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Journal articles on the topic 'Ptk2b'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Pallarès, Victor, Montserrat Hoyos, M. Chillón, et al. "Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia." Cancers 10, no. 11 (2018): 436. http://dx.doi.org/10.3390/cancers10110436.

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In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to implement risk-adapted strategies. The non-receptor tyrosine kinases are proteins involved in regulation of cell growth, adhesion, migration and apoptosis. They associate with metastatic dissemination in solid tumors and poor prognosis. However, their role in haematological malignancies has been scarcely studied. We hypothesized that PTK2/FAK, PTK2B/PYK2, LYN or SRC could be new prognostic markers in IR-AML. We assessed PTK2, PTK2B, LYN an

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Porter, Tyrel, Miguel Mayol del Valle, and Lilia Kucheryavykh. "Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population." International Journal of Molecular Sciences 25, no. 9 (2024): 4947. http://dx.doi.org/10.3390/ijms25094947.

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Glioblastoma (GBM), an aggressive form of brain cancer, has a higher incidence in non-Hispanics when compared to the US Hispanic population. Using data from RT-PCR analysis of 21 GBM tissue from Hispanic patients in Puerto Rico, we identified significant correlations in the gene expression of focal adhesion kinase and proline-rich tyrosine kinase (PTK2 and PTK2B) with NGFR (nerve growth factor receptor), PDGFRB (platelet-derived growth factor receptor B), EGFR (epithelial growth factor receptor), and CXCR1 (C-X-C motif chemokine receptor 1). This study further explores these correlations found

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Chen, Cui, Zhen Tao, Ya Li, Jie Li, and Yang Xu. "MicroRNA214 expression inhibits HCC cell proliferation through PTK2b/ Pyk2." Cellular and Molecular Biology 68, no. 1 (2022): 20–25. http://dx.doi.org/10.14715/cmb/2022.68.1.4.

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MicroRNAs (miRNAs/miRs) are crucial regulatory molecules that act as the most significantly downregulated microRNAs in hepatocellular carcinoma (HCC). PTK2b/Pyk2 is a non-receptor protein tyrosine kinase, which plays an important role in the development and metastasis of cancer. In this study, we explored the expression level and functional relationship between MicroRNA-214 (miR-214) and PTK2b/ Pyk2 in liver cancer cells. For this purpose, we analyzed the expression of miR-214 and PTK2b/Pyk2 in 38 cases of HCC and paired non-neoplastic tissue specimens using real-time PCR. MTT, cell cycle and

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Luo, Jinping, Lynda K. McGinnis, Carol Carlton, Hilary E. Beggs, and William H. Kinsey. "PTK2b function during fertilization of the mouse oocyte." Biochemical and Biophysical Research Communications 450, no. 3 (2014): 1212–17. http://dx.doi.org/10.1016/j.bbrc.2014.03.083.

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Zeng, Ying, Lu-Qi Peng, Mei Zhang, Rong Zhong, Ke-Chao Nie, and Wei Huang. "Identification of potential biomarkers and pathways related to major depressive disorder by integrated bioinformatic analysis and experimental validation." Asian Pacific Journal of Tropical Biomedicine 15, no. 5 (2025): 200–209. https://doi.org/10.4103/apjtb.apjtb_750_24.

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Objective: To identify promising biomarkers for the pathogenesis of major depressive disorder (MDD). Methods: Microarray chips of MDD patients, including the GSE98793, GSE52790, and GSE39653 datasets, were obtained from the Gene Expression Omnibus database. The biological processes and pathways related to MDD were investigated using the GO and KEGG pathway tools. Weighted gene coexpression network analysis was conducted to identify modules related to MDD. The hub genes associated with MDD were obtained via protein-protein interaction analysis. Finally, the expression of hub genes in the hippoc

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N'Songo, Aurelie, Minerva M. Carrasquillo, Xue Wang, et al. "African American exome sequencing identifies potential risk variants at Alzheimer disease loci." Neurology Genetics 3, no. 2 (2017): e141. http://dx.doi.org/10.1212/nxg.0000000000000141.

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Objective:In African Americans, we sought to systematically identify coding Alzheimer disease (AD) risk variants at the previously reported AD genome-wide association study (GWAS) loci genes.Methods:We identified coding variants within genes at the 20 published AD GWAS loci by whole-exome sequencing of 238 African American participants, validated these in 300 additional participants, and tested their association with AD risk in the combined cohort of 538 and with memory endophenotypes in 319 participants.Results:Two ABCA7 missense variants (rs3764647 and rs3752239) demonstrated significant ass

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Giralt, Albert, Benoit de Pins, Carmen Cifuentes-Díaz, et al. "PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease." Experimental Neurology 307 (September 2018): 62–73. http://dx.doi.org/10.1016/j.expneurol.2018.05.020.

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8

Ni, Bin, Jared S. Farrar, Shanshan Chen, Joseph C. Lownik, and Francesco S. Celi. "A novel role for PTK2B in cultured beige adipocyte differentiation." Biochemical and Biophysical Research Communications 501, no. 4 (2018): 851–57. http://dx.doi.org/10.1016/j.bbrc.2018.05.021.

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9

Liu, Yu, Dongfa Lin, Syeda Sadia Najam, et al. "Functional redundancy between glucocorticoid and mineralocorticoid receptors in mature corticotropin‐releasing hormone neurons protects from obesity." Obesity 32, no. 10 (2024): 1885–96. http://dx.doi.org/10.1002/oby.24116.

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AbstractObjectiveHere, we aimed to investigate the role of glucocorticoid and mineralocorticoid receptors (GRs and MRs, respectively) in the regulation of energy homeostasis.MethodsWe used three mouse models with simultaneous deletion of GRs and MRs in either forebrain neurons, the paraventricular nucleus, or corticotropin‐releasing hormone (CRH) neurons and compared them with wild‐type controls or isolated knockout groups. In addition to body weight, food intake, energy expenditure, insulin sensitivity, fat/lean mass distribution, and plasma corticosterone levels, we also performed transcript

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Chu, Weiwei, Lili Guan, Dihua Huang, Yuezhong Ren, and Yan Zhou. "Lovastatin exerts protective effects on endothelial cells via upregulation of PTK2B." Experimental and Therapeutic Medicine 12, no. 3 (2016): 1741–49. http://dx.doi.org/10.3892/etm.2016.3547.

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11

Piaggio, Francesca, Veronica Tozzo, Cinzia Bernardi, et al. "Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma." Cancers 11, no. 11 (2019): 1688. http://dx.doi.org/10.3390/cancers11111688.

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Background: Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating mutations in the genes G-protein subunit alpha Q (GNAQ), G-protein subunit alpha 11 (GNA11), cysteinyl leukotriene receptor 2 (CYSLTR2), and phospholipase C beta 4 (PLCB4) and by metastasis-promoting mutations in the genes splicing factor 3B1 (SF3B1), serine and arginine rich splicing factor 2 (SRSF2), and BRCA1-associated protein 1 (BAP1). Here, we tested the hypothesis that additional mutations, though occurring in only a few cases (“secondary drivers”), might influence tumor development. Methods: We an

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Liu, Zhen, Kai-Min Hao, Hao-Yu Wang, and Wen-Xiu Qi. "Histone deacetylase-6 modulates amyloid beta-induced cognitive dysfunction rats by regulating PTK2B." NeuroReport 31, no. 10 (2020): 754–61. http://dx.doi.org/10.1097/wnr.0000000000001481.

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13

Terao, Chikashi, Hajime Yoshifuji, Takayoshi Matsumura, et al. "Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis." Proceedings of the National Academy of Sciences 115, no. 51 (2018): 13045–50. http://dx.doi.org/10.1073/pnas.1808850115.

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Takayasu arteritis (TAK) is a systemic vasculitis with severe complications that affects the aorta and its large branches. HLA-B*52 is an established susceptibility locus to TAK. To date, there are still only a limited number of reports concerning non-HLA susceptibility loci to TAK. We conducted a genome-wide association study (GWAS) and a follow-up study in a total of 633 TAK cases and 5,928 controls. A total of 510,879 SNPs were genotyped, and 5,875,450 SNPs were imputed together with HLA-B*52. Functional annotation of significant loci, enhancer enrichment, and pathway analyses were conducte

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Tang, Nanyun, Kristin Leskoske, Krystine Garcia-Mansfield, et al. "CSIG-31. MULTI-OMICS TO EDGE INTO PRECISION MEDICINE FOR DIPG." Neuro-Oncology 23, Supplement_6 (2021): vi40. http://dx.doi.org/10.1093/neuonc/noab196.157.

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Abstract DIPG is an incurable pediatric brain tumor with 80% of patients harboring H3F3A (H3.3) mutation that substitutes methionine for lysine at position 27 (K27M), resulting in global depletion of H3.3K27 me3 (trimethylation). These histone mutations modify the epigenome and alter oncogenic transcription, causing oncogenic insults to progenitor cells in early neurodevelopment (1). To determine the reprogramming pathways in the cell context of H3.3K27M tumors, we conducted LC-MS based proteomic and phosphoproteomic analysis on seven patient-derived DIPG cell lines. Three normal neuronal stem

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15

Polis, Baruh, and Hava Gil-Henn. "Commentary on Giralt et al.: PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease." Experimental Neurology 311 (January 2019): 313–17. http://dx.doi.org/10.1016/j.expneurol.2018.08.011.

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16

Cong, Yanyan, Haibo Wu, Xuejiao Bian, et al. "Ptk2b deletion improves mice folliculogenesis and fecundity via inhibiting follicle loss mediated by Erk pathway." Journal of Cellular Physiology 236, no. 2 (2020): 1043–53. http://dx.doi.org/10.1002/jcp.29914.

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Kadoba, K., R. Watanabe, T. Iwasaki, et al. "POS0345 CLINICOGENETIC STUDY OF FIVE NOVEL SUSCEPTIBILITY LOCI FOR TAKAYASU ARTERITIS: SUSCEPTIBILITY LOCI IN THE IL12B AND PTK2B REGION, BUT NOT THE LILRA3, DUSP22, KLHL33 REGIONS, ARE ASSOCIATED WITH VASCULAR DAMAGE IN TAKAYASU ARTERITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 401.2–402. http://dx.doi.org/10.1136/annrheumdis-2021-eular.289.

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Background:We have previously identified single nucleotide polymorphism (SNP) rs6871626 in IL12B, rs103294 in LILRA3, rs17133698 in DUSP22, rs2322599 in PTK2B, and rs1713450 in KLHL33 as non-HLA susceptibility loci in Takayasu arteritis (TAK) [1, 2]. However, the association of these SNPs with clinical features has scarcely investigated.Objectives:In this study, we aimed to examine how these SNPs contribute to clinical features and vascular damage in TAK.Methods:We enrolled 99 TAK patients who were enrolled in our previous genome-wide association study (GWAS) [2]. To assess vascular damage, Ta

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Stumpf, Anita N., Edith D. van der Meijden, Cornelis A. M. van Bergen, Roelof Willemze, J. H. Frederik Falkenburg, and Marieke Griffioen. "Identification of Four New HLA Class II Restricted Minor Histocompatibility Antigens Contributing to Graft Versus Leukemia Reactivity." Blood 112, no. 11 (2008): 3247. http://dx.doi.org/10.1182/blood.v112.11.3247.3247.

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Abstract Patients with relapsed hematological malignancies after HLA-matched hematopoietic stem cell transplantation (HSCT) can be effectively treated with donor lymphocyte infusion (DLI). Donor-derived T cells mediate beneficial graft-versus-leukemia (GvL) effect but may also induce detrimental graft-versus-host disease (GvHD). These T cell responses are directed against polymorphic peptides which differ between patient and donor due to single nucleotide polymorphisms (SNPs). These so called minor histocompatibility antigens (mHag) are presented by HLA class I or II, thereby activating CD8+ a

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Allert, C., S. Zimmermann, S. Göllner, et al. "P382: PTK2B MEDIATES TYROSINE KINASE INHIBITOR DRUG RESISTANCE IN AML ASSOCIATED WITH ALTERED MIGRATION AND ADHESION PROPERTIES." HemaSphere 6 (June 2022): 282–83. http://dx.doi.org/10.1097/01.hs9.0000844416.17053.2a.

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Beck, Tim N., Emmanuelle Nicolas, Meghan C. Kopp, and Erica A. Golemis. "Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease." Oncoscience 1, no. 7 (2014): 486–503. http://dx.doi.org/10.18632/oncoscience.64.

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21

Li, Ya-Qing, Meng-Shan Tan, Hui-Fu Wang, et al. "Common variant in PTK2B is associated with late-onset Alzheimer’s disease: A replication study and meta-analyses." Neuroscience Letters 621 (May 2016): 83–87. http://dx.doi.org/10.1016/j.neulet.2016.04.020.

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22

Wang, Di, Yunkai Lin, Feihong Xu та ін. "SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis". eBioMedicine 85 (листопад 2022): 104278. http://dx.doi.org/10.1016/j.ebiom.2022.104278.

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23

Dourlen, P., F. J. Fernandez-Gomez, C. Dupont, et al. "Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology." Molecular Psychiatry 22, no. 6 (2016): 874–83. http://dx.doi.org/10.1038/mp.2016.59.

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Zhang, Lei, Rongrong Luo, Lin Wang, et al. "Prediction of EGFR-TKI efficacy in non-small cell lung cancer patients by metabolomics and genomics." Journal of Clinical Oncology 37, no. 15_suppl (2019): e20627-e20627. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e20627.

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e20627 Background: Metabolites and somatic mutations involved in EGFR-TKI efficacy remains unclear in non-small cell lung cancer (NSCLC) patients with EGFR sensitizing mutation (EGFRsm+). Here we performed a joint analysis of metabolomics and genomics data to identify metabolites and somatic mutations as biomarkers for EGFR-TKI efficacy. Methods: Metabolomic profiling of plasma samples (n = 43) from NSCLC patients with EGFRsm+, consisting of cohort A (n = 30) and B (n = 13), was conducted using UPLC or rapid separation LC-MS/MS. The 13 matched FFPE samples in cohort B were also used in the tar

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Bianchini, Laurence, Georges Maire, Bernard Guillot, et al. "Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion." Virchows Archiv 452, no. 6 (2008): 689–96. http://dx.doi.org/10.1007/s00428-008-0580-2.

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Astillero-Lopez, Veronica, Sandra Villar-Conde, Melania Gonzalez-Rodriguez, et al. "ROLE OF ANXA2, HSP90AA1 AND PTK2B IN SYNAPTIC HOMEOSTASIS THROUGH MICROGLIAL CELLS IN THE HUMAN ENTORHINAL CORTEX IN ALZHEIMER’S DISEASE." IBRO Neuroscience Reports 15 (October 2023): S361. http://dx.doi.org/10.1016/j.ibneur.2023.08.680.

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Xu, Chao, Jing Shi, Rufeng Huang, Zhengchang Wu, Shenglong Wu, and Wenbin Bao. "Transcriptome-Wide lncRNA and mRNA Profiling of Spleens from Meishan Pigs at Different Development Stages." Animals 12, no. 19 (2022): 2676. http://dx.doi.org/10.3390/ani12192676.

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Meishan is a well-established local Chinese breed known for its high fecundity, strong immune response and high meat quality. However, the molecular mechanism of immune regulation during the development of Meishan pigs still remains unclear. Here, we performed the transcriptional sequencing of spleen tissues from Meishan pigs at different development stages. In total, 10,268 lncRNAs were identified, including 1254 novel lncRNAs and 9014 known lncRNAs. Time series analysis revealed that genes of the up-regulated module were enriched in pathways associated with transport, immunity, and histone a

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Batissoco, Ana, Rodrigo Salazar-Silva, Jeanne Oiticica, Ricardo Bento, Regina Mingroni-Netto, and Luciana Haddad. "A Cell Junctional Protein Network Associated with Connexin-26." International Journal of Molecular Sciences 19, no. 9 (2018): 2535. http://dx.doi.org/10.3390/ijms19092535.

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GJB2 mutations are the leading cause of non-syndromic inherited hearing loss. GJB2 encodes connexin-26 (CX26), which is a connexin (CX) family protein expressed in cochlea, skin, liver, and brain, displaying short cytoplasmic N-termini and C-termini. We searched for CX26 C-terminus binding partners by affinity capture and identified 12 unique proteins associated with cell junctions or cytoskeleton (CGN, DAAM1, FLNB, GAPDH, HOMER2, MAP7, MAPRE2 (EB2), JUP, PTK2B, RAI14, TJP1, and VCL) by using mass spectrometry. We show that, similar to other CX family members, CX26 co-fractionates with TJP1, V

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Tasian, Sarah K., Mignon L. Loh, and Stephen P. Hunger. "Philadelphia chromosome–like acute lymphoblastic leukemia." Blood 130, no. 19 (2017): 2064–72. http://dx.doi.org/10.1182/blood-2017-06-743252.

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AbstractPhiladelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares significant overlap with that of Ph-positive (Ph+) ALL and is suggestive of activated kinase signaling. Although Ph+ ALL is defined by BCR-ABL1 fusion, Ph-like ALL cases contain a variety of genomic alterations that activate kinase and cytokine receptor signaling. These alterations can be grouped into major subclasses that include ABL-class fusions involving ABL1, ABL2, CSF1R, and PDGFRB that phenocopy BCR-ABL1 and

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Padhy, Biswajit, Bushra Hayat, Gargi Gouranga Nanda, Pranjya Paramita Mohanty, and Debasmita Pankaj Alone. "Pseudoexfoliation and Alzheimer's associated CLU risk variant, rs2279590 lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression." Canadian Journal of Biotechnology 1, Special Issue (2017): 90. http://dx.doi.org/10.24870/cjb.2017-a77.

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Kremer, A. N., J. C. van der Griendt, E. D. van der Meijden, et al. "Development of a coordinated allo T cell and auto B cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation." Haematologica 99, no. 2 (2013): 365–69. http://dx.doi.org/10.3324/haematol.2013.086652.

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Padhy, Biswajit, Bushra Hayat, Gargi Gouranga Nanda, Pranjya Paramita Mohanty, and Debasmita Pankaj Alone. "Pseudoexfoliation and Alzheimer’s associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression." Human Molecular Genetics 26, no. 22 (2017): 4519–29. http://dx.doi.org/10.1093/hmg/ddx329.

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Wang, Yang, Zhimin Chen, Fang You, Jing Sun, and Hongyi Yang. "PTK2B inhibitor PF-431396 inhibits inflammatory response and apoptosis of ovarian granulosa cells by targeting AKT1 phosphorylation in premature ovarian insufficiency." International Immunopharmacology 155 (May 2025): 114651. https://doi.org/10.1016/j.intimp.2025.114651.

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Racioppi, Luigi, Pamela Noeldner, Fumin Lin, Stephanie Arvai, and Anthony Means. "Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Regulates Macrophage-Mediated Inflammatory Responses (172.35)." Journal of Immunology 188, no. 1_Supplement (2012): 172.35. http://dx.doi.org/10.4049/jimmunol.188.supp.172.35.

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Abstract Calcium/calmodulin-dependent Kinase Kinase 2 (CaMKK2) plays a key role in regulating food intake and energy expenditure at least in part by its actions in hypothalamic neurons. Previously we showed that loss of CaMKK2 protected mice from high fat diet (HFD)-induced obesity and glucose intolerance. However, whereas pair-feeding HFD to WT mice to match food consumption of CAMKK2-null mice slowed weight gain, it failed to protect from glucose intolerance. Here we show that relative to WT mice, HFD-fed CaMKK2-null mice are protected from inflammation in adipose and remain glucose tolerant

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Prell, Andreas, Mustafa Orkun Sen, Ramya Potabattula, et al. "Species-Specific Paternal Age Effects and Sperm Methylation Levels of Developmentally Important Genes." Cells 11, no. 4 (2022): 731. http://dx.doi.org/10.3390/cells11040731.

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A growing number of sperm methylome analyses have identified genomic loci that are susceptible to paternal age effects in a variety of mammalian species, including human, bovine, and mouse. However, there is little overlap between different data sets. Here, we studied whether or not paternal age effects on the sperm epigenome have been conserved in mammalian evolution and compared methylation patterns of orthologous regulatory regions (mainly gene promoters) containing both conserved and non-conserved CpG sites in 94 human, 36 bovine, and 94 mouse sperm samples, using bisulfite pyrosequencing.

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Haas, Laura T., та Stephen M. Strittmatter. "Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease". Journal of Biological Chemistry 291, № 33 (2016): 17112–21. http://dx.doi.org/10.1074/jbc.m116.720664.

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The dysfunction and loss of synapses in Alzheimer disease are central to dementia symptoms. We have recently demonstrated that pathological Amyloid β oligomer (Aβo) regulates the association between intracellular protein mediators and the synaptic receptor complex composed of cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5). Here we sought to determine whether Aβo alters the physiological signaling of the PrPC-mGluR5 complex upon glutamate activation. We provide evidence that acute exposure to Aβo as well as chronic expression of familial Alzheimer disease mutant tr

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Thorne, Jacob W., Reid Redden, Scott A. Bowdridge, Gabrielle M. Becker, Morgan R. Stegemiller, and Brenda M. Murdoch. "Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes." Genes 14, no. 7 (2023): 1342. http://dx.doi.org/10.3390/genes14071342.

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The anthelmintic resistance of gastrointestinal nematodes (GINs) poses a significant threat to sheep worldwide, but genomic selection can serve as an alternative to the use of chemical treatment as a solution for parasitic infection. The objective of this study is to conduct genome-wide association studies (GWASs) to identify single nucleotide polymorphisms (SNPs) in Rambouillet (RA) and Dorper × White Dorper (DWD) lambs associated with the biological response to a GIN infection. All lambs were genotyped with a medium-density genomic panel with 40,598 markers used for analysis. Separate GWASs

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Beverdam, Annemiek, Terje Svingen, Stefan Bagheri-Fam, et al. "Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads." Developmental Dynamics 239, no. 10 (2010): 2735–41. http://dx.doi.org/10.1002/dvdy.22396.

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Crews, Leslie A., Larissa Balaian, Heather Leu, et al. "RNA Splicing Modulation Impairs Acute Myeloid Leukemia Stem Cell Maintenance." Blood 126, no. 23 (2015): 567. http://dx.doi.org/10.1182/blood.v126.23.567.567.

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Abstract Introduction Disease relapse is the leading cause of death in secondary AML (sAML), which evolves from antecedent hematologic disorders like myelodysplastic syndrome (MDS) or myeloproliferative neoplasms (MPNs) or following exposure to chemotherapy. Persistence of therapy-resistant leukemia stem cells (LSC) harboring enhanced survival and self-renewal capacity has been linked to high relapse rates in sAML. Previously, we showed that missplicing of a stem cell regulatory gene, GSK3 b, and splice isoform switching favoring pro-survival BCL2 family isoform expression promoted generation

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Schmitt, Anthony, Shadi Melnyk, Kristin Sikkink, et al. "Abstract LB122: Arima-HiC sequencing accurately detects clinically-relevant structural variants in pediatric leukemia samples." Cancer Research 83, no. 8_Supplement (2023): LB122. http://dx.doi.org/10.1158/1538-7445.am2023-lb122.

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Abstract Genetic structural variants (SVs), especially those leading to gene fusions, are well-known oncogenic drivers. These SVs can produce overexpression or loss-of-function of certain genes, or generate chimeric fusion proteins. Thus, they serve as important disease biomarkers across several cancers and can also represent therapeutically targetable alterations. Detecting these SVs at a gene-level resolution can be challenging with lower resolution karyotyping approaches, or even RNA sequencing approaches, due to difficulties with culture, sample stability, low transcript abundance, or low-

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Li, Ya-Qing, Meng-Shan Tan, Hui-Fu Wang, et al. "Corrigendum to “Common variant in PTK2B is associated with late-onset Alzheimer’s disease: A replication study and meta-analyses” [Neurosci. Lett. 621 (2016) 83–87]." Neuroscience Letters 626 (July 2016): 182. http://dx.doi.org/10.1016/j.neulet.2016.05.023.

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Li, Xingming, Yuliang Cheng, Jiayi Li, Chang Liu, He Qian та Genyi Zhang. "Torularhodin Alleviates Hepatic Dyslipidemia and Inflammations in High-Fat Diet-Induced Obese Mice via PPARα Signaling Pathway". Molecules 27, № 19 (2022): 6398. http://dx.doi.org/10.3390/molecules27196398.

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Torularhodin is a β-carotene-like compound from Sporidiobolus pararoseus, and its protective effect against high-fat diet (HFD)-induced hepatic dyslipidemia and inflammation was investigated. Compared to mice of C57BL/6J fed on HFD, the addition of Torularhodin into the HFD (HFD-T) significantly reduced body weight, serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and the inflammatory mediators of TNF-α, IL-6, IL-1β, and lipopolysaccharide (LPS). A significant increase of high-density lipoprotein cholesterol (HDL-c), which is beneficial to cholesterol clearance,

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Detroja, Trishna Saha, Hava Gil-Henn, and Abraham O. Samson. "Text-Mining Approach to Identify Hub Genes of Cancer Metastasis and Potential Drug Repurposing to Target Them." Journal of Clinical Medicine 11, no. 8 (2022): 2130. http://dx.doi.org/10.3390/jcm11082130.

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Metastasis accounts for the majority of cancer-related deaths. Despite decades of research, the prevention and suppression of metastasis remain an elusive goal, and to date, only a few metastasis-related genes have been targeted therapeutically. Thus, there is a strong need to find potential genes involved in key driver traits of metastasis and their available drugs. In this study, we identified genes associated with metastasis and repurposable drugs that potentially target them. First, we use text mining of PubMed citations to identify candidate genes associated with metastatic processes, suc

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Xu, Qili, Aili Song, and Qigui Xie. "The Integrated Analyses of Driver Genes Identify Key Biomarkers in Thyroid Cancer." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382094044. http://dx.doi.org/10.1177/1533033820940440.

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Aim: Thyroid cancer is the most common endocrine cancer, the incidence rate has continuously increased worldwide. However, there are still lack of effective molecular biomarkers for the diagnosis and treatment of the disease. The study was conducted to identify driver genes that may serve as potential biomarkers for the disease. Methods: The computational tools oncodriveCLUST, oncodriveFM, icages and drgap were used to detect driver genes in thyroid cancer using somatic mutations from The Cancer Genome Atlas database. Integrated analyses were performed on the driver genes using multiomics data

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Shah, Manasvi S., Scott L. Schwartz, Chen Zhao, et al. "Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet." Physiological Genomics 43, no. 10 (2011): 640–54. http://dx.doi.org/10.1152/physiolgenomics.00213.2010.

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We have recently demonstrated that nutritional bioactives (fish oil and pectin) modulate microRNA molecular switches in the colon. Since integrated analysis of microRNA and mRNA expression at an early stage of colon cancer development is lacking, in this study, four computational approaches were utilized to test the hypothesis that microRNAs and their posttranscriptionally regulated mRNA targets, i.e., both total mRNAs and actively translated mRNA transcripts, are differentially modulated by carcinogen and diet treatment. Sprague-Dawley rats were fed diets containing corn oil ± fish oil with p

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Stavchansky, Vasily V., Ivan B. Filippenkov, Julia A. Remizova, et al. "Insight into Glyproline Peptides’ Activity through the Modulation of the Inflammatory and Neurosignaling Genetic Response Following Cerebral Ischemia–Reperfusion." Genes 13, no. 12 (2022): 2380. http://dx.doi.org/10.3390/genes13122380.

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Glyprolines are Gly-Pro (GP)- or Pro-Gly (PG)-containing biogenic peptides. These peptides can act as neutrophil chemoattractants, or atheroprotective, anticoagulant, and neuroprotective agents. The Pro-Gly-Pro (PGP) tripeptide is an active factor of resistance to the biodegradation of peptide drugs. The synthetic Semax peptide, which includes Met-Glu-His-Phe (MEHF) fragments of adrenocorticotropic hormone and the C-terminal tripeptide PGP, serves as a neuroprotective drug for the treatment of ischemic stroke. Previously, we revealed that Semax mostly prevented the disruption of the gene expre

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Tawa, Gregory J., John Braisted, David Gerhold, et al. "Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species." PLOS Computational Biology 17, no. 9 (2021): e1009450. http://dx.doi.org/10.1371/journal.pcbi.1009450.

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Understanding relationships between spontaneous cancer in companion (pet) canines and humans can facilitate biomarker and drug development in both species. Towards this end we developed an experimental-bioinformatic protocol that analyzes canine transcriptomics data in the context of existing human data to evaluate comparative relevance of canine to human cancer. We used this protocol to characterize five canine cancers: melanoma, osteosarcoma, pulmonary carcinoma, B- and T-cell lymphoma, in 60 dogs. We applied an unsupervised, iterative clustering method that yielded five co-expression module

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Wang, Yan, Zhongyv Xiong, Chang Li, et al. "Multiple Beneficial Effects of Aloesone from Aloe vera on LPS-Induced RAW264.7 Cells, Including the Inhibition of Oxidative Stress, Inflammation, M1 Polarization, and Apoptosis." Molecules 28, no. 4 (2023): 1617. http://dx.doi.org/10.3390/molecules28041617.

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Aloesone is a major metabolic compound in Aloe vera, which has been widely used as a food source and therapeutic agent in several countries. Our recent study demonstrated that aloesone has anti-epileptic effects on glutamate-induced neuronal injury by suppressing the production of reactive oxygen species (ROS). Unless ROS are naturally neutralized by the endogenous antioxidant system, they lead to the activation of inflammation, polarization, and apoptosis. This study aimed to identify the multiple beneficial effects of aloesone and explore its molecular mechanism in macrophages. Hence, the mu

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Chheda, Milan, Jingxian Liu, Song Cao, et al. "EPCO-53. MULTI-SCALE REGULATION OF SIGNALING CASCADES AND TUMOR EVOLUTION IN HIGH GRADE ASTROCYTOMAS." Neuro-Oncology 25, Supplement_5 (2023): v136. http://dx.doi.org/10.1093/neuonc/noad179.0515.

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Abstract The National Cancer Institute Clinical Proteomic Atlas Consortium (CPTAC) herein reports our deep characterization of 228 grade IV IDH1 WT and mutant astrocytomas (including 28 matched primary and recurrent GBMs) using 15 proteogenomic and metabolomic platforms. Major advances over our first CPTAC GBM report (Wang et al., 2021, Cancer Cell), are the inclusion of many more samples including paired primary and recurrent tumors, application of new platforms, including glycoproteomics and targeted mass spectrometry methods, development and application of new computational techniques, and

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Wei, Yicong, Keming Qi, Yi Yu, et al. "Analysis of Differentially Expressed Genes in the Dentate Gyrus and Anterior Cingulate Cortex in a Mouse Model of Depression." BioMed Research International 2021 (February 11, 2021): 1–17. http://dx.doi.org/10.1155/2021/5013565.

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Major depressive disorder (MDD) is a prevalent, chronic, and relapse-prone psychiatric disease. However, the intermediate molecules resulting from stress and neurological impairment in different brain regions are still unclear. To clarify the pathological changes in the dentate gyrus (DG) and anterior cingulate cortex (ACC) regions of the MDD brain, which are the most closely related to the disease, we investigated the published microarray profile dataset GSE84183 to identify unpredictable chronic mild stress- (UCMS-) induced differentially expressed genes (DEGs) in the DG and ACC regions. Bas

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