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Journal articles on the topic "PU 1534"

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Stevenson, S. J. "Social and economic contributions to the pattern of ‘suicide’ in south-east England, 1530–1590." Continuity and Change 2, no. 2 (1987): 225–62. http://dx.doi.org/10.1017/s0268416000000588.

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Mon article précédent (Continuity and Change2 (1)) a évalué comment les vices des systèmes légaux et administratifs ont influencé le nombre de cas de suicide enregistrés en Angleterre entre 1530 et 1590. Le présent article se concentre sur les questions suivantes: la répartition des risques de suicide selon les âges, l'exploitation des tensions engendrées au sein des communautés confrontées à tout cas de suicide éventuel et la répartition des suicides parmi les régions supposées avoir une organisation sociale différente. En ce qui concerne l'âge et les tensions dan la communauté, on suggère que les risques de suicide auraient pu ètre les plus élevés parmi les jeunes, si I'on considère le fait que le plus grand nombre de noyades accidentelles a été également enregistré dans le groupe d'âge le plus jeune. La fréquente utilisation des verdicts de mort accidentelle aurait pu provenir à la fois de l'emploi courant des jeunes avec ou prés de l'eau et du peu d'intérêt de la communautéà prononcer des verdicts de suicide envers ceux qui ne possédaient ni terres ni biens à distribuer. II semble également probable que la mort violente sous tous ses aspects ait augmenté considérablement en période de pénurie et que bon nombre de suicides parmi les jeunes résultaient de leur expulsion des maisons où ils avaient été en service. En ce qui concerne la répartition géographique des suicides, aucune preuve concluante selon laquelle le nombre de suicides varierait sous différents régimes agraires n'a été découverte; et pourtant, il semble que le taux de suicide aurait pu être plus élevé dans les zones ayant la densité de population la plus basse. Certains thèmes abordés de façon fort peu concluante comprennent la fréquence des meurtres domestiques suivis de suicide, la géographic du suicide imitatif, les relatifs penchants vers le suicide des “intellectuels aliénes” de la fin du seizième siècle, ainsi que tout effet possible sur le taux de suicide causé par l'urbanisation ou la Réforme.
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HENDRY, Ross G., and Janice M. MARSHALL. "Vasoconstrictor products of cyclo-oxygenase activity limit acetylcholine-induced cutaneous vasodilatation in young men." Clinical Science 107, no. 3 (2004): 323–30. http://dx.doi.org/10.1042/cs20040077.

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In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded by the laser Doppler technique, evoked by a series of iontophoretic pulses of ACh were tested before and after oral aspirin (600 mg). Increases in RCF produced by successive pulses of ACh up to a mean change of 125.5±11.8 PU (perfusion units) were potentiated 30 min after aspirin (160.0±12.4 PU; P<0.05). By contrast, aspirin had no effect on increases in RCF evoked by iontophoretic application of the NO (nitric oxide) donor and endothelium-independent dilator sodium nitroprusside (mean increases in RCF were 73.8±9.8 PU before and 79.1±12.2 PU after aspirin). The ACh-evoked increases in RCF were also potentiated 3 h after oral administration of the antioxidant vitamin C (1000 mg; 139.1±15.4 PU before and 170.5±13.5 PU after vitamin C; P<0.05). We propose that, in healthy young men, cutaneous vasodilatation evoked in the finger by the endothelium-dependent dilator ACh is limited by constrictor products of the COX pathway, including PGH2 (prostaglandin H2), TXA2 (thromboxane A2) and/or superoxide anions. This effect of the COX products may be an early marker of the increased risk of cardiovascular disease in men compared with women.
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Bland, Joshua B., Jose R. Peralta, and William T. Tse. "Elevated EGR2 Expression Provides a Potential Link Between Cell Cycle Arrest and Induced Differentiation in Myeloid Progenitor Cells." Blood 124, no. 21 (2014): 2733. http://dx.doi.org/10.1182/blood.v124.21.2733.2733.

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Abstract Similar to many immature cell types, myeloid progenitor cells need to exit cell cycle to undergo terminal differentiation, but the mechanism linking the two is still unclear. Elucidating this mechanism could lead to the development of new differentiation therapies to treat myeloid leukemia. Recent studies have suggested that the processes regulating myeloid differentiation and cell cycle progression together constitute a positive feedback loop where each process reciprocally affects the other. To study the relationship between these processes, we examined early cellular and molecular events associated with induced differentiation of the HL60 human promyelocytic leukemia cells. We treated HL60 cells with 3 classical inducers of differentiation (vitamin D3 analog EB1089 (EB), all-trans retinoic acid (ATRA), and dimethyl sulfoxide (DMSO)), along with PD0332991 (PD), a selective cyclin D-dependent kinase 4/6 inhibitor that caused G1-phase-specific cell-cycle arrest. We evaluated differentiation of the treated cells by flow cytometric analysis of CD11b (integrin αM) and CD71 (transferrin receptor) expression. In untreated HL60 cells, a baseline subset of 3-5% of cells exhibits a differentiated, CD11b+CD71- phenotype. Exposure to the various inducers revealed a progressive increase in the percentage of CD11b+CD71- cells with time, such that by day 4 of treatment, it has increased to 50-90% in the treated samples, indicating that all 4 agents tested were effective in inducing myeloid differentiation. To understand how differentiation induced by each agent affects cell cycle progression, the cell cycle status of the induced cells were evaluated by a BrdU-incorporation assay after a 30-minute pulse of BrdU labeling. Uninduced cells exhibited a baseline cell cycle phase distribution of 64%-28%-8% (G1-S-G2/M phases). After 1 day of induction, EB-treated sample showed no changes in the distribution (58%-33%-9%), but ATRA, DMSO and PD-treated samples showed significant changes, with an increase of cell numbers in G1 phase and decrease in S phase (74%-18%-8%, 79%-13%-8%, and 93%-4%-3%, respectively). These results reveal that an early induction of G1 arrest was caused by treatment with ATRA, DMSO and PD, but not EB, and that the cell cycle arrest occurred before major changes in the myeloid phenotype were observed. To determine how the cell cycle perturbation relates to changes in the underlying genetic regulatory network, we examined by quantitative RT-PCR analysis the expression of several transcription factors associated with myeloid differentiation. PU.1 and CEBPA were found to be expressed at high levels but these levels did not change upon treatment with the inducing agents. Similarly, the expression levels of GFI1 and EGR1 did not change significantly with induction. In contrast, the expression level of EGR2 (Early Growth Response 2) was found to be low initially but became elevated upon treatment with 3 of the 4 inducers. EGR2 is a zinc finger transcription factor implicated in the control of a switch between pro- and anti-proliferation pathways. EGR2 has been shown to regulate the transition between differentiation states of Schwann cells, induction of anergic and regulatory T cells, growth and survival of osteoclasts, and proliferation and apoptosis of acute myeloid leukemia blasts. We found that EGR2 expression, after 1 day of treatment with ATRA, DMSO or PD, was increased by 5.2 ± 0.9, 7.6 ± 1.9, 5.8 ± 0.9 folds, respectively, whereas treatment with EB led to no significant change (1.5 ± 0.2 fold). We evaluated whether simultaneous treatment of the cells with 2 inducers would result in an additive effect. Treatment of HL60 cells with a combination of ATRA/DMSO, ATRA/PD, or DMSO/PD increased the percentage of CD11b+CD71- cells to 55%, 70% and 25% after just 1 day of treatment. In line with the enhanced phenotypic effect, the expression level of EGR2 was further elevated to 7.7 ± 1.4, 15.4 ± 3.5, and 11.3 ± 3.4 folds, respectively, when the cells were treated with the above inducer combinations, indicating a tight association between EGR2 expression and the phenotypic effect. In summary, our data suggest that elevated expression of EGR2 is an early event in the induction of myeloid differentiation in HL60 cells. Because of its known role in cell cycle regulation, EGR2 could function as a mechanistic link between cell cycle arrest and induced differentiation in myeloid progenitor cells. Disclosures No relevant conflicts of interest to declare.
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Zanini, Noelle C., Alana G. de Souza, Rennan FS Barbosa, Derval S. Rosa, and Daniella R. Mulinari. "Eco-friendly composites of polyurethane and sheath palm residues." Journal of Cellular Plastics, January 19, 2021, 0021955X2098715. http://dx.doi.org/10.1177/0021955x20987150.

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This work prepared eco-friendly biocomposites of polyurethane (PU) and sheath palm residues, using castor oil as a polyol. PU composites filled with natural fibers were prepared at different loading rates: 0 to 20 wt.%. Results indicated that the sheath palm was hydrogen-bonded to PU chains and increased the foams' density. Pore size decreased with an increase in fiber content, from 256 to 116 µm. The fiber's addition improved the ductility of PU foams (compressive modulus from 4.74 to 0.26 MPa) and the foams' crystallinity index (from 5.4 to 15.4%). Compared to pristine PU, the composites showed high hydrophobicity (reaching 123° of contact angle for PU-15%) and thermal stability (Tonset from 96 to 96.3°), and high density (from 41 to 60 kg.m−3), making the developed composites an excellent option for environmental applications, such as oil removal and contaminant adsorption.
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Burakov, Boris E., Maria A. Yagovkina, Maria V. Zamoryanskaya, et al. "Behavior of 238Pu-Doped Cubic Zirconia under Self-Irradiation." MRS Proceedings 807 (2003). http://dx.doi.org/10.1557/proc-807-213.

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ABSTRACTTo investigate the resistance of cubic zirconia to accelerated radiation damage, which simulates effects of long term storage, 238Pu-doped polycrystalline samples of cubic zirconia, (Zr,Gd,Pu)O2, were obtained and studied using X-ray diffraction analysis (XRD), electron probe microanalysis (EPMA), optical and scanning electron microscopy (SEM), and modified MCC-1 static leach test. The ceramic material was characterized by the following chemical composition (from EPMA in wt.% element): Zr = 50.2, Gd = 15.4, Pu = 12.2. This corresponds to the estimated formula, Zr0.79Gd0.14Pu0.07O1.99. The content of 238Pu estimated was approximately 9.9 wt.%. The XRD measurements were carried out after the following cumulative doses (in alpha decay/m3 × 1023): 3, 27, 62, 110, 134, 188, 234, and 277. Even after extremely high self-irradiation, cubic zirconia retained its crystalline structure. All XRD analyses showed no phases other than a cubic fluorite-type structure. The following results of normalized Pu mass loss (NL, in g/m2, without correction for ceramic porosity) were obtained from static leach tests (in deionized water at 90°C for 28 days) for 4 cumulative doses (in alpha decay/m3 × 1023):The results obtained confirm the high resistance of cubic zirconia to self-irradiation. This allows us to consider zirconia-based ceramic as the universal material that is suitable for actinide transmutation and geological disposal.
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Aloy, Albert S., T. I. Kolycheva, D. A. Knecht, and Y. Macheret. "Radiolytic Gas Generation in Chemically-bonded Iron Phosphate Ceramic Forms used for Immobilization of Plutonium Ash Residues." MRS Proceedings 556 (1999). http://dx.doi.org/10.1557/proc-556-1207.

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AbstractIron phosphate ceramic (IPC) samples were prepared with plutonium-238, and radiolytic gas generation was detennined for exposure times of up to 195 days. The specific activity of the synthesized IPC samples was 1.91 mCi/g. The composition of the generated gases was determined to contain mainly H, and lower amounts of O2, CO2 and CO. The molecular hydrogen G value (molecules of H2 per 100 eV absorbed dose) depended on the sample preparation methodology, ranging from 0.07 at 79 days for sample IPC-2 to 0.34 at 119 days for sample IPC-1. This difference could be due to different total amount (wt.%) of free water resulting in sample preparation. The leach rate data for radioactive and non-radioactive IPC samples obtained by the ANSI/ANS 16.1 procedure resulted in Leachability Indexes of 13.7 for Pu and 15.4 for Ce, above the NRC LLW acceptance minimum index of 6.
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Mehta, Ashish J., Pratibha C. Joshi, Xian Fan, et al. "Zinc Supplementation Restores PU.1 and Nrf2 Nuclear Binding in Alveolar Macrophages and Improves Redox Balance and Bacterial Clearance in the Lungs of Alcohol-Fed Rats." Alcoholism: Clinical and Experimental Research, March 2011, no. http://dx.doi.org/10.1111/j.1530-0277.2011.01488.x.

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Dissertations / Theses on the topic "PU 1534"

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Cho, Eun-Hee. "Die finanzielle Versorgung nach der Scheidung im deutschen und koreanischen Recht im Vergleich." Doctoral thesis, [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962678023.

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Kölmel, Dominik. "Das Regressrecht bei internationalen Lieferketten : unter besonderer Berücksichtigung des UN-Kaufrechts sowie der Richtlinie über den Verbrauchsgüterkauf /." Baden-Baden : Nomos, 2008. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016786633&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Book chapters on the topic "PU 1534"

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"half of pericarp lipids were unsaponifiable materials. Tip showed 86-91% NL, 2-5% GL, and 7-9% PL [14,56,152]. cap lipids had more TG, GL, and PL than pericarp lipids, Milled rice NSL had a lower NL fraction and a higher but were otherwise similar. GL fraction. The ratios for the NL:GL:PL for milled rice The compositions of NL, GL, and PL were computed are 82:8:10 by Choudhury and Juliano [56], 76:12:12 by (Table 41). The TG was over 90% of the NL in the germ Hirayama and Matsuda [55], and the range of (83-91): [137,138], about 60% in the endosperm NSL, but only (2-4):(1-3) by Azudin and Morrison [153]. 2.5% in endosperm SL. Over 90% of the NL was FFA in Azudin and Morrison [153] investigated NSL and SL in the SL. Weber [137] detected substantial quantities of CB milled rice of two waxy varieties (1.0-2.3% amylose) and and sulfolipids (tentative identification) in the GL of the 12 nonwaxy varieties (12.2-28.6% amylose). The TL germ and endosperm NSL. (NSL + SL) were extracted from rice flour and SL from pu-The major component in germ PL was PC, which was rified rice starch. The composition of the NSL could be ob-in good agreement between Tan and Morrison [138] and tained by the difference, as shown in Table 47. Weber [137]. However, the PL composition of the en-The major NL of NSL was TG, constituting 71-79% of dosperm NSL differed largely; Tan and Morrison [138] re-NSTL (Table 47) and 83-87% of NL [56,152]. The other ported 11.1% PC and 57.1% LPC, whereas Weber [137] important NL class was FFA, at 4-7% of the NSTL and reported 44.6% PC and 36.5% LPC plus an unknown. 13-17% of the NL for brown rice, bran, germ, and polish. The FA compositions were higher in levels of 18:0 and Unlike most other cereal NSL, the major GL of NSL of 18:3 for endosperm than germ (Table 42). For the LG-11 brown rice and its milling fractions were ASG and SG hybrid corn, germ lipids contained significantly more 18:2 (Table 47). Major PL classes were PC and PE. and less 16:0 and 18:3 than other parts of kernel [138]. For Choudhury and Juliano [56] reported that the distribu-the H-51 inbred corn, germ lipids contained less 18:3 than tion of brown rice NL was 14-18% in germ, 39-41% in other kernel parts but more 18:1 and 18:2 than pericarp and bran, 15-21% in polish, and 25-33% in milled rice tip cap. However, the 18:2 content was equal for both the (12-14% in subaleurone layer and 12-19% in the en-germ and the endosperm lipids [42]. The FA compositions dosperm). The distribution of the NSL of brown rice was in root and leaf lipids differ significantly from those of 43% in bran, 19% in germ, 15% in polish, and 21% in corn kernel or other kernel parts; corn leaf lipids contained milled rice; and for brown rice PL, 30% in bran, 14% each a much higher level of 18:3 and lower levels of 18:1 and in germ and polish, and 42% in milled rice [56,152]. 18:2 (Table 42). The TL (NSL + SL) compositions are different between Ohnishi et al. [150] investigated the positional distribu-waxy and nonwaxy rice varieties (Table 48). Azudin and tion of fatty acids in glycerolipid classes from corn total Morrison [153] reported that the two waxy rice (IR 29 and lipids (Table 43). Unsaturated fatty acids, 18:1 and 18:2, C441-4) starches prepared from the milled rice had very are located mainly in the 2-position of these glycerolipids. little amylose content (1.0-2.3%) and only traces of lipids However, PI showed relatively high 16:0 content at the 1-(16-19 mg per 100 g starch), which were probably SSL, position and 18:2 content at the 2-position. Fatty acid com-the NSL contaminants. The SSL were 100% FFA (Table positions of molecular species of glycerolipids were also 48). The TL in waxy rice were, therefore, NSL and they investigated by reverse-phase high-performance liquid evidently had suffered substantial lipolysis, judging by chromatography (Table 44). The main species generally high FFA values [153]. The nonwaxy starches contained contained 16:0-18:2, 18:1-18:2, and 18:2-18:2 for TG, 0.9-1.3% SL comprising, on average, 31.2% (29-45%) PC, PE, and PI. The main molecular species of DGDG FFA, 61.5% (48-67%) PL, and 3.2% GL [153], as shown contained 18:3-18:3, 18:1-18:2, 18:2-18:2, 18:2-18:3, in Table 48. and 18:1-18:3. Choudhury and Juliano [56] extracted SL from milled Vasanthan and Hoover [151] investigated the content rice after the NSL removal, using the one waxy variety (IR and composition of SSL and SL of purified corn starch 4445-63-1 with 2% amylose) and the two nonwaxy vari-(Table 45). The SSL contained mainly free S, SE, and LPL. eties (IR42 with 29% amylose and IR480-5-9 with 24% The SL contained mainly FFA and LPL. Fatty acid compo-amylose). The SL composition of the milled rice of the sition indicated that 16:0 and 18:2 were the principal fatty waxy variety contained 41% PL and 7% GL, whereas the acids of SL and SSL (Table 46). waxy starch by Azudin and Morrison [153] contained no GL and PL (Table 48). The SL compositions of waxy rice and nonwaxy rice (both milled and brown) were different Rice hull lipid composition differs significantly from that in [56] but not to the extent shown by Azudin and Morrison brown rice and its fractions (Table 47). Silicic acid fraction-[153]. ation of NSL from brown rice, bran, germ, and polish The FA compositions of NSL and SL classes in the three." In Handbook of Cereal Science and Technology, Revised and Expanded. CRC Press, 2000. http://dx.doi.org/10.1201/9781420027228-46.

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Conference papers on the topic "PU 1534"

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Jhaveri, K., M. Dunphy, R. Wang, et al. "Abstract P6-20-03: Tumor epichaperome expression using124I PU-H71 PET (PU-PET) as a biomarker of response for PU-H71 plus nab-paclitaxel in HER2 negative (HER2-) metastatic breast cancer (MBC)." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p6-20-03.

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Gu, Xiaorong, Reda Mahfouz, Ji Zhang, et al. "Abstract 2872: Cytoplasmic localization of PU.1 with mutated NPM1 causes myeloid differentiation arrest." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2872.

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Mark, Frank E., and Axel Kamprath. "Recycling & amp; Recovery Options for PU Seating Material: A Joint Study of ISOPA /Euro-Moulders." In Total Life Cycle Conference and Exposition. SAE International, 2000. http://dx.doi.org/10.4271/2000-01-1514.

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Thies, Katie, David A. Taffany, Haritha Mathsyaraja, et al. "Abstract C30: The CSF1-PU.1 pathway in tumor associated macrophages promotes breast cancer growth and progression." In Abstracts: AACR Special Conference: The Function of Tumor Microenvironment in Cancer Progression; January 7-10, 2016; San Diego, CA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.tme16-c30.

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Ambati, Srikanth R., Eloisi Caldas Lopes, Ullas Mony, et al. "Abstract 2752: Novel inhibitor of HSP90- PU-H71 exhibits significant activity in Ewing sarcoma pre-clinical models." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2752.

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Lopes, Eloisi Caldas, Paula Bos, Hector Peinado, et al. "Abstract 5766: The Hsp90 inhibitor PU-H71 is a potent suppressor of metastasis in triple-negative breast cancer models." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5766.

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Li, Yajun, Bo Li, Qiang Li, Lixia Zhang, and Ping Li. "Abstract 2088: PU.1 enrichment to intronic enhancers is required for meis1 gene expression in both hematopoiesis and leukemogenesis." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2088.

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Solomon, Lauren A., Stephen K. h. Li, Jan Piskorz, Li S. Xu, and Rodney P. DeKoter. "Abstract 2098: Genome-wide comparison of PU.1 and Spi-B binding sites in a mouse B lymphoma cell line." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2098.

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Tschan, Mario P., Aladin Haimovici, Daniel Brigger, Anna M. Schläfli, Deborah Shan, and Martin F. Fey. "Abstract 2348: Low PU.1 expression not only attenuates neutrophil differentiation of AML cells but also increases resistance to cytotoxic therapies." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2348.

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Rojas Bilbao, Erica A., Elisa D. Bal de Kier Joffe, Marta E. Zerga, Lydia I. Puricelli, and Stella Maris N. Ranuncolo. "Abstract 3550: Expression of Oct-2, OCA-B, BCL6, PU.1 and IRF8 predicts prognosis in Diffuse Large B Cell Lymphoma patients." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3550.

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