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Journal articles on the topic 'Pulsatile Release'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Hakim, T. S. "Flow-induced release of EDRF in the pulmonary vasculature: site of release and action." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 1 (1994): H363—H369. http://dx.doi.org/10.1152/ajpheart.1994.267.1.h363.

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Pulsatile flow is thought to lower pulmonary vascular resistance by passive recruitment of capillaries and by active vasodilation. This study was undertaken to investigate the role of endothelium-derived relaxing factor (EDRF) during pulsatile flow in isolated canine left lower lobes pretreated with indomethacin. The lobes were perfused in situ with autologous blood (approximately 500 ml/min) using a nonpulsatile pump (Masterflex) or a pulsatile pump (Harvard). With the occlusion techniques, vascular resistance was partitioned into four segments: arterial (Ra), small arterial (R'a), small veno

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Hussein, Mayssam, and Israa Nathir. "Pulsatile Drug Delivery System Utilizing Innovative Technology." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 601–6. http://dx.doi.org/10.53350/pjmhs22166601.

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Drugs might be released immediately or over time. Pulsatile medication release systems, on the other hand, have been increasing in popularity in recent years. Many medications or therapies could benefit from pulsatile drug release, in which the drug is released rapidly after a predetermined lag time. Pulsatile release systems come in pairs: multi and separate pulse. Rupturable dose forms are a prominent type of single-pulse device. Other methods have a drug-containing centre covered by both a swelling surface and a semi - permeable barrier polymer layer or membrane that is semipermeable but no

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3

Kundan Rajendra Mahajan, Ashish Prakash Gorle, and Vijay Sanjay Khalane. "Overview on pulsatile drug delivery system." International Journal of Science and Research Archive 5, no. 2 (2022): 110–18. http://dx.doi.org/10.30574/ijsra.2022.5.2.0067.

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Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal

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Gandhi, Swapnil, Matthew D. Gosse, Yasuhiro Nishii, and Eric Nuxoll. "Barrier-Mediated Pulsatile Release." Journal of Membrane Science 495 (December 2015): 351–60. http://dx.doi.org/10.1016/j.memsci.2015.07.066.

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Nishii, Yasuhiro, Swapnil Gandhi, and Eric Nuxoll. "Glucose-powered pulsatile release." Chemical Engineering Research and Design 106 (February 2016): 298–307. http://dx.doi.org/10.1016/j.cherd.2015.11.024.

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6

Sungthongjeen, Srisagul, and Satit Puttipipatkhachorn. "Comparison between Ethylcellulose Aqueous Colloidal Dispersion and Ethylcellulose Ethanolic Solution as Rupturable Coating Materials for Pulsatile Release Tablets." Advanced Materials Research 506 (April 2012): 489–92. http://dx.doi.org/10.4028/www.scientific.net/amr.506.489.

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Pulsatile release dosage forms which time of drug release can be determined have shown advantages for various drugs such as chronopharmacological drugs and drugs with high first pass metabolism. The pulsatile release tablets consisting of drug-containing cores coated with inner swelling layer containing a superdisintegrant (croscarmellose sodium (Ac-Di-Sol®)) and outer rupturable layer (ethylcellulose (EC)) were previously developed. In this study, two different types of EC coating membrane, EC ethanolic solution (ECS) versus EC aqueous colloidal dispersion (ECD), were compared. Propranolol HC

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Koshta, Ashok, and Neelesh Malviya. "Formulation and Evaluation of Floating-pulsating Drug Delivery System containing Fixed-dose Combination for Chronotherapy of Hypertension." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1725–32. http://dx.doi.org/10.25258/ijddt.12.4.39.

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This project aims to build a floating, pulsatile hypertension therapy. This work examined the 3-factor, 2-level box-behnken design and optimization technique for the floating pulsatile tablet. The quantity of polyox WSR N12K and polyox WSR205 was chosen to be the independent variable. Drug release, lag time, and swelling index are chosen to function in terms of dependent variables. ANOVA was intended to assess the data statistically, and p-value of 0.05 was regarded to have statistical significance. The tablet containing bisoprolol fumarate (BF) and hydrochlorothiazide (HCTZ) was chosen for pr

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Jiabi, Ouyang, Wang Xingli, Yang Mohui, Tan Yani, Zhang Zhen, and Li Sha. "Preparation and Drug Release Mechanism of Time Controlled Explosive Pulsatile Tablets with Ethylcellulose Coating." Journal of Pharmaceutical and Biomedical Sciences 10, no. 04 (2020): 81–90. https://doi.org/10.5281/zenodo.3903240.

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<em><strong>Core tip:</strong></em> The development of pharmacology in the decade revealed the biological rhythm of the occurrence and development of certain diseases, usually the circadian rhythm. Therefore, chronopharmacological drug delivery is of great significance in the prevention and treatment of diseases having onset rhythm inconvenient to take drug. An easy-to-prepared, time-controlled explosive metoprolol tartaric pulsatile tablet was developed in order to provide patients with timed therapy of effective blood drug concentration at the optimal time. The formulation and process were o

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Cohen, Smadar, and Robert Langer. "Pulsatile Release from Microencapsulated Liposomes." Journal of Liposome Research 4, no. 1 (1994): 349–60. http://dx.doi.org/10.3109/08982109409037049.

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10

Medlicott, Natalie J., and Ian G. Tucker. "Pulsatile release from subcutaneous implants." Advanced Drug Delivery Reviews 38, no. 2 (1999): 139–49. http://dx.doi.org/10.1016/s0169-409x(99)00013-7.

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11

Gandhi, Swapnil, and Eric Nuxoll. "Non-delaminating pulsatile release composites." Chemical Engineering Science 141 (February 2016): 133–42. http://dx.doi.org/10.1016/j.ces.2015.10.037.

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12

Banu, Sakhila K., JeHoon Lee, Sam D. Stephen, Thamizh K. Nithy та Joe A. Arosh. "Interferon Tau Regulates PGF2α Release from the Ovine Endometrial Epithelial Cells via Activation of Novel JAK/EGFR/ERK/EGR-1 Pathways". Molecular Endocrinology 24, № 12 (2010): 2315–30. http://dx.doi.org/10.1210/me.2010-0205.

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Abstract In ruminants, pulsatile release of prostaglandin F2α (PGF2α) from the endometrium is transported to the ovary and induces luteolysis thereby allowing new estrous cycle. Interferon tau (IFNT), a type 1 IFN secreted by the trophoblast cells of the developing conceptus, acts on endometrial luminal epithelial (LE) cells and inhibits pulsatile release of PGF2α and establishes pregnancy. One of the unknown mechanisms is that endometrial pulsatile release of PGF2α is inhibited whereas basal release of PGF2α is increased in pregnant compared with nonpregnant sheep. We have recently found that

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13

Jenkin, G. "Interaction between oxytocin and prostaglandin F2 alpha during luteal regression and early pregnancy in sheep." Reproduction, Fertility and Development 4, no. 3 (1992): 321. http://dx.doi.org/10.1071/rd9920321.

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The pulsatile release of oxytocin from the corpus luteum in the sheep is responsible for the pulsatile release of prostaglandin F2 alpha (PGF2 alpha) from the uterus at luteolysis. It has been proposed that PGF2 alpha also reinforces this process by stimulating the release of oxytocin from the corpus luteum. It is, however, unlikely that PGF2 alpha is the major stimulus for oxytocin release at this time. Although the stimulus for the pulsatile release of oxytocin from the corpus luteum appears to reach the ovary from the peripheral circulation, the nature of the stimulus is unknown. Pulses of

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Shelke Amruta P, Wagh Priti A, Nikam Sakshi M, and Bhosale Jaydeep J. "Pulsatile drug delivery system: A review." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 457–66. https://doi.org/10.30574/wjbphs.2025.21.2.0187.

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Pulsatile Drug Delivery Systems (PDDS) are increasingly recognized for their ability to deliver drugs at specific times, tailored to the pathophysiological needs of a disease. This approach enhances therapeutic efficacy and patient compliance. The core concept of PDDS involves a defined lag-time before a rapid drug release, which can be particularly beneficial for treatments requiring synchronization with the body’s natural circadian rhythms. By aligning peak plasma concentrations with these biological cycles, PDDS can improve both the safety and effectiveness of drugs over a 24-hour period. T

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Vani, Chiluvuru, and K. Srinivas Reddy. "PULSATILE DRUG DELIVERY SYSTEM-A TECHNIQUE OF DELIVERING DRUG IN ACCORDANCE WITH BIOLOGICAL CLOCK - A REVIEW." International Journal of Advanced Research 9, no. 4 (2021): 101–24. http://dx.doi.org/10.21474/ijar01/12813.

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Over last 30 years pulsatile drug delivery system has achieved a lot of importance in drug delivery technology. And the reason why this pulsatile drug delivery is gaining importance is because of its strategy of delivering drug molecule at right place, right time. There are certain diseases which are controlled by biological clock of our body and follow circadian rhythms like congestive heart failure, asthma, rheumatoid arthritis ,osteoarthritis, inflammatory disorders and other hormonal disorders, for this type of diseases conventional solid dosage forms like immediate release tablets or modi

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16

Mohui, Yang, Wang Xingli, Ouyang Jiabi, Zhang Zhen, Tan Yani, and Li Sha. "Drug Release and Pharmacokinetics Behavior of a Simple Ethylcellulose Coating Pulsatile Tablet of Time-Controlled Explosive System." Journal of Pharmaceutical and Biomedical Sciences 10, no. 03 (2020): 57–64. https://doi.org/10.5281/zenodo.3903310.

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<em><strong>Core tip:</strong></em> The time rhythm of the human body is associated with the occurrence and development of many diseases. Kinds of diseases of particular onset biorhythm provided the room for the development of chronopharmacological drug delivery systems. Metoprolol tartrate (MT), a medicine commonly used for treatment of cardiovascular diseases in clinic, was selected as model drug to develop a time-controlled explosive pulsatile tablet. The prepared MT pulsatile tablets showed a drug release lag time of 7.10 h <em>in vitro</em> perfectly consistent with the absorption lag tim

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Clarke, Iain, Lloyd Moore, and Johannes Veldhuis. "Intensive Direct Cavernous Sinus Sampling Identifies High-Frequency, Nearly Random Patterns of FSH Secretion in Ovariectomized Ewes: Combined Appraisal by RIA and Bioassay." Endocrinology 143, no. 1 (2002): 117–29. http://dx.doi.org/10.1210/endo.143.1.8644.

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Abstract Analyses of FSH secretion suggest pulsatile, nonpulsatile, or compositely pulsatile and nonpulsatile release modes. This may reflect the reduced signal-to-noise ratio inherent in FSH pulse estimation procedures and/or immunological-biological assay inconsistencies. To address these issues, we sampled cavernous sinus and jugular venous blood concomitantly from ovariectomized sheep at either 5-min or 1-min intervals. Samples from the former were assayed by RIA, and those from the latter by RIA and bioassay. Waveform-independent peak detection revealed FSH pulses occurring at high freque

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18

Steyn, F. J., Y. Wan, J. Clarkson, J. D. Veldhuis, A. E. Herbison, and C. Chen. "Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice." Endocrinology 154, no. 12 (2013): 4939–45. http://dx.doi.org/10.1210/en.2013-1502.

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Current methodology to monitor pulsatile LH release in mice is limited by inadequate assay sensitivity, resulting in the need for collection of large blood volumes. Thus, assessment of pulsatile LH secretion in mice remains highly challenging, and observations are limited to adult mice. To address this, we developed a highly sensitive ELISA for assessment of mouse LH concentrations in small fractions of whole blood. We demonstrate that this assay is capable of reliably detecting LH down to a theoretical limit of 0.117 ng/mL in a 2-μL fraction of whole blood. Using an established frequent blood

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P, Mahalakshmi, Suriyaprakash T N K, and S. Lakshmana Prabu. "Chronomodulated Delivery of Pantoprazole for Nocturnal Hyperacidity." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3038–44. http://dx.doi.org/10.37285/ijpsn.2015.8.4.7.

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The objective of this work was to design and evaluate an oral site-specific, pulsatile drug delivery system containing Pantoprazole sodium which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal hyperacidity. Five different composition of Core tablets were prepared by direct compression technique. Based on the release studies of core tablets, nine different compositions of press coated tablets were prepared and analyzed. The press coated tablet further coated by using five different proportions of Eudragit

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Raj, Behin Sundara, I. S. R. Punitha, and M. J. Gifty. "Formulation and Evaluation of Floating Pulsatile Drug Delivery System of Ibuprofen and Ranitidine Combination." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3009–17. http://dx.doi.org/10.37285/ijpsn.2015.8.4.3.

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Since rheumatoid arthritis patients experience severe pain, inflammation, and joint stiffness in the early morning hours a pulsatile drug delivery system of a suitable anti-inflammatory drug that is administered at bedtime but release the drug in the early morning would be a promising system. The objective of this work was to develop a pulsatile release tablet containing a combination of ibuprofen and ranitidine HCl from which ibuprofen gets released after a lag time of 6-7 hours. The methodology involves; analytical method development for simultaneous estimation of combination drugs, developm

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Benlot, Caroline, Laurence Lévy, Pierre Fontanaud, Annick Roche, Philippe Rouannet, and Dominique Joubert. "Somatostatin and Growth Hormone-Releasing Hormone in Normal and Tumoral Human Breast Tissue: Endogenous Content, in Vitro Pulsatile Release, and Regulation." Journal of Clinical Endocrinology & Metabolism 82, no. 2 (1997): 690–96. http://dx.doi.org/10.1210/jcem.82.2.3754.

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Abstract Endogenous production of SRIH and GHRH was analyzed in human breast tissue. SRIH precursor (pro-SRIH) was identified after Sephadex G-50 filtration of acetic acid extracts of normal and tumoral human breast samples. SRIH-(1–14) or -(1–28) could not be detected in breast tissue, whereas the immunoreactive SRIH released in vitro was characterized as SRIH-(1–28). Endogenous production of GHRH was assessed by identification of GHRH messenger ribonucleic acid by PCR followed by sequencing of the amplified complementary DNA and by high performance liquid chromatographic characterization of

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Kikuchi, Akihiko, and Teruo Okano. "Pulsatile drug release control using hydrogels." Advanced Drug Delivery Reviews 54, no. 1 (2002): 53–77. http://dx.doi.org/10.1016/s0169-409x(01)00243-5.

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Maroni, Alessandra, Lucia Zema, Giulia Loreti, Luca Palugan, and Andrea Gazzaniga. "Film coatings for oral pulsatile release." International Journal of Pharmaceutics 457, no. 2 (2013): 362–71. http://dx.doi.org/10.1016/j.ijpharm.2013.03.010.

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Bergsten, Peter. "Pathophysiology of impaired pulsatile insulin release." Diabetes/Metabolism Research and Reviews 16, no. 3 (2000): 179–91. http://dx.doi.org/10.1002/1520-7560(200005/06)16:3<179::aid-dmrr115>3.0.co;2-c.

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Cagampang, F. R. A., K. I. Maeda, H. Tsukamura, S. Ohkura, and K. Ôta. "Involvement of ovarian steroids and endogenous opioids in the fasting-induced suppression of pulsatile LH release in ovariectomized rats." Journal of Endocrinology 129, no. 3 (1991): 321–28. http://dx.doi.org/10.1677/joe.0.1290321.

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ABSTRACT The participation of the ovarian steroids and opioid peptides in the suppression of pulsatile LH release during acute fasting was examined in rats. Ovariectomized rats bearing silicone elastomer implants of oestradiol and/or progesterone were fasted for 48 h and subsequently blood samples were taken every 6 min for 3 h. Pulsatile LH release was suppressed after 48 h of fasting in the ovariectomized rats implanted with oestradiol but not in the oil-implanted controls. This suppression was enhanced after the administration of progesterone together with oestradiol. In a second experiment

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james, Apollo, Jasmina khanam, Mohanraj Palanisamy, and Arun Radhakrishnan. "Preparation and Bio Pharmaceutical Evaluation of Chrono Pharmaceutical Drug Delivery System of Atenolol." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4761–69. http://dx.doi.org/10.55522/jmpas.v11i2.3310.

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A time-adjustable pulsatile release system containing atenolol as an active pharmaceutical agent was developed for bedtime dosage administration and release of medicine in the early morning to manage elevated blood pressure. The system contained an immediate release (IR) core, a sustained-release (SR) plug, and a mucoadhesive cup layer and it was designed by the cup and core technique. The immediate-release layer was composed of atenolol, croscarmellose sodium, microcrystalline cellulose (MCC), sorbitol, talc, and magnesium stearate. The SR plug was composed of hydroxyl propyl methylcellulose

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Albadri, Ahmed A., Mustafa R. Abdulbaqi, and Yasir Q. Almajidi. "Recent Trends in Chronopharmaceutics, Pulsatile Drug Delivery System." Al Mustansiriyah Journal of Pharmaceutical Sciences 19, no. 4 (2019): 41–49. http://dx.doi.org/10.32947/ajps.v19i4.631.

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Pulsatile Drug Delivery Systems (PDDS) are getting considerable interest in delivering a drug at the correct position, at the correct time, and in the correct quantity, thus offering temporal, spatial, and intelligent delivery with improving patient compliance. These systems are  intended to meet body's biological rhythm. Here, the delivery of drugs is assisted by the rhythm of disease. The main reason for the using pulsatile drug release is when the continuous drug release is not required. A PDDS must be designed in such a way that after the lag time a complete and fast release of

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Krsmanovic, Lazar Z., Antonio J. Martinez-Fuentes, Krishan K. Arora, et al. "Autocrine Regulation of Gonadotropin-Releasing Hormone Secretion in Cultured Hypothalamic Neurons." Endocrinology 140, no. 3 (1999): 1423–31. http://dx.doi.org/10.1210/endo.140.3.6588.

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Abstract Episodic hormone secretion is a characteristic feature of the hypothalamo-pituitary-gonadal system, in which the profile of gonadotropin release from pituitary gonadotrophs reflects the pulsatile secretory activity of GnRH-producing neurons in the hypothalamus. Pulsatile release of GnRH is also evident in vitro during perifusion of immortalized GnRH neurons (GT1–7 cells) and cultured fetal hypothalamic cells, which continue to produce bioactive GnRH for up to 2 months. Such cultures, as well as hypothalamic tissue from adult rats, express GnRH receptors as evidenced by the presence of

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Nath, Bipul, and Santimoni Saikia. "Characterization and Screening of a Novel Multiparticulate Pulsatile Delivery of Aceclofenac." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 5 (2016): 3494–501. http://dx.doi.org/10.37285/ijpsn.2016.9.5.7.

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In the present investigation, sodium alginate based multiparticulate system overcoated with time and pH dependent polymer was studied in the form of oral pulsatile system to achieve pulsatile with sustained release of aceclofenac for chronotherapy of rheumatoid arthritis seven batches of micro beads with varying concentration of sodium alginate (2-5 %) were prepared by ionotropic-gelation method using CaCl2 as cross-linking agent. The prepared Ca-alginate beads were coated with 5% Eudragit L100 and filled into pulsatile capsule with varying proportion of plugging materials. Drug loaded microbe

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James, Apollo, Mohanraj Palanisamy, Jasmina Khanam, Mohanraj Palanisamy, and Arun Radhakrishnan. "Prepartion And Bio Pharmaceutical Evaluation Of Chronopharmaceutical Drug Delivery System Of Metoprolol." Journal of University of Shanghai for Science and Technology 23, no. 09 (2021): 1052–68. http://dx.doi.org/10.51201/jusst/21/09643.

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The basic purpose of constructing drug delivery systems is to design when and where the drug will be released. The episode of many biological events is really important for such knowledge. Metoprolol pulsatile drug delivery system was developed for this purpose, which can release the drug when blood pressure needs to be modulated in the early morning. The Cup and core techniques were used to build this system, which included immediate release (IR), sustained-release (SR), and a polycaprolactone plug layer. The formulation of the ingredients was facilitated by various preformulation studies. Th

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Greenspan, S. L., A. Klibanski, J. W. Rowe, and D. Elahi. "Age alters pulsatile prolactin release: influence of dopaminergic inhibition." American Journal of Physiology-Endocrinology and Metabolism 258, no. 5 (1990): E799—E804. http://dx.doi.org/10.1152/ajpendo.1990.258.5.e799.

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To determine the effect of age on pulsatile prolactin secretion, we examined prolactin pulse characteristics by cluster analysis in healthy young and old male subjects during the day and night. Pulsatile prolactin secretion was identified in all subjects during the day and night, and prolactin pulse frequency remains stable with age. Younger subjects had a significantly higher prolactin pulse amplitude, area, and peak interval during the night compared with older subjects. In contrast, daytime prolactin pulse characteristics were similar in young and old subjects. Because the major neuroregula

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PRIYA, PITTU VISHNU, JVC Sharma, G. Archana, Hasan Arshi, M. Arjun Singh, and V. Nikhila. "THE Formulation and In-vitro evaluation of press coated tablets of pravastatin for pulsatile drug delivery." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 437–44. http://dx.doi.org/10.22270/jddt.v9i2-s.2727.

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The aim of present study is to formulate and evaluate Pravastatin pulsatile drug delivery system by press coated method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 hrs. The basic design of the system consists of a rapid release core and controlled release coat. Core blend was evaluated for flow properties, hardness, thickness, friability and invitro drug release. Invitro drug release studies of press coated tablets for various formulations i.e., P1F6-P5F6 was conducted. From the results obtained by executed trails P5F6 of coate

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Terasawa, Ei, and David L. Fernandez. "Neurobiological Mechanisms of the Onset of Puberty in Primates*." Endocrine Reviews 22, no. 1 (2001): 111–51. http://dx.doi.org/10.1210/edrv.22.1.0418.

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Abstract An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the LHRH neurosecretory system is already active during the neonatal period but subsequently enters a dormant state in the juvenile/prepubertal period. Neither gonadal steroid hormones nor the absence of facilitatory neuronal inputs to LHRH neurons is responsible for the low levels of LHRH release before the onset of puberty in primates. Recent studies suggest that during the prepubertal period an inhibit

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Dinkar, Renu, Govind Mohan, and Kumud Upadhyaya. "Development and evaluation of nifidipine loaded tablet formulation for colon drug delivery." Indian Journal of Pharmaceutical and Biological Research 1, no. 04 (2013): 64–70. http://dx.doi.org/10.30750/ijpbr.1.4.12.

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Pulsatile release profile is characterized by a lag time followed by rapid and complete drug release. Pulsatile drug delivery systems are classified into time-controlled and site-specific delivery systems. The lag time is taken as the time of less than 10% drug release. The objective of present study was to develop a pulsatile compression coated tablet. The system was developed into two steps i.e. firstly core tablet was prepared containing Nifidipine; secondly core tablet was coated with polymer blend of ethyl cellulose (water insoluble polymer) and Eudragit L 100 (Enteric polymer). From the

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Radke, Rahul S., Bharat B. Dhore, Ramesh R. Pagore, and Kailash R. Biyani. "Formulation, Development and Evaluation of Pulsatile Tablets of Etoricoxib." Journal of Drug Delivery and Therapeutics 14, no. 11 (2024): 89–94. http://dx.doi.org/10.22270/jddt.v14i11.6890.

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Aim: This research aimed to develop a pulsatile drug delivery system (PDDS) for etoricoxib, selective COX-2 inhibitor analgesic, to address the limitations of conventional formulations by releasing the drug at specific intervals aligned with the circadian rhythm of pain. Method: Core tablets containing Etoricoxib were prepared by direct compression with varied concentrations of croscarmellose sodium as a superdisintegrant. The optimized core tablets were coated using hydrophilic (HPMC K4M) and hydrophobic (ethyl cellulose) polymers in different ratios to create press-coated pulsatile tablets w

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Schmitt, C. P., F. Schaefer, D. Huber, et al. "1,25(OH)2-vitamin D3 reduces spontaneous and hypocalcemia-stimulated pulsatile component of parathyroid hormone secretion." Journal of the American Society of Nephrology 9, no. 1 (1998): 54–62. http://dx.doi.org/10.1681/asn.v9154.

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To investigate the effects of 1,25(OH)2-vitamin D3 (1,25(OH)2D3) on pulsatile parathyroid hormone (PTH) release, minute-to-minute intact PTH secretion was examined in nine healthy adults under baseline conditions and during hypocalcemia (sodium citrate clamp) before and after 5 d of oral 1,25(OH)2D3 treatment (1 microgram/d). In addition, acute effects of 1,25(OH)2D3 were examined by a single intravenous bolus of 2 micrograms of 1,25(OH)2D3. Pulsatile and tonic PTH secretion rates were calculated by the multiparameter deconvolution technique. During baseline, 68% of circulating PTH was attribu

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Gangadhar, B., B. Sai Bhanu Sree, PV Swamy, and M. Aruna Devi. "PULSATILE DRUG DELIVERY SYSTEM: A REVIEW." International Journal of Research in Ayurveda and Pharmacy 13, no. 6 (2022): 124–30. http://dx.doi.org/10.7897/2277-4343.1306171.

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Pulsatile Drug Delivery Systems (PDDS) are gaining a lot of interest as the delivery of the drug will be at the right site and at the right time, and the amount of drug that is reaching the site of action will also be so accurate, and therefore it generally improves the patient compliance. These followed a sigmoidal drug release profile and were characterized by a time of no drug release followed by a rapid and complete drug release. This article focuses on the various types of methodologies involved for the existing system and different marketed technologies, including PulsincapTM, OROS, DIFF

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Obonsawin, M. C., S. H. Shin, and J. Arrowsmith. "Surgery depresses pulsatile growth hormone release in rats for up to 2 days." Acta Endocrinologica 110, no. 1 (1985): 42–45. http://dx.doi.org/10.1530/acta.0.1100042.

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Abstract. In order to study the pulsatile release of rat growth hormone in a stress-free environment, many investigators obtain sequential blood samples from individual rats bearing an indwelling, right atrial cannula. There has been little systematic study of the stressful effects of the cannulation procedure on the pulsatile release of rat growth hormone. We examined the acute and chronic effects of right atrial cannulation on growth hormone release in male rats by monitoring plasma growth hormone concentration at every 2 min. Right atrial cannulation was performed under ether anaesthesia. B

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J. Singhavi, Dilesh. "DUAL RELEASE CHRONOTHERAPEUTIC SYSTEM OF POORLY WATER SOLUBLE ANTIHYPERTENSIVE DRUG CARVEDILOL: DESIGN, DEVELOPMENT AND IN VITRO CHARACTERIZATION." Indian Drugs 60, no. 04 (2023): 24–30. http://dx.doi.org/10.53879/id.60.04.12851.

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The current research investigation’s goal was to design a core-in-cup type pulsatile system of an antihypertensive drug (carvedilol phosphate) to reduce the evening and early-morning symptoms of hypertension. An inclusion complex of this drug was prepared with hydroxyl propyl beta cyclodextrin to increase carvedilol solubility. Using direct compression method, various batches of core tablets were formulated using Croscarmellose sodium as a superdisintegrant. Core tablets of the optimized formulation were press coated with backing layer and release-retarding plug layer. An in vitro release rese

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Keraliya, Rajesh A., and Madhabhai M. Patel. "Effect of viscosity of hydrophilic coating polymer on lag time of atenolol pulsatile press coated tablets." JOURNAL OF PHARMACEUTICAL CHEMISTRY 1, no. 1 (2014): 15. http://dx.doi.org/10.14805/jphchem.2014.art2.

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A method for the development of press coated tablet of atenolol for pulsatile delivery was investigated for chronotherapy of hypertension. Effect of viscosity of Hydroxypropylcellulose (HPC) on pulsatile release of atenlol was studied by press coating atenolol core tablet using different viscosity grade HPC and varying coat weight. L-HPC, M-HPC and H-HPC viscosity garde with 75, 100 and 150 mg coat weight were press coated over atenolol core tablets to delay release of atenolol. The batches, HP1-HP9, exhibited an increase in lag time in response to increase in viscosity and coat weight. Two of

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Nakano, Toshihide, Ryuji Tominaga, Ichiro Nagano, Hayato Okabe, and Hisataka Yasui. "Pulsatile flow enhances endothelium-derived nitric oxide release in the peripheral vasculature." American Journal of Physiology-Heart and Circulatory Physiology 278, no. 4 (2000): H1098—H1104. http://dx.doi.org/10.1152/ajpheart.2000.278.4.h1098.

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The effects of pulsatility in blood flow on endothelium-derived nitric oxide (EDNO) release in the peripheral vasculature were investigated. The basal and flow-stimulated EDNO release were compared between pulsatile and nonpulsatile systemic flows before and after the administration of NO synthase inhibitor NG-monomethyl-l-arginine (l-NMMA). Peripheral vascular resistance (PVR) was significantly lower in pulsatile flow than in nonpulsatile flow, but this difference disappeared after l-NMMA. The percent increase in PVR by l-NMMA was significantly larger in pulsatile flow. In reactive hyperemia

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Dhiraj S. Bhusewad, Sandip A. Wathore, Gunesh N. Dhembre, et al. "Development and evaluation of pulsatile drug delivery system of Telmisartan." World Journal of Biology Pharmacy and Health Sciences 20, no. 2 (2024): 403–12. http://dx.doi.org/10.30574/wjbphs.2024.20.2.0883.

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The aim of the present study was the formulation of pulsatile tablets of Telmisartan by press coating technique that could release the drug time controlled manner. The core tablets and press coated pulsatile tablet of Telmisartan was prepared by direct compression technique. The core tablets were formulated using super disintegrating agent cross carmilose sodium and pulsatile tablets were by using polymer HPMC and Ethyl cellulose in various concentrations. Compatibility studies indicate that there is no interaction between the excipient and the drug. All tablets formulations were subjected to

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Parmar, Ramesh D., Rajesh K. Parikh, G. Vidyasagar, Dhaval V. Patel, Chirag J. Patel, and Biraju D. Patel. "Pulsatile Drug Delivery Systems: An Overview." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 605–14. http://dx.doi.org/10.37285/ijpsn.2009.2.3.3.

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Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, single- an

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Bhaskar, Shrestha Sajan Maharjan* Himal Chhetry Panna Thapa. "Formulation and in vitro evaluation of floating pulsatile drug delivery system of Atenolol based on coated effervescent core." Int. J. in Pharm. Sci. 1, no. 8 (2023): 140–51. https://doi.org/10.5281/zenodo.8249869.

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Present research work attempts to design, formulate and optimize the floating pulsatile drug delivery system (FPPDS) intended to treat nocturnal hypertension. FPPDS was designed based on central reservoir system containing effervescent agent with rupturable coating and a buoyant layer on top of the coated core. This system consists of rapid release core that contains drug with disintegrants, osmogent (sodium chloride) and effervescent agent (sodium bicarbonate and tartaric acid) which was film coated by hydrophobic polymer Ethyl Cellulose(EC) with polyethylene Glycol(PEG) 6000 as a plasticizer

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Jagdale, Swati C., Nilesh A. Bari, Bhanudas S. Kuchekar, and Aniruddha R. Chabukswar. "Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/801769.

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The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of bisoprolol. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with gas generating agent. The rapid release core tablet (RRCT) was prepared by using superdisintegrants with active ingredient. Press coating of optimized RRCT was done by polymer. A 32full factorial design w

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Ramaswamy, Suresh, Stephanie B. Seminara, Barkat Ali, Philippe Ciofi, Nisar A. Amin, and Tony M. Plant. "Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus." Endocrinology 151, no. 9 (2010): 4494–503. http://dx.doi.org/10.1210/en.2010-0223.

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Human genetics indicate that kisspeptin and neurokinin B (NKB) signaling are necessary for generating pulsatile LH release and therefore for initiation of puberty and maintaining gonadal function. In the present study, male monkeys were employed to examine 1) whether activation of the NKB receptor (NK3R) is associated with GnRH release, and 2) hypothalamic localization of these peptides using immunofluorescence histochemistry. Agonadal juveniles, in which pituitary responsiveness to GnRH was heightened by GnRH priming, were employed to indirectly examine GnRH-releasing actions of NK3R and kiss

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Gore, Andrea C., Bret M. Windsor-Engnell, and Ei Terasawa. "Menopausal Increases in Pulsatile Gonadotropin-Releasing Hormone Release in a Nonhuman Primate (Macaca mulatta)." Endocrinology 145, no. 10 (2004): 4653–59. http://dx.doi.org/10.1210/en.2004-0379.

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Abstract Reproductive function in all vertebrates is controlled by the circhoral release of the neuropeptide, GnRH, into the portal capillary system leading to the anterior pituitary. Despite its primary role in sexual maturation and the maintenance of adult reproductive function, changes in the concentrations and pattern of GnRH release have not yet been reported in any primate species during the menopausal transition and postmenopause. Such knowledge is essential for ascertaining both the mechanisms for, and consequences of, the menopausal process. Here we used a push-pull perfusion method t

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Chirigati, Fernando. "Bringing the pulsatile release system to light." Nature Computational Science 2, no. 8 (2022): 467. http://dx.doi.org/10.1038/s43588-022-00307-z.

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MOTOBU, MASAKI, JUNICHI SASAKI, YUICHI NABESHIMA, NOBORU MESAKI, KATSUMI ASANO, and MASASUKE EDA. "PULSATILE RELEASE OF PLORACTIN IN ATHLETIC WOMEN." Japanese Journal of Physical Fitness and Sports Medicine 41, no. 2 (1992): 241–45. http://dx.doi.org/10.7600/jspfsm1949.41.241.

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Marchini, G., and S. Stock. "Pulsatile release of oxytocin in newborn infants." Reproduction, Fertility and Development 8, no. 1 (1996): 163. http://dx.doi.org/10.1071/rd9960163.

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Recently, a pulsatile, basal oxytocin blood level has been described in human adults. To investigate if such a hormone profile exists already during the neonatal period, we collected blood samples continuously with 20-s fractions for 4 min in 1-day-old infants (n = 26). Plasma oxytocin concentrations were determined by a specific radioimmunoassay. The values were further analysed by the pulse detection program PULSAR. We found that 42% of the infants presented one peak in the oxytocin level during a 4-min period. The peak constituted a 111 +/- 66% (mean +/- SD) increment of the baseline value.

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