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Journal articles on the topic 'PTLP'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Verma, Anita, Anissa M. Cheung, and Drusilla L. Burns. "Stabilization of the Pertussis Toxin Secretion Apparatus by the C Terminus of PtlD." Journal of Bacteriology 190, no. 21 (2008): 7285–90. http://dx.doi.org/10.1128/jb.01106-08.

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ABSTRACT Pertussis toxin (PT) is secreted from Bordetella pertussis by a type IV secretion system, known as the Ptl transporter, that comprises nine different proteins, PtlA to PtlI. In this study, we found that PtlD is required for the stability of three Ptl proteins, PtlE, PtlF, and PtlH. A region limited to the C-terminal 72 amino acids of PtlD (amino acids 392 to 463) was sufficient for maintaining the stability of PtlE, PtlF, and PtlH, although this region was not sufficient to support secretion of the toxin. Further analysis demonstrated that a stretch of 10 amino acids at the C-terminal

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2

Verma, Anita, and Drusilla L. Burns. "Requirements for Assembly of PtlH with the Pertussis Toxin Transporter Apparatus of Bordetella pertussis." Infection and Immunity 75, no. 5 (2007): 2297–306. http://dx.doi.org/10.1128/iai.00008-07.

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ABSTRACT PtlH is an essential component of the Ptl system, the type IV transporter responsible for secretion of pertussis toxin (PT) across the outer membrane of Bordetella pertussis. The nine Ptl proteins are believed to interact to form a membrane-spanning apparatus through which the toxin is secreted. In this study, we monitored the subcellular localization of PtlH in strains of B. pertussis lacking PT, lacking other Ptl proteins, or from which ATP has been depleted in order to gain insight into the requirements for assembly of PtlH with the remainder of the Ptl transporter complex that is

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3

Cook, Grant O., and Carl D. Sorensen. "Overview of transient liquid phase and partial transient liquid phase bonding." Journal of Materials Science 46, no. 16 (2011): 5305–23. http://dx.doi.org/10.1007/s10853-011-5561-1.

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AbstractTransient liquid phase (TLP) bonding is a relatively new bonding process that joins materials using an interlayer. On heating, the interlayer melts and the interlayer element (or a constituent of an alloy interlayer) diffuses into the substrate materials, causing isothermal solidification. The result of this process is a bond that has a higher melting point than the bonding temperature. This bonding process has found many applications, most notably the joining and repair of Ni-based superalloy components. This article reviews important aspects of TLP bonding, such as kinetics of the pr

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4

Rambow-Larsen, Amy A., and Alison A. Weiss. "The PtlE Protein of Bordetella pertussis Has Peptidoglycanase Activity Required for Ptl-Mediated Pertussis Toxin Secretion." Journal of Bacteriology 184, no. 11 (2002): 2863–69. http://dx.doi.org/10.1128/jb.184.11.2863-2869.2002.

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ABSTRACT Pertussis toxin of Bordetella pertussis is secreted by a type IV secretion system comprised of the products of the nine ptl (pertussis toxin liberation) genes. These proteins are believed to form a complex spanning both the inner and outer membranes and passing through the peptidoglycan layer. Peptidoglycan acts as a barrier for transport through the periplasm of large folded molecules. Assembled pertussis toxin and the secretion component proteins PtlC through PtlH are too large to diffuse through intact peptidoglycan. Therefore, we hypothesized that the Ptl system contains a peptido

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5

Iino, Y. "Partial Transient Liquid Phase Metals Layer-Surface Coating for Improved Oxidation Resistance and Low Cycle Fatigue Crack Initiation Life at 1073K in Air of TiAl Alloy." Key Engineering Materials 577-578 (September 2013): 309–12. http://dx.doi.org/10.4028/www.scientific.net/kem.577-578.309.

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The partial transient liquid phase PTLP metals layer technique for ceramic-metal bonding was applied to surface coating of TiAl alloy. Ni/Al/Ni and Ni/Ti/Ni foils (10μm) layers were coated on flat surface of oxidation specimen OS and on notch root surface of notched compact tension specimen NCT of a TiAl alloy. It is shown that the oxidation resistance is significantly improved and that the resistance to the low cycle fatigue LCF crack initiation life is improved. A procedure of application of the present technique for three dimensional surface coating is proposed.

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6

KONG, H., E. PARK, B. NAM, et al. "A C-type lectin like-domain (CTLD)-containing protein (PtLP) from the swimming crab Portunus trituberculatus." Fish & Shellfish Immunology 25, no. 3 (2008): 311–14. http://dx.doi.org/10.1016/j.fsi.2008.05.003.

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7

Zhang, J. X., R. S. Chandel, and H. P. Seow. "PTLP Joining of Al2O3‐Stainless Steel 304 Using Ni‐Cr Foil—The Microstructure Morphologies of Joint Interfaces." Materials and Manufacturing Processes 18, no. 2 (2003): 181–93. http://dx.doi.org/10.1081/amp-120018904.

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8

Cangi, R., and D. A Atalay. "Effects of different bud loading levels on the yield, leaf and fruit characteristics of Hayward kiwifruit." Horticultural Science 33, No. 1 (2011): 23–28. http://dx.doi.org/10.17221/3736-hortsci.

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The effects of different levels of bud loading on the yield and some leaf and fruit characteristics in Hayward cultivar (A. deliciosa) in the province of Ordu, Turkey were examined during two growing seasons in 2000&ndash;2001. Six years old kiwifruit vines were pruned to carry the loads of 120, 180, 240 or 300 buds/vine on the canes with 12 buds. The study determined probable total leaf area (PTLA), probable total leaf number (PTLN), probable total leaf weight (PTLW) and yield per vine. Mean fruit weight (MFW) and soluble solid contents (SSC, %) of fruits were expressed. In addition, unit

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9

Zhang, J. X., R. S. Chandel, Y. Z. Chen, and H. P. Seow. "Effect of residual stress on the strength of an alumina–steel joint by partial transient liquid phase (PTLP) brazing." Journal of Materials Processing Technology 122, no. 2-3 (2002): 220–25. http://dx.doi.org/10.1016/s0924-0136(02)00010-9.

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10

Siggins, S., K. Tanhuanpaa, M. Jauhiainen, C. Ehnholm, and V. M. Olkkonen. "4P-1028 HEPG2 cells provide evidence for an intracellular role of phospholipid transfer protein (PTLP) in lipoprotein assembly/secretion." Atherosclerosis Supplements 4, no. 2 (2003): 300. http://dx.doi.org/10.1016/s1567-5688(03)91285-2.

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11

Zhang, Chunguang, Guanjun Qiao, and Zhihao Jin. "Active brazing of pure alumina to Kovar alloy based on the partial transient liquid phase (PTLP) technique with Ni–Ti interlayer." Journal of the European Ceramic Society 22, no. 13 (2002): 2181–86. http://dx.doi.org/10.1016/s0955-2219(02)00011-0.

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12

Cook, Grant O., and Carl D. Sorensen. "Partial Transient Liquid-Phase Bonding, Part I: A Novel Selection Procedure for Determining Ideal Interlayer Combinations, Validated Against Al2O3 PTLP Bonding Experience." Metallurgical and Materials Transactions A 44, no. 13 (2013): 5732–53. http://dx.doi.org/10.1007/s11661-013-1956-8.

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13

Zhang, Xin, Xiaohong Shi, Jie Wang, Hejun Li, Kezhi Li, and Yancai Ren. "Effect of Bonding Temperature on the Microstructures and Strengths of C/C Composite/GH3044 Alloy Joints by Partial Transient Liquid-Phase (PTLP) Bonding with Multiple Interlayers." Acta Metallurgica Sinica (English Letters) 27, no. 4 (2014): 663–69. http://dx.doi.org/10.1007/s40195-014-0090-y.

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14

Carroll, Elizabeth C., Shai Berlin, Joshua Levitz, et al. "Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics." Proceedings of the National Academy of Sciences 112, no. 7 (2015): E776—E785. http://dx.doi.org/10.1073/pnas.1416942112.

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Mammalian neurotransmitter-gated receptors can be conjugated to photoswitchable tethered ligands (PTLs) to enable photoactivation, or photoantagonism, while preserving normal function at neuronal synapses. “MAG” PTLs for ionotropic and metabotropic glutamate receptors (GluRs) are based on an azobenzene photoswitch that is optimally switched into the liganding state by blue or near-UV light, wavelengths that penetrate poorly into the brain. To facilitate deep-tissue photoactivation with near-infrared light, we measured the efficacy of two-photon (2P) excitation for two MAG molecules using nonli

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15

Squire, Teresa L., Mark E. Lowe, Vernon W. Bauer, and Matthew T. Andrews. "Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression." Physiological Genomics 16, no. 1 (2003): 131–40. http://dx.doi.org/10.1152/physiolgenomics.00168.2002.

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Thirteen-lined ground squirrels ( Spermophilus tridecemlineatus) exploit the low-temperature activity of pancreatic triacylglycerol lipase (PTL) during hibernation. Lipolytic activity at body temperatures associated with hibernation was examined using recombinant ground squirrel and human PTLs expressed in yeast. Both the human and ground squirrel enzymes displayed high activity at temperatures as low as 0°C and showed Q10 values of 1.2–1.5 over a range of 37–7°C. These studies indicate that low-temperature lipolysis is a general property of PTL and does not require protein modifications uniqu

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16

Chapuy, Bjoern, Margaretha GM Roemer, Yuxiang Tan, et al. "Actionable Genetic Features of Primary Testicular and Primary Central Nervous System Lymphomas." Blood 124, no. 21 (2014): 74. http://dx.doi.org/10.1182/blood.v124.21.74.74.

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Abstract Introduction. Primary testicular lymphoma (PTL) and primary central nervous system lymphoma (PCNSL) are large B-cell lymphomas (LBCL) that occur in immune privileged (IP) sites and share certain clinical and molecular features. To date, the treatment of these IP lymphomas is largely empiric and more effective targeted therapies are needed. Methods. To define actionable genetic features of IP lymphomas, we performed comprehensive genomic analyses of 21 PCNSLs and 7 PTLs and validated specific alterations in an independent cohort of 43 additional PTLs. Recurrent copy number alterations

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17

Wang, Huating, Nicholas J. Machesky, and Louis M. Mansky. "Both the PPPY and PTAP Motifs Are Involved in Human T-Cell Leukemia Virus Type 1 Particle Release." Journal of Virology 78, no. 3 (2004): 1503–12. http://dx.doi.org/10.1128/jvi.78.3.1503-1512.2004.

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ABSTRACT In retroviruses, the late (L) domain has been defined as a conserved motif in the Gag polyprotein precursor that, when mutated, leads to the emergence of virus particles that fail to pinch off from the plasma membrane. These domains have been observed to contain the PPXY, PTAP, or YXXL motifs. The deltaretroviruses, which include bovine leukemia virus (BLV) and human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2, have a conserved PPPY motif in the C-terminal region of the matrix (MA) domain of Gag, while HTLV-1 also encodes a PTAP motif in MA. In this study, we analyzed the roles o

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18

Wang, Jie, Guanzhong Yang, Fuqi Zhang, Yanlin Xiong, and Qinglian Xiong. "The preparation and mechanical properties of carbon/carbon (C/C) composite and carbon fiber reinforced silicon carbide (Cf/SiC) composite joint by partial transient liquid phase (PTLP) diffusion bonding process." Vacuum 158 (December 2018): 113–16. http://dx.doi.org/10.1016/j.vacuum.2018.09.045.

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19

Travaglino, Antonio, Mirella Pace, Silvia Varricchio, et al. "Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma." American Journal of Clinical Pathology 153, no. 2 (2019): 156–64. http://dx.doi.org/10.1093/ajcp/aqz145.

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Abstract Objectives To assess the prevalence of Hashimoto thyroiditis (HT) in primary thyroid lymphoma (PTL) and whether it differs between mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBCL). Methods Electronic databases were searched for studies assessing HT prevalence in PTL, based on antithyroid antibodies, clinical history, or pathology. Pooled prevalence of HT and its association with histotype (MALT or DLBCL) were calculated. Results Thirty-eight studies with 1,346 PTLs were included. Pooled prevalence results were 78.9% (any HT evidence), 65.3% (

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20

Farizo, Karen M., Thomas G. Cafarella, and Drusilla L. Burns. "Evidence for a Ninth Gene,ptlI, in the Locus Encoding the Pertussis Toxin Secretion System ofBordetella pertussisand Formation of a PtlI-PtlF Complex." Journal of Biological Chemistry 271, no. 49 (1996): 31643–49. http://dx.doi.org/10.1074/jbc.271.49.31643.

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21

Rambow-Larsen, Amy A., and Alison A. Weiss. "Temporal Expression of Pertussis Toxin and Ptl Secretion Proteins by Bordetella pertussis." Journal of Bacteriology 186, no. 1 (2004): 43–50. http://dx.doi.org/10.1128/jb.186.1.43-50.2004.

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ABSTRACT Pertussis toxin is an AB5 toxin comprised of protein subunits S1 through S5. The individual subunits are secreted by a Sec-dependent mechanism into the periplasm, where the toxin is assembled. The Ptl type IV secretion system mediates secretion of assembled toxin past the outer membrane. In this study, we examined the time course of protein expression, toxin assembly, and secretion as a function of the bacterial growth cycle. Logarithmic growth was observed after a 1-h lag phase. Secreted toxin was first observed at 3 h. Secretion continued throughout the logarithmic growth phase and

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22

Dreher, Paulette Cutruzzula, Jessica M. Fazendin, Kelly Lurz, Daniel C. Edwards, Stephen Guy, and Melanie Amster. "Painful angiomyxoid tumor in a failed renal allograft presenting as post-transplant lymphoproliferative disorder." Journal of Nephropathology 9, no. 2 (2019): e20-e20. http://dx.doi.org/10.34172/jnp.2020.20.

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Introduction: There exist few reports of de novo tumors involving an allograft kidney, and to the best of our knowledge there are only two previous reports of angiomyxoma Case Presentation: A 53-year-old Caucasian male with end-stage renal disease (ESRD) on hemodialysis (HD) secondary to malakoplakia with three failed prior renal transplants presented for repeat transplant evaluation. Imaging demonstrated a mass of the transplanted kidney suggestive of posttransplant lymphoproliferative disease (PTLPD). A biopsy was obtained revealing a predominance of myxoid material. The patient became incre

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23

Patel, Ami, Manisha Kintali, Gohar Mosoyan, Ronald Hoffman, and Camelia Iancu-Rubin. "Infusion of a Cryopreservable Human Megakaryocyte-Biased Cell Product Results in Sustained Platelet Reconstitution In Vivo." Blood 132, Supplement 1 (2018): 117. http://dx.doi.org/10.1182/blood-2018-99-118682.

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Abstract The demand for platelet (PTL) transfusions has steadily increased, straining a supply that is limited by its dependency on donors, short lifespan, risk of infections and alloimmunization. This stimulated the search for alternative PTL sources including PTLs generated ex vivo from primary CD34+ cells and immortalized pluripotent stem cells. These approaches, however, are associated with obstacles such as scalability and encounter identical limitations as donor PTLs: short shelf life, storage at ambient temperature and limited lifespan after infusion. These obstacles lead us to focus ou

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Bengtson, Charlotta, and Annemie Bogaerts. "The Quest to Quantify Selective and Synergistic Effects of Plasma for Cancer Treatment: Insights from Mathematical Modeling." International Journal of Molecular Sciences 22, no. 9 (2021): 5033. http://dx.doi.org/10.3390/ijms22095033.

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Cold atmospheric plasma (CAP) and plasma-treated liquids (PTLs) have recently become a promising option for cancer treatment, but the underlying mechanisms of the anti-cancer effect are still to a large extent unknown. Although hydrogen peroxide () has been recognized as the major anti-cancer agent of PTL and may enable selectivity in a certain concentration regime, the co-existence of nitrite can create a synergistic effect. We develop a mathematical model to describe the key species and features of the cellular response toward PTL. From the numerical solutions, we define a number of dependen

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Rahmanov, Nariman, Osman Ilyasov, and Huseyngulu Guliyev. "Application of voltage phase angle control in power system with unevenly loaded supply network." E3S Web of Conferences 216 (2020): 01050. http://dx.doi.org/10.1051/e3sconf/202021601050.

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In real power system situations of uneven loading of supply lines included in the section, forming connection between the source and the power system or separate dedicated load node, often occur. In such situations one of power transmission lines (PTL) will be loaded below the nominal installed capacity, while the other parallel communication line will be overloaded. Elimination of uneven load in PTL can be performed by the phase angle control between the voltages at the beginning and end of the connection. One of the effective means for the phase angle control is a phase-shifting transformer

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Altaf, Haashir, Nicole Vorhauer, Evangelos Tsotsas, and Tanja Vidaković-Koch. "Steady-State Water Drainage by Oxygen in Anodic Porous Transport Layer of Electrolyzers: A 2D Pore Network Study." Processes 8, no. 3 (2020): 362. http://dx.doi.org/10.3390/pr8030362.

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Recently, pore network modelling has been attracting attention in the investigation of electrolysis. This study focuses on a 2D pore network model with the purpose to study the drainage of water by oxygen in anodic porous transport layers (PTL). The oxygen gas produced at the anode catalyst layer by the oxidation of water flows counter currently to the educt through the PTL. When it invades the water-filled pores of the PTL, the liquid is drained from the porous medium. For the pore network model presented here, we assume that this process occurs in distinct steps and applies classical rules o

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Santos, Maria T., Juana Valles, Maria P. Fuset, et al. "Aspirin Down-Regulation of Platelet Reactivity in Patients with Acute Coronary Syndrome: Effects of Erythrocytes." Blood 104, no. 11 (2004): 1865. http://dx.doi.org/10.1182/blood.v104.11.1865.1865.

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Abstract Platelet-erythrocyte interactions enhance platelet reactivity (Santos et al.J Clin Invest1991;87:571;Valles et al. Blood2002; 99:3978) and reduce the effect of aspirin (ASA) as antithrombotic modality (Santos et al. Circulation1997;95:63; Valles et al.Circulation1998;97:350). These effects were studied using an experimental approach which independently evaluates platelet activation (TXA2, 5HT release) and recruitment (proaggregatory activity of cell-free releasates) during cell-cell interactions between erythrocytes (RBCs) and collagen-stimulated platelets (PTLs) or in whole blood (WB

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Fong, Helen, Goar Mosoyan, Ami Patel, Ronald Hoffman, Jay Tong, and Camelia Iancu-Rubin. "Preclinical Development of a Cryopreservable Megakaryocyte Cell Product from Cord Blood Derived Hematopoietic Stem Cells." Blood 128, no. 22 (2016): 3859. http://dx.doi.org/10.1182/blood.v128.22.3859.3859.

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Abstract Platelet (PTL) transfusions are currently the most effective treatment for patients with thrombocytopenia. Demand for PTL transfusions has steadily increased in recent years, straining a PTL supply that is already limited due to dependency on volunteer donors, short shelf life, risk of infections, and alloimmunization. This dilemma has stimulated the search for alternative approaches for generating PTLs ex vivo from different sources of hematopoietic stem cells (HSCs). Although PTLs have been successfully generated in cultures initiated with primary human CD34+ cells and pluripotent s

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Enblad, Gunilla, Hans Hagberg, Martin Erlanson, et al. "A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas." Blood 103, no. 8 (2004): 2920–24. http://dx.doi.org/10.1182/blood-2003-10-3389.

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Abstract Patients with peripheral T-cell lymphomas (PTLs) have an extremely poor prognosis when relapsed or refractory to conventional chemotherapy. We have studied alemtuzumab, a humanized anti-CD52 monoclonal antibody, as therapy for patients with heavily pretreated and refractory PTL. Fourteen patients entered the study. All had clinical stage III or IV disease. Patients received a rapidly escalating dosage of alemtuzumab during the first week and, thereafter, 30 mg intravenously 3 times per week for a maximum of 12 weeks. Trimethoprim/sulphamethoxazole and valaciclovir prophylaxis was give

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Maecker-Kolhoff, B., and C. Klein. "Das pädiatrische PTLD-Register (Ped-PTLD-Register)." Der Nephrologe 4, no. 4 (2009): 339–44. http://dx.doi.org/10.1007/s11560-009-0306-8.

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31

Lee, Seokyung, Young Ju Lee, Jae Hyung Kim, and Gi-Ja Lee. "Electrochemical Detection of H2O2 Released from Prostate Cancer Cells Using Pt Nanoparticle-Decorated rGO–CNT Nanocomposite-Modified Screen-Printed Carbon Electrodes." Chemosensors 8, no. 3 (2020): 63. http://dx.doi.org/10.3390/chemosensors8030063.

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In this study, we fabricated platinum nanoparticles (PtNP)-decorated, porous reduced graphene oxide (rGO)–carbon nanotube (CNT) nanocomposites on a PtNP-deposited screen-printed carbon electrode (PtNP/rGO–CNT/PtNP/SPCE) for detection of hydrogen peroxide (H2O2), which is released from prostate cancer cells LNCaP. The PtNP/rGO–CNT/PtNP/SPCE was fabricated by a simple electrochemical deposition and co-reduction method. In addition, the amperometric response of the PtNP/rGO–CNT/PtNP/SPCE electrode was evaluated through consecutive additions of H2O2 at an applied potential of 0.2 V (vs. Ag pseudo-

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Vakiani, Efsevia, Katia Basso, Ulf Klein, Riccardo Dalla-Favera, Laura Pasqualucci, and Govind Bhagat. "Gene Expression Analysis of B-Cell Post Transplant Lymphoproliferative Disorders Provides Insights into Disease Biology." Blood 110, no. 11 (2007): 3172. http://dx.doi.org/10.1182/blood.v110.11.3172.3172.

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Abstract Background: B-cell post transplant lymphoproliferative disorders (PTLDs) encompass a diverse group of entities, the majority representing EBV-driven lymphoproliferations, which arise in the setting of iatrogenic immunosuppression. Their pathogenesis, especially the genetic relationship of PTLD with other types of B-cell non-Hodgkin lymphomas (B-NHLs), is not well understood and the association of polymorphic PTLD (P-PTLD) with monomorphic PTLD (M-PTLD) is presently unclear. Thus, in order to address these issues we analyzed gene expression profiles of PTLD and compared them with those

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Semakula;, Barbara, Jon V. Rittenbach, and Jun Wang. "Hodgkin Lymphoma–like Posttransplantation Lymphoproliferative Disorder." Archives of Pathology & Laboratory Medicine 130, no. 4 (2006): 558–60. http://dx.doi.org/10.5858/2006-130-558-hlpld.

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Abstract Posttransplantation lymphoproliferative disorders (PTLD) are a heterogeneous group of monoclonal or polyclonal lymphoproliferative lesions that occur in immunosuppressed recipients following solid organ or bone marrow transplantation, including 4 categories: (1) early lesions (reactive plasmacytic hyperplasia, and infectious-mononucleosis–like PTLD), (2) polymorphic PTLD, (3) monomorphic PTLD (including B-cell neoplasms and T-cell neoplasms), and (4) Hodgkin lymphoma (HL) and HL-like PTLD in the current World Health Organization classification. Although HL-like PTLD has been grouped w

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Blackman, M. J. R. "PTDLP seminar." World Patent Information 25, no. 3 (2003): 261–62. http://dx.doi.org/10.1016/s0172-2190(03)00071-1.

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Alegre, Maria-Luisa. "Preventing PTLD?" American Journal of Transplantation 18, no. 7 (2018): 1583. http://dx.doi.org/10.1111/ajt.14955.

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Haider, Mobeen Zaka, Zarlakhta Zamani, Fnu Kiran, et al. "A systematic review of post-transplant lymphoproliferative disorder after lung transplant." Journal of Clinical Oncology 39, no. 15_suppl (2021): e19046-e19046. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e19046.

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e19046 Background: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after solid organ transplantation. This study aims to explore the association of PTLD diagnosed after lung transplant with infectious agents and immunosuppression regimen, explore types of PTLD, and their outcome. Methods: Following the PRISMA guideline, we searched the literature on PubMed, Cochrane, Embase, and clinicaltrials.gov. 1741 articles were screened and included five studies. Results: We analyzed data from five studies, n=13,643 transplant recipients with n=287 (2.10%) developed PTLD. Fo

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Capello, Daniela, Giuliana Muti, Michaela Cerri, et al. "Molecular Analysis of Posttransplant Lymphoproliferative Disorders (PTLD) of Donor Origin Occuring in Liver Transplant Patients." Blood 106, no. 11 (2005): 1916. http://dx.doi.org/10.1182/blood.v106.11.1916.1916.

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Abstract Most PTLD occurring in solid organ patients arise from recipient cells, whereas few cases derive from donor transplanted lymphocytes. Donor-derived PTLD usually have a predilection for the allograft and are particularly frequent following liver transplant. To clarify the histogenesis and pathogenesis of donor-derived PTLD, we investigated 11 monoclonal PTLD occurring in liver transplant patients, including 6 cases arising from donor cells and 5 cases from recipient cells. Phenotypic markers of histogenesis included expression of BCL6, MUM1 and CD138, which segregate the germinal cente

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Stubbins, Ryan J., Anthea C. Peters, Mabilang Curtis, et al. "Morphologic Evolution in Post-Transplant Lymphoproliferative Disorders (PTLD): A Clinicopathologic Case Series." Blood 126, no. 23 (2015): 5008. http://dx.doi.org/10.1182/blood.v126.23.5008.5008.

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Abstract Post-transplant lymphoproliferative disorders (PTLDs) are classified as early PTLDs (E-PTLD), polymorphic PTLDs (P-PTLD), monomorphic PTLDs (M-PTLD) and classical Hodgkin's Lymphoma PTLD (HL). These entities are felt to represent a disease continuum, with a precursor-product relationship, though they are morphologically and clinically distinct. However, this process remains poorly understood, and limited evidence exists to support this hypothesis. We report a series of nine cases extracted from a PTLD database, including both pediatric and adult solid organ transplant recipients, with

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Kalra, Amit, Cameron Roessner, Jennifer Jupp, Andrew Daly, and Jan Storek. "Limited Efficacy of Prompt Therapy of Posttransplant Lymphoproliferative Disorder (PTLD) with Rituximab." Blood 126, no. 23 (2015): 3114. http://dx.doi.org/10.1182/blood.v126.23.3114.3114.

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Abstract Introduction: Epstein-Barr virus (EBV)-induced posttransplant lymphoproliferative disorder (PTLD) incidence is particularly high when using graft versus host disease (GVHD) prophylaxis with rabbit antithymocyte globulin (ATG). Preemptive therapy with rituximab given when EBV DNAemia exceeds a threshold has been adopted by some centers. However, this exposes a large fraction of patients to rituximab, which is costly and toxic (neutropenia). Wagner et al suggested a high efficacy of prompt therapy (monitoring EBV DNAemia, having a high index of suspicion for PTLD in patients with high D

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Attygalle, Ayoma, Rajai Al-Jehani, Tim C. Diss, et al. "Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10." Blood 99, no. 2 (2002): 627–33. http://dx.doi.org/10.1182/blood.v99.2.627.

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Abstract Angioimmunoblastic T-cell lymphoma (AITL) is a systemic disease involving lymph nodes, spleen, and bone marrow. Although the histologic features have been well described, the diagnosis is often challenging, as there are no specific phenotypic or molecular markers available. This study shows that the neoplastic cells of AITL can be identified by aberrant CD10 expression. Archival material from 30 cases of AITL, 10 cases of peripheral T-cell lymphoma unspecified (PTL), and 10 cases of reactive lymphoid hyperplasia were reviewed. Single and double immunostaining for CD3, CD4, CD8, CD20,

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Rossi, Davide, Clara Deambrogi, Monia Lunghi, et al. "Aberrant Methylation of SHP-1 (SH2-Containing Phosphatases 1) and SOCS-1 (Suppressor of Cytokine Signalling 1) Genes in Immunodeficiency-Related Lymphomas." Blood 108, no. 11 (2006): 2386. http://dx.doi.org/10.1182/blood.v108.11.2386.2386.

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Abstract SHP-1 and SOCS-1 are members of a family of negative regulators of signaling that act downstream of cytokine receptors, receptor tyrosine kinases and receptor complexes of the immune and hemopoietic system. SHP-1 and SOCS-1 act through the inhibition of the JAK2/STAT pathway and their inactivation is considered to be a relevant mechanism in JAK2/STAT pathway induction. Several observations point to induction of the JAK/STAT pathway as an important mechanism of lymphomagenesis. Since DNA methylation is a mechanism of gene silencing involved in the pathogenesis of human cancers, includi

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Cook, David M., Karen M. Farizo, and Drusilla L. Burns. "Identification and Characterization of PtlC, an Essential Component of the Pertussis Toxin Secretion System." Infection and Immunity 67, no. 2 (1999): 754–59. http://dx.doi.org/10.1128/iai.67.2.754-759.1999.

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ABSTRACT PtlC is a member of a set of proteins necessary for the secretion of pertussis toxin (PT) from Bordetella pertussis. Using polyclonal antibodies specific for PtlC, we identified PtlC as a protein with an apparent molecular weight of 85,000 that localizes to the membrane fraction of bacterial cell extracts. We found that a mutant strain of B. pertussis that contains an in-frame deletion in ptlC is unable to secrete PT and that PT secretion is fully restored by expressing ptlC intrans, indicating that PtlC is essential for transport of PT across the bacterial membrane(s). PT secretion w

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Haider, Mobeen Zaka, Zarlakhta Zamani, Hasan Mehmood Mirza, et al. "A systematic review of post-transplant lymphoproliferative disorder after liver transplant." Journal of Clinical Oncology 39, no. 15_suppl (2021): e19045-e19045. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e19045.

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e19045 Background: Post-transplant lymphoproliferative disorder (PTLD) is a complication after liver transplantation. This study aims to explore the association of PTLD with the immunosuppression, types of PTLD, clinical presentation, and outcomes. Methods: Following the PRISMA guideline, we searched the literature on PubMed, Cochrane, Embase, and clinicaltrials.gov. 1741 articles were screened and 22 studies were included. Results: Data includes 22,235 total patients who underwent a liver transplant, and 449 (2.0%) patients who developed PTLD were studied. Of the 394 patients where gender was

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Muchtar, Eli, Liat Vidal, Ron Ram, et al. "Post-Transplant Lymphoproliferative Disorder in Lung Transplant Recipients – a Shift Lo Late Onset Disease." Blood 120, no. 21 (2012): 5075. http://dx.doi.org/10.1182/blood.v120.21.5075.5075.

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Abstract Abstract 5075 Background: Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication after solid organ transplantation. Most cases of PTLD arise within the first year from transplantation and are associated with EBV infection. However, there are increasing reports on a late onset form of PTLD. Methods: We reviewed all charts of patients undergoing either lung or heart-lung transplantation in a tertiary center in Israel between the years 1997 and 2012. PTLD was defined according to the WHO criteria. We analyzed baseline characteristics, clinical and pathologi

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Tosato, Giovanna, Julie Teruya-Feldstein, Joyce Setsuda, Sandra E. Pike, Karen D. Jones, and Elaine S. Jaffe. "Post-transplant lymphoproliferative disease (PTLD): lymphokine production and PTLD." Springer Seminars in Immunopathology 20, no. 3-4 (1998): 405–23. http://dx.doi.org/10.1007/bf00838052.

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Tosato, Giovanna, Julie Teruya-Feldstein, Joyce Setsuda, Sandra E. Pike, Karen D. Jones, and Elaine S. Jaffe. "Post-transplant lymphoproliferative disease (PTLD): lymphokine production and PTLD." Springer Seminars in Immunopathology 20, no. 3-4 (1998): 405–23. http://dx.doi.org/10.1007/s002810050044.

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Trendafilova, Natasha, Ivelina Georgieva, and George St Nikolov. "Platinum (II) Compounds With Antitumor Activity Studied by Molecular Mechanics." Metal-Based Drugs 5, no. 2 (1998): 91–102. http://dx.doi.org/10.1155/mbd.1998.91.

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A series of Pt(ll) complexes with antitumor properties: [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]PtL2 (meso-1-PtL2) and [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]PtL2, [2L=2Cl−,2I−,SO42−; halo = F (erythro-8-PtL2), halo = Cl (erythro-9-PtL2)] has been modelled by molecular mechanics (MM). The MM calculations were carried out for different isomers and ligand conformations meso-δ, meso-λ, d,l-δ, d,I-λ. The compounds with the lowest MM energies have the same geometries as those obtained by X-ray analysis. The calculated MMX energy orders: mes

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Mukhtar, Mariam S., and Stephen L. Wolman. "Post-transplant lymphoproliferative disorder as a cause of oesophageal ulceration and stricture: case report and literature review." BMJ Open Gastroenterology 8, no. 1 (2021): e000602. http://dx.doi.org/10.1136/bmjgast-2021-000602.

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Post-transplant lymphoproliferative disorder (PTLD) of the oesophagus is a rare complication of solid organ transplant that requires a high index of suspicion to diagnose. A literature review conducted on Ovid Medline database retrieved 24 articles, among which five previous cases of oesophageal PTLD were identified. Development of oesophageal strictures related to PTLD has not been reported in the literature. We report a case of oesophageal PTLD following lung transplant, presenting with extensive, circumferential ulceration in the oesophagus. PTLD was successfully treated with chemotherapy b

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Luan, Chih-Wei, Chih-Cheng Chen, Kam-Fai Lee, et al. "Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder." Healthcare 9, no. 2 (2021): 217. http://dx.doi.org/10.3390/healthcare9020217.

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(1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody

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Nakić Radoš, Sandra, Erin Burn, Susan Ayers, and Alexandra Sawyer. "Coping Styles Associated with Post-Traumatic Stress and Depression Symptoms Following Childbirth in Croatian Women." Psihologijske teme 27, no. 3 (2018): 543–59. http://dx.doi.org/10.31820/pt.27.3.10.

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Porođaj je normativni čin u životu žene i uglavnom se smatra pozitivnim događajem. Međutim, svaka treća žena doživi porođaj kao tjelesnu prijetnju za sebe i/ili za svoje novorođenče te 3 % žena nakon porođaja razvije posttraumatski stresni poremećaj (PTSP). Dosadašnja istraživanja upućuju na to da su slabe strategije suočavanja povezane s PTSP-om nakon porođaja, međutim, ta su se istraživanja uglavnom koristila jednodimenzionalnim mjerama strategija suočavanja. Drugim riječima, tek valja ispitati koje specifične dimenzije suočavanja pridonose PTSP-u nakon porođaja. Ciljevi su ovog istraživanja

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