (hPC). We developed a modified liquid chromatography tandem mass spectrometry (LC/ESI-MS/MS) protocol to quantify cellular PGE2, 15-keto-PGE2, and 13,14-dihydro-15-keto-PGE2 levels. hPC were treated

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Murthy, Divya, and Kuldeep S. Attri. "PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma." International Journal of Molecular Sciences 24, no. 8 (2023): 7304. http://dx.doi.org/10.3390/ijms24087304.

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Metabolic reprogramming is an established hallmark of multiple cancers, including pancreatic cancer. Dysregulated metabolism is utilized by cancer cells for tumor progression, metastasis, immune microenvironment remodeling, and therapeutic resistance. Prostaglandin metabolites have been shown to be critical for inflammation and tumorigenesis. While the functional role of prostaglandin E2 metabolite has been extensively studied, there is a limited understanding of the PTGES enzyme in pancreatic cancer. Here, we investigated the relationship between expression of prostaglandin E synthase (PTGES)

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Wajda, Anna, Diana Bogucka, Barbara Stypińska та ін. "Expression of Prostaglandin Genes and β-Catenin in Whole Blood as Potential Markers of Muscle Degeneration". International Journal of Molecular Sciences 24, № 16 (2023): 12885. http://dx.doi.org/10.3390/ijms241612885.

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Prostaglandin signaling pathways are closely related to inflammation, but also muscle regeneration and processes associated with frailty and sarcopenia, whereas β-catenin (CTNNB1 gene) as a part of Wnt signaling is also involved in the differentiation of muscle cells and fibrosis. The present study analyzed the association between selected prostaglandin pathway genes and clinical parameters in patients with sarcopenia and frailty syndrome. The present study was conducted on patients with sarcopenia, frailty syndrome, and control older patients (N = 25). Additionally, two healthy controls at th

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Nelis, H. M., K. Goossens, B. Leemans, L. Peelman, and A. Van Soom. "220 STEROID-REGULATED mRNA EXPRESSION IN OVIDUCT EPITHELIAL CELLS IN THE MARE." Reproduction, Fertility and Development 25, no. 1 (2013): 258. http://dx.doi.org/10.1071/rdv25n1ab220.

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It is well known that oviducal physiology undergoes cyclical changes under the influence of steroid hormones associated with the establishment of an optimal microenvironment for fertilization and early embryonic development. Genes associated with the preovulatory phase are likely to be involved in modulation of gamete function and sperm storage, whereas those in the post-ovulatory phase are involved in embryonic development. So far, in the horse, no genes that change activity during the oestrous cycle, which may be important in fertilization, gamete and embryo passage, and early embryonic deve

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Hartney, John M., Kenneth G. Coggins, Stephen L. Tilley, et al. "Prostaglandin E2 protects lower airways against bronchoconstriction." American Journal of Physiology-Lung Cellular and Molecular Physiology 290, no. 1 (2006): L105—L113. http://dx.doi.org/10.1152/ajplung.00221.2005.

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Prostaglandin E2 (PGE2), similar to β-adrenergic receptor agonists, can protect airways from bronchoconstriction and resulting increase in airway resistance induced by a number of agents, including cholinergic receptor agonists and antigen. We examined the impact of sustained alterations in PGE2 pathways on changes in airway resistance. Genetic methods were utilized to alter PGE2 metabolism and signal transduction in the murine lung. PGE2 levels were elevated by generating mice lacking 15-hydroxyprostaglandin ( Hpgd−/−), the major catabolic enzyme of PGE2, and by generating a transgenic line i

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Misawa, Kiyoshi, Atsushi Imai, Takeharu Kanazawa, et al. "G Protein-Coupled Receptor Genes, PTGDR1, PTGDR2, and PTGIR, Are Candidate Epigenetic Biomarkers and Predictors for Treated Patients with HPV-Associated Oropharyngeal Cancer." Microorganisms 8, no. 10 (2020): 1504. http://dx.doi.org/10.3390/microorganisms8101504.

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Differences in the biology of human papillomavirus (HPV)-associated oropharyngeal cancers (OPCs) and HPV-negative OPCs may have implications in patient management. Early detection is imperative to reduce HPV-associated OPC mortality. Circulating tumor DNA (ctDNA) can potentially serve as a biomarker for monitoring clinically relevant cancer-related genetic and epigenetic modifications. We analyzed the methylation status of 24 G protein-coupled receptor (GPCR) genes in verification (85 OPC primary samples) and validation (8 OPC ctDNA samples) studies using quantitative methylation-specific poly

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Kim, Soon Ok, Nune Markosyan, Gerald J. Pepe та Diane M. Duffy. "Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells". REPRODUCTION 149, № 5 (2015): 453–64. http://dx.doi.org/10.1530/rep-14-0412.

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Prostaglandin F2α (PGF2α) has been proposed as a functional luteolysin in primates. However, administration of PGF2α or prostaglandin synthesis inhibitors in vivo both initiate luteolysis. These contradictory findings may reflect changes in PGF2α receptors (PTGFRs) or responsiveness to PGF2α at a critical point during the life span of the corpus luteum. The current study addressed this question using ovarian cells and tissues from female cynomolgus monkeys and luteinizing granulosa cells from healthy women undergoing follicle aspiration. PTGFRs were present in the cytoplasm of monkey granulosa

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Hildebrand, Carolin, Julia Hollenbach, Bettina Seeger та Christiane Pfarrer. "β-Hydroxybutyrate Effects on Bovine Caruncular Epithelial Cells: A Model for Investigating the Peri-Implantation Period Disruption in Ketotic Dairy Cows". Animals 13, № 18 (2023): 2950. http://dx.doi.org/10.3390/ani13182950.

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Ketosis is a metabolic disorder arising from a negative energy balance (NEB). It is characterized by high β-Hydroxybutyrate (BHBA) blood levels and associated with reduced fertility in dairy cows. To investigate the impact of BHBA on bovine caruncular epithelial cells (BCEC) in vitro, these cells were stimulated with different concentrations of BHBA. Cell metabolism and motility were examined using an MTT assay and Live-cell imaging. RT-qPCR was used to examine mRNA expressions of TNF, IL6, RELA, prostaglandin E2 synthase (PTGES2) and receptor (PTGER2) as well as integrin subunits ITGAV, ITGA6

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Kautz, E., A. Gram, S. Aslan, et al. "Expression of genes involved in the embryo–maternal interaction in the early-pregnant canine uterus." REPRODUCTION 147, no. 5 (2014): 703–17. http://dx.doi.org/10.1530/rep-13-0648.

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Although there is no acute luteolytic mechanism in the absence of pregnancy in the bitch, a precise and well-timed embryo–maternal interaction seems to be required for the initiation and maintenance of gestation. As only limited information is available about these processes in dogs, in this study, the uterine expression of possible decidualization markers was investigated during the pre-implantation stage (days 10–12) of pregnancy and in the corresponding nonpregnant controls. In addition, the expression of selected genes associated with blastocyst development and/or implantation was investig

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Walusimbi, S. S., L. M. Wetzel, D. H. Townson, and J. L. Pate. "Isolation of luteal endothelial cells and functional interactions with T lymphocytes." Reproduction 153, no. 5 (2017): 519–33. http://dx.doi.org/10.1530/rep-16-0578.

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The objectives of this study were to optimize the isolation of luteal endothelial cells (LEC) and examine their functional interactions with autologous T lymphocytes. Analysis by flow cytometry showed that the purity of LEC isolated by filtration was nearly 90% as indicated byBandeiraea simplicifolia(BS)-1 lectin binding. LEC expressed mRNA for progesterone receptor (PGR), prostaglandin receptors (PTGFR, PTGER2 and 4, and PTGIR), tumor necrosis factor receptors (TNFRSF1A&B) and interleukin (IL) 1B receptors (IL1R1&2). LEC were pretreated with either vehicle, progesterone (P4; 0–20 µM),

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Markosyan, Nune, Ilkyu Kim, Charu Arora, et al. "Abstract 4985: Pivotal roles for cancer cell-intrinsic mPGES-1 and autocrine EP4 signaling in suppressing anti-tumor immunity." Cancer Research 84, no. 6_Supplement (2024): 4985. http://dx.doi.org/10.1158/1538-7445.am2024-4985.

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Abstract Tumor cell-derived prostaglandin E2 (PGE2) is a tumor cell-intrinsic factor that supports immunosuppression in the tumor microenvironment (TME). Using a genetically engineered mouse model of pancreatic ductal adenocarcinoma, we demonstrate that deleting the terminal PGE2 synthesis enzyme or disrupting autocrine PGE2 signaling through cognate EP4 receptors on tumor cells reverses the T cell-low, myeloid cell-rich TME to activate T cell immunity and suppress tumor growth. Knockout (KO) of Ptges (the gene encoding PGE2 synthesis enzyme mPGES-1) or the EP4 receptor gene (Ptger4) in KPCY (

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Yang, Ling, Xu Han, Leying Zhang, Ning Li, Zimo Zhao, and Jiachen Bai. "Changes in expression of prostaglandin synthase in ovine liver during early pregnancy." Canadian Journal of Animal Science 100, no. 3 (2020): 432–39. http://dx.doi.org/10.1139/cjas-2019-0171.

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Liver can function as part of the innate and adaptive immune systems. We hypothesize that prostaglandins participate in the regulation of hepatic immune function during early pregnancy in sheep. The objective of this study was to elucidate expression of prostaglandin synthase in ovine liver during early pregnancy. Ovine livers were sampled on day 16 of the estrous cycle, and days 13, 16, and 25 of pregnancy, and the expression of prostaglandin synthases, including prostaglandin-endoperoxide synthase 1 (PTGS1), PTGS2, prostaglandin E synthase (PTGES), and aldo-keto reductase family 1, member B1

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Markosyan, Nune, Il-Kyu Kim, Charu Arora, et al. "Abstract B033: Tumor cell-intrinsic mPGES-1-PGE2-EP4 signaling is a major immunosuppressive pathway in pancreatic cancer." Cancer Research 84, no. 2_Supplement (2024): B033. http://dx.doi.org/10.1158/1538-7445.panca2023-b033.

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Abstract Pancreatic adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US partly because of its resistance to conventional chemotherapies. Immunotherapies that improve survival in many cancers, almost universally fail in PDA. The resistance to immune checkpoint blockade is at least partially explained by the lack of T cells in the tumor microenvironment (TME) in PDA. As demonstrated previously, tumor cell-derived prostaglandin E2 (PGE2) is one of the tumor intrinsic factors that creates/supports immunosuppressive TME in PDA. The current study investigates how depleti

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Williams, Joseph H., and Paulo E. Oliveira. "For things to stay the same, things must change: polyploidy and pollen tube growth rates." Annals of Botany 125, no. 6 (2020): 925–35. http://dx.doi.org/10.1093/aob/mcaa007.

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Abstract Background and Aims Pollen tube growth rate (PTGR) is an important single-cell performance trait that may evolve rapidly under haploid selection. Angiosperms have experienced repeated cycles of polyploidy (whole genome duplication), and polyploidy has cell-level phenotypic consequences arising from increased bulk DNA amount and numbers of genes and their interactions. We sought to understand potential effects of polyploidy on several underlying determinants of PTGR – pollen tube dimensions and construction rates – by comparing diploid–polyploid near-relatives in Betula (Betulaceae) an

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Yin, Yongmei, Ningjun Duan, Yijia Hua, and Shuang Hu. "Abstract 3698: Epigenetic modification induced reprogramming of PUFAs-associated metabolism during trastuzumab resistance formation of HER2-positive breast cancer." Cancer Research 83, no. 7_Supplement (2023): 3698. http://dx.doi.org/10.1158/1538-7445.am2023-3698.

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Abstract Background: Secondary trastuzumab resistance seriously affects the treatment of HER2-positive breast cancer. Although studies have demonstrated several potential reasons that cause trastuzumab resistance, we still have poor knowledge about the changes in cell itself as well as its interaction with tumor microenvironment (TME) components during resistance formation. Here we suggested that altered histone modification reprograms polyunsaturated fatty acids (PUFAs) metabolism, which reduces cellular PUFAs and stimulates prostaglandin E2 (PGE2) production. Excessive PGE2 may further affec

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Vianello, Elena, Elena Dozio, Francesco Bandera, et al. "Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and Its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects." International Journal of Molecular Sciences 21, no. 2 (2020): 520. http://dx.doi.org/10.3390/ijms21020520.

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There is recent evidence that the dysfunctional responses of a peculiar visceral fat deposit known as epicardial adipose tissue (EAT) can directly promote cardiac enlargement in the case of obesity. Here, we observed a newer molecular pattern associated with LV dysfunction mediated by prostaglandin E2 (PGE2) deregulation in EAT in a cardiovascular disease (CVD) population. A series of 33 overweight CVD males were enrolled and their EAT thickness, LV mass, and volumes were measured by echocardiography. Blood, plasma, EAT, and SAT biopsies were collected for molecular and proteomic assays. Our d

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Diel de Amorim, Mariana, Claudia Klein, Robert Foster, Lynn Dong, Maria Fernanda Lopez-Rodriguez, and Claire Card. "Expression of Oxytocin/Neurophysin I and Oxytocinase in the Equine Conceptus from Day 8 to Day 21 Post-Ovulation." Animals 12, no. 7 (2022): 799. http://dx.doi.org/10.3390/ani12070799.

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Leucyl and cystinyl aminopeptidase (LNPEP/oxytocinase) is an enzyme that metabolizes oxytocin in serum and tissues. The presence of oxytocin/neurophysin I (OXT), oxytocin and LNPEP and their relationship to other genes is unknown in the equine conceptus. Our objective was to characterize gene expression of LNPEP and OXT on D8, 10, 12, 14, 15, 16 and 21 conceptuses in relationship to other genes. Immunohistochemistry, western blot and liquid chromatography with tandem mass spectrometry (LC-MS/MS) were used for identification of oxytocin and LNPEP in D15, 16 and 18 conceptuses. LNPEP was increas

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Wang, Yingzi, Andrei V. Krivtsov, Amit U. Sinha та ін. "β-Catenin Determines Developmental Stage Specific Transformation by Hox Genes." Blood 114, № 22 (2009): 385. http://dx.doi.org/10.1182/blood.v114.22.385.385.

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Abstract Abstract 385 Leukemia stem cells (LSC) possess extensive proliferative and self-renewal potential similar to normal hematopoietic stem cells (HSC). Therefore understanding the similarities and differences between HSC and LSC is critical if LSC specific therapies are to be developed. Hox genes represent a group of genes that can influence both normal HSC and LSC self-renewal, and are critical targets of leukemogenic MLL fusion proteins. Previous reports have described the ability of Hoxa9 and Meis1a (HoxA9/M) to induce leukemia when expressed in mouse bone marrow (BM). However, whether

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Gordeuk, Victor R., Xu Zhang, Wei Zhang, et al. "Novel Putative Polymorphism in SERPINC1 Encoding Antithrombin III Is Implicated in Elevated Estimated Systolic Pulmonary Pressure in Patients with Chuvash Polycythemia." Blood 120, no. 21 (2012): 2869. http://dx.doi.org/10.1182/blood.v120.21.2869.2869.

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Abstract Abstract 2869 Chuvash polycythemia (CP) is characterized by homozygosity for the R200W mutation in the von Hippel Lindau gene (VHL). This rare genetic disorder causes elevated levels of hypoxia inducible factor (HIF)-1 and HIF-2 that trigger constitutive hypoxia responses at normoxia. Hypoxia is a recognized cause of pulmonary hypertension. We recently reported that systolic pulmonary artery pressure (SPAP) estimated by echocardiography-determined tricuspid regurgitation velocity (TRV) was elevated in 120 CP patients compared to 31 Chuvash controls (P = 0.005), and that increasing age

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Lee, Jia Ming, Jemma R. Mayall, Anne Chevalier, et al. "Chlamydia muridarum infection differentially alters smooth muscle function in mouse uterine horn and cervix." American Journal of Physiology-Endocrinology and Metabolism 318, no. 6 (2020): E981—E994. http://dx.doi.org/10.1152/ajpendo.00513.2019.

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Chlamydia trachomatis infection is a primary cause of reproductive tract diseases including infertility. Previous studies showed that this infection alters physiological activities in mouse oviducts. Whether this occurs in the uterus and cervix has never been investigated. This study characterized the physiological activities of the uterine horn and the cervix in a Chlamydia muridarum ( Cmu)-infected mouse model at three infection time points of 7, 14, and 21 days postinfection (dpi). Cmu infection significantly decreased contractile force of spontaneous contraction in the cervix (7 and 14 dpi

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Robertson, Sarah A., Inge Christiaens, Camilla L. Dorian, et al. "Interleukin-6 Is an Essential Determinant of On-Time Parturition in the Mouse." Endocrinology 151, no. 8 (2010): 3996–4006. http://dx.doi.org/10.1210/en.2010-0063.

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IL-6 abundance in amniotic fluid and uterine tissues increases in late gestation or with infection-associated preterm labor. A role in regulation of labor onset is suggested by observations that IL-6 increases expression of genes controlling prostaglandin synthesis and signaling in isolated uterine cells, but whether IL-6 is essential for normal parturition is unknown. To evaluate the physiological role of IL-6 in parturition in mice, we investigated the effect of Il6 null mutation on the timing of parturition and expression of genes associated with uterine activation. Il6 null mutant mice del

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Chen, Dongjiang, Son Le, Tarun Hutchinson, and David Tran. "DDRE-13. PROSTAGLANDIN E RECEPTOR 3 (PTGER3) REGULATES RESISTANCE TO TUMOR TREATING FIELDS (TTFields) IN GLIOBLASTOMA CELLS." Neuro-Oncology 23, Supplement_6 (2021): vi77. http://dx.doi.org/10.1093/neuonc/noab196.297.

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Abstract INTRODUCTION TTFields, a novel approved therapy for GBM, employ alternating intermediate-frequency electric fields to disrupt mitotic macromolecules leading to chromosome mis-segregation and apoptosis. The addition of TTFields significantly improves survival. However, most patients eventually develop resistance to TTFields through an unknown mechanism. METHODS Multiple human GBM cell lines were treated with TTFields continuously using Inovitro, an in vitro TTFields system, until cells with relative resistance to killing by TTFields emerged. Temporal gene expression profiles were analy

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Liu, Kuankuan, Li Shu, Ann Yehong Huang, Yanan Chang, Zhongqiang Chen, and Chi Zhang. "PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum." PLOS ONE 18, no. 11 (2023): e0292821. http://dx.doi.org/10.1371/journal.pone.0292821.

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Thoracic ossification of the ligamentum flavum (TOLF) is a heterotopic ossification of spinal ligaments, leading to serious myelopathy. TOLF underlying mechanisms are not well understood. Our iTRAQ analysis have identified ten inflammatory factors related to TOLF, including l. We found that PTGR1 expressions increased in TOLF by RT-PCR and western blot in this study. Both cell proliferation and differentiation are important for the process of bone formation. In our previous study, we demonstrated that TOLF primary cells grew faster than control cells. It was reported that knockdown of PTGR1 in

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Chinchilla-Tábora, Luis Miguel, Juan Carlos Montero, Luis Antonio Corchete, et al. "Differentially Expressed Genes Involved in Primary Resistance to Immunotherapy in Patients with Advanced-Stage Pulmonary Cancer." International Journal of Molecular Sciences 25, no. 4 (2024): 2048. http://dx.doi.org/10.3390/ijms25042048.

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In the last few years, nivolumab has become the standard of care for advanced-stage lung cancer patients. Unfortunately, up to 60% of patients do not respond to this treatment. In our study, we identified variations in gene expression related to primary resistance to immunotherapy. Bronchoscopy biopsies were obtained from advanced non-small cell lung cancer (NSCLC) patients previously characterized as responders or non-responders after nivolumab treatment. Ten tumor biopsies (from three responders and seven non-responders) were analyzed by the differential expression of 760 genes using the Nan

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Bae, In Ah, Jae Won Ha, and Yong Chool Boo. "Chlorogenic Acid, a Component of Oenanthe javanica (Blume) DC., Attenuates Oxidative Damage and Prostaglandin E2 Production Due to Particulate Matter 10 in HaCaT Keratinocytes." Cosmetics 10, no. 2 (2023): 60. http://dx.doi.org/10.3390/cosmetics10020060.

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Oenanthe javanica (OJ) is a perennial herb that grows wildly or is cultivated in Asia, and it is used as food or in traditional medicine. The antioxidant and anti-inflammatory effects of OJ-derived materials have been extensively explored previously, but their effects on the cytotoxicity of air pollution are currently unknown. Therefore, the present study aimed to evaluate the effect of the hot water extract of OJ on atmospheric particulate matter 10 (PM10)-induced cytotoxicity and oxidative damage in human HaCaT keratinocytes, and to identify its active ingredient and mechanism of action. Whe

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Murn, Jernej, Olivier Alibert, Ning Wu, Simon Tendil, and Xavier Gidrol. "Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4." Journal of Experimental Medicine 205, no. 13 (2008): 3091–103. http://dx.doi.org/10.1084/jem.20081163.

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B cell receptor (BCR) signaling contributes to the pathogenesis of B cell malignancies, and most B cell lymphomas depend on BCR signals for survival. Identification of genes that restrain BCR-mediated proliferation is therefore an important goal toward improving the therapy of B cell lymphoma. Here, we identify Ptger4 as a negative feedback regulator of proliferation in response to BCR signals and show that its encoded EP4 receptor is a principal molecule conveying the growth-suppressive effect of prostaglandin E2 (PGE2). Stable knockdown of Ptger4 in B cell lymphoma markedly accelerated tumor

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Kamyshna, Iryna, and Aleksandr Kamyshnyi. "Transcriptional Activity of Neurotrophins Genes and Their Receptors in the Peripheral Blood in Patients with Thyroid Diseases in Bukovinian Population of Ukraine." Open Access Macedonian Journal of Medical Sciences 9, A (2021): 208–16. http://dx.doi.org/10.3889/oamjms.2021.6037.

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Objective. Thyroid hormone has an especially strong impact on central nervous system development, and thyroid hormone deﬁciency has been shown to result in severe mental retardation. It is crucial to identify compensatory mechanisms that can be involved in improving cognitive function and the quality of life of patients with hypothyroidism. Methods: We used the pathway-specific PCR array (Neurotrophins and Receptors RT2 Profiler PCR Array, QIAGEN, Germany) to identify and validate neurotrophins genes and their receptor expression in patients with thyroid pathology and control group.&#x0D

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Huang, Xianping, Weihe Zhou, Yuefeng Zhang, and Yong Liu. "High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex." BioMed Research International 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/5230642.

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Lung cancer has been the most common cancer and the main cause of cancer-related deaths worldwide for several decades. PTGR1 (prostaglandin reductase 1), as a bifunctional enzyme, has been involved in the occurrence and progression of cancer. However, its impact on human lung cancer is rarely reported. In this study, we found that PTGR1 was overexpressed in lung cancer based on the analyses of Oncomine. Moreover, lentivirus-mediated shRNA knockdown of PTGR1 reduced cell viability in human lung carcinoma cells 95D and A549 by MTT and colony formation assay. PTGR1 depletion led to G2/M phase cel

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Yamazaki, Atsushi, Kazuya Edamura, Yuma Tomo, Mamiko Seki, and Kazushi Asano. "Variations in gene expression levels with severity of synovitis in dogs with naturally occurring stifle osteoarthritis." PLOS ONE 16, no. 1 (2021): e0246188. http://dx.doi.org/10.1371/journal.pone.0246188.

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Osteoarthritis (OA) is one of the major causes of chronic pain in dogs. However, the pathogenesis of OA has not been fully understood in dogs. The objective of this study was to comprehensively investigate the mRNA expression levels of proinflammatory cytokines, inflammatory mediators, nerve growth factor and its receptor, and matrix metalloproteinases in the synovium of dogs with spontaneous OA as well as to elucidate their relationships with the severity of synovitis. Dogs that were diagnosed with stifle OA on the basis of radiographic findings were included, and the degree of synovitis was

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Phuong, Ngoc Anh, Van Luong Dinh, Van Ba Nguyen, and Huu Tho Ho. "EVALUATION OF PTGER4 GENE METHYLATION IN PLASMA FOR LUNG CANCER DETECTION." VietNam Military Medical Unisversity 50, no. 4 (2025): 14–21. https://doi.org/10.56535/jmpm.v50i4.1232.

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Objectives: To evaluate the diagnostic value of PTGER4 (Prostaglandin E Receptor 4) gene methylation in plasma for lung cancer detection compared to healthy controls. Methods: A cross-sectional, case-control study was conducted on 149 non-small cell lung cancer (NSCLC) patients and 100 healthy individuals. Peripheral blood samples were collected for PTGER4 methylation analysis using real-time methylation-specific PCR (MSP). Data were analyzed using SPSS 26.0, including group comparisons, receiver operating characteristic (ROC) analysis, and logistic regression. Results: The PTGER4 methylation

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Kobayashi, Yoshihiko, Kaori Wakamiya, Misa Kohka, Yuki Yamamoto, and Kiyoshi Okuda. "Summer heat stress affects prostaglandin synthesis in the bovine oviduct." REPRODUCTION 146, no. 2 (2013): 103–10. http://dx.doi.org/10.1530/rep-12-0479.

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Summer heat stress (HS) negatively affects reproductive functions, including prostaglandin (PG) F2α secretion in the endometrium, and decreases fertility in cattle. In the present study, we examined the effects of elevated temperatures on PG synthesis in oviductal epithelial cells. The epithelial cells obtained from the ampulla and isthmus of the oviduct were incubated at various temperatures (38.5, 39.5, 40.0, and 40.5 °C) for 24 h. In the ampulla, PGE2 concentration was higher at 40.5 °C than at 38.5 °C, while PGF2α production was not affected by the temperatures in this range. The expressio

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Wu, Victoria H., Alexander Wenzel, Bryan Yung, Zhiyong Wang, Jill P. Mesirov та J. Silvio Gutkind. "Illuminating the onco-GPCRome: targeting the prostaglandin receptor-Gαs signaling axis as a novel immune checkpoint in cancer". Journal of Immunology 204, № 1_Supplement (2020): 165.37. http://dx.doi.org/10.4049/jimmunol.204.supp.165.37.

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Abstract Recent advances in checkpoint blockade immunotherapy (CBI) have revolutionized cancer treatment, but the limited response rates in most cancers suggest that new approaches and targets are clearly needed to fully elucidate the underlying biology of dysfunctional CD8 T cells and achieve durable responses. G-protein coupled receptors (GPCRs) are the most intensively studied drug targets as they play key roles in many physiological processes, and they have remained longstanding favorable pharmacological targets. Using novel computational approaches integrating multiple single cell RNAseq

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